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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RHBDL1 Gene

protein-coding GIFtS: 51
GCID: GC16P000725

rhomboid, veinlet-like 1 (Drosophila)

(Previous names: rhomboid (veinlet, Drosophila)-like )
(Previous symbol: RHBDL)

Explore 2 diseases affiliated with
RHBDL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rhomboid, Veinlet-Like 1 (Drosophila)¹ ²		EC 3.4.21.105³ ⁸
RHBDL¹ ² ³ ⁵		Rhomboid (Veinlet, Drosophila)-Like¹
RRP¹ ² ³ ⁵		Rhomboid, Drosophila, Homolog Of²
Rhomboid-Like Protein 1² ³		Rhomboid-Related Protein 1²

External Ids:	HGNC: 10007¹	Entrez Gene: 9028²	Ensembl: ENSG00000103269⁷	OMIM: 603264⁵	UniProtKB: O75783³

Export aliases for RHBDL1 gene to outside databases

Previous GC identifers: GC16P000665 GC16P000666 GC16P000650

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RHBL1_HUMAN, O75783

Function: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides

from their membrane anchors (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHBDL1 gene promoter:
Sp1 p53 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHBDL1 promoter sequence

Search SABiosciences Chromatin IP Primers for RHBDL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHBDL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

RHBDL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHBDL1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P000725: view genomic region (about GC identifiers)

Start:	725,666 bp from pter	End:	728,268 bp from pter
Size:	2,603 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHBL1_HUMAN, O75783 (See protein sequence)

Recommended Name: Rhomboid-related protein 1

Size: 438 amino acids; 48314 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: A2IDC0 A2IDC1 Q0VAX4 Q9NQ85

Alternative splicing: 2 isoforms: O75783-1 O75783-2

Explore the universe of human proteins at neXtProt for RHBDL1: NX_O75783

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75783

2 DME Specific Peptides for RHBDL1 (O75783)

GRAVWLRF

GVPLEMVHG

RHBDL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003952.1

ENSEMBL proteins:

ENSP00000344206 ENSP00000455608 ENSP00000219551

Human Recombinant Protein Products for RHBDL1:

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	Uscn Proteins for RHBDL1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005887	integral to plasma membrane	TAS	9662444
GO:0016020	membrane	TAS	9662444
GO:0016021	integral to membrane	--	--

RHBDL1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RHBDL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RHBDL1 for domains About GeneDecksing

4 InterPro domains/families:

IPR011992 EF-hand-like_dom

IPR022764 Peptidase_S54_rhomboid_dom

IPR002610 Peptidase_S54_rhomboid

IPR017213 Peptidase_S54_rhomboid_met

Graphical View of Domain Structure for InterPro Entry O75783

ProtoNet protein and cluster: O75783

1 Blocks protein family: IPB002610 Rhomboid-like protein

UniProtKB/Swiss-Prot: RHBL1_HUMAN, O75783

Similarity: Belongs to the peptidase S54 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RHBL1_HUMAN, O75783

Function: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides

from their membrane anchors (By similarity)

Catalytic activity: Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that

are contributed by different transmembrane domains

Enzyme Number (IUBMB): EC 3.4.21.105¹ ²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--

RHBDL1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RHBDL1:

Decreased Wnt reporter activit

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RHBDL1

miRNA Products:		OriGene 3'-UTR Clone: RHBDL1 Browse MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate RHBDL1:
		hsa-miR-24
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHBDL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RHBDL1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RHBDL1 (ENSP00000219551⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZWINT	ENSP00000363055⁴	STRING: ENSP00000363055

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007165	signal transduction	TAS	9662444

RHBDL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RHBDL1
Search CenterWatch for drugs/clinical trials and news about RHBDL1 / RHBL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RHBDL1 gene:

NM_003961.1

Unigene Cluster for RHBDL1:

Rhomboid, veinlet-like 1 (Drosophila)

Hs.137572 [show with all ESTs]

Unigene Representative Sequence: AK294136

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000352681(uc002cir.1) ENST00000561556 ENST00000450775(uc010uun.1)

ENST00000219551(uc002cis.1)

miRNA Products:		OriGene 3'-UTR Clone: RHBDL1 Browse OriGene MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate RHBDL1:
		hsa-miR-24
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against RHBDL1

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		GenScript: all cDNA clones in your preferred vector: RHBDL1 (NM_003961)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHBDL1

Additional cDNA sequence:

AJ272344.1 AK294136.1 BC120874.2 BC120875.2 Y17108.1

3 DOTS entries:

DT.75120768 DT.75159107 DT.95265383

17 AceView cDNA sequences:

BX109654 Y17108 BI822562 NM_003961 BM719830 AJ272344 BM717565 BI667844

BI545043 BI544995 BI600093 BQ067866 AI343266 BQ188710 AI652564 AI961823

AW166279

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RHBDL1 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b
SP1:			-																-
SP2:			-				-												-
SP3:																			-
SP4:

ECgene alternative splicing isoforms for RHBDL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHBDL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTGGCCGC

About this image

RHBDL1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RHBDL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHBDL1

SOURCE GeneReport for Unigene cluster: Hs.137572

UniProtKB/Swiss-Prot: RHBL1_HUMAN, O75783

Tissue specificity: Detected in heart, brain, skeletal muscle and kidney

SABiosciences Custom PCR Arrays for RHBDL1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RHBDL1 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rhbdl1^{1 , 5}	rhomboid, veinlet-like 1 (Drosophila)^{1, 5}	90.12(n)¹ 97.51(a)¹		17 (12.93 cM)⁵ 214951¹ NM_144816.1¹ NP_659065.1¹ 25834465⁵
chicken (Gallus gallus)	Aves	RHBDL1¹	rhomboid, veinlet-like 1 (Drosophila)	87.17(n) 93.07(a)		429205 XM_426761.3 XP_426761.3
lizard (Anolis carolinensis)	Reptilia	RHBDL1⁶	--	92(a)	1 ↔ 1	AAWZ02037242(1540-16582)
zebrafish (Danio rerio)	Actinopterygii	LOC100538101¹	rhomboid-related protein 1-like	77.1(n) 82.26(a)		100538101 XM_003201347.1 XP_003201395.1
fruit fly (Drosophila melanogaster)	Insecta	stet⁶ ru⁶ (see all 4)	roughoid (see all 4)	29(a) 28(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3L(1475438-1489547) 3L(1370628-1387437)
worm (Caenorhabditis elegans)	Secernentea	rom-1⁶	Rhomboid-related protein 1	26(a)	1 → many	III(4907190-4908786)

ENSEMBL Gene Tree for RHBDL1 (if available)
TreeFam Gene Tree for RHBDL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RHBDL1 gene

RHBDL2² RHBDL3²

2 SIMAP similar genes for RHBDL1 using alignment to 3 protein entries: RHBL1_HUMAN (see all proteins):

RHBDL3 RHBDL2

RHBDL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1045763^1,2	C,F,O,A,H	--	724084(+)	`GAGGAC/TCGGAG`	2	--	us2k¹ ut3¹		27		MN NS EA NA	3142
rs143795227^1,2		--	724152(+)	`AGACAA/GCTTGC`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs117326982^1,2	F	--	724238(+)	`CTGTTC/ATGAGG`	2	--	ds500¹ us2k¹		1		NA	120
rs146373236^1,2		--	724260(+)	`TGCATA/GTGGCC`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs12447233^1,2	C,F,A,H	--	724307(+)	`GCCCAG/ATGTCC`	2	--	us2k¹ ds500¹		9		NA WA EA	550
rs117940562^1,2		--	724368(+)	`GCGCCC/TGGCAT`	2	--	ds500¹ us2k¹		1		NA	120
rs145420787^1,2		--	724547(+)	`GAACGG/TGGTGA`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs181605869^1,2		--	724584(+)	`AGGATA/GGGCCA`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs3830141^1,2	C,F,A,H	--	724633(-)	`GTCCCG/AAGAAG`	2	--	us2k¹ ds500¹		23		EA NS NA WA	3446
rs186785588^1,2		--	724634(+)	`TTCTCC/GGGACC`	2	--	ds500¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RHBDL1 (725666 - 728268 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for RHBDL1
9 CNVs: 49727 29986 49728 3987 29982 5329 30732 29983 29985

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHBDL1

DNA2.0 Custom Variant and Variant Library Synthesis for RHBDL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RHBDL1 for disorders           About GeneDecksing

OMIM gene information: 603264    OMIM disorders: --

2 diseases for RHBDL1:    About MalaCards

leber hereditary optic neuropathy neuropathy

1 disease from the University of Copenhagen DISEASES database for RHBDL1:

Leber hereditary optic neuropathy

Export disorders for RHBDL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RHBDL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RHBDL1)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of a mammalian cDNA encoding a protein with high sequence similarity to the Drosophila regulatory protein Rhomboid. (PubMed id 9662444)^{1, 2, 3, 9} Pascall J.C. and Brown K.D. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)^{1, 2} Daniels R.J....Higgs D.R. (2001)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9028	HGNC: 10007	AceView: RHBDL1	Ensembl:ENSG00000103269	euGenes: HUgn9028
ECgene: RHBDL1	H-InvDB: RHBDL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RHBDL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RHBDL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RHBDL1 gene:
Search GeneIP for patents involving RHBDL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for RHBDL1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHBDL1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHBDL1
	OriGene Protein Over-expression Lysate for RHBDL1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RHBDL1		OriGene 3'-UTR Clone for RHBDL1
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	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	OriGene Custom Antibody Services for RHBDL1		OriGene Custom Protein Services for RHBDL1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHBDL1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHBDL1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHBDL1
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	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHBDL1

	GenScript Custom Purified and Recombinant Proteins Services for RHBDL1		GenScript cDNA clones with any tag delivered in your preferred vector for RHBDL1
	GenScript Custom Assay Services for RHBDL1		GenScript Custom Superior Antibodies Services for RHBDL1
	GenScript Custom overexpressing Cell Line Services for RHBDL1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in RHBDL1 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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RHBDL1 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHBDL1

	SwitchGear 3'UTR luciferase reporter plasmids for RHBDL1
	SwitchGear Promoter luciferase reporter plasmids for RHBDL1

Search ThermoFisher Antibodies for RHBDL1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHBDL1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RHBDL1

Sirion Biotech Customized:

	stable knockdown cell line services for RHBDL1
	inducible knockdown cell line services for RHBDL1
	design and validation of potent shRNA sequences against RHBDL1
	adenovirus for potent knockdown of RHBDL1
	adenovirus for overexpression of RHBDL1
	stable overexpressing cell line services for RHBDL1
	inducible overexpressing cell line services for RHBDL1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RHBDL1 gene at Home site.

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RHBDL1 Gene

rhomboid, veinlet-like 1 (Drosophila)

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RHBDL1 Gene

rhomboid, veinlet-like 1 (Drosophila)

Aliasesfor RHBDL1 gene

Summariesfor RHBDL1 gene

Genomic Viewsfor RHBDL1 gene

Proteinsfor RHBDL1 gene

Protein Domains /Familiesfor RHBDL1 gene

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for RHBDL1 gene

Genomic Views
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for RHBDL1 gene

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for RHBDL1 gene

Pathways & Interactions
for RHBDL1 gene

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for RHBDL1 gene

Transcripts
for RHBDL1 gene

Expression
for RHBDL1 gene

Orthologs
for RHBDL1 gene

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Genomic Variants
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Disorders / Diseases
for RHBDL1 gene

Publications
for RHBDL1 gene

Intellectual Property
for RHBDL1 gene

Products
for RHBDL1 gene