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RHOBTB1 Gene

protein-coding   GIFtS: 54
GCID: GC10M062629

Rho-Related BTB Domain Containing 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho-Related BTB Domain Containing 11 2
KIAA07403 5
Rho-Related BTB Domain-Containing Protein 12

External Ids:    HGNC: 187381   Entrez Gene: 98862   Ensembl: ENSG000000724227   OMIM: 6073515   UniProtKB: O948443   

Export aliases for RHOBTB1 gene to outside databases

Previous GC identifers: GC10M061425 GC10M061654 GC10M062521 GC10M061973 GC10M062299 GC10M056618


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHOBTB1 Gene:
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase
domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a
conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the
organization of the actin filament system. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, Dec 2008)

GeneCards Summary for RHOBTB1 Gene:
RHOBTB1 (Rho-related BTB domain containing 1) is a protein-coding gene. Diseases associated with RHOBTB1 include alzheimer's disease. GO annotations related to this gene include GTP binding. An important paralog of this gene is RHOH.

Gene Wiki entry for RHOBTB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RHOBTB1 gene promoter:
         HFH-3   E2F-4   E2F-3a   E2F-5   E2F-2   FOXI1   E2F   E2F-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RHOBTB1 promoter sequence
   Search Chromatin IP Primers for RHOBTB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOBTB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.2   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q22.1

RHOBTB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOBTB1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M062629:  view genomic region     (about GC identifiers)

Start:
62,629,196 bp from pter      End:
62,761,198 bp from pter
Size:
132,003 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHBT1_HUMAN, O94844 (See protein sequence)
Recommended Name: Rho-related BTB domain-containing protein 1  
Size: 696 amino acids; 79417 Da

Explore the universe of human proteins at neXtProt for RHOBTB1: NX_O94844

Explore proteomics data for RHOBTB1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RHOBTB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229288.1  NP_055651.1  

    ENSEMBL proteins: 
     ENSP00000338671   ENSP00000350595  
    Reactome Protein details: O94844

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    Cloud-Clone Corp. CLIAs for RHOBTB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing

    Selected InterPro protein domains (see all 6):
     IPR003578 Small_GTPase_Rho
     IPR001806 Small_GTPase
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O94844

    ProtoNet protein and cluster: O94844

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHBT1_HUMAN, O94844
    Similarity: Belongs to the small GTPase superfamily. Rho family
    Similarity: Contains 2 BTB (POZ) domains


    RHOBTB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
         
    RHOBTB1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHOBTB1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOBTB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOBTB1

    miRNA
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    miRTarBase miRNAs that target RHOBTB1:
    hsa-mir-26a-5p (MIRT050128), hsa-mir-335-5p (MIRT018495)

    Block miRNA regulation of human, mouse, rat RHOBTB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOBTB1 (see all 36):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-200a hsa-miR-29a hsa-miR-218 hsa-miR-141 hsa-miR-9 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOBTB1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RHOBTB1
    Predesigned siRNA for gene silencing in human, mouse, rat RHOBTB1

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    GenScript: all cDNA clones in your preferred vector: RHOBTB1 (NM_014836)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOBTB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOBTB1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for RHOBTB1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    RHOBTB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOBTB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RHOBTB1
        Rho GTPase cycle


    1 Kegg Pathway  (Kegg details for RHOBTB1):
        Ubiquitin mediated proteolysis


    RHOBTB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RHOBTB1: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RHOBTB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOBTB1 (O948443 ENSP000003386714) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR1BO002383I2D: score=2 
    TGFBR1P368973I2D: score=2 
    ACVR1Q047713I2D: score=1 
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport ----
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    RHOBTB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOBTB1 (RHBT1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RHOBTB1 gene (2 alternative transcripts): 
    NM_001242359.1  NM_014836.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337910(uc001jli.3 uc001jlh.3) ENST00000357917(uc009xpd.3 uc009xpe.2 uc001jlj.3 uc001jlk.3 uc001jlm.3)
    ENST00000496237 ENST00000461910 ENST00000490827 ENST00000483488
    miRNA
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    Block miRNA regulation of human, mouse, rat RHOBTB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOBTB1 (see all 36):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-200a hsa-miR-29a hsa-miR-218 hsa-miR-141 hsa-miR-9 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOBTB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RHOBTB1
    Predesigned siRNA for gene silencing in human, mouse, rat RHOBTB1
    Clone
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    OriGene clones in human, mouse for RHOBTB1 (see all 14)
    OriGene ORF clones in mouse, rat for RHOBTB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOBTB1 (NM_014836)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOBTB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOBTB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOBTB1
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOBTB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOBTB1
      QuantiTect SYBR Green Assays in human, mouse, rat RHOBTB1
      QuantiFast Probe-based Assays in human, mouse, rat RHOBTB1

    Selected AceView cDNA sequences (see all 178):

    BQ672498 NM_198225 AW612138 BQ574439 BF724865 BC032848 NM_014836 BU734028 
    AI566750 BC041791 AI537286 AI984363 BU624790 BQ674810 AK075129 BQ183464 
    BM692726 BX500011 CD642382 BF197532 BX397555 AB018283 AA404558 AI566009 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB1 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a ·
    SP1:        -     -           -     -     -     -                 -                 -                       -     -                                             
    SP2:                                                                                -                       -     -                                             
    SP3:                                                              -                 -                       -     -                                             
    SP4:        -     -           -     -     -     -                                                                                                               
    SP5:        -     -           -     -     -     -     -     -     -                 -                       -     -                                             

    ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
    SP1:        -                                 
    SP2:        -                                 
    SP3:        -                                 
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for RHOBTB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOBTB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTTTGTT
    RHOBTB1 Expression
    About this image


    RHOBTB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    RHOBTB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOBTB1 Protein Expression

    UniProtKB/Swiss-Prot: RHBT1_HUMAN, O94844
    Tissue specificity: Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney,
    followed by uterus and adrenal gland. Expressed in a variety of fetal tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including RHOBTB1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOBTB1
    QuantiTect SYBR Green Assays in human, mouse, rat RHOBTB1
    QuantiFast Probe-based Assays in human, mouse, rat RHOBTB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOBTB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RHOBTB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhobtb11 , 5 Rho-related BTB domain containing 11, 5 83.07(n)1
    88.92(a)1
      10 (36.04 cM)5
    692881  NM_001252637.11  NP_001239566.11 
     691514345 
    chicken
    (Gallus gallus)
    Aves RHOBTB11 Rho-related BTB domain containing 1 76.31(n)
    83.21(a)
      423664  NM_001199608.1  NP_001186537.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOBTB16
    Rho-related BTB domain containing 1
    82(a)
    1 ↔ 1
    GL343204.1(3932421-4009127)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480606702   -- 77.46(n)    48060670 
    zebrafish
    (Danio rerio)
    Actinopterygii rhobtb11 Rho-related BTB domain containing 1 69(n)
    74.78(a)
      100537290  XM_003199567.2  XP_003199615.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoBTB6
    RhoBTB
    39(a)
    1 → many
    3L(20369342-20375498)


    ENSEMBL Gene Tree for RHOBTB1 (if available)
    TreeFam Gene Tree for RHOBTB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOBTB1 gene
    RHOH2  RHOQ2  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    6 SIMAP similar genes for RHOBTB1 using alignment to 2 protein entries:     RHBT1_HUMAN (see all proteins):
    RHOBTB2    RHOA    RHOC    CDC42    RHOB    RHOV

    RHOBTB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOBTB1 (see all 2686)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30494521,2
    C--56745909(-) gtgtg-/TGTACAT 2 -- int11Minor allele frequency- TG:0.00NA 2
    rs1447835451,2
    C--62628699(+) AAAAGC/TCCCTC 4 -- ds50010--------
    rs1485476031,2
    --62628753(+) ACATTG/TTATTA 4 -- ds50010--------
    rs1853310831,2
    --62628900(+) TAAGTA/CCTGTA 4 -- ds50010--------
    rs1418973221,2
    C--62628932(+) CAACCC/TGCTCT 4 -- ds50010--------
    rs1898461821,2
    --62629084(+) TACTGC/GAGCAT 4 -- ds50010--------
    rs1137838151,2
    C,F--62629164(+) CAATAT/CGATGT 4 -- ds50012Minor allele frequency- C:0.06NA 122
    rs1835469991,2
    --62629346(+) CTTATA/TCCCCA 4 -- ut31 nc-transcript-variant0--------
    rs1400352901,2
    --62629391(+) TTACAA/GTCAAA 4 -- ut31 nc-transcript-variant0--------
    rs1886774031,2
    --62629524(+) GATTTA/CCAAGC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for RHOBTB1 (62629196 - 62761198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RHOBTB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737496CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607351    OMIM disorders: --

    1 disease for RHOBTB1:    
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    alzheimer's disease


    RHOBTB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RHOBTB1
    Human Genome Epidemiology (HuGE) Navigator: RHOBTB1 (1 document)

    Export disorders for RHOBTB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOBTB1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RHOBTB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. (PubMed id 12426103)1, 2 Ramos S.... Rivero F. (Gene 2002)
    6. The Dictyostelium discoideum family of Rho-related proteins. (PubMed id 11222756)1, 3 Rivero F....Noegel A.A. (Nucleic Acids Res. 2001)
    7. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    8. The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. (PubMed id 23258531)1 Xu R.S....Zhang B. (Int. J. Oncol. 2013)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARI^ and RhoA/Rho-kinase. (PubMed id 23040068)1 Pelham C.J....Sigmund C.D. (Cell Metab. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9886 HGNC: 18738 AceView: RHOBTB1 Ensembl:ENSG00000072422 euGenes: HUgn9886
    ECgene: RHOBTB1 Kegg: 9886 H-InvDB: RHOBTB1

    (According to HUGE)
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    HUGE: KIAA0740

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHOBTB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOBTB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHOBTB1 gene:
    Search GeneIP for patents involving RHOBTB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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