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Aliases for RHOD Gene

Aliases for RHOD Gene

  • Ras Homolog Family Member D 2 3 5
  • Rho-Related Protein HP1 2 3 4
  • Rho-Related GTP-Binding Protein RhoD 2 3
  • Ras Homolog Gene Family, Member D 2 3
  • RHOHP1 3 4
  • ARHD 3 4
  • Ras Homolog Gene Family, Member A 3
  • Ras Homolog D 3
  • RHOM 3
  • Rho 3

External Ids for RHOD Gene

Previous HGNC Symbols for RHOD Gene

  • ARHD

Previous GeneCards Identifiers for RHOD Gene

  • GC11P066600
  • GC11P066580
  • GC11P066824
  • GC11P063152

Summaries for RHOD Gene

Entrez Gene Summary for RHOD Gene

  • Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for RHOD Gene

RHOD (Ras Homolog Family Member D) is a Protein Coding gene. Diseases associated with RHOD include Neutrophil Immunodeficiency Syndrome. Among its related pathways are Phospholipase-C Pathway and Development ERBB-family signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOF.

UniProtKB/Swiss-Prot for RHOD Gene

  • Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.

Gene Wiki entry for RHOD Gene

Additional gene information for RHOD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOD Gene

Genomics for RHOD Gene

Regulatory Elements for RHOD Gene

Enhancers for RHOD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H067052 1.4 ENCODE dbSUPER 36.5 -1.4 -1366 5.2 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 ZNF2 ENSG00000258297 RHOD RBM14 RBM4 KDM2A MRPL11 ENSG00000255320 CORO1B ENSG00000245156 SSH3
GH11H067310 1.5 Ensembl ENCODE dbSUPER 22.9 +255.8 255763 4.4 PKNOX1 ATF1 ARNT SIN3A ZBTB7B ZNF766 ELK1 GATA2 FOS ATF7 RHOD PTPRCAP LRP5 RAD9A CARNS1 RIN1 LOC100130987 SSH3
GH11H067077 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +21.5 21524 2.5 TBP SREBF2 KLF17 BATF BRCA1 EGR1 ZNF366 FOS RUNX3 DEK RHOD KDM2A ANKRD13D CDK2AP2 GRK2 RBM4 CLCF1 SSH3 TMEM134 PITPNM1
GH11H066880 1.4 Ensembl ENCODE dbSUPER 22.4 -174.3 -174273 3.7 TBP PKNOX1 FOXA2 RB1 NFIB SREBF2 ARID4B ZNF76 SIN3A BMI1 RHOD C11orf80 ACTN3 CTSF RAD9A SART1 RCE1 LRFN4 PC RNU7-23P
GH11H067026 1.2 ENCODE dbSUPER 23.3 -28.8 -28778 2.9 FOXA2 PKNOX1 TBL1XR1 NFIB SIN3A NFXL1 BMI1 RAD21 ZBTB7B YY1 RHOD SYT12 RNU7-23P PC LRFN4 MIR6860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOD on UCSC Golden Path with GeneCards custom track

Promoters for RHOD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041054 182 801 GTF2F1 CTCF TFAP4 PKNOX1 SREBF2 MAX RAD21 RFX5 ZKSCAN1 TEAD3

Genomic Locations for RHOD Gene

Genomic Locations for RHOD Gene
chr11:67,056,818-67,072,017
(GRCh38/hg38)
Size:
15,200 bases
Orientation:
Plus strand
chr11:66,824,289-66,839,488
(GRCh37/hg19)

Genomic View for RHOD Gene

Genes around RHOD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOD Gene

Proteins for RHOD Gene

  • Protein details for RHOD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00212-RHOD_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoD
    Protein Accession:
    O00212

    Protein attributes for RHOD Gene

    Size:
    210 amino acids
    Molecular mass:
    23413 Da
    Quaternary structure:
    • Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.

    Three dimensional structures from OCA and Proteopedia for RHOD Gene

neXtProt entry for RHOD Gene

Post-translational modifications for RHOD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOD Gene

Domains & Families for RHOD Gene

Gene Families for RHOD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RHOD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00212

UniProtKB/Swiss-Prot:

RHOD_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOD: view

Function for RHOD Gene

Molecular function for RHOD Gene

UniProtKB/Swiss-Prot Function:
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.

Phenotypes From GWAS Catalog for RHOD Gene

Gene Ontology (GO) - Molecular Function for RHOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with RHOD: view
genes like me logo Genes that share phenotypes with RHOD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOD

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RHOD Gene

Localization for RHOD Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOD Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250 UniProtKB:P97348}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOD gene
Compartment Confidence
plasma membrane 5
cytosol 5
endosome 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RHOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOD Gene

Pathways & Interactions for RHOD Gene

genes like me logo Genes that share pathways with RHOD: view

Gene Ontology (GO) - Biological Process for RHOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction TAS 9116026
GO:0030032 lamellipodium assembly IMP 23087206
GO:0030335 positive regulation of cell migration IMP 23087206
genes like me logo Genes that share ontologies with RHOD: view

No data available for SIGNOR curated interactions for RHOD Gene

Drugs & Compounds for RHOD Gene

(45) Drugs for RHOD Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(37) Additional Compounds for RHOD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOD: view

Transcripts for RHOD Gene

mRNA/cDNA for RHOD Gene

Unigene Clusters for RHOD Gene

Ras homolog family member D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOD

Alternative Splicing Database (ASD) splice patterns (SP) for RHOD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: - -

Relevant External Links for RHOD Gene

GeneLoc Exon Structure for
RHOD
ECgene alternative splicing isoforms for
RHOD

Expression for RHOD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOD Gene

This gene is overexpressed in Esophagus - Mucosa (x9.4) and Liver (x7.0).

Protein differential expression in normal tissues from HIPED for RHOD Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RHOD Gene



Protein tissue co-expression partners for RHOD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOD Gene:

RHOD

SOURCE GeneReport for Unigene cluster for RHOD Gene:

Hs.15114

mRNA Expression by UniProt/SwissProt for RHOD Gene:

O00212-RHOD_HUMAN
Tissue specificity: Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.

Evidence on tissue expression from TISSUES for RHOD Gene

  • Muscle(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with RHOD: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOD Gene

Orthologs for RHOD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOD 33 34
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia RHOD 33 34
  • 89.37 (n)
dog
(Canis familiaris)
Mammalia RHOD 33 34
  • 88.84 (n)
rat
(Rattus norvegicus)
Mammalia Rhod 33
  • 83.17 (n)
mouse
(Mus musculus)
Mammalia Rhod 33 16 34
  • 82.7 (n)
oppossum
(Monodelphis domestica)
Mammalia RHOD 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOD 34
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 34
  • 46 (a)
OneToMany
Species where no ortholog for RHOD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RHOD Gene

ENSEMBL:
Gene Tree for RHOD (if available)
TreeFam:
Gene Tree for RHOD (if available)

Paralogs for RHOD Gene

Variants for RHOD Gene

Sequence variations from dbSNP and Humsavar for RHOD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000015276 -- 67,058,287(+) TCTCC(C/T)GCCTC intron-variant
rs1000088422 -- 67,058,474(+) CCCAG(C/T)CAATT intron-variant
rs1000260392 -- 67,062,572(+) TCTCC(A/G)TCTTC intron-variant
rs1000326106 -- 67,063,191(+) TCAAG(A/G)CCAGC intron-variant
rs1000513718 -- 67,071,848(+) CGGTC(C/G)CGGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RHOD Gene

Variant ID Type Subtype PubMed ID
nsv555226 CNV gain 21841781

Variation tolerance for RHOD Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOD Gene

Disorders for RHOD Gene

MalaCards: The human disease database

(1) MalaCards diseases for RHOD Gene - From: GeneCards

Disorder Aliases PubMed IDs
neutrophil immunodeficiency syndrome
  • neuid
- elite association - COSMIC cancer census association via MalaCards
Search RHOD in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHOD

Genetic Association Database (GAD)
RHOD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOD
genes like me logo Genes that share disorders with RHOD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOD Gene

Publications for RHOD Gene

  1. Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. (PMID: 9116026) Shimizu F … Nakamura Y (Biochimica et biophysica acta 1997) 2 3 4 60
  2. Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. (PMID: 23454120) Nehru V … Aspenström P (Biochemical and biophysical research communications 2013) 3 4 60
  3. RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor. (PMID: 24102721) Nehru V … Aspenström P (Traffic (Copenhagen, Denmark) 2013) 3 4 60
  4. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. (PMID: 23087206) Gad AK … Aspenström P (Molecular biology of the cell 2012) 3 4 60
  5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 45 60

Products for RHOD Gene

  • Addgene plasmids for RHOD

Sources for RHOD Gene

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