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Aliases for RHOBTB2 Gene

Aliases for RHOBTB2 Gene

  • Rho Related BTB Domain Containing 2 2 3 5
  • Deleted In Breast Cancer 2 Gene Protein 3 4
  • DBC2 3 4
  • P83 3 4
  • Rho-Related BTB Domain-Containing Protein 2 3
  • Rho-Related BTB Domain Containing 2 2
  • KIAA0717 4

External Ids for RHOBTB2 Gene

Previous GeneCards Identifiers for RHOBTB2 Gene

  • GC08P022626
  • GC08P023198
  • GC08P022866
  • GC08P022880
  • GC08P022900
  • GC08P021389
  • GC08P022844

Summaries for RHOBTB2 Gene

Entrez Gene Summary for RHOBTB2 Gene

  • The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for RHOBTB2 Gene

RHOBTB2 (Rho Related BTB Domain Containing 2) is a Protein Coding gene. Diseases associated with RHOBTB2 include Acrodermatitis Chronica Atrophicans and Sporadic Breast Cancer. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. GO annotations related to this gene include GTP binding. An important paralog of this gene is RHOBTB1.

Gene Wiki entry for RHOBTB2 Gene

Additional gene information for RHOBTB2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOBTB2 Gene

Genomics for RHOBTB2 Gene

Regulatory Elements for RHOBTB2 Gene

Enhancers for RHOBTB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H022915 1.5 Ensembl ENCODE dbSUPER 11.3 -70.2 -70192 4.1 PKNOX1 FOXA2 ATF1 ARNT ARID4B SIN3A ZNF2 TCF12 ZNF766 ZNF143 PEBP4 LOC101929237 RHOBTB2 BIN3 CHMP7 ENSG00000253142 GC08P022948
GH08H022998 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9 +14.4 14406 5.9 HDGF ATF1 ARID4B SIN3A YY1 GLIS2 ZNF143 RUNX3 SP3 YY2 RHOBTB2 EGR3 ENSG00000251034 PIR37908 PEBP4
GH08H023049 1.4 Ensembl ENCODE dbSUPER 11.1 +62.8 62803 2 HDGF PKNOX1 ARNT CHAMP1 TCF12 GATA2 EGR1 ZBTB2 ZBTB11 ZEB2 TNFRSF10B RHOBTB2 LOC286059 PIR57431
GH08H022996 0.8 FANTOM5 dbSUPER 18.7 +9.5 9487 0.3 ZSCAN4 ZNF248 RHOBTB2 EGR3 PEBP4
GH08H023017 1.3 ENCODE dbSUPER 11.5 +33.3 33349 6.8 HDGF PKNOX1 ATF1 ARID4B ZNF2 YY1 ETS1 TCF12 ZNF766 GLIS2 RHOBTB2 LOC101929237 LOC107986927 TNFRSF10B PIR53150
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOBTB2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RHOBTB2 Gene

Genomic Locations for RHOBTB2 Gene
32,942 bases
Plus strand

Genomic View for RHOBTB2 Gene

Genes around RHOBTB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOBTB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOBTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOBTB2 Gene

Proteins for RHOBTB2 Gene

  • Protein details for RHOBTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related BTB domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K9Z8
    • D3DSR8
    • E9PBU2
    • E9PEI7
    • O94825
    • Q8N4A8
    • Q9BZK6

    Protein attributes for RHOBTB2 Gene

    727 amino acids
    Molecular mass:
    82626 Da
    Quaternary structure:
    • Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
    • Sequence=AAH34917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA34437.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOBTB2 Gene


neXtProt entry for RHOBTB2 Gene

Post-translational modifications for RHOBTB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOBTB2 Gene

No data available for DME Specific Peptides for RHOBTB2 Gene

Domains & Families for RHOBTB2 Gene

Gene Families for RHOBTB2 Gene

Suggested Antigen Peptide Sequences for RHOBTB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rho family.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOBTB2: view

Function for RHOBTB2 Gene

Phenotypes From GWAS Catalog for RHOBTB2 Gene

Gene Ontology (GO) - Molecular Function for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 26517842
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOBTB2: view

Phenotypes for RHOBTB2 Gene

genes like me logo Genes that share phenotypes with RHOBTB2: view

Animal Model Products

CRISPR Products

miRNA for RHOBTB2 Gene

miRTarBase miRNAs that target RHOBTB2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOBTB2 Gene

Localization for RHOBTB2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOBTB2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOBTB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RHOBTB2 Gene

Pathways & Interactions for RHOBTB2 Gene

genes like me logo Genes that share pathways with RHOBTB2: view

Pathways by source for RHOBTB2 Gene

3 Reactome pathways for RHOBTB2 Gene
1 KEGG pathway for RHOBTB2 Gene

Gene Ontology (GO) - Biological Process for RHOBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOBTB2: view

No data available for SIGNOR curated interactions for RHOBTB2 Gene

Drugs & Compounds for RHOBTB2 Gene

No Compound Related Data Available

Transcripts for RHOBTB2 Gene

Unigene Clusters for RHOBTB2 Gene

Rho-related BTB domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP6: - - - - -
SP7: -
SP8: -

Relevant External Links for RHOBTB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOBTB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOBTB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RHOBTB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RHOBTB2 Gene

Protein tissue co-expression partners for RHOBTB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOBTB2 Gene:


SOURCE GeneReport for Unigene cluster for RHOBTB2 Gene:


mRNA Expression by UniProt/SwissProt for RHOBTB2 Gene:

Tissue specificity: Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.

Evidence on tissue expression from TISSUES for RHOBTB2 Gene

  • Nervous system(4.8)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with RHOBTB2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOBTB2 Gene

Orthologs for RHOBTB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOBTB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOBTB2 33 34
  • 99.64 (n)
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
RHOBTB2 34 33
  • 92.1 (n)
(Monodelphis domestica)
Mammalia RHOBTB2 34
  • 97 (a)
(Canis familiaris)
Mammalia RHOBTB2 33 34
  • 92.02 (n)
(Rattus norvegicus)
Mammalia Rhobtb2 33
  • 90.64 (n)
(Mus musculus)
Mammalia Rhobtb2 33 16 34
  • 90.59 (n)
(Ornithorhynchus anatinus)
Mammalia RHOBTB2 34
  • 79 (a)
(Gallus gallus)
Aves RHOBTB2 33 34
  • 81.89 (n)
(Anolis carolinensis)
Reptilia RHOBTB2 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhobtb2 33
  • 71.91 (n)
(Danio rerio)
Actinopterygii rhobtb2b 33 34
  • 72.31 (n)
Dr.16408 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3851 33
fruit fly
(Drosophila melanogaster)
Insecta RhoBTB 33 34
  • 55.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006474 33
  • 53.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
CSA.4181 34
  • 38 (a)
Species where no ortholog for RHOBTB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOBTB2 Gene

Gene Tree for RHOBTB2 (if available)
Gene Tree for RHOBTB2 (if available)

Paralogs for RHOBTB2 Gene

Paralogs for RHOBTB2 Gene

(18) SIMAP similar genes for RHOBTB2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RHOBTB2: view

Variants for RHOBTB2 Gene

Sequence variations from dbSNP and Humsavar for RHOBTB2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs193920745 Uncertain significance 23,006,055(+) CTGCC(C/G)CCGAG downstream-variant-500B, reference, missense
rs1000041077 -- 23,015,120(+) CCTAC(-/TCCCTTAA)TCCCA intron-variant
rs1000178284 -- 23,008,996(+) TATAG(A/G)GCCAG intron-variant
rs1000209745 -- 23,009,365(+) CTTAG(C/G)TTTGG intron-variant
rs1000241315 -- 22,987,250(+) CCTGG(C/T)CAAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RHOBTB2 Gene

Variant ID Type Subtype PubMed ID
nsv8323 CNV gain 18304495
nsv526377 CNV loss 19592680
nsv524231 CNV loss 19592680
nsv522436 CNV loss 19592680
nsv1119171 CNV deletion 24896259
nsv1027718 CNV gain 25217958
nsv1025672 CNV gain 25217958
nsv1017570 CNV gain 25217958
esv3616620 CNV loss 21293372
esv2759604 CNV loss 17122850
esv2663907 CNV deletion 23128226
dgv7138n100 CNV gain 25217958

Variation tolerance for RHOBTB2 Gene

Residual Variation Intolerance Score: 9.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOBTB2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOBTB2 Gene

Disorders for RHOBTB2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RHOBTB2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acrodermatitis chronica atrophicans
  • herxheimer disease
sporadic breast cancer
  • sporadic breast carcinoma
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RHOBTB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RHOBTB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOBTB2 Gene

Publications for RHOBTB2 Gene

  1. Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants. (PMID: 26517842) Prince TL … Neckers L (PloS one 2015) 3 4 60
  2. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PMID: 19714462) Loizidou MA … Kyriacou K (Breast cancer research and treatment 2010) 3 45 60
  3. A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. (PMID: 19937980) Mao H … Zhang L (Molecular carcinogenesis 2010) 3 22 60
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 45 60
  5. Genetic analysis of the DBC2 gene in gastric cancer. (PMID: 17906984) Cho YG … Park WS (Acta oncologica (Stockholm, Sweden) 2008) 3 22 60

Products for RHOBTB2 Gene

Sources for RHOBTB2 Gene

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