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Aliases & Descriptions for RHOG
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ARHG 2, 3 | | MGC125835 1, 2 | | MGC125836 1, 2 | | OTTHUMP00000014180 2 | | OTTHUMP00000014181 2 | | RhoG 1 |
| | | Descriptions |
|---|
| ras homolog gene family, member G 2 | | ras homolog gene family, member G (rho G) 2 |
|
| | Search outside databases for aliases for RHOG genePrevious GC identifer: GC11M003813 |
Summaries for RHOG(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RHOG: ARHG is a member of the RAS superfamily of genes, which encode GTP-binding proteins that act in the pathway of signal transduction and play a key role in the regulation of cellular functions.[supplied by OMIM] UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095Function: Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and SGEF, which induces cytoskeleton rearrangements and promotes bacterial entryGene Wiki entry for RHOG (RhoG) |
Genomic Location for RHOG
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RHOG gene 
Entrez Gene cytogenetic band: 11p15.5-p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5-p15.4RHOG Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M003804:
(about GC identifiers)
Start:
|
3,804,784 bp from pter |
End:
|
3,818,789 bp from pter |
Size:
|
14,006 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_009237.17
| Proteins for RHOG
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095 (See
protein sequence)Recommended Name: Rho-related GTP-binding protein RhoG precursor Size: 191 amino acids; 21309 Da
Subunit: Interacts with SGEF
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: P35238 Q8NI04REFSEQ proteins: NP_001656.2
ENSEMBL proteins: ENSP00000380175 ENSP00000380176 ENSP00000339467
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RHOG: Assays for RHOG: | Protein
Domains/ Families for RHOG(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P84095
ProtoNet protein and cluster: P84095 UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095Similarity: Belongs to the small GTPase superfamily. Rho family | Gene Function for RHOG
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001665
Applied Biosystems Silencer® siRNAs for RHOG
Sigma-Aldrich siRNA and siRNA Panels for RHOG  Sigma-Aldrich shRNA for RHOG  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001665                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001665                                  untagged cDNA clone in CMV expression vector: NM_001665 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001665
UniProtKB/Swiss-Prot: RHOG_HUMAN, P84095Function: Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rhog):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RHOG
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for RHOG (Your Favorite Gene powered by Ingenuity) (see all 11
) 
Gene Network CentralTM Interacting Genes and Proteins Network for RHOG 
5/136 Interacting proteins for RHOG (ENSP000003394673 P840951) via UniProtKB, MINT, and/or STRING (see all 136
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for RHOG(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RHOG |
Compounds for RHOG available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Anti-RacGAP | Antibody recognizing RacGAP | | About this table
2 Novoseek chemical compound relationships for RHOG gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gdp |
67.45 |
1 |
8939998 (1) |
| gtp |
56.88 |
2 |
8939998 (2) |
About this table
|
Transcripts for RHOG(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001665
Sigma-Aldrich siRNA and siRNA Panels for RHOG  Sigma-Aldrich shRNA for RHOG  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001665 REFSEQ mRNAs for RHOG gene: NM_001665.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001665               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001665                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001665                                  untagged cDNA clone in CMV expression vector: NM_001665  Additional cDNA sequence: AF498974.1 AY563952.1 BC104177.2 BC104178.2 BT019872.1 CR450335.1 CR542105.1 CR595510.1 CR610572.1 CR611274.1 CR611277.1 CR612317.1 CR614056.1 CR616579.1 CR625234.1 CR625567.1 L11317.1 X61587.1 7 DOTS entries: DT.95308177 DT.100761948 DT.316427 DT.100652041 DT.92429039 DT.95149185 DT.86851986 24/289 AceView cDNA sequences (see all 289
):BQ673820 BU617808 AI288206 CK902612 BM543859 BM912761 BU632944 CD674008 AU104863 CR595510 BI753210 BM553386 BM851558 BF128629 CR611274 CR610572 BP353272 R76313 AA613507 BI754469 AA010646 BX448423 CR611277 BQ688619
highest scoring ESTs for RHOG:X61587 AU099257 AW193418 BE241849 BE408253 BE409267 BE728903 BE736236 BE872106 BF237664 Unigene Cluster for RHOG: Ras homolog gene family, member G (rho G) Hs.501728 [show with all ESTs]Unigene Representative Sequence: BM912141
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000396978
ENST00000396979
ENST00000351018
|
Expression for RHOG
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RHOG expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RHOG
1 / 2 / 3 3 probe-sets matching RHOG gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTTCTGGGGA
SOURCE GeneReport for Unigene cluster: Hs.501728
Expression variation in blood from EXPOLDB for RHOG |
Orthologs for RHOG
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RHOG gene from 5/7 species (see all 7
)
About this table Species with no ortholog for RHOG
ENSEMBL Gene Tree for RHOG | Paralogs for RHOG(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RHOG gene
- RAC12 RAC22 RAC32
|
SNPs/Variants for RHOG(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RHOG (up to first 250kb)
|
Disorders & Mutations for RHOG
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 179505
|
Medical News for RHOG(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RHOG (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/40 PubMed articles for RHOG gene (see all 40
):- RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. (PubMed id 17875742)3, 4 van Buul J.D....Burridge K. (2007)
- Oncogene ect2 is related to regulators of small GTP-binding proteins. (PubMed id 8464478)3, 4 Miki T.... Fleming T.P. (1993)
- Localization of ARHG, a member of the RAS homolog gene family, to 11p15.5-11p15.4 by fluorescence in situ hybridization. (PubMed id 8325658)2, 3 Taviaux S.A....Demaille J.G. (1993)
- Growth-regulated expression of rhoG, a new member of the ras homolog gene family. (PubMed id 1620121)3, 4 Vincent S.... Fort P. (1992)
- The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. (PubMed id 15199069)1, 3 Skowronek K.R....Nassar N. (2004)
- Structure of the human ARHG locus encoding the Rho/Rac-like RhoG GTPase. (PubMed id 9177787)1, 3 Le Gallic L. and Fort P. (1997)
- RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. (PubMed id 8939998)1, 3 Zalcman G....Olofsson B. (1996)
- RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism. (PubMed id 17570359)3 Yamaki N....Katoh H. (2007)
- Dock4 is regulated by RhoG and promotes Rac-dependent cell migration. (PubMed id 17027967)3 Hiramoto K....Katoh H. (2006)
- Involvement of the Rho/Rac family member RhoG in caveolar endocytosis. (PubMed id 16568096)3 Prieto-Sanchez R.M....Bustelo X.R. (2006)
|
Search for RHOG
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RHOG
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RHOG
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RHOG(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RHOG(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RHOG:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (RHOG) | | Antibodies (RHOG) |
| | | Tocris compounds for RHOG |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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