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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOG Gene

protein-coding   GIFtS: 59
GCID: GC11M003848

ras homolog family member G

(Previous names: ras homolog gene family, member G (rho G) )
(Previous symbol: ARHG)
 Explore 6 diseases affiliated with
RHOG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RHOG    

Aliases
for RHOG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ras Homolog Family Member G1 2     MGC1258361
ARHG1 2 3 5     RhoG1
Ras Homolog Gene Family, Member G (Rho G)1 2     Rho-Related GTP-Binding Protein RhoG2
MGC1258351     

External Ids:    HGNC: 6721   Entrez Gene: 3912   Ensembl: ENSG000001771057   OMIM: 1795055   UniProtKB: P840953   

Export aliases for RHOG gene to outside databases

Previous GC identifers: GC11M003813 GC11M003804 GC11M003581


Summaries
for RHOG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RHOG:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active
GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote
reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein
facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the
plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and
cell migration. Two related pseudogene have been identified on chromosomes 20 and X. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095
Function: Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is
required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of
Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and
promotes bacterial entry

Gene Wiki entry for RHOG (RhoG)


Genomic Views
for RHOG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOG gene promoter:
         SRF   MAZR   AP-1   SRF (504 AA)   ATF-2   FOXJ2 (long isoform)   FOXJ2   c-Jun   NF-kappaB1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RHOG promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5-p15.4

RHOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOG gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003848:  view genomic region     (about GC identifiers)

Start:
 3,848,208 bp from pter      End:
 3,862,213 bp from pter
Size:
 14,006 bases      Orientation:
 minus strand

Proteins
for RHOG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoG precursor  
Size: 191 amino acids; 21309 Da
Subunit: Interacts with ARHGEF26. Interacts with ARHGEF16
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: P35238 Q8NI04

Explore the universe of human proteins at neXtProt for RHOG: NX_P84095

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P84095

    • RHOG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001656.2  
    ENSEMBL proteins: 
     ENSP00000339467   ENSP00000380176   ENSP00000380175   ENSP00000436932  
    Reactome Protein details: P84095
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: RHOG
    OriGene Custom Protein Services for RHOG 
    GenScript Custom Purified and Recombinant Proteins Services for RHOG
    Novus Biologicals RHOG Proteins
    Novus Biologicals RHOG Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for RHOG
    Uscn Proteins for RHOG

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--


    RHOG for ontologies           About GeneDecksing



    RHOG Antibody Products: 
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    Novus Biologicals RHOG Antibodies
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    Uscn Antibodies for RHOG
    Search ThermoFisher Antibodies for RHOG

    Assay Products for RHOG: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for RHOG

    Protein Domains /
    Families
    for RHOG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RHOG for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase

    Graphical View of Domain Structure for InterPro Entry P84095

    ProtoNet protein and cluster: P84095

    UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Function
    for RHOG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095
    Function: Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is
    required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of
    Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and
    promotes bacterial entry

    miRNA
    Products:            		miRTarBase miRNAs that target RHOG:
    hsa-let-7b (MIRT001598)

    OriGene 3'-UTR Clone: RHOG
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOG
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOG (see all 20):
    hsa-miR-3910 hsa-miR-199b-3p hsa-miR-2909 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-331-3p hsa-miR-3150a-3p hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmid: RHOG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOG (see all 7)
    OriGene shRNA RFP: RHOG
    OriGene siRNA: RHOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOG

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RHOG

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOG (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOG
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RHOG (NM_001665)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOG 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RHOG
    Search LifeMap BioReagents cell lines for RHOG

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RHOG

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA12376551
    GO:0005515protein binding IPI12879077
    GO:0005525GTP binding IEA--


    RHOG for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RHOG:
     Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-out Rhogtm1Tnr for RHOG
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rhog):
     cellular  hematopoietic system  immune system  nervous system 

    RHOG for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RHOG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sema4D in semaphorin signaling
    		Sema4D in semaphorin signaling1.00
    		Semaphorin interactions0.44
    		Sema4D induced cell migration and growth-cone collapse0.83
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Cell death signalling via NRAGE, NRIF and NADE
    		G alpha (12/13) signalling events0.39
    		Signaling by Rho GTPases0.25
    		Rho GTPase cycle0.25
    4Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    5Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for RHOG 
        Neurotrophic factor-mediated Trk receptor signaling

    5/14        Reactome Pathways for RHOG (see all 14)
        GPCR downstream signaling
    Hemostasis
    Signaling by Rho GTPases
    Developmental Biology
    G alpha (12/13) signalling events


    2         Kegg Pathways  (Kegg details for RHOG):
        Bacterial invasion of epithelial cells
    Shigellosis


    RHOG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for RHOG (P840951, 3 ENSP000003394674) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELMO1Q925561, 3, ENSP000003121854EBI-446579,EBI-346417 I2D: score=4 STRING: ENSP00000312185
    MAP3K11Q165843, ENSP000003095974I2D: score=3 STRING: ENSP00000309597
    ARHGDIGQ998193, ENSP000002194094I2D: score=2 STRING: ENSP00000219409
    VAV1P154983, ENSP000003022694I2D: score=2 STRING: ENSP00000302269
    VAV2P527353, ENSP000003609164I2D: score=2 STRING: ENSP00000360916
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS1620121
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction IDA12376551
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--


    RHOG for ontologies           About GeneDecksing



    Drugs & Compounds
    for RHOG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOG
    2 Novoseek chemical compound relationships for RHOG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 65.7 1 8939998 (1)
    gtp 55.1 2 8939998 (2)

    Search CenterWatch for drugs/clinical trials and news about RHOG 

    Transcripts
    for RHOG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RHOG gene: 
    NM_001665.3  

    Unigene Cluster for RHOG:

    Ras homolog family member G
    Hs.501728  [show with all ESTs]
    Unigene Representative Sequence: BM912141
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351018(uc001lyu.2) ENST00000396979 ENST00000396978 ENST00000533217


    miRNA
    Products:             		 OriGene 3'-UTR Clone: RHOG
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOG
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOG (see all 20):
    hsa-miR-3910 hsa-miR-199b-3p hsa-miR-2909 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-331-3p hsa-miR-3150a-3p hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmid: RHOG 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOG (see all 7)
    OriGene shRNA RFP: RHOG
    OriGene siRNA: RHOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOG
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOG (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOG
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RHOG (NM_001665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOG 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOG
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOG

    Additional cDNA sequence: 

    AF498974.1 AY563952.1 BC104177.2 BC104178.2 BT019872.1 CR450335.1 CR542105.1 L11317.1 
    X61587.1 

    7 DOTS entries:

    DT.95308177  DT.100761948  DT.316427  DT.100652041  DT.92429039  DT.86851986  DT.95149185 

    24/289 AceView cDNA sequences (see all 289):

    BM912761 BM851558 BQ942142 CB149318 AI288206 BU632944 BQ055598 AY563952 
    BM769032 CA426002 AW027360 CD674008 CF127555 BU629055 BI753210 CR625567 
    CR625234 BG119083 BU617808 CR542105 BM553386 BM423979 CD674007 NM_001665 

    GeneLoc Exon Structure


    Expression
    for RHOG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTCTGGGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RHOG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RHOG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOG

    SOURCE GeneReport for Unigene cluster: Hs.501728
        SABiosciences Custom PCR Arrays for RHOG
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOG
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RHOG

    Orthologs
    for RHOG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RHOG gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008595991 rho-related GTP-binding protein RhoG-like 80.45(n)
    84.82(a)    		   100859599  XM_003640618.1  XP_003640666.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RHOG6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343900.1(132169-132744)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC689332 hypothetical protein MGC68933 80.94(n)    BC059300.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufk30f012 wufk30f01 77.73(n)   336933  BC044508.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mtl6
    		 Mig-2-like
    		 65(a)
    		 1 ↔ 1
    		 3R(23462134-23465593)
    worm
    (Caenorhabditis elegans)    		 Secernentea mig-26
    		 abnormal cell MIGration family member (mig-2)
    		 59(a)
    		 1 ↔ 1
    		 X(11548542-11550634)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ROP16
    ATROP46
    (see all 11)    		 Rac-like GTP-binding protein ARAC5
    (see all 11)    		 54(a)
    54(a)
    (see all 11)    		 many ↔ many
    many ↔ many
    (see all 11)    		 3(19042887-19044372)
    1(28475707-28477802)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 ras-related protein, putative, expressed
    (see all 9)    		 54(a)
    54(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 2(1080513-1084283)
    2(12324543-12326740)


    ENSEMBL Gene Tree for RHOG (if available)
    TreeFam Gene Tree for RHOG (if available) 

    Paralogs
    for RHOG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOG gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    18/43 SIMAP similar genes for RHOG using alignment to 1 protein entry:     RHOG_HUMAN(see all similar genes):
    ARHG    RAC3    CDC42    RAC1    RAC2    RHOB
    RHOQ    RHOV    RHOA    RHOJ    RHOC    RHOF
    RHOU    RHOD    RHOH    ARHE    RND3    RND2

    RHOG for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RHOG
    PGOHUM00000247454 PGOHUM00000241380 PGOHUM00000241834


    Genomic Variants
    for RHOG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/327 NCBI SNPs in RHOG are shown (see all 327)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs49105771,2
    		C,F,H,--3847750(+) NNNNTA/GTTTTG 17 -- int131Minor allele frequency- G:0.15NA NS EA WA CSA 2887
    rs1830972251,2
    		--3847776(+) TGAGCC/TATCTG 17 -- int10--------
    rs1419245891,2
    		--3847934(+) CTTTAA/GACTAA 17 -- int10--------
    rs1462983591,2
    		--3847960(+) CCCTTC/TCTGAG 17 -- int10--------
    rs1867150361,2
    		--3848046(+) AGACTA/GCCCCC 17 -- int10--------
    rs49108521,2
    		C,F,A,H,--3848086(+) AATTGA/GGGGGT 17 -- int111Minor allele frequency- G:0.11NS EA NA WA CSA 638
    rs1393199681,2
    		--3848162(+) CCTAGC/TCCATG 1 -- int10--------
    rs122762711,2
    		F,H,--3848175(+) CACCCG/ACTAAT 1 -- int16Minor allele frequency- A:0.00NS EA CSA 420
    rs1841043211,2
    		--3848243(+) ATGGGA/GGTAGG 1 -- ut310--------
    rs171738791,2
    		C,F,H,--3848294(+) TGCGTA/GAGGCC 1 -- ut3110Minor allele frequency- G:0.01NA NS EA WA 684

    HapMap Linkage Disequilibrium report for RHOG (3848208 - 3862213 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RHOG: --
    Human Gene Mutation Database (HGMD): RHOG

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    Disorders / Diseases
    for RHOG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RHOG for disorders           About GeneDecksing

    OMIM gene information: 179505    OMIM disorders: --

    6 diseases for RHOG:    About MalaCards
    tangier disease    intrahepatic cholangiocarcinoma    shigellosis    cholangiocarcinoma
    cholesterol    thyroiditis

    Human Genome Epidemiology (HuGE) Navigator: RHOG (5 documents)

    Export disorders for RHOG gene to outside databases

    Publications
    for RHOG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOG gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with RHOG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Ephexin4 and EphA2 mediate cell migration through a R hoG-dependent mechanism. (PubMed id 20679435)1, 2 Hiramoto-Yamaki N....Katoh H. (2010)
    2. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. (PubMed id 17875742)1, 2 van Buul J.D....Burridge K. (2007)
    3. Oncogene ect2 is related to regulators of small GTP-binding proteins. (PubMed id 8464478)1, 2 Miki T.... Fleming T.P. (1993)
    4. Localization of ARHG, a member of the RAS homolog gene family, to 11p15.5-11p15.4 by fluorescence in situ hybridization. (PubMed id 8325658)1, 3 Taviaux S.A....Demaille J.G. (1993)
    5. Growth-regulated expression of rhoG, a new member of the ras homolog gene family. (PubMed id 1620121)1, 2 Vincent S.... Fort P. (1992)
    6. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. (PubMed id 15199069)1, 9 Skowronek K.R....Nassar N. (2004)
    7. Structure of the human ARHG locus encoding the Rho/Rac-like RhoG GTPase. (PubMed id 9177787)1, 9 Le Gallic L. and Fort P. (1997)
    8. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. (PubMed id 8939998)1, 9 Zalcman G....Olofsson B. (1996)
    9. The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH. (PubMed id 22251971)1 Wong A.R....Frankel G. (2012)
    10. The invasive capacity of HPV transformed cells require s the hDlg-dependent enhancement of SGEF/RhoG activity. (PubMed id 22383878)1 Krishna Subbaiah V....Banks L. (2012)

    External Searches for RHOG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing RHOG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 391 HGNC: 672 AceView: RHOG Ensembl:ENSG00000177105 euGenes: HUgn391
    ECgene: RHOG Kegg: 391 H-InvDB: RHOG

    Other Databases showing RHOG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RHOG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOG Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RHOG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RHOG gene:
    Search GeneIP for patents involving RHOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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