Aliases for RHBDL2 Gene
External Ids for RHBDL2 Gene
Previous GeneCards Identifiers for RHBDL2 Gene
The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
GeneCards Summary for RHBDL2 Gene
RHBDL2 (Rhomboid Like 2) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is RHBDL1.
UniProtKB/Swiss-Prot for RHBDL2 Gene
Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.