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Aliases for RHOF Gene

Aliases for RHOF Gene

  • Ras Homolog Family Member F (In Filopodia) 2 3 5
  • Ras Homolog Gene Family, Member F (In Filopodia) 2 3
  • Rho Family GTPase Rif 3 4
  • Rho In Filopodia 3 4
  • ARHF 3 4
  • RIF 3 4

External Ids for RHOF Gene

Previous HGNC Symbols for RHOF Gene

  • ARHF

Previous GeneCards Identifiers for RHOF Gene

  • GC12M120615
  • GC12M120678
  • GC12M120700
  • GC12M122215
  • GC12M119227

Summaries for RHOF Gene

GeneCards Summary for RHOF Gene

RHOF (Ras Homolog Family Member F (In Filopodia)) is a Protein Coding gene. Diseases associated with RHOF include Malaria. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOF Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOF Gene

Genomics for RHOF Gene

Regulatory Elements for RHOF Gene

Enhancers for RHOF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RHOF on UCSC Golden Path with GeneCards custom track

Promoters for RHOF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHOF on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOF Gene

Chromosome:
12
Start:
121,777,754 bp from pter
End:
121,803,403 bp from pter
Size:
25,650 bases
Orientation:
Minus strand

Genomic View for RHOF Gene

Genes around RHOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOF Gene

Proteins for RHOF Gene

  • Protein details for RHOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH0-RHOF_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoF
    Protein Accession:
    Q9HBH0
    Secondary Accessions:
    • Q8WVB1
    • Q9NXH6

    Protein attributes for RHOF Gene

    Size:
    211 amino acids
    Molecular mass:
    23625 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RHOF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOF Gene

Proteomics data for RHOF Gene at MOPED

Post-translational modifications for RHOF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOF Gene

No data available for DME Specific Peptides for RHOF Gene

Domains & Families for RHOF Gene

Gene Families for RHOF Gene

Suggested Antigen Peptide Sequences for RHOF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBH0

UniProtKB/Swiss-Prot:

RHOF_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOF: view

Function for RHOF Gene

Molecular function for RHOF Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
genes like me logo Genes that share phenotypes with RHOF: view

Animal Models for RHOF Gene

MGI Knock Outs for RHOF:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOF Gene

Localization for RHOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOF Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOF Gene COMPARTMENTS Subcellular localization image for RHOF gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
plasma membrane 4
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton NAS 11084341
genes like me logo Genes that share ontologies with RHOF: view

Pathways & Interactions for RHOF Gene

genes like me logo Genes that share pathways with RHOF: view

Pathways by source for RHOF Gene

Gene Ontology (GO) - Biological Process for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IDA 11084341
GO:0007165 signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOF: view

No data available for SIGNOR curated interactions for RHOF Gene

Drugs & Compounds for RHOF Gene

(1) Drugs for RHOF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHOF: view

Transcripts for RHOF Gene

mRNA/cDNA for RHOF Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOF Gene

Ras homolog family member F (in filopodia):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOF Gene

No ASD Table

Relevant External Links for RHOF Gene

GeneLoc Exon Structure for
RHOF
ECgene alternative splicing isoforms for
RHOF

Expression for RHOF Gene

mRNA expression in normal human tissues for RHOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOF Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for RHOF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.1), Platelet (7.8), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOF Gene



SOURCE GeneReport for Unigene cluster for RHOF Gene Hs.644504

genes like me logo Genes that share expression patterns with RHOF: view

Protein tissue co-expression partners for RHOF Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RHOF Gene

Orthologs for RHOF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RHOF 35
  • 93.2 (n)
  • 97.96 (a)
RHOF 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOF 35
  • 90.94 (n)
  • 96.41 (a)
RHOF 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhof 35
  • 87.36 (n)
  • 92.89 (a)
Rhof 16
Rhof 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RHOF 35
  • 99.37 (n)
  • 99.05 (a)
RHOF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhof 35
  • 87.99 (n)
  • 93.36 (a)
oppossum
(Monodelphis domestica)
Mammalia RHOF 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOF 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOF 35
  • 69.54 (n)
  • 74.16 (a)
RHOF 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOF 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhof 35
  • 66.5 (n)
  • 72.45 (a)
Str.8197 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16583 35
zebrafish
(Danio rerio)
Actinopterygii rhof 35
  • 62.69 (n)
  • 65.67 (a)
rhof 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10985 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 36
  • 48 (a)
OneToMany
Species with no ortholog for RHOF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOF Gene

ENSEMBL:
Gene Tree for RHOF (if available)
TreeFam:
Gene Tree for RHOF (if available)

Paralogs for RHOF Gene

Pseudogenes.org Pseudogenes for RHOF Gene

genes like me logo Genes that share paralogs with RHOF: view

Variants for RHOF Gene

Sequence variations from dbSNP and Humsavar for RHOF Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7300684 -- 121,786,911(+) CAGGC(A/G)CGTGT intron-variant
rs7308123 -- 121,787,319(+) CTGGG(C/T)GGGGA intron-variant
rs7308348 -- 121,787,514(+) agttt(C/T)ctcat intron-variant
rs12832268 -- 121,784,855(+) ATGGC(A/C)GGAGT intron-variant
rs12832320 -- 121,784,889(+) accca(C/T)aaggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOF Gene

Variant ID Type Subtype PubMed ID
nsv899566 CNV Loss 21882294
nsv899567 CNV Gain 21882294
esv2670889 CNV Deletion 23128226
esv2746493 CNV Deletion 23290073
esv2746494 CNV Deletion 23290073
esv2746495 CNV Deletion 23290073

Variation tolerance for RHOF Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RHOF Gene

Disorders for RHOF Gene

MalaCards: The human disease database

(1) MalaCards diseases for RHOF Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
malaria
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search RHOF in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHOF

Genetic Association Database (GAD)
RHOF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOF
genes like me logo Genes that share disorders with RHOF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOF Gene

Publications for RHOF Gene

  1. The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements. (PMID: 11084341) Ellis S. … Mellor H. (Curr. Biol. 2000) 2 3 4 23 67
  2. The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction. (PMID: 25668492) Fan L. … Mellor H. (Neurosci. Lett. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Nef interaction with actin compromises human podocyte actin cytoskeletal integrity. (PMID: 22721673) Tan R. … Singhal P.C. (Exp. Mol. Pathol. 2013) 3

Products for RHOF Gene

Sources for RHOF Gene

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