Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RHOBTB3 Gene

protein-coding   GIFtS: 56
GCID: GC05P095092

Rho-Related BTB Domain Containing 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Rho-Related BTB Domain Containing 31 2
KIAA08783 5
Rho-Related BTB Domain-Containing Protein 32
EC 3.6.1.-3

External Ids:    HGNC: 187571   Entrez Gene: 228362   Ensembl: ENSG000001642927   OMIM: 6073535   UniProtKB: O949553   

Export aliases for RHOBTB3 gene to outside databases

Previous GC identifers: GC05P094324 GC05P095531 GC05P095082 GC05P095141 GC05P090257


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RHOBTB3 Gene:
RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on
RHOBTBs, see RHOBTB1 (MIM 607351).(supplied by OMIM, Apr 2004)

GeneCards Summary for RHOBTB3 Gene:
RHOBTB3 (Rho-related BTB domain containing 3) is a protein-coding gene. Diseases associated with RHOBTB3 include atherosclerosis. GO annotations related to this gene include GTP binding and Rab GTPase binding.

UniProtKB/Swiss-Prot: RHBT3_HUMAN, O94955
Function: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at
the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient
docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase
activity due to autoinhibition, which is relieved by Rab9

Gene Wiki entry for RHOBTB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOBTB3 gene promoter:
         Pbx1a   FOXO3   HNF-1A   FOXO3b   POU2F1   Nkx6-1   HNF-1   POU2F1a   FOXO3a   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOBTB3 promoter sequence
   Search Chromatin IP Primers for RHOBTB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOBTB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

RHOBTB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOBTB3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P095092:  view genomic region     (about GC identifiers)

Start:
95,049,226 bp from pter      End:
95,160,087 bp from pter
Size:
110,862 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RHBT3_HUMAN, O94955 (See protein sequence)
Recommended Name: Rho-related BTB domain-containing protein 3  
Size: 611 amino acids; 69413 Da
Subunit: Interacts with RAB9A and RAB9B (at lower level compared to RAB9A-binding). Interacts with M6PRBP1/TIP47
Sequence caution: Sequence=BAA74901.2; Type=Erroneous initiation;
Secondary accessions: A0PJA4 A8K1W9 Q8IW06

Explore the universe of human proteins at neXtProt for RHOBTB3: NX_O94955

Explore proteomics data for RHOBTB3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys105, Lys592
  • Modification sites at PhosphoSitePlus

  • See RHOBTB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055714.3  
    ENSEMBL proteins: 
     ENSP00000423688   ENSP00000426479   ENSP00000369318   ENSP00000423652   ENSP00000421875  
     ENSP00000422360   ENSP00000424844   ENSP00000426390   ENSP00000425342   ENSP00000424700  

    RHOBTB3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RHOBTB3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RHOBTB3
    GenScript Custom Purified and Recombinant Proteins Services for RHOBTB3
    Novus Biologicals RHOBTB3 Proteins
    Novus Biologicals RHOBTB3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHOBTB3

    RHOBTB3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RHOBTB3
    OriGene Custom Antibody Services for RHOBTB3
    Novus Biologicals RHOBTB3 Antibodies
    Abcam antibodies for RHOBTB3
    Cloud-Clone Corp. Antibodies for RHOBTB3
    Search ThermoFisher Antibodies for RHOBTB3
    LSBio Antibodies in human, mouse, rat for RHOBTB3

    RHOBTB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RHOBTB3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RHOBTB3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOBTB3
    Cloud-Clone Corp. CLIAs for RHOBTB3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BTBD: BTB/POZ domain containing

    5 InterPro protein domains:
     IPR001806 Small_GTPase
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR027417 P-loop_NTPase
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O94955

    ProtoNet protein and cluster: O94955

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: RHBT3_HUMAN, O94955
    Domain: Although predicted to be a GTP-binding protein because of the presence of a Rho-like region, binds and
    hydrolyzes ATP. In contrast to Rho-like proteins, the conserved Asp residue in position 138 in the G4 region is
    replaced by an Asn, decreasing the ability to bind GTP
    Similarity: Contains 2 BTB (POZ) domains


    RHOBTB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHBT3_HUMAN, O94955
    Function: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at
    the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient
    docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase
    activity due to autoinhibition, which is relieved by Rab9
    Biophysicochemical properties: Kinetic parameters: KM=48 uM for ATP;

         Enzyme Number (IUBMB): EC 3.6.1.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19490898
    GO:0005524ATP binding IDA19490898
    GO:0005525GTP binding IEA--
    GO:0016887ATPase activity IDA19490898
    GO:0017137Rab GTPase binding IPI19490898
         
    RHOBTB3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RHOBTB3:
     Increased cell death HMECs cel  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhobtb3):
     behavior/neurological  craniofacial  growth/size/body  limbs/digits/tail  mortality/aging 
     skeleton 

    RHOBTB3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHOBTB3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHOBTB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOBTB3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOBTB3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOBTB3:
    hsa-mir-98-5p (MIRT027831), hsa-mir-215-5p (MIRT024323), hsa-mir-192-5p (MIRT026931)

    Block miRNA regulation of human, mouse, rat RHOBTB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOBTB3 (see all 48):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548k hsa-miR-578 hsa-miR-548l hsa-miR-183* hsa-miR-208b hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmidRHOBTB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RHOBTB3
    Predesigned siRNA for gene silencing in human, mouse, rat RHOBTB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOBTB3

    Clone
    Products:
         
    OriGene clones in human, mouse for RHOBTB3 (see all 6)
    OriGene ORF clones in mouse, rat for RHOBTB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOBTB3 (NM_014899)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOBTB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOBTB3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RHOBTB3
    Browse ESI BIO Cell Lines and PureStem Progenitors for RHOBTB3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RHBT3_HUMAN, O94955: Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol2
    endoplasmic reticulum1
    endosome1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--

    RHOBTB3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including RHOBTB3: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RHOBTB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for RHOBTB3 (O949551, 3 ENSP000003693184) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLIN3O606643, ENSP000002219574I2D: score=1 STRING: ENSP00000221957
    RAB9BQ9NP903, ENSP000002432984I2D: score=1 STRING: ENSP00000243298
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    HTR7ENSP000003379494STRING: ENSP00000337949
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA19490898
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0042147retrograde transport, endosome to Golgi IMP19490898

    RHOBTB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOBTB3 (RHBT3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RHOBTB3 gene: 
    NM_014899.3  

    Unigene Cluster for RHOBTB3:

    Rho-related BTB domain containing 3
    Hs.445030  [show with all ESTs]
    Unigene Representative Sequence: NM_014899
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515852 ENST00000510226 ENST00000504949(uc003klk.1) ENST00000506959
    ENST00000506817(uc003kll.3) ENST00000379982(uc003klm.3) ENST00000512878
    ENST00000510623 ENST00000502541 ENST00000504179 ENST00000510313 ENST00000507186
    ENST00000511558 ENST00000503737 ENST00000513091 ENST00000514198
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RHOBTB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOBTB3 (see all 48):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548k hsa-miR-578 hsa-miR-548l hsa-miR-183* hsa-miR-208b hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmidRHOBTB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RHOBTB3
    Predesigned siRNA for gene silencing in human, mouse, rat RHOBTB3
    Clone
    Products:
         
    OriGene clones in human, mouse for RHOBTB3 (see all 6)
    OriGene ORF clones in mouse, rat for RHOBTB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOBTB3 (NM_014899)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOBTB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOBTB3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOBTB3
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOBTB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOBTB3
      QuantiTect SYBR Green Assays in human, mouse, rat RHOBTB3
      QuantiFast Probe-based Assays in human, mouse, rat RHOBTB3

    Additional mRNA sequence: 

    AB020685.1 AF131794.1 AK023621.1 AK057894.1 AK290034.1 BC013169.1 BC020231.1 BC041337.2 
    BC047884.1 

    Selected DOTS entries (see all 33):

    DT.100778673  DT.448440  DT.95232057  DT.446835  DT.100817928  DT.100817936  DT.203087  DT.92437794 
    DT.97764833  DT.101968678  DT.86846931  DT.120837932  DT.100817935  DT.100817937  DT.120837883  DT.120837975 
    DT.40266736  DT.120837936  DT.405644  DT.95271728  DT.100817930  DT.100817932  DT.100817933  DT.120837858 

    Selected AceView cDNA sequences (see all 453):

    BE219241 BU689595 BU077428 CA423164 BQ893734 BM667134 H89899 BC020231 
    CB159287 BG619889 BU619786 AU102654 AA708735 BQ010594 CA412023 AI921481 
    CA436646 AA150218 BU783221 CD516274 CR622454 AA037718 BX117536 AI624130 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB3 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:                                                                                            -                           
    SP2:                                                                                            -           -               
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                            -                           


    ECgene alternative splicing isoforms for RHOBTB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RHOBTB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCTTCAT
    RHOBTB3 Expression
    About this image


    RHOBTB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     NULL (Uncategorized)    fully expand to see all 4 entries
             Definitive endoderm-like cells
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Neural Tube (Nervous System)
             Telencephalon
    RHOBTB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOBTB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445030

    UniProtKB/Swiss-Prot: RHBT3_HUMAN, O94955
    Tissue specificity: Ubiquitous. Highly expressed in neural and cardiac tissues, pancreas, placenta and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including RHOBTB3: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHOBTB3
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOBTB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOBTB3
    QuantiTect SYBR Green Assays in human, mouse, rat RHOBTB3
    QuantiFast Probe-based Assays in human, mouse, rat RHOBTB3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for RHOBTB3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhobtb31 , 5 Rho-related BTB domain containing 31, 5 89.8(n)1
    95.74(a)1
      13 (40.95 cM)5
    732961  NM_028493.21  NP_082769.11 
     758695375 
    chicken
    (Gallus gallus)
    Aves RHOBTB31 Rho-related BTB domain containing 3 72.3(n)
    72.52(a)
      431569  XM_004949383.1  XP_004949440.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOBTB36
    Rho-related BTB domain containing 3
    75(a)
    1 ↔ 1
    2(25968458-26010080)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rhobtb31 Rho-related BTB domain containing 3 63.1(n)
    56.86(a)
      100485375  XM_002933441.2  XP_002933487.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-6b12.51 si:dkey-6b12.5 54.05(n)
    49.16(a)
      562804  XM_686178.6  XP_691270.6 


    ENSEMBL Gene Tree for RHOBTB3 (if available)
    TreeFam Gene Tree for RHOBTB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RHOBTB3 gene
    1 SIMAP similar gene for RHOBTB3 using alignment to 10 protein entries:     RHBT3_HUMAN (see all proteins):
    BTBD9

    RHOBTB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RHOBTB3 (see all 1272)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1410519421,2
    Cuntested195091233(+) AAGATC/TGTTCT 2 I syn10--------
    rs1895994881,2
    --95064851(+) TGCCTA/GTGGAG 1 -- us2k10--------
    rs1426392861,2
    C--95064854(+) CTATGA/GAGTAG 1 -- us2k10--------
    rs1808560241,2
    --95065235(+) GTACAC/TGCTCT 1 -- us2k10--------
    rs1853101651,2
    C--95065293(+) AGTACA/GAACTA 1 -- us2k10--------
    rs1509869231,2
    --95065321(+) ACAGAC/TCTCTG 1 -- us2k10--------
    rs1412723591,2
    C--95065374(+) ACAACA/GCCCCC 1 -- us2k10--------
    rs1900710991,2
    --95065379(+) GCCCCC/GTTTTC 1 -- us2k10--------
    rs1834509371,2
    --95065653(+) TTTCCA/GGAAAA 1 -- us2k10--------
    rs1450661431,2
    C--95065744(+) TTCTAC/GAGACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHOBTB3 (95049226 - 95160087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RHOBTB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830409CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOBTB3
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOBTB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607353    OMIM disorders: --

    1 disease for RHOBTB3:    
    About MalaCards
    atherosclerosis


    RHOBTB3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RHOBTB3
    Human Genome Epidemiology (HuGE) Navigator: RHOBTB3 (1 document)

    Export disorders for RHOBTB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RHOBTB3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with RHOBTB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    2. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. (PubMed id 19490898)1, 2 Espinosa E.J.... Pfeffer S.R. (Cell 2009)
    3. Evolution of the Rho family of ras-like GTPases in eukaryotes. (PubMed id 17035353)1, 3 Boureux A....Fort P. (Mol. Biol. Evol. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. (PubMed id 12426103)1, 2 Ramos S.... Rivero F. (Gene 2002)
    7. The Dictyostelium discoideum family of Rho-related proteins. (PubMed id 11222756)1, 3 Rivero F....Noegel A.A. (Nucleic Acids Res. 2001)
    8. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    9. Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. (PubMed id 24145166)1 Lu A. and Pfeffer S.R. (J. Cell Biol. 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22836 HGNC: 18757 AceView: RHOBTB3 Ensembl:ENSG00000164292 euGenes: HUgn22836
    ECgene: RHOBTB3 H-InvDB: RHOBTB3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0878

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RHOBTB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RHOBTB3 gene:
    Search GeneIP for patents involving RHOBTB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RHOBTB3   OriGene RNAi products in human, mouse, rat for RHOBTB3  
     OriGene qPCR primer pairs and template standards for RHOBTB3   OriGene Protein Over-expression Lysate for RHOBTB3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RHOBTB3  
     OriGene qSTAR qPCR primer pairs in human, mouse for RHOBTB3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RHOBTB3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RHOBTB3   OriGene Custom Protein Services for RHOBTB3  

     
     
     Block miRNA regulation of human, mouse, rat RHOBTB3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RHOBTB3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOBTB3 Predesigned siRNA for gene silencing in human, mouse, rat RHOBTB3
     QuantiFast Probe-based Assays in human, mouse, rat RHOBTB3 QuantiTect SYBR Green Assays in human, mouse, rat RHOBTB3
     PCR Arrays including human, mouse, rat RHOBTB3 Search Chromatin IP Primers for RHOBTB3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOBTB3  Search GeneGlobe Interaction Network for RHOBTB3
     Regulatory tfbs in RHOBTB3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RHOBTB3 GenScript cDNA clones with any tag delivered in your preferred vector for RHOBTB3
     GenScript Custom Assay Services for RHOBTB3 GenScript Custom overexpressing Cell Line Services for RHOBTB3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RHOBTB3 (RHBT3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RHOBTB3 antibodies
     RHOBTB3 proteins
     RHOBTB3 lysates
     Antibodies for RHOBTB3
     See all of Abcam's Antibodies, Kits and Proteins for RHOBTB3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RHOBTB3
     Antibodies for RHOBTB3
     ELISAs for RHOBTB3
     CLIAs for RHOBTB3



     Browse ESI BIO Cell Lines and PureStem Progenitors for RHOBTB3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB3
     SwitchGear 3'UTR luciferase reporter plasmids for RHOBTB3
     SwitchGear Promoter luciferase reporter plasmids for RHOBTB3
     Search ThermoFisher Antibodies for RHOBTB3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOBTB3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHOBTB3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHOBTB3
     LSBio Antibodies in human, mouse, rat for RHOBTB3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RHOBTB3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4