RHCE Gene
protein-coding GIFtS: 55
GCID: GC01M025688
|
|
Rh blood group, CcEe antigens(Previous names: Rhesus blood group, CcEe antigens )
(Previous symbol: RH)
| |
Aliases
for RHCE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rh Blood Group, CcEe Antigens1 2 | | Rh Blood Group Antigen Evans2 | | CD240CE1 2 | | Rh Blood Group C Antigen2 | | RH1 2 | | Rh Blood Group Rhce Antigen2 | | Rh Polypeptide 12 3 | | Rh Polypeptide I2 | | Rhesus C/E Antigens2 3 | | RHCE Blood Group Variant Crawford Antigen Rh432 | | RHC2 3 | | Rhesus Blood Group CE Antigen2 | | RHE2 3 | | Rhesus Blood Group CE Protein2 | | Rhesus Blood Group, CcEe Antigens1 | | Rhesus Blood Group E Antigen2 | | RH30A2 | | Rhesus Blood Group Little E Antigen2 | | RHIXB2 | | Rhesus Blood Group Rhce Antigen2 | | RHPI2 | | Rhesus System C And E Polypeptides2 | | Rh42 | | Silenced Rh Blood Group CcEe Antigen2 | | RhIVb(J)2 | | Truncated RHCE2 | | RhVI2 | | Rh30A3 | | RhVIII2 | | RhIXB3 | | Blood Group Rh(CE) Polypeptide2 | | RhPI3 | | Blood Group RhCcEe Antigen2 | | CD240CE Antigen3 |
Export aliases for RHCE gene to outside databasesPrevious GC identifers: GC01M025155 GC01M024671 GC01M024597 GC01M024969 GC01M025434 GC01M025561 GC01M023942 |
Summaries
for RHCE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RHCE:
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is alsothe most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations.The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a secondgene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by thepresence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this generesults in amorph-type Rh-null disease. Alternative splicing of this gene results in four transcript variants encodingfour different isoforms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577Function: May be part of an oligomeric complex which is likely to have a transport or channel function in theerythrocyte membrane
Gene Wiki entry for RHCE
|
Genomic Views
for RHCE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RHCE gene promoter:
CREB AREB6 Pax-4a NF-Y CBF(2) C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for RHCE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHCE |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11RHCE Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M025688: view genomic region
(about GC identifiers)
Start:
|
25,688,740 bp from pter |
End:
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25,756,683 bp from pter |
Size:
|
67,944 bases |
Orientation:
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minus strand |
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Proteins
for RHCE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577 (See
protein sequence)Recommended Name: Blood group Rh(CE) polypeptide Size: 417 amino acids; 45560 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A7DW68 B7UDF3 B7UDF4 B7UDF5 B7UDF6 B7UDF7 B7UDF8 B7UDF9 B7UDG0 B7UDG1 B7UDG2B7UDG3 Q02163 Q02164 Q02165 Q16160 Q2MJW0 Q2VC86 Q3LTM6 Q6AZX5 Q6J2U3 Q7RU06 Q8IZT2 Q8IZT3 Q8IZT4Q8IZT5 Q9UD13 Q9UD14 Q9UD15 Q9UD16 Q9UD73 Q9UD74 Q9UEC2 Q9UEC3 Q9UPN0Alternative splicing: 14 isoforms: P18577-1 P18577-2 P18577-3 P18577-4 P18577-5 P18577-6 P18577-7 P18577-8 P18577-9 P18577-10 P18577-11 P18577-12 P18577-13 P18577-14 Explore the universe of human proteins at neXtProt for RHCE: NX_P18577
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P18577
RHCE Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_065231.3 NP_619522.3 NP_619523.3 NP_619524.3
ENSEMBL proteins: ENSP00000345084 ENSP00000311185 ENSP00000431741 ENSP00000344485 ENSP00000294413 ENSP00000334570 ENSP00000435401 ENSP00000415417 ENSP00000416275 ENSP00000363472 ENSP00000243186 ENSP00000392809
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RHCE for ontologies About GeneDecksing
RHCE Antibody Products:
Assay Products for RHCE: |
Protein
Domains /
Families
for RHCE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RHCE for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P18577ProtoNet protein and cluster: P18577 2 Blocks protein families: IPB002229 Rhesus blood group protein signature IPB010256 Rh-like protein/ammonium transporter
UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily |
Function
for RHCE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577Function: May be part of an oligomeric complex which is likely to have a transport or channel function in theerythrocyte membrane Genatlas biochemistry entry for RHCE:Rhesus blood group,locus CE,RH30 glycoprotein
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHCE (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHCE (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): RHCE (NM_138616) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHCE | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCE |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCE |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008519 | ammonium transmembrane transporter activity |
IEA | -- |
RHCE for ontologies About GeneDecksing
|
Pathways & Interactions
for RHCE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHCE
|
Drugs & Compounds
for RHCE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RHCE for compounds About GeneDecksing
 Browse Tocris compounds for RHCE
1 Novoseek chemical compound relationship for RHCE gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| deoxyribonucleic acid |
25.1 |
2 |
7824249 (1) |
Search CenterWatch for drugs/clinical trials and news about RHCE
|
Transcripts
for RHCE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RHCE gene (4 alternative transcripts): NM_020485.4 NM_138616.3 NM_138617.3 NM_138618.3 Unigene Cluster for RHCE: Rh blood group, CcEe antigens Hs.523054 [show with all ESTs]Unigene Representative Sequence: NM_02048514 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340849 ENST00000349320(uc001bkj.3) ENST00000527747 ENST00000346452
ENST00000294413 ENST00000349438 ENST00000527187 ENST00000533771 ENST00000495048
ENST00000413854 ENST00000455194(uc001bkh.3 uc001bki.3) ENST00000374352
ENST00000243186(uc001bkf.3 uc001bkg.3) ENST00000425135
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHCE (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHCE (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): RHCE (NM_138616) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHCE | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCE |
Additional cDNA sequence: AB018644.1 AB018645.1 AB030388.1 AB049753.1 AF056965.1 AF510065.1 AF510066.1 AF510067.1 AF510068.1 AM295498.2 AM295506.2 AY603478.1 BC075081.2 BC139905.1 DQ178642.1 DQ266400.1 DQ322275.1 FR691748.1 FR691749.1 FR691750.1 GU474431.1 GU563377.1 GU810838.1 HE572747.1 M34015.1 S57967.1 X54534.1 X63095.1 X63096.1 X63098.1 18 DOTS entries: DT.75124277 DT.95159897 DT.121396511 DT.95260805 DT.100880338 DT.92059273 DT.305512 DT.100706780 DT.100880337 DT.100880329 DT.121396509 DT.121396546 DT.95159905 DT.95159906 DT.40295556 DT.40315244 DT.456144 DT.95351321 24/98 AceView cDNA sequences (see all 98): BM684087 BM907493 BF081304 BX406173 BM719724 AY603478 BV204889 S57967 BV183326 AF510067 AB018645 BX406635 BV204867 BV204887 BG201026 AB049753 BV204868 BC075081 AB030388 BV204866 M34015 BU665450 AK127547 AA722534
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RHCE (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RHCE
|
Expression
for RHCE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RHCE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGCAAAGT
About this image
See RHCE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHCE
SOURCE GeneReport for Unigene cluster: Hs.523054
UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577Tissue specificity: Restricted to tissues or cell lines expressing erythroid characters. Isoform 4g and isoformRhPI-Alpha are expressed in immature erythroblasts but not in mature erythroblasts
SABiosciences Custom PCR Arrays for RHCE
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHCE
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHCE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHCE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHCE | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCE |
Orthologs
for RHCE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RHCE gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RHD1 |
Rh blood group, D antigen |
56.31(n)
43.18(a) |
|
395121 NM_204467.1 NP_989798.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
42(a) |
1 → many |
GL343703.1(120634-136096) |
zebrafish
(Danio rerio) |
Actinopterygii |
rhd6 |
Rh blood group, D antigen |
34(a) |
1 → many |
13(46116954-46143214) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rh506 |
Rh50 |
26(a) |
possible ortholog |
3L(4910368-4919321) |
worm
(Caenorhabditis elegans) |
Secernentea |
rhr-16rhr-26 |
RH (Rhesus) antigen Related family member (rhr-2) |
25(a)23(a) |
many ↔ manymany ↔ many |
V(5428144-5430415) V(11727880-11730142) |
ENSEMBL Gene Tree for RHCE (if available)
TreeFam Gene Tree for RHCE (if available) |
Paralogs
for RHCE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RHCE gene
- RHD1 2 RHAG2 RHBG2 RHCG2
13 SIMAP similar genes for RHCE using alignment to 76 protein entries: RHCE_HUMAN (see all proteins):RHD/RHCE RhC RhDCw RDH RhIVb(J) RHD
RhD RhDTI RH50 Rh50 RHAG RHBG
RHCG
RHCE for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RHCE
PGOHUM00000244639
|
Genomic Variants
for RHCE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: RHCE_HUMAN, P18577Polymorphism: RhCE and RhD are responsible for the RH blood group system. The molecular basis of the E=Rh3/e=Rh5 bloodgroup antigens is a single variation in position 226; Pro-226 corresponds to Rh3 and Ala-226 to Rh5. The molecularbasis of the C=Rh2/c=Rh4 blood group antigens is a single variation in position 102; Ser-103 corresponds to Rh2 andPro-103 to Rh4
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RHCE (25688740 - 25756683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for RHCE
10 CNVs: 74419 74420 68246 31615 30380 2047 4217 84143 68245 0680
1 Indel: 68247
1 Inversion: 37099
Human Gene Mutation Database (HGMD): RHCE
Locus Specific Mutation Databases (LSDB): RHCE
Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHCE |
|
Disorders
/ Diseases
for RHCE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RHCE for disorders About GeneDecksing
OMIM gene information: 111700
OMIM disorders: --
14  diseases for RHCE: About MalaCardsrh-null disease rh-null disease, amorph type rh isoimmunization appendiceal neoplasm
rh deficiency syndrome autoimmune hemolytic anemia hemolytic anemia bullous pemphigoid
kernicterus liver cirrhosis anemia malaria
hiv/aids alcoholism
4 diseases from the University of Copenhagen DISEASES database for RHCE:Rh isoimmunization Anemia Kernicterus Autoimmune hemolytic anemia 1 Novoseek disease relationship for RHCE gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hemolytic disease |
84.3 |
11 |
7824249 (3), 7675408 (3), 15750007 (1) |
Genetic Association Database (GAD): RHCE
Human Genome Epidemiology (HuGE) Navigator: RHCE (25 documents)
Export disorders for RHCE gene to outside databases
|
Publications
for RHCE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RHCE gene, integrated from 9 sources (see all 147):
(articles sorted by number of sources associating them with RHCE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular genetic basis of the human Rhesus blood group system. (PubMed id 8220426)1, 2, 3 Mouro I.... le van Kim C. (1993)
- E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop. (PubMed id 11724987)1, 2, 9 Kashiwase K.... Juji T. (2001)
- Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region. (PubMed id 8188244)1, 2, 9 Cherif-Zahar B....Colin Y. (1994)
- cDNA cloning of a 30 kDa erythrocyte membrane protein associated with Rh (Rhesus)-blood-group-antigen expression. (PubMed id 2123099)1, 2, 9 Avent N.D.... Anstee D.J. (1990)
- RHCE represents the ancestral RH position, while RHD is the duplicated gene. (PubMed id 11902138)1, 2 Wagner F.F. and Flegel W.A. (2002)
- Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety. (PubMed id 12393640)1, 2 Noizat-Pirenne F.... Ansart-Pirenne H. (2002)
- 16Cys encoded by the RHce gene is associated with altered expression of the e antigen and is frequent in the R0 haplotype. (PubMed id 11380456)1, 2 Westhoff C.M.... Reid M.E. (2001)
- [Genetic predisposition to development of toxic liver cirrhosis caused by alcohol] (PubMed id 11436564)1, 4 Spitsyn V.A....Afanas'eva I.S. (2001)
- Intricate combinatorial patterns of exon splicing generate multiple Rh-related isoforms in human erythroid cells. (PubMed id 7789951)1, 2 Kajii E.... Ikemoto S. (1995)
- Identification of two Rh mRNA isoforms expressed in immature erythroblasts. (PubMed id 8117271)1, 2 Umenishi F.... Ikemoto S. (1994)
|
External Searches for RHCE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RHCE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RHCE gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RHCE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RHCE | Pharmacogenomics, SNPs, Pathways | | dbRBC/BGMUT | http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RHCE |
|
| | |
About This Section
| Patent Information for RHCE gene:
Search GeneIP for patents involving RHCE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RHCE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RHCE | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHCE | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHCE | | | OriGene Protein Over-expression Lysate for RHCE | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RHCE | | OriGene 3'-UTR Clone for RHCE | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHCE | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHCE | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RHCE | | OriGene Custom Protein Services for RHCE | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHCE | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHCE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHCE | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHCE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHCE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHCE |
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| | | | Search Tocris compounds for RHCE |
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 | | | RHCE Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHCE |
|  |  |  | | | | ThermoFisher Antibodies for RHCE |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHCE |
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