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Set Analyses:

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RHCG Gene

protein-coding GIFtS: 55
GCID: GC15M090014

Rh Family, C Glycoprotein

(Previous names: chromosome 15 open reading frame 6, Rhesus blood group,...)
(Previous symbol: C15orf6)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Rh Family, C Glycoprotein¹ ²		Tumor-Related Protein DRC2² ³
C15orf6¹ ² ³		PDRC2² ³
RHGK² ³ ⁵		Rh Type C Glycoprotein² ³
Rhesus Blood Group, C Glycoprotein¹ ²		Chromosome 15 Open Reading Frame 6¹
Rh Family Type C Glycoprotein² ³		SLC42A3²
Rh Glycoprotein Kidney² ³		Ammonium Transporter Rh Type C²
Rhesus Blood Group Family Type C Glycoprotein² ³		CDRC2³

External Ids:	HGNC: 18140¹	Entrez Gene: 51458²	Ensembl: ENSG00000140519⁷	OMIM: 605381⁵	UniProtKB: Q9UBD6³

Export aliases for RHCG gene to outside databases

Previous GC identifers: GC15M086419 GC15M083380 GC15M087601 GC15M087744 GC15M087815 GC15M066127

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHCG Gene:

RHCG (Rh family, C glycoprotein) is a protein-coding gene. Diseases associated with RHCG include ovarian hyperstimulation syndrome, and renal tubular acidosis. GO annotations related to this gene include and ankyrin binding. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6

Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial

ammonia secretion

Gene Wiki entry for RHCG Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000015.10 NC_018926.2 NT_010194.18

Regulatory elements:

Regulatory transcription factor binding sites in the RHCG gene promoter:
AhR MIF-1 Tal-1beta Ik-3 E47 Arnt MZF-1 IRF-7A NF-Y
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHCG promoter sequence

Search Chromatin IP Primers for RHCG

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHCG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25

RHCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHCG gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M090014: view genomic region (about GC identifiers)

Start:	89,998,680 bp from pter	End:	90,039,844 bp from pter
Size:	41,165 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6 (See protein sequence)

Recommended Name: Ammonium transporter Rh type C

Size: 479 amino acids; 53179 Da

Subunit: Homotrimer

Developmental stage: Specifically expressed in fetal kidney

1 PDB 3D structure from and Proteopedia for RHCG:

3HD6 (3D)

Secondary accessions: A8K4D4 Q6X3Y4

Explore the universe of human proteins at neXtProt for RHCG: NX_Q9UBD6

Explore proteomics data for RHCG at MOPED

Post-translational modifications:

N-glycosylated¹

Glycosylation² at Asn48

See RHCG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_057405.1

ENSEMBL proteins:

ENSP00000453588 ENSP00000268122 ENSP00000453496 ENSP00000452899 ENSP00000453716

ENSP00000438123

Reactome Protein details: Q9UBD6

RHCG Human Recombinant Protein Products:

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RHCG Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: RhCG

SLC42 family of non-erythroid Rhesus glycoprotein ammonium transporters

2 InterPro protein domains:

IPR024041 NH4_transpt_AmtB-like_dom

IPR002229 RhesusRHD

Graphical View of Domain Structure for InterPro Entry Q9UBD6

ProtoNet protein and cluster: Q9UBD6

2 Blocks protein domains:

IPB002229 Rhesus blood group protein signature

IPB010256 Rh-like protein/ammonium transporter

UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6

Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily

RHCG for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: RHCG_HUMAN, Q9UBD6

Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial

ammonia secretion

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008519	ammonium transmembrane transporter activity	IGI	11062476
GO:0030506	ankyrin binding	IDA	12719424

RHCG for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rhcg):

growth/size/body	homeostasis/metabolism	mortality/aging	no phenotypic analysis	renal/urinary system
reproductive system

RHCG for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Rhcg^tm1Ibmm for RHCG

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHCG

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHCG

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHCG

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHCG

miRNA Products:		Block miRNA regulation of human, mouse, rat RHCG using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate RHCG:
		hsa-miR-596 hsa-miR-1184 hsa-miR-637
		SwitchGear 3'UTR luciferase reporter plasmid: RHCG 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RHCG
		Predesigned siRNA for gene silencing in human, mouse, rat RHCG

Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

RHCG_HUMAN, Q9UBD6: Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral

membrane and in subapical vesicles (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5

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Gene Ontology (GO): Selected cellular component terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	IDA	10852913
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	--	--
GO:0016323	basolateral plasma membrane	IDA	16928804

RHCG for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RHCG About

See pathways by source

SuperPath

Contained pathways About

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

	SLC-mediated transmembrane transport	0.47			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.47			Rhesus glycoproteins mediate ammonium transport.	0.00

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for RHCG

Rhesus glycoproteins mediate ammonium transport.

RHCG for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for RHCG
Interactions:

Search GeneGlobe Interaction Network for RHCG

Gene Ontology (GO): Selected biological process terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006873	cellular ion homeostasis	IDA	14761968
GO:0006885	regulation of pH	IEA	--
GO:0015696	ammonium transport	IGI	11062476
GO:0015837	amine transport	NAS	10852913
GO:0030855	epithelial cell differentiation	NAS	12204676

RHCG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for RHCG

1 HMDB Compound for RHCG About this table

Compound	Synonyms	CAS #	PubMed Ids
Ammonia	NH3 (see all 31)	7664-41-7	--

1 IUPHAR Ligand for RHCG (RhCG) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
[¹⁴C]methylamine	None	None		--

3 Novoseek inferred chemical compound relationships for RHCG gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
amtb	90.9	1	16281947 (1)
methylammonium	90.3	1	11062476 (1)
ammonium	78.7	26	14761968 (5), 16580864 (3), 11062476 (3), 14656370 (2) (see all 9)

RHCG for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RHCG gene:

NM_016321.2

Unigene Cluster for RHCG:

Rh family, C glycoprotein

Hs.459284 [show with all ESTs]

Unigene Representative Sequence: BC030965

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000560081(uc002boa.2) ENST00000268122(uc002bnz.2) ENST00000558360

ENST00000558030 ENST00000558184(uc010bnq.1) ENST00000559638 ENST00000544600

miRNA Products:		Block miRNA regulation of human, mouse, rat RHCG using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate RHCG:
		hsa-miR-596 hsa-miR-1184 hsa-miR-637
		SwitchGear 3'UTR luciferase reporter plasmid: RHCG 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RHCG
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		GenScript: all cDNA clones in your preferred vector: RHCG (NM_016321)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHCG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCG

Primer Products:		OriGene qPCR primer pairs and template standards for RHCG OriGene qSTAR qPCR primer pairs in human, mouse for RHCG
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RHCG
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		QuantiFast Probe-based Assays in human, mouse, rat RHCG

Additional mRNA sequence:

AF081497.1 AF193809.1 AK290899.1 AK298252.1 AK298641.1 AK301640.1 AK310222.1 AK313238.1

AY257182.1 BC015461.1 BC030965.1

6 DOTS entries:

DT.206763 DT.65286547 DT.101979813 DT.100779178 DT.40216415 DT.91989395

Selected AceView cDNA sequences (see all 80):

AW772195 BI517523 CA309850 CR597827 BX378267 BX356835 BX284069 BF353627

CB128022 AL603226 CK300037 BC015461 CR597837 BI762408 AI310728 BG678858

BI760859 AF081497 CA310092 BE889218 U75825 BF354878 AA863266 BF354847

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RHCG expression in normal human tissues (normalized intensities) RHCG embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTTCCTCGG

About this image

RHCG expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Lung (Respiratory System)
Alveolar type II cells

Tonsil (Hematopoietic System)

RHCG Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RHCG Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.459284

UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6

Tissue specificity: Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous

epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RHCG gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rhcg^{1 , 5}	Rhesus blood group-associated C glycoprotein^{1, 5}	81.42(n)¹ 77.87(a)¹		7 (45.09 cM)⁵ 56315¹ NM_019799.3¹ NP_062773.2¹ 79593363⁵
chicken (Gallus gallus)	Aves	RHCG¹	Rh family, C glycoprotein	73.09(n) 74.84(a)		415490 NM_001004370.1 NP_001004370.1
lizard (Anolis carolinensis)	Reptilia	RHCG⁶	Rh family, C glycoprotein	71(a)	1 ↔ 1	GL343444.1(583928-632929)
tropical clawed frog (Xenopus tropicalis)	Amphibia	rhcg¹	Rh family, C glycoprotein	64.51(n) 66.52(a)		445260 NM_001003661.1 NP_001003661.1
zebrafish (Danio rerio)	Actinopterygii	wufj85f07²	wufj85f07	77.77(n)		337596 AF529360.1
fruit fly (Drosophila melanogaster)	Insecta	Rh50³	--	42(a)		64C4 --
worm (Caenorhabditis elegans)	Secernentea	rhr-1³	blood group RH(D) polypeptide	40(a) (best of 2)		V(5428029-5430058) --

ENSEMBL Gene Tree for RHCG (if available)
TreeFam Gene Tree for RHCG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RHCG gene

RHCE² RHBG² RHAG² RHD²

10 SIMAP similar genes for RHCG using alignment to 6 protein entries: RHCG_HUMAN (see all proteins):

RH50 RHAG RHBG RhDCw RHD RHCE

RhIVb(J) RhCE RhDTI RhD

RHCG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145818605^1,2		--	90014215(+)	`TCTACC/TCTCCT`	1	--	int¹		0	--	--	--	--
rs16943183^1,2	C,F,H	--	90014227(+)	`AAACCT/ATACCC`	1	--	int¹		8		NA NS EA	682
rs7166606^1,2	C,F,A,H	--	90014333(+)	`CGCAGT/CCCTGC`	1	--	int¹		12		NS EA NA WA CSA	787
rs7161881^1,2	C,F,A,H	--	90014394(+)	`TTCTCA/CAGGGC`	1	--	int¹		14		NA NS EA WA CSA	690
rs16943188^1,2	C,F,H	--	90014494(+)	`CTCTAG/CTACCC`	1	--	int¹		8		NA NS EA	682
rs77259145^1,2	C	--	90014563(+)	`TGAAGA/GTAAGG`	1	--	int¹		0	--	--	--	--
rs192993266^1,2		--	90014620(+)	`GCCCCA/GTTGGA`	1	--	int¹		0	--	--	--	--
rs141290066^1,2		--	90014702(+)	`AGGTCC/TGGGGG`	1	--	ut3¹		0	--	--	--	--
rs11558591^1,2	C,F	--	90014748(-)	`TACCCC/TGTGCC`	1	--	ut3¹ ese³		1		EA	120
rs2072693^1,2	C,F,O,A,H	--	90014945(-)	`GTCTGA/CCTGAG`	1	--	ut3¹ ese³		27		EA MN NA NS WA CSA	4128

HapMap Linkage Disequilibrium report for RHCG (89998680 - 90039844 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RHCG: About this table

Variant ID	Type	Subtype	PubMed ID
esv2750003	CNV	Deletion	23290073
esv34025	CNV	Loss	18971310
nsv457245	CNV	Loss	19166990

Human Gene Mutation Database (HGMD): RHCG

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RHCG

DNA2.0 Custom Variant and Variant Library Synthesis for RHCG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605381 OMIM disorders: --

11 diseases for RHCG: About MalaCards

ovarian hyperstimulation syndrome renal tubular acidosis metabolic acidosis hemolytic anemia

infertility astrocytoma squamous cell carcinoma tonsillitis

adenocarcinoma hepatitis prostatitis

4 diseases from the University of Copenhagen DISEASES database for RHCG:

Metabolic acidosis Ovarian hyperstimulation syndrome Renal tubular acidosis Infertility

RHCG for disorders About GeneDecksing

1 Novoseek inferred disease relationship for RHCG gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	11.3	1	12204676 (1)

Genetic Association Database (GAD): RHCG
Human Genome Epidemiology (HuGE) Navigator: RHCG (4 documents)

Export disorders for RHCG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RHCG gene, integrated from 10 sources (see all 37):
(articles sorted by number of sources associating them with RHCG)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. (PubMed id 10852913)^{1, 2, 3} Liu Z....Huang C.-H. (J. Biol. Chem. 2000)
NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. (PubMed id 14761968)^{1, 2, 9} Bakouh N.... Planelles G. (J. Biol. Chem. 2004)
RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. (PubMed id 12204676)^{1, 2, 9} Chen B.-S.... Wang M.-R. (Eur. J. Cancer 2002)
Function of human Rh based on structure of RhCG at 2.1 A. (PubMed id 20457942)^{1, 2, 9} Gruswitz F.... Stroud R.M. (Proc. Natl. Acad. Sci. U.S.A. 2010)
Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. (PubMed id 16580862)^{1, 2, 9} Zidi-Yahiaoui N.... Mouro-Chanteloup I. (Transfus. Clin. Biol. 2006)
The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. (PubMed id 11062476)^{1, 2, 9} Marini A.-M....Cherif-Zahar B. (Nat. Genet. 2000)
Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PubMed id 16477434)^{1, 2, 9} Marini A.-M....Andre B. (Curr. Genet. 2006)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)^{1, 4} Verma R....Levinson D.F. (Biol. Psychiatry 2008)
Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. (PubMed id 15929723)^{1, 2} Zidi-Yahiaoui N.... Ripoche P. (Biochem. J. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51458	HGNC: 18140	AceView: RHCG	Ensembl:ENSG00000140519	euGenes: HUgn51458
ECgene: RHCG	H-InvDB: RHCG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RHCG	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RHCG gene
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Patent Information for RHCG gene:
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Rh Family, C Glycoprotein

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