Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOH Gene

protein-coding   GIFtS: 60
GCID: GC04P040192

Ras Homolog Family Member H

(Previous names: ras homolog gene family, member H)
(Previous symbol: ARHH)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Homolog Family Member H1 2     GTP-Binding Protein TTF2 3
ARHH1 2 3 5     Rho-Related GTP-Binding Protein RhoH2
TTF2 3 5     TTF, Translocation Three Four2
Ras Homolog Gene Family, Member H1 2     Translocation Three Four Protein3

External Ids:    HGNC: 6861   Entrez Gene: 3992   Ensembl: ENSG000001684217   OMIM: 6020375   UniProtKB: Q156693   

Export aliases for RHOH gene to outside databases

Previous GC identifers: GC04P040096 GC04P040021 GC04P039875 GC04P040198 GC04P039521


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOH Gene:
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing
enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of
cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal
translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome
3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in
multiple transcript variants that encode the same protein. (provided by RefSeq, May 2013)

GeneCards Summary for RHOH Gene: 
RHOH (ras homolog family member H) is a protein-coding gene. Diseases associated with RHOH include nodal marginal zone b-cell lymphoma, and t-cell immunodeficiency with epidermodysplasia verruciformis, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase inhibitor activity. An important paralog of this gene is RHOQ.

UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
Function: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical
regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and
activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent
activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by
promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial
for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast
cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for
the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity).
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities
of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils

Gene Wiki entry for RHOH (RhoH) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016297.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOH gene promoter:
         LHX3b/Lhx3b   p53   STAT5A   NF-AT   c-Ets-1   NF-AT4   NF-AT2   NF-AT3   LHX3a/Lhx3a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOH promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p13

RHOH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOH gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P040192:  view genomic region     (about GC identifiers)

Start:
40,192,673 bp from pter      End:
40,246,281 bp from pter
Size:
53,609 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoH precursor  
Size: 191 amino acids; 21331 Da
Subunit: Interacts with ZAP70 (via SH2 domains) and the interaction is enhanced by its phosphorylation by LCK.
Interacts with SYK and the interaction is enhanced by its phosphorylation by FYN (By similarity). Interacts with
GDI1 and GDI2. Interacts with PAK7/PAK5 (By similarity)
Subcellular location: Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Co-localizes
together with ZAP70 in the immunological synapse (By similarity)

Explore the universe of human proteins at neXtProt for RHOH: NX_Q15669

Explore proteomics data for RHOH at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine by LCK. Phosphorylated by FYN. Phosphorylation enhances the interactions with ZAP70 and
    SYK and is critical for its function in thymocyte development (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15669

  • RHOH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOH Protein Expression
    REFSEQ proteins (12 alternative transcripts): 
    NP_001265288.1  NP_001265289.1  NP_001265290.1  NP_001265291.1  NP_001265292.1  NP_001265293.1  NP_001265294.1  NP_001265295.1  
    NP_001265296.1  NP_001265297.1  NP_001265298.1  NP_004301.1  

    ENSEMBL proteins: 
     ENSP00000425010   ENSP00000423384   ENSP00000422241   ENSP00000426439   ENSP00000371219  
     ENSP00000420866  
    Reactome Protein details: Q15669
    Human Recombinant Protein Products for RHOH: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RHOH
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RHOH
    GenScript Custom Purified and Recombinant Proteins Services for RHOH
    Novus Biologicals RHOH Protein
    Novus Biologicals RHOH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHOH 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11809807
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--

    RHOH for ontologies           About GeneDecksing



    RHOH Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RHOH
    GenScript Custom Superior Antibodies Services for RHOH
    Novus Biologicals RHOH Antibodies
    Abcam antibodies for RHOH
    Cloud-Clone Corp. Antibodies for RHOH 
    ThermoFisher Antibody for RHOH
    LSBio Antibodies in human, mouse, rat for RHOH 

    Assay Products for RHOH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RHOH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RHOH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOH 
    Cloud-Clone Corp. CLIAs for RHOH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q15669

    ProtoNet protein and cluster: Q15669

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
    Domain: The region involved in interaction with ZAP70 is a non-canonical immunoreceptor tyrosine-based activation
    motif (ITAM) (By similarity)
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOH_HUMAN, Q15669
    Function: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical
    regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and
    activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent
    activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by
    promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial
    for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast
    cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for
    the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity).
    Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
    Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities
    of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils
    Induction: By CSF2/GM-CSF. Down-regulated by phorbol myristate acetate (PMA)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005095GTPase inhibitor activity NAS11809807
    GO:0005515protein binding IPI11809807
    GO:0005525GTP binding IDA11809807
    GO:0017048Rho GTPase binding NAS11809807
         
    RHOH for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rhoh):
     cellular  hematopoietic system  immune system 

    RHOH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RHOH: Rhohtm1Brak Rhohtm1Daw

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOH 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOH
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOH:
    hsa-miR-3163 hsa-miR-612 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidRHOH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOH
    Sirion Biotech Customized adenovirus for overexpression of RHOH

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RHOH (see all 7)
    OriGene ORF clones in mouse, rat for RHOH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOH (NM_004310)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOH
    Sirion Biotech Customized lentivirus for stable overexpression of RHOH 
                         Customized lentivirus expression plasmids for stable overexpression of RHOH 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RHOH
    Search LifeMap BioReagents cell lines for RHOH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHOH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.55
    3Leukocyte transendothelial migration
    Leukocyte transendothelial migration

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for RHOH
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle


    1         Kegg Pathway  (Kegg details for RHOH):
        Leukocyte transendothelial migration


    RHOH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHOH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for RHOH (Q156692, 3 ENSP000003712194) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNH2Q128092, 3, ENSP000002621864MINT-64255 I2D: score=3 STRING: ENSP00000262186
    RHOAP615862, 3, ENSP000004001754MINT-56521 I2D: score=1 STRING: ENSP00000400175
    LRIF1Q5T3J32, 3MINT-64257 I2D: score=4 
    UTP14AQ9BVJ62, 3MINT-64256 I2D: score=4 
    ARHGDIGQ998193, ENSP000002194094I2D: score=2 STRING: ENSP00000219409
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006355regulation of transcription, DNA-dependent NAS11809807
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport ----

    RHOH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOH

    7 Novoseek inferred chemical compound relationships for RHOH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geranylgeranyl pyrophosphate 64.9 1 11390424 (1)
    gtp 54.3 10 9451818 (1), 14992721 (1), 10676816 (1), 9780206 (1) (see all 9)
    gdp 51.2 1 8798610 (1)
    toxin a 49 1 8944363 (1)
    mevalonate 47.2 1 11390424 (1)
    actomyosin 38.9 1 9478968 (1)
    tyrosine 19.2 1 10652228 (1)

    Search CenterWatch for drugs/clinical trials and news about RHOH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHOH gene (12 alternative transcripts): 
    NM_001278359.1  NM_001278360.1  NM_001278361.1  NM_001278362.1  NM_001278363.1  NM_001278364.1  NM_001278365.1  NM_001278366.1  
    NM_001278367.1  NM_001278368.1  NM_001278369.1  NM_004310.4  

    Unigene Cluster for RHOH:

    Ras homolog family member H
    Hs.654594  [show with all ESTs]
    Unigene Representative Sequence: AK097117
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505618 ENST00000507851 ENST00000503754 ENST00000508513 ENST00000511967
    ENST00000503941 ENST00000381799(uc003guz.2) ENST00000514839 ENST00000513894
    ENST00000515702 ENST00000515718 ENST00000515503 ENST00000514143 ENST00000504638
    ENST00000511121 ENST00000503978
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOH
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOH:
    hsa-miR-3163 hsa-miR-612 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidRHOH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOH
    Clone
    Products:
         
    OriGene clones in human, mouse for RHOH (see all 7)
    OriGene ORF clones in mouse, rat for RHOH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOH (NM_004310)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOH
    Sirion Biotech Customized lentivirus for stable overexpression of RHOH 
                         Customized lentivirus expression plasmids for stable overexpression of RHOH 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOH
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOH

    Additional mRNA sequence: 

    AF498975.1 AK097117.1 AK313744.1 AY673952.1 AY673953.1 AY673956.1 BC014261.2 CR450349.1 
    Z35227.1 

    15 DOTS entries:

    DT.310854  DT.121223917  DT.95163415  DT.121223953  DT.95073024  DT.75123900  DT.121223958  DT.100695373 
    DT.100857545  DT.121223909  DT.121223937  DT.121223970  DT.433771  DT.95163414  DT.99983020 

    24/104 AceView cDNA sequences (see all 104):

    CD367697 AY673953 BP338424 AY673954 NM_004310 BC014261 AF498975 BX447460 
    CR607001 AL532319 BX421813 AY673956 BX404688 BP367186 AY673955 CR619539 
    CD367666 BU626663 CR450349 BE675971 AI862386 BG684038 BI832803 AA767445 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RHOH (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ·
    SP1:                                            -           -     -     -     -     -     -     -     -     -     -                 -     -                     
    SP2:                                            -     -     -     -     -     -     -                 -     -     -                 -     -                     
    SP3:                                            -     -     -     -     -     -     -     -     -     -           -                 -     -                     
    SP4:                                            -     -     -     -     -     -     -     -     -                 -                 -     -                     
    SP5:                                                        -     -                 -     -     -     -     -     -                 -     -                     

    ExUns: 10d · 10e · 10f · 10g
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RHOH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGGAAGA
    RHOH Expression
    About this image


    See RHOH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOH

    SOURCE GeneReport for Unigene cluster: Hs.654594

    UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
    Tissue specificity: Expressed only in hematopoietic cells. Present at very high levels in the thymus, less
    abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of
    T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as
    cystic fibrosis, ulcerative colitis and appendicitis

        SABiosciences Custom PCR Arrays for RHOH
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHOH
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RHOH gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhoh1 , 5 ras homolog gene family, member H1, 5 90.58(n)1
    96.86(a)1
      5 (33.80 cM)5
    747341  NM_001081105.11  NP_001074574.11 
     658635695 
    chicken
    (Gallus gallus)
    Aves RHOH1 ras homolog gene family, member H 79.41(n)
    84.29(a)
      428786  XM_426342.3  XP_426342.2 
    lizard
    (Anolis carolinensis)
    Reptilia RHOH6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    5(99975702-99976277)
    zebrafish
    (Danio rerio)
    Actinopterygii rhoh1 ras homolog gene family, member H 67.91(n)
    76.6(a)
      553413  XM_002660452.1  XP_002660498.1 


    ENSEMBL Gene Tree for RHOH (if available)
    TreeFam Gene Tree for RHOH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOH gene
    RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    18/62 SIMAP similar genes for RHOH using alignment to 4 protein entries:     RHOH_HUMAN (see all proteins) (see all similar genes):
    ARHH    RHOJ    RHOQ    RAC2    RHOF    ARHG
    RHOG    CDC42    RHOA    RHOC    RAC3    RHOB
    RHOD    RHOV    RAC1    RHOU    RND2    ARHE

    RHOH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1122 SNPs in RHOH are shown (see all 1122)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770494011,2
    F--40196539(+) CTTCTC/TTATGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs13175771,2
    C,F,A,H--40196549(-) CCCTGG/TATTCC 1 -- us2k122Minor allele frequency- T:0.18MN NS EA NA WA 2944
    rs68246321,2
    C,F,H--40196600(+) AGACCT/CCATGA 1 -- us2k111Minor allele frequency- C:0.05NS EA NA 1042
    rs1933016961,2
    --40196609(+) GATTCG/TGAGCT 1 -- us2k10--------
    rs1835657061,2
    --40196636(+) CCCGCC/GGGCAA 1 -- us2k10--------
    rs1133724861,2
    C--40196723(+) TGTAAG/TTAACC 1 -- us2k10--------
    rs119407601,2
    C,F,H--40196946(+) ACAGAG/TGATTt 1 -- us2k1 tfbs311Minor allele frequency- T:0.03NS EA NA WA 1214
    rs3701132801,2
    C--40197032(+) TTCCT-/CCTTCC 1 -- us2k10--------
    rs1454694131,2
    C--40197036(+) TCCTT-/CCCTC 
            
    CCCTC
    1 -- us2k10--------
    rs1134989331,2
    C,F--40197116(+) CTTGCT/CGTGTC 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for RHOH (40192673 - 40246281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RHOH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv513656OTHER Inversion21212237
    nsv513655OTHER Inversion21212237


    Human Gene Mutation Database (HGMD): RHOH
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOH
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602037    OMIM disorders: --

    UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
  • Note=A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation
    t(3;4)(q27;p11) with BCL6

  • 20/24 diseases for RHOH (see all 24):    About MalaCards
    nodal marginal zone b-cell lymphoma    t-cell immunodeficiency with epidermodysplasia verruciformis    non-hodgkin lymphoma    clostridium difficile
    hodgkin's lymphoma    marginal zone b-cell lymphoma    b-cell lymphomas    appendicitis
    hairy cell leukemia    diffuse large b-cell lymphoma    chronic lymphocytic leukemia    malignant glioma
    ulcerative colitis    t-cell leukemia    graves' disease    multiple myeloma
    cystic fibrosis    kidney disease    myeloma    pancreatic cancer


    RHOH for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RHOH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 9478968 (1)

    Genetic Association Database (GAD): RHOH
    Human Genome Epidemiology (HuGE) Navigator: RHOH (1 document)

    Export disorders for RHOH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOH gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with RHOH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TTF, a gene encoding a novel small G protein, fuses to the lymphoma- associated LAZ3 gene by t(3;4) chromosomal translocation. (PubMed id 7784061)1, 2, 3, 9 Dallery E.... Kerckaert J.-P. (1995)
    2. A genome-wide association study identifies two new ris k loci for Graves' disease. (PubMed id 21841780)1, 4 Chu X....Song H.D. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. RhoH/TTF negatively regulates leukotriene production in neutrophils. (PubMed id 19414807)1, 2 Daryadel A.... Simon H.-U. (2009)
    5. Multiple Rho proteins regulate the subcellular target ing of PAK5. (PubMed id 17064668)1, 2 Wu X. and Frost J.A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. (PubMed id 11809807)1, 2 Li X.... Lim B. (2002)
    8. Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation. (PubMed id 15563831)1, 9 Lahousse S....Galiegue-Zouitina S. (2004)
    9. Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization. (PubMed id 9226377)1, 9 Dallery-Prudhomme E....Galiegue-Zouitina S. (1997)
    10. Hypermutation of multiple proto-oncogenes in B-cell diffuse large- cell lymphomas. (PubMed id 11460166)1, 9 Pasqualucci L.... Dalla-Favera R. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 399 HGNC: 686 AceView: RHOH Ensembl:ENSG00000168421 euGenes: HUgn399
    ECgene: RHOH Kegg: 399 H-InvDB: RHOH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHOH gene:
    Search GeneIP for patents involving RHOH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RHOH  
     OriGene qPCR primer pairs and template standards for RHOH   OriGene Protein Over-expression Lysate for RHOH  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RHOH  
     OriGene qSTAR qPCR primer pairs in human, mouse for RHOH   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RHOH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RHOH   OriGene Custom Protein Services for RHOH  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHOH
     QIAGEN SeqTarget long-range PCR primers for resequencing RHOH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOH
     GenScript Custom Purified and Recombinant Proteins Services for RHOH GenScript cDNA clones with any tag delivered in your preferred vector for RHOH
     GenScript Custom Assay Services for RHOH GenScript Custom Superior Antibodies Services for RHOH
     GenScript Custom overexpressing Cell Line Services for RHOH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RHOH promoter
     Search Chromatin IP Primers for RHOH
     RT2 qPCR Primer Assay in human, mouse, rat RHOH
     Search GNC Networks for RHOH
     SABiosciences Custom PCR Arrays for RHOH
     Search Tocris compounds for RHOH
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RHOH antibodies
     RHOH proteins
     RHOH lysates
     Antibodies for RHOH
     See all of Abcam's Antibodies, Kits and Proteins for RHOH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RHOH
     Antibodies for RHOH
     ELISAs for RHOH
     CLIAs for RHOH
     Search LifeMap BioReagents cell lines for RHOH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOH
     SwitchGear 3'UTR luciferase reporter plasmids for RHOH
     SwitchGear Promoter luciferase reporter plasmids for RHOH
     ThermoFisher Antibody for RHOH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOH
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOH
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOH
    Customized:
     lentivirus for stable overexpression of RHOH
     lentivirus expression plasmids for stable overexpression of RHOH
     adenovirus for overexpression of RHOH
     LSBio Antibodies in human, mouse, rat for RHOH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RHOH gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4