Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHEB Gene

protein-coding   GIFtS: 70
GCID: GC07M151163

Ras Homolog Enriched In Brain

(Previous name: Ras homolog enriched in brain 2)
(Previous symbol: RHEB2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Homolog Enriched In Brain1 2 3
RHEB21 2 3 5
Ras Homolog Enriched In Brain 21 2
GTP-Binding Protein Rheb2

External Ids:    HGNC: 100111   Entrez Gene: 60092   Ensembl: ENSG000001066157   OMIM: 6012935   UniProtKB: Q153823   

Export aliases for RHEB gene to outside databases

Previous GC identifers: GC07M150478 GC07M150555 GC07M150554 GC07M150600 GC07M150794 GC07M144974


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHEB Gene:
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with
five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle
progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and
shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this
activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RHEB Gene: 
RHEB (Ras homolog enriched in brain) is a protein-coding gene. Diseases associated with RHEB include kidney angiomyolipoma, and tuberous sclerosis complex, and among its related super-pathways are Signal transduction AKT signaling and Translation Insulin regulation of translation. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382
Function: Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates
the protein kinase activity of mTORC1. Has low intrinsic GTPase activity

Gene Wiki entry for RHEB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHEB gene promoter:
         Elk-1   p53   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHEB promoter sequence
   Search SABiosciences Chromatin IP Primers for RHEB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHEB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

RHEB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHEB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M151163:  view genomic region     (about GC identifiers)

Start:
151,163,098 bp from pter      End:
151,217,206 bp from pter
Size:
54,109 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,492,679-150,546,598     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382 (See protein sequence)
Recommended Name: GTP-binding protein Rheb precursor  
Size: 184 amino acids; 20497 Da
Subunit: Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR.
Interacts with TSC2
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Miscellaneous: The conserved catalytic Gln-64 found in other Ras-like GTPases seems not to be involved in GTP
hydrolysis in RHEB
5 PDB 3D structures from and Proteopedia for RHEB:
1XTQ (3D)        1XTR (3D)        1XTS (3D)        3SEA (3D)        3T5G (3D)    
Secondary accessions: B3KWN6 D3DX13 Q53Y56 Q99444

Explore the universe of human proteins at neXtProt for RHEB: NX_Q15382

Explore proteomics data for RHEB at MOPED 

Post-translational modifications:

  • UniProtKB: Farnesylation is important for efficiently activating mTORC1-mediated signaling
  • UniProtKB: Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15382

  • RHEB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHEB Protein Expression
    REFSEQ proteins: NP_005605.1  
    ENSEMBL proteins: 
     ENSP00000262187   ENSP00000420726   ENSP00000417802   ENSP00000418161   ENSP00000417212  
    Reactome Protein details: Q15382
    Human Recombinant Protein Products for RHEB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RHEB
    OriGene Protein Over-expression Lysate for RHEB
    OriGene MassSpec for RHEB 
    OriGene Custom Protein Services for RHEB
    GenScript Custom Purified and Recombinant Proteins Services for RHEB
    Novus Biologicals RHEB Proteins
    Novus Biologicals RHEB Lysates
    Sino Biological Recombinant Protein for RHEB
    Sino Biological Cell Lysate for RHEB 
    ProSpec Recombinant Protein for RHEB
    Cloud-Clone Corp. Proteins for RHEB 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005681spliceosomal complex IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS8206940

    RHEB for ontologies           About GeneDecksing



    RHEB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RHEB
    R&D Systems Antibodies for RHEB
    OriGene Antibodies for RHEB
    OriGene Custom Antibody Services for RHEB
    GenScript Custom Superior Antibodies Services for RHEB
    Novus Biologicals RHEB Antibodies
    Abcam antibodies for RHEB
    Cloud-Clone Corp. Antibodies for RHEB 
    ThermoFisher Antibodies for RHEB
    LSBio Antibodies in human, mouse, rat for RHEB 

    Assay Products for RHEB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RHEB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RHEB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHEB 
    Cloud-Clone Corp. CLIAs for RHEB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q15382

    ProtoNet protein and cluster: Q15382

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382
    Similarity: Belongs to the small GTPase superfamily. Rheb family


    RHEB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHEB_HUMAN, Q15382
    Function: Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates
    the protein kinase activity of mTORC1. Has low intrinsic GTPase activity
    Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated
    by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005525GTP binding ISS--
    GO:0019003GDP binding IEA--
    GO:0019901protein kinase binding IEA--
         
    RHEB for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rheb):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  normal 

    RHEB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RHEB: Rhebtm1.1Pfw Rhebtm1.1Yelg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHEB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHEB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHEB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHEB 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHEB:
    hsa-mir-155 (MIRT001505)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHEB
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate RHEB (see all 30):
    hsa-miR-142-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-495 hsa-miR-3938 hsa-miR-200a hsa-miR-3653 hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidRHEB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHEB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHEB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHEB
    Sirion Biotech Customized adenovirus for overexpression of RHEB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RHEB (see all 7)
    OriGene ORF clones in mouse, rat for RHEB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for RHEB
    Sino Biological Human cDNA Clone for RHEB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHEB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHEB
    Sirion Biotech Customized lentivirus for stable overexpression of RHEB 
                         Customized lentivirus expression plasmids for stable overexpression of RHEB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RHEB
    Search LifeMap BioReagents cell lines for RHEB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHEB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHEB About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling:generic cascades0.59
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    Transcription Receptor-mediated HIF regulation0.51
    mTOR signaling pathway0.34
    Translation Regulation activity of EIF4F0.44
    Insulin signaling pathway0.31
    3Energy dependent regulation of mTOR by LKB1-AMPK
    Energy dependent regulation of mTOR by LKB1-AMPK0.82
    Regulation of Rheb GTPase activity by AMPK0.59
    mTOR signalling0.63
    TOR signaling0.33
    PKB-mediated events0.61
    4IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79
    5mTORC1-mediated signalling
    mTORC1-mediated signalling0.82
    Release of eIF4E0.55
    S6K1-mediated signalling0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/12 EMD Millipore Pathways for RHEB (see all 12)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Signal transduction PTEN pathway
    Translation Insulin regulation of translation
    Translation Regulation activity of EIF4F
    Development IGF-RI signaling

    1 R&D Systems Pathway for RHEB
        Akt Signaling Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RHEB
        Molecular Mechanisms of Cancer
    mTOR Pathway

    1 Tocris Bioscience Pathway for RHEB
        mTOR Pathway

    5/12 GeneGo (Thomson Reuters) Pathways for RHEB (see all 12)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development CNTF receptor signaling
    Signal transduction AKT signaling
    Signal transduction PTEN pathway

    5/7 BioSystems Pathways for RHEB (see all 7)
        TOR signaling
    Insulin Signaling
    Integrated Breast Cancer Pathway
    FSH signaling pathway
    Prostate Cancer


    5/16        Reactome Pathways for RHEB (see all 16)
        Release of eIF4E
    PI3K Cascade
    IGF1R signaling cascade
    mTOR signalling
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)


    3         Kegg Pathways  (Kegg details for RHEB):
        mTOR signaling pathway
    PI3K-Akt signaling pathway
    Insulin signaling pathway


    RHEB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHEB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for RHEB (Q153822, 3 ENSP000002621874) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTORP423452, 3, ENSP000003545584MINT-62559 MINT-62560 I2D: score=6 STRING: ENSP00000354558
    RAF1P040492, 3, ENSP000002518494MINT-6946500 I2D: score=5 STRING: ENSP00000251849
    TSC2P498153, ENSP000002194764I2D: score=5 STRING: ENSP00000219476
    RPTORQ8N1223, ENSP000003072724I2D: score=4 STRING: ENSP00000307272
    MLST8Q9BVC43, ENSP000003718884I2D: score=2 STRING: ENSP00000371888
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007050cell cycle arrest TAS--
    GO:0007165signal transduction TAS8661031
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0008286insulin receptor signaling pathway TAS--

    RHEB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHEB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHEB

    1 HMDB Compound for RHEB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for RHEB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423 10592235

    6 Novoseek inferred chemical compound relationships for RHEB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 86.7 33 16006564 (2), 20127734 (2), 15150271 (2), 12842888 (2) (see all 19)
    gtp 67.3 24 15878852 (2), 15240005 (2), 8206940 (2), 19176517 (2) (see all 12)
    phosphoinositide 36.3 1 17346240 (1)
    arginine 21.1 6 15340059 (2), 12214276 (1), 17371599 (1), 15240005 (1)
    serine 8.97 2 12214276 (1), 18413257 (1)
    glucose 0 3 19451232 (2), 17371599 (1)

    Search CenterWatch for drugs/clinical trials and news about RHEB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHEB gene: 
    NM_005614.3  

    Unigene Clusters for RHEB:

    Ras homolog enriched in brain
    Hs.283521  [show with all ESTs], Hs.647068  [show with all ESTs]
    Unigene Representative Sequences: NR_027634, NM_005614
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262187(uc003wkh.1) ENST00000472642 ENST00000478470 ENST00000496004
    ENST00000470072 ENST00000470370 ENST00000482053
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHEB
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate RHEB (see all 30):
    hsa-miR-142-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-495 hsa-miR-3938 hsa-miR-200a hsa-miR-3653 hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidRHEB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHEB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHEB
    Clone
    Products:
         
    OriGene clones in human, mouse for RHEB (see all 7)
    OriGene ORF clones in mouse, rat for RHEB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for RHEB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHEB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHEB
    Sirion Biotech Customized lentivirus for stable overexpression of RHEB 
                         Customized lentivirus expression plasmids for stable overexpression of RHEB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHEB
    OriGene qSTAR qPCR primer pairs in human, mouse for RHEB
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RHEB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHEB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHEB

    Additional mRNA sequence: 

    AF493921.1 AK123729.1 AK125446.1 AK289370.1 BC009638.1 BC016155.1 BC066307.1 BC107705.1 
    BT006958.1 Z29677.1 

    24/42 DOTS entries (see all 42):

    DT.97855835  DT.100732507  DT.120600  DT.121289032  DT.121288941  DT.121288834  DT.91780778  DT.91963277 
    DT.121103402  DT.91780762  DT.91780767  DT.91780789  DT.86855463  DT.121295364  DT.121295385  DT.40274154 
    DT.95372211  DT.100850622  DT.121295363  DT.302945  DT.96085226  DT.100879690  DT.121103410  DT.121103479 

    24/612 AceView cDNA sequences (see all 612):

    CD516625 AI277352 BM754700 AW519065 AA910478 AW594124 BU608085 CA446650 
    W76445 AI917443 AI299436 BM975354 AI919436 BF593727 BF002107 BM695744 
    BQ271044 AI651808 BP343100 F19392 AA665112 BM670621 AI953617 N76110 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHEB expression in normal human tissues (normalized intensities)      RHEB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGGTGATG
    RHEB Expression
    About this image


    RHEB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Intervertebral Disc Nucleus Pulposus Cells Lumbar Intervertebral Disc
             sensory organ/ear/inner ear   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             umbilical cord reticulocytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             sensory organ/ear/inner ear   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/chondrocranium   
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord

    See RHEB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHEB

    SOURCE GeneReport for Unigene clusters: Hs.283521 Hs.647068

    UniProtKB/Swiss-Prot: RHEB_HUMAN, Q15382
    Tissue specificity: Ubiquitous. Highest levels observed in skeletal and cardiac muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including RHEB: 
              mTOR Signaling in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHEB
    OriGene qSTAR qPCR primer pairs in human, mouse for RHEB
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RHEB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHEB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHEB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHEB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHEB gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rheb1 , 5 Ras homolog enriched in brain1, 5 92.57(n)1
    98.91(a)1
      5 (11.93 cM)5
    197441  NM_053075.31  NP_444305.21 
     248028235 
    chicken
    (Gallus gallus)
    Aves RHEB1 Ras homolog enriched in brain 88.42(n)
    98.8(a)
      420434  XM_001232987.2  XP_001232988.2 
    lizard
    (Anolis carolinensis)
    Reptilia RHEB6
    Ras homolog enriched in brain
    84(a)
    1 ↔ 1
    6(3956128-3972657)
    African clawed frog
    (Xenopus laevis)
    Amphibia rheb-prov2 RAS-homolog enriched in brain 82.04(n)    BC043818.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731442 hypothetical protein MGC73144 80.28(n)   393702  BC059505.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rheb6
    Rheb
    63(a)
    1 → many
    3R(1394618-1396213)
    worm
    (Caenorhabditis elegans)
    Secernentea rheb-11 Protein RHEB-1 50.1(n)
    43.93(a)
      176327  NM_066678.2  NP_499079.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RHB1(YCR027C)4
    RHB11
    Putative Rheb-related GTPase involved in regulating more4
    Rhb1p1
    51.12(n)1
    40.45(a)1
      3(167999-167370)4
    8503921, 4  NP_009956.21, 4 


    ENSEMBL Gene Tree for RHEB (if available)
    TreeFam Gene Tree for RHEB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHEB gene
    RASL122  RASL11A2  RERGL2  RASL11B2  RHEBL12  RERG2  
    18/61 SIMAP similar genes for RHEB using alignment to 5 protein entries:     RHEB_HUMAN (see all proteins) (see all similar genes):
    K-RAS    RHEBL1    KRAS    RAP1B    RRAS    RRAS2
    DKFZp547A0616    RALA    DIRAS1    DIRAS2    RAP2B    c-bas/has
    HRAS    RALB    RAP1A    RAP2A    NRAS    RAP2C

    RHEB for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RHEB
    PGOHUM00000238773 PGOHUM00000246394 PGOHUM00000263254


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1073 SNPs in RHEB are shown (see all 1073)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363104
    A colorectal cancer sample4--see VAR_0363102 E K mis40--------
    rs1474874281,2
    --151162601(+) GAAATA/GATACT 1 -- ds50010--------
    rs102274141,2
    C,F,H--151162612(+) ATGCTC/TCCTCC 1 -- ds50015Minor allele frequency- T:0.02NS EA WA 538
    rs1141569241,2
    C,F--151162622(+) CACTCA/GGGAGG 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs737298121,2
    C,F--151162695(+) CTGTTG/CTAAGT 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs69734281,2
    C,F,A,H--151162953(+) CAGAGC/TGAGAC 1 -- ds500114Minor allele frequency- T:0.10NS NA WA CSA EA 495
    rs1151910611,2
    C,F--151163025(+) CAAATG/AAGGCA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1495825791,2
    --151163078(+) ACATAA/GTTTTT 1 -- ds50010--------
    rs1463038531,2
    C--151163249(+) GCCAC-/CAAA  
            
    CAAAT
    1 -- ut310--------
    rs1445702881,2
    --151163278(+) CTTTAA/CAGCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RHEB (151163098 - 151217206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RHEB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6006CNV Insertion18451855
    nsv824394CNV Gain20364138
    nsv831189CNV Gain17160897
    nsv818570CNV Gain17921354

    1 SABiosciences Cancer Mutation PCR Assay for RHEB:
    Cosmic IdAA Change
    33378p.E139K
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RHEB
    DNA2.0 Custom Variant and Variant Library Synthesis for RHEB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601293    OMIM disorders: --

    20/21 diseases for RHEB (see all 21):    About MalaCards
    kidney angiomyolipoma    tuberous sclerosis complex    tuberous sclerosis    perivascular epithelioid cell tumor
    angiomyolipoma    lymphangioleiomyomatosis    gout    insulin resistance
    endometriosis    huntington's disease    chronic lymphocytic leukemia    hypoxia
    pancreatic cancer    lung cancer    prostate cancer    leukemia
    alzheimer's disease    prostatitis    pancreatitis    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for RHEB:
    Tuberous sclerosis     Lymphangioleiomyomatosis     Perivascular epithelioid cell tumor     Angiomyolipoma

    RHEB for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for RHEB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 89.4 21 12906785 (1), 19262129 (1), 16627617 (1), 17371599 (1) (see all 15)
    tumors 23.2 12 18787409 (2), 16006564 (1), 18708578 (1), 16636147 (1) (see all 6)
    cancer 10.5 5 18787409 (2), 20127734 (1)
    genetic disorder 10 1 15240005 (1)
    insulin resistance 0 1 15380067 (1)

    Genetic Association Database (GAD): RHEB
    Human Genome Epidemiology (HuGE) Navigator: RHEB (3 documents)

    Export disorders for RHEB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHEB gene, integrated from 9 sources (see all 135):
    (articles sorted by number of sources associating them with RHEB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA and genomic clones of a human Ras-related GTP- binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36. (PubMed id 8661031)1, 2, 3 Mizuki N.... Inoko H. (1996)
    2. Rheb binds and regulates the mTOR kinase. (PubMed id 15854902)1, 2, 9 Long X....Avruch J. (2005)
    3. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. (PubMed id 15340059)1, 2, 9 Li Y.... Guan K.-L. (2004)
    4. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. (PubMed id 16098514)1, 2, 9 Tee A.R....Proud C.G. (2005)
    5. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. (PubMed id 12869586)1, 2, 9 Inoki K....Guan K.L. (2003)
    6. Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer. (PubMed id 20354165)1, 4 Lin J....Wu X. (2010)
    7. Structural basis for the unique biological function of small GTPase RHEB. (PubMed id 15728574)1, 2 Yu Y.... Ding J. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PubMed id 15308774)1, 2 Kho Y.... Zhao Y. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6009 HGNC: 10011 AceView: RHEB Ensembl:ENSG00000106615 euGenes: HUgn6009
    ECgene: RHEB Kegg: 6009 H-InvDB: RHEB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHEB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHEB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHEB gene:
    Search GeneIP for patents involving RHEB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RHEB
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RHEB (Rheb)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RHEB   OriGene RNAi products in human, mouse, rat for RHEB  
     OriGene qPCR primer pairs and template standards for RHEB   OriGene Protein Over-expression Lysate for RHEB  
     OriGene MassSpec something-or-other for RHEB   OriGene clones in human, mouse for RHEB  
     OriGene qSTAR qPCR primer pairs in human, mouse for RHEB   OriGene Purified Protein for RHEB  
     OriGene ORF clones in mouse, rat for RHEB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RHEB   OriGene Custom Protein Services for RHEB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHEB
     QIAGEN SeqTarget long-range PCR primers for resequencing RHEB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHEB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHEB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHEB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHEB
     GenScript Custom Purified and Recombinant Proteins Services for RHEB GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for RHEB
     GenScript Custom Assay Services for RHEB GenScript Custom Superior Antibodies Services for RHEB
     GenScript Custom overexpressing Cell Line Services for RHEB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RHEB promoter
     Search Chromatin IP Primers for RHEB
     RT2 qPCR Primer Assay in human, mouse / rat RHEB
     GNC Network for RHEB
     SABiosciences PCR Arrays including human, mouse / rat RHEB
     Search Tocris compounds for RHEB
     Proteins and Antibodies for RHEB
     Cell Lysates for RHEB
     cDNA Clones for RHEB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RHEB antibodies
     RHEB proteins
     RHEB lysates
     Antibodies for RHEB
     See all of Abcam's Antibodies, Kits and Proteins for RHEB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RHEB




     Proteins for RHEB
     Antibodies for RHEB
     ELISAs for RHEB
     CLIAs for RHEB
     Search LifeMap BioReagents cell lines for RHEB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHEB
     SwitchGear 3'UTR luciferase reporter plasmids for RHEB
     SwitchGear Promoter luciferase reporter plasmids for RHEB
     ThermoFisher Antibodies for RHEB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHEB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RHEB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHEB
    Customized:
     lentivirus for stable overexpression of RHEB
     lentivirus expression plasmids for stable overexpression of RHEB
     adenovirus for overexpression of RHEB
     LSBio Antibodies in human, mouse, rat for RHEB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RHEB gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4