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Aliases for RHOJ Gene

Aliases for RHOJ Gene

  • Ras Homolog Family Member J 2 3 5
  • Ras Homolog Gene Family, Member J 2 3
  • Ras-Like Protein Family Member 7B 3 4
  • Tc10-Like GTP-Binding Protein 3 4
  • RAS-Like, Family 7, Member B 2 3
  • RASL7B 3 4
  • ARHJ 3 4
  • TCL 3 4
  • Rho-Related GTP-Binding Protein RhoJ 3
  • TC10-Like Rho GTPase 3
  • TC10B 3
  • RHOI 4

External Ids for RHOJ Gene

Previous HGNC Symbols for RHOJ Gene

  • RASL7B
  • ARHJ

Previous GeneCards Identifiers for RHOJ Gene

  • GC14P061662
  • GC14P062740
  • GC14P063671
  • GC14P043837

Summaries for RHOJ Gene

Entrez Gene Summary for RHOJ Gene

  • This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

GeneCards Summary for RHOJ Gene

RHOJ (Ras Homolog Family Member J) is a Protein Coding gene. Diseases associated with RHOJ include Parasitic Ichthyosporea Infectious Disease and Rhinosporidiosis. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and ERK Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOQ.

UniProtKB/Swiss-Prot for RHOJ Gene

  • GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).

Gene Wiki entry for RHOJ Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOJ Gene

Genomics for RHOJ Gene

Regulatory Elements for RHOJ Gene

Enhancers for RHOJ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G063203 1.5 FANTOM5 ENCODE dbSUPER 23.2 +1.0 958 4.0 FOXA2 ARID4B YY1 GATA2 FOS ZHX2 MIER2 TBX21 ZNF491 ZNF518A RHOJ KCNH5 GPHB5 GC14M063214
GH14G063181 0.7 dbSUPER 22.9 -21.1 -21066 2.2 PKNOX1 MTA2 JUN DPF2 TBX21 FOXK2 GATA2 IKZF1 ZBTB33 RELB RHOJ LOC105370530
GH14G063174 1.6 Ensembl ENCODE dbSUPER 9.5 -29.1 -29090 1.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 FEZF1 ZNF2 RHOJ LOC105370530 PARP1P2
GH14G063214 0.7 ENCODE dbSUPER 14.1 +10.4 10384 0.9 JUN FOS RHOJ GC14M063214
GH14G063178 0.8 ENCODE dbSUPER 11.8 -24.7 -24718 2.2 GATA3 GATA2 JUN FOS RHOJ LOC105370530
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOJ on UCSC Golden Path with GeneCards custom track

Promoters for RHOJ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069495 1086 2400 ELF3 FOXA2 ARID4B BMI1 RAD21 YY1 GATA2 FOS ZHX2 MIER2

Genomic Location for RHOJ Gene

Chromosome:
14
Start:
63,204,114 bp from pter
End:
63,293,512 bp from pter
Size:
89,399 bases
Orientation:
Plus strand

Genomic View for RHOJ Gene

Genes around RHOJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOJ Gene

Proteins for RHOJ Gene

  • Protein details for RHOJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4E5-RHOJ_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoJ
    Protein Accession:
    Q9H4E5
    Secondary Accessions:
    • Q96KC1

    Protein attributes for RHOJ Gene

    Size:
    214 amino acids
    Molecular mass:
    23821 Da
    Quaternary structure:
    • Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp.
    SequenceCaution:
    • Sequence=BAB55013.1; Type=Frameshift; Positions=143; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOJ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOJ Gene

Post-translational modifications for RHOJ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOJ Gene

No data available for DME Specific Peptides for RHOJ Gene

Domains & Families for RHOJ Gene

Gene Families for RHOJ Gene

Suggested Antigen Peptide Sequences for RHOJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4E5

UniProtKB/Swiss-Prot:

RHOJ_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOJ: view

Function for RHOJ Gene

Molecular function for RHOJ Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).

Gene Ontology (GO) - Molecular Function for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10967094
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOJ: view
genes like me logo Genes that share phenotypes with RHOJ: view

Animal Models for RHOJ Gene

MGI Knock Outs for RHOJ:

Animal Model Products

miRNA for RHOJ Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOJ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOJ Gene

Localization for RHOJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOJ Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOJ gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 1
peroxisome 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with RHOJ: view

Pathways & Interactions for RHOJ Gene

genes like me logo Genes that share pathways with RHOJ: view

Gene Ontology (GO) - Biological Process for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IEA --
GO:0008360 regulation of cell shape IEA --
GO:0030036 actin cytoskeleton organization IMP 10967094
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOJ: view

No data available for SIGNOR curated interactions for RHOJ Gene

Drugs & Compounds for RHOJ Gene

(1) Drugs for RHOJ Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHOJ: view

Transcripts for RHOJ Gene

Unigene Clusters for RHOJ Gene

Ras homolog family member J:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOJ

Alternative Splicing Database (ASD) splice patterns (SP) for RHOJ Gene

No ASD Table

Relevant External Links for RHOJ Gene

GeneLoc Exon Structure for
RHOJ
ECgene alternative splicing isoforms for
RHOJ

Expression for RHOJ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOJ Gene

Protein differential expression in normal tissues from HIPED for RHOJ Gene

This gene is overexpressed in Breast (61.6) and Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RHOJ Gene



Protein tissue co-expression partners for RHOJ Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOJ Gene:

RHOJ

SOURCE GeneReport for Unigene cluster for RHOJ Gene:

Hs.656339

Evidence on tissue expression from TISSUES for RHOJ Gene

  • Intestine(4.2)
  • Nervous system(3.3)
  • Blood(2.3)
  • Kidney(2.2)
  • Eye(2)
  • Heart(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with RHOJ: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOJ Gene

Orthologs for RHOJ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOJ 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia RHOJ 34 35
  • 93.15 (n)
cow
(Bos Taurus)
Mammalia RHOJ 34 35
  • 92.83 (n)
oppossum
(Monodelphis domestica)
Mammalia RHOJ 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rhoj 34
  • 88.31 (n)
mouse
(Mus musculus)
Mammalia Rhoj 34 16 35
  • 87.85 (n)
chicken
(Gallus gallus)
Aves RHOJ 34 35
  • 82.94 (n)
lizard
(Anolis carolinensis)
Reptilia RHOJ 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoj 34
  • 76.95 (n)
Str.13316 34
zebrafish
(Danio rerio)
Actinopterygii rhoj 34 35
  • 74.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoL 35
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC42 35
  • 60 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10939 35
  • 52 (a)
ManyToMany
CSA.6319 35
  • 50 (a)
ManyToMany
Species where no ortholog for RHOJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOJ Gene

ENSEMBL:
Gene Tree for RHOJ (if available)
TreeFam:
Gene Tree for RHOJ (if available)

Paralogs for RHOJ Gene

Paralogs for RHOJ Gene

genes like me logo Genes that share paralogs with RHOJ: view

Variants for RHOJ Gene

Sequence variations from dbSNP and Humsavar for RHOJ Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000060517 -- 63,279,663(+) ATATT(C/T)TGCTC intron-variant
rs1000060772 -- 63,225,068(+) TGCCT(C/G)AGCCT intron-variant
rs1000107560 -- 63,254,078(+) TCCCC(C/G)AGGAC intron-variant
rs1000114346 -- 63,210,439(+) AGTAA(A/C)CCTAA intron-variant
rs1000130187 -- 63,275,881(+) ACCAG(C/T)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOJ Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV gain 19592680
dgv398e199 CNV deletion 23128226
dgv87e55 CNV gain 17911159
esv2658318 CNV deletion 23128226
esv2748771 CNV deletion 23290073
esv28040 CNV loss 19812545
esv3551642 CNV deletion 23714750
esv3567910 CNV gain 25503493
esv3634722 CNV loss 21293372
esv6302 CNV gain 19470904
nsv1051684 CNV gain 25217958
nsv1153869 CNV deletion 26484159
nsv516899 CNV loss 19592680
nsv521404 CNV loss 19592680
nsv564893 CNV gain 21841781
nsv564894 CNV loss 21841781
nsv564895 CNV loss 21841781
nsv564896 CNV loss 21841781
nsv826963 CNV loss 20364138
nsv832815 CNV gain 17160897
nsv952850 CNV deletion 24416366
nsv957488 CNV deletion 24416366

Variation tolerance for RHOJ Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOJ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOJ Gene

Disorders for RHOJ Gene

MalaCards: The human disease database

(5) MalaCards diseases for RHOJ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
parasitic ichthyosporea infectious disease
rhinosporidiosis
  • infection by rhinosporidium seeberi
suppurative thyroiditis
  • acute suppurative thyroiditis
pediatric lymphoma
  • childhood lymphoma
lung lymphoma
  • lymphoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search RHOJ in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHOJ

Genetic Association Database (GAD)
RHOJ
Human Genome Epidemiology (HuGE) Navigator
RHOJ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOJ
genes like me logo Genes that share disorders with RHOJ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOJ Gene

Publications for RHOJ Gene

  1. Characterization of TCL, a new GTPase of the Rho family related to TC10 and Cdc42. (PMID: 10967094) Vignal E. … Fort P. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RHOJ Gene

  • Addgene plasmids for RHOJ

Sources for RHOJ Gene

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