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RHOC Gene

protein-coding   GIFtS: 66
GCID: GC01M113243

Ras Homolog Family Member C

(Previous names: ras homolog gene family, member C)
(Previous symbols: ARH9, ARHC)
  See RHOC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member C1 2     Oncogene RHO H92
ARH91 2 3 5     RAS-Related Homolog 92
ARHC1 2 3 5     Rho-Related GTP-Binding Protein RhoC2
Ras Homolog Gene Family, Member C1 2     RhoC GTPase2
Rho CDNA Clone 92 3     Small GTP Binding Protein RhoC2
RHOH92 5     h93
H92     

External Ids:    HGNC: 6691   Entrez Gene: 3892   Ensembl: ENSG000001553667   OMIM: 1653805   UniProtKB: P081343   

Export aliases for RHOC gene to outside databases

Previous GC identifers: GC01M112544 GC01M112955 GC01M111103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHOC Gene:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active
GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote
reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded
by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought
to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and
metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided
by RefSeq, Jul 2008)

GeneCards Summary for RHOC Gene:
RHOC (ras homolog family member C) is a protein-coding gene. Diseases associated with RHOC include non-small cell lung carcinoma, and hepatocellular carcinoma. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134
Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal
adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin
contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial
epithelial cells

Gene Wiki entry for RHOC (RhoC) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOC gene promoter:
         AP-1   p53   ATF-2   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOC promoter sequence
   Search Chromatin IP Primers for RHOC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

RHOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M113243:  view genomic region     (about GC identifiers)

Start:
113,243,728 bp from pter      End:
113,250,056 bp from pter
Size:
6,329 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoC precursor  
Size: 193 amino acids; 22006 Da
Subunit: Interacts with RTKN (By similarity). Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2. Interacts with
ARHGDIA
4 PDB 3D structures from and Proteopedia for RHOC:
1Z2C (3D)        2GCN (3D)        2GCO (3D)        2GCP (3D)    
Secondary accessions: B3KSW1 Q6ICN3

Explore the universe of human proteins at neXtProt for RHOC: NX_P08134

Explore proteomics data for RHOC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys104
  • Modification sites at PhosphoSitePlus

  • See RHOC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001036143.1  NP_001036144.1  NP_786886.1  

    ENSEMBL proteins: 
     ENSP00000345236   ENSP00000358656   ENSP00000285735   ENSP00000431392   ENSP00000358652  
     ENSP00000358651   ENSP00000358650   ENSP00000434310   ENSP00000358646   ENSP00000390823  
     ENSP00000436240   ENSP00000399424   ENSP00000432209   ENSP00000434877   ENSP00000395791  
     ENSP00000358647  
    Reactome Protein details: P08134

    RHOC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RHOC
    OriGene Protein Over-expression Lysate for RHOC
    OriGene MassSpec for RHOC
    OriGene Custom Protein Services for RHOC
    GenScript Custom Purified and Recombinant Proteins Services for RHOC
    Novus Biologicals RHOC Proteins
    Novus Biologicals RHOC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RHOC
    Cloud-Clone Corp. Proteins for RHOC

     
    Search eBioscience for Proteins for RHOC 

    RHOC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RHOC
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RHOC 
    OriGene Antibodies for RHOC
    OriGene Custom Antibody Services for RHOC
    Novus Biologicals RHOC Antibodies
    Abcam antibodies for RHOC (P08134, P61586)
    Cloud-Clone Corp. Antibodies for RHOC
    ThermoFisher Antibody for RHOC
    LSBio Antibodies in human, mouse, rat for RHOC

    RHOC Assay Products:

    EMD Millipore Kits and Assays for the Analysis of RHOC
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    GenScript Custom Assay Services for RHOC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOC
    Cloud-Clone Corp. CLIAs for RHOC
    Search eBioscience for ELISAs for RHOC 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P08134

    ProtoNet protein and cluster: P08134

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RHOC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOC_HUMAN, P08134
    Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal
    adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin
    contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial
    epithelial cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RHOC           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhoc):
     cellular  immune system  tumorigenesis 

    Find genes that share phenotypes with RHOC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rhoctm1Mak for RHOC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHOC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHOC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOC

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOC:
    hsa-mir-455-3p (MIRT037911), hsa-mir-372-3p (MIRT005932), hsa-mir-138-5p (MIRT000495), hsa-mir-302b-3p (MIRT005933), hsa-mir-1 (MIRT023854), hsa-mir-124-3p (MIRT022794)

    Block miRNA regulation of human, mouse, rat RHOC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOC (see all 26):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidRHOC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RHOC
    Predesigned siRNA for gene silencing in human, mouse, rat RHOC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOC

    Clone
    Products:
         
    OriGene clones in human, mouse for RHOC (see all 17)
    OriGene ORF clones in mouse, rat for RHOC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RHOC (NM_175744)
    Sino Biological Human cDNA Clone for RHOC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOC
    Addgene plasmids for RHOC 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RHOC
    Browse ESI BIO Cell Lines and PureStem Progenitors for RHOC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOC_HUMAN, P08134: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cleavage furrow.
    Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    Find genes that share ontologies with RHOC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOC About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90
    3L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    4Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    5p75 NTR receptor-mediated signalling
    G alpha (12/13) signalling events0.44


    Find genes that share SuperPaths with RHOC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RHOC
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RHOC (see all 33)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for RHOC
        Cytoskeletal Signaling

    2 BioSystems Pathways for RHOC
        Spinal Cord Injury
    Signaling events mediated by PRL


    3 Reactome Pathways for RHOC
        Sema4D induced cell migration and growth-cone collapse
    G alpha (12/13) signalling events
    Rho GTPase cycle


        Pathway & Disease-focused RT2 Profiler PCR Array including RHOC: 
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RHOC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOC (P081342, 3 ENSP000002857354) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNKSR1Q969H42, 3, ENSP000003546094MINT-56517 I2D: score=2 STRING: ENSP00000354609
    ARHGAP1Q079603, ENSP000003104914I2D: score=4 STRING: ENSP00000310491
    CAV1Q031353, ENSP000003391914I2D: score=1 STRING: ENSP00000339191
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    LNX1Q8TBB13, ENSP000002639254I2D: score=1 STRING: ENSP00000263925
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IDA16236794
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with RHOC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for RHOC
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOC

    3 Novoseek inferred chemical compound relationships for RHOC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 57.9 2 19642867 (1)
    gtp 36.8 6 18377644 (2), 19642867 (1)
    vegf 18.4 3 14696649 (1), 15602803 (1)



    Find genes that share compounds with RHOC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHOC gene (3 alternative transcripts): 
    NM_001042678.1  NM_001042679.1  NM_175744.4  

    Unigene Clusters for RHOC:

    Ras homolog family member C
    Hs.502659  [show with all ESTs], Hs.658289  [show with all ESTs]
    Unigene Representative Sequences: AK094474, BI000596
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000339083(uc001ecq.1 uc001ecr.1) ENST00000369642 ENST00000285735(uc009wgk.1)
    ENST00000468093 ENST00000369638 ENST00000369637 ENST00000369636 ENST00000473074
    ENST00000484280 ENST00000369632 ENST00000425265 ENST00000534717 ENST00000436685
    ENST00000528831 ENST00000484054 ENST00000414971 ENST00000478447 ENST00000527563

    miRNA
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    Block miRNA regulation of human, mouse, rat RHOC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOC (see all 26):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidRHOC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RHOC
    Predesigned siRNA for gene silencing in human, mouse, rat RHOC
    Clone
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    OriGene clones in human, mouse for RHOC (see all 17)
    OriGene ORF clones in mouse, rat for RHOC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RHOC (NM_175744)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOC
    Addgene plasmids for RHOC 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOC
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOC
      QuantiTect SYBR Green Assays in human, mouse, rat RHOC
      QuantiFast Probe-based Assays in human, mouse, rat RHOC

    Additional mRNA sequence: AF085893.1 

    Selected DOTS entries (see all 40):

    DT.219329  DT.99926463  DT.92471967  DT.101986475  DT.95102696  DT.100673039  DT.121433304  DT.121433252 
    DT.95285439  DT.428367  DT.87079300  DT.100673034  DT.100673046  DT.121433212  DT.121433215  DT.100759962 
    DT.121433298  DT.92471807  DT.121433186  DT.95091621  DT.95103840  DT.99926455  DT.100716118  DT.121433164 

    Selected AceView cDNA sequences (see all 712):

    AI571453 AI826462 BF724390 NM_005167 AA359487 AK093270 BI827072 CD368949 
    CA307812 CA414036 BU521068 BM720210 BQ893521 BG032523 BG168140 BM854662 
    BM563781 BC064628 BU730932 AI188506 BU528589 AW079367 CR601446 BQ051765 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RHOC (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h
    SP1:                    -     -     -     -           -     -     -     -     -           -                                                                     
    SP2:                    -     -     -                 -     -     -     -     -           -                                                                     
    SP3:                                -     -           -     -     -     -     -           -                                                                     
    SP4:                                      -           -     -     -     -     -           -                                                                     
    SP5:                                                  -     -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for RHOC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RHOC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGGCT
    RHOC Expression
    About this image


    RHOC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    RHOC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOC Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.502659 Hs.658289
        Pathway & Disease-focused RT2 Profiler PCR Array including RHOC: 
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHOC
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOC
    QuantiTect SYBR Green Assays in human, mouse, rat RHOC
    QuantiFast Probe-based Assays in human, mouse, rat RHOC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOC gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhoc1 , 5 ras homolog gene family, member C1, 5 92.06(n)1
    100(a)1
      3 (45.86 cM)5
    118531  NM_007484.21  NP_031510.21 
     1047890115 
    chicken
    (Gallus gallus)
    Aves RHOC1 ras homolog gene family, member C 85.15(n)
    96.89(a)
      395869  NM_001029849.1  NP_001025020.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOC6
    ras homolog family member C
    95(a)
    1 ↔ 1
    4(128234464-128276561)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044696.12   -- 82.25(n)    BC044696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640152 similar to ras homolog gene family, member C 81.4(n)   394125  BC053200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rho11 Rho1 72.16(n)
    86.7(a)
      36775  NM_206129.1  NP_995851.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rho-11 rho-1 70.49(n)
    84.9(a)
      178458  NM_070558.6  NP_502959.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHO16
    GTP-binding protein of the rho subfamily of Ras-li...
    65(a)
    1 → many
    XVI(875368-875997) YPR165W


    ENSEMBL Gene Tree for RHOC (if available)
    TreeFam Gene Tree for RHOC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOC gene
    RHOB2  RND12  RHOA2  RHOD2  RHOF2  ENSG000002718102  RND32  RND22  
    Selected SIMAP similar genes for RHOC using alignment to 8 protein entries:     RHOC_HUMAN (see all proteins) (see all similar genes):
    RHOA    RHOB    ARHA    RHOF    ARHE    RHOQ
    RND3    RHOD    RAC3    CDC42    RHOU    RND2
    ARHG    RHOG    RHOJ    RAC2    RHOV    RAC1

    Find genes that share paralogs with RHOC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOC (see all 201)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10594821,2
    C,F,A,H--113243879(-) CACTTC/TTGGCT 3 -- ut31 ese35Minor allele frequency- T:0.00MN NS NA 514
    rs10594111,2
    A--113243982(-) GCGCTC/TTGGGA 3 -- ut312Minor allele frequency- T:0.00MN NA 186
    rs756019921,2
    C--113244137(+) AGGGGG/TCATGT 3 -- ut312Minor allele frequency- T:0.07CSA WA 120
    rs1167292701,2
    C--113244155(+) GCCTTG/AGGGAT 3 -- ut311Minor allele frequency- A:0.01WA 118
    rs1130930651,2
    C,F--113244160(+) GGGGAT/GCTCAG 3 -- ut312Minor allele frequency- G:0.00NA 4550
    rs115389601,2
    C--113244187(-) CAAGCG/ATCGGA 6 /H /R mis1 ese31Minor allele frequency- A:0.00NA 4548
    rs1387561821,2
    C,F--113244301(+) GGTTCG/ACCATG 6 /A /V mis11Minor allele frequency- A:0.00NA 4552
    rs1475574111,2
    C--113244325(+) CAGACC/TGAACG 6 Q R mis10--------
    rs2020163251,2
    --113244326(+) AGACCG/TAACGG 6 R syn10--------
    rs1462456891,2
    C,F--113244330(+) CGAACG/AGGCTC 6 /P syn12Minor allele frequency- A:0.00NA EU 5829

    HapMap Linkage Disequilibrium report for RHOC (113243728 - 113250056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RHOC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2414426CNV Deletion18987734
    esv2716318CNV Deletion23290073
    esv2716329CNV Deletion23290073
    dgv332n71CNV Loss21882294
    esv27598CNV Loss19812545
    esv27061CNV Gain+Loss19812545
    essv21692CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOC
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165380    OMIM disorders: --

    3 diseases for RHOC:    
    About MalaCards
    non-small cell lung carcinoma    hepatocellular carcinoma    breast cancer


    Find genes that share disorders with RHOC           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RHOC gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory breast cancer 82.5 2 16187229 (1), 12479217 (1)
    metastasis 57.2 66 18980974 (7), 18794150 (4), 17549441 (4), 16899593 (3) (see all 24)
    tumors 42.1 69 18794150 (6), 12855641 (5), 12970882 (3), 11839578 (3) (see all 15)
    breast cancer 42 25 16187229 (5), 18478927 (5), 19421144 (4), 19815594 (2) (see all 10)
    cancer 38.9 10 19499974 (2), 15604264 (1), 17549441 (1), 19160018 (1) (see all 7)
    breast diseases 33.7 1 11839578 (1)
    breast carcinoma 32.5 5 11839578 (2), 15574779 (2), 19421144 (1)
    carcinoma ductal 31.2 1 11839578 (1)
    primary tumor 28.1 6 16899593 (2), 15312362 (2), 12808121 (1), 15867248 (1)
    carcinoma squamous cell 23.7 2 17896152 (2)

    Genetic Association Database (GAD): RHOC
    Human Genome Epidemiology (HuGE) Navigator: RHOC (4 documents)

    Export disorders for RHOC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOC gene, integrated from 10 sources (see all 170):
    (articles sorted by number of sources associating them with RHOC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coding sequence of human rho cDNAs clone 6 and clone 9. (PubMed id 3283705)1, 2, 3 Chardin P.... Tavitian A. (Nucleic Acids Res. 1988)
    2. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. (PubMed id 8816443)1, 2, 9 Leung T.... Lim L. (Mol. Cell. Biol. 1996)
    3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    5. The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer. (PubMed id 19094228)1, 4 Tapper W....Eccles D. (Breast Cancer Res. 2008)
    6. Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)1, 2 Kamijo K....Miki T. (Mol. Biol. Cell 2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Structural and mechanistic insights into the interaction between Rho and mammalian Dia. (PubMed id 15864301)1, 2 Rose R....Wittinghofer A. (Nature 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 389 HGNC: 669 AceView: RHOCandPPP2CZ Ensembl:ENSG00000155366 euGenes: HUgn389
    ECgene: RHOC H-InvDB: RHOC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RHOC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RHOC gene:
    Search GeneIP for patents involving RHOC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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