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RHOA Gene

protein-coding GIFtS: 60

GC03M049371

ras homolog gene family, member A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ARH12, ARHA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
ras homolog gene family, member A¹ ²		Rho12¹
RHOH12¹ ²		RhoA¹
Rho cDNA clone 12² ³		small GTP binding protein RhoA²
RHO12² ³		Aplysia ras-related homolog 12²
h12² ³		transforming protein RhoA²
ARHA² ³		oncogene RHO H12²
ARH12² ³

External Ids:	HGNC: 667¹	Entrez Gene: 387²	Ensembl: ENSG00000067560⁷	UniProtKB: P61586³

Search outside databases for aliases for RHOA gene

Previous GC identifer: GC03M049357

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions

and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the

plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1.

Activated by ARHGEF2, which promotes the exchange of GDP for GTP

Gene Wiki entry for RHOA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHOA gene upstream (promoter) region

:
AP-1 Egr-1 MyoD GR-alpha STAT5A SRF GR-beta PPAR-gamma2 PPAR-gamma1 AhR

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for RHOA:

MePH04941-1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

RHOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M049371: view genomic region (about GC identifiers)

Start:	49,396,578 bp from pter
End:	49,450,431 bp from pter
Size:	53,854 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.11 NT_022517.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586 (See protein sequence)

Recommended Name: Transforming protein RhoA precursor

Size: 193 amino acids; 21768 Da

Cofactor: Magnesium

Subunit: Interacts with RGNEF (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and

RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with DGKQ.

Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced

syncytium formation

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton

Sequence caution: Sequence=BAD96276.1; Type=Erroneous initiation;

PDB structures from and Proteopedia :

1A2B (3D)

1CC0 (3D)

1CXZ (3D)

1DPF (3D)

1FTN (3D)

1KMQ (3D)

1LB1 (3D)

1OW3 (3D)

1S1C (3D)

1TX4 (3D)

1X86 (3D)

1XCG (3D)

2RGN (3D)

Secondary accessions: P06749 Q53HM4 Q5U024 Q9UDJ0 Q9UEJ4

Post-translational modifications:

Substrate for botulinum ADP-ribosyltransferase¹

Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and

leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage¹

AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and

V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase

activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells.

It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments

remain to be done to confirm results in vivo¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001655.1

ENSEMBL proteins:

ENSP00000400175 ENSP00000413587 ENSP00000394483 ENSP00000408402 ENSP00000400747

Human Recombinant Proteins

	Millipore Purified and/or Recombinant RHOA Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for RHOA
	HuPro® and/or Recombinant Proteins from Abnova for RHOA
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Proteins for RHOA
	Novus Biologicals Lysate for RHOA
	Browse Sino Biological Recombinant Proteins

5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005624	membrane fraction	--	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

RHOA for ontologies About GeneDecksing

Antibodies for RHOA:

	Millipore Mono- and Polyclonal Antibodies for the study of RHOA
	Sigma-Aldrich Antibodies for RHOA
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RHOA
	Monoclonal and Polyclonal Antibodies from Abnova (RHOA)
	Origene Antibodies (see all 2): RHOA
	Novus Biologicals Antibodies for RHOA
	Epitomics antibodies for RHOA

Assays for RHOA:

	Millipore Kits and Assays for the Analysis of RHOA
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for RHOA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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RHOA for domains About GeneDecksing

4 InterPro domains/families:

IPR003578 GTPase_Rho

IPR001806 Ras_GTPase

IPR005225 Small_GTP_bd

IPR013753 Ras

Graphical View of Domain Structure for InterPro Entry P61586

ProtoNet protein and cluster: P61586

1 Blocks protein family: IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586

Domain: The basic-rich region is essential for yopT recognition and cleavage

Similarity: Belongs to the small GTPase superfamily. Rho family

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHOA)
		Origene 29mer shRNA kits in GFP-retroviral vector: RHOA Origene shRNA RFP: RHOA Origene basic RS shRNA: RHOA
		Applied Biosystems Silencer® siRNAs for RHOA
		Sigma-Aldrich siRNA Panels and siRNA for RHOA Sigma-Aldrich shRNA Panels and shRNA for RHOA Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: RHOA Origene Myc/DDK tagged cDNA clones in CMV expression vector: RHOA Origene untagged cDNA clones in CMV expression vector: RHOA
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586

Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions

and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the

plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1.

Activated by ARHGEF2, which promotes the exchange of GDP for GTP

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	--	--
GO:0003924	GTPase activity	TAS	10436159
GO:0005515	protein binding	IPI	10051605 10066731 10619026 11335720 11889037 11927263 12006984 12879077 15644318 15670823 17353931
GO:0005525	GTP binding	IEA	--

About this table

RHOA for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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RHOA for pathways About GeneDecksing

5/21 Millipore Pathways for RHOA (see all 21 )

	Chemotaxis CXCR4 signaling pathway
	Translation Translation regulation by Alpha-1 adrenergic receptors
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cytoskeleton remodeling FAK signaling
	Cytoskeleton remodeling Role of PDGFs in cell migration

5/33 Sigma-Aldrich "Your Favorite Gene" Pathways for RHOA (Your Favorite Gene powered by Ingenuity) (see all 33 )

	HMGB1 Signaling
	Glioma Invasiveness Signaling
	Tight Junction Signaling
	Protein Kinase A Signaling
	Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

5/60 GeneAssist Pathways for RHOA (see all 60 )

	NgR-p75(NTR)-Mediated Signaling
	Glioma Invasiveness
	CCKBR-Gastrin Stimulated Signaling
	Crosstalk Between CARM1 and ESRs
	HMGB1 Pathway

1 Cell Signaling Technology (CST) Pathway for RHOA:

T Cell Receptor Signaling

5/15 Kegg Pathways (Kegg details for RHOA) (see all 15 ):

	hsa04062 Chemokine signaling pathway
	hsa04270 Vascular smooth muscle contraction
	hsa04310 Wnt signaling pathway
	hsa04350 TGF-beta signaling pathway
	hsa04360 Axon guidance

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RHOA

5/22 Interacting proteins for RHOA (P61586^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CNKSR1	Q969H4¹^,²	EBI-446668,EBI-741671 MINT-56522 MINT-56518 MINT-56516 MINT-56519 EBI-446668,EBI-741671 MINT-56522 MINT-56518 MINT-56516 MINT-56519
RTKN	Q9BST9¹^,²	EBI-446668,EBI-446694 MINT-6504377 MINT-7301170 MINT-7146266 EBI-446668,EBI-446694 MINT-6504377 MINT-7301170 MINT-7146266
ARHGAP1	Q07960¹	EBI-446668,EBI-602762
ARHGDIA	P52565¹	EBI-446668,EBI-712693
ARHGEF5	Q12774¹	EBI-446668,EBI-602199

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5/46 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 46 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000902	cell morphogenesis	IEA	--
GO:0001666	response to hypoxia	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006886	intracellular protein transport	--	--
GO:0006913	nucleocytoplasmic transport	--	--

About this table

RHOA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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RHOA for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for RHOA

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RHOA
10/340 Novoseek chemical compound relationships for RHOA gene (see all 340 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	46.80	88	10716190 (5), 9548756 (3), 9199174 (3), 18377644 (3) (see all 63)
mdi-a	39.15	18	12847276 (4), 12445462 (2), 12034774 (2), 19160018 (1) (see all 13)
geranylgeranyl pyrophosphate	35.62	28	17322412 (4), 17947676 (2), 16873994 (2), 11864926 (2) (see all 22)
simvastatin	25.15	46	16858009 (5), 16740276 (4), 17237547 (3), 17075836 (3) (see all 24)
lovastatin	22.80	35	19151402 (7), 18296496 (4), 10440923 (4), 19038009 (3) (see all 18)
gdp	22.47	34	11342655 (3), 9548756 (2), 9199174 (2), 11864926 (2) (see all 27)
fasudil	18.37	16	15262212 (3), 19550117 (2), 15924788 (2), 20368772 (1) (see all 12)
gtp gamma s	17.45	25	9666307 (6), 9113419 (3), 2153899 (3), 14615385 (3) (see all 12)
actomyosin	15.66	22	18086913 (2), 17646397 (2), 9478968 (1), 20348415 (1) (see all 20)
sphingosine 1-phosphate	12.42	20	11483412 (6), 17825823 (4), 16510307 (3), 12525155 (2) (see all 8)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHOA)
		Applied Biosystems Silencer® siRNAs: NM_001664
		Origene 29mer shRNA kits in GFP-retroviral vector: RHOA Origene shRNA RFP: RHOA Origene basic RS shRNA: RHOA
		Sigma-Aldrich siRNA Panels and siRNA for RHOA Sigma-Aldrich shRNA Panels and shRNA for RHOA Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		7 SABiosciences microRNAs that regulate RHOA:
		hsa-miR-142-5p hsa-miR-200c hsa-miR-361-5p hsa-miR-429 hsa-miR-185 hsa-miR-485-3p hsa-miR-381

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_001664

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: RHOA
Origene Myc/DDK tagged cDNA clones in CMV expression vector: RHOA
Origene untagged cDNA clones in CMV expression vector: RHOA

Primers:		Origene genome-wide validated SYBR primer pairs: RHOA
		SABiosciences RT2 qPCR Primer Assay for RHOA: PPH00305A

REFSEQ mRNAs for RHOA gene:

NM_001664.2

Additional cDNA sequence:

AF498970.1 AK130066.1 AK130808.1 AK222556.1 AK296654.1 AK307220.1 BC000946.3 BC001360.2

BC005976.1 BT019870.1 BX647063.1 CR590795.1 CR591837.1 CR592238.1 CR594903.1 CR595507.1

CR595947.1 CR596439.1 CR596598.1 CR596885.1 CR598647.1 CR600849.1 CR601531.1 CR602199.1

CR602563.1 CR602766.1 CR602977.1 CR605973.1 CR607421.1 CR607713.1 CR608339.1 CR608641.1

CR610129.1 CR610290.1 CR613062.1 CR614049.1 CR617634.1 CR620398.1 CR621617.1 CR623439.1

CR624260.1 CR624876.1 L09159.1 L25080.1 X05026.1

24/69 DOTS entries (see all 69 ):

DT.91860959 DT.100695868 DT.100695864 DT.100695869 DT.97868367 DT.120904554 DT.100695874 DT.453628

DT.100695847 DT.91777425 DT.100059757 DT.91777469 DT.91777473 DT.91777456 DT.100695880 DT.100695892

DT.100849651 DT.100695881 DT.120904642 DT.100695902 DT.120904717 DT.100853328 DT.100853666 DT.100695876

24/2393 AceView cDNA sequences (see all 2393 ):

BC001360 BQ683364 BG258331 F02985 AA357833 BU165570 N33344 AI359614

BF437596 CR610290 AU142544 BM800293 BU627544 BQ935282 BF343214 BM479295

BM451075 BM042413 BU175725 NM_201397 BE550806 BM467898 AU143571 BX091260

highest scoring ESTs for RHOA:

L25080 AA182690 AA247174 AA295595 AA307327 AA314467 AA315468 AA315470 AA353360 AA353622

Unigene Cluster for RHOA:

Ras homolog gene family, member A

Hs.247077 [show with all ESTs]

Unigene Representative Sequence: NM_001664

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RHOA

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:
SP2:							-
SP3:					-		-		-
SP4:							-		-		-

About this scheme

ECgene alternative splicing isoforms for RHOA

6 Ensembl transcripts including schematic representations:

ENST00000418115 ENST00000422781 ENST00000454011 ENST00000445425 ENST00000431929 ENST00000265538

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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RHOA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RHOA

¹ / ² / ³

5 probe-sets matching RHOA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37309_at²^{, 3}	U95-A	1	0.75	1.00	0.89	1.08	L09159	0.80	1.00	0.91	1
1394_at²^{, 3}	U95-A	1	0.62	1.00	0.98	0.92	L25080	1.00	1.00	1.00	1
200059_s_at²^{, 3}	U133-B	1	0.82	1.00	--	--	BC001360	0.80	1.00	0.91	1
1555814_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200059_s_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

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RHOA for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: GGTGGCACTC

SOURCE GeneReport for Unigene cluster: Hs.247077

Expression variation in blood from EXPOLDB for RHOA

Primers:		Origene genome-wide validated SYBR primer pairs: RHOA
		SABiosciences RT2 qPCR Primer Assay for RHOA: PPH00305A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for RHOA gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RHOA¹	--	ras homolog gene family, member A	95.34(n) 100(a)	403954 XM_850493.1 XP_855586.1
chimpanzee (Pan troglodytes)	RHOA¹	--	ras homolog gene family, member A	100(n) 100(a)	461014 XM_001163811.1 XP_001163811.1
cow (Bos taurus)	RHOA¹	--	ras homolog gene family, member A	93.96(n) 100(a)	338049 NM_176645.3 NP_788818.1
rat (Rattus norvegicus)	Rhoa¹	--	ras homolog gene family, member A	94.13(n) 99.48(a)	117273 NM_057132.2 NP_476473.1
mouse (Mus musculus)	Rhoa^{1, 5}	9⁵	ras homolog gene family, member A^{1, 5}	93.78(n)¹ 99.48(a)¹	11848¹ NM_016802.3¹ NP_058082.2¹ AF014371⁵ AF178958⁵ (see all 22)

About this table Species with no ortholog for RHOA

ENSEMBL Gene Tree for RHOA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for RHOA gene

RHOB² RND1² RHOD² RHOF² RHOC² RND3² RND2²

RHOA for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/214 NCBI SNPs in RHOA are shown (see all 214 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
--	rs12488416^1,2	C,F,H	49509616(+)	`GCAGGC/TTCTGC`	1	--	ng5¹		1	NA	4
--	rs11552761^1,2	H	49412973(-)	`CTGTGG/AAAAGA`	2	/E /G	mis¹ ref¹ ese³		4	NS EA	406
--	rs11552762^1,2	H	49412927(-)	`CCAGAG/TGTGTA`	2	E D	ref¹ mis¹ ese³		4	NS EA	404
	rs974495^1,2	C,F,O,A,H	49459959(-)	`AAAGAG/ACATGT`	1	--	int¹ trp³		14	NS EA NA WA	755
--	rs10155014^1,2	C,F,A,H	49491929(+)	`GGTAAT/CGATGG`	1	--	int¹		7	EA NA	342
--	rs4955412^1,2	C,F,A,H	49477747(-)	`TAGTTT/GTGATA`	1	--	int¹		2	NA WA	52
--	rs7623659^1,2	C,F,A,H	49474374(+)	`gaggcC/Tgaaac`	1	--	int¹		5	NA WA	128
--	rs6446264^1,2	C,F,A,H	49476828(+)	`cgcacC/Acagcc`	1	--	int¹		4	NA	80
--	rs6793308^1,2	C,F,A,H	49483863(+)	`gctcaT/Cgcctg`	1	--	int¹		3	NA	6
	rs2878298^1,2	C,F,A,H	49406080(+)	`GACCAT/CTGAAA`	1	--	int¹		7	NA	262

About this table

HapMap Linkage Disequilibrium images for RHOA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RHOA
2 CNVs: 6180 6179

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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RHOA for disorders About GeneDecksing

OMIM: 165390

10/240 Novoseek disease relationships for RHOA gene (see all 240 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dominant-negative mutant	17.06	17	9042860 (1), 19421144 (1), 18845763 (1), 18688043 (1) (see all 17)
cell transformation	7.32	16	18445682 (2), 9988689 (1), 9822605 (1), 9444953 (1) (see all 15)
escc	6.45	16	16750623 (6), 17896152 (5), 15837049 (5)
gefs+	5.86	5	9030518 (2), 18996344 (1), 18653465 (1), 12423633 (1)
acute megakaryoblastic leukemia	4.27	6	15953360 (4), 8608802 (1), 17699722 (1)
apert	3.45	3	11315998 (3)
cardiac hypertrophy	3.24	13	15715922 (3), 19799911 (2), 19800872 (1), 19779471 (1) (see all 10)
intestinal adenocarcinoma	2.41	2	15723712 (2)
astrocytoma	2.19	12	12237846 (5), 16978776 (2), 20156433 (1), 18687805 (1) (see all 7)
urological cancer	2.10	3	12581011 (3)

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Human Genome Epidemiology Navigator: RHOA (7 documents)

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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1273 PubMed articles for RHOA gene (see all 1273 ):

Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution. (PubMed id 12777804)^{1, 3, 4} Longenecker K....Derewenda Z.S. (2003)
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096)^{1, 3, 4} Arthur W.T.... Wennerberg K. (2002)
Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PubMed id 11696353)^{1, 3, 4} Klussmann E.... Rosenthal W. (2001)
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. (PubMed id 8641286)^{1, 3, 4} Matsui T.... Kaibuchi K. (1996)
Utilization of multiple polyadenylation signals in the human RHOA protooncogene. (PubMed id 8039707)^{1, 3, 4} Moscow J.A.... Cowan K.H. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. (PubMed id 12538863)^{3, 4} Shao F.... Dixon J.E. (2003)
Direct activation of phospholipase C-epsilon by Rho. (PubMed id 12900402)^{3, 4} Wing M.R.... Harden T.K. (2003)
A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. (PubMed id 12062101)^{3, 4} Shao F.... Dixon J.E. (2002)
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. (PubMed id 12006984)^{3, 4} Snyder J.T.... Sondek J. (2002)

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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 387	HGNC: 667	AceView: RHOA	Ensembl:ENSG00000067560	euGenes: HUgn387
ECgene: RHOA	Kegg: 387	H-InvDB: RHOA

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for RHOA	Genetics and Cytogenetics in Oncology and Haematology

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(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for RHOA gene:

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protein-coding GIFtS: 60

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