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Aliases for RHBG Gene

Aliases for RHBG Gene

  • Rh Family B Glycoprotein (Gene/Pseudogene) 2 3 5
  • Rhesus Blood Group, B Glycoprotein 2 3
  • Rhesus Blood Group Family Type B Glycoprotein 4
  • Ammonium Transporter Rh Type B 3
  • Rh Family Type B Glycoprotein 4
  • Rh Family, B Glycoprotein 3
  • Rh Type B Glycoprotein 4
  • SLC42A2 3

External Ids for RHBG Gene

Previous GeneCards Identifiers for RHBG Gene

  • GC01P154207
  • GC01P152104
  • GC01P153116
  • GC01P153555
  • GC01P153152
  • GC01P154605
  • GC01P127699

Summaries for RHBG Gene

Entrez Gene Summary for RHBG Gene

  • This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for RHBG Gene

RHBG (Rh Family B Glycoprotein (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ankyrin binding and ammonium transmembrane transporter activity. An important paralog of this gene is RHCG.

UniProtKB/Swiss-Prot for RHBG Gene

  • Functions as a specific ammonium transporter.

Gene Wiki entry for RHBG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHBG Gene

Genomics for RHBG Gene

Regulatory Elements for RHBG Gene

Enhancers for RHBG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156398 1.2 Ensembl ENCODE 17.7 +32.6 32615 1.0 NFRKB DMAP1 ZNF48 SLC30A9 GATA4 GATA2 FOS CREM THAP11 ZBTB2 RHBG CCT3 C1orf61 TSACC ISG20L2 PIR42696 ENSG00000237390
GH01F156366 1.4 Ensembl ENCODE 10.6 +4.5 4523 7.5 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 LOC246784 PEAR1 RHBG MSTO2P KIAA0907 RRNAD1 CCT3 SMG5 GC01M156384
GH01F156445 1.2 Ensembl ENCODE 11.6 +79.9 79907 0.3 ELF3 WRNIP1 KLF17 ARID4B SIN3A ZNF48 RAD21 RFX5 ELK1 ZNF143 MIR9-1 CCT3 RHBG TSACC NAXE PAQR6 BCAN C1orf61 ENSG00000236947
GH01F156450 1 ENCODE 11 +85.8 85808 1.7 ATF1 CREB3L1 SIN3A GLIS2 ZNF548 KDM4B ZNF263 SP3 YY2 NFYC KIAA0907 RRNAD1 MSTO2P LOC246784 MIR9-1 ENSG00000271267 HAPLN2 CCT3 RHBG BCAN
GH01F156474 1 ENCODE 10.8 +112.4 112399 7.7 PKNOX1 ARID4B SIN3A ZNF2 ZNF48 YY1 ELK1 ZNF143 FOS DEK C1orf61 MIR9-1 NAXE CCT3 RHBG MEF2D ENSG00000206651 GC01M156484 GC01M156440
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHBG on UCSC Golden Path with GeneCards custom track

Genomic Location for RHBG Gene

156,366,043 bp from pter
156,385,234 bp from pter
19,192 bases
Plus strand

Genomic View for RHBG Gene

Genes around RHBG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHBG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHBG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHBG Gene

Proteins for RHBG Gene

  • Protein details for RHBG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ammonium transporter Rh type B
    Protein Accession:
    Secondary Accessions:
    • A8K475
    • Q5SZW4
    • Q5SZW6
    • Q5SZW7
    • Q6P193
    • Q6YJI2
    • Q6YJI3

    Protein attributes for RHBG Gene

    441 amino acids
    Molecular mass:
    47231 Da
    Quaternary structure:
    • Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.
    • Sequence=AAG01086.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305}; Sequence=AAL05978.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305}; Sequence=AAN34363.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305}; Sequence=AAN34364.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305};

    Alternative splice isoforms for RHBG Gene


neXtProt entry for RHBG Gene

Post-translational modifications for RHBG Gene

No data available for DME Specific Peptides for RHBG Gene

Domains & Families for RHBG Gene

Gene Families for RHBG Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
genes like me logo Genes that share domains with RHBG: view

Function for RHBG Gene

Molecular function for RHBG Gene

UniProtKB/Swiss-Prot Function:
Functions as a specific ammonium transporter.

Gene Ontology (GO) - Molecular Function for RHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008519 ammonium transmembrane transporter activity TAS --
GO:0030506 ankyrin binding IPI 15611082
genes like me logo Genes that share ontologies with RHBG: view
genes like me logo Genes that share phenotypes with RHBG: view

Animal Models for RHBG Gene

MGI Knock Outs for RHBG:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHBG

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RHBG Gene

Localization for RHBG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHBG Gene

Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHBG gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 11024028
GO:0014731 spectrin-associated cytoskeleton IMP 18635543
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RHBG: view

Pathways & Interactions for RHBG Gene

genes like me logo Genes that share pathways with RHBG: view

Interacting Proteins for RHBG Gene

Selected Interacting proteins: Q9H310-RHBG_HUMAN for RHBG Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015695 organic cation transport IBA --
GO:0015696 ammonium transport ISS --
GO:0019740 nitrogen utilization IBA --
GO:0070634 transepithelial ammonium transport IDA 18032481
genes like me logo Genes that share ontologies with RHBG: view

No data available for SIGNOR curated interactions for RHBG Gene

Drugs & Compounds for RHBG Gene

(1) Drugs for RHBG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for RHBG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
genes like me logo Genes that share compounds with RHBG: view

Transcripts for RHBG Gene

Unigene Clusters for RHBG Gene

Rh family, B glycoprotein (gene/pseudogene):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHBG Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for RHBG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHBG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHBG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHBG Gene

This gene is overexpressed in Kidney - Cortex (x12.8), Brain - Cerebellum (x9.2), Brain - Cerebellar Hemisphere (x8.7), Ovary (x7.9), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for RHBG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.4) and Liver (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RHBG Gene

Protein tissue co-expression partners for RHBG Gene

NURSA nuclear receptor signaling pathways regulating expression of RHBG Gene:


SOURCE GeneReport for Unigene cluster for RHBG Gene:


mRNA Expression by UniProt/SwissProt for RHBG Gene:

Tissue specificity: Specifically expressed in kidney. Also detected in liver and ovary.
genes like me logo Genes that share expression patterns with RHBG: view

Primer Products

Orthologs for RHBG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHBG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHBG 34 35
  • 99.34 (n)
(Bos Taurus)
Mammalia RHBG 34 35
  • 89.52 (n)
(Canis familiaris)
Mammalia RHBG 34 35
  • 87.19 (n)
(Mus musculus)
Mammalia Rhbg 34 16 35
  • 85.57 (n)
(Rattus norvegicus)
Mammalia Rhbg 34
  • 85.04 (n)
(Monodelphis domestica)
Mammalia RHBG 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia RHBG 35
  • 64 (a)
(Gallus gallus)
Aves RHBG 35
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhbg 34
  • 65.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68642 34
(Danio rerio)
Actinopterygii rhbg 34 35
  • 65.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rh50 36 34 35
  • 55.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002011 34
  • 54.7 (n)
(Caenorhabditis elegans)
Secernentea rhr-2 36 35
  • 41 (a)
rhr-1 36 35
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7075 35
  • 45 (a)
CSA.7848 35
  • 43 (a)
-- 35
  • 42 (a)
Species where no ortholog for RHBG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHBG Gene

Gene Tree for RHBG (if available)
Gene Tree for RHBG (if available)

Paralogs for RHBG Gene

Variants for RHBG Gene

Sequence variations from dbSNP and Humsavar for RHBG Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10668520 -- 156,370,451(+) AAAAA(-/AA/AAA)TTAGC intron-variant
rs111832283 -- 156,385,677(+) CAAGG(G/T)CATCA downstream-variant-500B
rs112041962 -- 156,379,153(+) CCACA(C/T)CCAGC intron-variant
rs112232262 -- 156,367,108(+) CAGCC(A/G)GGCGC intron-variant, upstream-variant-2KB
rs112284257 -- 156,368,287(+) GCCCA(A/C/G)CCTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RHBG Gene

Variant ID Type Subtype PubMed ID
esv3426894 CNV insertion 20981092
nsv470742 CNV loss 18288195

Variation tolerance for RHBG Gene

Gene Damage Index Score: 16.97; 97.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHBG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHBG Gene

Disorders for RHBG Gene

Relevant External Links for RHBG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RHBG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHBG Gene

Publications for RHBG Gene

  1. Electroneutral ammonium transport by basolateral rhesus B glycoprotein. (PMID: 15284342) Ludewig U. (J. Physiol. (Lond.) 2004) 3 4 22 64
  2. Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals. (PMID: 11024028) Liu Z. … Huang C.-H. (J. Biol. Chem. 2001) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels. (PMID: 19357182) Brown A.C. … Toye A.M. (Am. J. Physiol. Renal Physiol. 2009) 3 22 64
  5. Phosphorylation and ankyrin-G binding of the C-terminal domain regulate targeting and function of the ammonium transporter RhBG. (PMID: 18635543) Sohet F. … Lopez C. (J. Biol. Chem. 2008) 3 22 64

Products for RHBG Gene

Sources for RHBG Gene

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