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Aliases for RHOF Gene

Aliases for RHOF Gene

  • Ras Homolog Family Member F (In Filopodia) 2 3
  • Ras Homolog Gene Family, Member F (In Filopodia) 2 3
  • Rho Family GTPase Rif 3 4
  • Rho In Filopodia 3 4
  • ARHF 3 4
  • RIF 3 4
  • Rho-Related GTP-Binding Protein RhoF 3

External Ids for RHOF Gene

Previous Symbols for RHOF Gene

  • ARHF

Summaries for RHOF Gene

GeneCards Summary for RHOF Gene

RHOF (Ras Homolog Family Member F (In Filopodia)) is a Protein Coding gene. Diseases associated with RHOF include malaria. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOF Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOF Gene

Genomics for RHOF Gene

Genomic Location for RHOF Gene

Start:
121,777,754 bp from pter
End:
121,803,403 bp from pter
Size:
25,650 bases
Orientation:
Minus strand

Genomic View for RHOF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOF Gene

Regulatory Elements for RHOF Gene

Proteins for RHOF Gene

  • Protein details for RHOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH0-RHOF_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoF
    Protein Accession:
    Q9HBH0
    Secondary Accessions:
    • Q8WVB1
    • Q9NXH6

    Protein attributes for RHOF Gene

    Size:
    211 amino acids
    Molecular mass:
    23625 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RHOF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOF Gene

Proteomics data for RHOF Gene at MOPED

Post-translational modifications for RHOF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOF Gene

No data available for DME Specific Peptides for RHOF Gene

Domains for RHOF Gene

UniProtKB/Swiss-Prot:

RHOF_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • Q9HBH0
genes like me logo Genes that share domains with RHOF: view

No data available for Gene Families for RHOF Gene

Function for RHOF Gene

Molecular function for RHOF Gene

UniProtKB/Swiss-Prot Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology

Gene Ontology (GO) - Molecular Function for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 11084341
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOF: view

Phenotypes for RHOF Gene

genes like me logo Genes that share phenotypes with RHOF: view

Animal Models for RHOF Gene

MGI Knock Outs for RHOF:

miRNA for RHOF Gene

miRTarBase miRNAs that target RHOF

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RHOF Gene

Localization for RHOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOF Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOF Gene COMPARTMENTS Subcellular localization image for RHOF gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton NAS 11084341
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RHOF: view

Pathways for RHOF Gene

genes like me logo Genes that share pathways with RHOF: view

Pathways by source for RHOF Gene

Gene Ontology (GO) - Biological Process for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007015 actin filament organization IDA 11084341
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RHOF: view

Compounds for RHOF Gene

(1) HMDB Compounds for RHOF Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RHOF: view

Transcripts for RHOF Gene

mRNA/cDNA for RHOF Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOF Gene

Ras homolog family member F (in filopodia):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOF Gene

No ASD Table

Relevant External Links for RHOF Gene

GeneLoc Exon Structure for
RHOF
ECgene alternative splicing isoforms for
RHOF

Expression for RHOF Gene

mRNA expression in normal human tissues for RHOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOF Gene

This gene is overexpressed in Whole Blood (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOF Gene

SOURCE GeneReport for Unigene cluster for RHOF Gene Hs.644504

genes like me logo Genes that share expressions with RHOF: view

Orthologs for RHOF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOF 36
  • 99.37 (n)
  • 99.05 (a)
RHOF 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOF 36
  • 93.2 (n)
  • 97.96 (a)
RHOF 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOF 36
  • 90.94 (n)
  • 96.41 (a)
RHOF 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhof 36
  • 87.36 (n)
  • 92.89 (a)
Rhof 16
Rhof 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOF 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOF 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhof 36
  • 87.99 (n)
  • 93.36 (a)
chicken
(Gallus gallus)
Aves RHOF 36
  • 69.54 (n)
  • 74.16 (a)
RHOF 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOF 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16583 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rhof 36
  • 66.5 (n)
  • 72.45 (a)
Str.8197 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10985 36
zebrafish
(Danio rerio)
Actinopterygii rhof 36
  • 62.69 (n)
  • 65.67 (a)
rhof 37
  • 64 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 37
  • 48 (a)
OneToMany
Species with no ortholog for RHOF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOF Gene

ENSEMBL:
Gene Tree for RHOF (if available)
TreeFam:
Gene Tree for RHOF (if available)

Paralogs for RHOF Gene

Paralogs for RHOF Gene

Pseudogenes.org Pseudogenes for RHOF Gene

genes like me logo Genes that share paralogs with RHOF: view

Variants for RHOF Gene

Sequence variations from dbSNP and Humsavar for RHOF Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs895950 -- 121,794,133(+) AGCGG(C/T)GTGGC upstream-variant-2KB
rs921286 -- 121,789,785(+) AGCAA(A/C)TCCTA intron-variant
rs1168667 -- 121,788,623(+) TGGGC(A/G)GGACT intron-variant
rs1168668 -- 121,789,545(+) AGCTG(C/G)GGCGT intron-variant
rs1168669 -- 121,790,788(+) GGGGG(C/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOF Gene

Variant ID Type Subtype PubMed ID
nsv899566 CNV Loss 21882294
nsv899567 CNV Gain 21882294
esv2670889 CNV Deletion 23128226
esv2746493 CNV Deletion 23290073
esv2746494 CNV Deletion 23290073
esv2746495 CNV Deletion 23290073

Relevant External Links for RHOF Gene

HapMap Linkage Disequilibrium report
RHOF

Disorders for RHOF Gene

(1) MalaCards Diseases for RHOF Gene

Search for RHOF Gene in MalaCards »

(1) Novoseek inferred disease relationships for RHOF Gene

Disease -log(P) Hits PubMed IDs
malaria 62.7 3

Relevant External Links for RHOF

Genetic Association Database (GAD)
RHOF
genes like me logo Genes that share disorders with RHOF: view

No data available for UniProtKB/Swiss-Prot for RHOF Gene

Publications for RHOF Gene

  1. The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements. (PMID: 11084341) Ellis S. … Mellor H. (Curr. Biol. 2000) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF. (PMID: 18663754) Carbone A. … Amerio P. (Genes Chromosomes Cancer 2008) 3

Products for RHOF Gene

  • Addgene plasmids for RHOF

Sources for RHOF Gene

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