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Aliases for RHOD Gene

Aliases for RHOD Gene

  • Ras Homolog Family Member D 2 3 5
  • Rho-Related Protein HP1 2 3 4
  • Ras Homolog Gene Family, Member D 2 3
  • RHOHP1 3 4
  • ARHD 3 4
  • Rho-Related GTP-Binding Protein RhoD 2
  • Ras Homolog Gene Family, Member A 3
  • Ras Homolog D 3
  • RHOM 3
  • Rho 3

External Ids for RHOD Gene

Previous HGNC Symbols for RHOD Gene

  • ARHD

Previous GeneCards Identifiers for RHOD Gene

  • GC11P066600
  • GC11P066580
  • GC11P066824
  • GC11P063152

Summaries for RHOD Gene

Entrez Gene Summary for RHOD Gene

  • Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for RHOD Gene

RHOD (Ras Homolog Family Member D) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOD Gene

  • Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.

Gene Wiki entry for RHOD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOD Gene

Genomics for RHOD Gene

Regulatory Elements for RHOD Gene

Promoters for RHOD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHOD on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOD Gene

Chromosome:
11
Start:
67,056,818 bp from pter
End:
67,072,017 bp from pter
Size:
15,200 bases
Orientation:
Plus strand

Genomic View for RHOD Gene

Genes around RHOD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOD Gene

Proteins for RHOD Gene

  • Protein details for RHOD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00212-RHOD_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoD
    Protein Accession:
    O00212

    Protein attributes for RHOD Gene

    Size:
    210 amino acids
    Molecular mass:
    23413 Da
    Quaternary structure:
    • Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK7/PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.

    Three dimensional structures from OCA and Proteopedia for RHOD Gene

neXtProt entry for RHOD Gene

Proteomics data for RHOD Gene at MOPED

Post-translational modifications for RHOD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RHOD Gene

Domains & Families for RHOD Gene

Gene Families for RHOD Gene

Suggested Antigen Peptide Sequences for RHOD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00212

UniProtKB/Swiss-Prot:

RHOD_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOD: view

Function for RHOD Gene

Molecular function for RHOD Gene

UniProtKB/Swiss-Prot Function:
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
genes like me logo Genes that share phenotypes with RHOD: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RHOD Gene

Localization for RHOD Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOD Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250 UniProtKB:P97348}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOD Gene COMPARTMENTS Subcellular localization image for RHOD gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RHOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RHOD: view

Pathways & Interactions for RHOD Gene

genes like me logo Genes that share pathways with RHOD: view

Gene Ontology (GO) - Biological Process for RHOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0007165 signal transduction IEA --
GO:0007266 Rho protein signal transduction TAS 9116026
GO:0030335 positive regulation of cell migration IMP 23087206
GO:0048041 focal adhesion assembly IMP 23087206
genes like me logo Genes that share ontologies with RHOD: view

No data available for SIGNOR curated interactions for RHOD Gene

Drugs & Compounds for RHOD Gene

(39) Drugs for RHOD Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(43) Additional Compounds for RHOD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOD: view

Transcripts for RHOD Gene

mRNA/cDNA for RHOD Gene

Unigene Clusters for RHOD Gene

Ras homolog family member D:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: - -

Relevant External Links for RHOD Gene

GeneLoc Exon Structure for
RHOD
ECgene alternative splicing isoforms for
RHOD

Expression for RHOD Gene

mRNA expression in normal human tissues for RHOD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOD Gene

This gene is overexpressed in Esophagus - Mucosa (x9.4) and Liver (x7.0).

Protein differential expression in normal tissues from HIPED for RHOD Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOD Gene



SOURCE GeneReport for Unigene cluster for RHOD Gene Hs.15114

mRNA Expression by UniProt/SwissProt for RHOD Gene

O00212-RHOD_HUMAN
Tissue specificity: Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
genes like me logo Genes that share expression patterns with RHOD: view

Protein tissue co-expression partners for RHOD Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RHOD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOD 36
  • 100 (a)
OneToOne
RHOD 35
  • 99.84 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RHOD 35
  • 89.37 (n)
  • 89.05 (a)
RHOD 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOD 36
  • 86 (a)
OneToOne
RHOD 35
  • 88.84 (n)
  • 87.08 (a)
mouse
(Mus musculus)
Mammalia Rhod 35
  • 82.7 (n)
  • 82.86 (a)
Rhod 16
Rhod 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOD 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhod 35
  • 83.17 (n)
  • 82.86 (a)
chicken
(Gallus gallus)
Aves RHOD 36
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 36
  • 46 (a)
OneToMany
Species with no ortholog for RHOD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RHOD Gene

ENSEMBL:
Gene Tree for RHOD (if available)
TreeFam:
Gene Tree for RHOD (if available)

Paralogs for RHOD Gene

genes like me logo Genes that share paralogs with RHOD: view

Variants for RHOD Gene

Sequence variations from dbSNP and Humsavar for RHOD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs947941 -- 67,055,308(-) CTGTC(A/G)TCAGG upstream-variant-2KB
rs2282502 -- 67,066,781(+) CCTGA(C/G/T)GCCAG intron-variant, reference, synonymous-codon
rs4930408 -- 67,061,792(+) TGTGT(A/G)TATAT intron-variant
rs4930409 - 67,070,494(+) ACCTG(C/T)GCAAG reference, missense
rs5006007 -- 67,063,091(+) GAAAG(C/G)CCCAA intron-variant

Variation tolerance for RHOD Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOD Gene

HapMap Linkage Disequilibrium report
RHOD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RHOD Gene

Disorders for RHOD Gene

Relevant External Links for RHOD

Genetic Association Database (GAD)
RHOD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOD

No disorders were found for RHOD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOD Gene

Publications for RHOD Gene

  1. Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. (PMID: 9116026) Shimizu F. … Nakamura Y. (Biochim. Biophys. Acta 1997) 2 3 4 67
  2. Stabilization of anaphase midzone microtubules is regulated by Rho during cytokinesis in human fibrosarcoma cells. (PMID: 19576212) Kanada M. … Uyeda T.Q. (Exp. Cell Res. 2009) 3 23
  3. A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization. (PMID: 17029007) Ito Y. … Tada A. (Mol. Cell. Biochem. 2007) 3 23
  4. Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture. (PMID: 17342762) Lakshman N. … Petroll W.M. (Cell Motil. Cytoskeleton 2007) 3 23
  5. The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase. (PMID: 15187129) Flaxenburg J.A. … Pal S. (J. Immunol. 2004) 3 23

Products for RHOD Gene

Sources for RHOD Gene

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