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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOBTB3 Gene

protein-coding   GIFtS: 54
GCID: GC05P095092

Rho-Related BTB Domain Containing 3
  Search for RHOBTB3
at
MalaCards
 

Aliases
for RHOBTB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Rho-Related BTB Domain Containing 31 2
KIAA08783 5
Rho-Related BTB Domain-Containing Protein 32
EC 3.6.1.-3

External Ids:    HGNC: 187571   Entrez Gene: 228362   Ensembl: ENSG000001642927   OMIM: 6073535   UniProtKB: O949553   

Export aliases for RHOBTB3 gene to outside databases

Previous GC identifers: GC05P094324 GC05P095531 GC05P095082 GC05P095141 GC05P090257


Summaries
for RHOBTB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RHOBTB3 Gene:
RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on
RHOBTBs, see RHOBTB1 (MIM 607351).(supplied by OMIM, Apr 2004)

GeneCards Summary for RHOBTB3 Gene: 
RHOBTB3 (Rho-related BTB domain containing 3) is a protein-coding gene. GO annotations related to this gene include GTP binding and Rab GTPase binding.

UniProtKB/Swiss-Prot: RHBT3_HUMAN, O94955
Function: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at
the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient
docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase
activity due to autoinhibition, which is relieved by Rab9

Gene Wiki entry for RHOBTB3 Gene


Genomic Views
for RHOBTB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOBTB3 gene promoter:
         Pbx1a   FOXO3   HNF-1A   FOXO3b   POU2F1   Nkx6-1   HNF-1   POU2F1a   FOXO3a   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHOBTB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOBTB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOBTB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

RHOBTB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOBTB3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P095092:  view genomic region     (about GC identifiers)

Start:
 95,049,226 bp from pter      End:
 95,160,087 bp from pter
Size:
 110,862 bases      Orientation:
 plus strand

Proteins
for RHOBTB3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: RHBT3_HUMAN, O94955 (See protein sequence)
Recommended Name: Rho-related BTB domain-containing protein 3  
Size: 611 amino acids; 69413 Da
Subunit: Interacts with RAB9A and RAB9B (at lower level compared to RAB9A-binding). Interacts with M6PRBP1/TIP47
Subcellular location: Golgi apparatus
Sequence caution: Sequence=BAA74901.2; Type=Erroneous initiation;
Secondary accessions: A0PJA4 A8K1W9 Q8IW06

Explore the universe of human proteins at neXtProt for RHOBTB3: NX_O94955

Explore proteomics data for RHOBTB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94955

    • RHOBTB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOBTB3 Protein Expression
    REFSEQ proteins: NP_055714.3  
    ENSEMBL proteins: 
     ENSP00000423688   ENSP00000426479   ENSP00000369318   ENSP00000423652   ENSP00000421875  
     ENSP00000422360   ENSP00000424844   ENSP00000426390   ENSP00000425342   ENSP00000424700  

    Human Recombinant Protein Products for RHOBTB3: 
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    Novus Biologicals RHOBTB3 Proteins
    Novus Biologicals RHOBTB3 Lysates
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHOBTB3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--

    RHOBTB3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RHOBTB3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    BTBD: BTB/POZ domain containing

    5 InterPro protein domains:
     IPR001806 Small_GTPase
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR027417 P-loop_NTPase
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O94955

    ProtoNet protein and cluster: O94955

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: RHBT3_HUMAN, O94955
    Domain: Although predicted to be a GTP-binding protein because of the presence of a Rho-like region, binds and
    hydrolyzes ATP. In contrast to Rho-like proteins, the conserved Asp residue in position 138 in the G4 region is
    replaced by an Asn, decreasing the ability to bind GTP
    Similarity: Contains 2 BTB (POZ) domains


    RHOBTB3 for domains           About GeneDecksing


    Function
    for RHOBTB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHBT3_HUMAN, O94955
    Function: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at
    the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient
    docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase
    activity due to autoinhibition, which is relieved by Rab9
    Biophysicochemical properties: Kinetic parameters: KM=48 uM for ATP;

         Enzyme Number (IUBMB): EC 3.6.1.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19490898
    GO:0005524ATP binding IDA19490898
    GO:0005525GTP binding IEA--
    GO:0016887ATPase activity IDA19490898
    GO:0017137Rab GTPase binding IPI19490898
         
    RHOBTB3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RHOBTB3:
     Increased cell death HMECs cel  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rhobtb3):
     behavior/neurological  craniofacial  growth/size  limbs/digits/tail  mortality/aging 
     skeleton 

    RHOBTB3 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmid: RHOBTB3 3' UTR sequence
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    Pathways & Interactions
    for RHOBTB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHOBTB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for RHOBTB3 (O949551, 3 ENSP000003693184) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLIN3O606643, ENSP000002219574I2D: score=1 STRING: ENSP00000221957
    RAB9BQ9NP903, ENSP000002432984I2D: score=1 STRING: ENSP00000243298
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    HTR7ENSP000003379494STRING: ENSP00000337949
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA19490898
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0042147retrograde transport, endosome to Golgi IMP19490898

    RHOBTB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RHOBTB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOBTB3 (RHBT3)

    Search CenterWatch for drugs/clinical trials and news about RHOBTB3 / RHBT3

    Transcripts
    for RHOBTB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RHOBTB3 gene: 
    NM_014899.3  

    Unigene Cluster for RHOBTB3:

    Rho-related BTB domain containing 3
    Hs.445030  [show with all ESTs]
    Unigene Representative Sequence: NM_014899
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515852 ENST00000510226 ENST00000504949(uc003klk.1) ENST00000506959
    ENST00000506817(uc003kll.3) ENST00000379982(uc003klm.3) ENST00000512878
    ENST00000510623 ENST00000502541 ENST00000504179 ENST00000510313 ENST00000507186
    ENST00000511558 ENST00000503737 ENST00000513091 ENST00000514198
    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOBTB3 (see all 48):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548k hsa-miR-578 hsa-miR-548l hsa-miR-183* hsa-miR-208b hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmid: RHOBTB3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB020685.1 AF131794.1 AK023621.1 AK057894.1 AK290034.1 BC013169.1 BC020231.1 BC041337.2 
    BC047884.1 

    24/33 DOTS entries (see all 33):

    DT.100778673  DT.448440  DT.95232057  DT.446835  DT.100817928  DT.100817936  DT.203087  DT.92437794 
    DT.97764833  DT.101968678  DT.86846931  DT.120837932  DT.100817935  DT.100817937  DT.120837883  DT.120837975 
    DT.40266736  DT.120837936  DT.405644  DT.95271728  DT.100817930  DT.100817932  DT.100817933  DT.120837858 

    24/453 AceView cDNA sequences (see all 453):

    BU726453 AA620627 H21805 AU098468 BG614097 CA313046 BU783471 BQ893734 
    AU102654 CA441840 BU631944 AW007588 AA131746 AI188927 BG572778 BQ014487 
    AA725004 BU783221 BU077651 CB243707 BM721787 BM991473 AW675151 AA218760 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB3 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:                                                                                            -                           
    SP2:                                                                                            -           -               
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                            -                           


    ECgene alternative splicing isoforms for RHOBTB3

    Expression
    for RHOBTB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOBTB3 expression in normal human tissues (normalized intensities)      RHOBTB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCTTCAT
    RHOBTB3 Expression
    About this image


    RHOBTB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             Cardiac Myocytes   
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Mesoderm (Gastrulation Derivatives)
             Mesoderm-like cells ( Derivation of cardiomyocytes from pluripotent stem cells and...

    See RHOBTB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOBTB3

    SOURCE GeneReport for Unigene cluster: Hs.445030

    UniProtKB/Swiss-Prot: RHBT3_HUMAN, O94955
    Tissue specificity: Ubiquitous. Highly expressed in neural and cardiac tissues, pancreas, placenta and testis

        SABiosciences Expression via Pathway-Focused PCR Array including RHOBTB3: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Orthologs
    for RHOBTB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RHOBTB3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rhobtb31 , 5 Rho-related BTB domain containing 31, 5 89.8(n)1
    95.74(a)1    		   13 (40.95 cM)5
    732961  NM_028493.21  NP_082769.11 
     758695375 
    chicken
    (Gallus gallus)    		 Aves RHOBTB31 Rho-related BTB domain containing 3 72.19(n)
    72.52(a)    		   431569  XM_429123.3  XP_429123.3 
    lizard
    (Anolis carolinensis)    		 Reptilia RHOBTB36
    		 Rho-related BTB domain containing 3
    		 75(a)
    		 1 ↔ 1
    		 2(25968458-26010080)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5628041 rho-related BTB domain-containing protein 3-like 53.76(n)
    48.08(a)    		   562804  XM_686178.5  XP_691270.5 


    ENSEMBL Gene Tree for RHOBTB3 (if available)
    TreeFam Gene Tree for RHOBTB3 (if available)

    Paralogs
    for RHOBTB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOBTB3 gene
    1 SIMAP similar gene for RHOBTB3 using alignment to 10 protein entries:     RHBT3_HUMAN (see all proteins):
    BTBD9

    RHOBTB3 for paralogs           About GeneDecksing



    Genomic Variants
    for RHOBTB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1272 SNPs in RHOBTB3 are shown (see all 1272)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1410519421,2
    		Cuntested195091233(+) AAGATC/TGTTCT 2 I syn10--------
    rs1895994881,2
    		--95064851(+) TGCCTA/GTGGAG 1 -- us2k10--------
    rs1426392861,2
    		C--95064854(+) CTATGA/GAGTAG 1 -- us2k10--------
    rs1808560241,2
    		--95065235(+) GTACAC/TGCTCT 1 -- us2k10--------
    rs1853101651,2
    		C--95065293(+) AGTACA/GAACTA 1 -- us2k10--------
    rs1509869231,2
    		--95065321(+) ACAGAC/TCTCTG 1 -- us2k10--------
    rs1412723591,2
    		C--95065374(+) ACAACA/GCCCCC 1 -- us2k10--------
    rs1900710991,2
    		--95065379(+) GCCCCC/GTTTTC 1 -- us2k10--------
    rs1834509371,2
    		--95065653(+) TTTCCA/GGAAAA 1 -- us2k10--------
    rs1450661431,2
    		C--95065744(+) TTCTAC/GAGACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHOBTB3 (95049226 - 95160087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RHOBTB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830409CNV Gain17160897

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    Disorders / Diseases
    for RHOBTB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RHOBTB3 for disorders           About MalaCards
    OMIM gene information: 607353    OMIM disorders: --


    RHOBTB3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RHOBTB3
    Human Genome Epidemiology (HuGE) Navigator: RHOBTB3 (1 document)

    Export disorders for RHOBTB3 gene to outside databases

    Publications
    for RHOBTB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOBTB3 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with RHOBTB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    2. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. (PubMed id 19490898)1, 2 Espinosa E.J.... Pfeffer S.R. (2009)
    3. Evolution of the Rho family of ras-like GTPases in eukaryotes. (PubMed id 17035353)1, 3 Boureux A....Fort P. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. (PubMed id 12426103)1, 2 Ramos S.... Rivero F. (2002)
    7. The Dictyostelium discoideum family of Rho-related proteins. (PubMed id 11222756)1, 3 Rivero F....Noegel A.A. (2001)
    8. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. RhoBTB3 interacts with the 5-HT7a receptor and inhibit s its proteasomal degradation. (PubMed id 22245496)1 Matthys A....Vanhoenacker P. (2012)

    External Searches for RHOBTB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing RHOBTB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22836 HGNC: 18757 AceView: RHOBTB3 Ensembl:ENSG00000164292 euGenes: HUgn22836
    ECgene: RHOBTB3 H-InvDB: RHOBTB3

    Other Databases showing RHOBTB3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0878

    Specialized Databases showing RHOBTB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOBTB3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RHOBTB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RHOBTB3 gene:
    Search GeneIP for patents involving RHOBTB3

    GeneCards and IP:
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