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RHOB Gene

protein-coding   GIFtS: 63
GCID: GC02P020646

Ras Homolog Family Member B

(Previous names: ras homolog gene family, member B)
(Previous symbols: ARH6, ARHB)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member B1 2     h62 3
ARH61 2 3 5     RHOH62 5
ARHB1 2 3 5     MST0812
Ras Homolog Gene Family, Member B1 2     MSTP0812
Oncogene RHO H61 2     Aplysia RAS-Related Homolog 62
Rho CDNA Clone 62 3     Rho-Related GTP-Binding Protein RhoB2

External Ids:    HGNC: 6681   Entrez Gene: 3882   Ensembl: ENSG000001438787   OMIM: 1653705   UniProtKB: P627453   

Export aliases for RHOB gene to outside databases

Previous GC identifers: GC02P020632 GC02P020568 GC02P020510 GC02P020404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHOB Gene:
RHOB (ras homolog family member B) is a protein-coding gene. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RND1.

UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development
but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in
tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of
proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to
lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell
survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin
contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in
breast cancer cells

Gene Wiki entry for RHOB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOB gene promoter:
         CREB   GR   AP-1   deltaCREB   ATF-2   AP-2beta   GR-alpha   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RHOB promoter sequence
   Search Chromatin IP Primers for RHOB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24

RHOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P020646:  view genomic region     (about GC identifiers)

Start:
20,646,835 bp from pter      End:
20,649,201 bp from pter
Size:
2,367 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoB precursor  
Size: 196 amino acids; 22123 Da
Subunit: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13
Miscellaneous: RHOB is one of the targets of farnesyltransferase inhibitors which are currently under
investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause
mislocalization, leading to apoptosis and antineoplastic effects
1 PDB 3D structure from and Proteopedia for RHOB:
2FV8 (3D)    
Secondary accessions: B2R692 P01121 Q5U0H6 Q7RTN5 Q7RTR9 Q9CUV7

Explore the universe of human proteins at neXtProt for RHOB: NX_P62745

Explore proteomics data for RHOB at MOPED

Post-translational modifications: 

  • Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane
    while the geranylgeranylated form is localized to the endosome1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RHOB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004031.1  
    ENSEMBL proteins: 
     ENSP00000272233  
    Reactome Protein details: P62745

    RHOB Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for RHOB
    Cloud-Clone Corp. Proteins for RHOB

     
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    antibodies-online proteins for RHOB (10 products) 

     
    antibodies-online peptides for RHOB

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    RHOB Assay Products:

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    Cloud-Clone Corp. ELISAs for RHOB
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    antibodies-online kits for RHOB (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P62745

    ProtoNet protein and cluster: P62745

    UniProtKB/Swiss-Prot: RHOB_HUMAN, P62745
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RHOB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOB_HUMAN, P62745
    Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development
    but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in
    tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of
    proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to
    lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell
    survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin
    contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in
    breast cancer cells
    Induction: Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS3888408
    GO:0005515protein binding IPI19637314
    GO:0005525GTP binding TAS1400319
    GO:0019003GDP binding IEA--
         
    Find genes that share ontologies with RHOB           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhob):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  tumorigenesis 
     vision/eye 

    Find genes that share phenotypes with RHOB           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RHOB

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOB:
    hsa-mir-30a-5p (MIRT028477), hsa-mir-335-5p (MIRT016875), hsa-mir-421 (MIRT039419), hsa-let-7b-5p (MIRT001599), hsa-mir-21-5p (MIRT003317), hsa-mir-223-3p (MIRT001109)

    Block miRNA regulation of human, mouse, rat RHOB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOB (see all 31):
    hsa-miR-411* hsa-miR-30c hsa-miR-379* hsa-miR-4328 hsa-let-7a-2* hsa-miR-624* hsa-miR-30d hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidRHOB 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RHOB
    Predesigned siRNA for gene silencing in human, mouse, rat RHOB

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RHOB (NM_004040)
    Sino Biological Human cDNA Clone for RHOB
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOB

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOB

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13328) for RHOB 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOB_HUMAN, P62745: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow.
    Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the
    nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a
    ECT2-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus5
    plasma membrane5
    cytosol4
    cytoskeleton2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IDA15226397

    Find genes that share ontologies with RHOB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOB About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90
    3L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    4Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    5Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43


    Find genes that share SuperPaths with RHOB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RHOB
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RHOB (see all 33)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for RHOB
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RHOB
        G-protein signaling RhoB regulation pathway

    4 BioSystems Pathways for RHOB
        Focal Adhesion
    Spinal Cord Injury
    Neural Crest Differentiation
    Androgen receptor signaling pathway


    4 Reactome Pathways for RHOB
        Sema4D induced cell migration and growth-cone collapse
    G alpha (12/13) signalling events
    Rho GTPase cycle
    GPVI-mediated activation cascade


        Pathway & Disease-focused RT2 Profiler PCR Arrays including RHOB: 
              Cancer Drug Targets in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RHOB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOB (P627451, 2, 3 ENSP000002722334) via UniProtKB, MINT, STRING, and/or I2D (see all 179)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFAIP1Q138291, 3, ENSP000002262254EBI-602647,EBI-2505861 I2D: score=2 STRING: ENSP00000226225
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    INSRP062132, 3, ENSP000003038304MINT-6800491 I2D: score=1 STRING: ENSP00000303830
    PTPN1P180312, 3, ENSP000003606834MINT-6800506 I2D: score=1 STRING: ENSP00000360683
    ARHGDIGQ998193, ENSP000002194094I2D: score=2 STRING: ENSP00000219409
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP16236794
    GO:0001525angiogenesis IEA--
    GO:0006184GTP catabolic process TAS3888408
    GO:0006915apoptotic process TAS19637314
    GO:0006927transformed cell apoptotic process ISS--

    Find genes that share ontologies with RHOB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOB

    1 DrugBank Compound for RHOB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Botulinum Toxin Type ABoNT/A (see all 4)93384-43-1target--15140914

    Selected Novoseek inferred chemical compound relationships for RHOB gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azatyrosine 80.8 1 10667209 (1)
    geranylgeranyl pyrophosphate 56.4 7 12427032 (2), 12384510 (1), 19151402 (1)
    mevalonate 50.9 8 11788600 (2), 12384510 (2), 12427032 (2), 19151402 (1)
    lovastatin 43.1 10 19151402 (6), 12235235 (3), 10440923 (1)
    gtp 41.3 15 8939998 (3), 18377644 (3), 17198702 (1), 11918088 (1)
    gdp 34.9 6 8939998 (3)
    actinomycin d 21.6 3 16909123 (1), 11788600 (1), 19151402 (1)
    cycloheximide 13.2 1 19151402 (1)
    paclitaxel 8.18 2 16101130 (1), 11353846 (1)
    methionine 7.2 1 16170025 (1)



    Find genes that share compounds with RHOB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHOB gene: 
    NM_004040.2  

    Unigene Cluster for RHOB:

    Ras homolog family member B
    Hs.502876  [show with all ESTs]
    Unigene Representative Sequence: NM_004040
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000272233(uc002rdv.3)
    miRNA
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    hsa-miR-411* hsa-miR-30c hsa-miR-379* hsa-miR-4328 hsa-let-7a-2* hsa-miR-624* hsa-miR-30d hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidRHOB 3' UTR sequence
    Inhib. RNA
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    Flow Cytometry
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    Additional mRNA sequence: 

    AF171089.1 AF498971.1 AK124398.1 AK297495.1 AK309991.1 AK310813.1 AK312487.1 BC062781.1 
    BC066954.1 BT019546.1 BT019547.1 CR542272.1 M12174.1 X06820.1 

    20 DOTS entries:

    DT.92327084  DT.92339462  DT.92033160  DT.120991656  DT.120991663  DT.95377224  DT.220260  DT.91778836 
    DT.100798162  DT.91778826  DT.95376747  DT.100798160  DT.91778839  DT.100798158  DT.87018075  DT.91778835 
    DT.91852109  DT.95377285  DT.100798169  DT.40115663 

    Selected AceView cDNA sequences (see all 864):

    AI361343 NM_004040 AW052113 AI419186 AI082782 AI366717 AI433662 AI590305 
    R35210 AI350911 AI377430 AI871029 CR626079 AA348855 Z41516 AI220416 
    AI640591 AI784482 CB177954 CR542272 BQ025501 BP379827 BE857606 BM708456 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACAGTTT
    RHOB Expression
    About this image


    RHOB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    RHOB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502876
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RHOB: 
              Cancer Drug Targets in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RHOB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhob1 , 5 ras homolog gene family, member B1, 5 94.9(n)1
    100(a)1
      12 (3.88 cM)5
    118521  NM_007483.21  NP_031509.11 
     84977635 
    chicken
    (Gallus gallus)
    Aves RHOB1 ras homolog family member B 90.31(n)
    97.45(a)
      395734  NM_204909.1  NP_990240.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOB6
    ras homolog family member B
    93(a)
    1 ↔ 1
    1(155258630-155259223)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.75192 Transcribed sequence with moderate similarity to protein more 87.57(n)    CF153261.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rhoac6
    ras homolog gene family, member Ac
    84(a)
    many ↔ many
    23(811061-821065) ENSDARG00000015429
    fruit fly
    (Drosophila melanogaster)
    Insecta Rho16
    Rho1
    82(a)
    1 → many
    2R(11990191-11994734)
    worm
    (Caenorhabditis elegans)
    Secernentea rho-16
    Protein RHO-1 (rho-1) mRNA, complete cds
    80(a)
    1 → many
    IV(16482851-16489021) WBGene00004357
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHO16
    GTP-binding protein of the rho subfamily of Ras-li...
    60(a)
    1 → many
    XVI(875368-875997) YPR165W


    ENSEMBL Gene Tree for RHOB (if available)
    TreeFam Gene Tree for RHOB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOB gene
    RND12  RHOA2  RHOD2  RHOF2  ENSG000002718102  RHOC2  RND32  RND22  
    Selected SIMAP similar genes for RHOB using alignment to 1 protein entry:     RHOB_HUMAN(see all similar genes):
    RHOA    RHOC    ARHA    ARHE    RHOD    RND3
    RHOF    CDC42    RND2    ARHG    RHOG    RHOU
    RAC3    RHOV    RHOJ    RHOQ    RAC1    RAC2

    Find genes that share paralogs with RHOB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOB (see all 140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406329531,2
    C--20645076(+) TGCCAC/GGCATT 1 -- us2k10--------
    rs759070851,2
    C,F--20645109(+) AGATAA/GGACAG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1924783681,2
    --20645279(+) TTTAGC/TACTCA 1 -- us2k10--------
    rs1499799501,2
    C--20645294(+) CCCCAC/GCATAT 1 -- us2k10--------
    rs1119213381,2
    C,F--20645456(+) TCACCG/TGTACT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1858445621,2
    --20645482(+) ATCTAA/CAGGAT 1 -- us2k10--------
    rs26021601,2
    C,F,A,H--20645506(-) TGCACA/GCCAGG 1 -- us2k126Minor allele frequency- G:0.18NS EA NA WA CSA 2358
    rs1891046551,2
    --20645653(+) GAACCC/GGGAAT 1 -- us2k10--------
    rs29243781,2
    C,A,H--20645666(-) TAGAAT/CGTACA 1 -- us2k111Minor allele frequency- C:0.19NA WA CSA EA 372
    rs124640171,2
    H--20645733(+) TTGTAC/TATTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHOB (20646835 - 20649201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RHOB:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv56n68CNV Loss17160897
    esv29979CNV Loss17803354
    nsv455830CNV Loss19166990
    nsv482049CNV Gain20164927
    dgv4068n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): RHOB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOB
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165370    OMIM disorders: --


    Find genes that share disorders with RHOB           About GenesLikeMe

    10 Novoseek inferred disease relationships for RHOB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 30.6 29 15102679 (4), 18340357 (3), 11918088 (3), 19602596 (2) (see all 16)
    cancer 25.8 12 15102679 (2), 14647415 (2), 16909123 (2), 19637314 (1) (see all 7)
    cancer lung 21.3 21 15102679 (5), 18047684 (4), 19602596 (2), 11641777 (1) (see all 6)
    neoplastic transformation 19.4 1 12706111 (1)
    nsclc 14.9 13 17096327 (6)
    ovarian cancer 11.4 5 16796923 (3), 18340357 (2)
    metastasis 8.27 2 12939257 (1), 16909123 (1)
    adenocarcinoma 4.08 4 17096327 (2), 15102679 (1)
    necrosis 0 1 11062238 (1)
    carcinoma 0 1 15102679 (1)

    Genetic Association Database (GAD): RHOB
    Human Genome Epidemiology (HuGE) Navigator: RHOB (4 documents)

    Export disorders for RHOB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOB gene, integrated from 10 sources (see all 200):
    (articles sorted by number of sources associating them with RHOB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coding sequence of human rho cDNAs clone 6 and clone 9. (PubMed id 3283705)1, 2, 3 Chardin P.... Tavitian A. (Nucleic Acids Res. 1988)
    2. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. (PubMed id 16278215)1, 3, 9 Canguilhem B....Favre G. (J. Biol. Chem. 2005)
    3. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096)1, 2, 9 Arthur W.T.... Wennerberg K. (J. Biol. Chem. 2002)
    4. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. (PubMed id 7713879)1, 2, 9 Armstrong S.A.... Brown M.S. (J. Biol. Chem. 1995)
    5. PRK1 is targeted to endosomes by the small GTPase, RhoB. (PubMed id 9478917)1, 2, 9 Mellor H.... Parker P.J. (J. Biol. Chem. 1998)
    6. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. (PubMed id 21373644)1, 2 Srougi M.C. and Burridge K. (PLoS ONE 2011)
    7. Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. (PubMed id 21750679)1, 4 Allanore Y....Martinez M. (PLoS Genet. 2011)
    8. Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. (PubMed id 20237151)1, 4 Zintzaras E....Karachalios T. (Am. J. Epidemiol. 2010)
    9. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    10. Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis. (PubMed id 18471322)1, 4 Shi D....Jiang Q. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388 HGNC: 668 AceView: RHOB Ensembl:ENSG00000143878 euGenes: HUgn388
    ECgene: RHOB H-InvDB: RHOB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHOB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHOB gene:
    Search GeneIP for patents involving RHOB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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