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Aliases for RHOBTB1 Gene

Aliases for RHOBTB1 Gene

  • Rho-Related BTB Domain Containing 1 2 3
  • KIAA0740 4 6

External Ids for RHOBTB1 Gene

Summaries for RHOBTB1 Gene

Entrez Gene Summary for RHOBTB1 Gene

  • The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for RHOBTB1 Gene

RHOBTB1 (Rho-Related BTB Domain Containing 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAC2.

Gene Wiki entry for RHOBTB1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOBTB1 Gene

Genomics for RHOBTB1 Gene

Genomic Location for RHOBTB1 Gene

Start:
60,869,438 bp from pter
End:
61,001,440 bp from pter
Size:
132,003 bases
Orientation:
Minus strand

Genomic View for RHOBTB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOBTB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOBTB1 Gene

Regulatory Elements for RHOBTB1 Gene

Proteins for RHOBTB1 Gene

  • Protein details for RHOBTB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94844-RHBT1_HUMAN
    Recommended name:
    Rho-related BTB domain-containing protein 1
    Protein Accession:
    O94844
    Secondary Accessions:

    Protein attributes for RHOBTB1 Gene

    Size:
    696 amino acids
    Molecular mass:
    79417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RHOBTB1 Gene

Proteomics data for RHOBTB1 Gene at MOPED

Post-translational modifications for RHOBTB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOBTB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOBTB1 Gene

Domains for RHOBTB1 Gene

Gene Families for RHOBTB1 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Suggested Antigen Peptide Sequences for RHOBTB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94844

UniProtKB/Swiss-Prot:

RHBT1_HUMAN
Domain:
  • Contains 2 BTB (POZ) domains.:
    • O94844
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • O94844
genes like me logo Genes that share domains with RHOBTB1: view

Function for RHOBTB1 Gene

Gene Ontology (GO) - Molecular Function for RHOBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOBTB1: view

miRNA for RHOBTB1 Gene

miRTarBase miRNAs that target RHOBTB1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RHOBTB1 Gene

Localization for RHOBTB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOBTB1 Gene COMPARTMENTS Subcellular localization image for RHOBTB1 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RHOBTB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RHOBTB1 Gene

Pathways for RHOBTB1 Gene

genes like me logo Genes that share pathways with RHOBTB1: view

Pathways by source for RHOBTB1 Gene

3 Reactome pathways for RHOBTB1 Gene
1 KEGG pathway for RHOBTB1 Gene

Gene Ontology (GO) - Biological Process for RHOBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0015031 protein transport --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOBTB1: view

Transcripts for RHOBTB1 Gene

Unigene Clusters for RHOBTB1 Gene

Rho-related BTB domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - -
SP7: -
SP8: - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11:
SP12:
SP13: - - - - - - -
SP14: - - - - - - -
SP15:
SP16: -
SP17:
SP18: - -

ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RHOBTB1 Gene

GeneLoc Exon Structure for
RHOBTB1
ECgene alternative splicing isoforms for
RHOBTB1

Expression for RHOBTB1 Gene

mRNA expression in normal human tissues for RHOBTB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOBTB1 Gene

This gene is overexpressed in Muscle - Skeletal (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RHOBTB1 Gene

SOURCE GeneReport for Unigene cluster for RHOBTB1 Gene Hs.737374

mRNA Expression by UniProt/SwissProt for RHOBTB1 Gene

O94844-RHBT1_HUMAN
Tissue specificity: Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues.
genes like me logo Genes that share expressions with RHOBTB1: view

Orthologs for RHOBTB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOBTB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOBTB1 35
  • 99.38 (n)
  • 99.43 (a)
RHOBTB1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOBTB1 35
  • 89.08 (n)
  • 93.82 (a)
RHOBTB1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOBTB1 35
  • 88.7 (n)
  • 92.53 (a)
RHOBTB1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhobtb1 35
  • 83.07 (n)
  • 88.92 (a)
Rhobtb1 16
Rhobtb1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOBTB1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOBTB1 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhobtb1 35
  • 83.36 (n)
  • 88.92 (a)
chicken
(Gallus gallus)
Aves RHOBTB1 35
  • 76.31 (n)
  • 83.21 (a)
RHOBTB1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOBTB1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhobtb1 35
  • 73.21 (n)
  • 80.96 (a)
zebrafish
(Danio rerio)
Actinopterygii rhobtb1 35
  • 69 (n)
  • 74.78 (a)
RHOBTB1 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoBTB 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
ManyToMany
CSA.4181 36
  • 38 (a)
ManyToMany
Species with no ortholog for RHOBTB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOBTB1 Gene

ENSEMBL:
Gene Tree for RHOBTB1 (if available)
TreeFam:
Gene Tree for RHOBTB1 (if available)

Paralogs for RHOBTB1 Gene

Paralogs for RHOBTB1 Gene

Selected SIMAP similar genes for RHOBTB1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RHOBTB1: view

Variants for RHOBTB1 Gene

Sequence variations from dbSNP and Humsavar for RHOBTB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs15700 -- 60,871,570(-) GAAAA(A/G)GGAAC missense, reference, nc-transcript-variant, utr-variant-3-prime, downstream-variant-500B
rs750593 -- 60,902,556(-) CCTTT(C/G/T)GTGAA intron-variant
rs873602 -- 61,002,079(-) ACCAT(A/G)TGTAA upstream-variant-2KB
rs884403 -- 60,898,101(-) ACATA(C/T)AAAGA intron-variant
rs884404 -- 60,898,080(-) TACCA(C/T)GGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOBTB1 Gene

Variant ID Type Subtype PubMed ID
esv2737496 CNV Deletion 23290073

Relevant External Links for RHOBTB1 Gene

HapMap Linkage Disequilibrium report
RHOBTB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOBTB1 Gene

Disorders for RHOBTB1 Gene

Relevant External Links for RHOBTB1

Genetic Association Database (GAD)
RHOBTB1
Human Genome Epidemiology (HuGE) Navigator
RHOBTB1
genes like me logo Genes that share disorders with RHOBTB1: view

No data available for UniProtKB/Swiss-Prot for RHOBTB1 Gene

Publications for RHOBTB1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. The Dictyostelium discoideum family of Rho-related proteins. (PMID: 11222756) Rivero F. … Noegel A.A. (Nucleic Acids Res. 2001) 2 3
  3. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. (PMID: 12426103) Ramos S. … Rivero F. (Gene 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RHOBTB1 Gene

Sources for RHOBTB1 Gene

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