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RHOA Gene

protein-coding   GIFtS: 70
GCID: GC03M049397

Ras Homolog Family Member A

(Previous names: ras homolog gene family, member A)
(Previous symbols: ARH12, ARHA)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member A1 2     h122 3
ARH121 2 3 5     RHOH122 5
ARHA1 2 3 5     Aplysia Ras-Related Homolog 122
Ras Homolog Gene Family, Member A1 2     Oncogene RHO H122
Rho CDNA Clone 122 3     Small GTP Binding Protein RhoA2
RHO122 3     Transforming Protein RhoA2

External Ids:    HGNC: 6671   Entrez Gene: 3872   Ensembl: ENSG000000675607   OMIM: 1653905   UniProtKB: P615863   

Export aliases for RHOA gene to outside databases

Previous GC identifers: GC03M049357 GC03M049371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHOA Gene:
RHOA (ras homolog family member A) is a protein-coding gene. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586
Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal
adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin
contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation.
Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT
cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes
gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2,
which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and
adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in
ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2
to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization
of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization

Gene Wiki entry for RHOA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOA gene promoter:
         c-Fos   GR   AP-1   GR-beta   STAT5A   GR-alpha   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOA promoter sequence
   Search Chromatin IP Primers for RHOA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

RHOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOA gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049397:  view genomic region     (about GC identifiers)

Start:
49,396,578 bp from pter      End:
49,450,431 bp from pter
Size:
53,854 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586 (See protein sequence)
Recommended Name: Transforming protein RhoA precursor  
Size: 193 amino acids; 21768 Da
Cofactor: Magnesium
Subunit: Interacts with ARHGEF28 (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3,
NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with
DGKQ. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates
virus-induced syncytium formation. Interacts with GNB2L1/RACK1; enhances RHOA activation. Interacts with PKP4;
the interaction is detected at the midbody. Interacts (GTP-bound form preferentially) with PKN2; the interaction
stimulates autophosphorylation and phosphorylation of PKN2. Interacts with ARHGDIA; this interaction inactivates
and stabilizes RHOA. Interacts with ARHGDIB
Selected PDB 3D structures from and Proteopedia for RHOA (see all 19):
1A2B (3D)        1CC0 (3D)        1CXZ (3D)        1DPF (3D)        1FTN (3D)        1KMQ (3D)    
Secondary accessions: P06749 Q53HM4 Q5U024 Q9UDJ0 Q9UEJ4

Explore the universe of human proteins at neXtProt for RHOA: NX_P61586

Explore proteomics data for RHOA at MOPED

Post-translational modifications: 

  • Substrate for botulinum ADP-ribosyltransferase1
  • Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment,
    and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage1
  • AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and
    V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the
    GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in
    infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but
    additional experiments remain to be done to confirm results in vivo1
  • Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling1
  • Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by
    the proteasome, thereby regulating the actin cytoskeleton and cell migration1
  • Ubiquitination2 at Lys104, Lys135
  • Modification sites at PhosphoSitePlus

  • See RHOA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001655.1  
    ENSEMBL proteins: 
     ENSP00000400175   ENSP00000394483   ENSP00000413587   ENSP00000408402   ENSP00000400747  
    Reactome Protein details: P61586

    RHOA Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for RHOA
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    Cloud-Clone Corp. Proteins for RHOA

     
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    Abcam antibodies for RHOA (P08134, P61586)
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    LSBio Antibodies in human, mouse, rat for RHOA

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOA
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    Search eBioscience for ELISAs for RHOA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P61586

    ProtoNet protein and cluster: P61586

    1 Blocks protein domain: IPB003577 Ras small GTPase

    UniProtKB/Swiss-Prot: RHOA_HUMAN, P61586
    Domain: The basic-rich region is essential for yopT recognition and cleavage
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RHOA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOA_HUMAN, P61586
    Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal
    adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin
    contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation.
    Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT
    cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes
    gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2,
    which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and
    adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in
    ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2
    to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization
    of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization
    Enzyme regulation: GTP hydrolysis is stimulated by ARHGAP30

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10436159
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IEA--
    GO:0017022myosin binding IPI15644318
    GO:0019904protein domain specific binding ----
         
    Find genes that share ontologies with RHOA           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for RHOA:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased focal adhesion (FA)  
     Decreased homologous recombina  Increased Salmonella enterica   Increased gamma-H2AX phosphory  Stronger migration 
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rhoa):
     cellular  embryogenesis  hematopoietic system  mortality/aging  nervous system 
     normal 

    Find genes that share phenotypes with RHOA           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHOA
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOA

    miRNA
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    miRTarBase miRNAs that target RHOA:
    hsa-mir-320c (MIRT036175), hsa-mir-31-5p (MIRT000088), hsa-mir-124-3p (MIRT022883), hsa-mir-200c-3p (MIRT007345), hsa-mir-185-5p (MIRT004036), hsa-mir-122-5p (MIRT000717), hsa-mir-221-3p (MIRT046885), hsa-mir-155-5p (MIRT001961), hsa-mir-146b-5p (MIRT041611), hsa-mir-31-3p (MIRT007065), hsa-mir-375 (MIRT019977)

    Block miRNA regulation of human, mouse, rat RHOA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOA (see all 14):
    hsa-miR-142-5p hsa-miR-577 hsa-miR-429 hsa-miR-548e hsa-miR-340 hsa-miR-548a-3p hsa-miR-183* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidRHOA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHOA

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RHOA (NM_001664)
    Sino Biological Human cDNA Clone for RHOA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOA
    Addgene plasmids for RHOA 

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    eBioscience FlowRNA Probe Sets ( VA1-12291 VA4-11290) for RHOA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOA_HUMAN, P61586: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow.
    Cytoplasm, cell cortex. Midbody. Cell projection, lamellipodium (By similarity). Note=Localized to cell-cell
    contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow
    formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive
    furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    mitochondrion2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005739mitochondrion ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with RHOA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOA About   (see all 107)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    3Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    4Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35


    Find genes that share SuperPaths with RHOA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for RHOA
        Wnt Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RHOA (see all 56)
        RhoA Pathway
    Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    G12-G13 in Cellular Signaling

    1 Cell Signaling Technology (CST) Pathway for RHOA
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for RHOA (see all 23)
        Cytoskeleton remodeling Role of PDGFs in cell migration
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Chemotaxis CXCR4 signaling pathway
    Development Slit-Robo signaling

    Selected BioSystems Pathways for RHOA (see all 58)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    G13 Signaling Pathway

    3 Sino Biological Pathways for RHOA
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for RHOA (see all 11)
        Axonal growth inhibition (RHOA activation)
    G alpha (12/13) signalling events
    Axonal growth stimulation
    Rho GTPase cycle
    GPVI-mediated activation cascade

    1 PharmGKB Pathway for RHOA
        Bisphosphonate Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for RHOA) (see all 26):
        Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    Endocytosis
    Vascular smooth muscle contraction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RHOA (see all 18): 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Wound Healing in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RHOA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOA (P615861, 2, 3 ENSP000004001754) via UniProtKB, MINT, STRING, and/or I2D (see all 312)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGERQ151091, 2, 3EBI-446668,EBI-1646426 MINT-7301186 MINT-7301204 I2D: score=1 
    ENSG00000206320Q151091, 2, 3EBI-446668,EBI-1646426 MINT-7301186 MINT-7301204 I2D: score=1 
    ENSG00000229058Q151091, 2, 3EBI-446668,EBI-1646426 MINT-7301186 MINT-7301204 I2D: score=1 
    ENSG00000230514Q151091, 2, 3EBI-446668,EBI-1646426 MINT-7301186 MINT-7301204 I2D: score=1 
    ENSG00000231268Q151091, 2, 3EBI-446668,EBI-1646426 MINT-7301186 MINT-7301204 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 60):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia ----
    GO:0006184GTP catabolic process TAS10436159
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0007160cell-matrix adhesion ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with RHOA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RHOA

    4 HMDB Compounds for RHOA    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    1 DrugBank Compound for RHOA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for RHOA gene (see all 107)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geranylgeranyl pyrophosphate 85.4 26 11864926 (2), 16873994 (2), 17947676 (2), 11334884 (1) (see all 16)
    mdi-a 83.6 21 12847276 (4), 12445462 (2), 17307336 (2), 18829452 (1) (see all 11)
    gdp 71.8 39 11342655 (3), 11864926 (2), 9548756 (2), 9199174 (2) (see all 25)
    fasudil 71 5 15980430 (1), 20368772 (1), 16931799 (1), 15627783 (1) (see all 5)
    actomyosin 71 21 17646397 (2), 18086913 (2), 17446864 (1), 19334011 (1) (see all 17)
    mevalonate 70.6 11 11788600 (2), 12427032 (2), 11286990 (1), 17075836 (1) (see all 8)
    gtp 70 100 10716190 (4), 18377644 (3), 12620811 (3), 16914531 (3) (see all 50)
    geranylgeraniol 69.7 6 15951198 (2), 16740276 (1), 10559211 (1), 12771933 (1) (see all 5)
    farnesyl diphosphate 65.4 8 11334884 (1), 11470741 (1), 16858009 (1), 17237547 (1) (see all 5)
    lovastatin 58.8 35 19151402 (7), 20455727 (5), 19038009 (3), 14572607 (2) (see all 15)



    Find genes that share compounds with RHOA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHOA gene: 
    NM_001664.2  

    Unigene Cluster for RHOA:

    Ras homolog family member A
    Hs.247077  [show with all ESTs]
    Unigene Representative Sequence: NM_001664
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418115(uc010hku.3 uc003cwu.3) ENST00000454011 ENST00000422781
    ENST00000445425 ENST00000431929 ENST00000265538
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RHOA (see all 14):
    hsa-miR-142-5p hsa-miR-577 hsa-miR-429 hsa-miR-548e hsa-miR-340 hsa-miR-548a-3p hsa-miR-183* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidRHOA 3' UTR sequence
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    eBioscience FlowRNA Probe Sets ( VA1-12291 VA4-11290) for RHOA 

    Additional mRNA sequence: 

    AF498970.1 AK130066.1 AK130808.1 AK222556.1 AK296654.1 AK307220.1 BC000946.3 BC001360.2 
    BC005976.1 BT019870.1 BX647063.1 L09159.1 L25080.1 X05026.1 

    Selected DOTS entries (see all 72):

    DT.91860959  DT.100695868  DT.100695864  DT.100695869  DT.120904554  DT.97868367  DT.100695874  DT.453628 
    DT.100695847  DT.91777425  DT.100059757  DT.91777469  DT.91777473  DT.91777456  DT.100695880  DT.100695892 
    DT.100849651  DT.100695881  DT.120904642  DT.100695902  DT.120904717  DT.100853328  DT.100853666  DT.91645983 

    Selected AceView cDNA sequences (see all 2393):

    BU627544 BG258331 BE906974 BQ423848 BQ233391 CR591837 AI460362 CA419636 
    CA419481 AW054949 AW328532 BM461977 CB149575 BQ431779 CA418283 AI818316 
    BE779197 BM672298 N33344 BM459241 CB153082 CR602199 AU076962 BQ959924 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RHOA    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:                    -                                 
    SP3:              -     -     -                           
    SP4:                    -     -     -                     


    ECgene alternative splicing isoforms for RHOA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGCACTC
    RHOA Expression
    About this image


    RHOA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    RHOA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247077
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RHOA (see all 18): 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Wound Healing in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHOA gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhoa1 , 5 ras homolog gene family, member A1, 5 93.78(n)1
    99.48(a)1
      9 (59.20 cM)5
    118481  NM_016802.41  NP_058082.21 
     1083062055 
    chicken
    (Gallus gallus)
    Aves RHOA1 ras homolog gene family, member A 83.77(n)
    99.48(a)
      395442  NM_204704.1  NP_990035.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    99(a)
    many ↔ many
    2(147510464-147522987)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF151015.12   -- 83.56(n)    AF151015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17g012 Danio rerio cDNA clone MGC63939 IMAGE6791145, complete more 81.37(n)    BC054576.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rho16
    Rho1
    87(a)
    1 → many
    2R(11990191-11994734)
    worm
    (Caenorhabditis elegans)
    Secernentea rho-16
    Protein RHO-1 (rho-1) mRNA, complete cds
    88(a)
    1 → many
    IV(16482851-16489021) WBGene00004357
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHO11 RHO1 63.7(n)
    72.25(a)
      856294   NP_015491.1 


    ENSEMBL Gene Tree for RHOA (if available)
    TreeFam Gene Tree for RHOA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOA gene
    RHOB2  RND12  RHOD2  RHOF2  ENSG000002718102  RHOC2  RND32  RND22  
    Selected SIMAP similar genes for RHOA using alignment to 5 protein entries:     RHOA_HUMAN (see all proteins) (see all similar genes):
    ARHA    RHOB    RHOC    SUV420H1    EIF3K    NEK4
    TP63    EEF1E1    FLJ00047    RND3    ARHE    AURA2
    PUS1    RHOQ    UTY    RHOF    RAC3    NF2

    Find genes that share paralogs with RHOA           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RHOA
    PGOHUM00000242390 PGOHUM00000243294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOA (see all 987)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573540411,2
    C--49370941(+) AAAAA-/AAAAAAAA
    /AAAAAAAAA
    GAGTT
    2 -- int1 cds11NA 2
    rs2006172341,2
    --49397900(+) AAAGA-/TTTTTT 1 -- int10--------
    rs1381052141,2
    --49397911(+) TTTTCC/TTTTTT 1 -- int10--------
    rs1927241661,2
    C--49397936(+) TCGTCA/GGTCGC 1 -- int10--------
    rs1495400491,2
    C--49397959(+) GCAATA/GGCATG 1 -- int10--------
    rs1848813641,2
    --49398220(+) GCTGTC/TAAACT 1 -- int10--------
    rs1884471281,2
    --49398448(+) TTGCAC/GTTGAG 1 -- int10--------
    rs1143008001,2
    F--49398464(+) ATCGTG/ACCACA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs3752863981,2
    C--49398505(+) TTCTC-/AAAAAA 1 -- int10--------
    rs8929741,2
    C,H--49398514(-) GTTTTT/GTTTTT 1 -- int17Minor allele frequency- G:0.07NA WA CSA 14

    HapMap Linkage Disequilibrium report for RHOA (49396578 - 49450431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RHOA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv236940CNV Loss16902084
    nsv834687CNV Loss17160897
    nsv237162CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 165390    OMIM disorders: --


    Find genes that share disorders with RHOA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RHOA gene (see all 68)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 41.1 40 20383141 (3), 17597401 (2), 19550117 (2), 12581011 (2) (see all 23)
    cancer 36.9 48 20383141 (3), 14598891 (3), 15059348 (2), 19499974 (2) (see all 35)
    tumors 32.7 131 8302578 (6), 12855641 (5), 10328216 (4), 17881360 (3) (see all 58)
    cardiac hypertrophy 22 2 15715922 (1), 17468766 (1)
    prostate cancer 21.2 12 16402387 (3), 16231705 (2), 19667069 (1), 19302267 (1) (see all 9)
    hypertension pulmonary 17.2 4 16428270 (1), 19416631 (1), 15109211 (1), 19299501 (1)
    atherosclerosis 16.6 1 12860900 (1)
    carcinoma non-small cell lung 15.9 1 17684444 (1)
    gastric cancer 15.7 53 15448013 (7), 19372585 (4), 15059348 (4), 14975755 (4) (see all 11)
    melanoma 15.7 17 18922893 (3), 19293150 (2), 12972558 (2), 12445208 (1) (see all 9)

    Genetic Association Database (GAD): RHOA
    Human Genome Epidemiology (HuGE) Navigator: RHOA (14 documents)

    Export disorders for RHOA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOA gene, integrated from 10 sources (see all 1338):
    (articles sorted by number of sources associating them with RHOA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The armadillo protein p0071 regulates Rho signalling during cytokinesis. (PubMed id 17115030)1, 2, 9 Wolf A.... Hatzfeld M. (Nat. Cell Biol. 2006)
    2. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096)1, 2, 9 Arthur W.T.... Wennerberg K. (J. Biol. Chem. 2002)
    3. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PubMed id 11696353)1, 2, 9 Klussmann E.... Rosenthal W. (FEBS Lett. 2001)
    4. RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway. (PubMed id 20499158)1, 2 Cao X.X....Liu X.P. (Breast Cancer Res. Treat. 2011)
    5. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (Hum. Immunol. 2010)
    6. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    9. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    10. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387 HGNC: 667 AceView: RHOA Ensembl:ENSG00000067560 euGenes: HUgn387
    ECgene: RHOA Kegg: 387 H-InvDB: RHOA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RHOA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RHOA gene:
    Search GeneIP for patents involving RHOA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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