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Aliases for RHEBL1 Gene

Aliases for RHEBL1 Gene

  • Ras Homolog Enriched In Brain Like 1 2 3
  • Ras Homolog Enriched In Brain-Like Protein 1 3 4
  • Ras Homolog Enriched In Brain Like-1 C 3 4
  • Rheb-Like Protein 1 3 4
  • RHEBL1c 3 4
  • RHEB2 3 4
  • Ras Homolog Enriched In Brain Like 1 C 3
  • GTPase RhebL1 3

External Ids for RHEBL1 Gene

Summaries for RHEBL1 Gene

GeneCards Summary for RHEBL1 Gene

RHEBL1 (Ras Homolog Enriched In Brain Like 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot for RHEBL1 Gene

  • Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHEBL1 Gene

Genomics for RHEBL1 Gene

Genomic Location for RHEBL1 Gene

Start:
49,064,684 bp from pter
End:
49,070,025 bp from pter
Size:
5,342 bases
Orientation:
Minus strand

Genomic View for RHEBL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHEBL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHEBL1 Gene

Regulatory Elements for RHEBL1 Gene

Proteins for RHEBL1 Gene

  • Protein details for RHEBL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAI7-REBL1_HUMAN
    Recommended name:
    GTPase RhebL1
    Protein Accession:
    Q8TAI7
    Secondary Accessions:
    • Q56VH8

    Protein attributes for RHEBL1 Gene

    Size:
    183 amino acids
    Molecular mass:
    20682 Da
    Quaternary structure:
    • Interacts with MTOR.
    SequenceCaution:
    • Sequence=AAS80166.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RHEBL1 Gene

    Alternative splice isoforms for RHEBL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHEBL1 Gene

Proteomics data for RHEBL1 Gene at MOPED

Post-translational modifications for RHEBL1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys162

Other Protein References for RHEBL1 Gene

No data available for DME Specific Peptides for RHEBL1 Gene

Domains for RHEBL1 Gene

UniProtKB/Swiss-Prot:

REBL1_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rheb family.:
    • Q8TAI7
genes like me logo Genes that share domains with RHEBL1: view

No data available for Gene Families for RHEBL1 Gene

Function for RHEBL1 Gene

Molecular function for RHEBL1 Gene

UniProtKB/Swiss-Prot Function: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.

Gene Ontology (GO) - Molecular Function for RHEBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IDA 12869548
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RHEBL1: view

Phenotypes for RHEBL1 Gene

genes like me logo Genes that share phenotypes with RHEBL1: view

Animal Models for RHEBL1 Gene

MGI Knock Outs for RHEBL1:

miRNA for RHEBL1 Gene

miRTarBase miRNAs that target RHEBL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RHEBL1 Gene

Localization for RHEBL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHEBL1 Gene

Endomembrane system; Lipid-anchor; Cytoplasmic side. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHEBL1 Gene COMPARTMENTS Subcellular localization image for RHEBL1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHEBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 16328882
GO:0005886 plasma membrane --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RHEBL1: view

Pathways for RHEBL1 Gene

SuperPathways for RHEBL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RHEBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
GO:0031929 TOR signaling IMP 12869548
genes like me logo Genes that share ontologies with RHEBL1: view

No data available for Pathways by source for RHEBL1 Gene

Compounds for RHEBL1 Gene

(1) HMDB Compounds for RHEBL1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RHEBL1: view

Transcripts for RHEBL1 Gene

mRNA/cDNA for RHEBL1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHEBL1 Gene

Ras homolog enriched in brain like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHEBL1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -

Relevant External Links for RHEBL1 Gene

GeneLoc Exon Structure for
RHEBL1
ECgene alternative splicing isoforms for
RHEBL1

Expression for RHEBL1 Gene

mRNA expression in normal human tissues for RHEBL1 Gene

mRNA differential expression in normal tissues according to GTEx for RHEBL1 Gene

This gene is overexpressed in Brain - Cortex (4.8) and Brain - Frontal Cortex (BA9) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RHEBL1 Gene

SOURCE GeneReport for Unigene cluster for RHEBL1 Gene Hs.159013

mRNA Expression by UniProt/SwissProt for RHEBL1 Gene

Q8TAI7-REBL1_HUMAN
Tissue specificity: Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines.
genes like me logo Genes that share expressions with RHEBL1: view

Orthologs for RHEBL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHEBL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHEBL1 36
  • 99.27 (n)
  • 99.45 (a)
RHEBL1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHEBL1 36
  • 90.06 (n)
  • 91.71 (a)
RHEBL1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHEBL1 36
  • 91.99 (n)
  • 96.17 (a)
RHEBL1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhebl1 36
  • 88.71 (n)
  • 88.52 (a)
Rhebl1 16
Rhebl1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHEBL1 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhebl1 36
  • 89.07 (n)
  • 86.89 (a)
lizard
(Anolis carolinensis)
Reptilia RHEBL1 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhebl1 36
  • 59.74 (n)
  • 55.19 (a)
zebrafish
(Danio rerio)
Actinopterygii rhebl1 37
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rheb 37
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rheb-1 37
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 37
  • 35 (a)
OneToMany
Species with no ortholog for RHEBL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHEBL1 Gene

ENSEMBL:
Gene Tree for RHEBL1 (if available)
TreeFam:
Gene Tree for RHEBL1 (if available)

Paralogs for RHEBL1 Gene

Paralogs for RHEBL1 Gene

Pseudogenes.org Pseudogenes for RHEBL1 Gene

genes like me logo Genes that share paralogs with RHEBL1: view

Variants for RHEBL1 Gene

Sequence variations from dbSNP and Humsavar for RHEBL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4018209 -- 49,067,286(+) ttttt(G/T)gagat intron-variant
rs5798088 -- 49,069,497(-) AATCT(-/CA)GAGTG intron-variant
rs7969091 -- 49,070,666(+) TGTAG(A/G)AGATG upstream-variant-2KB
rs10715716 -- 49,067,100(+) CTGAC(-/T)TTTTT intron-variant
rs11168840 -- 49,064,509(+) aaaat(A/T)aaaaa downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RHEBL1 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897
nsv819798 CNV Loss 19587683

Relevant External Links for RHEBL1 Gene

HapMap Linkage Disequilibrium report
RHEBL1

Disorders for RHEBL1 Gene

(2) University of Copenhagen DISEASES for RHEBL1 Gene

genes like me logo Genes that share disorders with RHEBL1: view

No data available for UniProtKB/Swiss-Prot for RHEBL1 Gene

Publications for RHEBL1 Gene

  1. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. (PMID: 16098514) Tee A.R. … Proud C.G. (FEBS Lett. 2005) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. (PMID: 12869548) Tabancay A.P. Jr. … Tamanoi F. (J. Biol. Chem. 2003) 3 4
  4. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. (PMID: 16328882) Yuan J. … Yu L. (Mol. Biol. Rep. 2005) 3 4
  5. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. (PMID: 20368287) Pilot-Storck F. … Goillot E. (Mol. Cell Proteomics 2010) 3

Products for RHEBL1 Gene

Sources for RHEBL1 Gene

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