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RHOF Gene

protein-coding   GIFtS: 54
GCID: GC12M122215

Ras Homolog Family Member F (In Filopodia)

(Previous names: ras homolog gene family, member F (in filopodia))
(Previous symbol: ARHF)
  See RHOF-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member F (In Filopodia)1 2     Rho In Filopodia2 3
ARHF1 2 3     RIF2 3
Ras Homolog Gene Family, Member F (In Filopodia)1 2     Rho-Related GTP-Binding Protein RhoF2
Rho Family GTPase Rif2 3     

External Ids:    HGNC: 157031   Entrez Gene: 545092   Ensembl: ENSG000001397257   UniProtKB: Q9HBH03   

Export aliases for RHOF gene to outside databases

Previous GC identifers: GC12M120615 GC12M120678 GC12M120700 GC12M119227


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHOF Gene:
RHOF (ras homolog family member F (in filopodia)) is a protein-coding gene. Diseases associated with RHOF include malaria. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RHOF_HUMAN, Q9HBH0
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive
GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions
cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based
morphology




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOF gene promoter:
         AREB6   USF1   p53   USF-1   HOXA5   Olf-1   MyoD   Lmo2   Ik-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOF promoter sequence
   Search Chromatin IP Primers for RHOF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

RHOF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOF gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122215:  view genomic region     (about GC identifiers)

Start:
122,215,660 bp from pter      End:
122,241,309 bp from pter
Size:
25,650 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHOF_HUMAN, Q9HBH0 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoF precursor  
Size: 211 amino acids; 23625 Da
Secondary accessions: Q8WVB1 Q9NXH6
Alternative splicing: 2 isoforms:  Q9HBH0-1   Q9HBH0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHOF: NX_Q9HBH0

Explore proteomics data for RHOF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RHOF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061907.2  
    ENSEMBL proteins: 
     ENSP00000267205   ENSP00000476444   ENSP00000476987   ENSP00000477391   ENSP00000476574  
     ENSP00000440397  
    Reactome Protein details: Q9HBH0

    RHOF Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RHOF
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RHOF
    GenScript Custom Purified and Recombinant Proteins Services for RHOF
    Novus Biologicals RHOF Protein
    Novus Biologicals RHOF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHOF

     
    Search eBioscience for Proteins for RHOF 

     
    antibodies-online proteins for RHOF (3 products) 

     
    antibodies-online peptides for RHOF

    RHOF Antibody Products:

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    ThermoFisher Antibodies for RHOF
    antibodies-online antibodies for RHOF (22 products) 

    RHOF Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOF
    Cloud-Clone Corp. CLIAs for RHOF
    Search eBioscience for ELISAs for RHOF 
    antibodies-online kits for RHOF (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9HBH0

    ProtoNet protein and cluster: Q9HBH0

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOF_HUMAN, Q9HBH0
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RHOF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOF_HUMAN, Q9HBH0
    Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive
    GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions
    cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based
    morphology

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS11084341
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RHOF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RHOF:
     Decreased TP53 protein express 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rhof):
     hematopoietic system 

    Find genes that share phenotypes with RHOF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rhoftm1.2Tac for RHOF

       genOway: Develop your customized and physiologically relevant rodent model for RHOF

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOF:
    hsa-mir-148b-3p (MIRT019255), hsa-mir-30a-5p (MIRT028419), hsa-mir-16-5p (MIRT031459)

    Block miRNA regulation of human, mouse, rat RHOF using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate RHOF:
    hsa-miR-498 hsa-miR-637 hsa-miR-625 hsa-miR-1252 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidRHOF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RHOF
    Predesigned siRNA for gene silencing in human, mouse, rat RHOF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOF

    Clone
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    OriGene clones in human, mouse for RHOF (see all 8)
    OriGene ORF clones in mouse, rat for RHOF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOF (NM_019034)
    Sino Biological Human cDNA Clone for RHOF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOF
    Addgene plasmids for RHOF 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RHOF
    Browse ESI BIO Cell Lines and PureStem Progenitors for RHOF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOF_HUMAN, Q9HBH0: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton NAS11084341
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    Find genes that share ontologies with RHOF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOF About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with RHOF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for RHOF
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHOF
    Interactions:

        Search GeneGlobe Interaction Network for RHOF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOF (Q9HBH03 ENSP000002672054) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIAPH3Q9NSV43I2D: score=1 
    ARHGAP15ENSP000002950954STRING: ENSP00000295095
    ARHGAP35ENSP000003857204STRING: ENSP00000385720
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    ARHGDIBENSP000002289454STRING: ENSP00000228945
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS11084341
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007015actin filament organization IDA11084341
    GO:0007165signal transduction ----

    Find genes that share ontologies with RHOF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOF

    1 HMDB Compound for RHOF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHOF gene: 
    NM_019034.2  

    Unigene Cluster for RHOF:

    Ras homolog family member F (in filopodia)
    Hs.644504  [show with all ESTs]
    Unigene Representative Sequence: NM_001080825
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267205(uc001ubb.3) ENST00000537265 ENST00000546227 ENST00000537171(uc001ubd.4)
    ENST00000541657 ENST00000535560 ENST00000545544
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RHOF using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate RHOF:
    hsa-miR-498 hsa-miR-637 hsa-miR-625 hsa-miR-1252 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidRHOF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RHOF
    Predesigned siRNA for gene silencing in human, mouse, rat RHOF
    Clone
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    OriGene clones in human, mouse for RHOF (see all 8)
    OriGene ORF clones in mouse, rat for RHOF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOF (NM_019034)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOF
    Addgene plasmids for RHOF 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOF
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOF
      QuantiTect SYBR Green Assays in human, mouse, rat RHOF
      QuantiFast Probe-based Assays in human, mouse, rat RHOF

    Additional mRNA sequence: 

    AK309447.1 BC018721.1 BC032529.1 BC035884.1 BC043395.1 BC069021.1 BC127768.1 BC127769.1 
    BX648084.1 

    10 DOTS entries:

    DT.411865  DT.100810676  DT.40128011  DT.121209862  DT.101981211  DT.100641705  DT.100720727  DT.91746743 
    DT.121209817  DT.209602 

    1 AceView cDNA sequence:

    AK130459 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGGCAGCC
    RHOF Expression
    About this image


    RHOF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    RHOF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644504
        Custom PCR Arrays for RHOF
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RHOF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOF gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhof1 , 5 ras homolog gene family, member f1, 5 87.36(n)1
    92.89(a)1
      5 (62.77 cM)5
    239121  NM_175092.31  NP_780301.11 
     1231030445 
    chicken
    (Gallus gallus)
    Aves RHOF1 ras homolog family member F (in filopodia) 69.54(n)
    74.16(a)
      416848  NM_001278152.1  NP_001265081.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOF6
    ras homolog family member F (in filopodia)
    68(a)
    1 ↔ 1
    GL343550.1(228074-237566)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165832 Xenopus laevis transcribed sequence with moderate similarity more 75.11(n)    BU914775.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rhof1 ras homolog gene family, member F 62.69(n)
    65.67(a)
      573655  NM_001020642.1  NP_001018478.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHO16
    GTP-binding protein of the rho subfamily of Ras-li...
    48(a)
    1 → many
    XVI(875368-875997) YPR165W


    ENSEMBL Gene Tree for RHOF (if available)
    TreeFam Gene Tree for RHOF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOF gene
    RHOB2  RND12  RHOA2  RHOD2  ENSG000002718102  RHOC2  RND32  RND22  
    Selected SIMAP similar genes for RHOF using alignment to 5 protein entries:     RHOF_HUMAN (see all proteins) (see all similar genes):
    RHOC    RHOJ    RHOA    RHOB    RAC3    RAC2
    CDC42    RHOQ    ARHG    RHOG    RHOH    ARHE
    RAC1    RND2    RND3    ARHH    RAB28    RHOD

    Find genes that share paralogs with RHOF           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RHOF
    PGOHUM00000251009


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOF (see all 240)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344150861,2
    C,F--122220559(+) GGTGAT/CGGGGC 1 -- int110Minor allele frequency- C:0.19NA WA CSA EA 371
    rs1893008441,2
    --122220621(+) TCTTCA/TGCCAG 1 -- int10--------
    rs734137281,2
    C,F--122220731(+) TAGACA/GGGACA 1 -- int19Minor allele frequency- G:0.19NA WA CSA EA 369
    rs2017158121,2
    C--122220864(+) CTCAA-/AAAAAT
            
    AAAAT
    1 -- int10--------
    rs1468792761,2
    C--122220896(+) ATTAAC/TATAAA 1 -- int10--------
    rs1808497821,2
    --122220909(+) ATTCAA/GCGCCT 1 -- int10--------
    rs746772221,2
    C--122220917(+) CCTCAG/ATTGCA 1 -- int12Minor allele frequency- A:0.08NA 122
    rs1392680031,2
    --122220945(+) GATGAA/GCTGCC 1 -- int10--------
    rs734137301,2
    C--122221026(+) CTGGAC/TGGTGG 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1498382671,2
    C--122221085(+) AGTCC-/TCGTCGTC 1 -- cds10--------

    HapMap Linkage Disequilibrium report for RHOF (122215660 - 122241309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RHOF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746494CNV Deletion23290073
    esv2746495CNV Deletion23290073
    esv2746493CNV Deletion23290073
    esv2670889CNV Deletion23128226
    nsv899566CNV Loss21882294
    nsv899567CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOF
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for RHOF:    
    About MalaCards
    malaria


    Find genes that share disorders with RHOF           About GenesLikeMe

    1 Novoseek inferred disease relationship for RHOF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malaria 62.7 3 17196595 (1), 14573641 (1), 12438381 (1)

    Genetic Association Database (GAD): RHOF

    Export disorders for RHOF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOF gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RHOF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements. (PubMed id 11084341)1, 2, 3, 9 Ellis S. and Mellor H. (Curr. Biol. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH. (PubMed id 22251971)1 Wong A.R....Frankel G. (MBio 2012)
    5. The small Rho GTPase Rif and actin cytoskeletal remodelling. (PubMed id 22260703)1 Fan L. and Mellor H. (Biochem. Soc. Trans. 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells. (PubMed id 20233848)1 Fan L....Mellor H. (J. Cell. Sci. 2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54509 HGNC: 15703 AceView: RHOF.1 Ensembl:ENSG00000139725 euGenes: HUgn54509
    ECgene: RHOF H-InvDB: RHOF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHOF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHOF gene:
    Search GeneIP for patents involving RHOF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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