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Aliases for RHOD Gene

Aliases for RHOD Gene

  • Ras Homolog Family Member D 2 3
  • Rho-Related Protein HP1 2 3 4
  • RHOHP1 3 4 6
  • ARHD 3 4 6
  • Rho-Related GTP-Binding Protein RhoD 2 3
  • Ras Homolog Gene Family, Member D 2 3
  • Ras Homolog Gene Family, Member A 3
  • Ras Homolog D 3
  • RHOM 3
  • Rho 3

External Ids for RHOD Gene

Previous Symbols for RHOD Gene

  • ARHD

Summaries for RHOD Gene

Entrez Gene Summary for RHOD Gene

  • Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for RHOD Gene

RHOD (Ras Homolog Family Member D) is a Protein Coding gene. Diseases associated with RHOD include neutrophil immunodeficiency syndrome and hepatocellular carcinoma. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOD Gene

  • Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.

Gene Wiki entry for RHOD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOD Gene

Genomics for RHOD Gene

Genomic Location for RHOD Gene

Start:
67,056,818 bp from pter
End:
67,072,017 bp from pter
Size:
15,200 bases
Orientation:
Plus strand

Genomic View for RHOD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOD Gene

Regulatory Elements for RHOD Gene

Proteins for RHOD Gene

  • Protein details for RHOD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00212-RHOD_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoD
    Protein Accession:
    O00212
    Secondary Accessions:

    Protein attributes for RHOD Gene

    Size:
    210 amino acids
    Molecular mass:
    23413 Da
    Quaternary structure:
    • Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK7/PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.

    Three dimensional structures from OCA and Proteopedia for RHOD Gene

neXtProt entry for RHOD Gene

Proteomics data for RHOD Gene at MOPED

Post-translational modifications for RHOD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOD Gene

Domains for RHOD Gene

UniProtKB/Swiss-Prot:

RHOD_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • O00212
genes like me logo Genes that share domains with RHOD: view

No data available for Gene Families for RHOD Gene

Function for RHOD Gene

Molecular function for RHOD Gene

UniProtKB/Swiss-Prot Function: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.

Gene Ontology (GO) - Molecular Function for RHOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 9116026
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with RHOD: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RHOD Gene

Localization for RHOD Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOD Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250 UniProtKB:P97348}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOD Gene COMPARTMENTS Subcellular localization image for RHOD gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 3
cytoskeleton 2
endosome 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RHOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with RHOD: view

Pathways for RHOD Gene

genes like me logo Genes that share pathways with RHOD: view

Pathways by source for RHOD Gene

Gene Ontology (GO) - Biological Process for RHOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006605 protein targeting IEA --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RHOD: view

Compounds for RHOD Gene

(1) HMDB Compounds for RHOD Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(81) Novoseek inferred chemical compound relationships for RHOD Gene

Compound -log(P) Hits PubMed IDs
gdp 82.2 66
geranylgeranyl pyrophosphate 80.9 10
gtp 80.4 87
mdi-a 72.3 7
y27632 68.8 3
genes like me logo Genes that share compounds with RHOD: view

Transcripts for RHOD Gene

mRNA/cDNA for RHOD Gene

Unigene Clusters for RHOD Gene

Ras homolog family member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: - -

Relevant External Links for RHOD Gene

GeneLoc Exon Structure for
RHOD
ECgene alternative splicing isoforms for
RHOD

Expression for RHOD Gene

mRNA expression in normal human tissues for RHOD Gene

mRNA differential expression in normal tissues according to GTEx for RHOD Gene

This gene is overexpressed in Esophagus - Mucosa (9.4) and Liver (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOD Gene

SOURCE GeneReport for Unigene cluster for RHOD Gene Hs.15114

mRNA Expression by UniProt/SwissProt for RHOD Gene

O00212-RHOD_HUMAN
Tissue specificity: Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues
genes like me logo Genes that share expressions with RHOD: view

Orthologs for RHOD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOD 36
  • 99.84 (n)
  • 100 (a)
RHOD 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOD 36
  • 89.37 (n)
  • 89.05 (a)
RHOD 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOD 36
  • 88.84 (n)
  • 87.08 (a)
RHOD 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhod 36
  • 82.7 (n)
  • 82.86 (a)
Rhod 16
Rhod 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOD 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhod 36
  • 83.17 (n)
  • 82.86 (a)
chicken
(Gallus gallus)
Aves RHOD 37
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 37
  • 46 (a)
OneToMany
Species with no ortholog for RHOD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RHOD Gene

ENSEMBL:
Gene Tree for RHOD (if available)
TreeFam:
Gene Tree for RHOD (if available)

Paralogs for RHOD Gene

Paralogs for RHOD Gene

genes like me logo Genes that share paralogs with RHOD: view

Variants for RHOD Gene

Sequence variations from dbSNP and Humsavar for RHOD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs947941 -- 67,055,308(-) CTGTC(A/G)TCAGG upstream-variant-2KB
rs1044991 -- 67,071,933(+) ATGTT(C/T)TTAGG utr-variant-3-prime
rs2282502 -- 67,066,781(+) CCTGA(C/G/T)GCCAG intron-variant, reference, missense, synonymous-codon
rs2298459 -- 67,070,674(+) GCGGT(C/T)GTCTT intron-variant
rs3923203 -- 67,067,723(+) gaatc(C/G)gtcta intron-variant

Relevant External Links for RHOD Gene

HapMap Linkage Disequilibrium report
RHOD

No data available for Structural Variations from Database of Genomic Variants (DGV) for RHOD Gene

Disorders for RHOD Gene

(61) Novoseek inferred disease relationships for RHOD Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 62.6 4
colitis pseudomembranous 37.3 2
metastasis 36.2 22
cancer 24.8 33
tumors 24.5 51

Relevant External Links for RHOD

Genetic Association Database (GAD)
RHOD
genes like me logo Genes that share disorders with RHOD: view

No data available for UniProtKB/Swiss-Prot for RHOD Gene

Publications for RHOD Gene

  1. Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. (PMID: 9116026) Shimizu F. … Nakamura Y. (Biochim. Biophys. Acta 1997) 2 3 4
  2. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. (PMID: 23087206) Gad A.K. … AspenstrAPm P. (Mol. Biol. Cell 2012) 3 4
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 49
  4. Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. (PMID: 23454120) Nehru V. … AspenstrAPm P. (Biochem. Biophys. Res. Commun. 2013) 3 4
  5. RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor. (PMID: 24102721) Nehru V. … Aspenstroem P. (Traffic 2013) 3 4

Products for RHOD Gene

  • Addgene plasmids for RHOD

Sources for RHOD Gene

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