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RHEB Gene

protein-coding   GIFtS: 70
GCID: GC07M151163

Ras Homolog Enriched In Brain

(Previous name: Ras homolog enriched in brain 2)
(Previous symbol: RHEB2)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Enriched In Brain1 2 3
RHEB21 2 3 5
Ras Homolog Enriched In Brain 21 2
GTP-Binding Protein Rheb2

External Ids:    HGNC: 100111   Entrez Gene: 60092   Ensembl: ENSG000001066157   OMIM: 6012935   UniProtKB: Q153823   

Export aliases for RHEB gene to outside databases

Previous GC identifers: GC07M150478 GC07M150555 GC07M150554 GC07M150600 GC07M150794 GC07M144974


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHEB Gene:
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with
five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle
progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and
shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this
activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RHEB Gene:
RHEB (Ras homolog enriched in brain) is a protein-coding gene. Diseases associated with RHEB include kidney angiomyolipoma, and tuberous sclerosis complex. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382
Function: Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates
the protein kinase activity of mTORC1. Has low intrinsic GTPase activity

Gene Wiki entry for RHEB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHEB gene promoter:
         Elk-1   p53   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHEB promoter sequence
   Search Chromatin IP Primers for RHEB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHEB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

RHEB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHEB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M151163:  view genomic region     (about GC identifiers)

Start:
151,163,098 bp from pter      End:
151,217,206 bp from pter
Size:
54,109 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,492,679-150,546,598     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382 (See protein sequence)
Recommended Name: GTP-binding protein Rheb precursor  
Size: 184 amino acids; 20497 Da
Subunit: Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR.
Interacts with TSC2
Miscellaneous: The conserved catalytic Gln-64 found in other Ras-like GTPases seems not to be involved in GTP
hydrolysis in RHEB
5 PDB 3D structures from and Proteopedia for RHEB:
1XTQ (3D)        1XTR (3D)        1XTS (3D)        3SEA (3D)        3T5G (3D)    
Secondary accessions: B3KWN6 D3DX13 Q53Y56 Q99444

Explore the universe of human proteins at neXtProt for RHEB: NX_Q15382

Explore proteomics data for RHEB at MOPED

Post-translational modifications: 

  • Farnesylation is important for efficiently activating mTORC1-mediated signaling1
  • Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation (By similarity)1
  • Ubiquitination2 at Lys109, Lys135, Lys151, Lys169
  • Modification sites at PhosphoSitePlus

  • See RHEB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005605.1  
    ENSEMBL proteins: 
     ENSP00000262187   ENSP00000420726   ENSP00000417802   ENSP00000418161   ENSP00000417212  
    Reactome Protein details: Q15382

    RHEB Human Recombinant Protein Products:

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    Novus Biologicals RHEB Proteins
    Novus Biologicals RHEB Lysates
    Sino Biological Recombinant Protein for RHEB
    Sino Biological Cell Lysate for RHEB
    ProSpec Recombinant Protein for RHEB
    Cloud-Clone Corp. Proteins for RHEB

    RHEB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RHEB
    R&D Systems Antibodies for RHEB
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    Novus Biologicals RHEB Antibodies
    Abcam antibodies for RHEB
    Cloud-Clone Corp. Antibodies for RHEB
    ThermoFisher Antibodies for RHEB
    LSBio Antibodies in human, mouse, rat for RHEB

    RHEB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RHEB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RHEB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHEB
    Cloud-Clone Corp. CLIAs for RHEB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q15382

    ProtoNet protein and cluster: Q15382

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382
    Similarity: Belongs to the small GTPase superfamily. Rheb family


    RHEB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHEB_HUMAN, Q15382
    Function: Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates
    the protein kinase activity of mTORC1. Has low intrinsic GTPase activity
    Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated
    by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8206940
    GO:0005515protein binding IPI--
    GO:0005525GTP binding ISS--
    GO:0019003GDP binding IEA--
    GO:0019901protein kinase binding IEA--
         
    RHEB for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rheb):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  normal 

    RHEB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RHEB: Rhebtm1.1Pfw Rhebtm1.1Yelg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHEB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHEB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHEB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHEB

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHEB:
    hsa-mir-18a-3p (MIRT040755), hsa-mir-92a-3p (MIRT049778), hsa-mir-744-5p (MIRT037399), hsa-mir-155-5p (MIRT001505)

    Block miRNA regulation of human, mouse, rat RHEB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHEB (see all 30):
    hsa-miR-142-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-495 hsa-miR-3938 hsa-miR-200a hsa-miR-3653 hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidRHEB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RHEB
    Predesigned siRNA for gene silencing in human, mouse, rat RHEB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHEB

    Clone
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    OriGene clones in human, mouse for RHEB (see all 7)
    OriGene ORF clones in mouse, rat for RHEB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for RHEB
    Sino Biological Human cDNA Clone for RHEB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHEB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHEB

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RHEB
    Browse ESI BIO Cell Lines and PureStem Progenitors for RHEB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHEB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHEB_HUMAN, Q15382: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    mitochondrion3
    nucleus2
    vacuole2
    endosome1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005681spliceosomal complex IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS8206940

    RHEB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHEB About   (see all 20)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    PKB-mediated events0.41
    IRS-related events0.94
    mTOR signalling0.39
    IRS-mediated signalling0.92
    TOR signaling0.32
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    Energy dependent regulation of mTOR by LKB1-AMPK0.00
    3Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Transcription Receptor mediated HIF regulation0.51
    mTOR signaling pathway0.34
    Translation Regulation activity of EIF4F0.44
    Insulin signaling pathway0.32
    4Translation Translation regulation by Alpha 1 adrenergic receptors
    Translation Translation regulation by Alpha 1 adrenergic receptors0.64
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RHEB
        Akt Signaling Pathway

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RHEB
        Molecular Mechanisms of Cancer
    mTOR Pathway

    1 Tocris Bioscience Pathway for RHEB
        mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for RHEB (see all 12)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development CNTF receptor signaling
    Signal transduction AKT signaling
    Signal transduction PTEN pathway

    Selected BioSystems Pathways for RHEB (see all 7)
        TOR signaling
    Insulin Signaling
    Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Prostate Cancer


    4 Reactome Pathways for RHEB
        Release of eIF4E
    Regulation of Rheb GTPase activity by AMPK
    S6K1-mediated signalling
    mTOR signalling


    4 Kegg Pathways  (Kegg details for RHEB):
        mTOR signaling pathway
    PI3K-Akt signaling pathway
    Insulin signaling pathway
    Thyroid hormone signaling pathway


    RHEB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RHEB: 
              mTOR Signaling in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RHEB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHEB (Q153821, 2, 3 ENSP000002621874) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTORP423452, 3, ENSP000003545584MINT-62559 MINT-62560 I2D: score=6 STRING: ENSP00000354558
    RAF1P040492, 3, ENSP000002518494MINT-6946500 I2D: score=5 STRING: ENSP00000251849
    PDE6DO439241, 3, ENSP000002876004EBI-6860739,EBI-712685 I2D: score=3 STRING: ENSP00000287600
    TSC2P498153, ENSP000002194764I2D: score=5 STRING: ENSP00000219476
    RPTORQ8N1223, ENSP000003072724I2D: score=4 STRING: ENSP00000307272
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007050cell cycle arrest TAS--
    GO:0007165signal transduction TAS8661031
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0008286insulin receptor signaling pathway TAS--

    RHEB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHEB

    1 HMDB Compound for RHEB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for RHEB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423 10592235

    6 Novoseek inferred chemical compound relationships for RHEB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 86.7 33 16006564 (2), 20127734 (2), 15150271 (2), 12842888 (2) (see all 19)
    gtp 67.3 24 15878852 (2), 15240005 (2), 8206940 (2), 19176517 (2) (see all 12)
    phosphoinositide 36.3 1 17346240 (1)
    arginine 21.1 6 15340059 (2), 12214276 (1), 17371599 (1), 15240005 (1)
    serine 8.97 2 12214276 (1), 18413257 (1)
    glucose 0 3 19451232 (2), 17371599 (1)



    RHEB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RHEB gene: 
    NM_005614.3  

    Unigene Clusters for RHEB:

    Ras homolog enriched in brain
    Hs.283521  [show with all ESTs], Hs.647068  [show with all ESTs]
    Unigene Representative Sequences: NR_027634, NM_005614
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262187(uc003wkh.1) ENST00000472642 ENST00000478470 ENST00000496004
    ENST00000470072 ENST00000470370 ENST00000482053
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RHEB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHEB (see all 30):
    hsa-miR-142-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-495 hsa-miR-3938 hsa-miR-200a hsa-miR-3653 hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidRHEB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHEB
    Clone
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    OriGene clones in human, mouse for RHEB (see all 7)
    OriGene ORF clones in mouse, rat for RHEB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for RHEB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHEB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHEB
    Primer
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    OriGene qPCR primer pairs and template standards for RHEB
    OriGene qSTAR qPCR primer pairs in human, mouse for RHEB
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RHEB
      QuantiTect SYBR Green Assays in human, mouse, rat RHEB
      QuantiFast Probe-based Assays in human, mouse, rat RHEB

    Additional mRNA sequence: 

    AF493921.1 AK123729.1 AK125446.1 AK289370.1 BC009638.1 BC016155.1 BC066307.1 BC107705.1 
    BT006958.1 Z29677.1 

    Selected DOTS entries (see all 42):

    DT.97855835  DT.100732507  DT.120600  DT.121289032  DT.121288941  DT.121288834  DT.91780778  DT.91963277 
    DT.121103402  DT.91780762  DT.91780767  DT.91780789  DT.86855463  DT.121295364  DT.121295385  DT.40274154 
    DT.95372211  DT.100850622  DT.121295363  DT.302945  DT.96085226  DT.100879690  DT.121103410  DT.121103479 

    Selected AceView cDNA sequences (see all 612):

    AI961116 AA903010 CA446650 AI081221 AA665112 AI302378 D57978 BM773404 
    BU623118 AA128284 AI919436 CA849027 AA370312 BF002107 BM695744 BM754700 
    BM852654 R96364 BF194736 AI953617 AW069839 CB139929 AI681753 AI917443 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHEB expression in normal human tissues (normalized intensities)      RHEB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGGTGATG
    RHEB Expression
    About this image


    RHEB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
     
     Neural Tube (Nervous System)
             Telencephalon
    RHEB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHEB Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.283521 Hs.647068

    UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382
    Tissue specificity: Ubiquitous. Highest levels observed in skeletal and cardiac muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RHEB: 
              mTOR Signaling in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHEB
    OriGene qSTAR qPCR primer pairs in human, mouse for RHEB
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RHEB
    QuantiTect SYBR Green Assays in human, mouse, rat RHEB
    QuantiFast Probe-based Assays in human, mouse, rat RHEB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHEB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHEB gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rheb1 , 5 Ras homolog enriched in brain1, 5 92.57(n)1
    98.91(a)1
      5 (11.93 cM)5
    197441  NM_053075.31  NP_444305.21 
     248028235 
    chicken
    (Gallus gallus)
    Aves RHEB1 Ras homolog enriched in brain 88.42(n)
    98.8(a)
      420434  XM_001232987.3  XP_001232988.3 
    lizard
    (Anolis carolinensis)
    Reptilia RHEB6
    Ras homolog enriched in brain
    84(a)
    1 ↔ 1
    6(3956128-3972657)
    African clawed frog
    (Xenopus laevis)
    Amphibia rheb-prov2 RAS-homolog enriched in brain 82.04(n)    BC043818.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731442 hypothetical protein MGC73144 80.28(n)   393702  BC059505.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rheb6
    Rheb
    64(a)
    1 → many
    3R(1394618-1396213)
    worm
    (Caenorhabditis elegans)
    Secernentea rheb-11 rheb-1 50.1(n)
    43.93(a)
      176327  NM_066678.3  NP_499079.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHB1(YCR027C)4
    RHB11
    Putative Rheb-related GTPase involved in regulating more4
    RHB11
    51.12(n)1
    40.45(a)1
      3(167999-167370)4
    8503921, 4  NP_009956.21, 4 


    ENSEMBL Gene Tree for RHEB (if available)
    TreeFam Gene Tree for RHEB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHEB gene
    RASL122  RASL11A2  RERGL2  RASL11B2  RHEBL12  RERG2  
    Selected SIMAP similar genes for RHEB using alignment to 5 protein entries:     RHEB_HUMAN (see all proteins) (see all similar genes):
    K-RAS    RHEBL1    KRAS    RAP1B    RRAS    RRAS2
    DKFZp547A0616    RALA    DIRAS1    DIRAS2    RAP2B    c-bas/has
    HRAS    RALB    RAP1A    RAP2A    NRAS    RAP2C

    RHEB for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RHEB
    PGOHUM00000238773 PGOHUM00000246394 PGOHUM00000263254


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHEB (see all 1073)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363104
    A colorectal cancer sample4--see VAR_0363102 E K mis40--------
    rs1474874281,2
    --151162601(+) GAAATA/GATACT 1 -- ds50010--------
    rs102274141,2
    C,F,H--151162612(+) ATGCTC/TCCTCC 1 -- ds50015Minor allele frequency- T:0.02NS EA WA 538
    rs1141569241,2
    C,F--151162622(+) CACTCA/GGGAGG 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs737298121,2
    C,F--151162695(+) CTGTTG/CTAAGT 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs69734281,2
    C,F,A,H--151162953(+) CAGAGC/TGAGAC 1 -- ds500114Minor allele frequency- T:0.10NS NA WA CSA EA 495
    rs1151910611,2
    C,F--151163025(+) CAAATG/AAGGCA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1495825791,2
    --151163078(+) ACATAA/GTTTTT 1 -- ds50010--------
    rs1463038531,2
    C--151163249(+) GCCAC-/CAAA  
            
    CAAAT
    1 -- ut310--------
    rs1445702881,2
    --151163278(+) CTTTAA/CAGCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RHEB (151163098 - 151217206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RHEB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6006CNV Insertion18451855
    nsv824394CNV Gain20364138
    nsv831189CNV Gain17160897
    nsv818570CNV Gain17921354

    1 Site Specific Mutation Identification with PCR Assay for RHEB:
    Cosmic IdAA Change
    33378p.E139K
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RHEB
    DNA2.0 Custom Variant and Variant Library Synthesis for RHEB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601293    OMIM disorders: --

    Selected diseases for RHEB (see all 23):    About MalaCards
    kidney angiomyolipoma    tuberous sclerosis complex    tuberous sclerosis    angiomyolipoma
    perivascular epithelioid cell tumor    lymphangioleiomyomatosis    gout    insulin resistance
    endometriosis    huntington's disease    breast and colorectal cancer    chronic lymphocytic leukemia
    pancreatic cancer    hypoxia    pancreatitis    prostate cancer
    alzheimer's disease    lung cancer    prostatitis    leukemia

    4 diseases from the University of Copenhagen DISEASES database for RHEB:
    Tuberous sclerosis     Lymphangioleiomyomatosis     Perivascular epithelioid cell tumor     Angiomyolipoma

    RHEB for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for RHEB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 89.4 21 12906785 (1), 19262129 (1), 16627617 (1), 17371599 (1) (see all 15)
    tumors 23.2 12 18787409 (2), 16006564 (1), 18708578 (1), 16636147 (1) (see all 6)
    cancer 10.5 5 18787409 (2), 20127734 (1)
    genetic disorder 10 1 15240005 (1)
    insulin resistance 0 1 15380067 (1)

    Genetic Association Database (GAD): RHEB
    Human Genome Epidemiology (HuGE) Navigator: RHEB (3 documents)

    Export disorders for RHEB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHEB gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with RHEB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA and genomic clones of a human Ras-related GTP- binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36. (PubMed id 8661031)1, 2, 3 Mizuki N.... Inoko H. (Genomics 1996)
    2. Rheb binds and regulates the mTOR kinase. (PubMed id 15854902)1, 2, 9 Long X.... Avruch J. (Curr. Biol. 2005)
    3. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. (PubMed id 15340059)1, 2, 9 Li Y.... Guan K.-L. (Mol. Cell. Biol. 2004)
    4. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. (PubMed id 16098514)1, 2, 9 Tee A.R.... Proud C.G. (FEBS Lett. 2005)
    5. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. (PubMed id 12869586)1, 2, 9 Inoki K.... Guan K.-L. (Genes Dev. 2003)
    6. Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer. (PubMed id 20354165)1, 4 Lin J....Wu X. (Cancer Prev Res (Phila) 2010)
    7. Structural basis for the unique biological function of small GTPase RHEB. (PubMed id 15728574)1, 2 Yu Y.... Ding J. (J. Biol. Chem. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PubMed id 15308774)1, 2 Kho Y.... Zhao Y. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6009 HGNC: 10011 AceView: RHEB Ensembl:ENSG00000106615 euGenes: HUgn6009
    ECgene: RHEB Kegg: 6009 H-InvDB: RHEB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RHEB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHEB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHEB gene:
    Search GeneIP for patents involving RHEB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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