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Aliases for RHOBTB2 Gene

Aliases for RHOBTB2 Gene

  • Rho-Related BTB Domain Containing 2 2 3
  • DBC2 3 4 6
  • Deleted In Breast Cancer 2 Gene Protein 3 4
  • KIAA0717 4 6
  • P83 3 4
  • Rho-Related BTB Domain-Containing Protein 2 3

External Ids for RHOBTB2 Gene

Summaries for RHOBTB2 Gene

Entrez Gene Summary for RHOBTB2 Gene

  • The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for RHOBTB2 Gene

RHOBTB2 (Rho-Related BTB Domain Containing 2) is a Protein Coding gene. Diseases associated with RHOBTB2 include breast cancer. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAC2.

Gene Wiki entry for RHOBTB2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOBTB2 Gene

Genomics for RHOBTB2 Gene

Genomic Location for RHOBTB2 Gene

22,987,411 bp from pter
23,020,199 bp from pter
32,789 bases
Plus strand

Genomic View for RHOBTB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOBTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOBTB2 Gene

Regulatory Elements for RHOBTB2 Gene

Proteins for RHOBTB2 Gene

  • Protein details for RHOBTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related BTB domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K9Z8
    • D3DSR8
    • E9PBU2
    • E9PEI7
    • O94825
    • Q8N4A8
    • Q9BZK6

    Protein attributes for RHOBTB2 Gene

    727 amino acids
    Molecular mass:
    82626 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA34437.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOBTB2 Gene


neXtProt entry for RHOBTB2 Gene

Proteomics data for RHOBTB2 Gene at MOPED

Post-translational modifications for RHOBTB2 Gene

No Post-translational modifications

Other Protein References for RHOBTB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOBTB2 Gene

Domains for RHOBTB2 Gene

Gene Families for RHOBTB2 Gene

  • BTBD :BTB/POZ domain containing


  • Contains 2 BTB (POZ) domains.:
    • Q9BYZ6
  • Belongs to the small GTPase superfamily. Rho family.:
    • Q9BYZ6
genes like me logo Genes that share domains with RHOBTB2: view

Function for RHOBTB2 Gene

Gene Ontology (GO) - Molecular Function for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOBTB2: view

miRNA for RHOBTB2 Gene

miRTarBase miRNAs that target RHOBTB2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RHOBTB2 Gene

Localization for RHOBTB2 Gene

Subcellular locations from

Jensen Localization Image for RHOBTB2 Gene COMPARTMENTS Subcellular localization image for RHOBTB2 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RHOBTB2: view

Pathways for RHOBTB2 Gene

genes like me logo Genes that share pathways with RHOBTB2: view

Pathways by source for RHOBTB2 Gene

3 Reactome pathways for RHOBTB2 Gene
1 KEGG pathway for RHOBTB2 Gene

Gene Ontology (GO) - Biological Process for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0015031 protein transport --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOBTB2: view

Transcripts for RHOBTB2 Gene

Unigene Clusters for RHOBTB2 Gene

Rho-related BTB domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP6: - - - - -
SP7: -
SP8: -

Relevant External Links for RHOBTB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOBTB2 Gene

mRNA expression in normal human tissues for RHOBTB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RHOBTB2 Gene

SOURCE GeneReport for Unigene cluster for RHOBTB2 Gene Hs.372688

mRNA Expression by UniProt/SwissProt for RHOBTB2 Gene

Tissue specificity: Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.
genes like me logo Genes that share expressions with RHOBTB2: view

Orthologs for RHOBTB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOBTB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOBTB2 36
  • 99.64 (n)
  • 99.73 (a)
  • 100 (a)
(Bos Taurus)
Mammalia -- 37
  • 97 (a)
  • 92.1 (n)
  • 97.87 (a)
  • 94 (a)
(Canis familiaris)
Mammalia RHOBTB2 36
  • 92.02 (n)
  • 97.25 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rhobtb2 36
  • 90.59 (n)
  • 98.16 (a)
Rhobtb2 16
Rhobtb2 37
  • 98 (a)
(Monodelphis domestica)
Mammalia RHOBTB2 37
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia RHOBTB2 37
  • 79 (a)
(Rattus norvegicus)
Mammalia Rhobtb2 36
  • 90.64 (n)
  • 98.01 (a)
(Gallus gallus)
Aves RHOBTB2 36
  • 81.89 (n)
  • 90.25 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia RHOBTB2 37
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhobtb2 36
  • 71.91 (n)
  • 80.69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3851 36
(Danio rerio)
Actinopterygii Dr.16408 36
rhobtb2b 36
  • 72.31 (n)
  • 78.65 (a)
rhobtb2b 37
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006474 36
  • 53.03 (n)
  • 43.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoBTB 36
  • 55.03 (n)
  • 45.49 (a)
RhoBTB 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
CSA.4181 37
  • 38 (a)
Species with no ortholog for RHOBTB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOBTB2 Gene

Gene Tree for RHOBTB2 (if available)
Gene Tree for RHOBTB2 (if available)

Paralogs for RHOBTB2 Gene

Paralogs for RHOBTB2 Gene

Selected SIMAP similar genes for RHOBTB2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RHOBTB2: view

Variants for RHOBTB2 Gene

Sequence variations from dbSNP and Humsavar for RHOBTB2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2889 -- 23,018,396(-) GTGTT(C/T)GTTGA utr-variant-3-prime
rs741461 -- 22,993,159(+) ttttc(C/T)ttctt intron-variant
rs741462 -- 22,993,160(+) tttct(G/T)tcttt intron-variant
rs759652 -- 23,017,379(+) CCCAA(A/G)CGGCG reference, synonymous-codon
rs765660 -- 22,988,554(-) ATCCT(A/G)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOBTB2 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
nsv890679 CNV Gain 21882294
nsv8323 CNV Gain 18304495
nsv526377 CNV Loss 19592680
nsv522436 CNV Loss 19592680
nsv524231 CNV Loss 19592680
esv2663907 CNV Deletion 23128226

Relevant External Links for RHOBTB2 Gene

HapMap Linkage Disequilibrium report

Disorders for RHOBTB2 Gene

(1) MalaCards Diseases for RHOBTB2 Gene

Search for RHOBTB2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RHOBTB2 Gene

(3) Novoseek inferred disease relationships for RHOBTB2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 41.5 13
tumors 22.3 12
cancer 10.6 2

Relevant External Links for RHOBTB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RHOBTB2: view

No data available for UniProtKB/Swiss-Prot for RHOBTB2 Gene

Publications for RHOBTB2 Gene

  1. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. (PMID: 12370419) Hamaguchi M. … Wigler M.H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  2. RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex. (PMID: 15107402) Wilkins A. … Carpenter C.L. (Genes Dev. 2004) 3 23
  3. DBC2 gene is silenced by promoter methylation in bladder cancer. (PMID: 18640857) Shi Y. … Xiao C.G. (Urol. Oncol. 2008) 3 23
  4. A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. (PMID: 19937980) Mao H. … Zhang L. (Mol. Carcinog. 2010) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for RHOBTB2 Gene

Sources for RHOBTB2 Gene

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