RHOBTB3 Gene

Aliases
for RHOBTB3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC05P094324 GC05P095531 GC05P095082 GC05P095141 GC05P090257

Summaries
for RHOBTB3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for RHOBTB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000005.9  NC_018916.2  NT_034772.7  

SwitchGear Promoter luciferase reporter plasmid: RHOBTB3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOBTB3

RHOBTB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P095092:  view genomic region     (about GC identifiers)

Proteins
for RHOBTB3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for RHOBTB3: NX_O94955

Explore proteomics data for RHOBTB3 at MOPED

Post-translational modifications: 

RHOBTB3 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for RHOBTB3 OriGene Custom MassSpec OriGene Custom Protein Services for RHOBTB3
	GenScript Custom Purified and Recombinant Proteins Services for RHOBTB3
	Novus Biologicals RHOBTB3 Proteins Novus Biologicals RHOBTB3 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RHOBTB3
	Search eBioscience for Proteins for RHOBTB3
	Search GeneTex for Proteins for RHOBTB3
	antibodies-online proteins for RHOBTB3 (6 products)
	Search antibodies-online for peptides for RHOBTB3

RHOBTB3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for RHOBTB3 OriGene Custom Antibody Services for RHOBTB3
	Novus Biologicals RHOBTB3 Antibodies
	Abcam antibodies for RHOBTB3
	Cloud-Clone Corp. Antibodies for RHOBTB3
	Search ThermoFisher Antibodies for RHOBTB3
	antibodies-online antibodies for RHOBTB3 (12 products)

RHOBTB3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RHOBTB3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RHOBTB3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RHOBTB3 Cloud-Clone Corp. CLIAs for RHOBTB3
	Search eBioscience for ELISAs for RHOBTB3
	antibodies-online kits for RHOBTB3 (4 products)

Domains /
Families
for RHOBTB3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: O94955

Find genes that share domains with RHOBTB3           About GenesLikeMe

Function
for RHOBTB3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Enzyme Number (IUBMB): EC 3.6.1.-¹

     Gene Ontology (GO): 5 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Rhobtb3)

genOway: Develop your customized and physiologically relevant rodent model for RHOBTB3

miRNA Products:		miRTarBase miRNAs that target RHOBTB3: hsa-mir-98-5p (MIRT027831), hsa-mir-215-5p (MIRT024323), hsa-mir-192-5p (MIRT026931)
		Block miRNA regulation of human, mouse, rat RHOBTB3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate RHOBTB3 (see all 48):
		hsa-miR-142-5p hsa-miR-548j hsa-miR-548k hsa-miR-578 hsa-miR-548l hsa-miR-183* hsa-miR-208b hsa-miR-208a
		SwitchGear 3'UTR luciferase reporter plasmid: RHOBTB3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RHOBTB3
		Predesigned siRNA for gene silencing in human, mouse, rat RHOBTB3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RHOBTB3

Clone Products:		OriGene clones in human, mouse for RHOBTB3 (see all 6) OriGene ORF clones in mouse, rat for RHOBTB3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RHOBTB3 (NM_014899)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOBTB3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOBTB3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RHOBTB3
		Browse ESI BIO Cell Lines and PureStem Progenitors for RHOBTB3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB3

Localization
for RHOBTB3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
golgi apparatus	5
cytosol	2
endoplasmic reticulum	1
endosome	1
extracellular	1
mitochondrion	1
nucleus	1
peroxisome	1
plasma membrane	1

About this image

Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for RHOBTB3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for RHOBTB3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for RHOBTB3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for RHOBTB3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHOBTB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGCTTCAT

About this image

NULL (Uncategorized)    fully expand to see all 4 entries
Definitive endoderm-like cells
Ovary (Reproductive System)
Cumulus Cells Antral Follicle
Adipose (Muscoskeletal System)
White adipocyte-like cells
Primitive Streak (Early Embryonic Tissues)
Primitive streak-like cells
Neural Tube (Nervous System)
Telencephalon

Primer Products:		OriGene qPCR primer pairs and template standards for RHOBTB3 OriGene qSTAR qPCR primer pairs in human, mouse for RHOBTB3
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOBTB3
		QuantiTect SYBR Green Assays in human, mouse, rat RHOBTB3
		QuantiFast Probe-based Assays in human, mouse, rat RHOBTB3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB3

Orthologs
for RHOBTB3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for RHOBTB3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for RHOBTB3 gene

1 SIMAP similar gene for RHOBTB3 using alignment to 10 protein entries:     RHBT3_HUMAN (see all proteins):

BTBD9

Find genes that share paralogs with RHOBTB3           About GenesLikeMe

Genomic Variants
for RHOBTB3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for RHOBTB3 (see all 1272)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1410519421,2	C	untested1	95091233(+)	AAGATC/TGTTCT	2	I	syn1		0	--	--	--	--
rs1895994881,2		--	95064851(+)	TGCCTA/GTGGAG	1	--	us2k1		0	--	--	--	--
rs1426392861,2	C	--	95064854(+)	CTATGA/GAGTAG	1	--	us2k1		0	--	--	--	--
rs1808560241,2		--	95065235(+)	GTACAC/TGCTCT	1	--	us2k1		0	--	--	--	--
rs1853101651,2	C	--	95065293(+)	AGTACA/GAACTA	1	--	us2k1		0	--	--	--	--
rs1509869231,2		--	95065321(+)	ACAGAC/TCTCTG	1	--	us2k1		0	--	--	--	--
rs1412723591,2	C	--	95065374(+)	ACAACA/GCCCCC	1	--	us2k1		0	--	--	--	--
rs1900710991,2		--	95065379(+)	GCCCCC/GTTTTC	1	--	us2k1		0	--	--	--	--
rs1834509371,2		--	95065653(+)	TTTCCA/GGAAAA	1	--	us2k1		0	--	--	--	--
rs1450661431,2	C	--	95065744(+)	TTCTAC/GAGACT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for RHOBTB3 (95049226 - 95160087 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for RHOBTB3:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv830409	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RHOBTB3

DNA2.0 Custom Variant and Variant Library Synthesis for RHOBTB3

Disorders / Diseases
for RHOBTB3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for RHOBTB3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)^{1, 4} Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
2. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. (PubMed id 19490898)^{1, 2} Espinosa E.J.... Pfeffer S.R. (Cell 2009)
3. Evolution of the Rho family of ras-like GTPases in eukaryotes. (PubMed id 17035353)^{1, 3} Boureux A....Fort P. (Mol. Biol. Evol. 2007)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
6. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. (PubMed id 12426103)^{1, 2} Ramos S.... Rivero F. (Gene 2002)
7. The Dictyostelium discoideum family of Rho-related proteins. (PubMed id 11222756)^{1, 3} Rivero F....Noegel A.A. (Nucleic Acids Res. 2001)
8. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2} Nagase T.... Ohara O. (DNA Res. 1998)
9. Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. (PubMed id 24145166)¹ Lu A. and Pfeffer S.R. (J. Cell Biol. 2013)
10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

External Searches for RHOBTB3 gene

Genome Databases showing RHOBTB3 gene

Other Databases showing RHOBTB3 gene

Specialized Databases showing RHOBTB3 gene

Products
for RHOBTB3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section