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Aliases for RHOJ Gene

Aliases for RHOJ Gene

  • Ras Homolog Family Member J 2 3
  • ARHJ 3 4 6
  • TCL 3 4 6
  • Ras Homolog Gene Family, Member J 2 3
  • Ras-Like Protein Family Member 7B 3 4
  • Tc10-Like GTP-Binding Protein 3 4
  • RAS-Like, Family 7, Member B 2 3
  • RASL7B 3 4
  • Rho-Related GTP-Binding Protein RhoJ 3
  • TC10-Like Rho GTPase 3
  • TC10B 3
  • RHOI 4

External Ids for RHOJ Gene

Previous HGNC Symbols for RHOJ Gene

  • RASL7B
  • ARHJ

Previous GeneCards Identifiers for RHOJ Gene

  • GC14P061662
  • GC14P062740
  • GC14P063671
  • GC14P043837

Summaries for RHOJ Gene

Entrez Gene Summary for RHOJ Gene

  • This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

GeneCards Summary for RHOJ Gene

RHOJ (Ras Homolog Family Member J) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOJ Gene

  • GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).

Gene Wiki entry for RHOJ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOJ Gene

Genomics for RHOJ Gene

Regulatory Elements for RHOJ Gene

Genomic Location for RHOJ Gene

63,204,114 bp from pter
63,293,512 bp from pter
89,399 bases
Plus strand

Genomic View for RHOJ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOJ Gene

Proteins for RHOJ Gene

  • Protein details for RHOJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related GTP-binding protein RhoJ
    Protein Accession:
    Secondary Accessions:
    • Q96KC1

    Protein attributes for RHOJ Gene

    214 amino acids
    Molecular mass:
    23821 Da
    Quaternary structure:
    • Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp.
    • Sequence=BAB55013.1; Type=Frameshift; Positions=143; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOJ Gene


neXtProt entry for RHOJ Gene

Proteomics data for RHOJ Gene at MOPED

Post-translational modifications for RHOJ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOJ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOJ Gene

Domains for RHOJ Gene

Suggested Antigen Peptide Sequences for RHOJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H4E5
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOJ: view

No data available for Gene Families for RHOJ Gene

Function for RHOJ Gene

Molecular function for RHOJ Gene

UniProtKB/Swiss-Prot Function: GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).

Gene Ontology (GO) - Molecular Function for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10967094
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOJ: view

Phenotypes for RHOJ Gene

MGI mutant phenotypes for RHOJ:
inferred from 1 alleles
GenomeRNAi human phenotypes for RHOJ:
genes like me logo Genes that share phenotypes with RHOJ: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RHOJ Gene

Localization for RHOJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOJ Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RHOJ Gene COMPARTMENTS Subcellular localization image for RHOJ gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 3
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with RHOJ: view

Pathways for RHOJ Gene

genes like me logo Genes that share pathways with RHOJ: view

Gene Ontology (GO) - Biological Process for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction IEA --
GO:0008152 metabolic process NAS 10967094
genes like me logo Genes that share ontologies with RHOJ: view

Compounds for RHOJ Gene

(1) HMDB Compounds for RHOJ Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RHOJ: view

Transcripts for RHOJ Gene

Unigene Clusters for RHOJ Gene

Ras homolog family member J:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOJ Gene

No ASD Table

Relevant External Links for RHOJ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOJ Gene

mRNA expression in normal human tissues for RHOJ Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RHOJ Gene

SOURCE GeneReport for Unigene cluster for RHOJ Gene Hs.656339

genes like me logo Genes that share expressions with RHOJ: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RHOJ Gene

Orthologs for RHOJ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOJ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOJ 35
  • 99.84 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia RHOJ 35
  • 92.83 (n)
  • 95.79 (a)
  • 96 (a)
(Canis familiaris)
Mammalia RHOJ 35
  • 93.15 (n)
  • 95.79 (a)
  • 96 (a)
(Mus musculus)
Mammalia Rhoj 35
  • 87.85 (n)
  • 92.99 (a)
Rhoj 16
Rhoj 36
  • 93 (a)
(Monodelphis domestica)
Mammalia RHOJ 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
-- 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Rhoj 35
  • 88.31 (n)
  • 95.26 (a)
(Gallus gallus)
Aves RHOJ 35
  • 82.94 (n)
  • 90.14 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia RHOJ 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoj 35
  • 76.95 (n)
  • 81.31 (a)
Str.13316 35
(Danio rerio)
Actinopterygii rhoj 35
  • 74.66 (n)
  • 87.24 (a)
rhoj 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoL 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC42 36
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10939 36
  • 52 (a)
CSA.6319 36
  • 50 (a)
Species with no ortholog for RHOJ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOJ Gene

Gene Tree for RHOJ (if available)
Gene Tree for RHOJ (if available)

Paralogs for RHOJ Gene

Paralogs for RHOJ Gene

genes like me logo Genes that share paralogs with RHOJ: view

Variants for RHOJ Gene

Sequence variations from dbSNP and Humsavar for RHOJ Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs15605 -- 63,293,116(-) GATTT(C/T)CATTT utr-variant-3-prime
rs718362 -- 63,275,867(+) AAAAA(C/T)ATTAA intron-variant
rs718363 -- 63,275,950(+) ACCCC(C/T)TTACC intron-variant
rs737571 -- 63,276,846(+) TAACA(A/T)CAGTT intron-variant
rs742904 -- 63,276,815(+) AAATC(A/T)GACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOJ Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV Gain 19592680
nsv902017 CNV Loss 21882294
esv2658318 CNV Deletion 23128226
esv2748771 CNV Deletion 23290073
dgv398e199 CNV Deletion 23128226
nsv826963 CNV Loss 20364138
esv28040 CNV Loss 19812545
nsv516899 CNV Loss 19592680
nsv521404 CNV Loss 19592680
nsv832815 CNV Gain 17160897
dgv87e55 CNV Gain 17911159
esv6302 CNV Gain 19470904

Relevant External Links for RHOJ Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOJ Gene

Disorders for RHOJ Gene

Relevant External Links for RHOJ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RHOJ: view

No data available for UniProtKB/Swiss-Prot for RHOJ Gene

Publications for RHOJ Gene

  1. Characterization of TCL, a new GTPase of the Rho family related to TC10 and Cdc42. (PMID: 10967094) Vignal E. … Fort P. (J. Biol. Chem. 2000) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers. (PMID: 21148427) Kaur S. … Heath V.L. (Arterioscler. Thromb. Vasc. Biol. 2011) 3

Products for RHOJ Gene

Sources for RHOJ Gene

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