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RHBDL2 Gene

protein-coding   GIFtS: 50
GCID: GC01M039351

Rhomboid, Veinlet-Like 2 (Drosophila)

(Previous names: rhomboid (veinlet, Drosophila)-like 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rhomboid, Veinlet-Like 2 (Drosophila)1 2     Rhomboid Protease 22
Rhomboid (Veinlet, Drosophila)-Like 21 2     Rhomboid-Related Protein 22
Rhomboid-Like Protein 22 3     EC 3.4.21.1053
RRP22 3     

External Ids:    HGNC: 160831   Entrez Gene: 549332   Ensembl: ENSG000001583157   OMIM: 6089625   UniProtKB: Q9NX523   

Export aliases for RHBDL2 gene to outside databases

Previous GC identifers: GC01M039276 GC01M038359 GC01M038815 GC01M038765 GC01M039021 GC01M039124 GC01M037469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHBDL2 Gene:
The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family
contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both
prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is
thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including
ephrin B2 and ephrin B3. (provided by RefSeq, Jul 2008)

GeneCards Summary for RHBDL2 Gene:
RHBDL2 (rhomboid, veinlet-like 2 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is RHBDL1.

UniProtKB/Swiss-Prot: RHBL2_HUMAN, Q9NX52
Function: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides
from their membrane anchors. Known substrate: EFNB3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHBDL2 gene promoter:
         Bach1   Roaz   NF-AT   NF-AT4   POU2F1   NF-AT2   POU2F1a   NF-AT3   MRF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHBDL2 promoter sequence
   Search Chromatin IP Primers for RHBDL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHBDL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p35.1

RHBDL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHBDL2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M039351:  view genomic region     (about GC identifiers)

Start:
39,351,479 bp from pter      End:
39,407,471 bp from pter
Size:
55,993 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RHBL2_HUMAN, Q9NX52 (See protein sequence)
Recommended Name: Rhomboid-related protein 2  
Size: 303 amino acids; 34021 Da
Sequence caution: Sequence=AAH13103.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91168.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RNT3 B9EH75 Q6P175 Q8NER8 Q96E02
Alternative splicing: 2 isoforms:  Q9NX52-1   Q9NX52-3   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHBDL2: NX_Q9NX52

Explore proteomics data for RHBDL2 at MOPED

Post-translational modifications: 

  • Proteolytic processing of the proenzyme produces a N-terminal fragment (NTF) and a C-terminal fragment (CTF). The
    processing is required for activation of the protease1
  • Modification sites at neXtProt

  • See RHBDL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060291.2  
    ENSEMBL proteins: 
     ENSP00000289248   ENSP00000441097   ENSP00000362076   ENSP00000439227   ENSP00000362081  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR022764 Peptidase_S54_rhomboid_dom
     IPR002610 Peptidase_S54_rhomboid
     IPR017213 Peptidase_S54_rhomboid_met

    Graphical View of Domain Structure for InterPro Entry Q9NX52

    ProtoNet protein and cluster: Q9NX52

    1 Blocks protein domain: IPB002610 Rhomboid-like protein

    UniProtKB/Swiss-Prot: RHBL2_HUMAN, Q9NX52
    Similarity: Belongs to the peptidase S54 family


    Find genes that share domains with RHBDL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHBL2_HUMAN, Q9NX52
    Function: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides
    from their membrane anchors. Known substrate: EFNB3
    Catalytic activity: Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine
    that are contributed by different transmembrane domains

         Enzyme Number (IUBMB): EC 3.4.21.1051

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IDA19850051
         
    Find genes that share ontologies with RHBDL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RHBDL2:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RHBDL2

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    miRTarBase miRNAs that target RHBDL2:
    hsa-mir-124-3p (MIRT022548)

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    hsa-miR-3163 hsa-miR-361-5p hsa-miR-376b hsa-miR-561 hsa-miR-376a hsa-miR-374a* hsa-miR-144 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidRHBDL2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHBL2_HUMAN, Q9NX52: Rhomboid-related protein 2, C-terminal fragment: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA19850051
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RHBDL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHBDL2
    Interactions:

        Search GeneGlobe Interaction Network for RHBDL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for RHBDL2 (Q9NX523 ENSP000002892484) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNB2P527993, ENSP000002453234I2D: score=1 STRING: ENSP00000245323
    EFNB3Q157683, ENSP000002260914I2D: score=2 STRING: ENSP00000226091
    POP4ENSP000002217704STRING: ENSP00000221770
    SRFENSP000002653544STRING: ENSP00000265354
    ID2ENSP000002340914STRING: ENSP00000234091
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with RHBDL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHBDL2 (RHBL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHBDL2 gene: 
    NM_017821.3  

    Unigene Cluster for RHBDL2:

    Rhomboid, veinlet-like 2 (Drosophila)
    Hs.524626  [show with all ESTs]
    Unigene Representative Sequence: AK097621
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289248 ENST00000540558(uc001ccv.3) ENST00000372985 ENST00000538156
    ENST00000372990(uc010oin.1 uc010oio.1 uc001ccu.1)
    miRNA
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    hsa-miR-3163 hsa-miR-361-5p hsa-miR-376b hsa-miR-561 hsa-miR-376a hsa-miR-374a* hsa-miR-144 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidRHBDL2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat RHBDL2

    Additional mRNA sequence: 

    AK097621.1 AK294115.1 AY126343.1 BC013103.1 BC137108.1 BC137110.1 BC144476.1 BC144477.1 

    8 DOTS entries:

    DT.121348336  DT.87016578  DT.91938592  DT.102822514  DT.86849383  DT.65286529  DT.102822513  DT.95309954 

    Selected AceView cDNA sequences (see all 538):

    BF001242 AW196351 AA505988 BQ777715 BM312296 AI419602 NM_017821 CR620174 
    NM_022157 AI148118 BM906174 R35574 AA165138 BU786953 CB160441 CA307952 
    N76843 AW513447 BC016668 BM972065 BE467375 AA424478 BF061588 BQ128073 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHBDL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTCAAGAC
    RHBDL2 Expression
    About this image


    RHBDL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
    RHBDL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHBDL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524626
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RHBDL2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhbdl21 , 5 rhomboid, veinlet-like 2 (Drosophila)1, 5 84.44(n)1
    84.44(a)1
      4 (57.42 cM)5
    2307261  NM_183163.21  NP_898986.21 
     1237878745 
    lizard
    (Anolis carolinensis)
    Reptilia RHBDL26
    rhomboid, veinlet-like 2 (Drosophila)
    68(a)
    1 ↔ 1
    GL343426.1(764151-768701)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rhbdl21 rhomboid, veinlet-like 2 70.83(n)
    74.62(a)
      549275  NM_001016521.2  NP_001016521.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555332 similar to rhomboid, veinlet-like 2 (Drosophila) 76.31(n)   394179  BC048048.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rho-66
    rhomboid-6
    27(a)
    1 ↔ 1
    2L(12130516-12133367)
    worm
    (Caenorhabditis elegans)
    Secernentea rom-11 rom-1 51.85(n)
    40.89(a)
      184989  NM_065628.2  NP_498029.2 


    ENSEMBL Gene Tree for RHBDL2 (if available)
    TreeFam Gene Tree for RHBDL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHBDL2 gene
    RHBDL12  RHBDL32  
    2 SIMAP similar genes for RHBDL2 using alignment to 3 protein entries:     RHBL2_HUMAN (see all proteins):
    RHBDL1    RHBDL3

    Find genes that share paralogs with RHBDL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHBDL2 (see all 1212)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130073321,2
    C--39366727(+) AATAGATAA/-  
            
    ATAAA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs588232541,2
    C--39366728(+) ATAAA-/TAAA  
            
    ATTTT
    1 -- int11Minor allele frequency- TAAA:0.00NA 2
    rs558668491,2
    C--39368097(+) TTTTT-/TGAGAT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs589199881,2
    C--39370155(+) AAAAA-/ATTATT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs351859711,2
    C--39374186(+) TCTCC-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA 4
    rs108885931,2
    C,F,A,H--39394114(+) CGGCCA/C/TTGTTT 1 -- int15NS EA NA 422
    rs353278271,2
    C--39408362(+) AAAAA-/A/AA  
            
    AAAAA
    1 -- us2k11NA 2
    rs1907048721,2
    --39409387(+) CCAAGA/GGGTTG 1 -- us2k10--------
    rs1815430641,2
    --39409432(+) CTAGCA/CTGGAT 1 -- us2k10--------
    rs1382192871,2
    C--39409450(+) TGAGAA/CCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RHBDL2 (39351479 - 39407471 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RHBDL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435884CNV Deletion17901297
    nsv518731CNV Loss19592680
    nsv871872CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608962    OMIM disorders: --


    Find genes that share disorders with RHBDL2           About GenesLikeMe

    Genetic Association Database (GAD): RHBDL2
    Human Genome Epidemiology (HuGE) Navigator: RHBDL2 (1 document)

    Export disorders for RHBDL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHBDL2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with RHBDL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2. (PubMed id 15047175)1, 2, 9 Pascall J.C. and Brown K.D. (Biochem. Biophys. Res. Commun. 2004)
    2. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1, 4 Stolk L....Lunetta K.L. (Nat. Genet. 2012)
    3. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    4. The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity. (PubMed id 19850051)1, 2 Lei X. and Li Y.M. (J. Mol. Biol. 2009)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases. (PubMed id 11672525)1, 2 Urban S.... Freeman M. (Cell 2001)
    9. Mammalian EGF receptor activation by the rhomboid protease RHBDL2. (PubMed id 21494248)1 Adrain C....Freeman M. (EMBO Rep. 2011)
    10. Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing. (PubMed id 21833011)1 Cheng T.L....Wu H.L. (J. Invest. Dermatol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54933 HGNC: 16083 AceView: MYCBPandRHBDL2andRRAGCandGJA10 Ensembl:ENSG00000158315 euGenes: HUgn54933
    ECgene: RHBDL2 H-InvDB: RHBDL2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHBDL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for RHBDL2 gene:
    Search GeneIP for patents involving RHBDL2

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