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RHOG Gene

protein-coding   GIFtS: 63
GCID: GC11M003848

Ras Homolog Family Member G

(Previous names: ras homolog gene family, member G (rho G))
(Previous symbol: ARHG)
  See RHOG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member G1 2
ARHG1 2 3 5
Ras Homolog Gene Family, Member G (Rho G)1 2
Rho-Related GTP-Binding Protein RhoG2

External Ids:    HGNC: 6721   Entrez Gene: 3912   Ensembl: ENSG000001771057   OMIM: 1795055   UniProtKB: P840953   

Export aliases for RHOG gene to outside databases

Previous GC identifers: GC11M003813 GC11M003804 GC11M003581


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHOG Gene:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active
GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote
reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein
facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to
the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium
formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. (provided by
RefSeq, Aug 2011)

GeneCards Summary for RHOG Gene:
RHOG (ras homolog family member G) is a protein-coding gene. Diseases associated with RHOG include shigellosis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095
Function: Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration
and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In
case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton
rearrangements and promotes bacterial entry

summary for RHOG Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for RHOG (RhoG) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOG gene promoter:
         SRF   MAZR   AP-1   SRF (504 AA)   ATF-2   FOXJ2 (long isoform)   FOXJ2   c-Jun   NF-kappaB1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RHOG promoter sequence
   Search Chromatin IP Primers for RHOG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5-p15.4

RHOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOG gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003848:  view genomic region     (about GC identifiers)

Start:
3,848,208 bp from pter      End:
3,862,213 bp from pter
Size:
14,006 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoG precursor  
Size: 191 amino acids; 21309 Da
Subunit: Interacts with ARHGEF26. Interacts with ARHGEF16
Secondary accessions: P35238 Q8NI04

Explore the universe of human proteins at neXtProt for RHOG: NX_P84095

Explore proteomics data for RHOG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys130, Lys147, Lys183
  • Modification sites at PhosphoSitePlus

  • See RHOG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001656.2  
    ENSEMBL proteins: 
     ENSP00000339467   ENSP00000380176   ENSP00000380175   ENSP00000436932  
    Reactome Protein details: P84095

    RHOG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RHOG
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RHOG
    GenScript Custom Purified and Recombinant Proteins Services for RHOG
    Novus Biologicals RHOG Proteins
    Novus Biologicals RHOG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RHOG
    Cloud-Clone Corp. Proteins for RHOG

     
    Search eBioscience for Proteins for RHOG 

     
    antibodies-online proteins for RHOG (6 products) 

     
    antibodies-online peptides for RHOG

    RHOG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RHOG
    Browse R&D Systems for Antibodies
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    Novus Biologicals RHOG Antibodies
    Abcam antibodies for RHOG
    Cloud-Clone Corp. Antibodies for RHOG
    Search ThermoFisher Antibodies for RHOG
    antibodies-online antibodies for RHOG (33 products) 

    RHOG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RHOG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOG
    Cloud-Clone Corp. CLIAs for RHOG
    Search eBioscience for ELISAs for RHOG 
    antibodies-online kits for RHOG (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P84095

    ProtoNet protein and cluster: P84095

    UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RHOG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOG_HUMAN, P84095
    Function: Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration
    and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In
    case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton
    rearrangements and promotes bacterial entry

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA12376551
    GO:0005515protein binding IPI12879077
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RHOG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RHOG:
     Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhog):
     hematopoietic system  immune system  nervous system 

    Find genes that share phenotypes with RHOG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rhogtm1Tnr for RHOG

       genOway: Develop your customized and physiologically relevant rodent model for RHOG

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOG:
    hsa-mir-124-3p (MIRT002922), hsa-let-7b-5p (MIRT001598)

    Block miRNA regulation of human, mouse, rat RHOG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOG (see all 20):
    hsa-miR-3910 hsa-miR-199b-3p hsa-miR-2909 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-331-3p hsa-miR-3150a-3p hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmidRHOG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RHOG
    Predesigned siRNA for gene silencing in human, mouse, rat RHOG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOG

    Clone
    Products:
         
    OriGene clones in human, mouse for RHOG (see all 6)
    OriGene ORF clones in mouse, rat for RHOG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOG (NM_001665)
    Sino Biological Human cDNA Clone for RHOG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RHOG
    Browse ESI BIO Cell Lines and PureStem Progenitors for RHOG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOG_HUMAN, P84095: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with RHOG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOG About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90
    3L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    4Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    5Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43


    Find genes that share SuperPaths with RHOG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RHOG (see all 35)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    TRKA Signaling
    Tec Kinases Signaling

    2 BioSystems Pathways for RHOG
        BDNF signaling pathway
    Neurotrophic factor-mediated Trk receptor signaling


    4 Reactome Pathways for RHOG
        Sema4D induced cell migration and growth-cone collapse
    G alpha (12/13) signalling events
    Rho GTPase cycle
    GPVI-mediated activation cascade


    3 Kegg Pathways  (Kegg details for RHOG):
        Bacterial invasion of epithelial cells
    Shigellosis
    Salmonella infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHOG
    Interactions:

        GeneGlobe Interaction Network for RHOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOG (P840951, 3 ENSP000003394674) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELMO1Q925561, 3, ENSP000003121854EBI-446579,EBI-346417 I2D: score=4 STRING: ENSP00000312185
    MAP3K11Q165843, ENSP000003095974I2D: score=3 STRING: ENSP00000309597
    ARHGDIGQ998193, ENSP000002194094I2D: score=2 STRING: ENSP00000219409
    VAV1P154983, ENSP000003022694I2D: score=2 STRING: ENSP00000302269
    VAV2P527353, ENSP000003609164I2D: score=2 STRING: ENSP00000360916
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS1620121
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with RHOG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RHOG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    2 Novoseek inferred chemical compound relationships for RHOG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 65.7 1 8939998 (1)
    gtp 55.1 2 8939998 (2)



    Find genes that share compounds with RHOG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHOG gene: 
    NM_001665.3  

    Unigene Cluster for RHOG:

    Ras homolog family member G
    Hs.501728  [show with all ESTs]
    Unigene Representative Sequence: BM912141
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351018(uc001lyu.2) ENST00000396979 ENST00000396978 ENST00000533217

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RHOG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOG (see all 20):
    hsa-miR-3910 hsa-miR-199b-3p hsa-miR-2909 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-331-3p hsa-miR-3150a-3p hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmidRHOG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RHOG
    Predesigned siRNA for gene silencing in human, mouse, rat RHOG
    Clone
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    OriGene clones in human, mouse for RHOG (see all 6)
    OriGene ORF clones in mouse, rat for RHOG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOG (NM_001665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOG
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOG
      QuantiTect SYBR Green Assays in human, mouse, rat RHOG
      QuantiFast Probe-based Assays in human, mouse, rat RHOG

    Additional mRNA sequence: 

    AF498974.1 AY563952.1 BC104177.2 BC104178.2 BT019872.1 CR450335.1 CR542105.1 L11317.1 
    X61587.1 

    7 DOTS entries:

    DT.95308177  DT.100761948  DT.316427  DT.100652041  DT.92429039  DT.86851986  DT.95149185 

    Selected AceView cDNA sequences (see all 289):

    AI199459 BU632944 CB106985 CA426002 CR542105 BM915350 AA811659 NM_001665 
    BI754469 BM423979 BM829983 BQ055598 BG119083 AY563952 CR611277 CF127555 
    AI222752 CR616579 CR611274 BP353272 BM851558 CB136319 BU540919 BQ688619 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTGGGGA
    RHOG Expression
    About this image


    RHOG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Spleen (Hematopoietic System)
    RHOG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501728
        Custom PCR Arrays for RHOG
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHOG
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOG
    QuantiTect SYBR Green Assays in human, mouse, rat RHOG
    QuantiFast Probe-based Assays in human, mouse, rat RHOG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RHOG gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhog1 , 5 ras homolog gene family, member G1, 5 90.92(n)1
    100(a)1
      7 (54.71 cM)5
    562121  NM_019566.31  NP_062512.11 
     1022391235 
    chicken
    (Gallus gallus)
    Aves LOC1008595991 rho-related GTP-binding protein RhoG-like 80.45(n)
    84.82(a)
      100859599  XM_004938980.1  XP_004939037.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOG6
    ras homolog family member G
    83(a)
    1 ↔ 1
    GL343900.1(132169-132744)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689332 hypothetical protein MGC68933 80.94(n)    BC059300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk30f012 wufk30f01 77.73(n)   336933  BC044508.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rac16
    Rac26
    Rac2
    68(a)
    67(a)
    many ↔ many
    many ↔ many
    3L(1300879-1302683)
    3L(7426749-7428290)
    worm
    (Caenorhabditis elegans)
    Secernentea ced-106
    Protein CED-10, isoform a (ced-10) mRNA, complete ...
    67(a)
    many ↔ many
    IV(3506404-3509529) WBGene00000424


    ENSEMBL Gene Tree for RHOG (if available)
    TreeFam Gene Tree for RHOG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOG gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    Selected SIMAP similar genes for RHOG using alignment to 1 protein entry:     RHOG_HUMAN(see all similar genes):
    ARHG    RAC3    CDC42    RAC1    RAC2    RHOB
    RHOQ    RHOV    RHOA    RHOJ    RHOC    RHOF
    RHOU    RHOD    RHOH    ARHE    RND3    RND2

    Find genes that share paralogs with RHOG           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for RHOG
    PGOHUM00000247454 PGOHUM00000241380 PGOHUM00000241834


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOG (see all 378)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1879402381,2
    --3787226(+) AAATGC/TGGTGT 1 -- int10--------
    rs1488099261,2
    --3787292(+) TAGCAC/TGTGTA 1 -- int10--------
    rs1393199681,2
    --3848162(+) CCTAGC/TCCATG 1 -- int10--------
    rs122762711,2
    F,H--3848175(+) CACCCG/ACTAAT 1 -- int16Minor allele frequency- A:0.00NS EA CSA 420
    rs1841043211,2
    --3848243(+) ATGGGA/GGTAGG 1 -- ut310--------
    rs171738791,2
    C,F,H--3848294(+) TGCGTA/GAGGCC 1 -- ut3110Minor allele frequency- G:0.01NA NS EA WA 684
    rs10493881,2
    C,F,A,H--3848373(-) ATGCTC/GTCTCC 1 -- ut31 ese3 trp314Minor allele frequency- G:0.09MN NS EA NA WA CSA 847
    rs1495871431,2
    --3848475(+) ACTGTA/GTGGAA 1 -- ut310--------
    rs122899891,2
    C,H--3848492(+) ATGAAC/ATGGTC 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs1119840621,2
    C--3848731(+) CGGACA/GAGGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RHOG (3848208 - 3862213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RHOG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv896894CNV Loss21882294

    Human Gene Mutation Database (HGMD): RHOG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOG
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179505    OMIM disorders: --

    1 disease for RHOG:    
    About MalaCards
    shigellosis


    Find genes that share disorders with RHOG           About GenesLikeMe

    Genetic Association Database (GAD): RHOG
    Human Genome Epidemiology (HuGE) Navigator: RHOG (5 documents)

    Export disorders for RHOG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOG gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with RHOG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    2. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. (PubMed id 20679435)1, 2 Hiramoto-Yamaki N.... Katoh H. (J. Cell Biol. 2010)
    3. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    4. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. (PubMed id 17875742)1, 2 van Buul J.D.... Burridge K. (J. Cell Biol. 2007)
    5. Oncogene ect2 is related to regulators of small GTP-binding proteins. (PubMed id 8464478)1, 2 Miki T.... Fleming T.P. (Nature 1993)
    6. Localization of ARHG, a member of the RAS homolog gene family, to 11p15.5-11p15.4 by fluorescence in situ hybridization. (PubMed id 8325658)1, 3 Taviaux S.A....Demaille J.G. (Genomics 1993)
    7. Growth-regulated expression of rhoG, a new member of the ras homolog gene family. (PubMed id 1620121)1, 2 Vincent S.... Fort P. (Mol. Cell. Biol. 1992)
    8. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. (PubMed id 15199069)1, 9 Skowronek K.R....Nassar N. (J. Biol. Chem. 2004)
    9. Structure of the human ARHG locus encoding the Rho/Rac-like RhoG GTPase. (PubMed id 9177787)1, 9 Le Gallic L. and Fort P. (Genomics 1997)
    10. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. (PubMed id 8939998)1, 9 Zalcman G....Olofsson B. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 391 HGNC: 672 AceView: RHOG Ensembl:ENSG00000177105 euGenes: HUgn391
    ECgene: RHOG Kegg: 391 H-InvDB: RHOG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHOG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHOG gene:
    Search GeneIP for patents involving RHOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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