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RHOH Gene

protein-coding   GIFtS: 59
GCID: GC04P040192

Ras Homolog Family Member H

(Previous names: ras homolog gene family, member H)
(Previous symbol: ARHH)
  See RHOH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member H1 2     GTP-Binding Protein TTF2 3
ARHH1 2 3 5     Rho-Related GTP-Binding Protein RhoH2
TTF2 3 5     TTF, Translocation Three Four2
Ras Homolog Gene Family, Member H1 2     Translocation Three Four Protein3

External Ids:    HGNC: 6861   Entrez Gene: 3992   Ensembl: ENSG000001684217   OMIM: 6020375   UniProtKB: Q156693   

Export aliases for RHOH gene to outside databases

Previous GC identifers: GC04P040096 GC04P040021 GC04P039875 GC04P040198 GC04P039521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHOH Gene:
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing
enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of
cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal
translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome
3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in
multiple transcript variants that encode the same protein. (provided by RefSeq, May 2013)

GeneCards Summary for RHOH Gene:
RHOH (ras homolog family member H) is a protein-coding gene. Diseases associated with RHOH include nodal marginal zone b-cell lymphoma, and t-cell immunodeficiency with epidermodysplasia verruciformis. GO annotations related to this gene include GTP binding and GTPase inhibitor activity. An important paralog of this gene is RHOQ.

UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
Function: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical
regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and
activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent
activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by
promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial
for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast
cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for
the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity).
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities
of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils

Gene Wiki entry for RHOH (RhoH) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOH gene promoter:
         LHX3b/Lhx3b   p53   STAT5A   NF-AT   c-Ets-1   NF-AT4   NF-AT2   NF-AT3   LHX3a/Lhx3a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOH promoter sequence
   Search Chromatin IP Primers for RHOH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p13

RHOH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOH gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P040192:  view genomic region     (about GC identifiers)

Start:
40,192,673 bp from pter      End:
40,248,587 bp from pter
Size:
55,915 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoH precursor  
Size: 191 amino acids; 21331 Da
Subunit: Interacts with ZAP70 (via SH2 domains) and the interaction is enhanced by its phosphorylation by LCK.
Interacts with SYK and the interaction is enhanced by its phosphorylation by FYN (By similarity). Interacts with
GDI1 and GDI2. Interacts with PAK7/PAK5 (By similarity)

Explore the universe of human proteins at neXtProt for RHOH: NX_Q15669

Explore proteomics data for RHOH at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine by LCK. Phosphorylated by FYN. Phosphorylation enhances the interactions with ZAP70 and
    SYK and is critical for its function in thymocyte development (By similarity)1
  • Ubiquitination2 at Lys17, Lys138, Lys146

  • See RHOH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (12 alternative transcripts): 
    NP_001265288.1  NP_001265289.1  NP_001265290.1  NP_001265291.1  NP_001265292.1  NP_001265293.1  NP_001265294.1  NP_001265295.1  
    NP_001265296.1  NP_001265297.1  NP_001265298.1  NP_004301.1  

    ENSEMBL proteins: 
     ENSP00000425010   ENSP00000423384   ENSP00000422241   ENSP00000426439   ENSP00000371219  
     ENSP00000420866  
    Reactome Protein details: Q15669

    RHOH Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RHOH
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    Novus Biologicals RHOH Protein
    Novus Biologicals RHOH Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHOH

     
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    antibodies-online proteins for RHOH (2 products) 

     
    antibodies-online peptides for RHOH

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    antibodies-online antibodies for RHOH (33 products) 

    RHOH Assay Products:

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    Cloud-Clone Corp. ELISAs for RHOH
    Cloud-Clone Corp. CLIAs for RHOH
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    antibodies-online kits for RHOH (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q15669

    ProtoNet protein and cluster: Q15669

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
    Domain: The region involved in interaction with ZAP70 is a non-canonical immunoreceptor tyrosine-based activation
    motif (ITAM) (By similarity)
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RHOH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOH_HUMAN, Q15669
    Function: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical
    regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and
    activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent
    activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by
    promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial
    for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast
    cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for
    the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity).
    Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
    Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities
    of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils
    Induction: By CSF2/GM-CSF. Down-regulated by phorbol myristate acetate (PMA)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005095GTPase inhibitor activity NAS11809807
    GO:0005515protein binding IPI11809807
    GO:0005525GTP binding IDA11809807
    GO:0017048Rho GTPase binding NAS11809807
    GO:0019210kinase inhibitor activity IDA11809807
         
    Find genes that share ontologies with RHOH           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rhoh):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with RHOH           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RHOH: Rhohtm1Brak Rhohtm1Daw

       genOway: Develop your customized and physiologically relevant rodent model for RHOH

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRHOH 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHOH

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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for RHOH 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOH_HUMAN, Q15669: Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Colocalizes
    together with ZAP70 in the immunological synapse (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    mitochondrion4
    extracellular2
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11809807
    GO:0005739mitochondrion ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with RHOH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOH About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Leukocyte transendothelial migration
    Leukocyte transendothelial migration


    Find genes that share SuperPaths with RHOH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RHOH (see all 34)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Crosstalk Between CARM1 and ESRs

    1 Reactome Pathway for RHOH
        Rho GTPase cycle


    1 Kegg Pathway  (Kegg details for RHOH):
        Leukocyte transendothelial migration

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHOH
    Interactions:

        Search GeneGlobe Interaction Network for RHOH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOH (Q156692, 3 ENSP000003712194) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNH2Q128092, 3, ENSP000002621864MINT-64255 I2D: score=3 STRING: ENSP00000262186
    RHOAP615862, 3, ENSP000004001754MINT-56521 I2D: score=1 STRING: ENSP00000400175
    LRIF1Q5T3J32, 3MINT-64257 I2D: score=4 
    UTP14AQ9BVJ62, 3MINT-64256 I2D: score=4 
    ARHGDIGQ998193, ENSP000002194094I2D: score=2 STRING: ENSP00000219409
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006355regulation of transcription, DNA-templated NAS11809807
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport ----

    Find genes that share ontologies with RHOH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOH

    7 Novoseek inferred chemical compound relationships for RHOH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geranylgeranyl pyrophosphate 64.9 1 11390424 (1)
    gtp 54.3 10 9451818 (1), 14992721 (1), 10676816 (1), 9780206 (1) (see all 9)
    gdp 51.2 1 8798610 (1)
    toxin a 49 1 8944363 (1)
    mevalonate 47.2 1 11390424 (1)
    actomyosin 38.9 1 9478968 (1)
    tyrosine 19.2 1 10652228 (1)



    Find genes that share compounds with RHOH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHOH gene (12 alternative transcripts): 
    NM_001278359.1  NM_001278360.1  NM_001278361.1  NM_001278362.1  NM_001278363.1  NM_001278364.1  NM_001278365.1  NM_001278366.1  
    NM_001278367.1  NM_001278368.1  NM_001278369.1  NM_004310.4  

    Unigene Cluster for RHOH:

    Ras homolog family member H
    Hs.654594  [show with all ESTs]
    Unigene Representative Sequence: AK097117
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505618 ENST00000507851 ENST00000503754 ENST00000508513 ENST00000511967
    ENST00000503941 ENST00000381799(uc003guz.2) ENST00000514839 ENST00000513894
    ENST00000515702 ENST00000515718 ENST00000515503 ENST00000514143 ENST00000504638
    ENST00000511121 ENST00000503978
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      QuantiFast Probe-based Assays in human, mouse, rat RHOH

    Additional mRNA sequence: 

    AF498975.1 AK097117.1 AK313744.1 AY673952.1 AY673953.1 AY673956.1 BC014261.2 CR450349.1 
    Z35227.1 

    15 DOTS entries:

    DT.310854  DT.121223917  DT.95163415  DT.121223953  DT.95073024  DT.75123900  DT.121223958  DT.100695373 
    DT.100857545  DT.121223909  DT.121223937  DT.121223970  DT.433771  DT.95163414  DT.99983020 

    Selected AceView cDNA sequences (see all 104):

    BX447460 AY673956 CR607001 BU626663 NM_004310 BP367186 CD367666 BX404688 
    CD367697 BC014261 AL532319 AY673954 CR450349 BX421813 AY673953 CR619539 
    AY673955 BP338424 AF498975 BP366829 BI906690 BQ050403 BG684038 BX435747 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RHOH (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ·
    SP1:                                            -           -     -     -     -     -     -     -     -     -     -                 -     -                     
    SP2:                                            -     -     -     -     -     -     -                 -     -     -                 -     -                     
    SP3:                                            -     -     -     -     -     -     -     -     -     -           -                 -     -                     
    SP4:                                            -     -     -     -     -     -     -     -     -                 -                 -     -                     
    SP5:                                                        -     -                 -     -     -     -     -     -                 -     -                     

    ExUns: 10d · 10e · 10f · 10g
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RHOH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGGAAGA
    RHOH Expression
    About this image

    RHOH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654594

    UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
    Tissue specificity: Expressed only in hematopoietic cells. Present at very high levels in the thymus, less
    abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of
    T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as
    cystic fibrosis, ulcerative colitis and appendicitis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RHOH gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhoh1 , 5 ras homolog gene family, member H1, 5 90.58(n)1
    96.86(a)1
      5 (33.80 cM)5
    747341  NM_001081105.11  NP_001074574.11 
     658635695 
    chicken
    (Gallus gallus)
    Aves RHOH1 ras homolog family member H 79.41(n)
    84.29(a)
      428786  XM_004936114.1  XP_004936171.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOH6
    ras homolog family member H
    77(a)
    1 ↔ 1
    5(99975702-99976277)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rhoh1 ras homolog family member H 72.11(n)
    77.37(a)
      100145522  NM_001126963.1  NP_001120435.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rhoh1 ras homolog gene family, member H 67.91(n)
    76.6(a)
      553413  XM_005170943.1  XP_005171000.1 
    worm
    (Caenorhabditis elegans)
    Secernentea crp-16
    Protein CRP-1 (crp-1) mRNA, complete cds
    32(a)
    1 ↔ 1
    V(10478590-10480965) WBGene00012532


    ENSEMBL Gene Tree for RHOH (if available)
    TreeFam Gene Tree for RHOH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOH gene
    RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    Selected SIMAP similar genes for RHOH using alignment to 4 protein entries:     RHOH_HUMAN (see all proteins) (see all similar genes):
    ARHH    RHOJ    RHOQ    RAC2    RHOF    ARHG
    RHOG    CDC42    RHOC    RHOA    RAC3    RHOB
    RHOD    RHOV    RAC1    RHOU    RND2    ARHE

    Find genes that share paralogs with RHOH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOH (see all 1122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770494011,2
    F--40196539(+) CTTCTC/TTATGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs13175771,2
    C,F,A,H--40196549(-) CCCTGG/TATTCC 1 -- us2k122Minor allele frequency- T:0.18MN NS EA NA WA 2944
    rs68246321,2
    C,F,H--40196600(+) AGACCT/CCATGA 1 -- us2k111Minor allele frequency- C:0.05NS EA NA 1042
    rs1933016961,2
    --40196609(+) GATTCG/TGAGCT 1 -- us2k10--------
    rs1835657061,2
    --40196636(+) CCCGCC/GGGCAA 1 -- us2k10--------
    rs1133724861,2
    C--40196723(+) TGTAAG/TTAACC 1 -- us2k10--------
    rs119407601,2
    C,F,H--40196946(+) ACAGAG/TGATTt 1 -- us2k1 tfbs311Minor allele frequency- T:0.03NS EA NA WA 1214
    rs3701132801,2
    C--40197032(+) TTCCT-/CCTTCC 1 -- us2k10--------
    rs1454694131,2
    C--40197036(+) TCCTT-/CCCTC 
            
    CCCTC
    1 -- us2k10--------
    rs1134989331,2
    C,F--40197116(+) CTTGCT/CGTGTC 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for RHOH (40192673 - 40248587 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RHOH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv513656OTHER Inversion21212237
    nsv513655OTHER Inversion21212237

    Human Gene Mutation Database (HGMD): RHOH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOH
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602037    OMIM disorders: --

    UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
  • Note=A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation
    t(3;4)(q27;p11) with BCL6

  • 5 diseases for RHOH:    
    About MalaCards
    nodal marginal zone b-cell lymphoma    t-cell immunodeficiency with epidermodysplasia verruciformis    thyroid lymphoma    marginal zone b-cell lymphoma
    appendicitis


    Find genes that share disorders with RHOH           About GenesLikeMe

    1 Novoseek inferred disease relationship for RHOH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 9478968 (1)

    Genetic Association Database (GAD): RHOH
    Human Genome Epidemiology (HuGE) Navigator: RHOH (1 document)

    Export disorders for RHOH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOH gene, integrated from 10 sources (see all 103):
    (articles sorted by number of sources associating them with RHOH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TTF, a gene encoding a novel small G protein, fuses to the lymphoma- associated LAZ3 gene by t(3;4) chromosomal translocation. (PubMed id 7784061)1, 2, 3, 9 Dallery E.... Kerckaert J.-P. (Oncogene 1995)
    2. A genome-wide association study identifies two new risk loci for Graves' disease. (PubMed id 21841780)1, 4 Chu X....Song H.D. (Nat. Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. RhoH/TTF negatively regulates leukotriene production in neutrophils. (PubMed id 19414807)1, 2 Daryadel A.... Simon H.-U. (J. Immunol. 2009)
    5. Multiple Rho proteins regulate the subcellular targeting of PAK5. (PubMed id 17064668)1, 2 Wu X. and Frost J.A. (Biochem. Biophys. Res. Commun. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. (PubMed id 11809807)1, 2 Li X.... Lim B. (Mol. Cell. Biol. 2002)
    8. Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation. (PubMed id 15563831)1, 9 Lahousse S....GaliA"gue-Zouitina S. (Gene 2004)
    9. Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization. (PubMed id 9226377)1, 9 Dallery-Prudhomme E....Galiegue-Zouitina S. (Genomics 1997)
    10. Hypermutation of multiple proto-oncogenes in B-cell diffuse large- cell lymphomas. (PubMed id 11460166)1, 9 Pasqualucci L.... Dalla-Favera R. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 399 HGNC: 686 AceView: RHOH Ensembl:ENSG00000168421 euGenes: HUgn399
    ECgene: RHOH Kegg: 399 H-InvDB: RHOH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHOH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHOH gene:
    Search GeneIP for patents involving RHOH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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