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RHOBTB2 Gene

protein-coding   GIFtS: 59
GCID: GC08P022844

Rho-Related BTB Domain Containing 2

  See RHOBTB2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho-Related BTB Domain Containing 21 2
DBC22 3 5
Deleted In Breast Cancer 2 Gene Protein2 3
p832 3
KIAA07173 5
Rho-Related BTB Domain-Containing Protein 22

External Ids:    HGNC: 187561   Entrez Gene: 232212   Ensembl: ENSG000000088537   OMIM: 6073525   UniProtKB: Q9BYZ63   

Export aliases for RHOBTB2 gene to outside databases

Previous GC identifers: GC08P022626 GC08P023198 GC08P022866 GC08P022880 GC08P022900 GC08P021389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHOBTB2 Gene:
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein
interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein
inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for RHOBTB2 Gene:
RHOBTB2 (Rho-related BTB domain containing 2) is a protein-coding gene. Diseases associated with RHOBTB2 include breast cancer. GO annotations related to this gene include GTP binding. An important paralog of this gene is RHOH.

Gene Wiki entry for RHOBTB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOBTB2 gene promoter:
         Egr-3   NF-1/L   NF-1   CUTL1   YY1   RORalpha2   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOBTB2 promoter sequence
   Search Chromatin IP Primers for RHOBTB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOBTB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.2

RHOBTB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOBTB2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P022844:  view genomic region     (about GC identifiers)

Start:
22,844,930 bp from pter      End:
22,877,712 bp from pter
Size:
32,783 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHBT2_HUMAN, Q9BYZ6 (See protein sequence)
Recommended Name: Rho-related BTB domain-containing protein 2  
Size: 727 amino acids; 82626 Da
Sequence caution: Sequence=BAA34437.2; Type=Erroneous initiation;
Secondary accessions: D3DSR8 O94825 Q8N4A8 Q9BZK6

Explore the universe of human proteins at neXtProt for RHOBTB2: NX_Q9BYZ6

Explore proteomics data for RHOBTB2 at MOPED


See RHOBTB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001153508.1  NP_001153509.1  NP_055993.2  

ENSEMBL proteins: 
 ENSP00000427926   ENSP00000430785   ENSP00000429141   ENSP00000251822  
Reactome Protein details: Q9BYZ6

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antibodies-online proteins for RHOBTB2 (6 products) 

 
antibodies-online peptides for RHOBTB2

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
BTBD: BTB/POZ domain containing

Selected InterPro protein domains (see all 6):
 IPR003578 Small_GTPase_Rho
 IPR001806 Small_GTPase
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR027417 P-loop_NTPase

Graphical View of Domain Structure for InterPro Entry Q9BYZ6

ProtoNet protein and cluster: Q9BYZ6

4 Blocks protein domains:
IPB000210 BTB/POZ domain
IPB001806 Transforming protein P21 RAS signature
IPB003577 Ras small GTPase
IPB003578 Ras small GTPase


UniProtKB/Swiss-Prot: RHBT2_HUMAN, Q9BYZ6
Similarity: Belongs to the small GTPase superfamily. Rho family
Similarity: Contains 2 BTB (POZ) domains


Find genes that share domains with RHOBTB2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0005525GTP binding IEA--
     
Find genes that share ontologies with RHOBTB2           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for RHOBTB2

miRNA
Products:
    
miRTarBase miRNAs that target RHOBTB2:
hsa-mir-421 (MIRT039445), hsa-mir-106b-5p (MIRT044286)

Block miRNA regulation of human, mouse, rat RHOBTB2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RHOBTB2 (see all 29):
hsa-miR-125a-5p hsa-miR-330-5p hsa-miR-10b hsa-miR-15a hsa-miR-410 hsa-miR-583 hsa-miR-103a hsa-miR-424
SwitchGear 3'UTR luciferase reporter plasmidRHOBTB2 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for RHOBTB2
Predesigned siRNA for gene silencing in human, mouse, rat RHOBTB2

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOBTB2

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
plasma membrane4
nucleus2
cytoskeleton1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005829cytosol TAS--
GO:0005886plasma membrane TAS--
GO:0016020membrane ----

Find genes that share ontologies with RHOBTB2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RHOBTB2 About    
See pathways by source

SuperPathContained pathways About
1Rho GTPase cycle
Rho GTPase cycle1.00
Signaling by Rho GTPases1.00
2Signaling by GPCR
Signal Transduction0.58
3Class I MHC mediated antigen processing and presentation
Ubiquitin mediated proteolysis0.35


Find genes that share SuperPaths with RHOBTB2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for RHOBTB2
    Rho GTPase cycle


1 Kegg Pathway  (Kegg details for RHOBTB2):
    Ubiquitin mediated proteolysis

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHOBTB2
Interactions:

    GeneGlobe Interaction Network for RHOBTB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RHOBTB2 (Q9BYZ63 ENSP000002518224) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
InteractantInteraction Details
GeneCardExternal ID(s)
KDM5BQ9UGL13, ENSP000003562344I2D: score=1 STRING: ENSP00000356234
ARHGAP35ENSP000003857204STRING: ENSP00000385720
ARHGAP39ENSP000003665224STRING: ENSP00000366522
ARHGAP40ENSP000003624424STRING: ENSP00000362442
ARHGAP5ENSP000003718974STRING: ENSP00000371897
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process ----
GO:0007165signal transduction ----
GO:0007264small GTPase mediated signal transduction TAS--
GO:0015031protein transport ----
GO:0051056regulation of small GTPase mediated signal transduction TAS--

Find genes that share ontologies with RHOBTB2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RHOBTB2 (RHBT2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RHOBTB2 gene (3 alternative transcripts): 
NM_001160036.1  NM_001160037.1  NM_015178.2  

Unigene Cluster for RHOBTB2:

Rho-related BTB domain containing 2
Hs.372688  [show with all ESTs]
Unigene Representative Sequence: AB018260
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000519685 ENST00000524077 ENST00000518534 ENST00000522948(uc011kzp.1)
ENST00000251822(uc003xcp.2 uc003xcq.2) ENST00000517528 ENST00000523918
ENST00000519210
miRNA
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Block miRNA regulation of human, mouse, rat RHOBTB2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RHOBTB2 (see all 29):
hsa-miR-125a-5p hsa-miR-330-5p hsa-miR-10b hsa-miR-15a hsa-miR-410 hsa-miR-583 hsa-miR-103a hsa-miR-424
SwitchGear 3'UTR luciferase reporter plasmidRHOBTB2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RHOBTB2
Predesigned siRNA for gene silencing in human, mouse, rat RHOBTB2
Clone
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OriGene clones in human, mouse for RHOBTB2 (see all 18)
OriGene ORF clones in mouse, rat for RHOBTB2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): RHOBTB2 (NM_015178)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOBTB2
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for RHOBTB2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOBTB2
  QuantiTect SYBR Green Assays in human, mouse, rat RHOBTB2
  QuantiFast Probe-based Assays in human, mouse, rat RHOBTB2

Additional mRNA sequence: 

AB018260.2 AK092617.1 AK098744.1 AK292863.1 AK314366.1 AY009093.1 BC034917.1 

15 DOTS entries:

DT.97846572  DT.100797527  DT.312740  DT.101985073  DT.100797525  DT.100751809  DT.92420051  DT.75156341 
DT.101968255  DT.100649285  DT.95135257  DT.95308039  DT.97846569  DT.102842569  DT.121466104 

Selected AceView cDNA sequences (see all 163):

AA968920 BF434521 BQ962438 AI244907 AA281160 AI810660 AA847244 CA393521 
BQ059322 BM826032 BC034917 BQ059158 BQ056640 BU527252 F10718 D31009 
BM710496 CD626832 BF476551 AA877174 BQ066763 AB018260 BQ064841 AA843115 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB2 (see all 9)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1:              -                 -     -     -     -           -                                                                                             
SP2:                                      -     -     -           -                                                                                             
SP3:                                                  -           -                                                                                             
SP4:                                                                                                                                                            
SP5:                                                                                                                                                            


ECgene alternative splicing isoforms for RHOBTB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RHOBTB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GATTCATAAA
RHOBTB2 Expression
About this image


RHOBTB2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Lung (Respiratory System)
         Alveolar type II cells
RHOBTB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RHOBTB2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.372688

UniProtKB/Swiss-Prot: RHBT2_HUMAN, Q9BYZ6
Tissue specificity: Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung,
heart, and brain

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RHOBTB2 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rhobtb21 , 5 Rho-related BTB domain containing 21, 5 90.59(n)1
98.16(a)1
  14 (36.10 cM)5
2467101  NM_153514.51  NP_705734.41 
 697849905 
chicken
(Gallus gallus)
Aves RHOBTB21 Rho-related BTB domain containing 2 81.89(n)
90.25(a)
  419536  XM_001232709.3  XP_001232710.3 
lizard
(Anolis carolinensis)
Reptilia RHOBTB26
Rho-related BTB domain containing 2
80(a)
1 ↔ 1
GL343679.1(119574-156399)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rhobtb21 Rho-related BTB domain containing 2 71.91(n)
80.69(a)
  100144291  XM_002932706.2  XP_002932752.2 
zebrafish
(Danio rerio)
Actinopterygii Dr.164082 Transcribed sequence with strong similarity to protein more 80.07(n)    BI476282.1 
fruit fly
(Drosophila melanogaster)
Insecta RhoBTB1 RhoBTB 55.03(n)
45.49(a)
  40249  NM_001275179.1  NP_001262108.1 


ENSEMBL Gene Tree for RHOBTB2 (if available)
TreeFam Gene Tree for RHOBTB2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RHOBTB2 gene
RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RAC12  RAC22  
CDC422  RHOJ2  RAC32  
18 SIMAP similar genes for RHOBTB2 using alignment to 4 protein entries:     RHBT2_HUMAN (see all proteins):
RHOBTB1    ARHA    RAC3    RAC2    RAC1    ARHG
RHOG    CDC42    RHOA    RHOC    RHOB    RHOD
RHOQ    RHOV    RHOU    RHOJ    RHOH    RND2

Find genes that share paralogs with RHOBTB2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RHOBTB2 (see all 788)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1172955801,2
C,F--22842940(+) TAGGAG/AGCTGC 1 -- us2k11Minor allele frequency- A:0.05EA 120
rs1409916131,2
C--22843082(+) CTCTTA/GTGGCT 1 -- us2k10--------
rs568969821,2
C,F--22843119(+) TATGGC/TCAGTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs609887361,2
C--22843197(+) TTTTCC/TGGCAT 1 -- us2k12Minor allele frequency- T:0.09WA 120
rs1855256981,2
--22843357(+) TAAGGA/GCATTG 1 -- us2k10--------
rs732188001,2
--22843426(+) AGCCCA/TGCAGG 1 -- us2k10--------
rs1884776831,2
--22843448(+) CCTTCC/TCAACA 1 -- us2k10--------
rs1388605861,2
--22843525(+) AGGTCA/CAGGAC 1 -- us2k10--------
rs126766381,2
C,F,H--22843545(+) AGAGAT/AGGGAA 1 -- us2k17Minor allele frequency- A:0.10NS EA NA 634
rs1440059881,2
C--22843653(+) GGACT-/TCTTCTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RHOBTB2 (22844930 - 22877712 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for RHOBTB2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2663907CNV Deletion23128226
nsv522436CNV Loss19592680
nsv526377CNV Loss19592680
nsv524231CNV Loss19592680
nsv890679CNV Gain21882294
nsv8323CNV Gain18304495
essv19243CNV CNV17122850

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607352    OMIM disorders: --

1 disease for RHOBTB2:    
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breast cancer

1 disease from the University of Copenhagen DISEASES database for RHOBTB2:
Lyme disease

Find genes that share disorders with RHOBTB2           About GenesLikeMe

3 Novoseek inferred disease relationships for RHOBTB2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer 41.5 26 19937980 (6), 12370419 (4), 18374159 (1), 17906984 (1) (see all 5)
tumors 22.3 14 12370419 (3), 19937980 (3), 18640857 (2), 18374159 (1) (see all 7)
cancer 10.6 3 15922864 (1), 17906984 (1)

Genetic Association Database (GAD): RHOBTB2
Human Genome Epidemiology (HuGE) Navigator: RHOBTB2 (3 documents)

Export disorders for RHOBTB2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RHOBTB2 gene, integrated from 10 sources (see all 35):
(articles sorted by number of sources associating them with RHOBTB2)
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  1. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PubMed id 19714462)1, 4 Loizidou M.A....Kyriacou K. (Breast Cancer Res. Treat. 2010)
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. (PubMed id 12426103)1, 2 Ramos S.... Rivero F. (Gene 2002)
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
  6. The Dictyostelium discoideum family of Rho-related proteins. (PubMed id 11222756)1, 3 Rivero F....Noegel A.A. (Nucleic Acids Res. 2001)
  7. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
  8. RhoBTB2 (DBC2) is a mitotic E2F1 target gene with a novel role in apoptosis. (PubMed id 18039672)1, 9 Freeman S.N....Cress W.D. (J. Biol. Chem. 2008)
  9. A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. (PubMed id 19937980)1, 9 Mao H....Zhang L. (Mol. Carcinog. 2010)
  10. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. (PubMed id 12370419)1, 9 Hamaguchi M.... Wigler M.H. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23221 HGNC: 18756 AceView: RHOBTB2 Ensembl:ENSG00000008853 euGenes: HUgn23221
ECgene: RHOBTB2 Kegg: 23221 H-InvDB: RHOBTB2

(According to HUGE)
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HUGE: KIAA0717

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RHOBTB2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RHOBTB2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RHOBTB2 gene:
Search GeneIP for patents involving RHOBTB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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