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Aliases for RHNO1 Gene

Aliases for RHNO1 Gene

  • RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1 2 3
  • RHINO 3 4 6
  • RAD9, RAD1, HUS1-Interacting Nuclear Orphan Protein 3 4
  • C12orf32 3 4
  • RAD9, HUS1, RAD1-Interacting Nuclear Orphan Protein 1 3
  • Rad9, Rad1, Hus1 Interacting Nuclear Orphan 3
  • Chromosome 12 Open Reading Frame 32 2
  • Hus1 Interacting Nuclear Orphan 2
  • HKMT1188 3
  • C12orf43 6
  • RAD1 2
  • Rad9 2

External Ids for RHNO1 Gene

Previous Symbols for RHNO1 Gene

  • C12orf32

Summaries for RHNO1 Gene

GeneCards Summary for RHNO1 Gene

RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RHNO1 Gene

  • Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHNO1 Gene

Genomics for RHNO1 Gene

Genomic Location for RHNO1 Gene

Start:
2,876,258 bp from pter
End:
2,889,525 bp from pter
Size:
13,268 bases
Orientation:
Plus strand

Genomic View for RHNO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHNO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHNO1 Gene

No data available for Regulatory Elements for RHNO1 Gene

Proteins for RHNO1 Gene

  • Protein details for RHNO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSD3-RHNO1_HUMAN
    Recommended name:
    RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
    Protein Accession:
    Q9BSD3
    Secondary Accessions:
    • B7Z989

    Protein attributes for RHNO1 Gene

    Size:
    238 amino acids
    Molecular mass:
    26709 Da
    Quaternary structure:
    • Interacts with RAD9A, RAD18, TOPBP1 and UBE2N.

    Alternative splice isoforms for RHNO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHNO1 Gene

Proteomics data for RHNO1 Gene at MOPED

Post-translational modifications for RHNO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RHNO1 Gene

Domains for RHNO1 Gene

Protein Domains for RHNO1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RHNO1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RHNO1 Gene

Function for RHNO1 Gene

Molecular function for RHNO1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.
UniProtKB/Swiss-Prot Induction: Up-regulated in breast cancer cells.

Gene Ontology (GO) - Molecular Function for RHNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21659603
genes like me logo Genes that share ontologies with RHNO1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RHNO1 Gene

Localization for RHNO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHNO1 Gene

Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner.

Gene Ontology (GO) - Cellular Components for RHNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20811708
GO:0005694 chromosome IDA 21659603
genes like me logo Genes that share ontologies with RHNO1: view

No data available for Subcellular locations from COMPARTMENTS for RHNO1 Gene

Pathways for RHNO1 Gene

SuperPathways for RHNO1 Gene

No Data Available

Interacting Proteins for RHNO1 Gene

Gene Ontology (GO) - Biological Process for RHNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 21659603
GO:0000725 recombinational repair IMP 21659603
GO:0034644 cellular response to UV IDA 21659603
GO:0070318 positive regulation of G0 to G1 transition IMP 20811708
GO:0071479 cellular response to ionizing radiation IDA 21659603
genes like me logo Genes that share ontologies with RHNO1: view

No data available for Pathways by source for RHNO1 Gene

Transcripts for RHNO1 Gene

Unigene Clusters for RHNO1 Gene

RAD9-HUS1-RAD1 interacting nuclear orphan 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHNO1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b
SP1:
SP2: - - -
SP3: -

Relevant External Links for RHNO1 Gene

GeneLoc Exon Structure for
RHNO1
ECgene alternative splicing isoforms for
RHNO1

Expression for RHNO1 Gene

mRNA expression in normal human tissues for RHNO1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RHNO1 Gene

SOURCE GeneReport for Unigene cluster for RHNO1 Gene Hs.198853

mRNA Expression by UniProt/SwissProt for RHNO1 Gene

Q9BSD3-RHNO1_HUMAN
Tissue specificity: Weakly expressed in testis, prostate, ovary, thymus and small intestine. Expressed strongly in breast cancer cells.
genes like me logo Genes that share expressions with RHNO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RHNO1 Gene

Orthologs for RHNO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RHNO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHNO1 35
  • 99.86 (n)
  • 99.58 (a)
RHNO1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHNO1 35
  • 79.66 (n)
  • 71.61 (a)
RHNO1 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHNO1 35
  • 80.53 (n)
  • 70.17 (a)
RHNO1 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhno1 16
Rhno1 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHNO1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHNO1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C12ORF32 35
  • 51.53 (n)
  • 37.99 (a)
C12ORF32 36
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhno1 35
  • 48.51 (n)
  • 41.31 (a)
Species with no ortholog for RHNO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RHNO1 Gene

ENSEMBL:
Gene Tree for RHNO1 (if available)
TreeFam:
Gene Tree for RHNO1 (if available)

Paralogs for RHNO1 Gene

No data available for Paralogs for RHNO1 Gene

Variants for RHNO1 Gene

Sequence variations from dbSNP and Humsavar for RHNO1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2334870 -- 2,884,393(+) AGCTA(A/G)TTTTT intron-variant
rs2907608 -- 2,888,231(-) ACAGA(A/C/G/T)GATGA synonymous-codon, reference, nc-transcript-variant
rs2907609 -- 2,887,045(-) TTATT(C/T)ATCTT intron-variant, nc-transcript-variant
rs2907610 -- 2,887,008(-) GGTCT(C/T)GTTCT intron-variant, nc-transcript-variant
rs2907611 -- 2,884,968(-) AGTCT(A/G)GCAAA intron-variant

Relevant External Links for RHNO1 Gene

HapMap Linkage Disequilibrium report
RHNO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RHNO1 Gene

Disorders for RHNO1 Gene

No disorders were found for RHNO1 Gene.

No data available for UniProtKB/Swiss-Prot for RHNO1 Gene

Publications for RHNO1 Gene

  1. Involvement of C12orf32 overexpression in breast carcinogenesis. (PMID: 20811708) Kim J.W. … Nakamura Y. (Int. J. Oncol. 2010) 2 3 4
  2. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. (PMID: 21659603) Cotta-Ramusino C. … Elledge S.J. (Science 2011) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RHNO1 Gene

Sources for RHNO1 Gene

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