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Aliases for RHNO1 Gene

Aliases for RHNO1 Gene

  • RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1 2 3 5
  • RAD9, RAD1, HUS1-Interacting Nuclear Orphan Protein 3 4
  • C12orf32 3 4
  • RHINO 3 4
  • Rad9, Rad1, Hus1 Interacting Nuclear Orphan 3
  • Chromosome 12 Open Reading Frame 32 2
  • Hus1 Interacting Nuclear Orphan 2
  • HKMT1188 3
  • RAD1 2
  • Rad9 2

External Ids for RHNO1 Gene

Previous HGNC Symbols for RHNO1 Gene

  • C12orf32

Previous GeneCards Identifiers for RHNO1 Gene

  • GC12P002988
  • GC12P002985

Summaries for RHNO1 Gene

GeneCards Summary for RHNO1 Gene

RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1) is a Protein Coding gene. Diseases associated with RHNO1 include Cavernous Sinus Thrombosis and Sphenoid Sinusitis. Among its related pathways are Cell Cycle Checkpoints and Gene Expression.

UniProtKB/Swiss-Prot for RHNO1 Gene

  • Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHNO1 Gene

Genomics for RHNO1 Gene

Regulatory Elements for RHNO1 Gene

Enhancers for RHNO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RHNO1 on UCSC Golden Path with GeneCards custom track

Promoters for RHNO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHNO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RHNO1 Gene

Chromosome:
12
Start:
2,876,258 bp from pter
End:
2,889,525 bp from pter
Size:
13,268 bases
Orientation:
Plus strand

Genomic View for RHNO1 Gene

Genes around RHNO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHNO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHNO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHNO1 Gene

Proteins for RHNO1 Gene

  • Protein details for RHNO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSD3-RHNO1_HUMAN
    Recommended name:
    RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
    Protein Accession:
    Q9BSD3
    Secondary Accessions:
    • B7Z989

    Protein attributes for RHNO1 Gene

    Size:
    238 amino acids
    Molecular mass:
    26709 Da
    Quaternary structure:
    • Interacts with RAD9A, RAD18, TOPBP1 and UBE2N.

    Alternative splice isoforms for RHNO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHNO1 Gene

Proteomics data for RHNO1 Gene at MOPED

Post-translational modifications for RHNO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RHNO1 Gene

Domains & Families for RHNO1 Gene

Protein Domains for RHNO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RHNO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RHNO1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RHNO1 Gene

Function for RHNO1 Gene

Molecular function for RHNO1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in breast cancer cells.

Phenotypes for RHNO1 Gene

genes like me logo Genes that share phenotypes with RHNO1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RHNO1 Gene

Localization for RHNO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHNO1 Gene

Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHNO1 Gene COMPARTMENTS Subcellular localization image for RHNO1 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RHNO1 Gene

Pathways & Interactions for RHNO1 Gene

genes like me logo Genes that share pathways with RHNO1: view

Pathways by source for RHNO1 Gene

Interacting Proteins for RHNO1 Gene

Gene Ontology (GO) - Biological Process for RHNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 21659603
GO:0000725 recombinational repair IMP 21659603
GO:0006260 DNA replication TAS --
GO:0070318 positive regulation of G0 to G1 transition IMP 20811708
GO:0071479 cellular response to ionizing radiation IEA,IDA 21659603
genes like me logo Genes that share ontologies with RHNO1: view

No data available for SIGNOR curated interactions for RHNO1 Gene

Drugs & Compounds for RHNO1 Gene

No Compound Related Data Available

Transcripts for RHNO1 Gene

Unigene Clusters for RHNO1 Gene

RAD9-HUS1-RAD1 interacting nuclear orphan 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHNO1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b
SP1:
SP2: - - -
SP3: -

Relevant External Links for RHNO1 Gene

GeneLoc Exon Structure for
RHNO1
ECgene alternative splicing isoforms for
RHNO1

Expression for RHNO1 Gene

mRNA expression in normal human tissues for RHNO1 Gene

Protein differential expression in normal tissues from HIPED for RHNO1 Gene

This gene is overexpressed in Urine (35.8) and Plasma (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RHNO1 Gene



SOURCE GeneReport for Unigene cluster for RHNO1 Gene Hs.198853

mRNA Expression by UniProt/SwissProt for RHNO1 Gene

Q9BSD3-RHNO1_HUMAN
Tissue specificity: Weakly expressed in testis, prostate, ovary, thymus and small intestine. Expressed strongly in breast cancer cells.
genes like me logo Genes that share expression patterns with RHNO1: view

Protein tissue co-expression partners for RHNO1 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RHNO1 Gene

Orthologs for RHNO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RHNO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RHNO1 35
  • 79.66 (n)
  • 71.61 (a)
RHNO1 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHNO1 35
  • 80.53 (n)
  • 70.17 (a)
RHNO1 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RHNO1 35
  • 99.86 (n)
  • 99.58 (a)
RHNO1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHNO1 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhno1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHNO1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C12ORF32 35
  • 51.53 (n)
  • 37.99 (a)
C12ORF32 36
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhno1 35
  • 48.51 (n)
  • 41.31 (a)
Species with no ortholog for RHNO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RHNO1 Gene

ENSEMBL:
Gene Tree for RHNO1 (if available)
TreeFam:
Gene Tree for RHNO1 (if available)

Paralogs for RHNO1 Gene

No data available for Paralogs for RHNO1 Gene

Variants for RHNO1 Gene

Sequence variations from dbSNP and Humsavar for RHNO1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7133567 -- 2,883,908(+) GAGCT(A/G)GATAA intron-variant
rs7134175 -- 2,883,717(+) CTCCA(C/T)GTTGG intron-variant
rs7134309 -- 2,883,805(+) GCCAC(C/T)GCGCC intron-variant
rs7134422 -- 2,883,891(+) CTAGC(C/T)GACAG intron-variant
rs7296866 -- 2,885,777(+) TCACC(A/G)TGTTA intron-variant

Variation tolerance for RHNO1 Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHNO1 Gene

Human Gene Mutation Database (HGMD)
RHNO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RHNO1 Gene

Disorders for RHNO1 Gene

MalaCards: The human disease database

(43) MalaCards diseases for RHNO1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cavernous sinus thrombosis
  • thrombosis of cavernous venous sinus
sphenoid sinusitis
  • sphenoidal sinusitis
acute orbital inflammation
  • acute inflammation of orbit
orbital cellulitis
rhinoscleroma
- elite association - COSMIC cancer census association via MalaCards
Search RHNO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHNO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHNO1
genes like me logo Genes that share disorders with RHNO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHNO1 Gene

Publications for RHNO1 Gene

  1. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. (PMID: 21659603) Cotta-Ramusino C. … Elledge S.J. (Science 2011) 2 3 4 67
  2. Involvement of C12orf32 overexpression in breast carcinogenesis. (PMID: 20811708) Kim J.W. … Nakamura Y. (Int. J. Oncol. 2010) 2 3
  3. RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling. (PMID: 25602520) Lindsey-Boltz L.A. … Sancar A. (Cell Cycle 2015) 3
  4. Evaluation of the RHINO gene for breast cancer predisposition in Finnish breast cancer families. (PMID: 24562772) Heikkinen T. … Nevanlinna H. (Breast Cancer Res. Treat. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RHNO1 Gene

Sources for RHNO1 Gene

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