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Aliases for RHOBTB1 Gene

Aliases for RHOBTB1 Gene

  • Rho Related BTB Domain Containing 1 2 3 5
  • Rho-Related BTB Domain Containing 1 2
  • KIAA0740 4

External Ids for RHOBTB1 Gene

Previous GeneCards Identifiers for RHOBTB1 Gene

  • GC10M061425
  • GC10M061654
  • GC10M062521
  • GC10M061973
  • GC10M062299
  • GC10M062629
  • GC10M056618

Summaries for RHOBTB1 Gene

Entrez Gene Summary for RHOBTB1 Gene

  • The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for RHOBTB1 Gene

RHOBTB1 (Rho Related BTB Domain Containing 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Ubiquitin mediated proteolysis. GO annotations related to this gene include GTP binding. An important paralog of this gene is RHOBTB2.

Gene Wiki entry for RHOBTB1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOBTB1 Gene

Genomics for RHOBTB1 Gene

Regulatory Elements for RHOBTB1 Gene

Enhancers for RHOBTB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F060977 1.3 Ensembl ENCODE 18.1 +22.6 22555 3.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B FEZF1 DMAP1 FOS SP3 JUNB RHOBTB1 RNU2-72P
GH10F060962 1.1 Ensembl ENCODE 18 +37.3 37279 3.2 ATF1 TBL1XR1 INSM2 SIN3A RAD21 RFX5 CHAMP1 ZNF366 ZNF143 FOS RHOBTB1 RNU2-72P
GH10F060847 1.1 Ensembl ENCODE 16.9 +152.9 152900 1.6 CTCF KLF1 ESRRA ZMYM3 RAD21 ZNF335 ZNF664 GATA3 ZFHX2 CTBP1 RHOBTB1 PIR54624 CDK1
GH10F060955 1.1 Ensembl ENCODE 16.8 +45.3 45306 1.8 ELF3 ARID4B FOS CREM MIXL1 THAP11 JUNB CEBPB MIER2 TBX21 RHOBTB1 RNU2-72P
GH10F060974 1 Ensembl ENCODE 18.3 +26.5 26517 1.3 PKNOX1 JUN INSM2 HIC1 ZNF366 ZNF207 FOS KLF8 ZNF362 ZFP37 RHOBTB1 RNU2-72P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOBTB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOBTB1 Gene

Chromosome:
10
Start:
60,869,438 bp from pter
End:
61,001,468 bp from pter
Size:
132,031 bases
Orientation:
Minus strand

Genomic View for RHOBTB1 Gene

Genes around RHOBTB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOBTB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOBTB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOBTB1 Gene

Proteins for RHOBTB1 Gene

  • Protein details for RHOBTB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94844-RHBT1_HUMAN
    Recommended name:
    Rho-related BTB domain-containing protein 1
    Protein Accession:
    O94844

    Protein attributes for RHOBTB1 Gene

    Size:
    696 amino acids
    Molecular mass:
    79417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RHOBTB1 Gene

Post-translational modifications for RHOBTB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RHOBTB1 Gene

Domains & Families for RHOBTB1 Gene

Gene Families for RHOBTB1 Gene

Suggested Antigen Peptide Sequences for RHOBTB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94844

UniProtKB/Swiss-Prot:

RHBT1_HUMAN :
  • Contains 2 BTB (POZ) domains.
  • Belongs to the small GTPase superfamily. Rho family.
Domain:
  • Contains 2 BTB (POZ) domains.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOBTB1: view

Function for RHOBTB1 Gene

Gene Ontology (GO) - Molecular Function for RHOBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOBTB1: view
genes like me logo Genes that share phenotypes with RHOBTB1: view

Animal Model Products

miRNA for RHOBTB1 Gene

miRTarBase miRNAs that target RHOBTB1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOBTB1 Gene

Localization for RHOBTB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOBTB1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RHOBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOBTB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RHOBTB1 Gene

Pathways & Interactions for RHOBTB1 Gene

genes like me logo Genes that share pathways with RHOBTB1: view

Pathways by source for RHOBTB1 Gene

3 Reactome pathways for RHOBTB1 Gene
1 KEGG pathway for RHOBTB1 Gene

Gene Ontology (GO) - Biological Process for RHOBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOBTB1: view

No data available for SIGNOR curated interactions for RHOBTB1 Gene

Transcripts for RHOBTB1 Gene

Unigene Clusters for RHOBTB1 Gene

Rho-related BTB domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - -
SP7: -
SP8: - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11:
SP12:
SP13: - - - - - - -
SP14: - - - - - - -
SP15:
SP16: -
SP17:
SP18: - -

ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RHOBTB1 Gene

GeneLoc Exon Structure for
RHOBTB1
ECgene alternative splicing isoforms for
RHOBTB1

Expression for RHOBTB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHOBTB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOBTB1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.0).

Protein differential expression in normal tissues from HIPED for RHOBTB1 Gene

This gene is overexpressed in Heart (61.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RHOBTB1 Gene



Protein tissue co-expression partners for RHOBTB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOBTB1 Gene:

RHOBTB1

SOURCE GeneReport for Unigene cluster for RHOBTB1 Gene:

Hs.737374

mRNA Expression by UniProt/SwissProt for RHOBTB1 Gene:

O94844-RHBT1_HUMAN
Tissue specificity: Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues.
genes like me logo Genes that share expression patterns with RHOBTB1: view

Primer Products

Orthologs for RHOBTB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOBTB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOBTB1 34 35
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia RHOBTB1 34 35
  • 89.08 (n)
dog
(Canis familiaris)
Mammalia RHOBTB1 34 35
  • 88.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RHOBTB1 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhobtb1 34
  • 83.36 (n)
mouse
(Mus musculus)
Mammalia Rhobtb1 34 16 35
  • 83.07 (n)
oppossum
(Monodelphis domestica)
Mammalia RHOBTB1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOBTB1 34 35
  • 76.31 (n)
lizard
(Anolis carolinensis)
Reptilia RHOBTB1 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhobtb1 34
  • 73.21 (n)
zebrafish
(Danio rerio)
Actinopterygii RHOBTB1 35
  • 74 (a)
OneToOne
rhobtb1 34
  • 69 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoBTB 35
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
ManyToMany
CSA.4181 35
  • 38 (a)
ManyToMany
Species where no ortholog for RHOBTB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOBTB1 Gene

ENSEMBL:
Gene Tree for RHOBTB1 (if available)
TreeFam:
Gene Tree for RHOBTB1 (if available)

Paralogs for RHOBTB1 Gene

Paralogs for RHOBTB1 Gene

(6) SIMAP similar genes for RHOBTB1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RHOBTB1: view

Variants for RHOBTB1 Gene

Sequence variations from dbSNP and Humsavar for RHOBTB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10082373 -- 60,886,727(+) GGGGG(G/T)GGGTC intron-variant
rs10082527 -- 60,886,718(+) GATGT(C/G/T)GGGGG intron-variant
rs10082528 -- 60,886,726(+) ggggg(G/T)tgggt intron-variant
rs1013704 -- 60,937,660(+) CCTTA(C/G)AGTGT intron-variant
rs1013705 -- 60,937,764(+) CCTTA(A/C)AATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOBTB1 Gene

Variant ID Type Subtype PubMed ID
esv2737496 CNV deletion 23290073
nsv1125176 CNV insertion 24896259

Variation tolerance for RHOBTB1 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOBTB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOBTB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOBTB1 Gene

Disorders for RHOBTB1 Gene

Relevant External Links for RHOBTB1

Genetic Association Database (GAD)
RHOBTB1
Human Genome Epidemiology (HuGE) Navigator
RHOBTB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOBTB1

No disorders were found for RHOBTB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOBTB1 Gene

Publications for RHOBTB1 Gene

  1. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 46 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. (PMID: 12426103) Ramos S. … Rivero F. (Gene 2002) 3 4 64

Products for RHOBTB1 Gene

Sources for RHOBTB1 Gene

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