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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOG Gene

protein-coding   GIFtS: 63
GCID: GC11M003848

Ras Homolog Family Member G

(Previous names: ras homolog gene family, member G (rho G))
(Previous symbol: ARHG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Homolog Family Member G1 2
ARHG1 2 3 5
Ras Homolog Gene Family, Member G (Rho G)1 2
Rho-Related GTP-Binding Protein RhoG2

External Ids:    HGNC: 6721   Entrez Gene: 3912   Ensembl: ENSG000001771057   OMIM: 1795055   UniProtKB: P840953   

Export aliases for RHOG gene to outside databases

Previous GC identifers: GC11M003813 GC11M003804 GC11M003581


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOG Gene:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active
GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote
reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein
facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to
the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium
formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. (provided by
RefSeq, Aug 2011)

GeneCards Summary for RHOG Gene: 
RHOG (ras homolog family member G) is a protein-coding gene. Diseases associated with RHOG include shigellosis, and tangier disease, and among its related super-pathways are Signaling by GPCR and Sema4D in semaphorin signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095
Function: Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration
and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In
case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton
rearrangements and promotes bacterial entry

summary for RHOG Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for RHOG (RhoG) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOG gene promoter:
         SRF   MAZR   AP-1   SRF (504 AA)   ATF-2   FOXJ2 (long isoform)   FOXJ2   c-Jun   NF-kappaB1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RHOG promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5-p15.4

RHOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOG gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003848:  view genomic region     (about GC identifiers)

Start:
3,848,208 bp from pter      End:
3,862,213 bp from pter
Size:
14,006 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoG precursor  
Size: 191 amino acids; 21309 Da
Subunit: Interacts with ARHGEF26. Interacts with ARHGEF16
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: P35238 Q8NI04

Explore the universe of human proteins at neXtProt for RHOG: NX_P84095

Explore proteomics data for RHOG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P84095

  • RHOG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOG Protein Expression
    REFSEQ proteins: NP_001656.2  
    ENSEMBL proteins: 
     ENSP00000339467   ENSP00000380176   ENSP00000380175   ENSP00000436932  
    Reactome Protein details: P84095
    Human Recombinant Protein Products for RHOG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for RHOG
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for RHOG
    Novus Biologicals RHOG Proteins
    Novus Biologicals RHOG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RHOG
    Cloud-Clone Corp. Proteins for RHOG 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    RHOG for ontologies           About GeneDecksing



    RHOG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RHOG
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    Novus Biologicals RHOG Antibodies
    Abcam antibodies for RHOG
    Cloud-Clone Corp. Antibodies for RHOG 
    Search ThermoFisher Antibodies for RHOG
    LSBio Antibodies in human, mouse, rat for RHOG 

    Assay Products for RHOG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RHOG
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    GenScript Custom Assay Services for RHOG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOG 
    Cloud-Clone Corp. CLIAs for RHOG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P84095

    ProtoNet protein and cluster: P84095

    UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOG_HUMAN, P84095
    Function: Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration
    and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In
    case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton
    rearrangements and promotes bacterial entry

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA12376551
    GO:0005515protein binding IPI12879077
    GO:0005525GTP binding IEA--
         
    RHOG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RHOG:
     Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhog):
     cellular  hematopoietic system  immune system  nervous system 

    RHOG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rhogtm1Tnr for RHOG

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOG:
    hsa-let-7b (MIRT001598)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOG
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOG (see all 20):
    hsa-miR-3910 hsa-miR-199b-3p hsa-miR-2909 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-331-3p hsa-miR-3150a-3p hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmidRHOG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOG

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RHOG
    Sirion Biotech Customized adenovirus for overexpression of RHOG

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RHOG (see all 7)
    OriGene ORF clones in mouse, rat for RHOG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOG (NM_001665)
    Sino Biological Human cDNA Clone for RHOG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOG
    Sirion Biotech Customized lentivirus for stable overexpression of RHOG 
                         Customized lentivirus expression plasmids for stable overexpression of RHOG 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RHOG
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHOG About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Sema4D in semaphorin signaling
    Sema4D in semaphorin signaling0.89
    Semaphorin interactions0.41
    Sema4D induced cell migration and growth-cone collapse0.89
    3Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    4Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    5Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for RHOG
        BDNF signaling pathway
    Neurotrophic factor-mediated Trk receptor signaling


    5/14        Reactome Pathways for RHOG (see all 14)
        GPCR downstream signaling
    Hemostasis
    Signaling by Rho GTPases
    Developmental Biology
    G alpha (12/13) signalling events


    3         Kegg Pathways  (Kegg details for RHOG):
        Bacterial invasion of epithelial cells
    Shigellosis
    Salmonella infection


    RHOG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for RHOG (P840951, 3 ENSP000003394674) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELMO1Q925561, 3, ENSP000003121854EBI-446579,EBI-346417 I2D: score=4 STRING: ENSP00000312185
    MAP3K11Q165843, ENSP000003095974I2D: score=3 STRING: ENSP00000309597
    ARHGDIGQ998193, ENSP000002194094I2D: score=2 STRING: ENSP00000219409
    VAV1P154983, ENSP000003022694I2D: score=2 STRING: ENSP00000302269
    VAV2P527353, ENSP000003609164I2D: score=2 STRING: ENSP00000360916
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS1620121
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--

    RHOG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RHOG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    2 Novoseek inferred chemical compound relationships for RHOG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 65.7 1 8939998 (1)
    gtp 55.1 2 8939998 (2)

    Search CenterWatch for drugs/clinical trials and news about RHOG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHOG gene: 
    NM_001665.3  

    Unigene Cluster for RHOG:

    Ras homolog family member G
    Hs.501728  [show with all ESTs]
    Unigene Representative Sequence: BM912141
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351018(uc001lyu.2) ENST00000396979 ENST00000396978 ENST00000533217

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOG
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOG (see all 20):
    hsa-miR-3910 hsa-miR-199b-3p hsa-miR-2909 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-331-3p hsa-miR-3150a-3p hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmidRHOG 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RHOG (NM_001665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOG
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOG

    Additional mRNA sequence: 

    AF498974.1 AY563952.1 BC104177.2 BC104178.2 BT019872.1 CR450335.1 CR542105.1 L11317.1 
    X61587.1 

    7 DOTS entries:

    DT.95308177  DT.100761948  DT.316427  DT.100652041  DT.92429039  DT.86851986  DT.95149185 

    24/289 AceView cDNA sequences (see all 289):

    CF127555 BM553386 L11317 AW027360 AA811659 CR625567 AU104863 CR610572 
    BX448424 BU784032 CR611274 BX448423 BQ942142 AY563952 BM769032 CR595510 
    AA613507 BM543859 CR450335 AA010646 BG119083 CR616579 AI288206 R76313 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOG expression in normal human tissues (normalized intensities)      RHOG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTGGGGA
    RHOG Expression
    About this image


    RHOG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)
             bone marrow   
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Bone (Muscoskeletal System)
             bone marrow   
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter

    See RHOG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOG

    SOURCE GeneReport for Unigene cluster: Hs.501728
        SABiosciences Custom PCR Arrays for RHOG
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RHOG gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhog1 , 5 ras homolog gene family, member G1, 5 90.92(n)1
    100(a)1
      7 (54.71 cM)5
    562121  NM_019566.31  NP_062512.11 
     1022391235 
    chicken
    (Gallus gallus)
    Aves LOC1008595991 rho-related GTP-binding protein RhoG-like 80.45(n)
    84.82(a)
      100859599  XM_003640618.1  XP_003640666.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOG6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    GL343900.1(132169-132744)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689332 hypothetical protein MGC68933 80.94(n)    BC059300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk30f012 wufk30f01 77.73(n)   336933  BC044508.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mtl6
    Mig-2-like
    64(a)
    1 ↔ 1
    3R(23462134-23465593)
    worm
    (Caenorhabditis elegans)
    Secernentea mig-26
    Protein MIG-2
    58(a)
    1 ↔ 1
    X(11548608-11550700)


    ENSEMBL Gene Tree for RHOG (if available)
    TreeFam Gene Tree for RHOG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOG gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    18/42 SIMAP similar genes for RHOG using alignment to 1 protein entry:     RHOG_HUMAN(see all similar genes):
    ARHG    RAC3    CDC42    RAC1    RAC2    RHOB
    RHOQ    RHOV    RHOA    RHOJ    RHOC    RHOF
    RHOU    RHOD    RHOH    ARHE    RND3    RND2

    RHOG for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RHOG
    PGOHUM00000247454 PGOHUM00000241380 PGOHUM00000241834


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/378 SNPs in RHOG are shown (see all 378)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1879402381,2
    --3787226(+) AAATGC/TGGTGT 1 -- int10--------
    rs1488099261,2
    --3787292(+) TAGCAC/TGTGTA 1 -- int10--------
    rs1393199681,2
    --3848162(+) CCTAGC/TCCATG 1 -- int10--------
    rs122762711,2
    F,H--3848175(+) CACCCG/ACTAAT 1 -- int16Minor allele frequency- A:0.00NS EA CSA 420
    rs1841043211,2
    --3848243(+) ATGGGA/GGTAGG 1 -- ut310--------
    rs171738791,2
    C,F,H--3848294(+) TGCGTA/GAGGCC 1 -- ut3110Minor allele frequency- G:0.01NA NS EA WA 684
    rs10493881,2
    C,F,A,H--3848373(-) ATGCTC/GTCTCC 1 -- ut31 ese3 trp314Minor allele frequency- G:0.09MN NS EA NA WA CSA 847
    rs1495871431,2
    --3848475(+) ACTGTA/GTGGAA 1 -- ut310--------
    rs122899891,2
    C,H--3848492(+) ATGAAC/ATGGTC 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs1119840621,2
    C--3848731(+) CGGACA/GAGGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RHOG (3848208 - 3862213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RHOG:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv896894CNV Loss21882294


    Human Gene Mutation Database (HGMD): RHOG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOG
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179505    OMIM disorders: --

    6 diseases for RHOG:    About MalaCards
    shigellosis    tangier disease    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    endotheliitis    thyroiditis


    RHOG for disorders           About GeneDecksing

    Genetic Association Database (GAD): RHOG
    Human Genome Epidemiology (HuGE) Navigator: RHOG (5 documents)

    Export disorders for RHOG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOG gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with RHOG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ephexin4 and EphA2 mediate cell migration through a R hoG-dependent mechanism. (PubMed id 20679435)1, 2 Hiramoto-Yamaki N....Katoh H. (2010)
    2. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    3. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    4. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. (PubMed id 17875742)1, 2 van Buul J.D....Burridge K. (2007)
    5. Oncogene ect2 is related to regulators of small GTP-binding proteins. (PubMed id 8464478)1, 2 Miki T.... Fleming T.P. (1993)
    6. Localization of ARHG, a member of the RAS homolog gene family, to 11p15.5-11p15.4 by fluorescence in situ hybridization. (PubMed id 8325658)1, 3 Taviaux S.A....Demaille J.G. (1993)
    7. Growth-regulated expression of rhoG, a new member of the ras homolog gene family. (PubMed id 1620121)1, 2 Vincent S.... Fort P. (1992)
    8. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. (PubMed id 15199069)1, 9 Skowronek K.R....Nassar N. (2004)
    9. Structure of the human ARHG locus encoding the Rho/Rac-like RhoG GTPase. (PubMed id 9177787)1, 9 Le Gallic L. and Fort P. (1997)
    10. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. (PubMed id 8939998)1, 9 Zalcman G....Olofsson B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 391 HGNC: 672 AceView: RHOG Ensembl:ENSG00000177105 euGenes: HUgn391
    ECgene: RHOG Kegg: 391 H-InvDB: RHOG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHOG gene:
    Search GeneIP for patents involving RHOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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