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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RHEB Gene

protein-coding GIFtS: 69
GCID: GC07M151163

Ras homolog enriched in brain

(Previous name: Ras homolog enriched in brain 2 )
(Previous symbol: RHEB2)

Explore 17 diseases affiliated with
RHEB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ras Homolog Enriched In Brain¹ ² ³
RHEB2¹ ² ³ ⁵
Ras Homolog Enriched In Brain 2¹ ²
GTP-Binding Protein Rheb²

External Ids:	HGNC: 10011¹	Entrez Gene: 6009²	Ensembl: ENSG00000106615⁷	OMIM: 601293⁵	UniProtKB: Q15382³

Export aliases for RHEB gene to outside databases

Previous GC identifers: GC07M150478 GC07M150555 GC07M150554 GC07M150600 GC07M150794 GC07M144974

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHEB:

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five

repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle

progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles

between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three

pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382

Function: Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the

protein kinase activity of mTORC1. Has low intrinsic GTPase activity

Gene Wiki entry for RHEB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHEB gene promoter:
Elk-1 p53 GATA-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHEB promoter sequence

Search SABiosciences Chromatin IP Primers for RHEB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHEB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36

RHEB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHEB gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M151163: view genomic region (about GC identifiers)

Start:	151,163,098 bp from pter	End:	151,217,206 bp from pter
Size:	54,109 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 150,492,679-150,546,598

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382 (See protein sequence)

Recommended Name: GTP-binding protein Rheb precursor

Size: 184 amino acids; 20497 Da

Subunit: Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR.

Interacts with TSC2

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

Miscellaneous: The conserved catalytic Gln-64 found in other Ras-like GTPases seems not to be involved in GTP

hydrolysis in RHEB

5 PDB 3D structures from and Proteopedia for RHEB:

1XTQ (3D)

1XTR (3D)

1XTS (3D)

3SEA (3D)

3T5G (3D)

Secondary accessions: B3KWN6 D3DX13 Q53Y56 Q99444

Explore the universe of human proteins at neXtProt for RHEB: NX_Q15382

Post-translational modifications:

Farnesylation is important for efficiently activating mTORC1-mediated signaling¹

Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15382

RHEB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005605.1

ENSEMBL proteins:

ENSP00000262187 ENSP00000420726 ENSP00000417802 ENSP00000418161 ENSP00000417212

Reactome Protein details: Q15382
Human Recombinant Protein Products for RHEB:

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	ProSpec Recombinant Protein for RHEB
	Uscn Proteins for RHEB

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005681	spliceosomal complex	IEA	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	TAS	8206940
GO:0030425	dendrite	IEA	--

RHEB for ontologies About GeneDecksing

RHEB Antibody Products:

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Assay Products for RHEB:

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	Uscn ELISAs and CLIAs for RHEB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RHEB for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry Q15382

ProtoNet protein and cluster: Q15382

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382

Similarity: Belongs to the small GTPase superfamily. Rheb family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RHEB_HUMAN, Q15382

Function: Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the

protein kinase activity of mTORC1. Has low intrinsic GTPase activity

Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by

TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005525	GTP binding	ISS	--
GO:0019003	GDP binding	IEA	--
GO:0019901	protein kinase binding	IEA	--
GO:0046872	metal ion binding	IEA	--

RHEB for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rheb):

cardiovascular system	cellular	embryogenesis	growth/size	homeostasis/metabolism
immune system	mortality/aging	nervous system

RHEB for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for RHEB: Rheb^tm1.1Pfw Rheb^tm1.1Yelg

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RHEB

miRNA Products:		miRTarBase miRNAs that target RHEB: hsa-mir-155 (MIRT001505)

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		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate RHEB (see all 30):
		hsa-miR-142-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-495 hsa-miR-3938 hsa-miR-200a hsa-miR-3653 hsa-miR-410

		SwitchGear 3'UTR luciferase reporter plasmid: RHEB 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHEB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_CNTF receptor signaling

8/14 pathways (see all 14)
Development_CNTF receptor signaling	1.00	Translation Insulin regulation of translation	0.35
Development CNTF receptor signaling	1.00	Development_Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34
Transcription Receptor-mediated HIF regulation	0.43	Development Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34
Transcription_Receptor-mediated HIF regulation	0.43	Translation _Regulation of EIF4F activity	0.32

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

Development IGF-RI signaling

	Development IGF-RI signaling	1.00			Signal transduction_AKT signaling	0.49
	Development_IGF-1 receptor signaling	0.99			Signal transduction AKT signaling	0.49

mTOR signalling

	mTOR signalling	1.00			TOR signaling	0.33
	PKB-mediated events	0.96

mTORC1-mediated signalling

	mTORC1-mediated signalling	1.00			Release of eIF4E	0.55
	S6K1-mediated signalling	0.82

Pathway sources
See GeneCards unified pathways
Show all pathways

5/12 EMD Millipore Pathways for RHEB (see all 12)

	Translation Translation regulation by Alpha-1 adrenergic receptors
	Signal transduction PTEN pathway
	Translation Insulin regulation of translation
	Translation Regulation activity of EIF4F
	Development IGF-RI signaling

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RHEB

	Molecular Mechanisms of Cancer
	mTOR Pathway

1 Cell Signaling Technology (CST) Pathway for RHEB

Translational Control

1 Tocris Bioscience Pathway for RHEB

mTOR Pathway

5/12 GeneGo (Thomson Reuters) Pathways for RHEB (see all 12)

	Development Endothelin-1/EDNRA transactivation of EGFR
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Development CNTF receptor signaling
	Signal transduction AKT signaling
	Signal transduction PTEN pathway

5/7 BioSystems Pathways for RHEB (see all 7)

	Integrated Breast Cancer Pathway
	TOR signaling
	Insulin Signaling
	Integrated Pancreatic Cancer Pathway
	FSH signaling pathway

5/16 Reactome Pathways for RHEB (see all 16)

	Release of eIF4E
	PI3K Cascade
	IGF1R signaling cascade
	mTOR signalling
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

2 Kegg Pathways (Kegg details for RHEB):

	mTOR signaling pathway
	Insulin signaling pathway

RHEB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RHEB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/52 Interacting proteins for RHEB (Q15382^{2, 3} ENSP00000262187⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MTOR	P42345²^,³, ENSP00000354558⁴	MINT-62559 MINT-62560 I2D: score=6 STRING: ENSP00000354558
RAF1	P04049²^,³, ENSP00000251849⁴	MINT-6946500 I2D: score=5 STRING: ENSP00000251849
TSC2	P49815³, ENSP00000219476⁴	I2D: score=5 STRING: ENSP00000219476
RPTOR	Q8N122³, ENSP00000307272⁴	I2D: score=4 STRING: ENSP00000307272
MLST8	Q9BVC4³, ENSP00000371888⁴	I2D: score=2 STRING: ENSP00000371888

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	--	--
GO:0007050	cell cycle arrest	TAS	--
GO:0007165	signal transduction	TAS	8661031
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0008286	insulin receptor signaling pathway	TAS	--

RHEB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RHEB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RHEB

1 HMDB Compound for RHEB About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

2 DrugBank Compounds for RHEB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Guanosine-5'-Diphosphate	--	146-91-8	target	--	17139284 17016423 10592235
Guanosine-5'-Triphosphate	--	86-01-1	target	--	17139284 17016423 10592235

6 Novoseek chemical compound relationships for RHEB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rapamycin	86.7	33	16006564 (2), 20127734 (2), 15150271 (2), 12842888 (2) (see all 19)
gtp	67.3	24	15878852 (2), 15240005 (2), 8206940 (2), 19176517 (2) (see all 12)
phosphoinositide	36.3	1	17346240 (1)
arginine	21.1	6	15340059 (2), 12214276 (1), 17371599 (1), 15240005 (1)
serine	8.97	2	12214276 (1), 18413257 (1)
glucose	0	3	19451232 (2), 17371599 (1)

Search CenterWatch for drugs/clinical trials and news about RHEB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RHEB gene:

NM_005614.3

Unigene Clusters for RHEB:

Ras homolog enriched in brain

Hs.283521 [show with all ESTs], Hs.647068 [show with all ESTs]

Unigene Representative Sequences: NR_027634, NM_005614

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262187(uc003wkh.1) ENST00000472642 ENST00000478470 ENST00000496004

ENST00000470072 ENST00000470370 ENST00000482053

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		hsa-miR-142-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-495 hsa-miR-3938 hsa-miR-200a hsa-miR-3653 hsa-miR-410

		SwitchGear 3'UTR luciferase reporter plasmid: RHEB 3' UTR sequence

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		GenScript Custom all cDNA clones Services for RHEB
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHEB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHEB

Additional cDNA sequence:

AF493921.1 AK123729.1 AK125446.1 AK289370.1 BC009638.1 BC016155.1 BC066307.1 BC107705.1

BT006958.1 Z29677.1

24/44 DOTS entries (see all 44):

DT.97855835 DT.100732507 DT.120600 DT.121289032 DT.121288941 DT.121288834 DT.91780778 DT.91963277

DT.121103402 DT.91780762 DT.91780767 DT.91780789 DT.86855463 DT.121295364 DT.121295385 DT.40274154

DT.95372211 DT.100850622 DT.121295363 DT.302945 DT.96085226 DT.100879690 DT.121103410 DT.121103479

24/612 AceView cDNA sequences (see all 612):

BM670621 AW594124 AI299436 BQ775308 BF002107 AW519065 AI917443 AI919436

CD516625 F19392 BP343100 BU726986 AI681753 CB139929 BQ012374 T28666

AA131968 AI889521 CR613801 AI991770 AA128284 BF194736 AI081221 BU608085

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHEB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCGGTGATG

About this image

RHEB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Neural Tube

Primitive Streak

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RHEB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHEB

SOURCE GeneReport for Unigene clusters: Hs.283521 Hs.647068

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382

Tissue specificity: Ubiquitous. Highest levels observed in skeletal and cardiac muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including RHEB:

mTOR Signaling in human mouse rat

PI3K-AKT Signaling Pathway in human mouse rat

Synaptic Plasticity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHEB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHEB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHEB gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RHEB¹	Ras homolog enriched in brain	88.42(n) 98.8(a)		420434 XM_001232987.2 XP_001232988.2
lizard (Anolis carolinensis)	Reptilia	RHEB⁶	--	98(a)	1 ↔ 1	6(3958466-3971570)
African clawed frog (Xenopus laevis)	Amphibia	rheb-prov²	RAS-homolog enriched in brain	82.04(n)		BC043818.1
zebrafish (Danio rerio)	Actinopterygii	zgc73144²	hypothetical protein MGC73144	80.28(n)		393702 BC059505.1
fruit fly (Drosophila melanogaster)	Insecta	Rheb⁶	Rheb	64(a)	1 ↔ 1	3R(1394618-1396213)
worm (Caenorhabditis elegans)	Secernentea	rheb-1¹	Protein RHEB-1	50.1(n) 43.93(a)		176327 NM_066678.2 NP_499079.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RHB1(YCR027C)⁴ RHB1¹	Putative Rheb-related GTPase involved in regulating more⁴ Rhb1p¹	51.12(n)¹ 40.45(a)¹		3(167999-167370)⁴ 850392^{1, 4} NP_009956.2^{1, 4}

ENSEMBL Gene Tree for RHEB (if available)
TreeFam Gene Tree for RHEB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RHEB gene

RHEBL1²

18/62 SIMAP similar genes for RHEB using alignment to 5 protein entries: RHEB_HUMAN (see all proteins) (see all similar genes):

K-RAS RHEBL1 KRAS RAP1B RRAS RRAS2

DKFZp547A0616 RALA DIRAS1 DIRAS2 RAP2B c-bas/has

HRAS RALB RAP1A RAP2A NRAS RAP2C

RHEB for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for RHEB
PGOHUM00000238773 PGOHUM00000246394 PGOHUM00000263254

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147487428^1,2		--	151162601(+)	`GAAATA/GATACT`	1	--	ds500¹		0	--	--	--	--
rs10227414^1,2	C,F,H	--	151162612(+)	`ATGCTC/TCCTCC`	1	--	ds500¹		5		NS EA WA	538
rs114156924^1,2	F	--	151162622(+)	`CACTCA/GGGAGG`	1	--	ds500¹		1		WA	118
rs73729812^1,2	C	--	151162695(+)	`CTGTTG/CTAAGT`	1	--	ds500¹		1		WA	2
rs6973428^1,2	C,F,A,H	--	151162953(+)	`CAGAGC/TGAGAC`	1	--	ds500¹		14		NS NA WA CSA EA	495
rs115191061^1,2	F	--	151163025(+)	`CAAATG/AAGGCA`	1	--	ds500¹		1		WA	118
rs149582579^1,2		--	151163078(+)	`ACATAA/GTTTTT`	1	--	ds500¹		0	--	--	--	--
rs146303853^1,2		--	151163249(+)	`GCCAC-/CAAA CAAAT`	1	--	ut3¹		0	--	--	--	--
rs144570288^1,2		--	151163278(+)	`CTTTAA/CAGCTG`	1	--	ut3¹		0	--	--	--	--
rs190849626^1,2		--	151163297(+)	`ACAGAC/GGGAGG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RHEB (151163098 - 151217206 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RHEB
1 CNV: 9588

1 SABiosciences Cancer Mutation PCR Assay for RHEB:

Cosmic Id	AA Change
33378	p.E139K

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHEB

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RHEB for disorders           About GeneDecksing

OMIM gene information: 601293    OMIM disorders: --

17 diseases for RHEB:    About MalaCards

perivascular epithelioid cell tumor tuberous sclerosis insulin resistance kidney angiomyolipoma

angiomyolipoma chronic lymphocytic leukemia lymphocytic leukemia huntington's disease

gout endometriosis leukemia lung cancer

prostate cancer hypoxia prostatitis neuronitis

carcinoma

3 diseases from the University of Copenhagen DISEASES database for RHEB:

Lymphangioleiomyomatosis Perivascular epithelioid cell tumor Angiomyolipoma

5 Novoseek disease relationships for RHEB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tuberous sclerosis	89.4	21	12906785 (1), 19262129 (1), 16627617 (1), 17371599 (1) (see all 15)
tumors	23.2	12	18787409 (2), 16006564 (1), 18708578 (1), 16636147 (1) (see all 6)
cancer	10.5	5	18787409 (2), 20127734 (1)
genetic disorder	10	1	15240005 (1)
insulin resistance	0	1	15380067 (1)

Human Genome Epidemiology (HuGE) Navigator: RHEB (3 documents)

Export disorders for RHEB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RHEB gene, integrated from 9 sources (see all 131):
(articles sorted by number of sources associating them with RHEB)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of cDNA and genomic clones of a human Ras-related GTP- binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36. (PubMed id 8661031)^{1, 2, 3} Mizuki N.... Inoko H. (1996)
Rheb binds and regulates the mTOR kinase. (PubMed id 15854902)^{1, 2, 9} Long X....Avruch J. (2005)
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. (PubMed id 15340059)^{1, 2, 9} Li Y.... Guan K.-L. (2004)
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. (PubMed id 16098514)^{1, 2, 9} Tee A.R....Proud C.G. (2005)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. (PubMed id 12869586)^{1, 2, 9} Inoki K....Guan K.L. (2003)
Structural basis for the unique biological function of small GTPase RHEB. (PubMed id 15728574)^{1, 2} Yu Y.... Ding J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PubMed id 15308774)^{1, 2} Kho Y.... Zhao Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6009	HGNC: 10011	AceView: RHEB	Ensembl:ENSG00000106615	euGenes: HUgn6009
ECgene: RHEB	Kegg: 6009	H-InvDB: RHEB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RHEB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RHEB	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RHEB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RHEB gene:
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GeneCards and IP:
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Ras homolog enriched in brain

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Ras homolog enriched in brain

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