RHOH Gene
protein-coding GIFtS: 59
GCID: GC04P040192
|
|
ras homolog family member H(Previous names: ras homolog gene family, member H )
(Previous symbol: ARHH)
| |
Aliases
for RHOH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ras Homolog Family Member H1 2 | | GTP-Binding Protein TTF2 3 | | ARHH1 2 3 5 | | RhoH1 | | TTF1 2 3 5 | | Rho-Related GTP-Binding Protein RhoH2 | | Ras Homolog Gene Family, Member H1 2 | | TTF, Translocation Three Four2 | | Translocation Three Four Protein2 3 | | |
Export aliases for RHOH gene to outside databasesPrevious GC identifers: GC04P040096 GC04P040021 GC04P039875 GC04P040198 GC04P039521 |
Summaries
for RHOH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RHOH:
The protein encoded by this gene is a member of the Ras superfamily of small GTPases. Expression of a chimerictranscript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas.This gene encodes a small G-like protein, and unlike most other small G proteins which are expressed ubiquitously,this gene is transcribed only in hemopoietic cells. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669Function: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulatorof thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70.Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediatedpathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependentphosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitatingphosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2,PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPaseactivity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF andIKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulatesleukotriene production in neutrophils
Gene Wiki entry for RHOH (RhoH)
|
Genomic Views
for RHOH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016297.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RHOH gene promoter:
LHX3b/Lhx3b p53 STAT5A NF-AT c-Ets-1 NF-AT4 NF-AT2 NF-AT3 LHX3a/Lhx3a NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RHOH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p13 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p13RHOH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P040192: view genomic region
(about GC identifiers)
Start:
|
40,192,673 bp from pter |
End:
|
40,246,281 bp from pter |
Size:
|
53,609 bases |
Orientation:
|
plus strand |
|
Proteins
for RHOH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669 (See
protein sequence)Recommended Name: Rho-related GTP-binding protein RhoH precursor Size: 191 amino acids; 21331 Da
Subunit: Interacts with ZAP70 (via SH2 domains) and the interaction is enhanced by its phosphorylation by LCK.Interacts with SYK and the interaction is enhanced by its phosphorylation by FYN (By similarity). Interacts with GDI1and GDI2. Interacts with PAK7/PAK5 (By similarity)
Subcellular location: Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Co-localizestogether with ZAP70 in the immunological synapse (By similarity)Explore the universe of human proteins at neXtProt for RHOH: NX_Q15669
Post-translational modifications:
Phosphorylated on tyrosine by LCK. Phosphorylated by FYN. Phosphorylation enhances the interactions with ZAP70 and SYKand is critical for its function in thymocyte development (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15669
RHOH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004301.1
ENSEMBL proteins: ENSP00000425010 ENSP00000423384 ENSP00000422241 ENSP00000426439 ENSP00000371219 ENSP00000420866 Reactome Protein details: Q15669
Human Recombinant Protein Products for RHOH:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RHOH for ontologies About GeneDecksing
RHOH Antibody Products:
Assay Products for RHOH: |
Protein
Domains /
Families
for RHOH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RHOH for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15669ProtoNet protein and cluster: Q15669 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669Domain: The region involved in interaction with ZAP70 is a non-canonical immunoreceptor tyrosine-based activation motif(ITAM) (By similarity)Similarity: Belongs to the small GTPase superfamily. Rho family |
Function
for RHOH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RHOH_HUMAN, Q15669Function: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulatorof thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70.Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediatedpathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependentphosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitatingphosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2,PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPaseactivity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF andIKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulatesleukotriene production in neutrophilsInduction: By CSF2/GM-CSF. Down-regulated by phorbol myristate acetate (PMA) Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
RHOH for ontologies About GeneDecksing
Phenotypes:
3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rhoh):
RHOH for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for RHOH: Rhohtm1Brak Rhohtm1Daw
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOH
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RHOH (NM_004310) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHOH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOH |
|
Pathways & Interactions
for RHOH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Leukocyte transendothelial migration | | | 3 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for RHOH
1 
Kegg Pathway (Kegg details for RHOH):
RHOH for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHOH
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/75 Interacting proteins for RHOH (Q156692, 3 ENSP000003712194) via UniProtKB, MINT, STRING, and/or I2D (see all 75)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
RHOH for ontologies About GeneDecksing
|
Drugs & Compounds
for RHOH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RHOH for compounds About GeneDecksing
 Browse Tocris compounds for RHOH
7 Novoseek chemical compound relationships for RHOH gene About this table
Search CenterWatch for drugs/clinical trials and news about RHOH
|
Transcripts
for RHOH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RHOH gene: NM_004310.3 Unigene Cluster for RHOH: Ras homolog family member H Hs.654594 [show with all ESTs]Unigene Representative Sequence: AK09711716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000505618 ENST00000507851 ENST00000503754 ENST00000508513 ENST00000511967
ENST00000503941 ENST00000381799(uc003guz.2) ENST00000514839 ENST00000513894
ENST00000515702 ENST00000515718 ENST00000515503 ENST00000514143 ENST00000504638
ENST00000511121 ENST00000503978
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOH
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RHOH (NM_004310) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHOH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOH |
Additional cDNA sequence: AF498975.1 AK097117.1 AK313744.1 AY673952.1 AY673953.1 AY673956.1 BC014261.2 CR450349.1 Z35227.1 15 DOTS entries: DT.310854 DT.121223917 DT.95163415 DT.121223953 DT.95073024 DT.75123900 DT.121223958 DT.100695373 DT.100857545 DT.121223909 DT.121223937 DT.121223970 DT.433771 DT.95163414 DT.99983020 24/104 AceView cDNA sequences (see all 104): AY673954 CR619539 CR450349 BX404688 CR607001 AY673956 BU626663 BP338424 BC014261 CD367666 AF498975 BX421813 AY673953 BP367186 CD367697 NM_004310 AY673955 BX447460 AL532319 AI818677 CD639044 AI371502 BE675971 BE042391
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RHOH (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | | | | | | |
| ExUns: | 10d | · | 10e | · | 10f | · | 10g |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for RHOH
|
Expression
for RHOH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RHOH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGGGAAGA
About this image
See RHOH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHOH
SOURCE GeneReport for Unigene cluster: Hs.654594
UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669Tissue specificity: Expressed only in hematopoietic cells. Present at very high levels in the thymus, less abundant inthe spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of T-helper cellsthan in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as cystic fibrosis,ulcerative colitis and appendicitis
SABiosciences Custom PCR Arrays for RHOH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOH |
Orthologs
for RHOH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RHOH gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RHOH1 |
ras homolog gene family, member H |
79.41(n)
84.29(a) |
|
428786 XM_426342.3 XP_426342.2 |
lizard
(Anolis carolinensis) |
Reptilia |
RHOH6 |
-- |
77(a) |
1 ↔ 1 |
5(99975702-99976277) |
zebrafish
(Danio rerio) |
Actinopterygii |
rhoh1 |
ras homolog gene family, member H |
67.91(n)
76.6(a) |
|
553413 XM_002660452.1 XP_002660498.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
crp-16 |
Cdc-42 Related Protein family member (crp-1) |
33(a) |
possible ortholog |
V(10478567-10480942) |
ENSEMBL Gene Tree for RHOH (if available)
TreeFam Gene Tree for RHOH (if available) |
Paralogs
for RHOH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RHOH gene
- RHOQ2 RHOBTB12 RHOV2 RHOG2 RHOU2 RHOBTB22 RAC12 RAC22
- CDC422 RHOJ2 RAC32
18/62 SIMAP similar genes for RHOH using alignment to 4 protein entries: RHOH_HUMAN (see all proteins)
(see all similar genes):ARHH RHOJ RHOQ RAC2 RHOF ARHG
RHOG CDC42 RHOA RHOC RAC3 RHOB
RHOD RHOV RAC1 RHOU RND2 ARHE
RHOH for paralogs About GeneDecksing
|
Genomic Variants
for RHOH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RHOH (40192673 - 40246281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RHOH
1 Inversion: 29431
Human Gene Mutation Database (HGMD): RHOH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHOH |
|
Disorders
/ Diseases
for RHOH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RHOH for disorders About GeneDecksing
OMIM gene information: 602037
OMIM disorders: --
UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
Note=A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocationt(3;4)(q27;p11) with BCL6
20/24  diseases for RHOH (see all 24): About MalaCardsnon-hodgkin lymphoma hodgkin's lymphoma marginal zone b-cell lymphoma diffuse large b-cell lymphoma
b-cell lymphomas clostridium difficile hairy cell leukemia chronic lymphocytic leukemia
lymphocytic leukemia ulcerative colitis appendicitis malignant glioma
cystic fibrosis multiple myeloma t-cell leukemia kidney disease
leukemia myeloma hematopoiesis fibrosis
1 Novoseek disease relationship for RHOH gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
9478968 (1) |
Human Genome Epidemiology (HuGE) Navigator: RHOH (1 document)
Export disorders for RHOH gene to outside databases
|
Publications
for RHOH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RHOH gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with RHOH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TTF, a gene encoding a novel small G protein, fuses to the lymphoma- associated LAZ3 gene by t(3;4) chromosomal translocation. (PubMed id 7784061)1, 2, 3, 9 Dallery E.... Kerckaert J.-P. (1995)
- RhoH/TTF negatively regulates leukotriene production in neutrophils. (PubMed id 19414807)1, 2 Daryadel A.... Simon H.-U. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. (PubMed id 11809807)1, 2 Li X.... Lim B. (2002)
- Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation. (PubMed id 15563831)1, 9 Lahousse S....Galiegue-Zouitina S. (2004)
- Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization. (PubMed id 9226377)1, 9 Dallery-Prudhomme E....Galiegue-Zouitina S. (1997)
- RhoH is critical for cell-microenvironment interaction s in chronic lymphocytic leukemia in mice and humans. (PubMed id 22474251)1 Troeger A....Williams D.A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Human RHOH deficiency causes T cell defects and suscep tibility to EV-HPV infections. (PubMed id 22850876)1 Crequer A....Jouanguy E. (2012)
- Opposing roles for RhoH GTPase during T-cell migration and activation. (PubMed id 22689994)1 Baker C.M....Kim M. (2012)
|
External Searches for RHOH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RHOH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing RHOH gene
(According to HUGE)
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Specialized Databases showing RHOH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RHOH gene:
Search GeneIP for patents involving RHOH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RHOH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RHOH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOH | | | OriGene Protein Over-expression Lysate for RHOH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RHOH | | OriGene 3'-UTR Clone for RHOH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RHOH | | OriGene Custom Protein Services for RHOH | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHOH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHOH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOH |
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| | | | Search Tocris compounds for RHOH |
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 | | | RHOH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOH |
|  |  |  |  | | | | ThermoFisher Antibody for RHOH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOH |
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