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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RHOJ Gene

protein-coding GIFtS: 55
GCID: GC14P063671

ras homolog family member J

(Previous names: RAS-like, family 7, member B, ras homolog gene family,...)
(Previous symbols: RASL7B, ARHJ)

Explore 1 disease affiliated with
RHOJ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ras Homolog Family Member J¹ ²		Tc10-Like GTP-Binding Protein² ³
ARHJ¹ ² ³ ⁵		FLJ14445¹
TCL¹ ² ³ ⁵		TC10B²
RASL7B¹ ² ³		Rho-Related GTP-Binding Protein RhoJ²
Ras Homolog Gene Family, Member J¹ ²		TC10-Like Rho GTPase²
RAS-Like, Family 7, Member B¹ ²		RHOI³
Ras-Like Protein Family Member 7B² ³

External Ids:	HGNC: 688¹	Entrez Gene: 57381²	Ensembl: ENSG00000126785⁷	OMIM: 607653⁵	UniProtKB: Q9H4E5³

Export aliases for RHOJ gene to outside databases

Previous GC identifers: GC14P061662 GC14P062740 GC14P043837

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOJ:

This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal

adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial

growth factor and may regulate angiogenesis. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: RHOJ_HUMAN, Q9H4E5

Function: GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and

is involved in the regulation of cell morphology (By similarity)

Gene Wiki entry for RHOJ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHOJ gene promoter:
POU6F1 (c2) PPAR-gamma1 POU2F1 POU2F1b POU2F1a STAT3 PPAR-gamma2 POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHOJ promoter sequence

Search SABiosciences Chromatin IP Primers for RHOJ

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOJ

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2 Ensembl cytogenetic band: 14q23.2 HGNC cytogenetic band: 14q23.1

RHOJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOJ gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P063671: view genomic region (about GC identifiers)

Start:	63,670,832 bp from pter	End:	63,759,937 bp from pter
Size:	89,106 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHOJ_HUMAN, Q9H4E5 (See protein sequence)

Recommended Name: Rho-related GTP-binding protein RhoJ precursor

Size: 214 amino acids; 23821 Da

Subunit: Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp (By similarity)

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

Sequence caution: Sequence=BAB55013.1; Type=Frameshift; Positions=143;

Secondary accessions: Q96KC1

Alternative splicing: 2 isoforms: Q9H4E5-1 Q9H4E5-2 (No experimental confirmation available. Could be created by usage of an unusual splicing donor site)

Explore the universe of human proteins at neXtProt for RHOJ: NX_Q9H4E5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H4E5

RHOJ Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065714.1

ENSEMBL proteins:

ENSP00000451796 ENSP00000316729 ENSP00000451643

Reactome Protein details: Q9H4E5
Human Recombinant Protein Products for RHOJ:

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	Uscn Proteins for RHOJ

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--

RHOJ for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RHOJ

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RHOJ for domains About GeneDecksing

3 InterPro domains/families:

IPR003578 Small_GTPase_Rho

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

Graphical View of Domain Structure for InterPro Entry Q9H4E5

ProtoNet protein and cluster: Q9H4E5

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RHOJ_HUMAN, Q9H4E5

Similarity: Belongs to the small GTPase superfamily. Rho family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RHOJ_HUMAN, Q9H4E5

Function: GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and

is involved in the regulation of cell morphology (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	NAS	10967094
GO:0005515	protein binding	--	--
GO:0005525	GTP binding	IEA	--

RHOJ for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RHOJ:

Increased peripheral focal adh

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rhoj):

cardiovascular system

vision/eye

RHOJ for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RHOJ

miRNA Products:		OriGene 3'-UTR Clone: RHOJ Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOJ
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOJ:
		hsa-miR-182 hsa-miR-9 hsa-miR-4257
		SwitchGear 3'UTR luciferase reporter plasmid: RHOJ 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOJ

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Insulin Signaling

Insulin Signaling

1.00

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for RHOJ

Insulin Signaling

3 Reactome Pathways for RHOJ

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

RHOJ for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RHOJ

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/15 Interacting proteins for RHOJ (Q9H4E5³ ENSP00000316729⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACVR1	Q04771³, ENSP00000263640⁴	I2D: score=3 STRING: ENSP00000263640
PAK1	Q13153³, ENSP00000278568⁴	I2D: score=3 STRING: ENSP00000278568
SMAD2	Q15796³, ENSP00000262160⁴	I2D: score=3 STRING: ENSP00000262160
WAS	P42768³, ENSP00000365891⁴	I2D: score=2 STRING: ENSP00000365891
CDC42	P60953³, ENSP00000314458⁴	I2D: score=1 STRING: ENSP00000314458

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	NAS	10967094
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007266	Rho protein signal transduction	IEA	--
GO:0008360	regulation of cell shape	IEA	--
GO:0030036	actin cytoskeleton organization	IMP	10967094

RHOJ for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RHOJ

1 HMDB Compound for RHOJ About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about RHOJ

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RHOJ gene:

NM_020663.4

Unigene Cluster for RHOJ:

Ras homolog family member J

Hs.656339 [show with all ESTs]

Unigene Representative Sequence: NM_020663

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000557447 ENST00000316754(uc001xgb.2) ENST00000557133 ENST00000555125

miRNA Products:		OriGene 3'-UTR Clone: RHOJ Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOJ
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOJ:
		hsa-miR-182 hsa-miR-9 hsa-miR-4257
		SwitchGear 3'UTR luciferase reporter plasmid: RHOJ 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB209218.1 AF087862.1 AF309563.1 AF498977.1 AJ276567.1 AK027278.1 AK027351.1 AK096948.1

BC025770.1 BC062575.1

10 DOTS entries:

DT.97839937 DT.95369845 DT.120772794 DT.97839936 DT.97833617 DT.91731831 DT.120772761 DT.100740244

DT.444282 DT.95369843

24/107 AceView cDNA sequences (see all 107):

AA424648 BX953040 N27528 AJ276567 AF309563 BM932130 AI167357 BM685133

AI081149 AI066690 AI583530 BI764851 BM708726 BU663360 BX504485 AW022318

AA249338 AI379302 AK096948 BC062575 AA020825 AI366101 BF980166 AA461242

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHOJ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTGCCACG

About this image

RHOJ expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16)

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

Human umbilical vein endothelial cells (HUVEC) (Primary Cell)

Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RHOJ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHOJ

SOURCE GeneReport for Unigene cluster: Hs.656339

SABiosciences Custom PCR Arrays for RHOJ

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOJ Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOJ

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOJ gene from 7/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RHOJ¹	ras homolog gene family, member J	81.93(n) 88.32(a)		423513 XM_421413.3 XP_421413.1
lizard (Anolis carolinensis)	Reptilia	RHOJ⁶	--	89(a)	1 ↔ 1	1(2359895-2365779)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.13316²	Transcribed sequence with moderate similarity to protein more	80.57(n)		BX727320.1
zebrafish (Danio rerio)	Actinopterygii	rhoj¹	ras homolog gene family, member J	74.66(n) 87.24(a)		556371 NM_001044801.2 NP_001038266.1
honey bee (Apis mellifera)	Insecta	--	--	44(a)	possible ortholog	GroupUn.2917(49-952)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATROP6⁶ ROP1⁶ (see all 11)	Rac-like GTP-binding protein ARAC11 (see all 11)	52(a) 52(a) (see all 11)	many ↔ many many ↔ many (see all 11)	4(16672192-16674771) 3(19042887-19044372)
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	ras-related protein, putative, expressed (see all 9)	50(a) 50(a) (see all 9)	many ↔ many many ↔ many (see all 9)	2(1080513-1084283) 2(35874978-35879805)

ENSEMBL Gene Tree for RHOJ (if available)
TreeFam Gene Tree for RHOJ (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RHOJ gene

RHOH² RHOQ² RHOBTB1² RHOV² RHOG² RHOU² RHOBTB2² RAC1²

RAC2² CDC42² RAC3²

18/43 SIMAP similar genes for RHOJ using alignment to 3 protein entries: RHOJ_HUMAN (see all proteins) (see all similar genes):

RHOQ CDC42 RAC2 RAC1 RHOF RAC3

ARHG RHOG RHOH RHOC RHOU RHOD

RHOB RHOA ARHH RHOV ARHE RND3

RHOJ for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72712545^1,2	C	--	63669147(+)	`CCACAT/GTCACT`	1	--	us2k¹		4		NA WA EA	360
rs186280865^1,2		--	63669185(+)	`AAGAAA/CCTTCT`	1	--	us2k¹		0	--	--	--	--
rs143245093^1,2		--	63669203(+)	`CTGCCA/TAATAC`	1	--	us2k¹		0	--	--	--	--
rs144725938^1,2		--	63669211(+)	`TACATA/GTCATC`	1	--	us2k¹		0	--	--	--	--
rs17100844^1,2	C,F,H	--	63669262(+)	`GGATGA/TAGTCT`	1	--	us2k¹		27		NA NS EA CSA WA	2913
rs79584941^1,2		--	63669316(+)	`TGCCAC/ACTTCA`	1	--	us2k¹		1		NA	120
rs1957781^1,2	C,F,H	--	63669426(-)	`GATTTA/GTATAA`	1	--	us2k¹		12		NS EA NA WA	1166
rs1957780^1,2	C,F,O,H	--	63669442(-)	`ACCTAC/TGACTT`	1	--	us2k¹		22		NS EA NA WA CSA	1712
rs118019789^1,2		--	63669468(+)	`AGAATG/AGCACT`	1	--	us2k¹		1		NA	120
rs55806265^1,2	C	--	63669587(+)	`GGTAGG/AATTAT`	1	--	us2k¹		2		NA	122

HapMap Linkage Disequilibrium report for RHOJ (63670832 - 63759937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RHOJ
1 CNV: 8771
2 Indels: 60153 66651

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHOJ

DNA2.0 Custom Variant and Variant Library Synthesis for RHOJ

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RHOJ for disorders           About GeneDecksing

OMIM gene information: 607653    OMIM disorders: --

1 disease for RHOJ:    About MalaCards

carpal tunnel syndrome

Human Genome Epidemiology (HuGE) Navigator: RHOJ (1 document)

Export disorders for RHOJ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RHOJ gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RHOJ)

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world of online information

Characterization of TCL, a new GTPase of the Rho family related to TC10 and Cdc42. (PubMed id 10967094)^{1, 2, 3, 9} Vignal E.... Fort P. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage. (PubMed id 22971344)¹ Ho H....Ganesan A.K. (2012)
The role of RhoJ in endothelial cell biology and angi ogenesis. (PubMed id 22103495)¹ Leszczynska K....Heath V.L. (2011)
RhoJ/TCL regulates endothelial motility and tube form ation and modulates actomyosin contractility and focal adhesion numbers. (PubMed id 21148427)¹ Kaur S....Heath V.L. (2011)
RhoJ is an endothelial cell-restricted Rho GTPase tha t mediates vascular morphogenesis and is regulated by the transcription factor ERG. (PubMed id 21628409)¹ Yuan L....Oettgen P. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)¹ Barrios-Rodiles M....Wrana J.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57381	HGNC: 688	AceView: RHOJ	Ensembl:ENSG00000126785	euGenes: HUgn57381
ECgene: RHOJ	H-InvDB: RHOJ

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RHOJ	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RHOJ	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RHOJ gene
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Patent Information for RHOJ gene:
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ras homolog family member J

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ras homolog family member J

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