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Aliases for RHOBTB3 Gene

Aliases for RHOBTB3 Gene

  • Rho-Related BTB Domain Containing 3 2 3
  • KIAA0878 4 6
  • EC 3.6.1.- 4

External Ids for RHOBTB3 Gene

Previous GeneCards Identifiers for RHOBTB3 Gene

  • GC05P094324
  • GC05P095531
  • GC05P095082
  • GC05P095141
  • GC05P095092
  • GC05P090257

Summaries for RHOBTB3 Gene

Entrez Gene Summary for RHOBTB3 Gene

  • RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM, Apr 2004]

GeneCards Summary for RHOBTB3 Gene

RHOBTB3 (Rho-Related BTB Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include GTP binding and Rab GTPase binding.

UniProtKB/Swiss-Prot for RHOBTB3 Gene

  • Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.

Gene Wiki entry for RHOBTB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOBTB3 Gene

Genomics for RHOBTB3 Gene

Regulatory Elements for RHOBTB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RHOBTB3 Gene

Start:
95,713,522 bp from pter
End:
95,824,383 bp from pter
Size:
110,862 bases
Orientation:
Plus strand

Genomic View for RHOBTB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOBTB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOBTB3 Gene

Proteins for RHOBTB3 Gene

  • Protein details for RHOBTB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94955-RHBT3_HUMAN
    Recommended name:
    Rho-related BTB domain-containing protein 3
    Protein Accession:
    O94955
    Secondary Accessions:
    • A0PJA4
    • A8K1W9
    • Q8IW06

    Protein attributes for RHOBTB3 Gene

    Size:
    611 amino acids
    Molecular mass:
    69413 Da
    Quaternary structure:
    • Interacts with RAB9A and RAB9B (at lower level compared to RAB9A-binding). Interacts with M6PRBP1/TIP47.
    SequenceCaution:
    • Sequence=BAA74901.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RHOBTB3 Gene

Proteomics data for RHOBTB3 Gene at MOPED

Post-translational modifications for RHOBTB3 Gene

  • Ubiquitination at Lys105 and Lys592
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RHOBTB3 Gene

Domains for RHOBTB3 Gene

Gene Families for RHOBTB3 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for RHOBTB3 Gene

Suggested Antigen Peptide Sequences for RHOBTB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94955

UniProtKB/Swiss-Prot:

RHBT3_HUMAN :
  • O94955
Domain:
  • Although predicted to be a GTP-binding protein because of the presence of a Rho-like region, binds and hydrolyzes ATP. In contrast to Rho-like proteins, the conserved Asp residue in position 138 in the G4 region is replaced by an Asn, decreasing the ability to bind GTP
  • Contains 2 BTB (POZ) domains.
genes like me logo Genes that share domains with RHOBTB3: view

Function for RHOBTB3 Gene

Molecular function for RHOBTB3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=48 uM for ATP {ECO:0000269 PubMed:19490898};
UniProtKB/Swiss-Prot Function: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.

Enzyme Numbers (IUBMB) for RHOBTB3 Gene

Gene Ontology (GO) - Molecular Function for RHOBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19490898
GO:0005524 ATP binding IDA 19490898
GO:0005525 GTP binding IEA --
GO:0016887 ATPase activity IDA 19490898
GO:0017137 Rab GTPase binding IPI 19490898
genes like me logo Genes that share ontologies with RHOBTB3: view
genes like me logo Genes that share phenotypes with RHOBTB3: view

Animal Model Products

CRISPR Products

miRNA for RHOBTB3 Gene

miRTarBase miRNAs that target RHOBTB3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RHOBTB3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RHOBTB3 Gene

Localization for RHOBTB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOBTB3 Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOBTB3 Gene COMPARTMENTS Subcellular localization image for RHOBTB3 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
endoplasmic reticulum 1
endosome 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RHOBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with RHOBTB3: view

Pathways for RHOBTB3 Gene

SuperPathways for RHOBTB3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RHOBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008152 metabolic process IEA --
GO:0042147 retrograde transport, endosome to Golgi IMP 19490898
genes like me logo Genes that share ontologies with RHOBTB3: view

No data available for Pathways by source for RHOBTB3 Gene

Transcripts for RHOBTB3 Gene

Unigene Clusters for RHOBTB3 Gene

Rho-related BTB domain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RHOBTB3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for RHOBTB3 Gene

GeneLoc Exon Structure for
RHOBTB3
ECgene alternative splicing isoforms for
RHOBTB3

Expression for RHOBTB3 Gene

mRNA expression in normal human tissues for RHOBTB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOBTB3 Gene

SOURCE GeneReport for Unigene cluster for RHOBTB3 Gene Hs.445030

mRNA Expression by UniProt/SwissProt for RHOBTB3 Gene

O94955-RHBT3_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in neural and cardiac tissues, pancreas, placenta and testis.
genes like me logo Genes that share expressions with RHOBTB3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RHOBTB3 Gene

Orthologs for RHOBTB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RHOBTB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOBTB3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOBTB3 35
  • 91.33 (n)
  • 95.91 (a)
RHOBTB3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOBTB3 35
  • 93.01 (n)
  • 96.19 (a)
RHOBTB3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhobtb3 35
  • 89.8 (n)
  • 95.74 (a)
Rhobtb3 16
Rhobtb3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOBTB3 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOBTB3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhobtb3 35
  • 89.63 (n)
  • 96.07 (a)
chicken
(Gallus gallus)
Aves RHOBTB3 35
  • 72.3 (n)
  • 72.52 (a)
RHOBTB3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOBTB3 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhobtb3 35
  • 63.1 (n)
  • 56.86 (a)
zebrafish
(Danio rerio)
Actinopterygii RHOBTB3 36
  • 46 (a)
OneToOne
si:dkey-6b12.5 35
  • 54.05 (n)
  • 49.16 (a)
Species with no ortholog for RHOBTB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOBTB3 Gene

ENSEMBL:
Gene Tree for RHOBTB3 (if available)
TreeFam:
Gene Tree for RHOBTB3 (if available)

Paralogs for RHOBTB3 Gene

Selected SIMAP similar genes for RHOBTB3 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with RHOBTB3: view

No data available for Paralogs for RHOBTB3 Gene

Variants for RHOBTB3 Gene

Sequence variations from dbSNP and Humsavar for RHOBTB3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6697 -- 95,793,352(-) TTTTG(C/T)TCCCT utr-variant-3-prime
rs6815 -- 95,795,588(-) CTCCA(C/T)ACCAA utr-variant-3-prime
rs7622 -- 95,795,697(+) AAATT(A/G)GTGTT utr-variant-3-prime
rs12089 -- 95,795,637(-) GTCAC(A/T)CACAC utr-variant-3-prime
rs12351 -- 95,793,547(+) TCTAT(G/T)AAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RHOBTB3 Gene

Variant ID Type Subtype PubMed ID
nsv830409 CNV Gain 17160897

Relevant External Links for RHOBTB3 Gene

HapMap Linkage Disequilibrium report
RHOBTB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOBTB3 Gene

Disorders for RHOBTB3 Gene

Relevant External Links for RHOBTB3

Genetic Association Database (GAD)
RHOBTB3
Human Genome Epidemiology (HuGE) Navigator
RHOBTB3
genes like me logo Genes that share disorders with RHOBTB3: view

No data available for UniProtKB/Swiss-Prot for RHOBTB3 Gene

Publications for RHOBTB3 Gene

  1. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. (PMID: 19490898) Espinosa E.J. … Pfeffer S.R. (Cell 2009) 3 4
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 48
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. The Dictyostelium discoideum family of Rho-related proteins. (PMID: 11222756) Rivero F. … Noegel A.A. (Nucleic Acids Res. 2001) 2 3
  5. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. (PMID: 12426103) Ramos S. … Rivero F. (Gene 2002) 3 4

Products for RHOBTB3 Gene

  • antibodies-online proteins for RHOBTB3
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  • antibodies-online kits for RHOBTB3

Sources for RHOBTB3 Gene

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