RHCG Gene protein-coding GIFtS : 56 GCID: GC15 M090014
Rh Family, C Glycoprotein chromosome 15 open reading frame 6, Rhesus blood group,... C15orf6 )
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Aliasesfor RHCG gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Rh Family, C Glycoprotein 1 2 Tumor-Related Protein DRC22 3 C15orf61 2 3 PDRC22 3 RHGK2 3 5 Rh Type C Glycoprotein2 3 Rhesus Blood Group, C Glycoprotein1 2 Chromosome 15 Open Reading Frame 61 Rh Family Type C Glycoprotein2 3 SLC42A32 Rh Glycoprotein Kidney2 3 Ammonium Transporter Rh Type C2 Rhesus Blood Group Family Type C Glycoprotein2 3 CDRC23
Export aliases for RHCG gene to outside databases Previous GC identifers: GC15M086419 GC15M083380 GC15M087601 GC15M087744 GC15M087815 GC15M066127
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Summariesfor RHCG gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Summary for RHCG Gene: RHCG (Rh family, C glycoprotein) is a protein-coding gene. Diseases associated with RHCG include metabolic acidosis ovarian hyperstimulation syndrome related super-pathways are Transmembrane transport of small molecules and Na+/Cl- dependent neurotransmitter transporters . GO annotations related to this gene include ammonia transmembrane transporter activity and ankyrin binding . An important paralog of this gene is RHCE . UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6 Function : Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelialammonia secretion Gene Wiki entry for RHCG Gene
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Genomic Viewsfor RHCG gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.2 NT_010274.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RHCG gene promoter:AhR MIF-1 Tal-1beta Ik-3 E47 Arnt MZF-1 IRF-7A NF-Y Other transcription factors Search SABiosciences Chromatin IP Primers for RHCG Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q25 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25 RHCG Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M090014: view genomic region
(about GC identifiers )
Start: 89,998,680 bp from pter End:
90,039,844 bp from pter
Size: 41,165 bases Orientation:
minus strand
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Proteinsfor RHCG gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6 See
protein sequence )Recommended Name: Size : 479 amino acids; 53179 DaSubunit : HomotrimerSubcellular location : Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateralmembrane and in subapical vesicles (By similarity)
Developmental stage : Specifically expressed in fetal kidney1 PDB 3D structure from :3HD6 (3D) Secondary accessions : A8K4D4 Q6X3Y4Explore the universe of human proteins at neXtProt for RHCG: NX_Q9UBD6 Explore proteomics data for RHCG at MOPED Post-translational modifications:
UniProtKB: N-glycosylated View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q9UBD6 RHCG Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_057405.1 ENSEMBL proteins: ENSP00000453588 ENSP00000268122 ENSP00000453496 ENSP00000452899 ENSP00000453716 ENSP00000438123 Reactome Protein details: Q9UBD6 Human Recombinant Protein Products for RHCG: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing RHCG Antibody Products: Assay Products for RHCG:
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Protein
Domains /for RHCG gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: SLC: Solute carriers IUPHAR Guide to PHARMACOLOGY protein family classification: RhCG SLC42 family of non-erythroid Rhesus glycoprotein ammonium transporters 2 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry Q9UBD6 ProtoNet protein and cluster: Q9UBD6
2 Blocks protein domains : IPB002229 IPB010256 UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6 Similarity : Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamilyAbout GeneDecksing
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Functionfor RHCG gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: RHCG_HUMAN, Q9UBD6 Function : Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelialammonia secretion
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rhcg) :About GeneDecksing Animal Models: MGI mouse knock-out Rhcg tm1Ibmm for RHCGCell Line GenScript Custom overexpressing Cell Line Services for RHCG Search LifeMap BioReagents cell lines for RHCG In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG
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Pathways & Interactionsfor RHCG gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for RHCG About See pathways by source SuperPath Contained pathways About 1 SLC-mediated transmembrane transport 2 Amine compound SLC transporters 3 Rhesus glycoproteins mediate ammonium transport.
Pathways by source See SuperPaths Show all pathways 5 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHCG Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing
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Drugs & Compoundsfor RHCG gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for RHCG 1 HMDB Compound for RHCG About this table 1 IUPHAR Ligand for RHCG (RhCG) About this table 3 Novoseek inferred chemical compound relationships for RHCG gene About this table RHCG
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Transcriptsfor RHCG gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RHCG gene: NM_016321.1 Unigene Cluster for RHCG:
Rh family, C glycoprotein Hs.459284 [show with all ESTs ] Unigene Representative Sequence: BC030965 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000560081 (uc002boa.2 ) ENST00000268122 (uc002bnz.2 ) ENST00000558360 ENST00000558030 ENST00000558184 (uc010bnq.1 ) ENST00000559638 ENST00000544600 Primer RHCG human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AF081497.1 AF193809.1 AK290899.1 AK298252.1 AK298641.1 AK301640.1 AK310222.1 AK313238.1 AY257182.1 BC015461.1 BC030965.1
6 DOTS entries : DT.206763 DT.65286547
DT.101979813 DT.100779178 DT.40216415 DT.91989395 24/80 AceView cDNA sequences (see all 80 ):
CR597837 AL603226 BF353627 BI762408 BX378267 BX284069 AW772195 BX356835 CR597827 BC015461 CK300037 CB128022 CA309850 BI517523 BQ007826 AY257182 BE143030 AI767967 AA595971 BI760859 BI764566 AF081497 BG678858 AA863266 GeneLoc Exon Structure
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Expression for RHCG gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RHCG expression in normal human tissues
(normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: GCTTCCTCGGAbout this image
See RHCG Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RHCG SOURCE GeneReport for Unigene cluster: Hs.459284 UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6 Tissue specificity : Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamousepithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney SABiosciences Custom PCR Arrays for RHCG Primer RHCG human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG
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Orthologsfor RHCG gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for RHCG gene from 6/14 species (see all 14 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Rhcg1 5
Rhesus blood group-associated C glycoprotein1, 5
81.42(n) 1 77.87(a) 1
7 (45.09 cM) 5 56315 1 NM_019799.3 1 NP_062773.2 1 79593363 5
chicken Aves RHCG1
Rh family, C glycoprotein
73.32(n) 75.39(a)
415490 NM_001004370.1 NP_001004370.1
lizard Reptilia RHCG6
Uncharacterized protein
71(a)
1 ↔ 1
GL343444.1(583928-632929)
zebrafish Actinopterygii wufj85f072
wufj85f07
77.77(n)
337596 AF529360.1
fruit fly Insecta Rh503
--
42(a)
64C4 --
worm Secernentea rhr-13
blood group RH(D) polypeptide
40(a)
V(5428029-5430058) --
ENSEMBL Gene Tree for RHCG (if available)TreeFam Gene Tree for RHCG (if available)
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Paralogsfor RHCG gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RHCG gene RHCE 2 RHBG 2 RHAG 2 RHD 2 10 SIMAP similar genes for RHCG using alignment to 6 protein entries: RHCG_HUMAN (see all proteins ):RH50 RHAG RHBG RhDCw RHD RHCE RhIVb(J) RhCE RhDTI RhD About GeneDecksing
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Genomic Variantsfor RHCG gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 15 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for RHCG (89998680 - 90039844 bp)
Structural Variations Database of Genomic Variants (DGV) 3 variations for RHCG : About this table SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing RHCG
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Disorders
/ Diseasesfor RHCG gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 605381
OMIM disorders : --11 : About MalaCards metabolic acidosis ovarian hyperstimulation syndrome renal tubular acidosis hemolytic anemia infertility astrocytoma anemia squamous cell carcinoma adenocarcinoma hepatitis prostatitis 4 diseases from the University of Copenhagen DISEASES database for RHCG :Metabolic acidosis Ovarian hyperstimulation syndrome Renal tubular acidosis Infertility About GeneDecksing 1 Novoseek inferred disease relationship for RHCG gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell
11.3
1
12204676 (1)
Genetic Association Database (GAD): RHCG Human Genome Epidemiology (HuGE) Navigator: RHCG (4 documents) Export disorders for RHCG gene to outside databases
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Publicationsfor RHCG gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RHCG gene, integrated from 9 sources (see all 35 ):(articles sorted by number of sources associating them with RHCG) Utopia : connect your pdf to the dynamic
Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. (PubMed id 10852913) 1 , 2 , 3(2000) NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. (PubMed id 14761968) 1 , 2 , 9(2004) RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. (PubMed id 12204676) 1 , 2 , 9(2002) Function of human Rh based on structure of RhCG at 2. 1 A. (PubMed id 20457942) 1 , 2 , 9(2010) Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. (PubMed id 16580862) 1 , 2 , 9(2006) The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. (PubMed id 11062476) 1 , 2 , 9(2000) Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PubMed id 16477434) 1 , 2 , 9(2006) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 , 4(2010) Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154) 1 , 4(2008) Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. (PubMed id 15929723) 1 , 2 (2005)
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External Searches for RHCG gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RHCG gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RHCG gene
(According to HUGE )
About This Section --
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Specialized Databases showing RHCG gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for RHCG Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RHCG gene: RHCG GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RHCG gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHCG QIAGEN SeqTarget long-range PCR primers for resequencing RHCG QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG
ThermoFisher Antibodies for RHCG
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RHCG
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Aliases for RHCG
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