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Aliases for RHOA Gene

Aliases for RHOA Gene

  • Ras Homolog Family Member A 2 3 5
  • ARH12 3 4
  • RHO12 3 4
  • ARHA 3 4
  • Ras Homolog Gene Family, Member A 2
  • Aplysia Ras-Related Homolog 12 3
  • Small GTP Binding Protein RhoA 3
  • Transforming Protein RhoA 3
  • Rho CDNA Clone 12 4
  • Oncogene RHO H12 3
  • RHOH12 3
  • H12 4

External Ids for RHOA Gene

Previous HGNC Symbols for RHOA Gene

  • ARH12
  • ARHA

Previous GeneCards Identifiers for RHOA Gene

  • GC03M049357
  • GC03M049371

Summaries for RHOA Gene

Entrez Gene Summary for RHOA Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

CIViC summary for RHOA Gene

GeneCards Summary for RHOA Gene

RHOA (Ras Homolog Family Member A) is a Protein Coding gene. Diseases associated with RHOA include Colorectal Cancer and Pulmonary Hypertension. Among its related pathways are p75 NTR receptor-mediated signalling and E-cadherin signaling in keratinocytes. GO annotations related to this gene include GTP binding and myosin binding. An important paralog of this gene is RHOC.

UniProtKB/Swiss-Prot for RHOA Gene

  • Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695).

  • (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.

Gene Wiki entry for RHOA Gene

Additional gene information for RHOA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOA Gene

Genomics for RHOA Gene

Regulatory Elements for RHOA Gene

Enhancers for RHOA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H049338 1.9 FANTOM5 ENCODE dbSUPER 16.7 +66.9 66949 14 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 AMT QRICH1 ATRIP ENSG00000235236 WDR6 RBM6 BSN-AS1 DALRD3 RBM5 IP6K2
GH03H049265 0.8 Ensembl ENCODE 10.5 +146.7 146668 2 PRDM12 ZFP64 ZC3H11A ZNF781 ZNF518A ZNF697 WDR6 NICN1 CCDC36 C3orf84 CCDC71 KLHDC8B ENSG00000223343 LAMB2 RHOA TCTA
GH03H049237 1.7 FANTOM5 Ensembl ENCODE 3.3 +173.8 173798 2 PKNOX1 FOXA2 ARNT DMAP1 ZNF766 CBX5 NFYC ZNF592 KAT8 MEF2D WDR6 AMT IP6K2 TREX1 ZNF589 USP4 APEH DALRD3 ENSG00000235236 RHOA
GH03H049248 1.4 FANTOM5 Ensembl ENCODE 3.6 +164.1 164069 1 ATF1 JUN MAX CEBPG EGR1 ATF7 CREM HLF CEBPB ATF2 AMT WDR6 USP4 C3orf62 LAMB2 KLHDC8B CCDC71 DALRD3 RHOA ARIH2
GH03H049269 0.4 ENCODE 10.5 +142.3 142342 3 ATF2 ZIC2 AMT WDR6 CCDC36 C3orf84 KLHDC8B CCDC71 DAG1 RNA5SP130 LAMB2 RHOA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOA on UCSC Golden Path with GeneCards custom track

Promoters for RHOA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152220 1298 2601 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for RHOA Gene

Chromosome:
3
Start:
49,359,136 bp from pter
End:
49,412,998 bp from pter
Size:
53,863 bases
Orientation:
Minus strand

Genomic View for RHOA Gene

Genes around RHOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOA Gene

Proteins for RHOA Gene

  • Protein details for RHOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61586-RHOA_HUMAN
    Recommended name:
    Transforming protein RhoA
    Protein Accession:
    P61586
    Secondary Accessions:
    • P06749
    • Q53HM4
    • Q5U024
    • Q9UDJ0
    • Q9UEJ4

    Protein attributes for RHOA Gene

    Size:
    193 amino acids
    Molecular mass:
    21768 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with ARHGEF28 (By similarity). Interacts (via GTP-bound form) with RIPOR1 (via N-terminus); this interaction links RHOA to STK24 and STK26 kinases (PubMed:27807006). Interacts with RIPOR2 (via active GTP- or inactive GDP-bound forms) isoform 1 and isoform 2; these interactions are direct, block the loading of GTP to RHOA and decrease upon chemokine CCL19 stimulation in primary T lymphocytes (PubMed:25588844). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with DIAPH1 (PubMed:23325789). Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation. Interacts with RACK1; enhances RHOA activation. Interacts with PKP4; the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with ARHGDIA; this interaction inactivates and stabilizes RHOA. Interacts with ARHGDIB. Interacts (GTP-bound form) with KCNA2 (via cytoplasmic N-terminal domain) (PubMed:9635436).

    Three dimensional structures from OCA and Proteopedia for RHOA Gene

neXtProt entry for RHOA Gene

Post-translational modifications for RHOA Gene

  • (Microbial infection) AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
  • (Microbial infection) Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.
  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • (Microbial infection) Substrate for botulinum ADP-ribosyltransferase.
  • Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling (PubMed:11162591). Phosphorylation by SLK at Ser-188 in response to AGTR2 activation (By similarity).
  • Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
  • Ubiquitination at Lys135
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RHOA (RHOA)

No data available for DME Specific Peptides for RHOA Gene

Domains & Families for RHOA Gene

Gene Families for RHOA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RHOA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61586

UniProtKB/Swiss-Prot:

RHOA_HUMAN :
  • The basic-rich region is essential for yopT recognition and cleavage.
  • Belongs to the small GTPase superfamily. Rho family.
Domain:
  • The basic-rich region is essential for yopT recognition and cleavage.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOA: view

Function for RHOA Gene

Molecular function for RHOA Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GTP hydrolysis is stimulated by ARHGAP30.
UniProtKB/Swiss-Prot Function:
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.

Phenotypes From GWAS Catalog for RHOA Gene

Gene Ontology (GO) - Molecular Function for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,TAS 10436159
GO:0005515 protein binding IPI 9214622
GO:0005525 GTP binding IEA,IDA 12777804
GO:0017022 myosin binding IPI 15644318
genes like me logo Genes that share ontologies with RHOA: view
genes like me logo Genes that share phenotypes with RHOA: view

Animal Model Products

CRISPR Products

miRNA for RHOA Gene

miRTarBase miRNAs that target RHOA

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOA
  • Applied Biological Materials Clones for RHOA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOA Gene

Localization for RHOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOA Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Cell projection, lamellipodium. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOA gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
endoplasmic reticulum 5
cytosol 5
nucleus 4
endosome 4
mitochondrion 3
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IMP 19887681
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RHOA: view

Pathways & Interactions for RHOA Gene

genes like me logo Genes that share pathways with RHOA: view

Pathways by source for RHOA Gene

SIGNOR curated interactions for RHOA Gene

Gene Ontology (GO) - Biological Process for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction TAS 10436159
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with RHOA: view

Drugs & Compounds for RHOA Gene

(68) Drugs for RHOA Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 528
Pravastatin Approved Pharma Competitive, Inhibitor 153
atorvastatin Approved Pharma Competitive, Inhibitor 0
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(43) Additional Compounds for RHOA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for RHOA Gene

Compound Action Cas Number
CCG-1423 RhoA inhibitor 285986-88-1
genes like me logo Genes that share compounds with RHOA: view

Drug Products

Transcripts for RHOA Gene

Unigene Clusters for RHOA Gene

Ras homolog family member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOA
  • Applied Biological Materials Clones for RHOA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RHOA Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: - - -
SP4: - - -

Relevant External Links for RHOA Gene

GeneLoc Exon Structure for
RHOA
ECgene alternative splicing isoforms for
RHOA

Expression for RHOA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOA Gene

mRNA differential expression in normal tissues according to GTEx for RHOA Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for RHOA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RHOA Gene



Protein tissue co-expression partners for RHOA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOA Gene:

RHOA

SOURCE GeneReport for Unigene cluster for RHOA Gene:

Hs.247077

Evidence on tissue expression from TISSUES for RHOA Gene

  • Nervous system(5)
  • Blood(4.9)
  • Eye(4.9)
  • Intestine(4.9)
  • Lung(4.8)
  • Skin(4.8)
  • Kidney(4.4)
  • Liver(4.2)
  • Bone(4)
  • Pancreas(3.9)
  • Muscle(3.8)
  • Heart(3.7)
  • Stomach(3.5)
  • Adrenal gland(3.1)
  • Lymph node(3.1)
  • Bone marrow(3)
  • Spleen(2.9)
  • Thyroid gland(2.3)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with RHOA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOA Gene

Orthologs for RHOA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOA 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia RHOA 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOA 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOA 33 34
  • 95.34 (n)
rat
(Rattus norvegicus)
Mammalia Rhoa 33
  • 94.13 (n)
cow
(Bos Taurus)
Mammalia RHOA 33 34
  • 93.96 (n)
mouse
(Mus musculus)
Mammalia Rhoa 33 16
  • 93.78 (n)
4930544G11Rik 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRHOA 34
  • 99 (a)
OneToMany
RHOA 33
  • 83.77 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 99 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoa.2 33
  • 77.2 (n)
Str.942 33
zebrafish
(Danio rerio)
Actinopterygii rhoaa 34
  • 93 (a)
ManyToMany
rhoab 33
  • 74.96 (n)
wufc17g01 33
fruit fly
(Drosophila melanogaster)
Insecta Rho1 34
  • 87 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rho-1 34
  • 88 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 33 34
  • 63.7 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10626g 33
  • 63.39 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR183W 33
  • 62.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11308 34
  • 86 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01484 33
  • 64.2 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rho1 33
  • 63.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5323 33
Species where no ortholog for RHOA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOA Gene

ENSEMBL:
Gene Tree for RHOA (if available)
TreeFam:
Gene Tree for RHOA (if available)

Paralogs for RHOA Gene

Paralogs for RHOA Gene

Pseudogenes.org Pseudogenes for RHOA Gene

genes like me logo Genes that share paralogs with RHOA: view

Variants for RHOA Gene

Sequence variations from dbSNP and Humsavar for RHOA Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000024406 -- 49,396,419(+) AATAC(-/A)AAAAA intron-variant
rs1000124313 -- 49,365,109(+) GAGGG(A/G)AGCCT intron-variant
rs1000143378 -- 49,393,539(+) GCGAT(C/G)TACCT intron-variant
rs1000151172 -- 49,378,012(+) GGTGT(A/G)GTGGT intron-variant
rs1000155692 -- 49,364,863(+) GCTAC(C/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOA Gene

Variant ID Type Subtype PubMed ID
esv3596125 CNV loss 21293372
nsv236940 CNV deletion 16902084
nsv237162 CNV deletion 16902084
nsv834687 CNV loss 17160897

Variation tolerance for RHOA Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOA Gene

Disorders for RHOA Gene

MalaCards: The human disease database

(8) MalaCards diseases for RHOA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
pulmonary hypertension
  • primary pulmonary hypertension
pancreatic cancer
  • pancreatic carcinoma, somatic
gastrointestinal defects and immunodeficiency syndrome
  • multiple intestinal atresia
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search RHOA in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHOA

Genetic Association Database (GAD)
RHOA
Human Genome Epidemiology (HuGE) Navigator
RHOA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOA
genes like me logo Genes that share disorders with RHOA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOA Gene

Publications for RHOA Gene

  1. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur WT … Wennerberg K (The Journal of biological chemistry 2002) 3 4 22 60
  2. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PMID: 11696353) Klussmann E … Rosenthal W (FEBS letters 2001) 3 4 22 60
  3. RHO binding to FAM65A regulates Golgi reorientation during cell migration. (PMID: 27807006) Mardakheh FK … Marshall CJ (Journal of cell science 2016) 3 4 60
  4. Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. (PMID: 25588844) Gao K … Wu D (Journal of cell science 2015) 3 4 60
  5. RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway. (PMID: 20499158) Cao XX … Liu XP (Breast cancer research and treatment 2011) 3 4 60

Products for RHOA Gene

  • Addgene plasmids for RHOA

Sources for RHOA Gene

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