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Aliases for RHOG Gene

Aliases for RHOG Gene

  • Ras Homolog Family Member G 2 3
  • ARHG 3 4 6
  • Ras Homolog Gene Family, Member G (Rho G) 2 3
  • Rho-Related GTP-Binding Protein RhoG 3

External Ids for RHOG Gene

Previous HGNC Symbols for RHOG Gene

  • ARHG

Previous GeneCards Identifiers for RHOG Gene

  • GC11M003813
  • GC11M003804
  • GC11M003581

Summaries for RHOG Gene

Entrez Gene Summary for RHOG Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

GeneCards Summary for RHOG Gene

RHOG (Ras Homolog Family Member G) is a Protein Coding gene. Diseases associated with RHOG include shigellosis. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOG Gene

  • Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

Tocris Summary for RHOG Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families; Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS. They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand, thus promoting malignant progression.

Gene Wiki entry for RHOG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOG Gene

Genomics for RHOG Gene

Regulatory Elements for RHOG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RHOG Gene

Start:
3,826,978 bp from pter
End:
3,840,983 bp from pter
Size:
14,006 bases
Orientation:
Minus strand

Genomic View for RHOG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOG Gene

Proteins for RHOG Gene

  • Protein details for RHOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84095-RHOG_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoG
    Protein Accession:
    P84095
    Secondary Accessions:
    • P35238
    • Q8NI04

    Protein attributes for RHOG Gene

    Size:
    191 amino acids
    Molecular mass:
    21309 Da
    Quaternary structure:
    • Interacts with ARHGEF26. Interacts with ARHGEF16.

neXtProt entry for RHOG Gene

Proteomics data for RHOG Gene at MOPED

Post-translational modifications for RHOG Gene

  • Ubiquitination at Lys130, Lys147, and Lys183
  • Modification sites at PhosphoSitePlus

Other Protein References for RHOG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOG Gene

Domains for RHOG Gene

Protein Domains for RHOG Gene

Suggested Antigen Peptide Sequences for RHOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P84095

UniProtKB/Swiss-Prot:

RHOG_HUMAN :
  • P84095
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOG: view

No data available for Gene Families for RHOG Gene

Function for RHOG Gene

Molecular function for RHOG Gene

UniProtKB/Swiss-Prot Function: Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

Gene Ontology (GO) - Molecular Function for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 12376551
GO:0005515 protein binding IPI 12879077
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOG: view

Phenotypes for RHOG Gene

genes like me logo Genes that share phenotypes with RHOG: view

Animal Models for RHOG Gene

MGI Knock Outs for RHOG:

Animal Model Products

CRISPR Products

miRNA for RHOG Gene

miRTarBase miRNAs that target RHOG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RHOG Gene

Localization for RHOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOG Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOG Gene COMPARTMENTS Subcellular localization image for RHOG gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with RHOG: view

Pathways for RHOG Gene

genes like me logo Genes that share pathways with RHOG: view

Gene Ontology (GO) - Biological Process for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOG: view

Compounds for RHOG Gene

(5) Tocris Compounds for RHOG Gene

Compound Action Cas Number
CASIN Cdc42 GTPase inhibitor [425399-05-9]
EHT 1864 Potent inhibitor of Rac family GTPases [754240-09-0]
NSC 23766 Selective inhibitor of Rac1-GEF interaction; antioncogenic [1177865-17-6]
SecinH3 Sec7-specific GEF inhibitor (cytohesins) [853625-60-2]
ZCL 278 Cdc42 inhibitor [587841-73-4]

(2) Novoseek inferred chemical compound relationships for RHOG Gene

Compound -log(P) Hits PubMed IDs
gdp 65.7 1
gtp 55.1 2
genes like me logo Genes that share compounds with RHOG: view

Transcripts for RHOG Gene

mRNA/cDNA for RHOG Gene

Unigene Clusters for RHOG Gene

Ras homolog family member G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RHOG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOG Gene

No ASD Table

Relevant External Links for RHOG Gene

GeneLoc Exon Structure for
RHOG
ECgene alternative splicing isoforms for
RHOG

Expression for RHOG Gene

mRNA expression in normal human tissues for RHOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOG Gene

This gene is overexpressed in Whole Blood (24.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOG Gene

SOURCE GeneReport for Unigene cluster for RHOG Gene Hs.501728

genes like me logo Genes that share expressions with RHOG: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RHOG Gene

Orthologs for RHOG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOG 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOG 35
  • 93.02 (n)
  • 98.95 (a)
RHOG 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOG 35
  • 93.54 (n)
  • 99.48 (a)
RHOG 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhog 35
  • 90.92 (n)
  • 100 (a)
Rhog 16
Rhog 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOG 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOG 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhog 35
  • 91.8 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves LOC100859599 35
  • 80.45 (n)
  • 84.82 (a)
RHOG 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOG 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68933 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489878 35
  • 75.04 (n)
  • 83.25 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5267 35
zebrafish
(Danio rerio)
Actinopterygii rhoga 36
  • 73 (a)
OneToMany
rhogb 35
  • 72.6 (n)
  • 80.1 (a)
rhogb 36
  • 80 (a)
OneToMany
wufk30f01 35
fruit fly
(Drosophila melanogaster)
Insecta Rac1 36
  • 68 (a)
ManyToMany
Rac2 36
  • 67 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ced-10 36
  • 67 (a)
ManyToMany
Species with no ortholog for RHOG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOG Gene

ENSEMBL:
Gene Tree for RHOG (if available)
TreeFam:
Gene Tree for RHOG (if available)

Paralogs for RHOG Gene

Paralogs for RHOG Gene

Pseudogenes.org Pseudogenes for RHOG Gene

genes like me logo Genes that share paralogs with RHOG: view

Variants for RHOG Gene

Sequence variations from dbSNP and Humsavar for RHOG Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1049386 -- 3,827,200(-) GGGCT(C/T)TCAGC utr-variant-3-prime
rs1049388 -- 3,827,143(-) ATGCT(C/G)TCTCC utr-variant-3-prime
rs1049391 -- 3,827,030(-) TGCTT(C/T)TGGGG utr-variant-3-prime
rs4353269 -- 3,841,071(+) ACGGC(C/G)CGCCC upstream-variant-2KB
rs4406820 -- 3,841,303(+) CTGGT(C/G)CCTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RHOG Gene

Variant ID Type Subtype PubMed ID
nsv896894 CNV Loss 21882294

Relevant External Links for RHOG Gene

HapMap Linkage Disequilibrium report
RHOG
Human Gene Mutation Database (HGMD)
RHOG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOG Gene

Disorders for RHOG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RHOG Gene including...

Search for RHOG Gene in MalaCards »

Relevant External Links for RHOG

Genetic Association Database (GAD)
RHOG
Human Genome Epidemiology (HuGE) Navigator
RHOG
genes like me logo Genes that share disorders with RHOG: view

No data available for UniProtKB/Swiss-Prot for RHOG Gene

Publications for RHOG Gene

  1. Growth-regulated expression of rhoG, a new member of the ras homolog gene family. (PMID: 1620121) Vincent S. … Fort P. (Mol. Cell. Biol. 1992) 3 4
  2. Localization of ARHG, a member of the RAS homolog gene family, to 11p15.5-11p15.4 by fluorescence in situ hybridization. (PMID: 8325658) Taviaux S.A. … Demaille J.G. (Genomics 1993) 2 3
  3. Oncogene ect2 is related to regulators of small GTP-binding proteins. (PMID: 8464478) Miki T. … Fleming T.P. (Nature 1993) 3 4
  4. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I. … Robledo M. (PLoS Genet. 2009) 3 48
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 48

Products for RHOG Gene

Sources for RHOG Gene

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