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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHBG Gene

protein-coding   GIFtS: 56
GCID: GC01P156339

Rh family, B glycoprotein (gene/pseudogene)

(Previous names: Rhesus blood group, B glycoprotein )
 Explore 5 diseases affiliated with
RHBG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RHBG    

Aliases
for RHBG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Rh Family, B Glycoprotein (Gene/Pseudogene)1 2     Ammonium Transporter Rh Type B2
SLC42A21 2     Rh Family Type B Glycoprotein3
Rhesus Blood Group, B Glycoprotein1 2     Rhesus Blood Group Family Type B Glycoprotein3
Rh Type B Glycoprotein2 3     

External Ids:    HGNC: 145721   Entrez Gene: 571272   Ensembl: ENSG000001326777   OMIM: 6070795   UniProtKB: Q9H3103   
ORGUL members:         
NONCODE:n407137    

Export aliases for RHBG gene to outside databases

Previous GC identifers: GC01P154207 GC01P152104 GC01P153116 GC01P153555 GC01P153152 GC01P154605 GC01P127699


Summaries
for RHBG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RHBG:
This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family
members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters
superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and
intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants.
(provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: RHBG_HUMAN, Q9H310
Function: Functions as a specific ammonium transporter

Gene Wiki entry for RHBG


Genomic Views
for RHBG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHBG gene promoter:
         GR   AML1a   GR-beta   HNF-4alpha2   HNF-4alpha1   E47   HEN1   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHBG promoter sequence
   Search SABiosciences Chromatin IP Primers for RHBG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

RHBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHBG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156339:  view genomic region     (about GC identifiers)

Start:
 156,339,003 bp from pter      End:
 156,355,011 bp from pter
Size:
 16,009 bases      Orientation:
 plus strand

Proteins
for RHBG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RHBG_HUMAN, Q9H310 (See protein sequence)
Recommended Name: Ammonium transporter Rh type B  
Size: 441 amino acids; 47231 Da
Subunit: Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane
Subcellular location: Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass
membrane protein
Developmental stage: Fetally expressed by kidney and to a lower extent in liver
Sequence caution: Sequence=AAG01086.1; Type=Frameshift; Positions=425; Sequence=AAL05978.1; Type=Frameshift;
Positions=425; Sequence=AAN34363.1; Type=Frameshift; Positions=425; Sequence=AAN34364.1; Type=Frameshift;
Positions=425;
Secondary accessions: A8K475 Q5SZW4 Q5SZW6 Q5SZW7 Q6P193 Q6YJI2 Q6YJI3
Alternative splicing: 5 isoforms:  Q9H310-1   Q9H310-2   Q9H310-3   Q9H310-4   Q9H310-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHBG: NX_Q9H310

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • View neXtProt modification sites for NX_Q9H310

    • RHBG Protein expression data from MOPED and PaxDb:    About this image 
    RHBG Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243324.1  NP_001243325.1  NP_065140.3  

    ENSEMBL proteins: 
     ENSP00000446140   ENSP00000357232   ENSP00000357230   ENSP00000413347   ENSP00000357228  
     ENSP00000357229   ENSP00000441197   ENSP00000383777   ENSP00000255013   ENSP00000389836  
    Reactome Protein details: Q9H310
    Human Recombinant Protein Products for RHBG: 
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    Uscn Proteins for RHBG

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA11024028
    GO:0014731spectrin-associated cytoskeleton IMP18635543
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    RHBG for ontologies           About GeneDecksing



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    ThermoFisher Antibody for RHBG

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    Uscn ELISAs and CLIAs for RHBG

    Protein Domains /
    Families
    for RHBG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RHBG for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR024041 NH4_transpt_AmtB-like_dom
     IPR002229 RhesusRHD

    Graphical View of Domain Structure for InterPro Entry Q9H310

    ProtoNet protein and cluster: Q9H310

    2 Blocks protein families:
    IPB002229 Rhesus blood group protein signature
    IPB010256 Rh-like protein/ammonium transporter


    UniProtKB/Swiss-Prot: RHBG_HUMAN, Q9H310
    Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily


    Function
    for RHBG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHBG_HUMAN, Q9H310
    Function: Functions as a specific ammonium transporter

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008519ammonium transmembrane transporter activity IDA15929723
    GO:0030506ankyrin binding IPI15611082
    GO:0051739ammonia transmembrane transporter activity ISS--
         
    RHBG for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RHBG:
     Decreased number of cells in m  Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Rhbg):
     normal 

    RHBG for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Rhbgtm1Rc for RHBG
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RHBG 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHBG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RHBG:
    hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: RHBG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHBG (see all 7)
    OriGene shRNA RFP: RHBG
    OriGene siRNA: RHBG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHBG
    Sirion Biotech Custom design and validation of potent shRNA sequences against RHBG 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RHBG
    Sirion Biotech Customized adenovirus for overexpression of RHBG 
    Sirion Biotech Customized adenovirus for potent knockdown of RHBG

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHBG (see all 3)
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    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for RHBG

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHBG


    Pathways & Interactions
    for RHBG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Rhesus glycoproteins mediate ammonium transport.
    		Rhesus glycoproteins mediate ammonium transport.1.00
    3Amine compound SLC transporters
    		Amine compound SLC transporters1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for RHBG
        Rhesus glycoproteins mediate ammonium transport.
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Amine compound SLC transporters



    RHBG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHBG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RHBG (ENSP000002550134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2B1ENSP000003371634STRING: ENSP00000337163
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015696ammonium transport ISS--
    GO:0055085transmembrane transport TAS--
    GO:0070634transepithelial ammonium transport IDA18032481
    GO:0072488ammonium transmembrane transport IDA15929723

    RHBG for ontologies           About GeneDecksing



    Drugs & Compounds
    for RHBG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHBG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHBG

    1 HMDB Compound for RHBG    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    3 Novoseek chemical compound relationships for RHBG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amtb 88.9 1 16281947 (1)
    methylammonium 88.2 2 16580864 (1), 15284342 (1)
    ammonium 78.9 18 16580864 (5), 18635543 (3), 14656370 (2), 15284342 (2) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about RHBG 

    Transcripts
    for RHBG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RHBG gene (3 alternative transcripts): 
    NM_001256395.1  NM_001256396.1  NM_020407.4  

    Unigene Cluster for RHBG:

    Rh family, B glycoprotein (gene/pseudogene)
    Hs.131835  [show with all ESTs]
    Unigene Representative Sequence: NR_046115
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467375 ENST00000544720 ENST00000368249(uc010pho.2) ENST00000368247(uc001fos.3)
    ENST00000446171(uc001for.3) ENST00000466013(uc010phm.1) ENST00000368245
    ENST00000494874 ENST00000477000 ENST00000368246 ENST00000537040 ENST00000400992(uc009wrz.3)
    ENST00000255013(uc010phn.1) ENST00000451864

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHBG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RHBG:
    hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: RHBG 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHBG (see all 7)
    OriGene shRNA RFP: RHBG
    OriGene siRNA: RHBG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHBG
    Sirion Biotech Custom design and validation of potent shRNA sequences against RHBG 
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RHBG (NM_020407)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHBG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHBG 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHBG

    Additional cDNA sequence: 

    AF193807.1 AK294641.1 AK308556.1 AY139092.1 AY139093.1 NR_046115.1 

    4 DOTS entries:

    DT.406310  DT.101978710  DT.100679344  DT.97766750 

    15 AceView cDNA sequences:

    AY139092 NM_020407 AI022447 AA693896 AY139093 AF193807 AK054780 BM546980 
    BC065218 BX090752 AI310325 BV181431 BI758836 R83832 R83833 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RHBG (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -     -                                                         
    SP2:              -     -                                                               
    SP3:              -     -     -                                                         
    SP4:              -     -                                                               
    SP5:                    -                                                               


    ECgene alternative splicing isoforms for RHBG

    Expression
    for RHBG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTAGAAGAG
    RHBG Expression
    About this image

    RHBG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePerivenous HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)

    See RHBG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHBG

    SOURCE GeneReport for Unigene cluster: Hs.131835

    UniProtKB/Swiss-Prot: RHBG_HUMAN, Q9H310
    Tissue specificity: Specifically expressed in kidney. Also detected in liver and ovary

        SABiosciences Expression via Pathway-Focused PCR Array including RHBG: 
              Hepatotoxicity in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for RHBG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RHBG gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RHBG6
    		 Rhesus blood group, B glycoprotein
    		 49(a)
    		 1 ↔ 1
    		 25(901753-904932)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686422 hypothetical protein MGC68642 73.13(n)    BC059979.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rhbg1 Rhesus blood group, B glycoprotein 64.89(n)
    66.2(a)    		   337596  NM_200071.2  NP_956365.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rh501 , 3 CG7499-PA1 45(a)3
    55.26(n)1
    47.85(a)1    		   64C43
    385891  NM_139683.21  NP_647940.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rhr-23 erythrocyte plasma membrane glycoprotein
    like    		 41(a)
    (best of 2)    		   V(11730577-11732756)   --


    ENSEMBL Gene Tree for RHBG (if available)
    TreeFam Gene Tree for RHBG (if available) 

    Paralogs
    for RHBG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHBG gene
    RHCE2  RHAG2  RHD2  RHCG2  
    18/70 SIMAP similar genes for RHBG using alignment to 7 protein entries:     RHBG_HUMAN (see all proteins) (see all similar genes):
    CALCOCO2    MRPL45    ANKRD55    HEXDC    UBE2B    FLJ16124
    FKBP11    MTO1    CLTA    DUSP3    ZNF554    ASCC1
    FRG1    NDC80    NLN    TMEM209    CCDC101    RRM2B

    RHBG for paralogs           About GeneDecksing



    Genomic Variants
    for RHBG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/301 NCBI SNPs in RHBG are shown (see all 301)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1865019521,2
    		--156337023(+) GAGCCC/GCTGAG 4 -- us2k10--------
    rs1457430491,2
    		--156337129(+) GCAGCC/TCTACC 4 -- us2k10--------
    rs1455235401,2
    		--156337133(+) CCCTAC/TCCTGC 4 -- us2k10--------
    rs38064101,2
    		C,F,H--156337134(+) CCTACC/TCTGCA 4 -- us2k110Minor allele frequency- T:0.28NS EA NA WA 764
    rs38064111,2
    		C,F,H--156337148(+) GTTCTG/AGGGGG 4 -- us2k15Minor allele frequency- A:0.03NS EA 524
    rs74140801,2
    		H--156337234(+) TTACAG/AACACT 4 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1914006081,2
    		--156337334(+) CCAGCC/TCCATG 4 -- us2k10--------
    rs1827204371,2
    		--156337438(+) CCACTA/GAGTAG 4 -- us2k10--------
    rs1861163681,2
    		--156337524(+) CACACA/GGGATG 4 -- us2k10--------
    rs1896551751,2
    		--156337617(+) TGTCCG/TTCCAG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHBG (156339003 - 156355011 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RHBG: --

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    Disorders / Diseases
    for RHBG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RHBG for disorders           About GeneDecksing

    OMIM gene information: 607079    OMIM disorders: --

    5 diseases for RHBG:    About MalaCards
    nephronopthisis    hemolytic anemia    hepatic encephalopathy    anemia
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for RHBG:
    Metabolic acidosis
    Human Genome Epidemiology (HuGE) Navigator: RHBG (3 documents)

    Export disorders for RHBG gene to outside databases

    Publications
    for RHBG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHBG gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RHBG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Electroneutral ammonium transport by basolateral rhesus B glycoprotein. (PubMed id 15284342)1, 2, 9 Ludewig U. (2004)
    2. Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals. (PubMed id 11024028)1, 2, 9 Liu Z.... Huang C.-H. (2001)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. (PubMed id 15611082)1, 2 Lopez C.... Colin Y. (2005)
    5. Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. (PubMed id 15929723)1, 2 Zidi-Yahiaoui N.... Ripoche P. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. (PubMed id 10852913)1, 3 Liu Z....Huang C.-H. (2000)
    9. RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels. (PubMed id 19357182)1, 9 Brown A.C....Toye A.M. (2009)
    10. Phosphorylation and ankyrin-G binding of the C-terminal domain regulate targeting and function of the ammonium transporter RhBG. (PubMed id 18635543)1, 9 Sohet F....Lopez C. (2008)

    External Searches for RHBG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RHBG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57127 HGNC: 14572 AceView: RHBG Ensembl:ENSG00000132677 euGenes: HUgn57127
    ECgene: RHBG H-InvDB: RHBG

    Other Databases showing RHBG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RHBG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHBG Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RHBG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RHBG gene:
    Search GeneIP for patents involving RHBG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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