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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOC Gene

protein-coding   GIFtS: 66
GCID: GC01M113243

Ras Homolog Family Member C

(Previous names: ras homolog gene family, member C)
(Previous symbols: ARH9, ARHC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Homolog Family Member C1 2     Oncogene RHO H92
ARH91 2 3 5     RAS-Related Homolog 92
ARHC1 2 3 5     Rho-Related GTP-Binding Protein RhoC2
Ras Homolog Gene Family, Member C1 2     RhoC GTPase2
Rho CDNA Clone 92 3     Small GTP Binding Protein RhoC2
RHOH92 5     h93
H92     

External Ids:    HGNC: 6691   Entrez Gene: 3892   Ensembl: ENSG000001553667   OMIM: 1653805   UniProtKB: P081343   

Export aliases for RHOC gene to outside databases

Previous GC identifers: GC01M112544 GC01M112955 GC01M111103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOC Gene:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active
GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote
reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded
by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought
to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and
metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided
by RefSeq, Jul 2008)

GeneCards Summary for RHOC Gene: 
RHOC (ras homolog family member C) is a protein-coding gene. Diseases associated with RHOC include vesiculitis, and breast disease, and among its related super-pathways are Signaling by GPCR and Sema4D in semaphorin signaling. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134
Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal
adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin
contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial
epithelial cells

Gene Wiki entry for RHOC (RhoC) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOC gene promoter:
         AP-1   p53   ATF-2   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOC promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

RHOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M113243:  view genomic region     (about GC identifiers)

Start:
113,243,728 bp from pter      End:
113,250,056 bp from pter
Size:
6,329 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoC precursor  
Size: 193 amino acids; 22006 Da
Subunit: Interacts with RTKN (By similarity). Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cleavage furrow.
Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner
4 PDB 3D structures from and Proteopedia for RHOC:
1Z2C (3D)        2GCN (3D)        2GCO (3D)        2GCP (3D)    
Secondary accessions: B3KSW1 Q6ICN3

Explore the universe of human proteins at neXtProt for RHOC: NX_P08134

Explore proteomics data for RHOC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08134

  • RHOC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOC Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001036143.1  NP_001036144.1  NP_786886.1  

    ENSEMBL proteins: 
     ENSP00000345236   ENSP00000358656   ENSP00000285735   ENSP00000431392   ENSP00000358652  
     ENSP00000358651   ENSP00000358650   ENSP00000434310   ENSP00000358646   ENSP00000434877  
     ENSP00000390823   ENSP00000436240   ENSP00000399424   ENSP00000432209   ENSP00000395791  
     ENSP00000358647  
    Reactome Protein details: P08134
    Human Recombinant Protein Products for RHOC: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for RHOC
    OriGene MassSpec for RHOC 
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    Novus Biologicals RHOC Proteins
    Novus Biologicals RHOC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RHOC
    Cloud-Clone Corp. Proteins for RHOC 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    RHOC for ontologies           About GeneDecksing



    RHOC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RHOC
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RHOC 
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    Novus Biologicals RHOC Antibodies
    Abcam antibodies for RHOC
    Cloud-Clone Corp. Antibodies for RHOC 
    ThermoFisher Antibody for RHOC
    LSBio Antibodies in human, mouse, rat for RHOC 

    Assay Products for RHOC: 
    EMD Millipore Kits and Assays for the Analysis of RHOC
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    GenScript Custom Assay Services for RHOC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOC 
    Cloud-Clone Corp. CLIAs for RHOC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P08134

    ProtoNet protein and cluster: P08134

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOC_HUMAN, P08134
    Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal
    adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin
    contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial
    epithelial cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
         
    RHOC for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhoc):
     cellular  immune system  tumorigenesis 

    RHOC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rhoctm1Mak for RHOC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOC 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOC:
    hsa-mir-372 (MIRT005932), hsa-mir-138 (MIRT000495), hsa-mir-302b (MIRT005933)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOC
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOC (see all 26):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidRHOC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOC

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RHOC

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RHOC (see all 18)
    OriGene ORF clones in mouse, rat for RHOC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RHOC (NM_175744)
    Sino Biological Human cDNA Clone for RHOC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOC
    Sirion Biotech Customized lentivirus for stable overexpression of RHOC 
                         Customized lentivirus expression plasmids for stable overexpression of RHOC 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RHOC
    Search LifeMap BioReagents cell lines for RHOC
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHOC About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Sema4D in semaphorin signaling
    Sema4D in semaphorin signaling0.89
    Semaphorin interactions0.41
    Sema4D induced cell migration and growth-cone collapse0.89
    3Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    4Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    5Cell death signalling via NRAGE, NRIF and NADE
    G alpha (12/13) signalling events0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RHOC
        Wnt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for RHOC
        Cytoskeletal Signaling

    2 BioSystems Pathways for RHOC
        Spinal Cord Injury
    Signaling events mediated by PRL


    5/11        Reactome Pathways for RHOC (see all 11)
        GPCR downstream signaling
    Signaling by Rho GTPases
    Developmental Biology
    G alpha (12/13) signalling events
    Signaling by GPCR



    RHOC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/19 Interacting proteins for RHOC (P081342, 3 ENSP000002857354) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNKSR1Q969H42, 3, ENSP000003546094MINT-56517 I2D: score=2 STRING: ENSP00000354609
    ARHGAP1Q079603, ENSP000003104914I2D: score=4 STRING: ENSP00000310491
    CAV1Q031353, ENSP000003391914I2D: score=1 STRING: ENSP00000339191
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    LNX1Q8TBB13, ENSP000002639254I2D: score=1 STRING: ENSP00000263925
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IDA16236794
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007411axon guidance TAS--

    RHOC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOC for compounds           About GeneDecksing

    EMD Millipore small molecules for RHOC:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for RHOC

    Browse Tocris compounds for RHOC

    3 Novoseek inferred chemical compound relationships for RHOC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 57.9 2 19642867 (1)
    gtp 36.8 6 18377644 (2), 19642867 (1)
    vegf 18.4 3 14696649 (1), 15602803 (1)

    Search CenterWatch for drugs/clinical trials and news about RHOC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHOC gene (3 alternative transcripts): 
    NM_001042678.1  NM_001042679.1  NM_175744.4  

    Unigene Clusters for RHOC:

    Ras homolog family member C
    Hs.502659  [show with all ESTs], Hs.658289  [show with all ESTs]
    Unigene Representative Sequences: AK094474, BI000596
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000339083(uc001ecq.1 uc001ecr.1) ENST00000369642 ENST00000285735(uc009wgk.1)
    ENST00000468093 ENST00000369638 ENST00000369637 ENST00000369636 ENST00000473074
    ENST00000484280 ENST00000369632 ENST00000484054 ENST00000425265 ENST00000534717
    ENST00000436685 ENST00000528831 ENST00000414971 ENST00000478447 ENST00000527563

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOC
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOC (see all 26):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidRHOC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOC
    Clone
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    OriGene clones in human, mouse for RHOC (see all 18)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RHOC (NM_175744)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOC
    Sirion Biotech Customized lentivirus for stable overexpression of RHOC 
                         Customized lentivirus expression plasmids for stable overexpression of RHOC 
    Primer
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    OriGene qPCR primer pairs and template standards for RHOC
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOC

    Additional mRNA sequence: AF085893.1 

    24/40 DOTS entries (see all 40):

    DT.219329  DT.99926463  DT.92471967  DT.101986475  DT.95102696  DT.100673039  DT.121433304  DT.121433252 
    DT.95285439  DT.428367  DT.87079300  DT.100673034  DT.100673046  DT.121433212  DT.121433215  DT.100759962 
    DT.121433298  DT.92471807  DT.121433186  DT.95091621  DT.95103840  DT.99926455  DT.100716118  DT.121433164 

    24/712 AceView cDNA sequences (see all 712):

    BM841965 BQ893521 BQ639421 AI955324 BG749090 BM972377 CA454234 CR613350 
    BM460704 BM544586 BG168140 BE407130 AJ573147 CR450360 BM811142 CF126974 
    BX113316 BQ217273 BM984352 BE408828 AJ709108 AW390669 AX748024 BQ876561 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RHOC (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h
    SP1:                    -     -     -     -           -     -     -     -     -           -                                                                     
    SP2:                    -     -     -                 -     -     -     -     -           -                                                                     
    SP3:                                -     -           -     -     -     -     -           -                                                                     
    SP4:                                      -           -     -     -     -     -           -                                                                     
    SP5:                                                  -     -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for RHOC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOC expression in normal human tissues (normalized intensities)      RHOC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGGCT
    RHOC Expression
    About this image


    RHOC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Liver (Hepatobiliary System)
             Liver Bud

    See RHOC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOC

    SOURCE GeneReport for Unigene clusters: Hs.502659 Hs.658289
        SABiosciences Expression via Pathway-Focused PCR Array including RHOC: 
              Cell Motility in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOC gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhoc1 , 5 ras homolog gene family, member C1, 5 92.06(n)1
    100(a)1
      3 (45.86 cM)5
    118531  NM_007484.21  NP_031510.21 
     1047890115 
    chicken
    (Gallus gallus)
    Aves RHOC1 ras homolog gene family, member C 85.15(n)
    96.89(a)
      395869  NM_001029849.1  NP_001025020.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOC6
    --
    --
    95(a)
    85(a)
    1 ↔ 1
    possible ortholog
    4(128234464-128276561)
    2(68689850-68727433)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044696.12   -- 82.25(n)    BC044696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640152 similar to ras homolog gene family, member C 81.4(n)   394125  BC053200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rho11 CG8416-PA 72.16(n)
    86.7(a)
      36775  NM_057750.3  NP_477098.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rho-11 Protein RHO-1 70.49(n)
    84.9(a)
      178458  NM_070558.5  NP_502959.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHO16
    GTP-binding protein of the rho subfamily of Ras-li...
    65(a)
    1 → many
    XVI(875368-875997)


    ENSEMBL Gene Tree for RHOC (if available)
    TreeFam Gene Tree for RHOC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOC gene
    RHOB2  RHOA2  RND12  RHOD2  RHOF2  ENSG000002718102  RND22  RND32  
    18/83 SIMAP similar genes for RHOC using alignment to 8 protein entries:     RHOC_HUMAN (see all proteins) (see all similar genes):
    RHOA    RHOB    ARHA    RHOF    RHOQ    ARHE
    RND3    RHOD    RAC3    CDC42    RHOU    RND2
    RHOJ    ARHG    RHOG    RAC2    RHOV    RHOH

    RHOC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/201 SNPs in RHOC are shown (see all 201)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10594821,2
    C,F,A,H--113243879(-) CACTTC/TTGGCT 3 -- ut31 ese35Minor allele frequency- T:0.00MN NS NA 514
    rs10594111,2
    A--113243982(-) GCGCTC/TTGGGA 3 -- ut312Minor allele frequency- T:0.00MN NA 186
    rs756019921,2
    C--113244137(+) AGGGGG/TCATGT 3 -- ut312Minor allele frequency- T:0.07CSA WA 120
    rs1167292701,2
    C--113244155(+) GCCTTG/AGGGAT 3 -- ut311Minor allele frequency- A:0.01WA 118
    rs1130930651,2
    C,F--113244160(+) GGGGAT/GCTCAG 3 -- ut312Minor allele frequency- G:0.00NA 4550
    rs115389601,2
    C--113244187(-) CAAGCG/ATCGGA 6 /H /R mis1 ese31Minor allele frequency- A:0.00NA 4548
    rs1387561821,2
    C,F--113244301(+) GGTTCG/ACCATG 6 /A /V mis11Minor allele frequency- A:0.00NA 4552
    rs1475574111,2
    C--113244325(+) CAGACC/TGAACG 6 Q R mis10--------
    rs2020163251,2
    --113244326(+) AGACCG/TAACGG 6 R syn10--------
    rs1462456891,2
    C,F--113244330(+) CGAACG/AGGCTC 6 /P syn12Minor allele frequency- A:0.00NA EU 5829

    HapMap Linkage Disequilibrium report for RHOC (113243728 - 113250056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RHOC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2414426CNV Deletion18987734
    esv2716318CNV Deletion23290073
    esv2716329CNV Deletion23290073
    dgv332n71CNV Loss21882294
    esv27598CNV Loss19812545
    esv27061CNV Gain+Loss19812545
    essv21692CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165380    OMIM disorders: --

    20/30 diseases for RHOC (see all 30):    About MalaCards
    vesiculitis    breast disease    non-small cell lung carcinoma    clear cell renal cell carcinoma
    squamous cell carcinoma of the head and neck    pancreatic ductal adenocarcinoma    stomatitis    myotonic dystrophy
    hepatocellular carcinoma    renal cell carcinoma    esophageal squamous cell carcinoma    breast cancer
    squamous cell carcinoma    cervicitis    spasticity    prostate cancer
    cervical cancer    adenocarcinoma    melanoma    esophagitis


    RHOC for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for RHOC gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory breast cancer 82.5 2 16187229 (1), 12479217 (1)
    metastasis 57.2 66 18980974 (7), 18794150 (4), 17549441 (4), 16899593 (3) (see all 24)
    tumors 42.1 69 18794150 (6), 12855641 (5), 12970882 (3), 11839578 (3) (see all 15)
    breast cancer 42 25 16187229 (5), 18478927 (5), 19421144 (4), 19815594 (2) (see all 10)
    cancer 38.9 10 19499974 (2), 15604264 (1), 17549441 (1), 19160018 (1) (see all 7)
    breast diseases 33.7 1 11839578 (1)
    breast carcinoma 32.5 5 11839578 (2), 15574779 (2), 19421144 (1)
    carcinoma ductal 31.2 1 11839578 (1)
    primary tumor 28.1 6 16899593 (2), 15312362 (2), 12808121 (1), 15867248 (1)
    carcinoma squamous cell 23.7 2 17896152 (2)

    Genetic Association Database (GAD): RHOC
    Human Genome Epidemiology (HuGE) Navigator: RHOC (4 documents)

    Export disorders for RHOC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOC gene, integrated from 9 sources (see all 163):
    (articles sorted by number of sources associating them with RHOC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coding sequence of human rho cDNAs clone 6 and clone 9. (PubMed id 3283705)1, 2, 3 Chardin P.... Tavitian A. (1988)
    2. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. (PubMed id 8816443)1, 2, 9 Leung T.... Lim L. (1996)
    3. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    5. The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer. (PubMed id 19094228)1, 4 Tapper W....Eccles D. (2008)
    6. Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)1, 2 Kamijo K....Miki T. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Structural and mechanistic insights into the interaction between Rho and mammalian Dia. (PubMed id 15864301)1, 2 Rose R....Wittinghofer A. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 389 HGNC: 669 AceView: RHOCandPPP2CZ Ensembl:ENSG00000155366 euGenes: HUgn389
    ECgene: RHOC H-InvDB: RHOC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHOC gene:
    Search GeneIP for patents involving RHOC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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