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RHEBL1 Gene

protein-coding   GIFtS: 50
GCID: GC12M049458

Ras Homolog Enriched In Brain Like 1

  Search for RHEBL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Enriched In Brain Like 11 2     GTPase RhebL12
Ras Homolog Enriched In Brain Like-1 C2 3     Ras Homolog Enriched In Brain Like 1 C2
Ras Homolog Enriched In Brain-Like Protein 12 3     rheb22
Rheb-Like Protein 12 3     Rheb23
RHEBL1c2     RhebL1c3

External Ids:    HGNC: 211661   Entrez Gene: 1212682   Ensembl: ENSG000001675507   UniProtKB: Q8TAI73   

Export aliases for RHEBL1 gene to outside databases

Previous GC identifers: GC12M049175 GC12M047744 GC12M046490


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHEBL1 Gene:
RHEBL1 (Ras homolog enriched in brain like 1) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot: REBL1_HUMAN, Q8TAI7
Function: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription.
Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small
GTPase-activating proteins TSC1 and TSC2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHEBL1 gene promoter:
         POU3F1   XBP-1   Roaz   PPAR-gamma1   E2F   E2F-1   FOXO1a   STAT3   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHEBL1 promoter sequence
   Search Chromatin IP Primers for RHEBL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHEBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

RHEBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHEBL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049458:  view genomic region     (about GC identifiers)

Start:
49,458,468 bp from pter      End:
49,463,808 bp from pter
Size:
5,341 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: REBL1_HUMAN, Q8TAI7 (See protein sequence)
Recommended Name: GTPase RhebL1 precursor  
Size: 183 amino acids; 20682 Da
Subunit: Interacts with MTOR
Sequence caution: Sequence=AAS80166.1; Type=Erroneous translation; Note=Wrong choice of CDS;
1 PDB 3D structure from and Proteopedia for RHEBL1:
3OES (3D)    
Secondary accessions: Q56VH8
Alternative splicing: 2 isoforms:  Q8TAI7-1   Q8TAI7-2   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RHEBL1: NX_Q8TAI7

Explore proteomics data for RHEBL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys162
  • Modification sites at PhosphoSitePlus

  • See RHEBL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653194.1  
    ENSEMBL proteins: 
     ENSP00000301068   ENSP00000409818   ENSP00000446726   ENSP00000447428  

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    Cloud-Clone Corp. Proteins for RHEBL1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q8TAI7

    ProtoNet protein and cluster: Q8TAI7

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: REBL1_HUMAN, Q8TAI7
    Similarity: Belongs to the small GTPase superfamily. Rheb family


    Find genes that share domains with RHEBL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REBL1_HUMAN, Q8TAI7
    Function: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription.
    Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small
    GTPase-activating proteins TSC1 and TSC2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IDA12869548
         
    Find genes that share ontologies with RHEBL1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rhebl1):
     mortality/aging  no phenotypic analysis  normal 

    Find genes that share phenotypes with RHEBL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rhebl1tm1.1Pfw for RHEBL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHEBL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHEBL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHEBL1

    miRNA
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    miRTarBase miRNAs that target RHEBL1:
    hsa-mir-93-5p (MIRT028092), hsa-mir-19b-3p (MIRT031268)

    Block miRNA regulation of human, mouse, rat RHEBL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHEBL1 (see all 11):
    hsa-miR-30c hsa-miR-448 hsa-miR-502-5p hsa-miR-30d hsa-miR-544b hsa-miR-30a hsa-miR-19b hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidRHEBL1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for RHEBL1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REBL1_HUMAN, Q8TAI7: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA16328882
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with RHEBL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHEBL1
    Interactions:

        Search GeneGlobe Interaction Network for RHEBL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for RHEBL1 (Q8TAI72, 3 ENSP000003010684) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTORP423452, 3, ENSP000003545584MINT-62561 I2D: score=3 STRING: ENSP00000354558
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
    TXNL4AP838763, ENSP000002696014I2D: score=3 STRING: ENSP00000269601
    EIF4EBP1Q135413, ENSP000003406914I2D: score=1 STRING: ENSP00000340691
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----
    GO:0031929TOR signaling IMP12869548

    Find genes that share ontologies with RHEBL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHEBL1 (REBL1)

    1 HMDB Compound for RHEBL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHEBL1 gene: 
    NM_144593.1  

    Unigene Cluster for RHEBL1:

    Ras homolog enriched in brain like 1
    Hs.159013  [show with all ESTs]
    Unigene Representative Sequence: AY509932
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301068(uc001rtc.1 uc009zlc.1) ENST00000420065 ENST00000550797(uc001rtd.1)
    ENST00000550675
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RHEBL1 (see all 11):
    hsa-miR-30c hsa-miR-448 hsa-miR-502-5p hsa-miR-30d hsa-miR-544b hsa-miR-30a hsa-miR-19b hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidRHEBL1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RHEBL1
      QuantiFast Probe-based Assays in human, mouse, rat RHEBL1

    Additional mRNA sequence: 

    AK098663.1 AY327412.1 AY509932.1 BC014155.2 BC027482.1 

    6 DOTS entries:

    DT.75114459  DT.100021568  DT.101980850  DT.101980851  DT.102826806  DT.92017333 

    6 AceView cDNA sequences:

    NM_144593 AY327412 BC014155 CR612990 BC027482 AK098663 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RHEBL1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                  
    SP2:              -                                                   
    SP3:              -           -                                       


    ECgene alternative splicing isoforms for RHEBL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHEBL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACTGGCC
    RHEBL1 Expression
    About this image

    RHEBL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHEBL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159013

    UniProtKB/Swiss-Prot: REBL1_HUMAN, Q8TAI7
    Tissue specificity: Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHEBL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhebl11 , 5 Ras homolog enriched in brain like 11, 5 88.71(n)1
    88.52(a)1
      15 (54.99 cM)5
    691591  NM_026967.41  NP_081243.11 
     988777785 
    lizard
    (Anolis carolinensis)
    Reptilia RHEBL16
    Ras homolog enriched in brain like 1
    73(a)
    1 ↔ 1
    GL343198.1(2745085-2759314)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rhebl11 Ras homolog enriched in brain like 1 59.74(n)
    55.19(a)
      394534  NM_203606.2  NP_988937.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rhebl16
    Ras homolog enriched in brain like 1
    55(a)
    many ↔ many
    6(23368320-23379486) ENSDARG00000039162
    fruit fly
    (Drosophila melanogaster)
    Insecta Rheb6
    Rheb
    49(a)
    1 → many
    3R(1394618-1396213)
    worm
    (Caenorhabditis elegans)
    Secernentea rheb-16
    Protein RHEB-1 (rheb-1) mRNA, complete cds
    32(a)
    1 → many
    III(9454344-9456032) WBGene00010038
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHB16
    Putative Rheb-related GTPase involved in regulatin...
    35(a)
    1 → many
    III(167370-167999) YCR027C


    ENSEMBL Gene Tree for RHEBL1 (if available)
    TreeFam Gene Tree for RHEBL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHEBL1 gene
    RASL122  RASL11A2  RERGL2  RHEB2  RASL11B2  RERG2  
    Selected SIMAP similar genes for RHEBL1 using alignment to 4 protein entries:     REBL1_HUMAN (see all proteins) (see all similar genes):
    RHEB    DIRAS2    HRAS    RAP1B    KRAS    NRAS
    RAP2A    DKFZp547A0616    RALA    RAP2B    RAP2C    DIRAS1
    RAP1A    c-bas/has    RIT2    RAB13    RAB21    RAB30

    Find genes that share paralogs with RHEBL1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RHEBL1
    PGOHUM00000261096 PGOHUM00000263248


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHEBL1 (see all 131)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923166261,2
    --49458116(+) AAAAAA/GAGATC 1 -- int10--------
    rs111688411,2
    --49458377(+) tgcagC/Tgagcc 1 -- int10--------
    rs1403780751,2
    --49458449(+) CACACA/GAAAAA 1 -- int10--------
    rs1445152521,2
    C--49458601(+) TAATG-/CCCAGG 1 -- ut310--------
    rs1837095121,2
    --49458755(+) AGGATA/GCCACA 1 -- ut310--------
    rs1880252031,2
    --49458772(+) GTCCAA/GGGGCC 1 -- ut310--------
    rs1997614631,2
    --49458848(+) GTGCCA/GGGGGC 1 -- ut310--------
    rs2014965961,2
    C--49459167(+) ATGTCG/ACACCC 2 /A /V mis11Minor allele frequency- A:0.00EU 1323
    rs1152574331,2
    F--49459394(+) CAACAC/TAGGGA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1807523851,2
    C--49459425(+) AAAAAA/TGGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for RHEBL1 (49458468 - 49463808 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RHEBL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819798CNV Loss19587683
    nsv832404CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHEBL1
    DNA2.0 Custom Variant and Variant Library Synthesis for RHEBL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases from the University of Copenhagen DISEASES database for RHEBL1:
    Renal clear cell carcinoma     Lymphangioleiomyomatosis

    Find genes that share disorders with RHEBL1           About GenesLikeMe


    Export disorders for RHEBL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHEBL1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with RHEBL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. (PubMed id 16098514)1, 2, 9 Tee A.R.... Proud C.G. (FEBS Lett. 2005)
    2. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. (PubMed id 16328882)1, 2 Yuan J.... Yu L. (Mol. Biol. Rep. 2005)
    3. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. (PubMed id 12869548)1, 2 Tabancay A.P. Jr.... Tamanoi F. (J. Biol. Chem. 2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Effects of RhebL1 silencing on the mTOR pathway. (PubMed id 21655954)1 Bonneau A. and Parmar N. (Mol. Biol. Rep. 2012)
    7. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. (PubMed id 20368287)1 Pilot-Storck F....Goillot E. (amp 2010)
    8. Activation of the mTOR signaling pathway in renal clear cell carcinoma. (PubMed id 17162089)2 Robb V.A.... Henske E.P. (J. Urol. 2007)
    9. The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. (PubMed id 16006564)2 Basso A.D.... Kirschmeier P. (J. Biol. Chem. 2005)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121268 HGNC: 21166 AceView: RHEBL1 Ensembl:ENSG00000167550 euGenes: HUgn121268
    ECgene: RHEBL1 H-InvDB: RHEBL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHEBL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHEBL1 gene:
    Search GeneIP for patents involving RHEBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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