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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOB Gene

protein-coding   GIFtS: 64
GCID: GC02P020568

Ras Homolog Family Member B

(Previous names: ras homolog gene family, member B)
(Previous symbols: ARH6, ARHB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Homolog Family Member B1 2     h62 3
ARH61 2 3 5     RHOH62 5
ARHB1 2 3 5     MST0812
Ras Homolog Gene Family, Member B1 2     MSTP0812
Oncogene RHO H61 2     Aplysia RAS-Related Homolog 62
Rho CDNA Clone 62 3     Rho-Related GTP-Binding Protein RhoB2

External Ids:    HGNC: 6681   Entrez Gene: 3882   Ensembl: ENSG000001438787   OMIM: 1653705   UniProtKB: P627453   

Export aliases for RHOB gene to outside databases

Previous GC identifers: GC02P020632 GC02P020510 GC02P020404


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RHOB Gene: 
RHOB (ras homolog family member B) is a protein-coding gene. Diseases associated with RHOB include vesiculitis, and sertoli cell-only syndrome, and among its related super-pathways are Signaling by GPCR and Sema4D in semaphorin signaling. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development
but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in
tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of
proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to
lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell
survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin
contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in
breast cancer cells

Gene Wiki entry for RHOB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_015926.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOB gene promoter:
         CREB   GR   AP-1   deltaCREB   ATF-2   AP-2beta   GR-alpha   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RHOB promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24

RHOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P020568:  view genomic region     (about GC identifiers)

Start:
20,646,835 bp from pter      End:
20,649,201 bp from pter
Size:
2,367 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoB precursor  
Size: 196 amino acids; 22123 Da
Subunit: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13
Subcellular location: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow.
Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the
nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a
ECT2-dependent manner
Miscellaneous: RHOB is one of the targets of farnesyltransferase inhibitors which are currently under
investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause
mislocalization, leading to apoptosis and antineoplastic effects
1 PDB 3D structure from and Proteopedia for RHOB:
2FV8 (3D)    
Secondary accessions: B2R692 P01121 Q5U0H6 Q7RTN5 Q7RTR9 Q9CUV7

Explore the universe of human proteins at neXtProt for RHOB: NX_P62745

Explore proteomics data for RHOB at MOPED 

Post-translational modifications:

  • UniProtKB: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane
    while the geranylgeranylated form is localized to the endosome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62745

  • RHOB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOB Protein Expression
    REFSEQ proteins: NP_004031.1  
    ENSEMBL proteins: 
     ENSP00000272233  
    Reactome Protein details: P62745
    Human Recombinant Protein Products for RHOB: 
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    ProSpec Recombinant Protein for RHOB
    Cloud-Clone Corp. Proteins for RHOB 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IDA15226397

    RHOB for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for RHOB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P62745

    ProtoNet protein and cluster: P62745

    UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOB_HUMAN, P62745
    Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development
    but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in
    tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of
    proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to
    lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell
    survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin
    contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in
    breast cancer cells
    Induction: Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS3888408
    GO:0005515protein binding IPI19637314
    GO:0005525GTP binding TAS1400319
    GO:0019003GDP binding IEA--
         
    RHOB for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhob):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  tumorigenesis 
     vision/eye 

    RHOB for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOB 

    miRNA
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    miRTarBase miRNAs that target RHOB:
    hsa-let-7b (MIRT001599), hsa-mir-21 (MIRT003317), hsa-mir-223 (MIRT001109)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOB
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOB (see all 31):
    hsa-miR-411* hsa-miR-30c hsa-miR-379* hsa-miR-4328 hsa-let-7a-2* hsa-miR-624* hsa-miR-30d hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidRHOB 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHOB About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Sema4D in semaphorin signaling
    Sema4D in semaphorin signaling0.89
    Semaphorin interactions0.41
    Sema4D induced cell migration and growth-cone collapse0.89
    3Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    4Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    5Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RHOB
        G-protein signaling RhoB regulation pathway

    1 R&D Systems Pathway for RHOB
        Wnt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for RHOB
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RHOB
        G-protein signaling RhoB regulation pathway

    4 BioSystems Pathways for RHOB
        Focal Adhesion
    Spinal Cord Injury
    Neural Crest Differentiation
    Androgen receptor signaling pathway

    5/14        Reactome Pathways for RHOB (see all 14)
        GPCR downstream signaling
    Hemostasis
    Signaling by Rho GTPases
    Developmental Biology
    G alpha (12/13) signalling events



    RHOB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/110 Interacting proteins for RHOB (P627451, 2, 3 ENSP000002722334) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFAIP1Q138291, 3, ENSP000002262254EBI-602647,EBI-2505861 I2D: score=2 STRING: ENSP00000226225
    INSRP062132, 3, ENSP000003038304MINT-6800491 I2D: score=1 STRING: ENSP00000303830
    PTPN1P180312, 3, ENSP000003606834MINT-6800506 I2D: score=1 STRING: ENSP00000360683
    ARHGDIGQ998193, ENSP000002194094I2D: score=2 STRING: ENSP00000219409
    ARHGEF3Q9NR813, ENSP000003410714I2D: score=2 STRING: ENSP00000341071
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP16236794
    GO:0001525angiogenesis IEA--
    GO:0006184GTP catabolic process TAS3888408
    GO:0006915apoptotic process TAS19637314
    GO:0006927transformed cell apoptotic process ISS--

    RHOB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOB

    1 DrugBank Compound for RHOB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Botulinum Toxin Type ABoNT/A (see all 4)93384-43-1target--15140914

    10/18 Novoseek inferred chemical compound relationships for RHOB gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azatyrosine 80.8 1 10667209 (1)
    geranylgeranyl pyrophosphate 56.4 7 12427032 (2), 12384510 (1), 19151402 (1)
    mevalonate 50.9 8 11788600 (2), 12384510 (2), 12427032 (2), 19151402 (1)
    lovastatin 43.1 10 19151402 (6), 12235235 (3), 10440923 (1)
    gtp 41.3 15 8939998 (3), 18377644 (3), 17198702 (1), 11918088 (1)
    gdp 34.9 6 8939998 (3)
    actinomycin d 21.6 3 16909123 (1), 11788600 (1), 19151402 (1)
    cycloheximide 13.2 1 19151402 (1)
    paclitaxel 8.18 2 16101130 (1), 11353846 (1)
    methionine 7.2 1 16170025 (1)

    Search CenterWatch for drugs/clinical trials and news about RHOB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHOB gene: 
    NM_004040.2  

    Unigene Cluster for RHOB:

    Ras homolog family member B
    Hs.502876  [show with all ESTs]
    Unigene Representative Sequence: NM_004040
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000272233(uc002rdv.3)
    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOB (see all 31):
    hsa-miR-411* hsa-miR-30c hsa-miR-379* hsa-miR-4328 hsa-let-7a-2* hsa-miR-624* hsa-miR-30d hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidRHOB 3' UTR sequence
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    Additional mRNA sequence: 

    AF171089.1 AF498971.1 AK124398.1 AK297495.1 AK309991.1 AK310813.1 AK312487.1 BC062781.1 
    BC066954.1 BT019546.1 BT019547.1 CR542272.1 M12174.1 X06820.1 

    20 DOTS entries:

    DT.92327084  DT.92339462  DT.92033160  DT.120991656  DT.120991663  DT.95377224  DT.220260  DT.91778836 
    DT.100798162  DT.91778826  DT.95376747  DT.100798160  DT.91778839  DT.100798158  DT.87018075  DT.91778835 
    DT.91852109  DT.95377285  DT.100798169  DT.40115663 

    24/864 AceView cDNA sequences (see all 864):

    F35779 AI262065 AI419186 BM686281 CF453947 AI202155 AI246775 AW103688 
    H88963 BU950449 AA629787 AA182813 AW300351 AI650512 AI091225 AI361343 
    BF001832 AI926491 BM825718 AI796523 BQ288010 AI597826 AI143252 AI262977 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOB expression in normal human tissues (normalized intensities)      RHOB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACAGTTT
    RHOB Expression
    About this image


    RHOB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Septum   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived endothelial progenitor cells
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
     
     Umbilical Cord (Extraembryonic Tissues)
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells

    See RHOB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOB

    SOURCE GeneReport for Unigene cluster: Hs.502876
        SABiosciences Expression via Pathway-Focused PCR Arrays including RHOB: 
              Cancer Drug Targets in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Cell Motility in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOB gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhob1 , 5 ras homolog gene family, member B1, 5 94.9(n)1
    100(a)1
      12 (3.88 cM)5
    118521  NM_007483.21  NP_031509.11 
     84977635 
    chicken
    (Gallus gallus)
    Aves RHOB1 ras homolog gene family, member B 90.31(n)
    97.45(a)
      395734  NM_204909.1  NP_990240.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOB6
    Uncharacterized protein
    93(a)
    1 ↔ 1
    1(155258630-155259223)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.75192 Transcribed sequence with moderate similarity to protein spP01121 (H.sapiens) RHOB_HUMAN TRANSFORMING PROTEIN RHOB (H6) less 87.57(n)    CF153261.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rhoaa1 ras homolog gene family, member Aa 72.66(n)
    86.24(a)
      406411  NM_213137.1  NP_998302.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rho16
    Rho1
    82(a)
    1 → many
    2R(11990191-11994734)
    worm
    (Caenorhabditis elegans)
    Secernentea rho-16
    Ras-like GTP-binding protein rhoA
    80(a)
    1 → many
    IV(16483211-16489021)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHO16
    GTP-binding protein of the rho subfamily of Ras-li...
    61(a)
    1 → many
    XVI(875368-875997)


    ENSEMBL Gene Tree for RHOB (if available)
    TreeFam Gene Tree for RHOB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOB gene
    RHOA2  RND12  RHOD2  RHOF2  RHOC2  ENSG000002718102  RND22  RND32  
    18/54 SIMAP similar genes for RHOB using alignment to 1 protein entry:     RHOB_HUMAN(see all similar genes):
    RHOA    RHOC    ARHA    ARHE    RHOD    RND3
    RHOF    CDC42    RND2    ARHG    RHOG    RHOU
    RAC3    RHOV    RHOJ    RHOQ    RAC1    RAC2

    RHOB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/140 SNPs in RHOB are shown (see all 140)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406329531,2
    C--20645076(+) TGCCAC/GGCATT 1 -- us2k10--------
    rs759070851,2
    C,F--20645109(+) AGATAA/GGACAG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1924783681,2
    --20645279(+) TTTAGC/TACTCA 1 -- us2k10--------
    rs1499799501,2
    C--20645294(+) CCCCAC/GCATAT 1 -- us2k10--------
    rs1119213381,2
    C,F--20645456(+) TCACCG/TGTACT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1858445621,2
    --20645482(+) ATCTAA/CAGGAT 1 -- us2k10--------
    rs26021601,2
    C,F,A,H--20645506(-) TGCACA/GCCAGG 1 -- us2k126Minor allele frequency- G:0.18NS EA NA WA CSA 2358
    rs1891046551,2
    --20645653(+) GAACCC/GGGAAT 1 -- us2k10--------
    rs29243781,2
    C,A,H--20645666(-) TAGAAT/CGTACA 1 -- us2k111Minor allele frequency- C:0.19NA WA CSA EA 372
    rs124640171,2
    H--20645733(+) TTGTAC/TATTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHOB (20646835 - 20649201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RHOB:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv56n68CNV Loss17160897
    esv29979CNV Loss17803354
    nsv455830CNV Loss19166990
    nsv482049CNV Gain20164927
    dgv4068n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): RHOB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOB
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165370    OMIM disorders: --

    20/33 diseases for RHOB (see all 33):    About MalaCards
    vesiculitis    sertoli cell-only syndrome    tangier disease    traumatic brain injury
    clear cell renal cell carcinoma    blastoma    brain injury    cerebral infarction
    pancreatic ductal adenocarcinoma    stomatitis    myotonic dystrophy    renal cell carcinoma
    thyroid cancer    fibrosarcoma    osteoarthritis    spasticity
    cerebritis    thyroiditis    adenocarcinoma    lung cancer


    RHOB for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for RHOB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 30.6 29 15102679 (4), 18340357 (3), 11918088 (3), 19602596 (2) (see all 16)
    cancer 25.8 12 15102679 (2), 14647415 (2), 16909123 (2), 19637314 (1) (see all 7)
    cancer lung 21.3 21 15102679 (5), 18047684 (4), 19602596 (2), 11641777 (1) (see all 6)
    neoplastic transformation 19.4 1 12706111 (1)
    nsclc 14.9 13 17096327 (6)
    ovarian cancer 11.4 5 16796923 (3), 18340357 (2)
    metastasis 8.27 2 12939257 (1), 16909123 (1)
    adenocarcinoma 4.08 4 17096327 (2), 15102679 (1)
    necrosis 0 1 11062238 (1)
    carcinoma 0 1 15102679 (1)

    Genetic Association Database (GAD): RHOB
    Human Genome Epidemiology (HuGE) Navigator: RHOB (4 documents)

    Export disorders for RHOB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOB gene, integrated from 9 sources (see all 197):
    (articles sorted by number of sources associating them with RHOB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coding sequence of human rho cDNAs clone 6 and clone 9. (PubMed id 3283705)1, 2, 3 Chardin P.... Tavitian A. (1988)
    2. RhoB protects human keratinocytes from UVB-induced ap optosis through epidermal growth factor receptor signaling. (PubMed id 16278215)1, 3, 9 Canguilhem B....Favre G. (2005)
    3. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096)1, 2, 9 Arthur W.T.... Wennerberg K. (2002)
    4. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. (PubMed id 7713879)1, 2, 9 Armstrong S.A.... Brown M.S. (1995)
    5. PRK1 is targeted to endosomes by the small GTPase, RhoB. (PubMed id 9478917)1, 2, 9 Mellor H.... Parker P.J. (1998)
    6. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. (PubMed id 21373644)1, 2 Srougi M.C. and Burridge K. (2011)
    7. Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. (PubMed id 21750679)1, 4 Allanore Y....Martinez M. (2011)
    8. Field synopsis and synthesis of genetic association s tudies in osteoarthritis: the CUMAGAS-OSTEO information system. (PubMed id 20237151)1, 4 Zintzaras E....Karachalios T. (2010)
    9. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    10. Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis. (PubMed id 18471322)1, 4 Shi D....Jiang Q. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388 HGNC: 668 AceView: RHOB Ensembl:ENSG00000143878 euGenes: HUgn388
    ECgene: RHOB H-InvDB: RHOB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHOB gene:
    Search GeneIP for patents involving RHOB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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