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Aliases for RHOBTB1 Gene

Aliases for RHOBTB1 Gene

  • Rho Related BTB Domain Containing 1 2 3
  • Rho-Related BTB Domain Containing 1 2 5
  • KIAA0740 4

External Ids for RHOBTB1 Gene

Previous GeneCards Identifiers for RHOBTB1 Gene

  • GC10M061425
  • GC10M061654
  • GC10M062521
  • GC10M061973
  • GC10M062299
  • GC10M062629
  • GC10M056618

Summaries for RHOBTB1 Gene

Entrez Gene Summary for RHOBTB1 Gene

  • The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for RHOBTB1 Gene

RHOBTB1 (Rho Related BTB Domain Containing 1) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Signaling by Rho GTPases. GO annotations related to this gene include GTP binding. An important paralog of this gene is RHOA.

Gene Wiki entry for RHOBTB1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOBTB1 Gene

Genomics for RHOBTB1 Gene

Regulatory Elements for RHOBTB1 Gene

Enhancers for RHOBTB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RHOBTB1 on UCSC Golden Path with GeneCards custom track

Promoters for RHOBTB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHOBTB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOBTB1 Gene

60,869,438 bp from pter
61,001,468 bp from pter
132,031 bases
Minus strand

Genomic View for RHOBTB1 Gene

Genes around RHOBTB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOBTB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOBTB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOBTB1 Gene

Proteins for RHOBTB1 Gene

  • Protein details for RHOBTB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related BTB domain-containing protein 1
    Protein Accession:

    Protein attributes for RHOBTB1 Gene

    696 amino acids
    Molecular mass:
    79417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RHOBTB1 Gene

Proteomics data for RHOBTB1 Gene at MOPED

Post-translational modifications for RHOBTB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOBTB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOBTB1 Gene

Domains & Families for RHOBTB1 Gene

Gene Families for RHOBTB1 Gene

Suggested Antigen Peptide Sequences for RHOBTB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 BTB (POZ) domains.
  • Belongs to the small GTPase superfamily. Rho family.
  • Contains 2 BTB (POZ) domains.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOBTB1: view

Function for RHOBTB1 Gene

genes like me logo Genes that share phenotypes with RHOBTB1: view

Animal Model Products

CRISPR Products

miRNA for RHOBTB1 Gene

miRTarBase miRNAs that target RHOBTB1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOBTB1 Gene

Localization for RHOBTB1 Gene

Subcellular locations from

Jensen Localization Image for RHOBTB1 Gene COMPARTMENTS Subcellular localization image for RHOBTB1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOBTB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RHOBTB1 Gene

Pathways & Interactions for RHOBTB1 Gene

genes like me logo Genes that share pathways with RHOBTB1: view

Pathways by source for RHOBTB1 Gene

3 Reactome pathways for RHOBTB1 Gene
1 KEGG pathway for RHOBTB1 Gene

Gene Ontology (GO) - Biological Process for RHOBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOBTB1: view

No data available for SIGNOR curated interactions for RHOBTB1 Gene

Drugs & Compounds for RHOBTB1 Gene

No Compound Related Data Available

Transcripts for RHOBTB1 Gene

Unigene Clusters for RHOBTB1 Gene

Rho-related BTB domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOBTB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - -
SP7: -
SP8: - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP16: -
SP18: - -

ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2: -
SP3: -
SP11: - -
SP12: - - -

Relevant External Links for RHOBTB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOBTB1 Gene

mRNA expression in normal human tissues for RHOBTB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOBTB1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.0).

Protein differential expression in normal tissues from HIPED for RHOBTB1 Gene

This gene is overexpressed in Heart (61.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RHOBTB1 Gene

SOURCE GeneReport for Unigene cluster for RHOBTB1 Gene Hs.737374

mRNA Expression by UniProt/SwissProt for RHOBTB1 Gene

Tissue specificity: Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues.
genes like me logo Genes that share expression patterns with RHOBTB1: view

Protein tissue co-expression partners for RHOBTB1 Gene

Primer Products

Orthologs for RHOBTB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOBTB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RHOBTB1 35
  • 89.08 (n)
  • 93.82 (a)
  • 94 (a)
(Canis familiaris)
Mammalia RHOBTB1 35
  • 88.7 (n)
  • 92.53 (a)
  • 93 (a)
(Mus musculus)
Mammalia Rhobtb1 35
  • 83.07 (n)
  • 88.92 (a)
Rhobtb1 16
Rhobtb1 36
  • 89 (a)
(Pan troglodytes)
Mammalia RHOBTB1 35
  • 99.38 (n)
  • 99.43 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rhobtb1 35
  • 83.36 (n)
  • 88.92 (a)
(Monodelphis domestica)
Mammalia RHOBTB1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia RHOBTB1 36
  • 86 (a)
(Gallus gallus)
Aves RHOBTB1 35
  • 76.31 (n)
  • 83.21 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia RHOBTB1 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhobtb1 35
  • 73.21 (n)
  • 80.96 (a)
(Danio rerio)
Actinopterygii rhobtb1 35
  • 69 (n)
  • 74.78 (a)
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoBTB 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
CSA.4181 36
  • 38 (a)
Species with no ortholog for RHOBTB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOBTB1 Gene

Gene Tree for RHOBTB1 (if available)
Gene Tree for RHOBTB1 (if available)

Paralogs for RHOBTB1 Gene

Paralogs for RHOBTB1 Gene

(6) SIMAP similar genes for RHOBTB1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RHOBTB1: view

Variants for RHOBTB1 Gene

Sequence variations from dbSNP and Humsavar for RHOBTB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs15700 -- 60,871,570(-) GAAAA(A/G)GGAAC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1864756 -- 60,949,804(-) AAAAG(A/T)ACACA intron-variant
rs1864757 -- 60,949,689(-) GCTTT(A/T)AAAAA intron-variant
rs1864763 -- 60,916,923(+) TGAAG(A/T)TGCTA intron-variant
rs1864764 -- 60,917,222(+) TGTTT(A/G)TTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOBTB1 Gene

Variant ID Type Subtype PubMed ID
esv2737496 CNV Deletion 23290073

Variation tolerance for RHOBTB1 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RHOBTB1 Gene

Disorders for RHOBTB1 Gene

Relevant External Links for RHOBTB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RHOBTB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOBTB1 Gene

Publications for RHOBTB1 Gene

  1. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 48 67
  2. The Dictyostelium discoideum family of Rho-related proteins. (PMID: 11222756) Rivero F. … Noegel A.A. (Nucleic Acids Res. 2001) 2 3
  3. Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. (PMID: 26100637) Ibeawuchi S.R. … Sigmund C.D. (J. Biol. Chem. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RHOBTB1 Gene

Sources for RHOBTB1 Gene