Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOA Gene

protein-coding   GIFtS: 70
GCID: GC03M049371

Ras Homolog Family Member A

(Previous names: ras homolog gene family, member A)
(Previous symbols: ARH12, ARHA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Homolog Family Member A1 2     h122 3
ARH121 2 3 5     RHOH122 5
ARHA1 2 3 5     Aplysia Ras-Related Homolog 122
Ras Homolog Gene Family, Member A1 2     Oncogene RHO H122
Rho CDNA Clone 122 3     Small GTP Binding Protein RhoA2
RHO122 3     Transforming Protein RhoA2

External Ids:    HGNC: 6671   Entrez Gene: 3872   Ensembl: ENSG000000675607   OMIM: 1653905   UniProtKB: P615863   

Export aliases for RHOA gene to outside databases

Previous GC identifer: GC03M049357


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RHOA Gene: 
RHOA (ras homolog family member A) is a protein-coding gene. Diseases associated with RHOA include cerebral cavernous malformations-2, and autosomal dominant nonsyndromic deafness, and among its related super-pathways are Development Slit-Robo signaling and Wnt signaling pathway. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586
Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal
adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin
contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation.
Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT
cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes
gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2,
which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and
adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in
ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2
to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization
of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization

Gene Wiki entry for RHOA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOA gene promoter:
         c-Fos   GR   AP-1   GR-beta   STAT5A   GR-alpha   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOA promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

RHOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049371:  view genomic region     (about GC identifiers)

Start:
49,396,578 bp from pter      End:
49,450,431 bp from pter
Size:
53,854 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586 (See protein sequence)
Recommended Name: Transforming protein RhoA precursor  
Size: 193 amino acids; 21768 Da
Cofactor: Magnesium
Subunit: Interacts with ARHGEF28 (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3,
NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with
DGKQ. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates
virus-induced syncytium formation. Interacts with GNB2L1/RACK1; enhances RHOA activation. Interacts with PKP4;
the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction
stimulates autophosphorylation and phosphorylation of PKN2
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow.
Cytoplasm, cell cortex. Midbody. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By
similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes
to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and
in a myosin- and actin-independent manner
6/19 PDB 3D structures from and Proteopedia for RHOA (see all 19):
1A2B (3D)        1CC0 (3D)        1CXZ (3D)        1DPF (3D)        1FTN (3D)        1KMQ (3D)    
Secondary accessions: P06749 Q53HM4 Q5U024 Q9UDJ0 Q9UEJ4

Explore the universe of human proteins at neXtProt for RHOA: NX_P61586

Explore proteomics data for RHOA at MOPED 

Post-translational modifications:

  • UniProtKB: Substrate for botulinum ADP-ribosyltransferase
  • UniProtKB: Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment,
    and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage
  • UniProtKB: AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and
    V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the
    GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in
    infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but
    additional experiments remain to be done to confirm results in vivo
  • UniProtKB: Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling
  • UniProtKB: Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by
    the proteasome, thereby regulating the actin cytoskeleton and cell migration
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61586

  • RHOA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOA Protein Expression
    REFSEQ proteins: NP_001655.1  
    ENSEMBL proteins: 
     ENSP00000400175   ENSP00000394483   ENSP00000413587   ENSP00000408402   ENSP00000400747  
    Reactome Protein details: P61586
    Human Recombinant Protein Products for RHOA: 
    EMD Millipore Purified and/or Recombinant RHOA Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RHOA
    OriGene Protein Over-expression Lysate for RHOA
    OriGene MassSpec for RHOA 
    OriGene Custom Protein Services for RHOA
    GenScript Custom Purified and Recombinant Proteins Services for RHOA
    Novus Biologicals RHOA Proteins
    Novus Biologicals RHOA Lysates
    Sino Biological Recombinant Protein for RHOA
    Sino Biological Cell Lysate for RHOA 
    ProSpec Recombinant Protein for RHOA
    Cloud-Clone Corp. Proteins for RHOA 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    RHOA for ontologies           About GeneDecksing



    RHOA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RHOA
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RHOA 
    OriGene Antibodies for RHOA
    OriGene Custom Antibody Services for RHOA
    GenScript Custom Superior Antibodies Services for RHOA
    Novus Biologicals RHOA Antibodies
    Abcam antibodies for RHOA
    Cloud-Clone Corp. Antibodies for RHOA 
    ThermoFisher Antibody for RHOA
    LSBio Antibodies in human, mouse, rat for RHOA 

    Assay Products for RHOA: 
    EMD Millipore Kits and Assays for the Analysis of RHOA
    OriGene Custom Assay Services for RHOA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RHOA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOA 
    Cloud-Clone Corp. CLIAs for RHOA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P61586

    ProtoNet protein and cluster: P61586

    1 Blocks protein domain: IPB003577 Ras small GTPase

    UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586
    Domain: The basic-rich region is essential for yopT recognition and cleavage
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOA_HUMAN, P61586
    Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal
    adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin
    contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation.
    Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT
    cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes
    gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2,
    which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and
    adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in
    ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2
    to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization
    of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization
    Enzyme regulation: GTP hydrolysis is stimulated by ARHGAP30

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10436159
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IEA--
    GO:0017022myosin binding IPI15644318
    GO:0019904protein domain specific binding IEA--
         
    RHOA for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for RHOA:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased focal adhesion (FA)  
     Decreased homologous recombina  Increased Salmonella enterica   Increased gamma-H2AX phosphory  Stronger migration 
     Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rhoa):
     cellular  embryogenesis  mortality/aging  nervous system 

    RHOA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOA:
    hsa-mir-31 (MIRT000088), hsa-mir-155 (MIRT001961), hsa-mir-185 (MIRT004036), hsa-mir-122 (MIRT000717)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOA
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOA (see all 14):
    hsa-miR-142-5p hsa-miR-577 hsa-miR-429 hsa-miR-548e hsa-miR-340 hsa-miR-548a-3p hsa-miR-183* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidRHOA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOA
    Sirion Biotech Customized adenovirus for overexpression of RHOA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RHOA (see all 7)
    OriGene ORF clones in mouse, rat for RHOA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOA (NM_001664)
    Sino Biological Human cDNA Clone for RHOA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOA
    Sirion Biotech Customized lentivirus for stable overexpression of RHOA 
                         Customized lentivirus expression plasmids for stable overexpression of RHOA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RHOA
    Search LifeMap BioReagents cell lines for RHOA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHOA About   (see all 109)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    3Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    4Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    5Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/21 EMD Millipore Pathways for RHOA (see all 21)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling FAK signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration

    3 R&D Systems Pathways for RHOA
        Wnt Signaling Pathway
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    TGF-beta Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for RHOA
        Cytoskeletal Signaling

    5/23 GeneGo (Thomson Reuters) Pathways for RHOA (see all 23)
        Cytoskeleton remodeling Role of PDGFs in cell migration
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Chemotaxis CXCR4 signaling pathway
    Development Slit-Robo signaling

    5/56 BioSystems Pathways for RHOA (see all 56)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Wnt Signaling Pathway
    G13 Signaling Pathway
    DNA damage response (only ATM dependent)

    3 Sino Biological Pathways for RHOA 
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    TGF-beta Signaling Pathway

    5/26        Reactome Pathways for RHOA (see all 26)
        Axonal growth inhibition (RHOA activation)
    Developmental Biology
    G alpha (12/13) signalling events
    p75NTR regulates axonogenesis
    p75 NTR receptor-mediated signalling

    1 PharmGKB Pathway for RHOA
        Bisphosphonate Pathway, Pharmacodynamics

    5/23         Kegg Pathways  (Kegg details for RHOA) (see all 23):
        Chemokine signaling pathway
    Endocytosis
    Vascular smooth muscle contraction
    Wnt signaling pathway
    TGF-beta signaling pathway


    RHOA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/234 Interacting proteins for RHOA (P615861, 2, 3 ENSP000004001754) via UniProtKB, MINT, STRING, and/or I2D (see all 234)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072, 3MINT-8086576 I2D: score=3 
    ENSG00000215328P081072, 3MINT-8086576 I2D: score=3 
    ENSG00000224501P081072, 3MINT-8086576 I2D: score=3 
    ENSG00000231555P081072, 3MINT-8086576 I2D: score=3 
    ENSG00000232804P081072, 3MINT-8086576 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/62 biological process terms (GO ID links to tree view) (see all 62):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0001666response to hypoxia IEA--
    GO:0006184GTP catabolic process ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007155cell adhesion ----

    RHOA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOA for compounds           About GeneDecksing

    EMD Millipore small molecules for RHOA:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for RHOA

    Browse Tocris compounds for RHOA

    4 HMDB Compounds for RHOA    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    1 DrugBank Compound for RHOA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235

    10/107 Novoseek inferred chemical compound relationships for RHOA gene (see all 107)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geranylgeranyl pyrophosphate 85.4 26 11864926 (2), 16873994 (2), 17947676 (2), 11334884 (1) (see all 16)
    mdi-a 83.6 21 12847276 (4), 12445462 (2), 17307336 (2), 18829452 (1) (see all 11)
    gdp 71.8 39 11342655 (3), 11864926 (2), 9548756 (2), 9199174 (2) (see all 25)
    fasudil 71 5 15980430 (1), 20368772 (1), 16931799 (1), 15627783 (1) (see all 5)
    actomyosin 71 21 17646397 (2), 18086913 (2), 17446864 (1), 19334011 (1) (see all 17)
    mevalonate 70.6 11 11788600 (2), 12427032 (2), 11286990 (1), 17075836 (1) (see all 8)
    gtp 70 100 10716190 (4), 18377644 (3), 12620811 (3), 16914531 (3) (see all 50)
    geranylgeraniol 69.7 6 15951198 (2), 16740276 (1), 10559211 (1), 12771933 (1) (see all 5)
    farnesyl diphosphate 65.4 8 11334884 (1), 11470741 (1), 16858009 (1), 17237547 (1) (see all 5)
    lovastatin 58.8 35 19151402 (7), 20455727 (5), 19038009 (3), 14572607 (2) (see all 15)

    Search CenterWatch for drugs/clinical trials and news about RHOA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHOA gene: 
    NM_001664.2  

    Unigene Cluster for RHOA:

    Ras homolog family member A
    Hs.247077  [show with all ESTs]
    Unigene Representative Sequence: NM_001664
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418115(uc010hku.3 uc003cwu.3) ENST00000454011 ENST00000422781
    ENST00000445425 ENST00000431929 ENST00000265538
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOA
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOA (see all 14):
    hsa-miR-142-5p hsa-miR-577 hsa-miR-429 hsa-miR-548e hsa-miR-340 hsa-miR-548a-3p hsa-miR-183* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidRHOA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOA
    Clone
    Products:
         
    OriGene clones in human, mouse for RHOA (see all 7)
    OriGene ORF clones in mouse, rat for RHOA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOA (NM_001664)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOA
    Sirion Biotech Customized lentivirus for stable overexpression of RHOA 
                         Customized lentivirus expression plasmids for stable overexpression of RHOA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOA
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOA

    Additional mRNA sequence: 

    AF498970.1 AK130066.1 AK130808.1 AK222556.1 AK296654.1 AK307220.1 BC000946.3 BC001360.2 
    BC005976.1 BT019870.1 BX647063.1 L09159.1 L25080.1 X05026.1 

    24/72 DOTS entries (see all 72):

    DT.91860959  DT.100695868  DT.100695864  DT.100695869  DT.120904554  DT.97868367  DT.100695874  DT.453628 
    DT.100695847  DT.91777425  DT.100059757  DT.91777469  DT.91777473  DT.91777456  DT.100695880  DT.100695892 
    DT.100849651  DT.100695881  DT.120904642  DT.100695902  DT.120904717  DT.100853328  DT.100853666  DT.91645983 

    24/2393 AceView cDNA sequences (see all 2393):

    AU143571 BX091260 BM467898 BE278892 W07744 AU157538 BQ776172 AA315468 
    BQ893583 BF968073 BM802690 BX443723 BU187905 CR600849 BQ027088 BC000742 
    BM558337 CR601795 BU147094 BG222854 BM802479 BX463867 BQ718593 CR608641 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RHOA    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:                    -                                 
    SP3:              -     -     -                           
    SP4:                    -     -     -                     


    ECgene alternative splicing isoforms for RHOA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOA expression in normal human tissues (normalized intensities)      RHOA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGCACTC
    RHOA Expression
    About this image


    RHOA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Pancreas (Endocrine System)
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Kidney (Reproductive System)
             visceral organ/mesonephros of female/mesonephric mesenchyme of female mesonephros   
     
     Brain (Nervous System)
             brain/hindbrain   

    See RHOA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOA

    SOURCE GeneReport for Unigene cluster: Hs.247077
        SABiosciences Expression via Pathway-Focused PCR Arrays including RHOA (see all 18): 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Wound Healing in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHOA
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOA gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhoa1 , 5 ras homolog gene family, member A1, 5 93.78(n)1
    99.48(a)1
      9 (59.20 cM)5
    118481  NM_016802.41  NP_058082.21 
     1083062055 
    chicken
    (Gallus gallus)
    Aves RHOA1 ras homolog gene family, member A 83.77(n)
    99.48(a)
      395442  NM_204704.1  NP_990035.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOA6
    --
    --
    99(a)
    88(a)
    1 ↔ 1
    possible ortholog
    2(147510464-147522987)
    2(68689850-68727433)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF151015.12   -- 83.56(n)    AF151015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17g012 Danio rerio cDNA clone MGC63939 IMAGE6791145, complete more 81.37(n)    BC054576.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rho16
    Rho1
    87(a)
    1 → many
    2R(11990191-11994734)
    worm
    (Caenorhabditis elegans)
    Secernentea rho-16
    Ras-like GTP-binding protein rhoA
    88(a)
    1 → many
    IV(16483211-16489021)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHO11 Rho1p 63.87(n)
    72.25(a)
      856294   NP_015491.1 


    ENSEMBL Gene Tree for RHOA (if available)
    TreeFam Gene Tree for RHOA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOA gene
    RHOB2  RND12  RHOD2  RHOF2  RHOC2  ENSG000002718102  RND22  RND32  
    18/95 SIMAP similar genes for RHOA using alignment to 5 protein entries:     RHOA_HUMAN (see all proteins) (see all similar genes):
    ARHA    RHOB    RHOC    SUV420H1    EIF3K    NEK4
    TP63    EEF1E1    FLJ00047    RND3    ARHE    AURA2
    PUS1    RHOQ    UTY    RHOF    RAC3    NF2

    RHOA for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RHOA
    PGOHUM00000242390 PGOHUM00000243294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/987 SNPs in RHOA are shown (see all 987)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573540411,2
    C--49370941(+) AAAAA-/AAAAAAAA
    /AAAAAAAAA
    GAGTT
    2 -- int1 cds11NA 2
    rs2006172341,2
    --49397900(+) AAAGA-/TTTTTT 1 -- int10--------
    rs1381052141,2
    --49397911(+) TTTTCC/TTTTTT 1 -- int10--------
    rs1927241661,2
    C--49397936(+) TCGTCA/GGTCGC 1 -- int10--------
    rs1495400491,2
    C--49397959(+) GCAATA/GGCATG 1 -- int10--------
    rs1848813641,2
    --49398220(+) GCTGTC/TAAACT 1 -- int10--------
    rs1884471281,2
    --49398448(+) TTGCAC/GTTGAG 1 -- int10--------
    rs1143008001,2
    F--49398464(+) ATCGTG/ACCACA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs3752863981,2
    C--49398505(+) TTCTC-/AAAAAA 1 -- int10--------
    rs8929741,2
    C,H--49398514(-) GTTTTT/GTTTTT 1 -- int17Minor allele frequency- G:0.07NA WA CSA 14

    HapMap Linkage Disequilibrium report for RHOA (49396578 - 49450431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RHOA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv236940CNV Loss16902084
    nsv834687CNV Loss17160897
    nsv237162CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOA
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165390    OMIM disorders: --

    20/93 diseases for RHOA (see all 93):    About MalaCards
    cerebral cavernous malformations-2    autosomal dominant nonsyndromic deafness    plague    gitelman syndrome
    down syndrome critical region    nonsyndromic deafness    severe congenital neutropenia    tangier disease
    clostridium difficile    cavernous malformation    cerebral cavernous malformation    blastoma
    myotonic dystrophy    neuritis    neutropenia    pemphigus
    glioblastoma    testicular cancer    clear cell renal cell carcinoma    lissencephaly


    RHOA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/68 Novoseek inferred disease relationships for RHOA gene (see all 68)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 41.1 40 20383141 (3), 17597401 (2), 19550117 (2), 12581011 (2) (see all 23)
    cancer 36.9 48 20383141 (3), 14598891 (3), 15059348 (2), 19499974 (2) (see all 35)
    tumors 32.7 131 8302578 (6), 12855641 (5), 10328216 (4), 17881360 (3) (see all 58)
    cardiac hypertrophy 22 2 15715922 (1), 17468766 (1)
    prostate cancer 21.2 12 16402387 (3), 16231705 (2), 19667069 (1), 19302267 (1) (see all 9)
    hypertension pulmonary 17.2 4 16428270 (1), 19416631 (1), 15109211 (1), 19299501 (1)
    atherosclerosis 16.6 1 12860900 (1)
    carcinoma non-small cell lung 15.9 1 17684444 (1)
    gastric cancer 15.7 53 15448013 (7), 19372585 (4), 15059348 (4), 14975755 (4) (see all 11)
    melanoma 15.7 17 18922893 (3), 19293150 (2), 12972558 (2), 12445208 (1) (see all 9)

    Genetic Association Database (GAD): RHOA
    Human Genome Epidemiology (HuGE) Navigator: RHOA (14 documents)

    Export disorders for RHOA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOA gene, integrated from 9 sources (see all 1308):
    (articles sorted by number of sources associating them with RHOA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The armadillo protein p0071 regulates Rho signalling during cytokinesis. (PubMed id 17115030)1, 2, 9 Wolf A.... Hatzfeld M. (2006)
    2. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096)1, 2, 9 Arthur W.T.... Wennerberg K. (2002)
    3. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PubMed id 11696353)1, 2, 9 Klussmann E.... Rosenthal W. (2001)
    4. RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway. (PubMed id 20499158)1, 2 Cao X.X....Liu X.P. (2011)
    5. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (2010)
    6. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    9. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387 HGNC: 667 AceView: RHOA Ensembl:ENSG00000067560 euGenes: HUgn387
    ECgene: RHOA Kegg: 387 H-InvDB: RHOA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHOA gene:
    Search GeneIP for patents involving RHOA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Kits and Assays for the Analysis of RHOA
     EMD Millipore Purified and/or Recombinant RHOA Protein
     EMD Millipore small molecules (inhibitor) for RHOA
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RHOA
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RHOA   OriGene RNAi products in human, mouse, rat for RHOA  
     OriGene qPCR primer pairs and template standards for RHOA   OriGene Protein Over-expression Lysate for RHOA  
     OriGene MassSpec something-or-other for RHOA   OriGene clones in human, mouse for RHOA  
     OriGene qSTAR qPCR primer pairs in human, mouse for RHOA   OriGene Purified Protein for RHOA  
     OriGene ORF clones in mouse, rat for RHOA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RHOA   OriGene Custom Protein Services for RHOA  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHOA
     QIAGEN SeqTarget long-range PCR primers for resequencing RHOA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOA
     GenScript Custom Purified and Recombinant Proteins Services for RHOA GenScript cDNA clones with any tag delivered in your preferred vector for RHOA
     GenScript Custom Assay Services for RHOA GenScript Custom Superior Antibodies Services for RHOA
     GenScript Custom overexpressing Cell Line Services for RHOA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RHOA 

     Regulatory tfbs in RHOA promoter
     Search Chromatin IP Primers for RHOA
     RT2 qPCR Primer Assay in human, mouse, rat RHOA
     GNC Network for RHOA
     SABiosciences PCR Arrays including human, mouse, rat RHOA
     Search Tocris compounds for RHOA
     Proteins and Antibodies for RHOA
     Cell Lysates for RHOA
     cDNA Clones for RHOA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for RHOA
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RHOA antibodies
     RHOA proteins
     RHOA lysates
     Antibodies for RHOA
     See all of Abcam's Antibodies, Kits and Proteins for RHOA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RHOA




     Proteins for RHOA
     Antibodies for RHOA
     ELISAs for RHOA
     CLIAs for RHOA
     Search LifeMap BioReagents cell lines for RHOA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOA
     SwitchGear 3'UTR luciferase reporter plasmids for RHOA
     SwitchGear Promoter luciferase reporter plasmids for RHOA
     ThermoFisher Antibody for RHOA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOA
    Customized:
     lentivirus for stable overexpression of RHOA
     lentivirus expression plasmids for stable overexpression of RHOA
     adenovirus for overexpression of RHOA
     LSBio Antibodies in human, mouse, rat for RHOA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RHOA gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4