Aliases for RHOJ Gene
External Ids for RHOJ Gene
Previous HGNC Symbols for RHOJ Gene
Previous GeneCards Identifiers for RHOJ Gene
This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
GeneCards Summary for RHOJ Gene
RHOJ (Ras Homolog Family Member J) is a Protein Coding gene. Diseases associated with RHOJ include Parasitic Ichthyosporea Infectious Disease and Rhinosporidiosis. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.
UniProtKB/Swiss-Prot for RHOJ Gene
GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).