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RHBG Gene

protein-coding   GIFtS: 58
GCID: GC01P156339

Rh Family, B Glycoprotein (Gene/Pseudogene)

(Previous names: Rhesus blood group, B glycoprotein)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rh Family, B Glycoprotein (Gene/Pseudogene)1 2     Rh Family Type B Glycoprotein3
Rhesus Blood Group, B Glycoprotein1 2     Rh Type B Glycoprotein3
SLC42A22     Rhesus Blood Group Family Type B Glycoprotein3
Ammonium Transporter Rh Type B2     

External Ids:    HGNC: 145721   Entrez Gene: 571272   Ensembl: ENSG000001326777   OMIM: 6070795   UniProtKB: Q9H3103   

Export aliases for RHBG gene to outside databases

Previous GC identifers: GC01P154207 GC01P152104 GC01P153116 GC01P153555 GC01P153152 GC01P154605 GC01P127699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHBG Gene:
This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein
family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia
transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane
spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple
transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for RHBG Gene:
RHBG (Rh family, B glycoprotein (gene/pseudogene)) is a protein-coding gene. GO annotations related to this gene include and ankyrin binding. An important paralog of this gene is RHCE.

UniProtKB/Swiss-Prot: RHBG_HUMAN, Q9H310
Function: Functions as a specific ammonium transporter

Gene Wiki entry for RHBG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHBG gene promoter:
         GR   AML1a   GR-beta   HNF-4alpha2   HNF-4alpha1   E47   HEN1   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHBG promoter sequence
   Search Chromatin IP Primers for RHBG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

RHBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHBG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156339:  view genomic region     (about GC identifiers)

Start:
156,339,003 bp from pter      End:
156,355,011 bp from pter
Size:
16,009 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHBG_HUMAN, Q9H310 (See protein sequence)
Recommended Name: Ammonium transporter Rh type B  
Size: 441 amino acids; 47231 Da
Subunit: Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane
Developmental stage: Fetally expressed by kidney and to a lower extent in liver
Sequence caution: Sequence=AAG01086.1; Type=Frameshift; Positions=425; Sequence=AAL05978.1; Type=Frameshift;
Positions=425; Sequence=AAN34363.1; Type=Frameshift; Positions=425; Sequence=AAN34364.1; Type=Frameshift;
Positions=425;
Secondary accessions: A8K475 Q5SZW4 Q5SZW6 Q5SZW7 Q6P193 Q6YJI2 Q6YJI3
Alternative splicing: 5 isoforms:  Q9H310-1   Q9H310-2   Q9H310-3   Q9H310-4   Q9H310-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHBG: NX_Q9H310

Explore proteomics data for RHBG at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn49

  • See RHBG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243324.1  NP_001243325.1  NP_065140.3  

    ENSEMBL proteins: 
     ENSP00000446140   ENSP00000357232   ENSP00000357230   ENSP00000413347   ENSP00000357228  
     ENSP00000357229   ENSP00000441197   ENSP00000383777   ENSP00000255013   ENSP00000389836  
    Reactome Protein details: Q9H310

    RHBG Human Recombinant Protein Products:

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    antibodies-online peptides for RHBG

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    antibodies-online antibodies for RHBG (22 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: RhBG
    SLC42 family of non-erythroid Rhesus glycoprotein ammonium transporters

    2 InterPro protein domains:
     IPR024041 NH4_transpt_AmtB-like_dom
     IPR002229 RhesusRHD

    Graphical View of Domain Structure for InterPro Entry Q9H310

    ProtoNet protein and cluster: Q9H310

    2 Blocks protein domains:
    IPB002229 Rhesus blood group protein signature
    IPB010256 Rh-like protein/ammonium transporter


    UniProtKB/Swiss-Prot: RHBG_HUMAN, Q9H310
    Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily


    Find genes that share domains with RHBG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHBG_HUMAN, Q9H310
    Function: Functions as a specific ammonium transporter

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008519ammonium transmembrane transporter activity ISS--
    GO:0030506ankyrin binding IPI15611082
         
    Find genes that share ontologies with RHBG           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RHBG:
     Decreased number of cells in m  Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rhbg):
     homeostasis/metabolism  normal  renal/urinary system 

    Find genes that share phenotypes with RHBG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rhbgtm1Rc for RHBG

       genOway: Develop your customized and physiologically relevant rodent model for RHBG

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RHBG:
    hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidRHBG 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHBG_HUMAN, Q9H310: Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane;
    Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA11024028
    GO:0014731spectrin-associated cytoskeleton IMP18635543
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with RHBG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHBG About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Rhesus glycoproteins mediate ammonium transport.0.00


    Find genes that share SuperPaths with RHBG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RHBG
        Rhesus glycoproteins mediate ammonium transport.


        Pathway & Disease-focused RT2 Profiler PCR Array including RHBG: 
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RHBG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RHBG (ENSP000002550134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2B1ENSP000003371634STRING: ENSP00000337163
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015696ammonium transport ISS--
    GO:0055085transmembrane transport TAS--
    GO:0070634transepithelial ammonium transport IDA18032481
    GO:0072488ammonium transmembrane transport ISS--

    Find genes that share ontologies with RHBG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHBG

    1 HMDB Compound for RHBG    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--

    3 Novoseek inferred chemical compound relationships for RHBG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amtb 88.9 1 16281947 (1)
    methylammonium 88.2 2 16580864 (1), 15284342 (1)
    ammonium 78.9 18 16580864 (5), 18635543 (3), 14656370 (2), 15284342 (2) (see all 6)



    Find genes that share compounds with RHBG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHBG gene (3 alternative transcripts): 
    NM_001256395.1  NM_001256396.1  NM_020407.4  

    Unigene Cluster for RHBG:

    Rh family, B glycoprotein (gene/pseudogene)
    Hs.131835  [show with all ESTs]
    Unigene Representative Sequence: NR_046115
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467375 ENST00000544720 ENST00000368249(uc010pho.2) ENST00000368247(uc001fos.3)
    ENST00000446171(uc001for.3) ENST00000466013(uc010phm.1) ENST00000368245
    ENST00000494874 ENST00000477000 ENST00000368246 ENST00000537040 ENST00000400992(uc009wrz.3)
    ENST00000255013(uc010phn.1) ENST00000451864
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RHBG:
    hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidRHBG 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RHBG
    Predesigned siRNA for gene silencing in human, mouse, rat RHBG
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    GenScript: all cDNA clones in your preferred vector: RHBG (NM_020407)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHBG
      QuantiTect SYBR Green Assays in human, mouse, rat RHBG
      QuantiFast Probe-based Assays in human, mouse, rat RHBG

    Additional mRNA sequence: 

    AF193807.1 AK294641.1 AK308556.1 AY139092.1 AY139093.1 NR_046115.1 

    4 DOTS entries:

    DT.406310  DT.101978710  DT.100679344  DT.97766750 

    15 AceView cDNA sequences:

    AF193807 AY139092 NM_020407 AI022447 AA693896 AY139093 BM546980 BC065218 
    AK054780 BX090752 AI310325 BI758836 BV181431 R83832 R83833 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RHBG (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -     -                                                         
    SP2:              -     -                                                               
    SP3:              -     -     -                                                         
    SP4:              -     -                                                               
    SP5:                    -                                                               


    ECgene alternative splicing isoforms for RHBG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAGAAGAG
    RHBG Expression
    About this image


    RHBG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    RHBG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHBG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131835

    UniProtKB/Swiss-Prot: RHBG_HUMAN, Q9H310
    Tissue specificity: Specifically expressed in kidney. Also detected in liver and ovary

        Pathway & Disease-focused RT2 Profiler PCR Array including RHBG: 
              Hepatotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHBG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RHBG gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhbg1 , 5 Rhesus blood group-associated B glycoprotein1, 5 85.57(n)1
    85.49(a)1
      3 (38.78 cM)5
    581761  NM_021375.31  NP_067350.21 
     882428745 
    chicken
    (Gallus gallus)
    Aves RHBG6
    Gallus gallus Rh family, B glycoprotein (RHBG), mR...
    48(a)
    1 ↔ 1
    25(511571-515860)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    many ↔ many
    4(155518610-155520073)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686422 hypothetical protein MGC68642 73.13(n)    BC059979.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rhbg1 Rhesus blood group, B glycoprotein 65.02(n)
    66.2(a)
      337596  NM_200071.2  NP_956365.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rh501 , 3 Rh501 45(a)3
    55.53(n)1
    47.63(a)1
      64C43
    385891  NM_001274505.11  NP_001261434.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rhr-23 erythrocyte plasma membrane
    glycoprotein like
    41(a)
    (best of 2)
      V(11730577-11732756)   --


    ENSEMBL Gene Tree for RHBG (if available)
    TreeFam Gene Tree for RHBG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHBG gene
    RHCE2  RHAG2  RHD2  RHCG2  
    Selected SIMAP similar genes for RHBG using alignment to 7 protein entries:     RHBG_HUMAN (see all proteins) (see all similar genes):
    CALCOCO2    MRPL45    ZNF429    HEXDC    UBE2B    FLJ16124
    FKBP11    MTO1    PARK2    CLTA    DUSP3    ZNF554
    ASCC1    FRG1    NDC80    NLN    TMEM209    CCDC101

    Find genes that share paralogs with RHBG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHBG (see all 411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865019521,2
    C--156337023(+) GAGCCC/GCTGAG 4 -- us2k10--------
    rs1457430491,2
    --156337129(+) GCAGCC/TCTACC 4 -- us2k10--------
    rs1455235401,2
    --156337133(+) CCCTAC/TCCTGC 4 -- us2k10--------
    rs38064101,2
    C,F,H--156337134(+) CCTACC/TCTGCA 4 -- us2k110Minor allele frequency- T:0.28NS EA NA WA 764
    rs38064111,2
    C,F,H--156337148(+) GTTCTG/AGGGGG 4 -- us2k15Minor allele frequency- A:0.03NS EA 524
    rs74140801,2
    H--156337234(+) TTACAG/AACACT 4 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1914006081,2
    --156337334(+) CCAGCC/TCCATG 4 -- us2k10--------
    rs1827204371,2
    --156337438(+) CCACTA/GAGTAG 4 -- us2k10--------
    rs1861163681,2
    --156337524(+) CACACA/GGGATG 4 -- us2k10--------
    rs1896551751,2
    C--156337617(+) TGTCCG/TTCCAG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHBG (156339003 - 156355011 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RHBG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872471CNV Loss21882294
    nsv470742CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607079    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RHBG:
    Metabolic acidosis

    Find genes that share disorders with RHBG           About GenesLikeMe

    Genetic Association Database (GAD): RHBG
    Human Genome Epidemiology (HuGE) Navigator: RHBG (3 documents)

    Export disorders for RHBG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHBG gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with RHBG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Electroneutral ammonium transport by basolateral rhesus B glycoprotein. (PubMed id 15284342)1, 2, 9 Ludewig U. (J. Physiol. (Lond.) 2004)
    2. Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals. (PubMed id 11024028)1, 2, 9 Liu Z.... Huang C.-H. (J. Biol. Chem. 2001)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. (PubMed id 15611082)1, 2 Lopez C.... Colin Y. (J. Biol. Chem. 2005)
    6. Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. (PubMed id 15929723)1, 2 Zidi-Yahiaoui N.... Ripoche P. (Biochem. J. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. (PubMed id 10852913)1, 3 Liu Z....Huang C.-H. (J. Biol. Chem. 2000)
    10. RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels. (PubMed id 19357182)1, 9 Brown A.C....Toye A.M. (Am. J. Physiol. Renal Physiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57127 HGNC: 14572 AceView: RHBG Ensembl:ENSG00000132677 euGenes: HUgn57127
    ECgene: RHBG H-InvDB: RHBG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHBG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RHBG gene:
    Search GeneIP for patents involving RHBG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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