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Aliases for RHOBTB2 Gene

Aliases for RHOBTB2 Gene

  • Rho Related BTB Domain Containing 2 2 3
  • Rho-Related BTB Domain Containing 2 2 3 5
  • Deleted In Breast Cancer 2 Gene Protein 3 4
  • DBC2 3 4
  • P83 3 4
  • KIAA0717 4

External Ids for RHOBTB2 Gene

Previous GeneCards Identifiers for RHOBTB2 Gene

  • GC08P022626
  • GC08P023198
  • GC08P022866
  • GC08P022880
  • GC08P022900
  • GC08P021389
  • GC08P022844

Summaries for RHOBTB2 Gene

Entrez Gene Summary for RHOBTB2 Gene

  • The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for RHOBTB2 Gene

RHOBTB2 (Rho Related BTB Domain Containing 2) is a Protein Coding gene. Diseases associated with RHOBTB2 include Breast Cancer. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Signaling by Rho GTPases. GO annotations related to this gene include GTP binding. An important paralog of this gene is RHOA.

Gene Wiki entry for RHOBTB2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOBTB2 Gene

Genomics for RHOBTB2 Gene

Regulatory Elements for RHOBTB2 Gene

Enhancers for RHOBTB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RHOBTB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOBTB2 Gene

22,987,258 bp from pter
23,020,199 bp from pter
32,942 bases
Plus strand

Genomic View for RHOBTB2 Gene

Genes around RHOBTB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOBTB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOBTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOBTB2 Gene

Proteins for RHOBTB2 Gene

  • Protein details for RHOBTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related BTB domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K9Z8
    • D3DSR8
    • E9PBU2
    • E9PEI7
    • O94825
    • Q8N4A8
    • Q9BZK6

    Protein attributes for RHOBTB2 Gene

    727 amino acids
    Molecular mass:
    82626 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA34437.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOBTB2 Gene


neXtProt entry for RHOBTB2 Gene

Proteomics data for RHOBTB2 Gene at MOPED

Post-translational modifications for RHOBTB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOBTB2 Gene

No data available for DME Specific Peptides for RHOBTB2 Gene

Domains & Families for RHOBTB2 Gene

Gene Families for RHOBTB2 Gene

Suggested Antigen Peptide Sequences for RHOBTB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 BTB (POZ) domains.
  • Belongs to the small GTPase superfamily. Rho family.
  • Contains 2 BTB (POZ) domains.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOBTB2: view

Function for RHOBTB2 Gene

Phenotypes for RHOBTB2 Gene

genes like me logo Genes that share phenotypes with RHOBTB2: view

Animal Model Products

CRISPR Products

miRNA for RHOBTB2 Gene

miRTarBase miRNAs that target RHOBTB2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOBTB2 Gene

Localization for RHOBTB2 Gene

Subcellular locations from

Jensen Localization Image for RHOBTB2 Gene COMPARTMENTS Subcellular localization image for RHOBTB2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOBTB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RHOBTB2 Gene

Pathways & Interactions for RHOBTB2 Gene

genes like me logo Genes that share pathways with RHOBTB2: view

Pathways by source for RHOBTB2 Gene

3 Reactome pathways for RHOBTB2 Gene
1 KEGG pathway for RHOBTB2 Gene

Gene Ontology (GO) - Biological Process for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOBTB2: view

No data available for SIGNOR curated interactions for RHOBTB2 Gene

Drugs & Compounds for RHOBTB2 Gene

No Compound Related Data Available

Transcripts for RHOBTB2 Gene

Unigene Clusters for RHOBTB2 Gene

Rho-related BTB domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP6: - - - - -
SP7: -
SP8: -

Relevant External Links for RHOBTB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOBTB2 Gene

mRNA expression in normal human tissues for RHOBTB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RHOBTB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RHOBTB2 Gene

SOURCE GeneReport for Unigene cluster for RHOBTB2 Gene Hs.372688

mRNA Expression by UniProt/SwissProt for RHOBTB2 Gene

Tissue specificity: Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.
genes like me logo Genes that share expression patterns with RHOBTB2: view

Protein tissue co-expression partners for RHOBTB2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for RHOBTB2 Gene

Orthologs for RHOBTB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOBTB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RHOBTB2 35
  • 92.1 (n)
  • 97.87 (a)
-- 36
  • 97 (a)
  • 94 (a)
(Canis familiaris)
Mammalia RHOBTB2 35
  • 92.02 (n)
  • 97.25 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rhobtb2 35
  • 90.59 (n)
  • 98.16 (a)
Rhobtb2 16
Rhobtb2 36
  • 98 (a)
(Pan troglodytes)
Mammalia RHOBTB2 35
  • 99.64 (n)
  • 99.73 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rhobtb2 35
  • 90.64 (n)
  • 98.01 (a)
(Monodelphis domestica)
Mammalia RHOBTB2 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia RHOBTB2 36
  • 79 (a)
(Gallus gallus)
Aves RHOBTB2 35
  • 81.89 (n)
  • 90.25 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia RHOBTB2 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhobtb2 35
  • 71.91 (n)
  • 80.69 (a)
(Danio rerio)
Actinopterygii Dr.16408 35
rhobtb2b 35
  • 72.31 (n)
  • 78.65 (a)
rhobtb2b 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3851 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006474 35
  • 53.03 (n)
  • 43.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoBTB 35
  • 55.03 (n)
  • 45.49 (a)
RhoBTB 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
CSA.4181 36
  • 38 (a)
Species with no ortholog for RHOBTB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOBTB2 Gene

Gene Tree for RHOBTB2 (if available)
Gene Tree for RHOBTB2 (if available)

Paralogs for RHOBTB2 Gene

Paralogs for RHOBTB2 Gene

(18) SIMAP similar genes for RHOBTB2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RHOBTB2: view

Variants for RHOBTB2 Gene

Sequence variations from dbSNP and Humsavar for RHOBTB2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2270408 -- 23,005,135(+) TCCAC(C/G)TGCTT intron-variant
rs2430807 -- 23,001,794(+) AGGGT(A/G)AGATG intron-variant
rs2430808 -- 23,002,285(+) TCCTG(A/G)CGCCA intron-variant, upstream-variant-2KB
rs2430809 -- 23,003,729(+) ACCCC(A/G)AATAG intron-variant, upstream-variant-2KB
rs2430810 -- 23,003,731(+) CCCGA(A/G)TAGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RHOBTB2 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
nsv890679 CNV Gain 21882294
nsv8323 CNV Gain 18304495
nsv526377 CNV Loss 19592680
nsv522436 CNV Loss 19592680
nsv524231 CNV Loss 19592680
esv2663907 CNV Deletion 23128226

Variation tolerance for RHOBTB2 Gene

Residual Variation Intolerance Score: 9.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RHOBTB2 Gene

Disorders for RHOBTB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RHOBTB2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RHOBTB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RHOBTB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOBTB2 Gene

Publications for RHOBTB2 Gene

  1. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PMID: 19714462) Loizidou M.A. … Kyriacou K. (Breast Cancer Res. Treat. 2010) 3 48 67
  2. A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. (PMID: 19937980) Mao H. … Zhang L. (Mol. Carcinog. 2010) 3 23
  3. Genetic analysis of the DBC2 gene in gastric cancer. (PMID: 17906984) Cho Y.G. … Park W.S. (Acta Oncol 2008) 3 23
  4. RhoBTB2 (DBC2) is a mitotic E2F1 target gene with a novel role in apoptosis. (PMID: 18039672) Freeman S.N. … Cress W.D. (J. Biol. Chem. 2008) 3 23
  5. DBC2 gene is silenced by promoter methylation in bladder cancer. (PMID: 18640857) Shi Y. … Xiao C.G. (Urol. Oncol. 2008) 3 23

Products for RHOBTB2 Gene

Sources for RHOBTB2 Gene