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RHOJ Gene

protein-coding   GIFtS: 55
GCID: GC14P063671

Ras Homolog Family Member J

(Previous names: RAS-like, family 7, member B, ras homolog gene family, member...)
(Previous symbols: RASL7B, ARHJ)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member J1 2     Ras-Like Protein Family Member 7B2 3
ARHJ1 2 3 5     Tc10-Like GTP-Binding Protein2 3
RASL7B1 2 3     TC10B2
TCL2 3 5     Rho-Related GTP-Binding Protein RhoJ2
Ras Homolog Gene Family, Member J1 2     TC10-Like Rho GTPase2
RAS-Like, Family 7, Member B1 2     RHOI3

External Ids:    HGNC: 6881   Entrez Gene: 573812   Ensembl: ENSG000001267857   OMIM: 6076535   UniProtKB: Q9H4E53   

Export aliases for RHOJ gene to outside databases

Previous GC identifers: GC14P061662 GC14P062740 GC14P043837


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHOJ Gene:
This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal
adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular
endothelial growth factor and may regulate angiogenesis. (provided by RefSeq, Dec 2011)

GeneCards Summary for RHOJ Gene:
RHOJ (ras homolog family member J) is a protein-coding gene. Diseases associated with RHOJ include carpal tunnel syndrome, and endotheliitis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RHOJ_HUMAN, Q9H4E5
Function: GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in
fibroblasts and is involved in the regulation of cell morphology (By similarity)

Gene Wiki entry for RHOJ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOJ gene promoter:
         POU6F1 (c2)   PPAR-gamma1   POU2F1   POU2F1b   POU2F1a   STAT3   PPAR-gamma2   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOJ promoter sequence
   Search Chromatin IP Primers for RHOJ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOJ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2   Ensembl cytogenetic band:  14q23.2   HGNC cytogenetic band: 14q23.1

RHOJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOJ gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P063671:  view genomic region     (about GC identifiers)

Start:
63,670,832 bp from pter      End:
63,759,937 bp from pter
Size:
89,106 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHOJ_HUMAN, Q9H4E5 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoJ precursor  
Size: 214 amino acids; 23821 Da
Subunit: Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp (By similarity)
Sequence caution: Sequence=BAB55013.1; Type=Frameshift; Positions=143;
Secondary accessions: Q96KC1
Alternative splicing: 2 isoforms:  Q9H4E5-1   Q9H4E5-2   (No experimental confirmation available. Could be created by usage of an unusual splicing donor site)

Explore the universe of human proteins at neXtProt for RHOJ: NX_Q9H4E5

Explore proteomics data for RHOJ at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RHOJ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065714.1  
    ENSEMBL proteins: 
     ENSP00000451796   ENSP00000316729   ENSP00000451643  
    Reactome Protein details: Q9H4E5

    RHOJ Human Recombinant Protein Products:

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    Novus Biologicals RHOJ Protein
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    Cloud-Clone Corp. Proteins for RHOJ

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    Cloud-Clone Corp. CLIAs for RHOJ


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H4E5

    ProtoNet protein and cluster: Q9H4E5

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOJ_HUMAN, Q9H4E5
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOJ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOJ_HUMAN, Q9H4E5
    Function: GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in
    fibroblasts and is involved in the regulation of cell morphology (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10967094
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
         
    RHOJ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RHOJ:
     Increased peripheral focal adh 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhoj):
     cardiovascular system  vision/eye 

    RHOJ for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHOJ
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOJ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOJ

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate RHOJ:
    hsa-miR-182 hsa-miR-9 hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidRHOJ 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHOJ

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOJ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOJ_HUMAN, Q9H4E5: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    extracellular3
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    RHOJ for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOJ About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Insulin Signaling
    Insulin Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RHOJ (see all 6)
        Actin-Based Motility by Rho Family GTPases
    ILK Signaling
    Actin Nucleation and Branching
    Germ Cell-Sertoli Cell Junction Dynamics
    Tec Kinases Signaling

    1 BioSystems Pathway for RHOJ
        Insulin Signaling


    1 Reactome Pathway for RHOJ
        Rho GTPase cycle



    RHOJ for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHOJ
    Interactions:

        Search GeneGlobe Interaction Network for RHOJ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RHOJ (Q9H4E53 ENSP000003167294) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    PAK1Q131533, ENSP000002785684I2D: score=3 STRING: ENSP00000278568
    SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
    WASP427683, ENSP000003658914I2D: score=2 STRING: ENSP00000365891
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS10967094
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction IEA--
    GO:0008360regulation of cell shape IEA--

    RHOJ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOJ

    1 HMDB Compound for RHOJ    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RHOJ gene: 
    NM_020663.4  

    Unigene Cluster for RHOJ:

    Ras homolog family member J
    Hs.656339  [show with all ESTs]
    Unigene Representative Sequence: NM_020663
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557447 ENST00000316754(uc001xgb.2) ENST00000557133 ENST00000555125

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate RHOJ:
    hsa-miR-182 hsa-miR-9 hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidRHOJ 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RHOJ
    Predesigned siRNA for gene silencing in human, mouse, rat RHOJ
    Clone
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    OriGene ORF clones in mouse, rat for RHOJ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOJ (NM_020663)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOJ
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    Primer
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    OriGene qPCR primer pairs and template standards for RHOJ
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOJ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOJ
      QuantiTect SYBR Green Assays in human, mouse, rat RHOJ
      QuantiFast Probe-based Assays in human, mouse, rat RHOJ

    Additional mRNA sequence: 

    AB209218.1 AF087862.1 AF309563.1 AF498977.1 AJ276567.1 AK027278.1 AK027351.1 AK096948.1 
    BC025770.1 BC062575.1 

    10 DOTS entries:

    DT.97839937  DT.95369845  DT.120772794  DT.97839936  DT.97833617  DT.91731831  DT.120772761  DT.100740244 
    DT.444282  DT.95369843 

    Selected AceView cDNA sequences (see all 107):

    AI066690 BX953040 BM932130 AA424648 AI167357 BM708726 AJ276567 AI379302 
    BI764851 BX504485 BC062575 BU663360 BM685133 N27528 AF309563 AI081149 
    AW022318 AK096948 AA249338 AI583530 AA020825 AL600110 BU731919 AF087862 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOJ expression in normal human tissues (normalized intensities)      RHOJ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGCCACG
    RHOJ Expression
    About this image


    RHOJ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem E15, Meso-prx/latp Progenitor
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    RHOJ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOJ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656339
        Custom PCR Arrays for RHOJ
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOJ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOJ gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhoj1 , 5 ras homolog gene family, member J1, 5 87.85(n)1
    92.99(a)1
      12 (32.63 cM)5
    808371  NM_023275.21  NP_075764.11 
     753083225 
    chicken
    (Gallus gallus)
    Aves RHOJ1 ras homolog gene family, member J 82.94(n)
    90.14(a)
      423513  NM_001277548.1  NP_001264477.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOJ6
    ras homolog family member J
    88(a)
    1 ↔ 1
    1(2355840-2449913)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.133162 Transcribed sequence with moderate similarity to protein more 80.57(n)    BX727320.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rhoj1 ras homolog gene family, member J 74.66(n)
    87.24(a)
      556371  NM_001044801.2  NP_001038266.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoL6
    rho-like
    40(a)
    1 → many
    3R(5322823-5328299)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC426
    Small rho-like GTPase, essential for establishment...
    60(a)
    1 → many
    XII(604212-604787) YLR229C


    ENSEMBL Gene Tree for RHOJ (if available)
    TreeFam Gene Tree for RHOJ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOJ gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC12  
    RAC22  CDC422  RAC32  
    Selected SIMAP similar genes for RHOJ using alignment to 3 protein entries:     RHOJ_HUMAN (see all proteins) (see all similar genes):
    RHOQ    CDC42    RAC2    RAC1    RHOF    RAC3
    ARHG    RHOG    RHOH    RHOC    RHOU    RHOD
    RHOB    RHOA    ARHH    RHOV    ARHE    RND3

    RHOJ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOJ (see all 1766)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727125451,2
    C--63669147(+) CCACAT/GTCACT 1 -- us2k14Minor allele frequency- G:0.13NA WA EA 360
    rs1862808651,2
    --63669185(+) AAGAAA/CCTTCT 1 -- us2k10--------
    rs1432450931,2
    --63669203(+) CTGCCA/TAATAC 1 -- us2k10--------
    rs1447259381,2
    --63669211(+) TACATA/GTCATC 1 -- us2k10--------
    rs171008441,2
    C,F,H--63669262(+) GGATGA/TAGTCT 1 -- us2k127Minor allele frequency- T:0.14NA NS EA CSA WA 2913
    rs795849411,2
    F--63669316(+) TGCCAC/ACTTCA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs19577811,2
    C,F,H--63669426(-) GATTTA/GTATAA 1 -- us2k112Minor allele frequency- G:0.13NS EA NA WA 1166
    rs19577801,2
    C,F,O,H--63669442(-) ACCTAC/TGACTT 1 -- us2k122Minor allele frequency- T:0.05NS EA NA WA CSA 1712
    rs1180197891,2
    F--63669468(+) AGAATG/AGCACT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs558062651,2
    C,F--63669587(+) GGTAGG/AATTAT 1 -- us2k12Minor allele frequency- A:0.08NA 122

    HapMap Linkage Disequilibrium report for RHOJ (63670832 - 63759937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RHOJ (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv398e199CNV Deletion23128226
    esv2658318CNV Deletion23128226
    esv2748771CNV Deletion23290073
    nsv902017CNV Loss21882294
    nsv516899CNV Loss19592680
    nsv826963CNV Loss20364138
    esv28040CNV Loss19812545
    nsv521404CNV Loss19592680
    dgv87e55CNV Gain17911159
    dgv137n21CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607653    OMIM disorders: --

    5 diseases for RHOJ:    About MalaCards
    carpal tunnel syndrome    endotheliitis    melanoma    retinitis
    thyroiditis


    RHOJ for disorders           About GeneDecksing

    Genetic Association Database (GAD): RHOJ
    Human Genome Epidemiology (HuGE) Navigator: RHOJ (1 document)

    Export disorders for RHOJ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOJ gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with RHOJ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of TCL, a new GTPase of the Rho family related to TC10 and Cdc42. (PubMed id 10967094)1, 2, 3, 9 Vignal E.... Fort P. (J. Biol. Chem. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. (PubMed id 24434213)1 Kim C....Koh G.Y. (Cancer Cell 2014)
    6. RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics. (PubMed id 23253891)1 Ho H....Ganesan A.K. (amp 2013)
    7. Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. (PubMed id 23029280)1 Kusuhara S....Uemura A. (PLoS ONE 2012)
    8. RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage. (PubMed id 22971344)1 Ho H....Ganesan A.K. (Cancer Res. 2012)
    9. RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers. (PubMed id 21148427)1 Kaur S....Heath V.L. (Arterioscler. Thromb. Vasc. Biol. 2011)
    10. The role of RhoJ in endothelial cell biology and angiogenesis. (PubMed id 22103495)1 Leszczynska K....Heath V.L. (Biochem. Soc. Trans. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57381 HGNC: 688 AceView: RHOJ Ensembl:ENSG00000126785 euGenes: HUgn57381
    ECgene: RHOJ H-InvDB: RHOJ

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RHOJ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOJ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHOJ gene:
    Search GeneIP for patents involving RHOJ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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