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RHCG Gene

protein-coding   GIFtS: 55
GCID: GC15M090014

Rh Family, C Glycoprotein

(Previous names: chromosome 15 open reading frame 6, Rhesus blood group,...)
(Previous symbol: C15orf6)
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Aliases
for RHCG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rh Family, C Glycoprotein1 2     Tumor-Related Protein DRC22 3
C15orf61 2 3     PDRC22 3
RHGK2 3 5     Rh Type C Glycoprotein2 3
Rhesus Blood Group, C Glycoprotein1 2     Chromosome 15 Open Reading Frame 61
Rh Family Type C Glycoprotein2 3     SLC42A32
Rh Glycoprotein Kidney2 3     Ammonium Transporter Rh Type C2
Rhesus Blood Group Family Type C Glycoprotein2 3     CDRC23

External Ids:    HGNC: 181401   Entrez Gene: 514582   Ensembl: ENSG000001405197   OMIM: 6053815   UniProtKB: Q9UBD63   

Export aliases for RHCG gene to outside databases

Previous GC identifers: GC15M086419 GC15M083380 GC15M087601 GC15M087744 GC15M087815 GC15M066127


Summaries
for RHCG gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHCG Gene:
RHCG (Rh family, C glycoprotein) is a protein-coding gene. GO annotations related to this gene include and ankyrin binding. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6
Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial
ammonia secretion

Gene Wiki entry for RHCG Gene


Genomic Views
for RHCG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHCG gene promoter:
         AhR   MIF-1   Tal-1beta   Ik-3   E47   Arnt   MZF-1   IRF-7A   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHCG promoter sequence
   Search Chromatin IP Primers for RHCG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q25

RHCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHCG gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M090014:  view genomic region     (about GC identifiers)

Start:
 89,998,680 bp from pter      End:
 90,039,844 bp from pter
Size:
 41,165 bases      Orientation:
 minus strand

Proteins
for RHCG gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6 (See protein sequence)
Recommended Name: Ammonium transporter Rh type C  
Size: 479 amino acids; 53179 Da
Subunit: Homotrimer
Developmental stage: Specifically expressed in fetal kidney
1 PDB 3D structure from and Proteopedia for RHCG:
3HD6 (3D)    
Secondary accessions: A8K4D4 Q6X3Y4

Explore the universe of human proteins at neXtProt for RHCG: NX_Q9UBD6

Explore proteomics data for RHCG at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn48

    • See RHCG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057405.1  
    ENSEMBL proteins: 
     ENSP00000453588   ENSP00000268122   ENSP00000453496   ENSP00000452899   ENSP00000453716  
     ENSP00000438123  
    Reactome Protein details: Q9UBD6

    RHCG Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RHCG
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    Novus Biologicals RHCG Proteins
    Novus Biologicals RHCG Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHCG

         		 Search eBioscience for Proteins for RHCG 

         		antibodies-online proteins for RHCG (3 products) 

         		antibodies-online peptides for RHCG

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    antibodies-online antibodies for RHCG (39 products) 

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    antibodies-online kits for RHCG (41 products) 

    Domains /
    Families
    for RHCG gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: RhCG
    SLC42 family of non-erythroid Rhesus glycoprotein ammonium transporters

    2 InterPro protein domains:
     IPR024041 NH4_transpt_AmtB-like_dom
     IPR002229 RhesusRHD

    Graphical View of Domain Structure for InterPro Entry Q9UBD6

    ProtoNet protein and cluster: Q9UBD6

    2 Blocks protein domains:
    IPB002229 Rhesus blood group protein signature
    IPB010256 Rh-like protein/ammonium transporter


    UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6
    Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily


    Find genes that share domains with RHCG           About GenesLikeMe


    Function
    for RHCG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHCG_HUMAN, Q9UBD6
    Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial
    ammonia secretion

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008519ammonium transmembrane transporter activity IGI11062476
    GO:0030506ankyrin binding IDA12719424
         
    Find genes that share ontologies with RHCG           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rhcg):
     growth/size/body  homeostasis/metabolism  mortality/aging  no phenotypic analysis  renal/urinary system 
     reproductive system 

    Find genes that share phenotypes with RHCG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rhcgtm1Ibmm for RHCG

       genOway: Develop your customized and physiologically relevant rodent model for RHCG

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat RHCG using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate RHCG:
    hsa-miR-596 hsa-miR-1184 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmid: RHCG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHCG

    Gene Editing
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    Cell Line
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    In Situ Assay
    Products:       
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    Localization
    for RHCG gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHCG_HUMAN, Q9UBD6: Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral
    membrane and in subapical vesicles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA10852913
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IDA16928804

    Find genes that share ontologies with RHCG           About GenesLikeMe


    Pathways & Interactions
    for RHCG gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHCG About    
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    		SLC-mediated transmembrane transport0.47
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.47
    		Rhesus glycoproteins mediate ammonium transport.0.00


    Find genes that share SuperPaths with RHCG           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways


    1 Reactome Pathway for RHCG
        Rhesus glycoproteins mediate ammonium transport.


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHCG
    Interactions:

        Search GeneGlobe Interaction Network for RHCG

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006873cellular ion homeostasis IDA14761968
    GO:0006885regulation of pH IEA--
    GO:0015696ammonium transport IGI11062476
    GO:0015837amine transport NAS10852913
    GO:0030855epithelial cell differentiation NAS12204676

    Find genes that share ontologies with RHCG           About GenesLikeMe



    Drugs & Compounds
    for RHCG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHCG

    1 HMDB Compound for RHCG    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--

    1 IUPHAR Ligand for RHCG (RhCG)    About this table
    LigandTypeActionAffinityPubmed IDs
    [14C]methylamine
    		NoneNone--

    3 Novoseek inferred chemical compound relationships for RHCG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amtb 90.9 1 16281947 (1)
    methylammonium 90.3 1 11062476 (1)
    ammonium 78.7 26 14761968 (5), 16580864 (3), 11062476 (3), 14656370 (2) (see all 9)



    Find genes that share compounds with RHCG           About GenesLikeMe



    Transcripts
    for RHCG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHCG gene: 
    NM_016321.2  

    Unigene Cluster for RHCG:

    Rh family, C glycoprotein
    Hs.459284  [show with all ESTs]
    Unigene Representative Sequence: BC030965
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560081(uc002boa.2) ENST00000268122(uc002bnz.2) ENST00000558360
    ENST00000558030 ENST00000558184(uc010bnq.1) ENST00000559638 ENST00000544600

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate RHCG:
    hsa-miR-596 hsa-miR-1184 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmid: RHCG 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for RHCG
    Predesigned siRNA for gene silencing in human, mouse, rat RHCG
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RHCG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHCG
      QuantiTect SYBR Green Assays in human, mouse, rat RHCG
      QuantiFast Probe-based Assays in human, mouse, rat RHCG

    Additional mRNA sequence: 

    AF081497.1 AF193809.1 AK290899.1 AK298252.1 AK298641.1 AK301640.1 AK310222.1 AK313238.1 
    AY257182.1 BC015461.1 BC030965.1 

    6 DOTS entries:

    DT.206763  DT.65286547  DT.101979813  DT.100779178  DT.40216415  DT.91989395 

    Selected AceView cDNA sequences (see all 80):

    AW772195 BI517523 CA309850 CR597827 BX378267 BX356835 BX284069 BF353627 
    CB128022 AL603226 CK300037 BC015461 CR597837 BI762408 AI310728 BG678858 
    BI760859 AF081497 CA310092 BE889218 U75825 BF354878 AA863266 BF354847 

    GeneLoc Exon Structure


    Expression
    for RHCG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHCG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCCTCGG
    RHCG Expression
    About this image


    RHCG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Tonsil (Hematopoietic System)
    RHCG Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    RHCG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459284

    UniProtKB/Swiss-Prot: RHCG_HUMAN, Q9UBD6
    Tissue specificity: Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous
    epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney

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    In Situ
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    Orthologs
    for RHCG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RHCG gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rhcg1 , 5 Rhesus blood group-associated C glycoprotein1, 5 81.42(n)1
    77.87(a)1    		   7 (45.09 cM)5
    563151  NM_019799.31  NP_062773.21 
     795933635 
    chicken
    (Gallus gallus)    		 Aves RHCG1 Rh family, C glycoprotein 73.09(n)
    74.84(a)    		   415490  NM_001004370.1  NP_001004370.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RHCG6
    		 Rh family, C glycoprotein
    		 71(a)
    		 1 ↔ 1
    		 GL343444.1(583928-632929)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia rhcg1 Rh family, C glycoprotein 64.51(n)
    66.52(a)    		   445260  NM_001003661.1  NP_001003661.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj85f072 wufj85f07 77.77(n)   337596  AF529360.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rh503   -- 42(a)   64C4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea rhr-13 blood group RH(D) polypeptide 40(a)
    (best of 2)    		   V(5428029-5430058)   --


    ENSEMBL Gene Tree for RHCG (if available)
    TreeFam Gene Tree for RHCG (if available)

    Paralogs
    for RHCG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHCG gene
    RHCE2  RHBG2  RHAG2  RHD2  
    10 SIMAP similar genes for RHCG using alignment to 6 protein entries:     RHCG_HUMAN (see all proteins):
    RH50    RHAG    RHBG    RhDCw    RHD    RHCE
    RhIVb(J)    RhCE    RhDTI    RhD

    Find genes that share paralogs with RHCG           About GenesLikeMe



    Genomic Variants
    for RHCG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RHCG (see all 639)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1458186051,2
    		--90014215(+) TCTACC/TCTCCT 1 -- int10--------
    rs169431831,2
    		C,F,H--90014227(+) AAACCT/ATACCC 1 -- int18Minor allele frequency- A:0.03NA NS EA 682
    rs71666061,2
    		C,F,A,H--90014333(+) CGCAGT/CCCTGC 1 -- int112Minor allele frequency- C:0.35NS EA NA WA CSA 787
    rs71618811,2
    		C,F,A,H--90014394(+) TTCTCA/CAGGGC 1 -- int114Minor allele frequency- C:0.17NA NS EA WA CSA 690
    rs169431881,2
    		C,F,H--90014494(+) CTCTAG/CTACCC 1 -- int18Minor allele frequency- C:0.03NA NS EA 682
    rs772591451,2
    		C--90014563(+) TGAAGA/GTAAGG 1 -- int10--------
    rs1929932661,2
    		--90014620(+) GCCCCA/GTTGGA 1 -- int10--------
    rs1412900661,2
    		--90014702(+) AGGTCC/TGGGGG 1 -- ut310--------
    rs115585911,2
    		C,F--90014748(-) TACCCC/TGTGCC 1 -- ut31 ese31Minor allele frequency- T:0.05EA 120
    rs20726931,2
    		C,F,O,A,H--90014945(-) GTCTGA/CCTGAG 1 -- ut31 ese327Minor allele frequency- C:0.47EA MN NA NS WA CSA 4128

    HapMap Linkage Disequilibrium report for RHCG (89998680 - 90039844 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RHCG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750003CNV Deletion23290073
    esv34025CNV Loss18971310
    nsv457245CNV Loss19166990

    Human Gene Mutation Database (HGMD): RHCG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHCG
    DNA2.0 Custom Variant and Variant Library Synthesis for RHCG

    Disorders / Diseases
    for RHCG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TryGeneCards Plus    		 OMIM gene information: 605381    OMIM disorders: --

    4 inferred disease relationships from the University of Copenhagen DISEASES database for RHCG:
    Metabolic acidosis     Ovarian hyperstimulation syndrome     Renal tubular acidosis     Infertility

    Find genes that share disorders with RHCG           About GenesLikeMe

    1 Novoseek inferred disease relationship for RHCG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 11.3 1 12204676 (1)

    Genetic Association Database (GAD): RHCG
    Human Genome Epidemiology (HuGE) Navigator: RHCG (4 documents)

    Export disorders for RHCG gene to outside databases

    Publications
    for RHCG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHCG gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with RHCG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. (PubMed id 10852913)1, 2, 3 Liu Z....Huang C.-H. (J. Biol. Chem. 2000)
    2. NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. (PubMed id 14761968)1, 2, 9 Bakouh N.... Planelles G. (J. Biol. Chem. 2004)
    3. RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. (PubMed id 12204676)1, 2, 9 Chen B.-S.... Wang M.-R. (Eur. J. Cancer 2002)
    4. Function of human Rh based on structure of RhCG at 2.1 A. (PubMed id 20457942)1, 2, 9 Gruswitz F.... Stroud R.M. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. (PubMed id 16580862)1, 2, 9 Zidi-Yahiaoui N.... Mouro-Chanteloup I. (Transfus. Clin. Biol. 2006)
    6. The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. (PubMed id 11062476)1, 2, 9 Marini A.-M....Cherif-Zahar B. (Nat. Genet. 2000)
    7. Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PubMed id 16477434)1, 2, 9 Marini A.-M....Andre B. (Curr. Genet. 2006)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)1, 4 Verma R....Levinson D.F. (Biol. Psychiatry 2008)
    10. Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. (PubMed id 15929723)1, 2 Zidi-Yahiaoui N.... Ripoche P. (Biochem. J. 2005)

    External Searches for RHCG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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    Genome Databases showing RHCG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51458 HGNC: 18140 AceView: RHCG Ensembl:ENSG00000140519 euGenes: HUgn51458
    ECgene: RHCG H-InvDB: RHCG

    Other Databases showing RHCG gene

    (According to HUGE)
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    TryGeneCards Plus    		   --

    Specialized Databases showing RHCG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RHCG Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RHCG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for RHCG gene:
    Search GeneIP for patents involving RHCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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