Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RHCG Gene

protein-coding GIFtS: 56
GCID: GC15M090014

Rh Family, C Glycoprotein

(Previous names: chromosome 15 open reading frame 6, Rhesus blood group,...)
(Previous symbol: C15orf6)

11 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Rh Family, C Glycoprotein¹ ²		Tumor-Related Protein DRC2² ³
C15orf6¹ ² ³		PDRC2² ³
RHGK² ³ ⁵		Rh Type C Glycoprotein² ³
Rhesus Blood Group, C Glycoprotein¹ ²		Chromosome 15 Open Reading Frame 6¹
Rh Family Type C Glycoprotein² ³		SLC42A3²
Rh Glycoprotein Kidney² ³		Ammonium Transporter Rh Type C²
Rhesus Blood Group Family Type C Glycoprotein² ³		CDRC2³

External Ids:	HGNC: 18140¹	Entrez Gene: 51458²	Ensembl: ENSG00000140519⁷	OMIM: 605381⁵	UniProtKB: Q9UBD6³

Export aliases for RHCG gene to outside databases

Previous GC identifers: GC15M086419 GC15M083380 GC15M087601 GC15M087744 GC15M087815 GC15M066127

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RHCG Gene:

RHCG (Rh family, C glycoprotein) is a protein-coding gene. Diseases associated with RHCG include metabolic acidosis, and ovarian hyperstimulation syndrome, and among its related super-pathways are Transmembrane transport of small molecules and Na+/Cl- dependent neurotransmitter transporters. GO annotations related to this gene include ammonia transmembrane transporter activity and ankyrin binding. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6

Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia

secretion

Gene Wiki entry for RHCG Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.2 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHCG gene promoter:
AhR MIF-1 Tal-1beta Ik-3 E47 Arnt MZF-1 IRF-7A NF-Y
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHCG promoter sequence

Search SABiosciences Chromatin IP Primers for RHCG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHCG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25

RHCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHCG gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M090014: view genomic region (about GC identifiers)

Start:	89,998,680 bp from pter	End:	90,039,844 bp from pter
Size:	41,165 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6 (See protein sequence)

Recommended Name: Ammonium transporter Rh type C

Size: 479 amino acids; 53179 Da

Subunit: Homotrimer

Subcellular location: Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane

and in subapical vesicles (By similarity)

Developmental stage: Specifically expressed in fetal kidney

1 PDB 3D structure from and Proteopedia for RHCG:

3HD6 (3D)

Secondary accessions: A8K4D4 Q6X3Y4

Explore the universe of human proteins at neXtProt for RHCG: NX_Q9UBD6

Explore proteomics data for RHCG at MOPED

Post-translational modifications:

UniProtKB: N-glycosylated

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9UBD6

RHCG Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_057405.1

ENSEMBL proteins:

ENSP00000453588 ENSP00000268122 ENSP00000453496 ENSP00000452899 ENSP00000453716

ENSP00000438123

Reactome Protein details: Q9UBD6
Human Recombinant Protein Products for RHCG:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for RHCG OriGene Custom MassSpec OriGene Custom Protein Services for RHCG
	GenScript Custom Purified and Recombinant Proteins Services for RHCG
	Novus Biologicals RHCG Proteins Novus Biologicals RHCG Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RHCG

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IDA	10852913
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	--	--
GO:0016323	basolateral plasma membrane	IDA	16928804

RHCG for ontologies About GeneDecksing

RHCG Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RHCG
	GenScript Custom Superior Antibodies Services for RHCG
	Novus Biologicals RHCG Antibodies
	Abcam antibodies for RHCG
	Cloud-Clone Corp. Antibodies for RHCG
	ThermoFisher Antibodies for RHCG
	LSBio Antibodies in human, mouse, rat for RHCG

Assay Products for RHCG:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RHCG
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RHCG
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RHCG Cloud-Clone Corp. CLIAs for RHCG

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: RhCG

SLC42 family of non-erythroid Rhesus glycoprotein ammonium transporters

2 InterPro protein domains:

IPR024041 NH4_transpt_AmtB-like_dom

IPR002229 RhesusRHD

Graphical View of Domain Structure for InterPro Entry Q9UBD6

ProtoNet protein and cluster: Q9UBD6

2 Blocks protein domains:

IPB002229 Rhesus blood group protein signature

IPB010256 Rh-like protein/ammonium transporter

UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6

Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily

RHCG for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RHCG_HUMAN, Q9UBD6

Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia

secretion

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008519	ammonium transmembrane transporter activity	IGI	11062476
GO:0030506	ankyrin binding	IDA	12719424
GO:0051739	ammonia transmembrane transporter activity	IDA	16580862

RHCG for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rhcg):

growth/size	homeostasis/metabolism	mortality/aging	no phenotypic analysis	renal/urinary system
reproductive system

RHCG for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Rhcg^tm1Ibmm for RHCG

inGenious Targeting Laboratory - Custom generated mouse model solutions for RHCG

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHCG

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHCG
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RHCG:
		hsa-miR-596 hsa-miR-1184 hsa-miR-637
		SwitchGear 3'UTR luciferase reporter plasmid: RHCG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RHCG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHCG
		Sirion Biotech Custom design and validation of potent shRNA sequences against RHCG

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RHCG
			Sirion Biotech Customized adenovirus for overexpression of RHCG Customized adenovirus for potent knockdown of RHCG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for RHCG (see all 6) OriGene ORF clones in mouse, rat for RHCG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RHCG (NM_016321)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHCG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RHCG
		Search LifeMap BioReagents cell lines for RHCG
		Sirion Biotech Customized stable knockdown cell line services for RHCG Customized inducible knockdown cell line services for RHCG Customized stable overexpressing cell line services for RHCG Customized inducible overexpressing cell line services for RHCG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RHCG About

See pathways by source

SuperPath

Contained pathways About

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	0.50			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Amine compound SLC transporters

Amine compound SLC transporters

0.63

Rhesus glycoproteins mediate ammonium transport.

Rhesus glycoproteins mediate ammonium transport.

Pathways by source See SuperPaths
Show all pathways

5 Reactome Pathways for RHCG

	Rhesus glycoproteins mediate ammonium transport.
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Amine compound SLC transporters

RHCG for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RHCG

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006873	cellular ion homeostasis	IDA	14761968
GO:0006885	regulation of pH	IEA	--
GO:0015696	ammonium transport	IGI	11062476
GO:0015837	amine transport	NAS	10852913
GO:0030855	epithelial cell differentiation	NAS	12204676

RHCG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RHCG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RHCG

1 HMDB Compound for RHCG About this table

Compound	Synonyms	CAS #	PubMed Ids
Ammonia	NH3 (see all 31)	7664-41-7	--

1 IUPHAR Ligand for RHCG (RhCG) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
[¹⁴C]methylamine	None	None		--

3 Novoseek inferred chemical compound relationships for RHCG gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
amtb	90.9	1	16281947 (1)
methylammonium	90.3	1	11062476 (1)
ammonium	78.7	26	14761968 (5), 16580864 (3), 11062476 (3), 14656370 (2) (see all 9)

Search CenterWatch for drugs/clinical trials and news about RHCG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RHCG gene:

NM_016321.1

Unigene Cluster for RHCG:

Rh family, C glycoprotein

Hs.459284 [show with all ESTs]

Unigene Representative Sequence: BC030965

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000560081(uc002boa.2) ENST00000268122(uc002bnz.2) ENST00000558360

ENST00000558030 ENST00000558184(uc010bnq.1) ENST00000559638 ENST00000544600

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHCG
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RHCG:
		hsa-miR-596 hsa-miR-1184 hsa-miR-637
		SwitchGear 3'UTR luciferase reporter plasmid: RHCG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RHCG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHCG
		Sirion Biotech Custom design and validation of potent shRNA sequences against RHCG

Clone Products:		OriGene clones in human, mouse for RHCG (see all 6) OriGene ORF clones in mouse, rat for RHCG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RHCG (NM_016321)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHCG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCG

Primer Products:		OriGene qPCR primer pairs and template standards for RHCG OriGene qSTAR qPCR primer pairs in human, mouse for RHCG
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RHCG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHCG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHCG

Additional mRNA sequence:

AF081497.1 AF193809.1 AK290899.1 AK298252.1 AK298641.1 AK301640.1 AK310222.1 AK313238.1

AY257182.1 BC015461.1 BC030965.1

6 DOTS entries:

DT.206763 DT.65286547 DT.101979813 DT.100779178 DT.40216415 DT.91989395

24/80 AceView cDNA sequences (see all 80):

CR597837 AL603226 BF353627 BI762408 BX378267 BX284069 AW772195 BX356835

CR597827 BC015461 CK300037 CB128022 CA309850 BI517523 BQ007826 AY257182

BE143030 AI767967 AA595971 BI760859 BI764566 AF081497 BG678858 AA863266

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHCG expression in normal human tissues (normalized intensities) RHCG embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTTCCTCGG

About this image

RHCG expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/10 selected tissues (see all 10) fully expand


Kidney (Urinary System) fully expand to see all 2 entries
kidney ; cells in tubules
visceral organ/metanephros/calyx

Reproductive System (Reproductive System) fully expand to see all 2 entries
vagina ; squamous epithelial cells

Lower Urinary Tract (Urinary System)
visceral organ/metanephros/calyx

Oral Cavity (Gastrointestinal Tract)
oral mucosa ; squamous epithelial cells

Lung (Respiratory System)
Alveolar type II cells

See RHCG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHCG

SOURCE GeneReport for Unigene cluster: Hs.459284

UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6

Tissue specificity: Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous

epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney

SABiosciences Custom PCR Arrays for RHCG

Primer Products:		OriGene qPCR primer pairs and template standards for RHCG OriGene qSTAR qPCR primer pairs in human, mouse for RHCG
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RHCG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHCG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHCG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RHCG gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rhcg^{1 , 5}	Rhesus blood group-associated C glycoprotein^{1, 5}	81.42(n)¹ 77.87(a)¹		7 (45.09 cM)⁵ 56315¹ NM_019799.3¹ NP_062773.2¹ 79593363⁵
chicken (Gallus gallus)	Aves	RHCG¹	Rh family, C glycoprotein	73.32(n) 75.39(a)		415490 NM_001004370.1 NP_001004370.1
lizard (Anolis carolinensis)	Reptilia	RHCG⁶	Uncharacterized protein	71(a)	1 ↔ 1	GL343444.1(583928-632929)
zebrafish (Danio rerio)	Actinopterygii	wufj85f07²	wufj85f07	77.77(n)		337596 AF529360.1
fruit fly (Drosophila melanogaster)	Insecta	Rh50³	--	42(a)		64C4 --
worm (Caenorhabditis elegans)	Secernentea	rhr-1³	blood group RH(D) polypeptide	40(a) (best of 2)		V(5428029-5430058) --

ENSEMBL Gene Tree for RHCG (if available)
TreeFam Gene Tree for RHCG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RHCG gene

RHCE² RHBG² RHAG² RHD²

10 SIMAP similar genes for RHCG using alignment to 6 protein entries: RHCG_HUMAN (see all proteins):

RH50 RHAG RHBG RhDCw RHD RHCE

RhIVb(J) RhCE RhDTI RhD

RHCG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145818605^1,2		--	90014215(+)	`TCTACC/TCTCCT`	1	--	int¹		0	--	--	--	--
rs16943183^1,2	C,F,H	--	90014227(+)	`AAACCT/ATACCC`	1	--	int¹		8		NA NS EA	682
rs7166606^1,2	C,F,A,H	--	90014333(+)	`CGCAGT/CCCTGC`	1	--	int¹		12		NS EA NA WA CSA	787
rs7161881^1,2	C,F,A,H	--	90014394(+)	`TTCTCA/CAGGGC`	1	--	int¹		14		NA NS EA WA CSA	690
rs16943188^1,2	C,F,H	--	90014494(+)	`CTCTAG/CTACCC`	1	--	int¹		8		NA NS EA	682
rs77259145^1,2	C	--	90014563(+)	`TGAAGA/GTAAGG`	1	--	int¹		0	--	--	--	--
rs192993266^1,2		--	90014620(+)	`GCCCCA/GTTGGA`	1	--	int¹		0	--	--	--	--
rs141290066^1,2		--	90014702(+)	`AGGTCC/TGGGGG`	1	--	ut3¹		0	--	--	--	--
rs11558591^1,2	C,F	--	90014748(-)	`TACCCC/TGTGCC`	1	--	ut3¹ ese³		1		EA	120
rs2072693^1,2	C,F,O,A,H	--	90014945(-)	`GTCTGA/CCTGAG`	1	--	ut3¹ ese³		27		EA MN NA NS WA CSA	4128

HapMap Linkage Disequilibrium report for RHCG (89998680 - 90039844 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RHCG: About this table

Variant ID	Type	Subtype	PubMed ID
esv2750003	CNV	Deletion	23290073
esv34025	CNV	Loss	18971310
nsv457245	CNV	Loss	19166990

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHCG

DNA2.0 Custom Variant and Variant Library Synthesis for RHCG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RHCG for disorders           About GeneDecksing

OMIM gene information: 605381    OMIM disorders: --

11 diseases for RHCG:    About MalaCards

metabolic acidosis ovarian hyperstimulation syndrome renal tubular acidosis hemolytic anemia

infertility astrocytoma anemia squamous cell carcinoma

adenocarcinoma hepatitis prostatitis

4 diseases from the University of Copenhagen DISEASES database for RHCG:

Metabolic acidosis Ovarian hyperstimulation syndrome Renal tubular acidosis Infertility

1 Novoseek inferred disease relationship for RHCG gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	11.3	1	12204676 (1)

Genetic Association Database (GAD): RHCG
Human Genome Epidemiology (HuGE) Navigator: RHCG (4 documents)

Export disorders for RHCG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RHCG gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with RHCG)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. (PubMed id 10852913)^{1, 2, 3} Liu Z....Huang C.-H. (2000)
NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. (PubMed id 14761968)^{1, 2, 9} Bakouh N.... Planelles G. (2004)
RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. (PubMed id 12204676)^{1, 2, 9} Chen B.-S.... Wang M.-R. (2002)
Function of human Rh based on structure of RhCG at 2. 1 A. (PubMed id 20457942)^{1, 2, 9} Gruswitz F....Stroud R.M. (2010)
Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. (PubMed id 16580862)^{1, 2, 9} Zidi-Yahiaoui N.... Mouro-Chanteloup I. (2006)
The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. (PubMed id 11062476)^{1, 2, 9} Marini A.-M....Cherif-Zahar B. (2000)
Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PubMed id 16477434)^{1, 2, 9} Marini A.-M....Andre B. (2006)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)^{1, 4} Verma R....Levinson D.F. (2008)
Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. (PubMed id 15929723)^{1, 2} Zidi-Yahiaoui N.... Ripoche P. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51458	HGNC: 18140	AceView: RHCG	Ensembl:ENSG00000140519	euGenes: HUgn51458
ECgene: RHCG	H-InvDB: RHCG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RHCG	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RHCG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RHCG gene:
Search GeneIP for patents involving RHCG

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for RHCG
	OriGene qPCR primer pairs and template standards for RHCG		OriGene Protein Over-expression Lysate for RHCG
	OriGene Custom Mass Spec		OriGene clones in human, mouse for RHCG
	OriGene qSTAR qPCR primer pairs in human, mouse for RHCG		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for RHCG		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RHCG		OriGene Custom Protein Services for RHCG

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHCG
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHCG
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHCG
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHCG
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHCG
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHCG

	GenScript Custom Purified and Recombinant Proteins Services for RHCG		GenScript cDNA clones with any tag delivered in your preferred vector for RHCG
	GenScript Custom Assay Services for RHCG		GenScript Custom Superior Antibodies Services for RHCG
	GenScript Custom overexpressing Cell Line Services for RHCG		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RHCG promoter
	Search Chromatin IP Primers for RHCG
	RT² qPCR Primer Assay in human, mouse, rat RHCG
	Search GNC Networks for RHCG
	SABiosciences Custom PCR Arrays for RHCG

Search Tocris compounds for RHCG

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RHCG antibodies
	RHCG proteins
	RHCG lysates

	Antibodies for RHCG
	See all of Abcam's Antibodies, Kits and Proteins for RHCG
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for RHCG
	Antibodies for RHCG
	ELISAs for RHCG
	CLIAs for RHCG

Search LifeMap BioReagents cell lines for RHCG

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG

	SwitchGear 3'UTR luciferase reporter plasmids for RHCG
	SwitchGear Promoter luciferase reporter plasmids for RHCG

ThermoFisher Antibodies for RHCG

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCG

	inGenious Targeting Laboratory - Custom generated mouse model solutions for RHCG
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHCG

Customized:

	stable knockdown cell line services for RHCG
	inducible knockdown cell line services for RHCG
	design and validation of potent shRNA sequences against RHCG
	adenovirus for potent knockdown of RHCG
	stable overexpressing cell line services for RHCG
	inducible overexpressing cell line services for RHCG
	adenovirus for overexpression of RHCG

LSBio Antibodies in human, mouse, rat for RHCG

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RHCG gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

RHCG Gene

Rh Family, C Glycoprotein

Aliases
for RHCG gene

Summaries
for RHCG gene

Genomic Views
for RHCG gene

Proteins
for RHCG gene

Protein Domains /
Families
for RHCG gene

Function
for RHCG gene

Pathways & Interactions
for RHCG gene

Drugs & Compounds
for RHCG gene

Transcripts
for RHCG gene

Expression
for RHCG gene

Orthologs
for RHCG gene

Paralogs
for RHCG gene

Genomic Variants
for RHCG gene

Disorders / Diseases
for RHCG gene

Publications
for RHCG gene

External Searches for RHCG gene

Genome Databases showing RHCG gene

Other Databases showing RHCG gene

Specialized Databases showing RHCG gene

Intellectual Property
for RHCG gene

Products
for RHCG gene

View Random Gene

Advanced Search

Export list of displayed genes

RHCG Gene

Rh Family, C Glycoprotein

Aliasesfor RHCG gene

Summariesfor RHCG gene

Genomic Viewsfor RHCG gene

Proteinsfor RHCG gene

Protein Domains /Familiesfor RHCG gene

Functionfor RHCG gene

Pathways & Interactionsfor RHCG gene

Drugs & Compoundsfor RHCG gene

Transcriptsfor RHCG gene

Expression for RHCG gene

Orthologsfor RHCG gene

Paralogsfor RHCG gene

Genomic Variantsfor RHCG gene

Disorders / Diseasesfor RHCG gene

Publicationsfor RHCG gene

External Searches for RHCG gene

Genome Databases showing RHCG gene

Other Databases showing RHCG gene

Specialized Databases showing RHCG gene

Intellectual Propertyfor RHCG gene

Productsfor RHCG gene

View Random Gene

Aliases
for RHCG gene

Summaries
for RHCG gene

Genomic Views
for RHCG gene

Proteins
for RHCG gene

Protein Domains /
Families
for RHCG gene

Function
for RHCG gene

Pathways & Interactions
for RHCG gene

Drugs & Compounds
for RHCG gene

Transcripts
for RHCG gene

Expression
for RHCG gene

Orthologs
for RHCG gene

Paralogs
for RHCG gene

Genomic Variants
for RHCG gene

Disorders / Diseases
for RHCG gene

Publications
for RHCG gene

Intellectual Property
for RHCG gene

Products
for RHCG gene