Aliases for RHOJ Gene
External Ids for RHOJ Gene
Previous HGNC Symbols for RHOJ Gene
Previous GeneCards Identifiers for RHOJ Gene
This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
GeneCards Summary for RHOJ Gene
RHOJ (Ras Homolog Family Member J) is a Protein Coding gene. Diseases associated with RHOJ include parasitic ichthyosporea infectious disease and rhinosporidiosis. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.
UniProtKB/Swiss-Prot for RHOJ Gene
GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).