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RHD Gene

protein-coding GIFtS: 56
GCID: GC01P025599

Rh Blood Group, D Antigen

(Previous names: Rhesus blood group, D antigen, Rh blood group, D antigen)
(Previous symbol: RH)

See RHD-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Rh Blood Group, D Antigen¹ ²		Rh4²
RH¹ ²		RhDCw²
Rh Polypeptide 2² ³		RhII²
Rhesus D Antigen² ³		RhK562-II²
RHXIII² ³		RhPI²
Rhesus Blood Group, D Antigen¹		Blood Group Rh(D) Polypeptide²
CD240D²		D Antigen (DCS)²
DIIIc²		Rh Blood Group Antigen Evans²
RH30²		Rh Blood Group, D Anitgen²
RHCED²		Rhesus Blood Group D Antigen Allele DIII Type 7²
RHDVA(TT)²		Rhesus System D Polypeptide²
RHDel²		RhPII³
RHPII²		CD240D Antigen³

External Ids:	HGNC: 10009¹	Entrez Gene: 6007²	Ensembl: ENSG00000187010⁷	OMIM: 111680⁵	UniProtKB: Q02161³

Export aliases for RHD gene to outside databases

Previous GC identifers: GC01M025154 GC01M024859 GC01M024598 GC01P025154 GC01P025344 GC01P025471 GC01P023853

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHD Gene:

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is

also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense

mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes

both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a

cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the

presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RHD Gene:

RHD (Rh blood group, D antigen) is a protein-coding gene. Diseases associated with RHD include acanthocytosis, and uremia. GO annotations related to this gene include ammonium transmembrane transporter activity. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161

Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the

erythrocyte membrane

Gene Wiki entry for RHD Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NC_018912.2 NT_032977.10

Regulatory elements:

Regulatory transcription factor binding sites in the RHD gene promoter:
SRF SRF (504 AA) Chx10 MyoD STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHD promoter sequence

Search Chromatin IP Primers for RHD

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11

RHD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHD gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P025599: view genomic region (about GC identifiers)

Start:	25,598,884 bp from pter	End:	25,656,936 bp from pter
Size:	58,053 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161 (See protein sequence)

Recommended Name: Blood group Rh(D) polypeptide

Size: 417 amino acids; 45211 Da

Secondary accessions: Q02162 Q07618 Q16147 Q16235 Q16355 Q5VSK0 Q5XLS9 Q5XLT1 Q5XLT2 Q9NPK0

Q9UQ20 Q9UQ21 Q9UQ22 Q9UQ23

Alternative splicing: 6 isoforms: Q02161-1 Q02161-2 Q02161-3 Q02161-4 Q02161-5 Q02161-6

Explore the universe of human proteins at neXtProt for RHD: NX_Q02161

Explore proteomics data for RHD at MOPED

See RHD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (8 alternative transcripts):

NP_001121163.1 NP_001269796.1 NP_001269797.1 NP_001269798.1 NP_001269799.1 NP_001269800.1 NP_001269801.1 NP_057208.2

ENSEMBL proteins:

ENSP00000331871 ENSP00000413849 ENSP00000396420 ENSP00000350150 ENSP00000456966

ENSP00000339577 ENSP00000399640

RHD Human Recombinant Protein Products:

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	antibodies-online peptides for RHD

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CD: CD molecules

bloodgroup: Blood group antigens

2 InterPro protein domains:

IPR024041 NH4_transpt_AmtB-like_dom

IPR002229 RhesusRHD

Graphical View of Domain Structure for InterPro Entry Q02161

ProtoNet protein and cluster: Q02161

2 Blocks protein domains:

IPB002229 Rhesus blood group protein signature

IPB010256 Rh-like protein/ammonium transporter

UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161

Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily

Find genes that share domains with RHD About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: RHD_HUMAN, Q02161

Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the

erythrocyte membrane

Genatlas biochemistry entry for RHD:

Rhesus blood group,locus D,absent in the Caucasian RHD-negative phenotype

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008519	ammonium transmembrane transporter activity	IEA	--

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Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rhd):

hematopoietic system

homeostasis/metabolism

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Animal Models:
MGI mouse knock-out Rhd^tm1Goo for RHD

genOway: Develop your customized and physiologically relevant rodent model for RHD

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In Situ Assay
Products:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

RHD_HUMAN, Q02161: Membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
cytoskeleton	1
endoplasmic reticulum	1
extracellular	1
golgi apparatus	1
nucleus	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral component of plasma membrane	TAS	1438298
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	--	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for RHD
Interactions:

GeneGlobe Interaction Network for RHD

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RHD (Q02161³ ENSP00000331871⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAZ1B	Q9UIG0³, ENSP00000342434⁴	I2D: score=1 STRING: ENSP00000342434

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015696	ammonium transport	--	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for RHD

Selected Novoseek inferred chemical compound relationships for RHD gene (see all 37) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
methylammonium	72.3	1	16584906 (1)
amtb	58.9	2	16281947 (1), 16584906 (1)
ammonium	42.7	10	16564193 (2), 11358367 (1), 19807729 (1), 16574457 (1) (see all 8)
phenylhydrazine	39.8	2	2169881 (1), 7663379 (1)
polyacrylamide	30.3	5	8140503 (1), 10901146 (1), 11076426 (1), 9234582 (1) (see all 5)
dids	29	1	10077484 (1)
phospholipid	20.3	6	9506954 (1), 1858342 (1), 8663431 (1), 9088993 (1) (see all 6)
diamide	18.3	1	2168217 (1)
nh4cl	13.7	2	17712059 (2)
glyceraldehyde 3-phosphate	11.9	1	18721457 (1)

1 PharmGKB related drug/compound annotation for RHD gene About this table

Drug/compound	PharmGKB Annotation
clomifene

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RHD gene (9 alternative transcripts):

NM_001127691.2 NM_001282867.1 NM_001282868.1 NM_001282869.1 NM_001282870.1 NM_001282871.1 NM_001282872.1 NM_016124.4

NM_016225.3

Unigene Cluster for RHD:

Rh blood group, D antigen

Hs.449968 [show with all ESTs]

Unigene Representative Sequence: NM_016124

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000564398(uc010oep.2) ENST00000328664(uc001bjz.3 uc001bkc.3 uc009vrm.3 uc001bka.3 uc001bkb.3 uc009vrn.3 uc009vro.3 uc009vrp.3)

ENST00000454452 ENST00000423253 ENST00000417538 ENST00000357542 ENST00000568195

ENST00000342055 ENST00000423810

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Additional mRNA sequence:

AB018966.1 AB018967.1 AB018968.1 AB018969.1 AB037270.1 AB046420.1 AB049754.1 AF177938.1

AF187846.1 AF312679.1 AF510069.1 AF510070.1 AJ704215.2 AK297151.1 AM183924.3 AY449381.1

AY449382.1 AY449383.1 AY449384.1 AY449385.1 AY751491.1 AY751492.1 AY751493.1 AY751494.1

AY751495.1 AY751496.1 BC139922.1 DQ266353.1 DQ451878.1 EU557240.1 EU557241.1 EU661905.1

EU661906.1 EU661907.1 FN555129.1 FR745438.1 FR745439.1 FR745440.1 FR745441.1 HE657775.1

HQ711845.1 JF436967.1 JF436968.1 JN635688.1 JN635689.1 JQ065733.1 JQ424879.1 L08429.1

S57971.1 S70174.1 S73913.1 S78509.1 S82449.1 X63094.1 X63097.1 Z97026.1

11 DOTS entries:

DT.456144 DT.100706780 DT.121396511 DT.121396578 DT.121396677 DT.40295556 DT.75124277 DT.121396509

DT.95159897 DT.95260805 DT.95351321

Selected AceView cDNA sequences (see all 60):

AI282496 NM_016225 NM_016124 S73913 BV195681 BV204863 BV204876 AF510070

X63094 AF510069 BV204879 AY449381 AB046420 X63097 AB049754 AB018966

BV204864 L08429 BV204880 BV204870 AK024382 AJ704215 BV204873 BV202032

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RHD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

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RHD expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Blood (Hematopoietic System) fully expand to see all 8 entries
Erythroblasts Hematopoietic Bone Marrow
Bone Marrow CD105+ Cells
platelets

Bone (Muscoskeletal System) fully expand to see all 2 entries
bone marrow

Umbilical Cord (Extraembryonic Tissues)
umbilical cord reticulocytes

RHD Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RHD Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.449968

UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161

Tissue specificity: Restricted to tissues or cell lines expressing erythroid characters

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RHD gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rhd^{1 , 5}	Rh blood group, D antigen^{1, 5}	70.46(n)¹ 57.87(a)¹		4 (67.13 cM)⁵ 19746¹ NM_011270.3¹ NP_035400.3¹ 134864536⁵
chicken (Gallus gallus)	Aves	RHD¹	Rh blood group, D antigen	56.54(n) 43.29(a)		395121 NM_204467.1 NP_989798.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	41(a)	1 → many	GL343703.1(120008-136413)
tropical clawed frog (Xenopus tropicalis)	Amphibia	rhd¹	Rh blood group, D antigen	51.07(n) 37.62(a)		100038092 XM_002936599.2 XP_002936645.1
zebrafish (Danio rerio)	Actinopterygii	rhd⁶	Rh blood group, D antigen	34(a)	1 → many	13(46116954-46143214) ENSDARG00000002194
fruit fly (Drosophila melanogaster)	Insecta	Rh50⁶	Rh50	26(a)	1 → many	3L(4910368-4919321)
worm (Caenorhabditis elegans)	Secernentea	rhr-1⁶ rhr-2⁶	Protein RHR-2 (rhr-2) mRNA, complete cds	25(a) 25(a)	many ↔ many many ↔ many	V(5428160-5430431) WBGene00004358 V(11727898-11730160) WBGene00004359

ENSEMBL Gene Tree for RHD (if available)
TreeFam Gene Tree for RHD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RHD gene

RHCE¹ ² RHBG² RHAG² RHCG²

13 SIMAP similar genes for RHD using alignment to 247 protein entries: RHD_HUMAN (see all proteins):

RhDCw RhC RhD RhDTI RHD/RHCE RDH

RhIVb(J) RhCE RHCE RH50 RHAG RHBG

RHCG

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1 Pseudogenes.org Pseudogene for RHD
PGOHUM00000259458

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot

RHD_HUMAN, Q02161: RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40

blood group antigen is a polymorphism in position 110

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_035615⁴		A breast cancer sample⁴	--	see VAR_035615	2	S C	mis⁴		0	--	--	--	--
rs121912762^1,2	C,F	pathogenic¹	23865307(+)	`CACACT/CGTTCA`	4	/P /L	mis¹		2		NA EU	5159
rs121912763^1,2	C,F	pathogenic¹	23883883(+)	`TTATGT/GGCACA`	4	/G /V	mis¹		1		NA	4246
rs371335877^1,2	C	--	23851101(+)	`CCCCAA/CCCATC`	2	--	us2k¹		0	--	--	--	--
rs188017669^1,2		--	23851124(+)	`ACCCCA/GGTCCA`	2	--	us2k¹		0	--	--	--	--
rs144600207^1,2		--	23851128(+)	`CGGTCA/CATGGA`	2	--	us2k¹		0	--	--	--	--
rs148494337^1,2		--	23851145(+)	`GTCTTC/TTACAA`	2	--	us2k¹		0	--	--	--	--
rs114632238^1,2	F	--	23851148(+)	`TTTTAC/GAAAAC`	2	--	us2k¹		1		WA	118
rs1750381^1,2	C	--	23851174(+)	`aaaagC/Gttggg`	2	--	us2k¹		0	--	--	--	--
rs76143255^1,2	F	--	23851218(+)	`ACACCG/CAGGTC`	2	--	us2k¹		1		NA	4

HapMap Linkage Disequilibrium report for RHD (25598884 - 25656936 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for RHD (see all 30): About this table

Variant ID	Type	Subtype	PubMed ID
dgv32e199	CNV	Deletion	23128226
esv2421857	CNV	Deletion	20811451
esv2677880	CNV	Deletion	23128226
esv2656832	CNV	Deletion	23128226
esv2745608	CNV	Deletion	23290073
nsv821372	CNV	Deletion	20802225
nsv7409	CNV	Insertion	18451855
nsv7298	CNV	Loss	18451855
nsv232	CNV	Loss	15895083
nsv498667	CNV	Loss	21111241

Human Gene Mutation Database (HGMD): RHD
Locus Specific Mutation Databases (LSDB): RHD

Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RHD

DNA2.0 Custom Variant and Variant Library Synthesis for RHD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 111680 OMIM disorders: --

11 diseases for RHD:
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acanthocytosis uremia chorea-acanthocytosis hereditary elliptocytosis

typhoid fever hereditary spherocytosis rh isoimmunization anemia, hemolytic, rh-null, regulator type

fundus albipunctatus malaria kernicterus

5 inferred disease relationships from the University of Copenhagen DISEASES database for RHD:

Rhabdomyosarcoma Rh isoimmunization Fundus albipunctatus Anemia

Kernicterus

Find genes that share disorders with RHD About GenesLikeMe

Selected Novoseek inferred disease relationships for RHD gene (see all 35) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
spherocytosis hereditary	85.3	20	8140503 (2), 1295777 (1), 9844481 (1), 10766130 (1) (see all 19)
hemolytic disease	75	8	7856682 (2), 19953292 (1), 11288127 (1), 14607035 (1) (see all 6)
elliptocytosis hereditary	73.4	4	14695625 (1), 17414207 (1), 10037687 (1), 16985305 (1)
spherocytosis	73.2	1	12719424 (1)
anemia dyserythropoietic congenital	73.2	4	18166993 (1), 14533796 (1)
anemia hemolytic	62.2	4	10766130 (1), 15961204 (1), 11102985 (1), 9235914 (1)
rh hemolytic disease	58.3	7	16396876 (1), 15961204 (1)
protein deficiency	46.7	3	12828006 (1), 14636652 (1), 15279669 (1)
hemolysis	45	2	9504940 (1), 19704946 (1)
anemia	30.2	5	9504940 (1), 18166993 (1), 19508687 (1), 14533796 (1)

Genetic Association Database (GAD): RHD
Human Genome Epidemiology (HuGE) Navigator: RHD (65 documents)

Export disorders for RHD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RHD gene, integrated from 10 sources (see all 352):
(articles sorted by number of sources associating them with RHD)

Utopia: connect your pdf to the dynamic
world of online information

RHD gene polymorphism among RhD-negative Han Chinese. (PubMed id 14570619)^{1, 4, 9} Xu Q....Si G. (Chin. Med. J. 2003)
Prenatal RHD gene determination and dosage analysis by PCR: clinical evaluation. (PubMed id 11288127)^{1, 4, 9} Chan F.Y....Hyland C.A. (Prenat. Diagn. 2001)
Rh(D) antigen expression and isolation of a new Rh(D) cDNA isoform in human erythroleukemic K562 cells. (PubMed id 8080999)^{1, 2, 9} Suyama K.... Goldstein J. (Blood 1994)
Molecular cloning and primary structure of the human blood group RhD polypeptide. (PubMed id 1438298)^{1, 2, 9} le van Kim C.... Colin Y. (Proc. Natl. Acad. Sci. U.S.A. 1992)
Non-invasive foetal RHD genotyping via real-time PCR of foetal DNA from Chinese RhD-negative maternal plasma. (PubMed id 19545247)^{1, 4} Wang X.D....He Z.M. (Eur. J. Clin. Invest. 2009)
[RHD gene polymorphism of RhD negative individuals in population of Fujian province]. (PubMed id 18426681)^{1, 4} Zhuo C.S....Wang C.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
Prevalence of RHD 1227A and hybrid Rhesus box in the general Chinese population. (PubMed id 17196520)^{1, 4} Yang Y.F....Lin T.M. (Transl Res 2007)
[RHD 1227A allele frequency among Rh negative population and random population]. (PubMed id 17204201)^{1, 4} Wu J.J....Yan L.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006)
ABO and Rh D polymorphism among Tibetans in India. (PubMed id 17036929)^{1, 4} Tripathy V....Gupta R. (Hum. Biol. 2006)
Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele. (PubMed id 16510313)^{1, 2} Shao C.P.... Zhou Y.Y. (Transfus. Apher. Sci. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6007	HGNC: 10009	AceView: RHD	Ensembl:ENSG00000187010	euGenes: HUgn6007
ECgene: RHD	H-InvDB: RHD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RHD	Pharmacogenomics, SNPs, Pathways
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh
GeneReviews	http://www.ncbi.nlm.nih.gov/books/NBK1116/?term=RHD[genesymbol]

Intellectual Property for RHD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RHD gene:
Search GeneIP for patents involving RHD

GeneCards and IP:
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RHD Gene

Rh Blood Group, D Antigen

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RHD (Gene Symbol)
Rh Blood Group, D Antigen
RH
Rh Polypeptide 2
Rhesus D Antigen
RHXIII
Rhesus Blood Group, D Antigen
CD240D
DIIIc
RH30
RHCED
RHDVA(TT)
RHDel
RHPII
Rh4
RhDCw
RhII
RhK562-II
RhPI
Blood Group Rh(D) Polypeptide
D Antigen (DCS)
Rh Blood Group Antigen Evans
Rh Blood Group, D Anitgen
Rhesus Blood Group D Antigen Allele DIII Type 7
Rhesus System D Polypeptide
RhPII
CD240D Antigen

Cirrhosis
Hemolytic disease
HYPERTENSION ARTERIAL
Malaria
Anemia Hemolytic
Leukemia
Diabetes Mellitus
Purpura Thrombocytopenic Idiopathic
Jaundice Neonatal
Schizophrenia
AIDS
Anemia Dyserythropoietic Congenital
beta-Thalassemia
Spherocytosis
Protein Deficiency
Hemolysis
Spherocytosis Hereditary
Hypotension
Nephrolithiasis
Rh hemolytic disease
Uremia
Bleeding
SICKLE CELL DISEASE
immunodeficiency
Hyperhomocysteinemia
Jaundice Obstructive
Hepatitis B
Anemia
MYELOMA
Polio
Elliptocytosis Hereditary
Cardiovascular Diseases
Tumors
Typhoid Fever
Renal Failure Chronic

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RHD Gene

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