Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHCE Gene

protein-coding   GIFtS: 55
GCID: GC01M025688

Rh Blood Group, CcEe Antigens

(Previous names: Rhesus blood group, CcEe antigens)
(Previous symbol: RH)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rh Blood Group, CcEe Antigens1 2     Rh Blood Group C Antigen2
RH1 2     Rh Blood Group Rhce Antigen2
Rh Polypeptide 12 3     Rh Polypeptide I2
Rhesus C/E Antigens2 3     RHCE Blood Group Variant Crawford Antigen Rh432
RHC2 3     Rhesus Blood Group Antigen, RhC Antigen2
RHE2 3     Rhesus Blood Group CE Antigen2
Rhesus Blood Group, CcEe Antigens1     Rhesus Blood Group CE Protein2
CD240CE2     Rhesus Blood Group E Antigen2
RH30A2     Rhesus Blood Group Little E Antigen2
RHIXB2     Rhesus Blood Group Rhce Antigen2
RHPI2     Rhesus System C And E Polypeptides2
Rh42     Silenced Rh Blood Group CcEe Antigen2
RhIVb(J)2     Truncated RHCE2
RhVI2     Rh30A3
RhVIII2     RhIXB3
Blood Group Rh(CE) Polypeptide2     RhPI3
Blood Group RhCcEe Antigen2     CD240CE Antigen3
Rh Blood Group Antigen Evans2     

External Ids:    HGNC: 100081   Entrez Gene: 60062   Ensembl: ENSG000001886727   OMIM: 1117005   UniProtKB: P185773   

Export aliases for RHCE gene to outside databases

Previous GC identifers: GC01M025155 GC01M024671 GC01M024597 GC01M024969 GC01M025434 GC01M025561 GC01M023942


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHCE Gene:
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is
also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense
mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single
polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative
individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of
erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene
results in four transcript variants encoding four different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for RHCE Gene: 
RHCE (Rh blood group, CcEe antigens) is a protein-coding gene. Diseases associated with RHCE include appendiceal neoplasm, and rh deficiency syndrome. GO annotations related to this gene include ammonium transmembrane transporter activity. An important paralog of this gene is RHBG.

UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577
Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the
erythrocyte membrane

Gene Wiki entry for RHCE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHCE gene promoter:
         CREB   AREB6   Pax-4a   NF-Y   CBF(2)   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHCE promoter sequence
   Search SABiosciences Chromatin IP Primers for RHCE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHCE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

RHCE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHCE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M025688:  view genomic region     (about GC identifiers)

Start:
25,688,740 bp from pter      End:
25,756,683 bp from pter
Size:
67,944 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577 (See protein sequence)
Recommended Name: Blood group Rh(CE) polypeptide  
Size: 417 amino acids; 45560 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A7DW68 B7UDF3 B7UDF4 B7UDF5 B7UDF6 B7UDF7 B7UDF8 B7UDF9 B7UDG0 B7UDG1
B7UDG2 B7UDG3 Q02163 Q02164 Q02165 Q16160 Q2MJW0 Q2VC86 Q3LTM6 Q6AZX5 Q6J2U3 Q7RU06 Q8IZT2
Q8IZT3 Q8IZT4 Q8IZT5 Q9UD13 Q9UD14 Q9UD15 Q9UD16 Q9UD73 Q9UD74 Q9UEC2 Q9UEC3 Q9UPN0
Alternative splicing: 14 isoforms:  P18577-1   P18577-2   P18577-3   P18577-4   P18577-5   P18577-6   P18577-7   P18577-8   
P18577-9   P18577-10   P18577-11   P18577-12   P18577-13   P18577-14   

Explore the universe of human proteins at neXtProt for RHCE: NX_P18577

Explore proteomics data for RHCE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18577

  • RHCE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHCE Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_065231.3  NP_619522.3  NP_619523.3  NP_619524.3  

    ENSEMBL proteins: 
     ENSP00000294413   ENSP00000345084   ENSP00000311185   ENSP00000431741   ENSP00000344485  
     ENSP00000334570   ENSP00000435401   ENSP00000415417   ENSP00000416275   ENSP00000363472  
     ENSP00000243186   ENSP00000392809  

    Human Recombinant Protein Products for RHCE: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RHCE
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RHCE
    GenScript Custom Purified and Recombinant Proteins Services for RHCE
    Novus Biologicals RHCE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHCE 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS1438298
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    RHCE for ontologies           About GeneDecksing



    RHCE Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RHCE
    GenScript Custom Superior Antibodies Services for RHCE
    Novus Biologicals RHCE Antibody
    Abcam antibodies for RHCE
    Cloud-Clone Corp. Antibodies for RHCE 
    ThermoFisher Antibodies for RHCE
    LSBio Antibodies in human, mouse, rat for RHCE 

    Assay Products for RHCE: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RHCE
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RHCE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHCE 
    Cloud-Clone Corp. CLIAs for RHCE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    bloodgroup: Blood group antigens

    2 InterPro protein domains:
     IPR024041 NH4_transpt_AmtB-like_dom
     IPR002229 RhesusRHD

    Graphical View of Domain Structure for InterPro Entry P18577

    ProtoNet protein and cluster: P18577

    2 Blocks protein domains:
    IPB002229 Rhesus blood group protein signature
    IPB010256 Rh-like protein/ammonium transporter


    UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577
    Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily


    RHCE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHCE_HUMAN, P18577
    Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the
    erythrocyte membrane

         Genatlas biochemistry entry for RHCE:
    Rhesus blood group,locus CE,RH30 glycoprotein

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008519ammonium transmembrane transporter activity IEA--
         
    RHCE for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHCE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHCE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHCE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHCE 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHCE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RHCE
    SwitchGear 3'UTR luciferase reporter plasmidRHCE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHCE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHCE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHCE
    Sirion Biotech Customized adenovirus for overexpression of RHCE

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RHCE (see all 24)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RHCE (NM_138616)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHCE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCE
    Sirion Biotech Customized lentivirus for stable overexpression of RHCE 
                         Customized lentivirus expression plasmids for stable overexpression of RHCE 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RHCE
    Search LifeMap BioReagents cell lines for RHCE
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHCE

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015696ammonium transport ----

    RHCE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHCE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHCE

    1 Novoseek inferred chemical compound relationship for RHCE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxyribonucleic acid 25.1 2 7824249 (1)

    Search CenterWatch for drugs/clinical trials and news about RHCE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHCE gene (4 alternative transcripts): 
    NM_020485.4  NM_138616.3  NM_138617.3  NM_138618.3  

    Unigene Cluster for RHCE:

    Rh blood group, CcEe antigens
    Hs.523054  [show with all ESTs]
    Unigene Representative Sequence: NM_020485
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294413 ENST00000340849 ENST00000349320(uc001bkj.3) ENST00000527747
    ENST00000346452 ENST00000349438 ENST00000527187 ENST00000533771 ENST00000495048
    ENST00000413854 ENST00000455194(uc001bkh.3 uc001bki.3) ENST00000374352
    ENST00000243186(uc001bkf.3 uc001bkg.3) ENST00000425135
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHCE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RHCE
    SwitchGear 3'UTR luciferase reporter plasmidRHCE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHCE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHCE
    Clone
    Products:
         
    OriGene clones in human, mouse for RHCE (see all 24)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RHCE (NM_138616)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHCE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCE
    Sirion Biotech Customized lentivirus for stable overexpression of RHCE 
                         Customized lentivirus expression plasmids for stable overexpression of RHCE 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RHCE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHCE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHCE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHCE

    Additional mRNA sequence: 

    AB018644.1 AB018645.1 AB030388.1 AB049753.1 AF056965.1 AF510065.1 AF510066.1 AF510067.1 
    AF510068.1 AM295498.2 AM295506.2 AY603478.1 BC075081.2 BC139905.1 DQ178642.1 DQ266400.1 
    DQ322275.1 FR691748.1 FR691749.1 FR691750.1 GU474431.1 GU563377.1 GU810838.1 HE572747.1 
    HQ711843.1 HQ711844.1 HQ711846.1 HQ711847.1 M34015.1 S57967.1 X54534.1 X63095.1 
    X63096.1 X63098.1 

    16 DOTS entries:

    DT.75124277  DT.95159897  DT.121396511  DT.95260805  DT.100706780  DT.100880337  DT.100880329  DT.121396509 
    DT.305512  DT.92059273  DT.100880338  DT.95159906  DT.40295556  DT.40315244  DT.456144  DT.95351321 

    24/98 AceView cDNA sequences (see all 98):

    BM719724 BM684087 BX406173 BF081304 BM907493 BV204888 BU661907 BV183321 
    BV183326 AA836138 S57967 BV204886 AA722534 AK127547 BV183320 X54534 
    N53959 X63096 AB018644 BX426825 AF510067 BV204861 BX106517 BV204865 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RHCE (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                      -     -                                                                           
    SP2:                                      -     -                                         -                                 
    SP3:                                                                    -     -     -                                       
    SP4:                                            -                                                                           
    SP5:                    -     -     -           -                                                                           


    ECgene alternative splicing isoforms for RHCE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHCE expression in normal human tissues (normalized intensities)      RHCE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCAAAGT
    RHCE Expression
    About this image


    RHCE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Bone Marrow CD105+ Cells   
             umbilical cord reticulocytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Liver (Hepatobiliary System)

    See RHCE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHCE

    SOURCE GeneReport for Unigene cluster: Hs.523054

    UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577
    Tissue specificity: Restricted to tissues or cell lines expressing erythroid characters. Isoform 4g and isoform
    RhPI-Alpha are expressed in immature erythroblasts but not in mature erythroblasts

        SABiosciences Custom PCR Arrays for RHCE
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RHCE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHCE
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHCE
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHCE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RHCE gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhd1 Rh blood group, D antigen 71.27(n)
    58.35(a)
      19746  NM_011270.3  NP_035400.3 
    chicken
    (Gallus gallus)
    Aves RHD1 Rh blood group, D antigen 56.31(n)
    43.18(a)
      395121  NM_204467.1  NP_989798.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    41(a)
    24(a)
    1 ↔ many
    possible ortholog
    GL343703.1(120008-136413)
    4(155518610-155520073)
    zebrafish
    (Danio rerio)
    Actinopterygii rhd6
    rh506
    Rh50-like protein
    33(a)
    26(a)
    1 ↔ many
    possible ortholog
    13(46116954-46143214)
    8(38371549-38375675)
    fruit fly
    (Drosophila melanogaster)
    Insecta Rh506
    Rh50
    26(a)
    1 → many
    3L(4910368-4919321)
    worm
    (Caenorhabditis elegans)
    Secernentea rhr-16
    rhr-26
    Protein RHR-2
    24(a)
    23(a)
    many ↔ many
    many ↔ many
    V(5428160-5430431)
    V(11727898-11730160)


    ENSEMBL Gene Tree for RHCE (if available)
    TreeFam Gene Tree for RHCE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHCE gene
    RHD1 2  RHBG2  RHAG2  RHCG2  
    13 SIMAP similar genes for RHCE using alignment to 76 protein entries:     RHCE_HUMAN (see all proteins):
    RHD/RHCE    RhC    RhDCw    RhCE    RDH    RhIVb(J)
    RHD    RhD    RhDTI    RH50    RHAG    RHBG
    RHCG

    RHCE for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RHCE
    PGOHUM00000244639


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577
    Polymorphism: RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5
    blood group antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The
    molecular basis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103
    corresponds to Rh2 and Pro-103 to Rh4


    10/1290 SNPs in RHCE are shown (see all 1290)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6093201,2,4
    C,F,O,Hnon-pathogenic125717365(+) CAGAGC/GAGAGT 6 P A int1 mis1 ese323Minor allele frequency- G:0.17EA MN NS NA CSA WA EU 9386
    rs6767851,2,4
    C,F,Auntested125735202(+) CCCAGA/GAGGGA 8 P S mis1 ese31Minor allele frequency- G:0.32MN 184
    rs10533441,2,4
    Cuntested125735306(-) CTCAAA/GTTTCC 8 N S mis11Minor allele frequency- G:0.00NA 2
    rs1818604031,2,4
    Cuntested125735331(+) GCCAAG/TGGCCG 8 I L mis10--------
    VAR_0133014
    ----see VAR_0133012 R T mis40--------
    VAR_0069114
    ----see VAR_0069112 W C mis40--------
    VAR_0069124
    ----see VAR_0069122 A T mis40--------
    VAR_0133024
    ----see VAR_0133022 Q E mis40--------
    rs1997875631,2
    --25690905(+) AAACT-/TCGCGTA 4 -- int10--------
    rs2004955841,2
    --25692887(+) TTTTT-/CCTCTT 4 -- int10--------

    HapMap Linkage Disequilibrium report for RHCE (25688740 - 25756683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for RHCE (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7479CNV Insertion18451855
    nsv870522CNV Loss21882294
    nsv482037CNV Gain20164927
    nsv870470CNV Gain21882294
    nsv834480CNV Gain17160897
    nsv870477CNV Gain21882294
    esv996331CNV Gain20482838
    nsv871967CNV Gain21882294
    dgv200n71CNV Gain21882294
    esv28510CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): RHCE

    Locus Specific Mutation Databases (LSDB): RHCE
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RHCE
    DNA2.0 Custom Variant and Variant Library Synthesis for RHCE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 111700    OMIM disorders: --

    12 diseases for RHCE:    About MalaCards
    appendiceal neoplasm    rh deficiency syndrome    rh isoimmunization    hiv/aids
    kernicterus    autoimmune hemolytic anemia    bullous pemphigoid    hemolytic anemia
    liver cirrhosis    anemia    malaria    alcoholism

    4 diseases from the University of Copenhagen DISEASES database for RHCE:
    Rh isoimmunization     Anemia     Kernicterus     Autoimmune hemolytic anemia

    RHCE for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RHCE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hemolytic disease 84.3 11 7824249 (3), 7675408 (3), 15750007 (1)

    Genetic Association Database (GAD): RHCE
    Human Genome Epidemiology (HuGE) Navigator: RHCE (25 documents)

    Export disorders for RHCE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHCE gene, integrated from 9 sources (see all 152):
    (articles sorted by number of sources associating them with RHCE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular genetic basis of the human Rhesus blood group system. (PubMed id 8220426)1, 2, 3 Mouro I.... le van Kim C. (1993)
    2. E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop. (PubMed id 11724987)1, 2, 9 Kashiwase K.... Juji T. (2001)
    3. Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region. (PubMed id 8188244)1, 2, 9 Cherif-Zahar B....Colin Y. (1994)
    4. cDNA cloning of a 30 kDa erythrocyte membrane protein associated with Rh (Rhesus)-blood-group-antigen expression. (PubMed id 2123099)1, 2, 9 Avent N.D.... Anstee D.J. (1990)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Distribution of the FYBES and RHCE*ce(733C>G) alleles in an Argentinean population: implications for transfusion medicine. (PubMed id 18460195)1, 4 Cotorruelo C.M....Racca A.L. (2008)
    7. [RHCE genotyping in Chinese Han from north and Li from south] (PubMed id 17080665)1, 4 Sun Z.G....Huang H.W. (2006)
    8. Abnormal haemoglobin variants, ABO and Rh blood groups among student of African descent in Port Harcourt, Nigeria. (PubMed id 17140342)1, 4 Jeremiah Z.A. (2006)
    9. ABO, Rh, MNS, Duffy, Kidd,Yt, Scianna, and Colton blood group systems in indigenous Chinese. (PubMed id 15783300)1, 4 Yan L....He J. (2005)
    10. Effects of ABO/Rh blood groups, G-6-P-D enzyme activity and haemoglobin genotypes on malaria parasitaemia and parasite density. (PubMed id 17298125)1, 4 Nkuo-Akenji T.K....Akoachere J.F. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6006 HGNC: 10008 AceView: RHCE Ensembl:ENSG00000188672 euGenes: HUgn6006
    ECgene: RHCE H-InvDB: RHCE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHCE Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RHCE

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHCE gene:
    Search GeneIP for patents involving RHCE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RHCE  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RHCE  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RHCE  
     OriGene qSTAR qPCR primer pairs in human, mouse for RHCE   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RHCE   OriGene Custom Protein Services for RHCE  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHCE
     QIAGEN SeqTarget long-range PCR primers for resequencing RHCE
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHCE
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHCE
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHCE
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHCE
     GenScript Custom Purified and Recombinant Proteins Services for RHCE GenScript cDNA clones with any tag delivered in your preferred vector for RHCE
     GenScript Custom Assay Services for RHCE GenScript Custom Superior Antibodies Services for RHCE
     GenScript Custom overexpressing Cell Line Services for RHCE CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RHCE promoter
     Search Chromatin IP Primers for RHCE
     RT2 qPCR Primer Assay in human, mouse, rat RHCE
     GNC Network for RHCE
     SABiosciences Custom PCR Arrays for RHCE
     Search Tocris compounds for RHCE
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RHCE antibodies
     RHCE lysates
     Antibodies for RHCE
     See all of Abcam's Antibodies, Kits and Proteins for RHCE
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RHCE
     Antibodies for RHCE
     ELISAs for RHCE
     CLIAs for RHCE
     Search LifeMap BioReagents cell lines for RHCE
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCE
     SwitchGear 3'UTR luciferase reporter plasmids for RHCE
     SwitchGear Promoter luciferase reporter plasmids for RHCE
     ThermoFisher Antibodies for RHCE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCE
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RHCE
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHCE
    Customized:
     lentivirus for stable overexpression of RHCE
     lentivirus expression plasmids for stable overexpression of RHCE
     adenovirus for overexpression of RHCE
     LSBio Antibodies in human, mouse, rat for RHCE
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RHCE gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4