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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOB Gene

protein-coding   GIFtS: 62
GCID: GC02P020568

ras homolog family member B

(Previous names: ras homolog gene family, member B )
(Previous symbols: ARH6, ARHB)
 Explore 34 diseases affiliated with
RHOB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RHOB    

Aliases
for RHOB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ras Homolog Family Member B1 2     H61
ARH61 2 3 5     RhoB1
ARHB1 2 3 5     MSTP0812
RHOH61 2 5     Aplysia RAS-Related Homolog 62
MST0811 2     Oncogene RHO H62
Ras Homolog Gene Family, Member B1 2     Rho-Related GTP-Binding Protein RhoB2
Rho CDNA Clone 62 3     

External Ids:    HGNC: 6681   Entrez Gene: 3882   Ensembl: ENSG000001438787   OMIM: 1653705   UniProtKB: P627453   

Export aliases for RHOB gene to outside databases

Previous GC identifers: GC02P020632 GC02P020510 GC02P020404


Summaries
for RHOB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but
affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as
deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1
to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for
stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle
cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells

Gene Wiki entry for RHOB


Genomic Views
for RHOB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_015926.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOB gene promoter:
         CREB   GR   AP-1   deltaCREB   ATF-2   AP-2beta   GR-alpha   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RHOB promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24

RHOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P020568:  view genomic region     (about GC identifiers)

Start:
 20,646,835 bp from pter      End:
 20,649,201 bp from pter
Size:
 2,367 bases      Orientation:
 plus strand

Proteins
for RHOB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoB precursor  
Size: 196 amino acids; 22123 Da
Subunit: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13
Subcellular location: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow.
Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the
nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent
manner
Miscellaneous: RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as
cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to
apoptosis and antineoplastic effects
1 PDB 3D structure from and Proteopedia for RHOB:
2FV8 (3D)    
Secondary accessions: B2R692 P01121 Q5U0H6 Q7RTN5 Q7RTR9 Q9CUV7

Explore the universe of human proteins at neXtProt for RHOB: NX_P62745

Post-translational modifications:

  • Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while
    • the geranylgeranylated form is localized to the endosome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62745

    • RHOB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004031.1  
    ENSEMBL proteins: 
     ENSP00000272233  
    Reactome Protein details: P62745
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals RHOB Proteins
    Novus Biologicals RHOB Lysates
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    ProSpec Recombinant Protein for RHOB
    Uscn Proteins for RHOB

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005625soluble fraction ----
    GO:0005634nucleus ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--


    RHOB for ontologies           About GeneDecksing



    RHOB Antibody Products: 
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    ThermoFisher Antibodies for RHOB

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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RHOB

    Protein Domains /
    Families
    for RHOB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RHOB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase

    Graphical View of Domain Structure for InterPro Entry P62745

    ProtoNet protein and cluster: P62745

    UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Function
    for RHOB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
    Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but
    affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as
    deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1
    to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for
    stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
    Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle
    cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells
    Induction: Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR)

    miRNA
    Products:            		miRTarBase miRNAs that target RHOB:
    hsa-let-7b (MIRT001599), hsa-mir-21 (MIRT003317), hsa-mir-223 (MIRT001109)

    OriGene 3'-UTR Clone: RHOB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOB
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOB (see all 31):
    hsa-miR-411* hsa-miR-30c hsa-miR-379* hsa-miR-4328 hsa-let-7a-2* hsa-miR-624* hsa-miR-30d hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RHOB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOB (see all 7)
    OriGene shRNA RFP: RHOB
    OriGene siRNA: RHOB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RHOB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RHOB (NM_004040)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOB 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOB

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS3888408
    GO:0005515protein binding IPI19637314
    GO:0005525GTP binding TAS1400319
    GO:0019003GDP binding IEA--


    RHOB for ontologies           About GeneDecksing


    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rhob):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  tumorigenesis 
     vision/eye 

    RHOB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RHOB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2Sema4D in semaphorin signaling
    		Sema4D in semaphorin signaling1.00
    		Semaphorin interactions0.44
    		Sema4D induced cell migration and growth-cone collapse0.83
    3Cell death signalling via NRAGE, NRIF and NADE
    		G alpha (12/13) signalling events0.39
    		Signaling by Rho GTPases0.25
    		Rho GTPase cycle0.25
    4Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    5Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RHOB
        G-protein signaling RhoB regulation pathway

    1 R&D Systems Pathway for RHOB
        Wnt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for RHOB
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RHOB
        G-protein signaling RhoB regulation pathway

    3 BioSystems Pathways for RHOB 
        Focal Adhesion
    Neural Crest Differentiation
    Androgen receptor signaling pathway

    5/14        Reactome Pathways for RHOB (see all 14)
        GPCR downstream signaling
    Hemostasis
    Signaling by Rho GTPases
    Developmental Biology
    G alpha (12/13) signalling events



    RHOB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/111 Interacting proteins for RHOB (P627451, 2, 3 ENSP000002722334) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFAIP1Q138291, 3, ENSP000002262254EBI-602647,EBI-2505861 I2D: score=2 STRING: ENSP00000226225
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    INSRP062132, 3, ENSP000003038304MINT-6800491 I2D: score=1 STRING: ENSP00000303830
    PTPN1P180312, 3, ENSP000003606834MINT-6800506 I2D: score=1 STRING: ENSP00000360683
    ARHGDIGQ998193, ENSP000002194094I2D: score=2 STRING: ENSP00000219409
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006184GTP catabolic process TAS3888408
    GO:0006915apoptotic process TAS19637314
    GO:0006927transformed cell apoptotic process ISS--
    GO:0007155cell adhesion ISS--


    RHOB for ontologies           About GeneDecksing



    Drugs & Compounds
    for RHOB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOB

    1 DrugBank Compound for RHOB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Botulinum Toxin Type ABoNT/A (see all 4)93384-43-1target--15140914

    10/18 Novoseek chemical compound relationships for RHOB gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azatyrosine 80.8 1 10667209 (1)
    geranylgeranyl pyrophosphate 56.4 7 12427032 (2), 12384510 (1), 19151402 (1)
    mevalonate 50.9 8 11788600 (2), 12384510 (2), 12427032 (2), 19151402 (1)
    lovastatin 43.1 10 19151402 (6), 12235235 (3), 10440923 (1)
    gtp 41.3 15 8939998 (3), 18377644 (3), 17198702 (1), 11918088 (1)
    gdp 34.9 6 8939998 (3)
    actinomycin d 21.6 3 16909123 (1), 11788600 (1), 19151402 (1)
    cycloheximide 13.2 1 19151402 (1)
    paclitaxel 8.18 2 16101130 (1), 11353846 (1)
    methionine 7.2 1 16170025 (1)

    Search CenterWatch for drugs/clinical trials and news about RHOB 

    Transcripts
    for RHOB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RHOB gene: 
    NM_004040.2  

    Unigene Cluster for RHOB:

    Ras homolog family member B
    Hs.502876  [show with all ESTs]
    Unigene Representative Sequence: NM_004040
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000272233(uc002rdv.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RHOB
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOB
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOB (see all 31):
    hsa-miR-411* hsa-miR-30c hsa-miR-379* hsa-miR-4328 hsa-let-7a-2* hsa-miR-624* hsa-miR-30d hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RHOB 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOB (see all 7)
    OriGene shRNA RFP: RHOB
    OriGene siRNA: RHOB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOB
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF171089.1 AF498971.1 AK124398.1 AK297495.1 AK309991.1 AK310813.1 AK312487.1 BC062781.1 
    BC066954.1 BT019546.1 BT019547.1 CR542272.1 M12174.1 X06820.1 

    20 DOTS entries:

    DT.92327084  DT.92339462  DT.92033160  DT.120991656  DT.120991663  DT.95377224  DT.220260  DT.91778836 
    DT.100798162  DT.91778826  DT.95376747  DT.100798160  DT.91778839  DT.100798158  DT.87018075  DT.91778835 
    DT.91852109  DT.95377285  DT.100798169  DT.40115663 

    24/864 AceView cDNA sequences (see all 864):

    BM976260 BM843334 Z41516 AI091225 CB054219 AI085583 AI261339 AI189876 
    AI672504 AI261378 AI285309 AA629787 AI685774 AI094301 AI654792 AF498971 
    BU848747 AI373063 AW103688 BG925159 AI871029 AI381677 AI391595 F25668 

    GeneLoc Exon Structure


    Expression
    for RHOB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACACAGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RHOB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RHOB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOB

    SOURCE GeneReport for Unigene cluster: Hs.502876
        SABiosciences Expression via Pathway-Focused PCR Arrays including RHOB: 
              Cancer Drug Targets in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOB

    Orthologs
    for RHOB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RHOB gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RHOB1 ras homolog gene family, member B 90.31(n)
    97.45(a)    		   395734  NM_204909.1  NP_990240.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RHOB6
    		 --
    		 93(a)
    		 1 ↔ 1
    		 1(155258630-155259223)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.75192 Transcribed sequence with moderate similarity to protein spP01121 (H.sapiens) RHOB_HUMAN TRANSFORMING PROTEIN RHOB (H6) less 87.57(n)    CF153261.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rhoaa1 ras homolog gene family, member Aa 72.66(n)
    86.24(a)    		   406411  NM_213137.1  NP_998302.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rho16
    		 Rho1
    		 82(a)
    		 1 → many
    		 2R(11990191-11994734)
    worm
    (Caenorhabditis elegans)    		 Secernentea rho-16
    		 Ras-like GTP-binding protein rhoA
    		 80(a)
    		 possible ortholog
    		 IV(16483178-16488988)


    ENSEMBL Gene Tree for RHOB (if available)
    TreeFam Gene Tree for RHOB (if available) 

    Paralogs
    for RHOB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOB gene
    RND12  RHOD2  RHOA2  RHOF2  RHOC2  RND32  
    18/56 SIMAP similar genes for RHOB using alignment to 1 protein entry:     RHOB_HUMAN(see all similar genes):
    RHOA    RHOC    ARHA    ARHE    RHOD    RND3
    RHOF    CDC42    RND2    ARHG    RHOG    RHOU
    RAC3    RHOV    RHOJ    RHOQ    RAC1    RAC2

    RHOB for paralogs           About GeneDecksing



    Genomic Variants
    for RHOB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/120 NCBI SNPs in RHOB are shown (see all 120)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1406329531,2
    		--20645076(+) TGCCAC/GGCATT 1 -- us2k10--------
    rs759070851,2
    		F,--20645109(+) AGATAA/GGACAG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1924783681,2
    		--20645279(+) TTTAGC/TACTCA 1 -- us2k10--------
    rs1499799501,2
    		--20645294(+) CCCCAC/GCATAT 1 -- us2k10--------
    rs1119213381,2
    		C,F,--20645456(+) TCACCG/TGTACT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1858445621,2
    		--20645482(+) ATCTAA/CAGGAT 1 -- us2k10--------
    rs26021601,2
    		C,F,A,H,--20645506(-) TGCACA/GCCAGG 1 -- us2k126Minor allele frequency- G:0.18NS EA NA WA CSA 2358
    rs1891046551,2
    		--20645653(+) GAACCC/GGGAAT 1 -- us2k10--------
    rs29243781,2
    		C,A,H,--20645666(-) TAGAAT/CGTACA 1 -- us2k111Minor allele frequency- C:0.19NA WA CSA EA 372
    rs124640171,2
    		H--20645733(+) TTGTAC/TATTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHOB (20646835 - 20649201 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RHOB: --
    Human Gene Mutation Database (HGMD): RHOB

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    Disorders / Diseases
    for RHOB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RHOB for disorders           About GeneDecksing

    OMIM gene information: 165370    OMIM disorders: --

    20/34 diseases for RHOB (see all 34):    About MalaCards
    sertoli cell-only syndrome    traumatic brain injury    clear cell renal cell carcinoma    brain injury
    renal cell carcinoma    myotonic dystrophy    pancreatic ductal adenocarcinoma    tangier disease
    cerebral infarction    ovarian cancer    stomatitis    fibrosarcoma
    spasticity    carcinoma    thyroiditis    adenocarcinoma
    thyroid carcinoma    ovarian carcinoma    cerebritis    osteoarthritis

    10 Novoseek disease relationships for RHOB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 30.6 29 15102679 (4), 18340357 (3), 11918088 (3), 19602596 (2) (see all 16)
    cancer 25.8 12 15102679 (2), 14647415 (2), 16909123 (2), 19637314 (1) (see all 7)
    cancer lung 21.3 21 15102679 (5), 18047684 (4), 19602596 (2), 11641777 (1) (see all 6)
    neoplastic transformation 19.4 1 12706111 (1)
    nsclc 14.9 13 17096327 (6)
    ovarian cancer 11.4 5 16796923 (3), 18340357 (2)
    metastasis 8.27 2 12939257 (1), 16909123 (1)
    adenocarcinoma 4.08 4 17096327 (2), 15102679 (1)
    necrosis 0 1 11062238 (1)
    carcinoma 0 1 15102679 (1)

    Human Genome Epidemiology (HuGE) Navigator: RHOB (4 documents)

    Export disorders for RHOB gene to outside databases

    Publications
    for RHOB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOB gene, integrated from 9 sources (see all 189):
    (articles sorted by number of sources associating them with RHOB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Coding sequence of human rho cDNAs clone 6 and clone 9. (PubMed id 3283705)1, 2, 3 Chardin P.... Tavitian A. (1988)
    2. RhoB protects human keratinocytes from UVB-induced ap optosis through epidermal growth factor receptor signaling. (PubMed id 16278215)1, 3, 9 Canguilhem B....Favre G. (2005)
    3. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096)1, 2, 9 Arthur W.T.... Wennerberg K. (2002)
    4. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. (PubMed id 7713879)1, 2, 9 Armstrong S.A.... Brown M.S. (1995)
    5. PRK1 is targeted to endosomes by the small GTPase, RhoB. (PubMed id 9478917)1, 2, 9 Mellor H.... Parker P.J. (1998)
    6. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. (PubMed id 21373644)1, 2 Srougi M.C. and Burridge K. (2011)
    7. Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)1, 2 Kamijo K....Miki T. (2006)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase. (PubMed id 15226397)1, 2 Wherlock M.... Mellor H. (2004)

    External Searches for RHOB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RHOB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388 HGNC: 668 AceView: RHOB Ensembl:ENSG00000143878 euGenes: HUgn388
    ECgene: RHOB H-InvDB: RHOB

    Other Databases showing RHOB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RHOB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOB Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RHOB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RHOB gene:
    Search GeneIP for patents involving RHOB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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