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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RHOC Gene

protein-coding GIFtS: 63
GCID: GC01M113243

ras homolog family member C

(Previous names: ras homolog gene family, member C )
(Previous symbols: ARH9, ARHC)

Explore 35 diseases affiliated with
RHOC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ras Homolog Family Member C¹ ²		H9²
ARH9¹ ² ³ ⁵		Oncogene RHO H9²
ARHC¹ ² ³ ⁵		RAS-Related Homolog 9²
Ras Homolog Gene Family, Member C¹ ²		Rho-Related GTP-Binding Protein RhoC²
Rho CDNA Clone 9² ³		RhoC GTPase²
RHOH9² ⁵		Small GTP Binding Protein RhoC²
RhoC¹		H9²

External Ids:	HGNC: 669¹	Entrez Gene: 389²	Ensembl: ENSG00000155366⁷	OMIM: 165380⁵	UniProtKB: P08134³

Export aliases for RHOC gene to outside databases

Previous GC identifers: GC01M112544 GC01M112955 GC01M111103

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOC:

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active

GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote

reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by

this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be

important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis.

Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions

and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring

formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells

Gene Wiki entry for RHOC (RhoC)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHOC gene promoter:
AP-1 p53 ATF-2 GR-alpha c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHOC promoter sequence

Search SABiosciences Chromatin IP Primers for RHOC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1

RHOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOC gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M113243: view genomic region (about GC identifiers)

Start:	113,243,728 bp from pter	End:	113,250,056 bp from pter
Size:	6,329 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134 (See protein sequence)

Recommended Name: Rho-related GTP-binding protein RhoC precursor

Size: 193 amino acids; 22006 Da

Subunit: Interacts with RTKN (By similarity). Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cleavage furrow. Note=Translocates to

the equatorial region before furrow formation in a ECT2-dependent manner

4 PDB 3D structures from and Proteopedia for RHOC:

1Z2C (3D)

2GCN (3D)

2GCO (3D)

2GCP (3D)

Secondary accessions: B3KSW1 Q6ICN3

Explore the universe of human proteins at neXtProt for RHOC: NX_P08134

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08134

RHOC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001036143.1 NP_001036144.1 NP_786886.1

ENSEMBL proteins:

ENSP00000345236 ENSP00000358656 ENSP00000285735 ENSP00000431392 ENSP00000358652

ENSP00000358651 ENSP00000358650 ENSP00000434310 ENSP00000358646 ENSP00000434877

ENSP00000390823 ENSP00000436240 ENSP00000399424 ENSP00000432209 ENSP00000395791

ENSP00000358647

Reactome Protein details: P08134
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 3): RHOC OriGene Protein Over-expression Lysate (see all 4): RHOC OriGene Custom Protein Services for RHOC
	GenScript Custom Purified and Recombinant Proteins Services for RHOC
	Novus Biologicals RHOC Proteins Novus Biologicals RHOC Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RHOC
	Uscn Proteins for RHOC

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--

RHOC for ontologies About GeneDecksing

RHOC Antibody Products:

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	GenScript Custom Superior Antibodies Services for RHOC
	Novus Biologicals RHOC Antibodies
	Search for Antibodies for RHOC at Abcam
	Uscn Antibodies for RHOC
	ThermoFisher Antibodies for RHOC

Assay Products for RHOC:

	EMD Millipore Kits and Assays for the Analysis of RHOC
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RHOC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RHOC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RHOC for domains About GeneDecksing

3 InterPro domains/families:

IPR003578 Small_GTPase_Rho

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

Graphical View of Domain Structure for InterPro Entry P08134

ProtoNet protein and cluster: P08134

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134

Similarity: Belongs to the small GTPase superfamily. Rho family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RHOC_HUMAN, P08134

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions

and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring

formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells

miRNA Products:		miRTarBase miRNAs that target RHOC: hsa-mir-372 (MIRT005932), hsa-mir-138 (MIRT000495), hsa-mir-302b (MIRT005933)

		OriGene 3'-UTR Clone (see all 3): RHOC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOC
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOC (see all 26):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: RHOC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOC (see all 7) OriGene shRNA RFP: RHOC OriGene siRNA: RHOC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOC

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RHOC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOC (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOC (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RHOC (NM_175744)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RHOC
		Search LifeMap BioReagents cell lines for RHOC

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOC

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IMP	12761501
GO:0005515	protein binding	IPI	--
GO:0005525	GTP binding	IEA	--
GO:0019904	protein domain specific binding	--	--

RHOC for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Rhoc^tm1Mak for RHOC
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rhoc):

cellular

immune system

tumorigenesis

RHOC for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Sema4D in semaphorin signaling

	Sema4D in semaphorin signaling	1.00			Semaphorin interactions	0.44
	Sema4D induced cell migration and growth-cone collapse	0.83

Cell death signalling via NRAGE, NRIF and NADE

	G alpha (12/13) signalling events	0.39			Signaling by Rho GTPases	0.25
	Rho GTPase cycle	0.25

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for RHOC

Wnt Signaling Pathway

1 Cell Signaling Technology (CST) Pathway for RHOC

Cytoskeletal Signaling

1 BioSystems Pathway for RHOC

Signaling events mediated by PRL

5/11 Reactome Pathways for RHOC (see all 11)

	GPCR downstream signaling
	Signaling by Rho GTPases
	Developmental Biology
	G alpha (12/13) signalling events
	Signaling by GPCR

RHOC for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RHOC

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/19 Interacting proteins for RHOC (P08134^{2, 3} ENSP00000285735⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CNKSR1	Q969H4²^,³, ENSP00000354609⁴	MINT-56517 I2D: score=2 STRING: ENSP00000354609
ARHGAP1	Q07960³, ENSP00000310491⁴	I2D: score=4 STRING: ENSP00000310491
CAV1	Q03135³, ENSP00000339191⁴	I2D: score=1 STRING: ENSP00000339191
GH1	P01241³, ENSP00000312673⁴	I2D: score=1 STRING: ENSP00000312673
LNX1	Q8TBB1³, ENSP00000263925⁴	I2D: score=1 STRING: ENSP00000263925

About this table

Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	--	--
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007411	axon guidance	TAS	--
GO:0008064	regulation of actin polymerization or depolymerization	--	--

RHOC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RHOC for compounds About GeneDecksing

EMD Millipore small molecules for RHOC:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for RHOC

Browse Tocris compounds for RHOC
3 Novoseek chemical compound relationships for RHOC gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	57.9	2	19642867 (1)
gtp	36.8	6	18377644 (2), 19642867 (1)
vegf	18.4	3	14696649 (1), 15602803 (1)

Search CenterWatch for drugs/clinical trials and news about RHOC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RHOC gene (3 alternative transcripts):

NM_001042678.1 NM_001042679.1 NM_175744.4

Unigene Clusters for RHOC:

Ras homolog family member C

Hs.502659 [show with all ESTs], Hs.658289 [show with all ESTs]

Unigene Representative Sequences: AK094474, BI000596

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000339083(uc001ecq.1 uc001ecr.1) ENST00000369642 ENST00000285735(uc009wgk.1)

ENST00000468093 ENST00000369638 ENST00000369637 ENST00000369636 ENST00000473074

ENST00000484280 ENST00000369632 ENST00000484054 ENST00000425265 ENST00000534717

ENST00000436685 ENST00000528831 ENST00000414971 ENST00000478447 ENST00000527563

miRNA Products:		OriGene 3'-UTR Clone (see all 3): RHOC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOC
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOC (see all 26):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: RHOC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOC (see all 7) OriGene shRNA RFP: RHOC OriGene siRNA: RHOC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOC

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOC (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOC (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RHOC (NM_175744)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RHOC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOC

Additional cDNA sequence: AF085893.1

24/40 DOTS entries (see all 40):

DT.219329 DT.99926463 DT.92471967 DT.101986475 DT.95102696 DT.100673039 DT.121433304 DT.121433252

DT.95285439 DT.428367 DT.87079300 DT.100673034 DT.100673046 DT.121433186 DT.121433212 DT.121433215

DT.100759962 DT.121433298 DT.92471807 DT.95091621 DT.95103840 DT.99926455 DT.100716118 DT.121433164

24/712 AceView cDNA sequences (see all 712):

BM809288 BM716228 BI041057 CB107840 BM550619 AK093270 BG168140 AI167220

BM460704 BF309129 AL135003 BF698943 AI685637 AW512816 AW952909 BM558694

BU737640 BC007245 CR601446 BM854662 BE383738 BQ648340 BU521068 BU728160

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RHOC (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	·	11e	·	11f	·	11g	·	11h
SP1:							-		-		-		-				-		-		-		-		-				-
SP2:							-		-		-						-		-		-		-		-				-
SP3:											-		-				-		-		-		-		-				-
SP4:													-				-		-		-		-		-				-
SP5:																	-		-		-		-		-

ECgene alternative splicing isoforms for RHOC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHOC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAGGCT

About this image

RHOC expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Bud

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RHOC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHOC

SOURCE GeneReport for Unigene clusters: Hs.502659 Hs.658289

SABiosciences Expression via Pathway-Focused PCR Array including RHOC:

Cell Motility in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RHOC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOC

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOC gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RHOC¹	ras homolog gene family, member C	85.15(n) 96.89(a)		395869 NM_001029849.1 NP_001025020.1
lizard (Anolis carolinensis)	Reptilia	RHOC⁶	--	95(a)	1 ↔ 1	4(128238636-128244898)
African clawed frog (Xenopus laevis)	Amphibia	BC044696.1²	--	82.25(n)		BC044696.1
zebrafish (Danio rerio)	Actinopterygii	zgc64015²	similar to ras homolog gene family, member C	81.4(n)		394125 BC053200.1
fruit fly (Drosophila melanogaster)	Insecta	Rho1¹	CG8416-PA	72.16(n) 86.7(a)		36775 NM_057750.3 NP_477098.1
worm (Caenorhabditis elegans)	Secernentea	rho-1¹	Protein RHO-1	70.49(n) 84.9(a)		178458 NM_070558.5 NP_502959.1
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_ABR182W¹	ABR182Wp	62.81(n) 64.74(a)		4619240 NM_208483.1 NP_983130.1

ENSEMBL Gene Tree for RHOC (if available)
TreeFam Gene Tree for RHOC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RHOC gene

RHOB² RND1² RHOD² RHOA² RHOF² RND3²

18/85 SIMAP similar genes for RHOC using alignment to 8 protein entries: RHOC_HUMAN (see all proteins) (see all similar genes):

RHOA RHOB ARHA RHOF RHOQ ARHE

RND3 RHOD RAC3 CDC42 RHOU RND2

RHOJ ARHG RHOG RAC2 RHOV RHOH

RHOC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142632718^1,2	C,	--	113243313(+)	`TGGGGG/AAAGGG`	5	--	ds500¹ ut3¹		1		EU	573
rs75472514^1,2	F,	--	113243607(+)	`CAGGCA/CTGACC`	5	--	int¹ ds500¹		1		NA	120
rs57573777^1,2	C,	--	113243666(+)	`TAGACA/GGGGGG`	5	--	ds500¹ int¹		2		WA	120
rs188872130^1,2		--	113243668(+)	`GACAGA/GGGGCC`	5	--	ds500¹ int¹		0	--	--	--	--
rs145065621^1,2		--	113243696(+)	`GGACAC/TGAAAA`	5	--	ds500¹ int¹		0	--	--	--	--
rs1059482^1,2	C,F,A,H	--	113243879(-)	`CACTTC/TTGGCT`	3	--	ut3¹ ese³		5		MN NS NA	514
rs1059411^1,2	A	--	113243982(-)	`GCGCTC/TTGGGA`	3	--	ut3¹		2		MN NA	186
rs75601992^1,2	C,	--	113244137(+)	`AGGGGG/TCATGT`	3	--	ut3¹		2		CSA WA	120
rs116729270^1,2	C,	--	113244155(+)	`GCCTTG/AGGGAT`	3	--	ut3¹		1		WA	118
rs113093065^1,2	C,F	--	113244160(+)	`GGGGAT/GCTCAG`	3	--	ut3¹		2		NA	4550

HapMap Linkage Disequilibrium report for RHOC (113243728 - 113250056 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RHOC
4 CNVs: 2322 3306 64626 64617

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RHOC for disorders           About GeneDecksing

OMIM gene information: 165380    OMIM disorders: --

20/35 diseases for RHOC (see all 35):    About MalaCards

non-small cell lung carcinoma clear cell renal cell carcinoma squamous cell carcinoma inflammatory breast cancer

squamous cell carcinoma of the head and neck esophageal squamous cell carcinoma renal cell carcinoma myotonic dystrophy

pancreatic ductal adenocarcinoma carcinoma breast cancer hepatocellular carcinoma

stomatitis lung carcinoma breast carcinoma breast disease

cervicitis prostate cancer spasticity cervical carcinoma

10/16 Novoseek disease relationships for RHOC gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammatory breast cancer	82.5	2	16187229 (1), 12479217 (1)
metastasis	57.2	66	18980974 (7), 18794150 (4), 17549441 (4), 16899593 (3) (see all 24)
tumors	42.1	69	18794150 (6), 12855641 (5), 12970882 (3), 11839578 (3) (see all 15)
breast cancer	42	25	16187229 (5), 18478927 (5), 19421144 (4), 19815594 (2) (see all 10)
cancer	38.9	10	19499974 (2), 15604264 (1), 17549441 (1), 19160018 (1) (see all 7)
breast diseases	33.7	1	11839578 (1)
breast carcinoma	32.5	5	11839578 (2), 15574779 (2), 19421144 (1)
carcinoma ductal	31.2	1	11839578 (1)
primary tumor	28.1	6	16899593 (2), 15312362 (2), 12808121 (1), 15867248 (1)
carcinoma squamous cell	23.7	2	17896152 (2)

Human Genome Epidemiology (HuGE) Navigator: RHOC (4 documents)

Export disorders for RHOC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RHOC gene, integrated from 9 sources (see all 152):
(articles sorted by number of sources associating them with RHOC)

Utopia: connect your pdf to the dynamic
world of online information

Coding sequence of human rho cDNAs clone 6 and clone 9. (PubMed id 3283705)^{1, 2, 3} Chardin P.... Tavitian A. (1988)
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. (PubMed id 8816443)^{1, 2, 9} Leung T.... Lim L. (1996)
Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)^{1, 2} Kamijo K....Miki T. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Structural and mechanistic insights into the interaction between Rho and mammalian Dia. (PubMed id 15864301)^{1, 2} Rose R....Wittinghofer A. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. (PubMed id 11546812)^{1, 2} Diviani D.... Scott J.D. (2001)
RhoC is essential for the metastasis of gastric cancer. (PubMed id 17549441)^{1, 9} Liu N....Fan D. (2007)
Inhibition of invasion and metastasis of hepatocellular carcinoma cells via targeting RhoC in vitro and in vivo. (PubMed id 18980974)^{1, 9} Wang W....Yang L. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 389	HGNC: 669	AceView: RHOCandPPP2CZ	Ensembl:ENSG00000155366	euGenes: HUgn389
ECgene: RHOC	H-InvDB: RHOC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RHOC	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RHOC	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RHOC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RHOC gene:
Search GeneIP for patents involving RHOC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
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ras homolog family member C

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ras homolog family member C

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