RHOA Gene
protein-coding GIFtS : 69 GCID: GC03 M049371
ras homolog family member A ras homolog gene family, member A )ARH12, ARHA )
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Aliasesfor RHOA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ras Homolog Family Member A 1 2 H121 ARH121 2 3 5 Rho121 ARHA1 2 3 5 RhoA1 RHOH121 2 5 Aplysia Ras-Related Homolog 122 Ras Homolog Gene Family, Member A1 2 Oncogene RHO H122 Rho CDNA Clone 122 3 Small GTP Binding Protein RhoA2 RHO122 3 Transforming Protein RhoA2
Export aliases for RHOA gene to outside databases Previous GC identifer: GC03M049357
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Summariesfor RHOA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586 Function : Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesionsand actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization Gene Wiki entry for RHOA
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Genomic Viewsfor RHOA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RHOA gene promoter:c-Fos GR AP-1 GR-beta STAT5A GR-alpha c-Jun PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for RHOA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3 RHOA Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M049371: view genomic region
(about GC identifiers )
Start: 49,396,578 bp from pter End:
49,450,431 bp from pter
Size: 53,854 bases Orientation:
minus strand
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Proteinsfor RHOA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586 See
protein sequence )Recommended Name: Size : 193 amino acids; 21768 DaCofactor : MagnesiumSubunit : Interacts with ARHGEF28 (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1and RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation. Interacts with GNB2L1/RACK1; enhances RHOA activation. Interacts with PKP4; the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2
Subcellular location : Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow.Cytoplasm, cell cortex. Midbody. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner
6/19 PDB 3D structures from (see all 19 ):1A2B (3D) 1CC0 (3D) 1CXZ (3D) 1DPF (3D) 1FTN (3D) 1KMQ (3D) Secondary accessions : P06749 Q53HM4 Q5U024 Q9UDJ0 Q9UEJ4Explore the universe of human proteins at neXtProt for RHOA: NX_P61586 Post-translational modifications:
Substrate for botulinum ADP-ribosyltransferase1 Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage1
AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo1
Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling1 Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P61586 RHOA Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001655.1 ENSEMBL proteins: ENSP00000400175 ENSP00000394483 ENSP00000413587 ENSP00000408402 ENSP00000400747 Reactome Protein details: P61586 Human Recombinant Protein Products: Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15 ): About this table
About GeneDecksing RHOA Antibody Products: Assay Products for RHOA:
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Protein
Domains /for RHOA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P61586 ProtoNet protein and cluster: P61586
1 Blocks protein family : IPB003577 UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586 Domain : The basic-rich region is essential for yopT recognition and cleavageSimilarity : Belongs to the small GTPase superfamily. Rho family
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Functionfor RHOA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586 Function : Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesionsand actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization Enzyme regulation : GTP hydrolysis is stimulated by ARHGAP30
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RHOA (NM_001664 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHOA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RHOA
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOA
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 9 GenomeRNAi human phenotypes for RHOA :Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rhoa) :About GeneDecksing
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Pathways & Interactionsfor RHOA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/99 super-pathways (see all 99 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell adhesion_Integrin-mediated cell adhesion and migration 2 Wnt Signaling Pathway 3 G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins 4 Cell death signalling via NRAGE, NRIF and NADE 5 Development HGF signaling pathway
Pathway sources See GeneCards unified pathways Show all pathways 5/21 (see all 21 )2 1 5/23 (see all 23 )5/55 (see all 55 ) 5/27 (see all 27 )1 RHOA 5/20 (Kegg details for RHOA) (see all 20 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOA STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/220 Interacting proteins for RHOA (P61586 1 , 2 , 3 ENSP00000400175 4 via UniProtKB, MINT, STRING , and/or I2D (see all 220 )Interactant Interaction Details GeneCard External ID(s) ARHGEF11 O15085 1 , 2 , 3 ENSP00000357177 4 EBI-446668,EBI-311099 MINT-7949741 MINT-7949789 MINT-7949718 MINT-7949764 I2D:
score=6 STRING: ENSP00000357177 DAAM1 Q9Y4D1 1 , 2 , 3 ENSP00000247170 4 EBI-446668,EBI-2817289 MINT-7146254 I2D:
score=3 STRING: ENSP00000247170 NCL P19338 2 , 3 ENSP00000318195 4 MINT-8086635 MINT-8086576 MINT-8086679 MINT-8086602 MINT-8086696 I2D:
score=1 STRING: ENSP00000318195 ROCK1 Q13464 2 , 3 ENSP00000382697 4 MINT-8086576 MINT-8086663 MINT-8086602 I2D:
score=6 STRING: ENSP00000382697 SMURF1 Q9HCE7 2 , 3 ENSP00000354621 4 MINT-56527 MINT-8187339 MINT-8187355 I2D:
score=3 STRING: ENSP00000354621
About this table Gene Ontology (GO): 5/60 biological process terms (GO ID links to tree view) (see all 60 ): About this table
About GeneDecksing
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Drugs & Compoundsfor RHOA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for RHOA
Browse Tocris compounds for RHOA 4 HMDB Compounds for RHOA About this table 1 DrugBank Compound for RHOA About this table 10/107 Novoseek chemical compound relationships for RHOA gene (see all 107 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
geranylgeranyl pyrophosphate
85.4
26
11864926 (2), 16873994 (2), 17947676 (2), 11334884 (1) (see all 16 )
mdi-a
83.6
21
12847276 (4), 12445462 (2), 17307336 (2), 18829452 (1) (see all 11 )
gdp
71.8
39
11342655 (3), 11864926 (2), 9548756 (2), 9199174 (2) (see all 25 )
fasudil
71
5
15980430 (1), 20368772 (1), 16931799 (1), 15627783 (1) (see all 5 )
actomyosin
71
21
17646397 (2), 18086913 (2), 17446864 (1), 19334011 (1) (see all 17 )
mevalonate
70.6
11
11788600 (2), 12427032 (2), 11286990 (1), 17075836 (1) (see all 8 )
gtp
70
100
10716190 (4), 18377644 (3), 12620811 (3), 16914531 (3) (see all 50 )
geranylgeraniol
69.7
6
15951198 (2), 16740276 (1), 10559211 (1), 12771933 (1) (see all 5 )
farnesyl diphosphate
65.4
8
11334884 (1), 11470741 (1), 16858009 (1), 17237547 (1) (see all 5 )
lovastatin
58.8
35
19151402 (7), 20455727 (5), 19038009 (3), 14572607 (2) (see all 15 )
RHOA
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Transcriptsfor RHOA gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RHOA gene: NM_001664.2 Unigene Cluster for RHOA:
Ras homolog family member A Hs.247077 [show with all ESTs ] Unigene Representative Sequence: NM_001664 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000418115 (uc010hku.3 uc003cwu.3 ) ENST00000454011 ENST00000422781 ENST00000445425 ENST00000431929 ENST00000265538 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RHOA (NM_001664 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHOA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RHOA
Additional cDNA sequence: AF498970.1 AK130066.1 AK130808.1 AK222556.1 AK296654.1 AK307220.1 BC000946.3 BC001360.2 BC005976.1 BT019870.1 BX647063.1 L09159.1 L25080.1 X05026.1
24/69 DOTS entries (see all 69 ): DT.100695868 DT.91860959
DT.100695864 DT.100695869 DT.120904554 DT.100695874 DT.97868367 DT.91777469 DT.453628 DT.100695847 DT.100059757 DT.91777425 DT.91777473 DT.100695880 DT.100695892 DT.100695881 DT.91777456 DT.100849651 DT.120904717 DT.120904642 DT.100695902 DT.100853328 DT.100853666 DT.100695876 24/2393 AceView cDNA sequences (see all 2393 ):
BU176604 BI833287 N43006 BM458520 BM457182 BU184649 AV649797 BM786740 BU630913 BQ683809 CA419481 F11465 CB138333 BM769613 AA365164 AA100493 BP350079 BE302415 BE383307 BG742153 AW328532 BM542411 AI992348 CD368422 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for RHOA About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c SP1 : SP2 : - SP3 : - - - SP4 : - - -
ECgene alternative splicing isoforms for RHOA
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Expression for RHOA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RHOA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGTGGCACTC
About this image RHOA expression in embryonic tissues and stem cells About this table See RHOA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RHOA SOURCE GeneReport for Unigene cluster: Hs.247077 SABiosciences Expression via Pathway-Focused PCR Arrays including RHOA (see all 18 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOA
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Orthologsfor RHOA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for RHOA gene from 7/29 species (see all 29 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves RHOA1
ras homolog gene family, member A
83.77(n) 99.48(a)
395442 NM_204704.1 NP_990035.1
lizard Reptilia RHOA6
--
99(a) 96(a)
1 ↔ many1 ↔ many
2(147510464-147522980) 2(68714089-68717651)
African clawed frog Amphibia AF151015.12
--
83.56(n)
AF151015.1
zebrafish Actinopterygii wufc17g012
Danio rerio cDNA clone MGC63939 IMAGE6791145, complete more
81.37(n)
BC054576.1
fruit fly Insecta Rho16
Rho1
87(a)
1 → many
2R(11990191-11994734)
worm Secernentea rho-16
Ras-like GTP-binding protein rhoA
88(a)
possible ortholog
IV(16483178-16488988)
baker's yeast Saccharomycetes RHO11
Rho1p
63.87(n) 72.25(a)
856294 NP_015491.1
ENSEMBL Gene Tree for RHOA (if available)TreeFam Gene Tree for RHOA (if available)
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Paralogsfor RHOA gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RHOA gene RHOB 2 RND1 2 RHOD 2 RHOF 2 RHOC 2 RND3 2 18/98 SIMAP similar genes for RHOA using alignment to 5 protein entries: RHOA_HUMAN (see all proteins )
(see all similar genes ):ARHA RHOB RHOC SUV420H1 EIF3K NEK4 TP63 EEF1E1 FLJ00047 RND3 ARHE AURA2 PUS1 RHOQ UTY RHOF RAC3 NF2 About GeneDecksing 2 Pseudogenes.org Pseudogenes for RHOA PGOHUM00000242390 PGOHUM00000243294
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Genomic Variantsfor RHOA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 3 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for RHOA (49396578 - 49450431 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for RHOA 2 CNVs 6180 6179
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor RHOA gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 165390
OMIM disorders : --20/103 (see all 103 ): About MalaCards cerebral cavernous malformations-2 autosomal dominant nonsyndromic deafness cerebral cavernous malformations cavernous malformation down syndrome critical region non-small cell lung carcinoma adenomatous polyposis coli temporal lobe epilepsy clostridium difficile severe congenital neutropenia clear cell renal cell carcinoma myotonic dystrophy nonsyndromic deafness megakaryoblastic leukemia chronic obstructive pulmonary disease idiopathic pulmonary fibrosis esophageal squamous cell carcinoma renal cell carcinoma cystic fibrosis squamous cell carcinoma 10/68 Novoseek disease relationships for RHOA gene (see all 68 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis
41.1
40
20383141 (3), 17597401 (2), 19550117 (2), 12581011 (2) (see all 23 )
cancer
36.9
48
20383141 (3), 14598891 (3), 15059348 (2), 19499974 (2) (see all 35 )
tumors
32.7
131
8302578 (6), 12855641 (5), 10328216 (4), 17881360 (3) (see all 58 )
cardiac hypertrophy
22
2
15715922 (1), 17468766 (1)
prostate cancer
21.2
12
16402387 (3), 16231705 (2), 19667069 (1), 19302267 (1) (see all 9 )
hypertension pulmonary
17.2
4
16428270 (1), 19416631 (1), 15109211 (1), 19299501 (1)
atherosclerosis
16.6
1
12860900 (1)
carcinoma non-small cell lung
15.9
1
17684444 (1)
gastric cancer
15.7
53
15448013 (7), 19372585 (4), 15059348 (4), 14975755 (4) (see all 11 )
melanoma
15.7
17
18922893 (3), 19293150 (2), 12972558 (2), 12445208 (1) (see all 9 )
Human Genome Epidemiology (HuGE) Navigator: RHOA (14 documents) Export disorders for RHOA gene to outside databases
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Publicationsfor RHOA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RHOA gene, integrated from 9 sources (see all 1272 ):(articles sorted by number of sources associating them with RHOA) Utopia : connect your pdf to the dynamic
The armadillo protein p0071 regulates Rho signalling during cytokinesis. (PubMed id 17115030) 1 , 2 , 9(2006) XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096) 1 , 2 , 9(2002) Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PubMed id 11696353) 1 , 2 , 9(2001) RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway. (PubMed id 20499158) 1 , 2 (2011) Cullin mediates degradation of RhoA through evolution arily conserved BTB adaptors to control actin cytoskeleton structure and cell m ovement. (PubMed id 19782033) 1 , 2 (2009) The Rho-family GEF Asef2 activates Rac to modulate ad hesion and actin dynamics and thereby regulate cell migration. (PubMed id 19934221) 1 , 2 (2009) An ECT2-centralspindlin complex regulates the localization and function of RhoA. (PubMed id 16103226) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. (PubMed id 12538863) 1 , 2 (2003) Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution. (PubMed id 12777804) 1 , 2 (2003)
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External Searches for RHOA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RHOA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing RHOA gene
(According to HUGE )
About This Section --
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Specialized Databases showing RHOA gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for RHOA gene: RHOA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RHOA gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for RHOA OriGene shRNA RFP for RHOA OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for RHOA Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RHOA OriGene 3'-UTR Clone for RHOA OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RHOA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RHOA OriGene Custom Protein Services for RHOA OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHOA QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for RHOA
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RHOA Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOA
ThermoFisher Antibody for RHOA
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RHOA
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and Proteopedia 
for RHOA (
PharmGKB Pathway for 
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
In-situ hybridization
