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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHD Gene

protein-coding   GIFtS: 57
GCID: GC01P025599

Rh Blood Group, D Antigen

(Previous names: Rhesus blood group, D antigen, Rh blood group, D antigen)
(Previous symbol: RH)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rh Blood Group, D Antigen1 2     Rh42
RH1 2     RhDCw2
Rh Polypeptide 22 3     RhII2
Rhesus D Antigen2 3     RhK562-II2
RHXIII2 3     RhPI2
Rhesus Blood Group, D Antigen1     Blood Group Rh(D) Polypeptide2
CD240D2     D Antigen (DCS)2
DIIIc2     Rh Blood Group Antigen Evans2
RH302     Rh Blood Group, D Anitgen2
RHCED2     Rhesus Blood Group D Antigen Allele DIII Type 72
RHDVA(TT)2     Rhesus System D Polypeptide2
RHDel2     RhPII3
RHPII2     CD240D Antigen3

External Ids:    HGNC: 100091   Entrez Gene: 60072   Ensembl: ENSG000001870107   OMIM: 1116805   UniProtKB: Q021613   

Export aliases for RHD gene to outside databases

Previous GC identifers: GC01M025154 GC01M024859 GC01M024598 GC01P025154 GC01P025344 GC01P025471 GC01P023853


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHD Gene:
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is
also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense
mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes
both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a
cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the
presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RHD Gene: 
RHD (Rh blood group, D antigen) is a protein-coding gene. Diseases associated with RHD include skeletal muscle neoplasm, and uremia. GO annotations related to this gene include ammonium transmembrane transporter activity. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161
Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the
erythrocyte membrane

Gene Wiki entry for RHD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHD gene promoter:
         SRF   SRF (504 AA)   Chx10   MyoD   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHD promoter sequence
   Search SABiosciences Chromatin IP Primers for RHD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

RHD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHD gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P025599:  view genomic region     (about GC identifiers)

Start:
25,598,884 bp from pter      End:
25,656,936 bp from pter
Size:
58,053 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161 (See protein sequence)
Recommended Name: Blood group Rh(D) polypeptide  
Size: 417 amino acids; 45211 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q02162 Q07618 Q16147 Q16235 Q16355 Q5VSK0 Q9NPK0 Q9UQ20 Q9UQ21 Q9UQ22
Q9UQ23
Alternative splicing: 3 isoforms:  Q02161-1   Q02161-2   Q02161-3   

Explore the universe of human proteins at neXtProt for RHD: NX_Q02161

Explore proteomics data for RHD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02161

  • RHD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHD Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001121163.1  NP_001269796.1  NP_001269797.1  NP_001269798.1  NP_001269799.1  NP_001269800.1  NP_001269801.1  NP_057208.2  

    ENSEMBL proteins: 
     ENSP00000331871   ENSP00000413849   ENSP00000396420   ENSP00000350150   ENSP00000456966  
     ENSP00000339577   ENSP00000399640  

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    Cloud-Clone Corp. Proteins for RHD 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS1438298
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    RHD for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for RHD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    bloodgroup: Blood group antigens

    2 InterPro protein domains:
     IPR024041 NH4_transpt_AmtB-like_dom
     IPR002229 RhesusRHD

    Graphical View of Domain Structure for InterPro Entry Q02161

    ProtoNet protein and cluster: Q02161

    2 Blocks protein domains:
    IPB002229 Rhesus blood group protein signature
    IPB010256 Rh-like protein/ammonium transporter


    UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161
    Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily


    RHD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHD_HUMAN, Q02161
    Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the
    erythrocyte membrane

         Genatlas biochemistry entry for RHD:
    Rhesus blood group,locus D,absent in the Caucasian RHD-negative phenotype

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008519ammonium transmembrane transporter activity IEA--
         
    RHD for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhd):
     hematopoietic system  homeostasis/metabolism 

    RHD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rhdtm1Goo for RHD

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHD 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHD

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RHD (Q021613 ENSP000003318714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAZ1BQ9UIG03, ENSP000003424344I2D: score=1 STRING: ENSP00000342434
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015696ammonium transport ----

    RHD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHD

    10/37 Novoseek inferred chemical compound relationships for RHD gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylammonium 72.3 1 16584906 (1)
    amtb 58.9 2 16281947 (1), 16584906 (1)
    ammonium 42.7 10 16564193 (2), 11358367 (1), 19807729 (1), 16574457 (1) (see all 8)
    phenylhydrazine 39.8 2 2169881 (1), 7663379 (1)
    polyacrylamide 30.3 5 8140503 (1), 10901146 (1), 11076426 (1), 9234582 (1) (see all 5)
    dids 29 1 10077484 (1)
    phospholipid 20.3 6 9506954 (1), 1858342 (1), 8663431 (1), 9088993 (1) (see all 6)
    diamide 18.3 1 2168217 (1)
    nh4cl 13.7 2 17712059 (2)
    glyceraldehyde 3-phosphate 11.9 1 18721457 (1)

    1 PharmGKB related drug/compound annotation for RHD gene    About this table
    Drug/compound PharmGKB Annotation
    clomifene

    Search CenterWatch for drugs/clinical trials and news about RHD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHD gene (9 alternative transcripts): 
    NM_001127691.2  NM_001282867.1  NM_001282868.1  NM_001282869.1  NM_001282870.1  NM_001282871.1  NM_001282872.1  NM_016124.4  
    NM_016225.3  

    Unigene Cluster for RHD:

    Rh blood group, D antigen
    Hs.449968  [show with all ESTs]
    Unigene Representative Sequence: NM_016124
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564398(uc010oep.2) ENST00000328664(uc001bjz.3 uc001bkc.3 uc009vrm.3 uc001bka.3 uc001bkb.3 uc009vrn.3 uc009vro.3 uc009vrp.3)
    ENST00000454452 ENST00000423253 ENST00000417538 ENST00000357542 ENST00000568195
    ENST00000342055 ENST00000423810
    miRNA
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    Additional mRNA sequence: 

    AB018966.1 AB018967.1 AB018968.1 AB018969.1 AB037270.1 AB046420.1 AB049754.1 AF177938.1 
    AF187846.1 AF312679.1 AF510069.1 AF510070.1 AJ704215.2 AK297151.1 AM183924.3 AY449381.1 
    AY449382.1 AY449383.1 AY449384.1 AY449385.1 AY751491.1 AY751492.1 AY751493.1 AY751494.1 
    AY751495.1 AY751496.1 BC139922.1 DQ266353.1 DQ451878.1 EU557240.1 EU557241.1 EU661905.1 
    EU661906.1 EU661907.1 FN555129.1 FR745438.1 FR745439.1 FR745440.1 FR745441.1 HE657775.1 
    HQ711845.1 JF436967.1 JF436968.1 JN635688.1 JN635689.1 JQ065733.1 JQ424879.1 L08429.1 
    S57971.1 S70174.1 S73913.1 S78509.1 S82449.1 X63094.1 X63097.1 Z97026.1 

    11 DOTS entries:

    DT.456144  DT.100706780  DT.121396511  DT.121396578  DT.121396677  DT.40295556  DT.75124277  DT.121396509 
    DT.95159897  DT.95260805  DT.95351321 

    24/60 AceView cDNA sequences (see all 60):

    NM_016225 AI282496 NM_016124 S73913 AU140652 AF510070 AB018968 X63094 
    AB049754 BV204878 BV202032 BV204864 AB046420 AB018967 BV195681 BV204872 
    AF187846 BV204861 AB018969 L08429 AA836138 AJ704215 BU662207 BU664659 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RHD Expression
    About this image


    See RHD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHD

    SOURCE GeneReport for Unigene cluster: Hs.449968

    UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161
    Tissue specificity: Restricted to tissues or cell lines expressing erythroid characters

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RHD gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhd1 , 5 Rh blood group, D antigen1, 5 70.46(n)1
    57.87(a)1
      4 (67.13 cM)5
    197461  NM_011270.31  NP_035400.31 
     1348645365 
    chicken
    (Gallus gallus)
    Aves RHD1 Rh blood group, D antigen 55.86(n)
    42.71(a)
      395121  NM_204467.1  NP_989798.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    41(a)
    25(a)
    1 ↔ many
    possible ortholog
    GL343703.1(120008-136413)
    4(155518610-155520073)
    zebrafish
    (Danio rerio)
    Actinopterygii rhd6
    rh506
    Rh50-like protein
    33(a)
    27(a)
    1 ↔ many
    possible ortholog
    13(46116954-46143214)
    8(38371549-38375675)
    fruit fly
    (Drosophila melanogaster)
    Insecta Rh506
    Rh50
    26(a)
    1 → many
    3L(4910368-4919321)
    worm
    (Caenorhabditis elegans)
    Secernentea rhr-26
    rhr-16
    Protein RHR-1
    24(a)
    24(a)
    many ↔ many
    many ↔ many
    V(11727898-11730160)
    V(5428160-5430431)


    ENSEMBL Gene Tree for RHD (if available)
    TreeFam Gene Tree for RHD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHD gene
    RHCE1 2  RHBG2  RHAG2  RHCG2  
    13 SIMAP similar genes for RHD using alignment to 235 protein entries:     RHD_HUMAN (see all proteins):
    RhDCw    RhC    RhD    RhDTI    RHD/RHCE    RDH
    RhIVb(J)    RhCE    RHCE    RH50    RHAG    RHBG
    RHCG

    RHD for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RHD
    PGOHUM00000259458


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161
    Polymorphism: RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40
    blood group antigen is a polymorphism in position 110


    10/1429 SNPs in RHD are shown (see all 1429)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356154
    A breast cancer sample4--see VAR_0356152 S C mis40--------
    rs1219127621,2
    C,Fpathogenic123865307(+) CACACT/CGTTCA 4 /P /L mis12Minor allele frequency- C:0.00NA EU 5159
    rs1219127631,2
    C,Fpathogenic123883883(+) TTATGT/GGCACA 4 /G /V mis11Minor allele frequency- G:0.00NA 4246
    VAR_0344574
    ----see VAR_0344572 T R mis40--------
    VAR_0344554
    ----see VAR_0344552 W C mis40--------
    VAR_0069194
    ----see VAR_0069192 L P mis40--------
    rs3713358771,2
    C--23851101(+) CCCCAA/CCCATC 2 -- us2k10--------
    rs1880176691,2
    --23851124(+) ACCCCA/GGTCCA 2 -- us2k10--------
    rs1446002071,2
    --23851128(+) CGGTCA/CATGGA 2 -- us2k10--------
    rs1484943371,2
    --23851145(+) GTCTTC/TTACAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHD (25598884 - 25656936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/30 variations for RHD (see all 30):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv32e199CNV Deletion23128226
    esv2421857CNV Deletion20811451
    esv2677880CNV Deletion23128226
    esv2656832CNV Deletion23128226
    esv2745608CNV Deletion23290073
    nsv821372CNV Deletion20802225
    nsv7409CNV Insertion18451855
    nsv7298CNV Loss18451855
    nsv232CNV Loss15895083
    nsv498667CNV Loss21111241


    Human Gene Mutation Database (HGMD): RHD

    Locus Specific Mutation Databases (LSDB): RHD
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RHD
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 111680    OMIM disorders: --

    20/46 diseases for RHD (see all 46):    About MalaCards
    skeletal muscle neoplasm    uremia    rh isoimmunization    jaundice
    typhoid fever    hereditary elliptocytosis    chorea-acanthocytosis    acanthocytosis
    poliomyelitis    sickle cell disease    fundus albipunctatus    hiv/aids
    hyperhomocysteinemia    nephrolithiasis    kernicterus    neonatal jaundice
    obstructive jaundice    beta thalassemia    protein s deficiency    hydrops fetalis

    5 diseases from the University of Copenhagen DISEASES database for RHD:
    Rhabdomyosarcoma     Rh isoimmunization     Fundus albipunctatus     Anemia
    Kernicterus

    RHD for disorders           About GeneDecksing

    10/35 Novoseek inferred disease relationships for RHD gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spherocytosis hereditary 85.3 20 8140503 (2), 1295777 (1), 9844481 (1), 10766130 (1) (see all 19)
    hemolytic disease 75 8 7856682 (2), 19953292 (1), 11288127 (1), 14607035 (1) (see all 6)
    elliptocytosis hereditary 73.4 4 14695625 (1), 17414207 (1), 10037687 (1), 16985305 (1)
    spherocytosis 73.2 1 12719424 (1)
    anemia dyserythropoietic congenital 73.2 4 18166993 (1), 14533796 (1)
    anemia hemolytic 62.2 4 10766130 (1), 15961204 (1), 11102985 (1), 9235914 (1)
    rh hemolytic disease 58.3 7 16396876 (1), 15961204 (1)
    protein deficiency 46.7 3 12828006 (1), 14636652 (1), 15279669 (1)
    hemolysis 45 2 9504940 (1), 19704946 (1)
    anemia 30.2 5 9504940 (1), 18166993 (1), 19508687 (1), 14533796 (1)

    Genetic Association Database (GAD): RHD
    Human Genome Epidemiology (HuGE) Navigator: RHD (65 documents)

    Export disorders for RHD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHD gene, integrated from 9 sources (see all 341):
    (articles sorted by number of sources associating them with RHD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RHD gene polymorphism among RhD-negative Han Chinese. (PubMed id 14570619)1, 4, 9 Xu Q....Si G. (2003)
    2. Prenatal RHD gene determination and dosage analysis by PCR: clinical evaluation. (PubMed id 11288127)1, 4, 9 Chan F.Y....Hyland C.A. (2001)
    3. Rh(D) antigen expression and isolation of a new Rh(D) cDNA isoform in human erythroleukemic K562 cells. (PubMed id 8080999)1, 2, 9 Suyama K.... Goldstein J. (1994)
    4. Molecular cloning and primary structure of the human blood group RhD polypeptide. (PubMed id 1438298)1, 2, 9 le van Kim C.... Colin Y. (1992)
    5. Non-invasive foetal RHD genotyping via real-time PCR of foetal DNA from Chinese RhD-negative maternal plasma. (PubMed id 19545247)1, 4 Wang X.D....He Z.M. (2009)
    6. [RHD gene polymorphism of RhD negative individuals in population of Fujian province] (PubMed id 18426681)1, 4 Zhuo C.S....Wang C.Q. (2008)
    7. Prevalence of RHD 1227A and hybrid Rhesus box in the general Chinese population. (PubMed id 17196520)1, 4 Yang Y.F....Lin T.M. (2007)
    8. [RHD 1227A allele frequency among Rh negative population and random population] (PubMed id 17204201)1, 4 Wu J.J....Yan L.X. (2006)
    9. ABO and Rh D polymorphism among Tibetans in India. (PubMed id 17036929)1, 4 Tripathy V....Gupta R. (2006)
    10. Random survey for RHD alleles among D+ European persons. (PubMed id 15987365)1, 4 Chen Q. and Flegel W.A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6007 HGNC: 10009 AceView: RHD Ensembl:ENSG00000187010 euGenes: HUgn6007
    ECgene: RHD H-InvDB: RHD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHD Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RHD

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHD gene:
    Search GeneIP for patents involving RHD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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