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Aliases for RHCG Gene

Aliases for RHCG Gene

  • Rh Family C Glycoprotein 2 3 5
  • Rhesus Blood Group Family Type C Glycoprotein 3 4
  • Rhesus Blood Group, C Glycoprotein 2 3
  • Rh Family Type C Glycoprotein 3 4
  • Tumor-Related Protein DRC2 3 4
  • Rh Glycoprotein Kidney 3 4
  • Rh Type C Glycoprotein 3 4
  • C15orf6 3 4
  • PDRC2 3 4
  • RHGK 3 4
  • Chromosome 15 Open Reading Frame 6 2
  • Ammonium Transporter Rh Type C 3
  • SLC42A3 3
  • CDRC2 4

External Ids for RHCG Gene

Previous HGNC Symbols for RHCG Gene

  • C15orf6

Previous GeneCards Identifiers for RHCG Gene

  • GC15M086419
  • GC15M083380
  • GC15M087601
  • GC15M087744
  • GC15M087815
  • GC15M090014
  • GC15M066127

Summaries for RHCG Gene

GeneCards Summary for RHCG Gene

RHCG (Rh Family C Glycoprotein) is a Protein Coding gene. Diseases associated with RHCG include Retinohepatoendocrinologic Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ankyrin binding and ammonium transmembrane transporter activity. An important paralog of this gene is RHBG.

UniProtKB/Swiss-Prot for RHCG Gene

  • Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Gene Wiki entry for RHCG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHCG Gene

Genomics for RHCG Gene

Regulatory Elements for RHCG Gene

Enhancers for RHCG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F089512 0.7 FANTOM5 ENCODE 5.2 -16.8 -16820 1.0 ZNF658 RHCG ENSG00000261478 ENSG00000259713
GH15F089551 0.7 FANTOM5 3.8 -55.2 -55168 0.2 MTA2 JUNB EBF1 TBX21 EED IKZF1 NBN TCF7 CREM SPI1 RHCG TICRR LINC00928
GH15F089498 1 ENCODE 0.8 -1.8 -1802 0.2 PKNOX1 ATF1 SIN3A FEZF1 BRCA1 ZNF2 GLIS2 KLF7 FOS ZHX2 LOC100631255 POLG GC15P089499 RHCG
GH15F089496 0.8 ENCODE 0.8 +0.2 179 0.2 CTCF PKNOX1 SAP130 ARID4B SIN3A RAD21 TEAD3 POLR2A SMC3 KLF13 RHCG LOC105370964
GH15F089499 0.8 ENCODE 0.8 -2.2 -2166 0.3 ATF1 PKNOX1 SIN3A FEZF1 ZEB1 HIC1 ZNF324 GATA3 CTBP1 ZBTB48 ENSG00000261478 GC15P089499 RHCG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHCG on UCSC Golden Path with GeneCards custom track

Promoters for RHCG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000413232 113 201 ELF3 CTCF PKNOX1 SAP130 ARID4B SIN3A RAD21 TEAD3 POLR2A SMC3

Genomic Location for RHCG Gene

Chromosome:
15
Start:
89,471,398 bp from pter
End:
89,496,613 bp from pter
Size:
25,216 bases
Orientation:
Minus strand

Genomic View for RHCG Gene

Genes around RHCG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHCG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHCG Gene

Proteins for RHCG Gene

  • Protein details for RHCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBD6-RHCG_HUMAN
    Recommended name:
    Ammonium transporter Rh type C
    Protein Accession:
    Q9UBD6
    Secondary Accessions:
    • A8K4D4
    • Q6X3Y4

    Protein attributes for RHCG Gene

    Size:
    479 amino acids
    Molecular mass:
    53179 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for RHCG Gene

neXtProt entry for RHCG Gene

Post-translational modifications for RHCG Gene

Other Protein References for RHCG Gene

No data available for DME Specific Peptides for RHCG Gene

Domains & Families for RHCG Gene

Gene Families for RHCG Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for RHCG Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBD6

UniProtKB/Swiss-Prot:

RHCG_HUMAN :
  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Family:
  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
genes like me logo Genes that share domains with RHCG: view

Function for RHCG Gene

Molecular function for RHCG Gene

UniProtKB/Swiss-Prot Function:
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Gene Ontology (GO) - Molecular Function for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008519 ammonium transmembrane transporter activity IEA,TAS --
GO:0030506 ankyrin binding IDA 12719424
genes like me logo Genes that share ontologies with RHCG: view
genes like me logo Genes that share phenotypes with RHCG: view

Animal Models for RHCG Gene

MGI Knock Outs for RHCG:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHCG

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHCG Gene

Localization for RHCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHCG Gene

Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHCG gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10852913
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 16928804
genes like me logo Genes that share ontologies with RHCG: view

Pathways & Interactions for RHCG Gene

genes like me logo Genes that share pathways with RHCG: view

Interacting Proteins for RHCG Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268122%0d%0a9606.ENSP00000299798%0d%0a9606.ENSP00000264938%0d%0a9606.ENSP00000295269%0d%0a9606.ENSP00000233969%0d%0a9606.ENSP00000263980%0d%0a
Selected Interacting proteins: ENSP00000268122 Q9UBD6-RHCG_HUMAN for RHCG Gene via STRING IID

Gene Ontology (GO) - Biological Process for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006873 cellular ion homeostasis IDA 14761968
GO:0006885 regulation of pH IEA --
GO:0015695 organic cation transport IBA --
GO:0015696 ammonium transport IEA,IGI 11062476
genes like me logo Genes that share ontologies with RHCG: view

No data available for SIGNOR curated interactions for RHCG Gene

Drugs & Compounds for RHCG Gene

(2) Drugs for RHCG Gene - From: IUPHAR and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]methylamine Pharma 0

(3) Additional Compounds for RHCG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with RHCG: view

Transcripts for RHCG Gene

Unigene Clusters for RHCG Gene

Rh family, C glycoprotein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHCG Gene

No ASD Table

Relevant External Links for RHCG Gene

GeneLoc Exon Structure for
RHCG
ECgene alternative splicing isoforms for
RHCG

Expression for RHCG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHCG Gene

This gene is overexpressed in Esophagus - Mucosa (x29.3), Vagina (x10.4), Cervix - Ectocervix (x6.6), and Minor Salivary Gland (x5.4).

Protein differential expression in normal tissues from HIPED for RHCG Gene

This gene is overexpressed in Cervix (21.5), Saliva (18.0), Urine (17.2), and Esophagus (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RHCG Gene



Protein tissue co-expression partners for RHCG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHCG Gene:

RHCG

SOURCE GeneReport for Unigene cluster for RHCG Gene:

Hs.459284

mRNA Expression by UniProt/SwissProt for RHCG Gene:

Q9UBD6-RHCG_HUMAN
Tissue specificity: Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.
genes like me logo Genes that share expression patterns with RHCG: view

Primer Products

Orthologs for RHCG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHCG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHCG 34 35
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia RHCG 34 35
  • 85.74 (n)
cow
(Bos Taurus)
Mammalia RHCG 34 35
  • 83.22 (n)
rat
(Rattus norvegicus)
Mammalia Rhcg 34
  • 81.7 (n)
mouse
(Mus musculus)
Mammalia Rhcg 34 16 35
  • 81.42 (n)
oppossum
(Monodelphis domestica)
Mammalia RHCG 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHCG 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHCG 34 35
  • 73.09 (n)
lizard
(Anolis carolinensis)
Reptilia RHCG 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhcg 34
  • 64.51 (n)
zebrafish
(Danio rerio)
Actinopterygii rhcga 34 35
  • 67.12 (n)
rhcgb 35
  • 62 (a)
OneToMany
rhcgl1 35
  • 62 (a)
OneToMany
wufj85f07 34
fruit fly
(Drosophila melanogaster)
Insecta Rh50 36 35
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea rhr-1 36 35
  • 40 (a)
rhr-2 36 35
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7075 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
CSA.7848 35
  • 42 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13103 34
Species where no ortholog for RHCG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHCG Gene

ENSEMBL:
Gene Tree for RHCG (if available)
TreeFam:
Gene Tree for RHCG (if available)

Paralogs for RHCG Gene

Paralogs for RHCG Gene

(10) SIMAP similar genes for RHCG Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RHCG: view

Variants for RHCG Gene

Sequence variations from dbSNP and Humsavar for RHCG Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10162871 -- 89,493,374(+) GCCTC(C/T)GAGGG intron-variant
rs10520683 -- 89,476,957(-) TTCTG(A/G)CTACA intron-variant
rs11073869 -- 89,478,813(+) AGGTT(C/G)GGCGC intron-variant
rs11073870 -- 89,483,525(+) GAACA(C/T)GCCCC intron-variant
rs111293763 -- 89,485,978(+) TGGTG(G/T)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHCG Gene

Variant ID Type Subtype PubMed ID
esv2750003 CNV deletion 23290073
esv34025 CNV loss 18971310
nsv1038140 CNV gain 25217958
nsv1141668 CNV deletion 24896259
nsv1150344 CNV deletion 26484159
nsv457245 CNV loss 19166990
nsv570386 CNV loss 21841781

Variation tolerance for RHCG Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHCG Gene

Human Gene Mutation Database (HGMD)
RHCG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHCG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHCG Gene

Disorders for RHCG Gene

MalaCards: The human disease database

(1) MalaCards diseases for RHCG Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinohepatoendocrinologic syndrome
  • rh deficiency syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RHCG in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHCG

Genetic Association Database (GAD)
RHCG
Human Genome Epidemiology (HuGE) Navigator
RHCG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHCG
genes like me logo Genes that share disorders with RHCG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHCG Gene

Publications for RHCG Gene

  1. Function of human Rh based on structure of RhCG at 2.1 A. (PMID: 20457942) Gruswitz F. … Stroud R.M. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 22 64
  2. Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PMID: 16477434) Marini A.-M. … Andre B. (Curr. Genet. 2006) 3 4 22 64
  3. Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. (PMID: 16580862) Zidi-Yahiaoui N. … Mouro-Chanteloup I. (Transfus. Clin. Biol. 2006) 3 4 22 64
  4. NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. (PMID: 14761968) Bakouh N. … Planelles G. (J. Biol. Chem. 2004) 3 4 22 64
  5. RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. (PMID: 12204676) Chen B.-S. … Wang M.-R. (Eur. J. Cancer 2002) 3 4 22 64

Products for RHCG Gene

Sources for RHCG Gene

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