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Aliases for RHOF Gene

Aliases for RHOF Gene

  • Ras Homolog Family Member F, Filopodia Associated 2 3 5
  • Rho In Filopodia 2 3 4
  • Ras Homolog Gene Family, Member F (In Filopodia) 2 3
  • Ras Homolog Family Member F (In Filopodia) 2 3
  • Rho Family GTPase Rif 3 4
  • ARHF 3 4
  • RIF 3 4
  • Rho-Related GTP-Binding Protein RhoF 3

External Ids for RHOF Gene

Previous HGNC Symbols for RHOF Gene

  • ARHF

Previous GeneCards Identifiers for RHOF Gene

  • GC12M120615
  • GC12M120678
  • GC12M120700
  • GC12M122215
  • GC12M119227

Summaries for RHOF Gene

GeneCards Summary for RHOF Gene

RHOF (Ras Homolog Family Member F, Filopodia Associated) is a Protein Coding gene. Diseases associated with RHOF include Charcot-Marie-Tooth Disease, Axonal, Type 2L and Malaria. Among its related pathways are p75 NTR receptor-mediated signalling and Innate Immune System. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOD.

UniProtKB/Swiss-Prot for RHOF Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

Additional gene information for RHOF Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOF Gene

Genomics for RHOF Gene

Regulatory Elements for RHOF Gene

Enhancers for RHOF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H121765 1.1 Ensembl ENCODE 13.2 +36.4 36430 3.6 KLF17 FEZF1 TCF12 GLIS2 EGR1 ZNF366 ZSCAN5C RCOR1 FOS EGR2 TMEM120B RHOF SETD1B LINC01089 PSMD9 HPD ENSG00000256950 WDR66 ENSG00000272849
GH12H121769 0.8 ENCODE 13.3 +32.9 32910 2.7 ELF3 TBP PKNOX1 ARID4B THRB RARA TCF12 ZNF121 EGR2 CEBPB LINC01089 RHOF SETD1B ENSG00000272849 TMEM120B
GH12H121783 1.9 FANTOM5 ENCODE dbSUPER 3.9 +7.4 7411 24.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC MEF2D ZCCHC8 RSRC2 ENSG00000272849 PSMD9 SETD1B ANAPC5 KNTC1 LINC01089 HPD KDM2B
GH12H121559 1.3 FANTOM5 Ensembl ENCODE 4.8 +242.8 242811 1.2 TBL1XR1 BACH1 BMI1 EBF1 BATF RELA EED ATF7 RUNX3 IKZF2 LOC101928346 KDM2B P2RX4 CAMKK2 RHOF P2RX7 MIR7107
GH12H122265 1.2 ENCODE 4.2 -463.0 -462960 2.6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC RSRC2 ZCCHC8 ANAPC5 SETD1B ENSG00000272849 KNTC1 PSMD9 ENSG00000235423 ABCB9 C12orf65
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOF on UCSC Golden Path with GeneCards custom track

Promoters for RHOF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000270548 703 6201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Locations for RHOF Gene

Genomic Locations for RHOF Gene
chr12:121,777,754-121,803,403
(GRCh38/hg38)
Size:
25,650 bases
Orientation:
Minus strand
chr12:122,215,660-122,241,309
(GRCh37/hg19)

Genomic View for RHOF Gene

Genes around RHOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOF Gene

Proteins for RHOF Gene

  • Protein details for RHOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH0-RHOF_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoF
    Protein Accession:
    Q9HBH0
    Secondary Accessions:
    • Q8WVB1
    • Q9NXH6

    Protein attributes for RHOF Gene

    Size:
    211 amino acids
    Molecular mass:
    23625 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RHOF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOF Gene

Post-translational modifications for RHOF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOF Gene

No data available for DME Specific Peptides for RHOF Gene

Domains & Families for RHOF Gene

Gene Families for RHOF Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RHOF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBH0

UniProtKB/Swiss-Prot:

RHOF_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOF: view

Function for RHOF Gene

Molecular function for RHOF Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

Gene Ontology (GO) - Molecular Function for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,NAS 11084341
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOF: view
genes like me logo Genes that share phenotypes with RHOF: view

Animal Models for RHOF Gene

MGI Knock Outs for RHOF:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOF

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOF Gene

Localization for RHOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOF Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOF gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton NAS 11084341
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOF: view

Pathways & Interactions for RHOF Gene

genes like me logo Genes that share pathways with RHOF: view

Pathways by source for RHOF Gene

Gene Ontology (GO) - Biological Process for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IDA 11084341
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOF: view

No data available for SIGNOR curated interactions for RHOF Gene

Drugs & Compounds for RHOF Gene

(1) Drugs for RHOF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHOF: view

Transcripts for RHOF Gene

mRNA/cDNA for RHOF Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOF Gene

Ras homolog family member F (in filopodia):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOF

Alternative Splicing Database (ASD) splice patterns (SP) for RHOF Gene

No ASD Table

Relevant External Links for RHOF Gene

GeneLoc Exon Structure for
RHOF
ECgene alternative splicing isoforms for
RHOF

Expression for RHOF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOF Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for RHOF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.1), Platelet (7.8), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RHOF Gene



Protein tissue co-expression partners for RHOF Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOF Gene:

RHOF

SOURCE GeneReport for Unigene cluster for RHOF Gene:

Hs.644504

Evidence on tissue expression from TISSUES for RHOF Gene

  • Intestine(4.4)
  • Nervous system(3.7)
  • Lung(3.6)
  • Pancreas(2.7)
genes like me logo Genes that share expression patterns with RHOF: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOF Gene

Orthologs for RHOF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOF 33 34
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia RHOF 34 33
  • 93.2 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOF 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOF 33 34
  • 90.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RHOF 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhof 33
  • 87.99 (n)
mouse
(Mus musculus)
Mammalia Rhof 33 16 34
  • 87.36 (n)
chicken
(Gallus gallus)
Aves RHOF 33 34
  • 69.54 (n)
lizard
(Anolis carolinensis)
Reptilia RHOF 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhof 33
  • 66.5 (n)
Str.8197 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16583 33
zebrafish
(Danio rerio)
Actinopterygii rhof 33 34
  • 62.69 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10985 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 34
  • 48 (a)
OneToMany
Species where no ortholog for RHOF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOF Gene

ENSEMBL:
Gene Tree for RHOF (if available)
TreeFam:
Gene Tree for RHOF (if available)

Paralogs for RHOF Gene

Variants for RHOF Gene

Sequence variations from dbSNP and Humsavar for RHOF Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000148507 -- 121,795,445(+) AGGGT(A/G)GGTAA nc-transcript-variant, upstream-variant-2KB
rs1000233999 -- 121,782,059(+) CAACA(C/T)GAGTA intron-variant, utr-variant-3-prime
rs1000284728 -- 121,781,892(+) GATAC(C/T)TTAAT intron-variant, utr-variant-3-prime
rs1000363191 -- 121,793,293(+) AAAGT(C/T)CCAGC intron-variant, downstream-variant-500B
rs1000372640 -- 121,791,770(+) TGATG(C/G)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOF Gene

Variant ID Type Subtype PubMed ID
nsv1160065 CNV deletion 26073780
esv3892268 CNV loss 25118596
esv3630958 CNV loss 21293372
esv3549897 CNV deletion 23714750
esv2746495 CNV deletion 23290073
esv2746494 CNV deletion 23290073
esv2746493 CNV deletion 23290073
esv2670889 CNV deletion 23128226

Variation tolerance for RHOF Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOF Gene

Disorders for RHOF Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHOF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2l
  • charcot-marie-tooth disease, type 2i
malaria
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search RHOF in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHOF

Genetic Association Database (GAD)
RHOF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOF
genes like me logo Genes that share disorders with RHOF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOF Gene

Publications for RHOF Gene

  1. The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements. (PMID: 11084341) Ellis S … Mellor H (Current biology : CB 2000) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for RHOF Gene

  • Addgene plasmids for RHOF

Sources for RHOF Gene

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