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RHD Gene

protein-coding   GIFtS: 56
GCID: GC01P025599

Rh Blood Group, D Antigen

(Previous names: Rhesus blood group, D antigen, Rh blood group, D antigen)
(Previous symbol: RH)
Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rh Blood Group, D Antigen1 2     Rh42
RH1 2     RhDCw2
Rh Polypeptide 22 3     RhII2
Rhesus D Antigen2 3     RhK562-II2
RHXIII2 3     RhPI2
Rhesus Blood Group, D Antigen1     Blood Group Rh(D) Polypeptide2
CD240D2     D Antigen (DCS)2
DIIIc2     Rh Blood Group Antigen Evans2
RH302     Rh Blood Group, D Anitgen2
RHCED2     Rhesus Blood Group D Antigen Allele DIII Type 72
RHDVA(TT)2     Rhesus System D Polypeptide2
RHDel2     RhPII3
RHPII2     CD240D Antigen3

External Ids:    HGNC: 100091   Entrez Gene: 60072   Ensembl: ENSG000001870107   OMIM: 1116805   UniProtKB: Q021613   

Export aliases for RHD gene to outside databases

Previous GC identifers: GC01M025154 GC01M024859 GC01M024598 GC01P025154 GC01P025344 GC01P025471 GC01P023853


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHD Gene:
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is
also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense
mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes
both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a
cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the
presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RHD Gene:
RHD (Rh blood group, D antigen) is a protein-coding gene. Diseases associated with RHD include uremia, and skeletal muscle neoplasm. GO annotations related to this gene include ammonium transmembrane transporter activity. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161
Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the
erythrocyte membrane

Gene Wiki entry for RHD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHD gene promoter:
         SRF   SRF (504 AA)   Chx10   MyoD   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHD promoter sequence
   Search Chromatin IP Primers for RHD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

RHD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHD gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P025599:  view genomic region     (about GC identifiers)

Start:
25,598,884 bp from pter      End:
25,656,936 bp from pter
Size:
58,053 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161 (See protein sequence)
Recommended Name: Blood group Rh(D) polypeptide  
Size: 417 amino acids; 45211 Da
Secondary accessions: Q02162 Q07618 Q16147 Q16235 Q16355 Q5VSK0 Q5XLS9 Q5XLT1 Q5XLT2 Q9NPK0
Q9UQ20 Q9UQ21 Q9UQ22 Q9UQ23
Alternative splicing: 6 isoforms:  Q02161-1   Q02161-2   Q02161-3   Q02161-4   Q02161-5   Q02161-6   

Explore the universe of human proteins at neXtProt for RHD: NX_Q02161

Explore proteomics data for RHD at MOPED


See RHD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (8 alternative transcripts): 
NP_001121163.1  NP_001269796.1  NP_001269797.1  NP_001269798.1  NP_001269799.1  NP_001269800.1  NP_001269801.1  NP_057208.2  

ENSEMBL proteins: 
 ENSP00000331871   ENSP00000413849   ENSP00000396420   ENSP00000350150   ENSP00000456966  
 ENSP00000339577   ENSP00000399640  

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Cloud-Clone Corp. CLIAs for RHD


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CD: CD molecules
bloodgroup: Blood group antigens

2 InterPro protein domains:
 IPR024041 NH4_transpt_AmtB-like_dom
 IPR002229 RhesusRHD

Graphical View of Domain Structure for InterPro Entry Q02161

ProtoNet protein and cluster: Q02161

2 Blocks protein domains:
IPB002229 Rhesus blood group protein signature
IPB010256 Rh-like protein/ammonium transporter


UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161
Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily


RHD for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RHD_HUMAN, Q02161
Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the
erythrocyte membrane

     Genatlas biochemistry entry for RHD:
Rhesus blood group,locus D,absent in the Caucasian RHD-negative phenotype

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008519ammonium transmembrane transporter activity IEA--
     
RHD for ontologies           About GeneDecksing


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rhd):
 hematopoietic system  homeostasis/metabolism 

RHD for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Rhdtm1Goo for RHD

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHD
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHD

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHD
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHD

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Predesigned siRNA for gene silencing in human, mouse, rat RHD

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RHD_HUMAN, Q02161: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane4
cytoskeleton1
endoplasmic reticulum1
extracellular1
golgi apparatus1
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005887integral component of plasma membrane TAS1438298
GO:0016020membrane ----
GO:0016021integral component of membrane ----

RHD for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHD
Interactions:

    GeneGlobe Interaction Network for RHD

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RHD (Q021613 ENSP000003318714) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
BAZ1BQ9UIG03, ENSP000003424344I2D: score=1 STRING: ENSP00000342434
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015696ammonium transport ----

RHD for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RHD

Selected Novoseek inferred chemical compound relationships for RHD gene (see all 37)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
methylammonium 72.3 1 16584906 (1)
amtb 58.9 2 16281947 (1), 16584906 (1)
ammonium 42.7 10 16564193 (2), 11358367 (1), 19807729 (1), 16574457 (1) (see all 8)
phenylhydrazine 39.8 2 2169881 (1), 7663379 (1)
polyacrylamide 30.3 5 8140503 (1), 10901146 (1), 11076426 (1), 9234582 (1) (see all 5)
dids 29 1 10077484 (1)
phospholipid 20.3 6 9506954 (1), 1858342 (1), 8663431 (1), 9088993 (1) (see all 6)
diamide 18.3 1 2168217 (1)
nh4cl 13.7 2 17712059 (2)
glyceraldehyde 3-phosphate 11.9 1 18721457 (1)

1 PharmGKB related drug/compound annotation for RHD gene    About this table
Drug/compound PharmGKB Annotation
clomifene



RHD for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RHD gene (9 alternative transcripts): 
NM_001127691.2  NM_001282867.1  NM_001282868.1  NM_001282869.1  NM_001282870.1  NM_001282871.1  NM_001282872.1  NM_016124.4  
NM_016225.3  

Unigene Cluster for RHD:

Rh blood group, D antigen
Hs.449968  [show with all ESTs]
Unigene Representative Sequence: NM_016124
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000564398(uc010oep.2) ENST00000328664(uc001bjz.3 uc001bkc.3 uc009vrm.3 uc001bka.3 uc001bkb.3 uc009vrn.3 uc009vro.3 uc009vrp.3)
ENST00000454452 ENST00000423253 ENST00000417538 ENST00000357542 ENST00000568195
ENST00000342055 ENST00000423810

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat RHD
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GenScript: all cDNA clones in your preferred vector (see all 2): RHD (NM_016124)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHD
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHD
Primer
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OriGene qPCR primer pairs and template standards for RHD
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHD
  QuantiTect SYBR Green Assays in human, mouse, rat RHD
  QuantiFast Probe-based Assays in human, mouse, rat RHD

Additional mRNA sequence: 

AB018966.1 AB018967.1 AB018968.1 AB018969.1 AB037270.1 AB046420.1 AB049754.1 AF177938.1 
AF187846.1 AF312679.1 AF510069.1 AF510070.1 AJ704215.2 AK297151.1 AM183924.3 AY449381.1 
AY449382.1 AY449383.1 AY449384.1 AY449385.1 AY751491.1 AY751492.1 AY751493.1 AY751494.1 
AY751495.1 AY751496.1 BC139922.1 DQ266353.1 DQ451878.1 EU557240.1 EU557241.1 EU661905.1 
EU661906.1 EU661907.1 FN555129.1 FR745438.1 FR745439.1 FR745440.1 FR745441.1 HE657775.1 
HQ711845.1 JF436967.1 JF436968.1 JN635688.1 JN635689.1 JQ065733.1 JQ424879.1 L08429.1 
S57971.1 S70174.1 S73913.1 S78509.1 S82449.1 X63094.1 X63097.1 Z97026.1 

11 DOTS entries:

DT.456144  DT.100706780  DT.121396511  DT.121396578  DT.121396677  DT.40295556  DT.75124277  DT.121396509 
DT.95159897  DT.95260805  DT.95351321 

Selected AceView cDNA sequences (see all 60):

AI282496 NM_016225 NM_016124 S73913 BV195681 BV204863 BV204876 AF510070 
X63094 AF510069 BV204879 AY449381 AB046420 X63097 AB049754 AB018966 
BV204864 L08429 BV204880 BV204870 AK024382 AJ704215 BV204873 BV202032 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RHD expression in normal human tissues (normalized intensities)      RHD embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RHD Expression
About this image


RHD expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 8 entries
         Erythroblasts Hematopoietic Bone Marrow
         Bone Marrow CD105+ Cells   
         platelets   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         bone marrow   
 
 Umbilical Cord (Extraembryonic Tissues)
         umbilical cord reticulocytes   
RHD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RHD Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.449968

UniProtKB/Swiss-Prot: RHD_HUMAN, Q02161
Tissue specificity: Restricted to tissues or cell lines expressing erythroid characters

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RHD gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rhd1 , 5 Rh blood group, D antigen1, 5 70.46(n)1
57.87(a)1
  4 (67.13 cM)5
197461  NM_011270.31  NP_035400.31 
 1348645365 
chicken
(Gallus gallus)
Aves RHD1 Rh blood group, D antigen 56.54(n)
43.29(a)
  395121  NM_204467.1  NP_989798.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
41(a)
1 → many
GL343703.1(120008-136413)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rhd1 Rh blood group, D antigen 51.07(n)
37.62(a)
  100038092  XM_002936599.2  XP_002936645.1 
zebrafish
(Danio rerio)
Actinopterygii rhd6
Rh blood group, D antigen
34(a)
1 → many
13(46116954-46143214) ENSDARG00000002194
fruit fly
(Drosophila melanogaster)
Insecta Rh506
Rh50
26(a)
1 → many
3L(4910368-4919321)
worm
(Caenorhabditis elegans)
Secernentea rhr-16
rhr-26
Protein RHR-2 (rhr-2) mRNA, complete cds
25(a)
25(a)
many ↔ many
many ↔ many
V(5428160-5430431) WBGene00004358
V(11727898-11730160) WBGene00004359


ENSEMBL Gene Tree for RHD (if available)
TreeFam Gene Tree for RHD (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RHD gene
RHCE1 2  RHBG2  RHAG2  RHCG2  
13 SIMAP similar genes for RHD using alignment to 247 protein entries:     RHD_HUMAN (see all proteins):
RhDCw    RhC    RhD    RhDTI    RHD/RHCE    RDH
RhIVb(J)    RhCE    RHCE    RH50    RHAG    RHBG
RHCG

RHD for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for RHD
PGOHUM00000259458


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
RHD_HUMAN, Q02161: RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40
blood group antigen is a polymorphism in position 110


Selected SNPs for RHD (see all 1429)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0356154
A breast cancer sample4--see VAR_0356152 S C mis40--------
rs1219127621,2
C,Fpathogenic123865307(+) CACACT/CGTTCA 4 /P /L mis12Minor allele frequency- C:0.00NA EU 5159
rs1219127631,2
C,Fpathogenic123883883(+) TTATGT/GGCACA 4 /G /V mis11Minor allele frequency- G:0.00NA 4246
rs3713358771,2
C--23851101(+) CCCCAA/CCCATC 2 -- us2k10--------
rs1880176691,2
--23851124(+) ACCCCA/GGTCCA 2 -- us2k10--------
rs1446002071,2
--23851128(+) CGGTCA/CATGGA 2 -- us2k10--------
rs1484943371,2
--23851145(+) GTCTTC/TTACAA 2 -- us2k10--------
rs1146322381,2
F--23851148(+) TTTTAC/GAAAAC 2 -- us2k11Minor allele frequency- G:0.04WA 118
rs17503811,2
C--23851174(+) aaaagC/Gttggg 2 -- us2k10--------
rs761432551,2
F--23851218(+) ACACCG/CAGGTC 2 -- us2k11Minor allele frequency- C:0.50NA 4

HapMap Linkage Disequilibrium report for RHD (25598884 - 25656936 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RHD (see all 30):    About this table    
Variant IDTypeSubtypePubMed ID
dgv32e199CNV Deletion23128226
esv2421857CNV Deletion20811451
esv2677880CNV Deletion23128226
esv2656832CNV Deletion23128226
esv2745608CNV Deletion23290073
nsv821372CNV Deletion20802225
nsv7409CNV Insertion18451855
nsv7298CNV Loss18451855
nsv232CNV Loss15895083
nsv498667CNV Loss21111241

Human Gene Mutation Database (HGMD): RHD
Locus Specific Mutation Databases (LSDB): RHD

Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 111680    OMIM disorders: --

Selected diseases for RHD (see all 49):    About MalaCards
uremia    skeletal muscle neoplasm    rh isoimmunization    anemia, hemolytic, rh-null, regulator type
typhoid fever    hereditary spherocytosis    chorea-acanthocytosis    acanthocytosis
hereditary elliptocytosis    poliomyelitis    sickle cell disease    chorea
neonatal jaundice    nephrolithiasis    hyperhomocysteinemia    fundus albipunctatus
kernicterus    hydrops fetalis    beta thalassemia    obstructive jaundice

5 diseases from the University of Copenhagen DISEASES database for RHD:
Rhabdomyosarcoma     Rh isoimmunization     Fundus albipunctatus     Anemia
Kernicterus

RHD for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for RHD gene (see all 35)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
spherocytosis hereditary 85.3 20 8140503 (2), 1295777 (1), 9844481 (1), 10766130 (1) (see all 19)
hemolytic disease 75 8 7856682 (2), 19953292 (1), 11288127 (1), 14607035 (1) (see all 6)
elliptocytosis hereditary 73.4 4 14695625 (1), 17414207 (1), 10037687 (1), 16985305 (1)
spherocytosis 73.2 1 12719424 (1)
anemia dyserythropoietic congenital 73.2 4 18166993 (1), 14533796 (1)
anemia hemolytic 62.2 4 10766130 (1), 15961204 (1), 11102985 (1), 9235914 (1)
rh hemolytic disease 58.3 7 16396876 (1), 15961204 (1)
protein deficiency 46.7 3 12828006 (1), 14636652 (1), 15279669 (1)
hemolysis 45 2 9504940 (1), 19704946 (1)
anemia 30.2 5 9504940 (1), 18166993 (1), 19508687 (1), 14533796 (1)

Genetic Association Database (GAD): RHD
Human Genome Epidemiology (HuGE) Navigator: RHD (65 documents)

Export disorders for RHD gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RHD gene, integrated from 10 sources (see all 352):
(articles sorted by number of sources associating them with RHD)
    Utopia: connect your pdf to the dynamic
world of online information

  1. RHD gene polymorphism among RhD-negative Han Chinese. (PubMed id 14570619)1, 4, 9 Xu Q....Si G. (Chin. Med. J. 2003)
  2. Prenatal RHD gene determination and dosage analysis by PCR: clinical evaluation. (PubMed id 11288127)1, 4, 9 Chan F.Y....Hyland C.A. (Prenat. Diagn. 2001)
  3. Rh(D) antigen expression and isolation of a new Rh(D) cDNA isoform in human erythroleukemic K562 cells. (PubMed id 8080999)1, 2, 9 Suyama K.... Goldstein J. (Blood 1994)
  4. Molecular cloning and primary structure of the human blood group RhD polypeptide. (PubMed id 1438298)1, 2, 9 le van Kim C.... Colin Y. (Proc. Natl. Acad. Sci. U.S.A. 1992)
  5. Non-invasive foetal RHD genotyping via real-time PCR of foetal DNA from Chinese RhD-negative maternal plasma. (PubMed id 19545247)1, 4 Wang X.D....He Z.M. (Eur. J. Clin. Invest. 2009)
  6. [RHD gene polymorphism of RhD negative individuals in population of Fujian province]. (PubMed id 18426681)1, 4 Zhuo C.S....Wang C.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
  7. Prevalence of RHD 1227A and hybrid Rhesus box in the general Chinese population. (PubMed id 17196520)1, 4 Yang Y.F....Lin T.M. (Transl Res 2007)
  8. [RHD 1227A allele frequency among Rh negative population and random population]. (PubMed id 17204201)1, 4 Wu J.J....Yan L.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006)
  9. ABO and Rh D polymorphism among Tibetans in India. (PubMed id 17036929)1, 4 Tripathy V....Gupta R. (Hum. Biol. 2006)
  10. Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele. (PubMed id 16510313)1, 2 Shao C.P.... Zhou Y.Y. (Transfus. Apher. Sci. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
Disorders
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6007 HGNC: 10009 AceView: RHD Ensembl:ENSG00000187010 euGenes: HUgn6007
ECgene: RHD H-InvDB: RHD

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RHD Pharmacogenomics, SNPs, Pathways
dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh
GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=RHD[genesymbol]

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RHD gene:
Search GeneIP for patents involving RHD

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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