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RHEB Gene

protein-coding GIFtS: 63

GC07M150794

Ras homolog enriched in brain
(Previous name: Ras homolog enriched in brain 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RHEB2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC111559 ^²
RHEB2 ^², ³

Descriptions
GTP-binding protein Rheb ^²
Ras homolog enriched in brain ^², ³
Ras homolog enriched in brain 2 ^¹, ²

External Ids
HGNC: 10011¹
Entrez Gene: 6009²
UniProtKB: Q15382³
Ensembl: ENSG00000106615⁷

Search outside databases for aliases for RHEB gene

Previous GC identifers: GC07M150478 GC07M150555 GC07M150554 GC07M150600

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RHEB:

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane

protein with five repeats of the RAS-related GTP-binding region. This protein is vital in

regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling

pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound

form, and farnesylation of the protein is required for this activity. Three pseudogenes have been

mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq]

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382

Function: Not known; binds GTP and exhibits intrinsic GTPase activity (By similarity)

Gene Wiki entry for RHEB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RHEB gene

Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36

RHEB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M150794: (about GC identifiers)

Start:	150,794,031 bp from pter
End:	150,847,943 bp from pter
Size:	53,913 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 150,492,679-150,546,598

RefSeq DNA sequence:

NC_000007.12 NT_007914.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382 (See protein sequence)

Recommended Name: GTP-binding protein Rheb precursor

Size: 184 amino acids; 20497 Da

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

PDB structures from and Proteopedia :

1XTQ (3D)

1XTR (3D)

1XTS (3D)

Secondary accessions: B3KWN6 Q53Y56 Q99444

REFSEQ proteins: NP_005605.1

ENSEMBL proteins:

ENSP00000262187

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RHEB)
	Human Recombinant Proteins from Abnova (RHEB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005681	spliceosome	IEA	--
GO:0005829	cytosol	EXP	15755954 15809305 15951850
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for RHEB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RHEB
	R&D Systems Antibodies for RHEB
	Cell Signaling Technology (CST) Antibodies for RHEB
	Antibodies from Abcam (RHEB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RHEB)
	Novus Biologicals Antibodies for RHEB

Assays for RHEB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15382

ProtoNet protein and cluster: Q15382

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382

Similarity: Belongs to the small GTPase superfamily. Rheb family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RHEB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHEB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005614

Applied Biosystems Silencer® siRNAs for RHEB

Sigma-Aldrich siRNA for RHEB

Sigma-Aldrich shRNA for RHEB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RHEB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005614
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005614
untagged cDNA clone in CMV expression vector: NM_005614

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005614

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382

Function: Not known; binds GTP and exhibits intrinsic GTPase activity (By similarity)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	8206940
GO:0005525	GTP binding	TAS	8543055

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for RHEB (Your Favorite Gene powered by Ingenuity)

PI3K/AKT Signaling

GeneDecks RHEB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RHEB

5/33 Interacting proteins for RHEB (ENSP00000262187³ Q15382²) via UniProtKB, MINT, and/or STRING (see all 33 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAF1	P04049²	STRING (score=.994) MINT-6946500
MTOR	P42345²	MINT-62559 MINT-62560
TSC2	ENSP00000219476³	STRING (score=.999)
TSC1	ENSP00000298552³	STRING (score=.997)
KIAA1303	ENSP00000307272³	STRING (score=.995)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8661031
GO:0007264	small GTPase mediated signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RHEB
3 Novoseek chemical compound relationships for RHEB gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	65.20	24	15878852 (2), 15240005 (2), 8206940 (2), 19176517 (2) (see all 12)
phosphoinositide	39.55	1	17346240 (1)
glucose	0.00	1	17371599 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RHEB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHEB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005614

Sigma-Aldrich siRNA for RHEB

Sigma-Aldrich shRNA for RHEB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005614

REFSEQ mRNAs for RHEB gene:

NM_005614.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005614

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005614
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005614
                                 untagged cDNA clone in CMV expression vector: NM_005614

Additional cDNA sequence:

AF493921.1 AK123729.1 AK125446.1 AK289370.1 BC009638.1 BC016155.1 BC066307.1 BC107705.1

BT006958.1 Z29677.1

24/41 DOTS entries (see all 41 ):

DT.97855835 DT.100732507 DT.120600 DT.121289032 DT.121288941 DT.121288834 DT.91780778 DT.91963277

DT.121103402 DT.91780762 DT.91780789 DT.91780767 DT.302945 DT.86855463 DT.121295385 DT.40274154

DT.95372211 DT.100850622 DT.121295363 DT.96085226 DT.100879690 DT.121103410 DT.121103459 DT.121103479

24/612 AceView cDNA sequences (see all 612 ):

AI393220 AI299436 AI990901 BM664243 BF057705 AI651417 Z41654 CB137085

BM720076 AI769193 BM711120 BM773404 AW000992 BM843228 N76110 W76445

BM452876 CB139929 BQ775308 AA456467 AA938332 BM670621 BU686150 CR613801

highest scoring ESTs for RHEB:

AI192108 D78132 AI393220 AA017522 AA056087 AA056145 AA059390 AA079894 AA150940 AA206771

Unigene Clusters for RHEB:

Ras homolog enriched in brain

Hs.283521 [show with all ESTs], Hs.647068 [show with all ESTs]

Unigene Representative Sequences: AK294120, NM_005614

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000262187

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RHEB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RHEB

¹ / ² / ³

17 probe-sets matching RHEB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56845_at²^{, 3}	U95-B	1	1.00	1.00	0.27	0.84	AA056145	0.80	1.00	0.91	1
78322_r_at²^{, 3}	U95-E	1	1.00	1.00	0.85	0.92	AI393220	1.00	0.87	0.94	1
40627_at²^{, 3}	U95-A	1	1.00	1.00	0.44	0.85	AI192108	1.00	1.00	1.00	1
1659_s_at²^{, 3}	U95-A	4	1.00	0.69	0.77	1.41	D78132	1.00	0.90	0.95	1
213409_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF593727	0.80	1.00	0.91	1
227633_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA056145	0.80	1.00	0.91	1
201452_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW138374	0.60	0.58	0.59	1
213404_s_at²	U133-A	3	1.00	0.71	--	--	--	--	--	--	--
201453_x_at²^{, 3}	U133-A	4	1.00	0.67	--	--	NM_005614	0.60	1.00	0.82	1
201451_x_at²^{, 3}	U133-A	1	0.55	1.00	--	--	D78132	1.00	0.90	0.95	1
213409_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227633_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201452_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213404_s_at²	U133Plus2	3	1.00	0.71	--	--	--	--	--	--	--
201453_x_at²	U133Plus2	4	1.00	0.67	--	--	--	--	--	--	--
1555780_a_at²	U133Plus2	4	1.00	0.33	--	--	--	--	--	--	--
201451_x_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

GeneDecks RHEB for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCGGTGATG

SOURCE GeneReport for Unigene clusters: Hs.283521 Hs.647068
Expression variation in blood from EXPOLDB for RHEB
UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382
Tissue specificity: Ubiquitous. Highest levels observed in skeletal and cardiac muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RHEB gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RHEB¹	--	Ras homolog enriched in brain	94.93(n) 99.46(a)	475545 XM_532768.2 XP_532768.1
chimpanzee (Pan troglodytes)	RHEB¹	--	Ras homolog enriched in brain	99.82(n) 100(a)	463880 XM_519513.2 XP_519513.1
cow (Bos taurus)	RHEB¹	--	Ras homolog enriched in brain	94.38(n) 98.91(a)	528204 NM_001031764.1 NP_001026934.1
mouse (Mus musculus)	Rheb^{1, 5}	5⁵	Ras homolog enriched in brain⁵ RAS-homolog enriched in brain¹	92.57(n)¹ 98.91(a)¹	19744¹ NM_053075.3¹ NP_444305.2¹ AB039919⁵ AK151213⁵ (see all 8)
chicken (Gallus gallus)	RHEB¹	--	Ras homolog enriched in brain	88.22(n) 97.83(a)	420434 XM_418539.2 XP_418539.1

About this table Species with no ortholog for RHEB

ENSEMBL Gene Tree for RHEB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RHEB gene

DIRAS1² DIRAS2² RHEBL1² DIRAS3²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/258 NCBI SNPs in RHEB are shown (see all 258 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 72)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6973428^1,2	A,C,F,H	150793886(+)	`CAGAGC/TGAGAC`	1	--	ng5¹		1		EU	120
	rs3807389^1,2	F,H	150848358(+)	`TTGAGC/GTGCGT`	1	--	ng3¹		5		EA EU WA	1520
--	rs9768956^1,2	A,H	150795122(+)	`TCCTCG/AGGCTT`	1	--	ut3¹ ese³		4		EU EA WA	410
	rs10227414^1,2	F,H	150793545(+)	`ATGCTC/TCCTCC`	1	--	ng5¹		4		EU EA WA	420
--	rs12537828^1,2	C	150848533(+)	`TCGGCA/GCACCT`	1	--	ng3¹		0	--	--	--	--
	rs2074997^1,2	A,C,F,H,O	150805219(-)	`TTCTCG/TTGGAG`	1	--	int¹		8		EA EU WA NA	2052
--	rs758666^1,2	A,C,F,H,O	150839263(-)	`AATAAC/TTACCT`	1	--	int¹		9		EA EU WA NA MN	2228
	rs2299965^1,2	A,C,F,H,O	150823595(+)	`GATTAC/TTGCAA`	1	--	int¹		13		EA EU WA NA	2528
	rs1109089^1,2	A,C,F,H,O	150800952(-)	`CATGCG/AGAGGA`	1	--	int¹		10		MN EU EA WA NA	916
	rs7805967^1,2	A,C,F,H	150803014(+)	`TTACTG/AAGGTA`	1	--	int¹		12		EU EA WA NA	1054

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HapMap Linkage Disequilibrium images for RHEB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601293

5 Novoseek disease relationships for RHEB gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tuberous sclerosis	89.38	19	12906785 (1), 19262129 (1), 16627617 (1), 17371599 (1) (see all 13)
tumors	18.82	11	18787409 (2), 16006564 (1), 18708578 (1), 16636147 (1) (see all 5)
genetic disorder	13.87	1	15240005 (1)
cancer	9.29	4	18787409 (2)
insulin resistance	0.00	1	15380067 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/93 PubMed articles for RHEB gene (see all 93 ):

Isolation of cDNA and genomic clones of a human Ras-related GTP- binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36. (PubMed id 8661031)^{2, 3, 4} Mizuki N.... Inoko H. (1996)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PubMed id 15308774)^{3, 4} Kho Y.... Zhao Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb. (PubMed id 8543055)^{3, 4} Gromov P.S.... Celis J.E. (1995)
The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1. (PubMed id 17470430)^{1, 3} Long X....Avruch J. (2007)
The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. (PubMed id 16006564)^{1, 3} Basso A.D.... Kirschmeier P. (2005)
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. (PubMed id 12906785)^{1, 3} Tee A.R....Blenis J. (2003)
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. (PubMed id 9099708)^{1, 3} Clark G.J....Der C.J. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6009	HGNC: 10011	AceView: RHEB	Ensembl:ENSG00000106615	euGenes: HUgn6009
ECgene: RHEB	H-InvDB: RHEB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RHEB	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RHEB
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for RHEB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RHEB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RHEB		Antibodies for RHEB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RHEB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RHEB)
	Antibodies (RHEB)
	Chimera RNAi (RHEB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RHEB

	Recombinant Proteins (RHEB)
	Antibodies (RHEB)

Search OriGene for RHEB

Search Tocris compounds for RHEB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RHEB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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RHEB Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for RHEB

Summaries
for RHEB

Genomic Location
for RHEB

Proteins
for RHEB

Protein Domains/
Families
for RHEB

Gene Function
for RHEB

Pathways & Interactions
for RHEB

Drugs & Compounds
for RHEB

Transcripts
for RHEB

Expression
for RHEB

Orthologs
for RHEB

Paralogs
for RHEB

SNPs/Variants
for RHEB

Disorders & Mutations
for RHEB

Medical News
for RHEB

Publications
for RHEB

Search for RHEB

Genome Databases showing RHEB

Other Databases showing RHEB

Specialized Databases showing RHEB

Licensable Technologies
for RHEB

Services
for RHEB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RHEB Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor RHEB

Summariesfor RHEB

Genomic Locationfor RHEB

Proteinsfor RHEB

Protein Domains/Familiesfor RHEB

Gene Functionfor RHEB

Pathways & Interactionsfor RHEB

Drugs & Compoundsfor RHEB

Transcriptsfor RHEB

Expression for RHEB

Orthologsfor RHEB

Paralogsfor RHEB

SNPs/Variantsfor RHEB

Disorders & Mutationsfor RHEB

Medical Newsfor RHEB

Publicationsfor RHEB

Search for RHEB

Genome Databases showing RHEB

Other Databases showing RHEB

Specialized Databases showing RHEB

Licensable Technologiesfor RHEB

Servicesfor RHEB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RHEB

Summaries
for RHEB

Genomic Location
for RHEB

Proteins
for RHEB

Protein Domains/
Families
for RHEB

Gene Function
for RHEB

Pathways & Interactions
for RHEB

Drugs & Compounds
for RHEB

Transcripts
for RHEB

Expression
for RHEB

Orthologs
for RHEB

Paralogs
for RHEB

SNPs/Variants
for RHEB

Disorders & Mutations
for RHEB

Medical News
for RHEB

Publications
for RHEB

Licensable Technologies
for RHEB

Services
for RHEB