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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOD Gene

protein-coding   GIFtS: 58
GCID: GC11P066824

Ras Homolog Family Member D

(Previous names: ras homolog gene family, member D)
(Previous symbol: ARHD)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Homolog Family Member D1 2     RHOM2
ARHD1 2 3 5     Rho2
Rho-Related Protein HP11 2 3     Ras Homolog D2
Ras Homolog Gene Family, Member D1 2     Ras Homolog Gene Family, Member A2
Rho-Related GTP-Binding Protein RhoD1 2     RhoHP13
RHOHP12 5     

External Ids:    HGNC: 6701   Entrez Gene: 299842   Ensembl: ENSG000001731567   OMIM: 6057815   UniProtKB: O002123   

Export aliases for RHOD gene to outside databases

Previous GC identifers: GC11P066600 GC11P066580 GC11P063152


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOD Gene:
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They
play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the
small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and
it may coordinate membrane transport with the function of the cytoskeleton. (provided by RefSeq, Jul 2008)

GeneCards Summary for RHOD Gene: 
RHOD (ras homolog family member D) is a protein-coding gene. Diseases associated with RHOD include neutrophil immunodeficiency syndrome, and clostridium difficile, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RHOD_HUMAN, O00212
Function: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton.
Participates in reorganization of actin cytoskeleton (By similarity)

Gene Wiki entry for RHOD (RhoD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOD gene promoter:
         Tal-1   Pax-5   RelA   NF-kappaB   Tal-1beta   E47   PPAR-alpha   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RHOD promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q14.3

RHOD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066824:  view genomic region     (about GC identifiers)

Start:
66,824,289 bp from pter      End:
66,839,488 bp from pter
Size:
15,200 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHOD_HUMAN, O00212 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoD precursor  
Size: 210 amino acids; 23413 Da
Subunit: In the GTP-bound form, interacts with DIAPH2 isoform 3. Interacts with PAK7/PAK5
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
1 PDB 3D structure from and Proteopedia for RHOD:
2J1L (3D)    

Explore the universe of human proteins at neXtProt for RHOD: NX_O00212

Explore proteomics data for RHOD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00212

  • RHOD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOD Protein Expression
    REFSEQ proteins: NP_055393.1  
    ENSEMBL proteins: 
     ENSP00000308576   ENSP00000431167   ENSP00000432003  
    Reactome Protein details: O00212
    Human Recombinant Protein Products for RHOD: 
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    Novus Biologicals RHOD Proteins
    Novus Biologicals RHOD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RHOD
    Cloud-Clone Corp. Proteins for RHOD 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    RHOD for ontologies           About GeneDecksing



    RHOD Antibody Products: 
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    Assay Products for RHOD: 
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    Cloud-Clone Corp. CLIAs for RHOD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O00212

    ProtoNet protein and cluster: O00212

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOD_HUMAN, O00212
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOD_HUMAN, O00212
    Function: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton.
    Participates in reorganization of actin cytoskeleton (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS9116026
    GO:0005525GTP binding IEA--
         
    RHOD for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOD
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RHOD
    SwitchGear 3'UTR luciferase reporter plasmidRHOD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOD

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RHOD (NM_014578)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHOD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    2Signaling by GPCR
    Signal Transduction0.55
    3Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for RHOD
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle


    1         Kegg Pathway  (Kegg details for RHOD):
        Axon guidance


    RHOD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHOD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for RHOD (O002123 ENSP000003085764) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157963, ENSP000002621604I2D: score=4 STRING: ENSP00000262160
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    DIAPH2O608793, ENSP000003213484I2D: score=3 STRING: ENSP00000321348
    HRASP011123, ENSP000003098454I2D: score=3 STRING: ENSP00000309845
    PLXNA1Q9UIW23, ENSP000002517724I2D: score=2 STRING: ENSP00000251772
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS9116026
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--

    RHOD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOD

    1 HMDB Compound for RHOD    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    10/81 Novoseek inferred chemical compound relationships for RHOD gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 82.2 90 9287351 (4), 18377644 (2), 9681826 (2), 8810315 (2) (see all 54)
    geranylgeranyl pyrophosphate 80.9 13 11864926 (2), 11470741 (1), 15389884 (1), 15853754 (1) (see all 9)
    gtp 80.4 108 18377644 (6), 11606631 (3), 9681826 (2), 8810315 (2) (see all 73)
    mdi-a 72.3 7 18829452 (2), 14765113 (2), 12857739 (1), 11509578 (1) (see all 5)
    y27632 68.8 3 16690038 (1), 16476521 (1), 19038009 (1)
    mevalonate 66.6 7 18817639 (1), 18427282 (1), 15389884 (1), 15853754 (1) (see all 6)
    guanosine 65.5 21 14752271 (1), 16242565 (1), 17024099 (1), 10092231 (1) (see all 21)
    actomyosin 64.7 12 12876554 (2), 16690038 (1), 12747959 (1), 20142793 (1) (see all 9)
    farnesyl diphosphate 64 8 11470741 (1), 15379639 (1), 15389884 (1), 15853754 (1) (see all 7)
    tyrosine 62 74 11799111 (6), 10912996 (3), 9182707 (2), 10333476 (2) (see all 53)

    Search CenterWatch for drugs/clinical trials and news about RHOD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHOD gene: 
    NM_014578.3  

    Unigene Cluster for RHOD:

    Ras homolog family member D
    Hs.15114  [show with all ESTs]
    Unigene Representative Sequence: NM_014578
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308831(uc001ojv.3) ENST00000533360 ENST00000532559

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RHOD
    SwitchGear 3'UTR luciferase reporter plasmidRHOD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOD
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    GenScript: all cDNA clones in your preferred vector: RHOD (NM_014578)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOD
    Sirion Biotech Customized lentivirus for stable overexpression of RHOD 
                         Customized lentivirus expression plasmids for stable overexpression of RHOD 
    Primer
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    OriGene qPCR primer pairs and template standards for RHOD
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOD
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOD

    Additional mRNA sequence: 

    AF498973.1 BC001338.1 

    4 DOTS entries:

    DT.313169  DT.100745305  DT.97840931  DT.95087569 

    24/91 AceView cDNA sequences (see all 91):

    CR619606 CA446579 AI080694 BM699832 BC001338 AI928332 BM845106 AA074341 
    BF438987 BM981905 BF436046 CN479735 CA433897 NM_014578 BM761353 CR611537 
    AI420794 CR621680 AI925601 BG775393 BF685556 BF589595 CF126943 AI869821 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RHOD    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                              
    SP2:        -     -               


    ECgene alternative splicing isoforms for RHOD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACGTCCA
    RHOD Expression
    About this image


    See RHOD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOD

    SOURCE GeneReport for Unigene cluster: Hs.15114

    UniProtKB/Swiss-Prot: RHOD_HUMAN, O00212
    Tissue specificity: Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several
    other tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOD gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhod1 , 5 ras homolog gene family, member D1, 5 82.7(n)1
    82.86(a)1
      19 (4.07 cM)5
    118541  NM_007485.41  NP_031511.11 
     44254595 
    chicken
    (Gallus gallus)
    Aves LOC7765041 rho-related GTP-binding protein RhoF-like 66.5(n)
    57.95(a)
      776504  XM_001236021.2  XP_001236022.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoL6
    rho-like
    33(a)
    1 → many
    3R(5322823-5328299)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHO16
    GTP-binding protein of the rho subfamily of Ras-li...
    44(a)
    1 → many
    XVI(875368-875997)


    ENSEMBL Gene Tree for RHOD (if available)
    TreeFam Gene Tree for RHOD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOD gene
    RHOB2  RHOA2  RND12  RHOF2  RHOC2  ENSG000002718102  RND22  RND32  
    18/72 SIMAP similar genes for RHOD using alignment to 3 protein entries:     RHOD_HUMAN (see all proteins) (see all similar genes):
    RHOB    RHOC    RHOA    CDC42    RAC3    RND2
    RAC2    RAC1    RHOJ    ARHG    RHOG    RHOV
    RND3    ARHE    RHOQ    ARHA    RHOH    RHOU

    RHOD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/299 SNPs in RHOD are shown (see all 299)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0584084
    ----see VAR_0584082 C R mis40--------
    rs57924021,2
    C--63158400(+) AGAAG-/AAAGGCC 1 -- int1 trp30--------
    rs1166126471,2
    F--66822365(+) GTCTAC/TCTCGT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs800734871,2
    C,F--66822372(+) TCGTGG/TTCTGA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs3696402491,2
    C--66822412(+) GAGGCA/GGATGG 1 -- us2k10--------
    rs171480511,2
    C,F,H--66822639(+) ACTGTA/GTAGCA 1 -- us2k112Minor allele frequency- G:0.01NA NS EA 1068
    rs1481559901,2
    --66822642(+) GTATAA/GCATGA 1 -- us2k10--------
    rs1879586071,2
    --66822667(+) GTCATA/TACAGA 1 -- us2k10--------
    rs1911309901,2
    --66822671(+) TTACAC/GAGATT 1 -- us2k10--------
    rs785242821,2
    C--66822685(+) CCTATA/GGCAAC 1 -- us2k12Minor allele frequency- G:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for RHOD (66824289 - 66839488 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RHOD: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOD
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605781    OMIM disorders: --

    20/60 diseases for RHOD (see all 60):    About MalaCards
    neutrophil immunodeficiency syndrome    clostridium difficile    polyploidy    cerebral infarction
    breast adenocarcinoma    developmental disabilities    tuberous sclerosis    tuberous sclerosis complex
    fibrosarcoma    lymphangioleiomyomatosis    wiskott-aldrich syndrome    myotonic dystrophy
    vascular disease    cholera    clear cell renal cell carcinoma    familial breast cancer
    testicular cancer    hypercholesterolemia    neurofibromatosis    gout


    RHOD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/61 Novoseek inferred disease relationships for RHOD gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 62.6 5 8625410 (1), 12680752 (1), 18212360 (1), 11580754 (1)
    colitis pseudomembranous 37.3 2 11119561 (1), 8890188 (1)
    metastasis 36.2 23 12445208 (2), 9042860 (1), 14716844 (1), 16900393 (1) (see all 21)
    cancer 24.8 37 14999150 (3), 19355891 (3), 16234258 (2), 15739201 (2) (see all 27)
    tumors 24.5 60 15588766 (3), 19166232 (3), 15013523 (2), 10328216 (2) (see all 43)
    carcinosarcoma 256 walker 24.3 1 15950966 (1)
    atherosclerosis 21 4 15706042 (1), 16640963 (1), 18222728 (1), 18561944 (1)
    radiation enteritis 20.5 2 15710979 (2)
    myotonic dystrophy 17.8 3 15894391 (1), 10542285 (1)
    astrocytoma 16.8 2 11462805 (2)

    Genetic Association Database (GAD): RHOD

    Export disorders for RHOD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOD gene, integrated from 9 sources (see all 826):
    (articles sorted by number of sources associating them with RHOD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. (PubMed id 9116026)1, 2, 3 Shimizu F.... Nakamura Y. (1997)
    2. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. RhoD regulates endosome dynamics through diaphanous-related formin and Src tyrosine kinase. (PubMed id 12577064)1, 2 Gasman S.... Zerial M. (2003)
    5. A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization. (PubMed id 17029007)1, 9 Ito Y....Tada A. (2007)
    6. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. (PubMed id 14749388)1, 9 Jaffe A.B.... Hall A. (2004)
    7. Stabilization of anaphase midzone microtubules is reg ulated by Rho during cytokinesis in human fibrosarcoma cells. (PubMed id 19576212)1, 9 Kanada M....Uyeda T.Q. (2009)
    8. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. (PubMed id 17916560)1, 9 Tong Y....Buck M. (2007)
    9. Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. (PubMed id 16651639)1, 9 Birukova A.A....Birukov K.G. (2006)
    10. Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse. (PubMed id 11784792)1, 9 Zanata S.M....Puschel A.W. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29984 HGNC: 670 AceView: RHOD Ensembl:ENSG00000173156 euGenes: HUgn29984
    ECgene: RHOD Kegg: 29984 H-InvDB: RHOD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHOD gene:
    Search GeneIP for patents involving RHOD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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