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Aliases for RHOB Gene

Aliases for RHOB Gene

  • Ras Homolog Family Member B 2 3 5
  • Ras Homolog Gene Family, Member B 2 3
  • Rho CDNA Clone 6 3 4
  • Oncogene RHO H6 2 3
  • ARH6 3 4
  • ARHB 3 4
  • H6 3 4
  • Rho-Related GTP-Binding Protein RhoB 3
  • Aplysia RAS-Related Homolog 6 3
  • MSTP081 3
  • MST081 3
  • RHOH6 3

External Ids for RHOB Gene

Previous HGNC Symbols for RHOB Gene

  • ARH6
  • ARHB

Previous GeneCards Identifiers for RHOB Gene

  • GC02P020632
  • GC02P020568
  • GC02P020510
  • GC02P020404
  • GC02P020646

Summaries for RHOB Gene

GeneCards Summary for RHOB Gene

RHOB (Ras Homolog Family Member B) is a Protein Coding gene. Diseases associated with RHOB include Sertoli Cell-Only Syndrome. Among its related pathways are p75 NTR receptor-mediated signalling and Semaphorin interactions. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RHOC.

UniProtKB/Swiss-Prot for RHOB Gene

  • Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Gene Wiki entry for RHOB Gene

Additional gene information for RHOB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOB Gene

Genomics for RHOB Gene

Regulatory Elements for RHOB Gene

Enhancers for RHOB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H020566 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 20.9 +127.0 127037 14 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 PUM2 TTC32 RHOB GDF7 ENSG00000228950 WDR35 RNU6-961P HS1BP3-IT1 HS1BP3 ENSG00000269976
GH02H020592 2 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +149.5 149493 8 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF766 RHOB GDF7 ENSG00000228950 APOB HS1BP3 HS1BP3-IT1 RPS25P3
GH02H020421 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -23.2 -23230 4 FOXA2 YY1 ZNF766 ELK1 FOS RUNX3 NCOA1 REST ZNF184 ETV4 RHOB ENSG00000228950 HS1BP3 GC02P020419 LOC105373465
GH02H020505 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +59.7 59660 1 ELF3 PKNOX1 ATF1 ARID4B DMAP1 BATF ZSCAN9 RAD21 RARA ATF7 ENSG00000228950 RHOB ENSG00000269976 HS1BP3 ENSG00000227047 ENSG00000279307
GH02H020633 1.5 Ensembl ENCODE dbSUPER 11.6 +188.6 188574 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A YY1 ELK1 ZNF143 SP5 MXD4 ENSG00000228950 RHOB GDF7 PUM2 HS1BP3 GC02M020612
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOB on UCSC Golden Path with GeneCards custom track

Promoters for RHOB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000113804 929 3601 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for RHOB Gene

Chromosome:
2
Start:
20,447,071 bp from pter
End:
20,449,445 bp from pter
Size:
2,375 bases
Orientation:
Plus strand

Genomic View for RHOB Gene

Genes around RHOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOB Gene

Proteins for RHOB Gene

  • Protein details for RHOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62745-RHOB_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoB
    Protein Accession:
    P62745
    Secondary Accessions:
    • B2R692
    • P01121
    • Q5U0H6
    • Q7RTN5
    • Q7RTR9
    • Q9CUV7

    Protein attributes for RHOB Gene

    Size:
    196 amino acids
    Molecular mass:
    22123 Da
    Quaternary structure:
    • Binds ROCK1 and ROCK2 (By similarity). Also binds PKN1/PRK1 (PubMed:9478917). Interacts with ARGGEF3 (PubMed:12221096). Interacts with RTKN (By similarity). Interacts with AKAP13 (PubMed:11546812). Interacts with RIPOR1 (PubMed:27807006).
    Miscellaneous:
    • RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.

    Three dimensional structures from OCA and Proteopedia for RHOB Gene

neXtProt entry for RHOB Gene

Post-translational modifications for RHOB Gene

  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOB Gene

Domains & Families for RHOB Gene

Gene Families for RHOB Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RHOB Gene

Suggested Antigen Peptide Sequences for RHOB Gene

Graphical View of Domain Structure for InterPro Entry

P62745

UniProtKB/Swiss-Prot:

RHOB_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOB: view

Function for RHOB Gene

Molecular function for RHOB Gene

UniProtKB/Swiss-Prot Function:
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).

Phenotypes From GWAS Catalog for RHOB Gene

Gene Ontology (GO) - Molecular Function for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 3888408
GO:0005515 protein binding IPI 19637314
GO:0005525 GTP binding TAS 1400319
GO:0019003 GDP binding IEA --
genes like me logo Genes that share ontologies with RHOB: view
genes like me logo Genes that share phenotypes with RHOB: view

Animal Models for RHOB Gene

MGI Knock Outs for RHOB:

Animal Model Products

CRISPR Products

miRNA for RHOB Gene

miRTarBase miRNAs that target RHOB

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOB
  • Applied Biological Materials Clones for RHOB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOB Gene

Localization for RHOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOB Gene

Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOB gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
endosome 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus ISS --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005770 late endosome IEA --
genes like me logo Genes that share ontologies with RHOB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOB Gene

Pathways & Interactions for RHOB Gene

genes like me logo Genes that share pathways with RHOB: view

SIGNOR curated interactions for RHOB Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 16236794
GO:0000910 cytokinesis IMP --
GO:0001525 angiogenesis IEA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
genes like me logo Genes that share ontologies with RHOB: view

Drugs & Compounds for RHOB Gene

(9) Drugs for RHOB Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Botulinum Toxin Type A Approved, Investigational Pharma Target 0

(10) Additional Compounds for RHOB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOB: view

Transcripts for RHOB Gene

mRNA/cDNA for RHOB Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(864) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOB Gene

Ras homolog family member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOB
  • Applied Biological Materials Clones for RHOB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RHOB Gene

No ASD Table

Relevant External Links for RHOB Gene

GeneLoc Exon Structure for
RHOB
ECgene alternative splicing isoforms for
RHOB

Expression for RHOB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOB Gene

This gene is overexpressed in Artery - Tibial (x4.6).

Protein differential expression in normal tissues from HIPED for RHOB Gene

This gene is overexpressed in Frontal cortex (21.9), Brain (19.9), and Fetal Brain (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RHOB Gene



NURSA nuclear receptor signaling pathways regulating expression of RHOB Gene:

RHOB

SOURCE GeneReport for Unigene cluster for RHOB Gene:

Hs.502876

Evidence on tissue expression from TISSUES for RHOB Gene

  • Nervous system(4.9)
  • Kidney(4.8)
  • Lung(3.6)
  • Intestine(3.5)
  • Liver(3.3)
  • Muscle(3.1)
  • Heart(3)
  • Pancreas(3)
  • Stomach(2.6)
  • Adrenal gland(2.4)
  • Blood(2.4)
  • Eye(2.3)
  • Skin(2.2)
  • Spleen(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with RHOB: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOB Gene

Orthologs for RHOB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOB 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia RHOB 33 34
  • 96.77 (n)
cow
(Bos Taurus)
Mammalia RHOB 33 34
  • 96.6 (n)
rat
(Rattus norvegicus)
Mammalia Rhob 33
  • 95.07 (n)
mouse
(Mus musculus)
Mammalia Rhob 33 16 34
  • 94.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RHOB 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CRHOB 34
  • 97 (a)
OneToOne
RHOB 33
  • 90.31 (n)
lizard
(Anolis carolinensis)
Reptilia RHOB 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhob 33
  • 84.69 (n)
Str.7519 33
zebrafish
(Danio rerio)
Actinopterygii rhoac 34
  • 84 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rho1 34
  • 82 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rho-1 34
  • 80 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 34
  • 60 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11308 34
  • 79 (a)
OneToMany
Species where no ortholog for RHOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOB Gene

ENSEMBL:
Gene Tree for RHOB (if available)
TreeFam:
Gene Tree for RHOB (if available)

Paralogs for RHOB Gene

Variants for RHOB Gene

Sequence variations from dbSNP and Humsavar for RHOB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000033993 -- 20,448,668(+) GACCA(A/T)CTTTC utr-variant-3-prime
rs1000450848 -- 20,446,585(+) TGGGG(G/T)GTGTG upstream-variant-2KB
rs1000590807 -- 20,446,653(+) CTGCC(C/T)CTCCC upstream-variant-2KB
rs1000634916 -- 20,449,701(+) TACTC(A/G)GTTCA downstream-variant-500B
rs1000744875 -- 20,445,591(+) TCAGG(C/T)TGTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RHOB Gene

Variant ID Type Subtype PubMed ID
dgv56n68 CNV loss 17160897
esv29979 CNV loss 17803354
nsv455830 CNV loss 19166990
nsv482049 CNV gain 20164927
nsv581166 CNV loss 21841781

Variation tolerance for RHOB Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOB Gene

Human Gene Mutation Database (HGMD)
RHOB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOB Gene

Disorders for RHOB Gene

MalaCards: The human disease database

(1) MalaCards diseases for RHOB Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sertoli cell-only syndrome
  • del castillo syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RHOB in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHOB

Genetic Association Database (GAD)
RHOB
Human Genome Epidemiology (HuGE) Navigator
RHOB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOB
genes like me logo Genes that share disorders with RHOB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOB Gene

Publications for RHOB Gene

  1. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. (PMID: 16278215) Canguilhem B … Favre G (The Journal of biological chemistry 2005) 2 3 22 60
  2. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur WT … Wennerberg K (The Journal of biological chemistry 2002) 3 4 22 60
  3. PRK1 is targeted to endosomes by the small GTPase, RhoB. (PMID: 9478917) Mellor H … Parker PJ (The Journal of biological chemistry 1998) 3 4 22 60
  4. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. (PMID: 7713879) Armstrong SA … Brown MS (The Journal of biological chemistry 1995) 3 4 22 60
  5. Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P … Tavitian A (Nucleic acids research 1988) 2 3 4 60

Products for RHOB Gene

  • Addgene plasmids for RHOB

Sources for RHOB Gene

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