RHCG Gene

Aliases
for RHCG gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC15M086419 GC15M083380 GC15M087601 GC15M087744 GC15M087815 GC15M066127

Summaries
for RHCG gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for RHCG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000015.9  NC_018926.2  NT_010194.18  

SwitchGear Promoter luciferase reporter plasmid: RHCG promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHCG

RHCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M090014:  view genomic region     (about GC identifiers)

Proteins
for RHCG gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for RHCG:

3HD6 (3D)    

Explore the universe of human proteins at neXtProt for RHCG: NX_Q9UBD6

Explore proteomics data for RHCG at MOPED

Post-translational modifications: 

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	antibodies-online peptides for RHCG

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RHCG Assay Products:

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Domains /
Families
for RHCG gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9UBD6

Find genes that share domains with RHCG           About GenesLikeMe

Function
for RHCG gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 3 alleles) (MGI details for Rhcg)

genOway: Develop your customized and physiologically relevant rodent model for RHCG

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		3 qRT-PCR Assays for microRNAs that regulate RHCG:
		hsa-miR-596 hsa-miR-1184 hsa-miR-637
		SwitchGear 3'UTR luciferase reporter plasmid: RHCG 3' UTR sequence

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RHCG

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG

Localization
for RHCG gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5

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Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

Pathways & Interactions
for RHCG gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for RHCG About     See pathways by source

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	SuperPath	Contained pathways About
1	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	SLC-mediated transmembrane transport 0.47 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.38 Transmembrane transport of small molecules 0.47 Rhesus glycoproteins mediate ammonium transport. 0.00

1 Reactome Pathway for RHCG

Rhesus glycoproteins mediate ammonium transport.

Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

Drugs & Compounds
for RHCG gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for RHCG gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for RHCG gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RHCG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTTCCTCGG

About this image

Lung (Respiratory System)
Alveolar type II cells
Tonsil (Hematopoietic System)

Primer Products:		OriGene qPCR primer pairs and template standards for RHCG OriGene qSTAR qPCR primer pairs in human, mouse for RHCG
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG

Orthologs
for RHCG gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for RHCG gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for RHCG gene

RHCE²  RHBG²  RHAG²  RHD²  

10 SIMAP similar genes for RHCG using alignment to 6 protein entries:     RHCG_HUMAN (see all proteins):

RH50    RHAG    RHBG    RhDCw    RHD    RHCE

RhIVb(J)    RhCE    RhDTI    RhD

Find genes that share paralogs with RHCG           About GenesLikeMe

Genomic Variants
for RHCG gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RHCG (see all 639)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1458186051,2		--	90014215(+)	TCTACC/TCTCCT	1	--	int1		0	--	--	--	--
rs169431831,2	C,F,H	--	90014227(+)	AAACCT/ATACCC	1	--	int1		8		NA NS EA	682
rs71666061,2	C,F,A,H	--	90014333(+)	CGCAGT/CCCTGC	1	--	int1		12		NS EA NA WA CSA	787
rs71618811,2	C,F,A,H	--	90014394(+)	TTCTCA/CAGGGC	1	--	int1		14		NA NS EA WA CSA	690
rs169431881,2	C,F,H	--	90014494(+)	CTCTAG/CTACCC	1	--	int1		8		NA NS EA	682
rs772591451,2	C	--	90014563(+)	TGAAGA/GTAAGG	1	--	int1		0	--	--	--	--
rs1929932661,2		--	90014620(+)	GCCCCA/GTTGGA	1	--	int1		0	--	--	--	--
rs1412900661,2		--	90014702(+)	AGGTCC/TGGGGG	1	--	ut31		0	--	--	--	--
rs115585911,2	C,F	--	90014748(-)	TACCCC/TGTGCC	1	--	ut31 ese3		1		EA	120
rs20726931,2	C,F,O,A,H	--	90014945(-)	GTCTGA/CCTGAG	1	--	ut31 ese3		27		EA MN NA NS WA CSA	4128

HapMap Linkage Disequilibrium report for RHCG (89998680 - 90039844 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RHCG:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2750003	CNV	Deletion	23290073
esv34025	CNV	Loss	18971310
nsv457245	CNV	Loss	19166990

Human Gene Mutation Database (HGMD): RHCG

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RHCG

DNA2.0 Custom Variant and Variant Library Synthesis for RHCG

Disorders / Diseases
for RHCG gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 Novoseek inferred disease relationship for RHCG gene    About this table

Publications
for RHCG gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. (PubMed id 10852913)^{1, 2, 3} Liu Z....Huang C.-H. (J. Biol. Chem. 2000)
2. NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. (PubMed id 14761968)^{1, 2, 9} Bakouh N.... Planelles G. (J. Biol. Chem. 2004)
3. RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. (PubMed id 12204676)^{1, 2, 9} Chen B.-S.... Wang M.-R. (Eur. J. Cancer 2002)
4. Function of human Rh based on structure of RhCG at 2.1 A. (PubMed id 20457942)^{1, 2, 9} Gruswitz F.... Stroud R.M. (Proc. Natl. Acad. Sci. U.S.A. 2010)
5. Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. (PubMed id 16580862)^{1, 2, 9} Zidi-Yahiaoui N.... Mouro-Chanteloup I. (Transfus. Clin. Biol. 2006)
6. The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. (PubMed id 11062476)^{1, 2, 9} Marini A.-M....Cherif-Zahar B. (Nat. Genet. 2000)
7. Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PubMed id 16477434)^{1, 2, 9} Marini A.-M....Andre B. (Curr. Genet. 2006)
8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
9. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)^{1, 4} Verma R....Levinson D.F. (Biol. Psychiatry 2008)
10. Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. (PubMed id 15929723)^{1, 2} Zidi-Yahiaoui N.... Ripoche P. (Biochem. J. 2005)

External Searches for RHCG gene

Genome Databases showing RHCG gene

Other Databases showing RHCG gene

Specialized Databases showing RHCG gene

Products
for RHCG gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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