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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGSL1 Gene

protein-coding   GIFtS: 39
GCID: GC01P182419

Regulator Of G-Protein Signaling Like 1

(Previous names: regulator of G-protein signalling like 1, regulator of G-protein...)
(Previous symbol: RGSL2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling Like 11 2     Regulator Of G-Protein Signalling Like 11
RGSL21 2 3     Regulator Of G-Protein Signalling Like 21
Regulator Of G-Protein Signaling Like 21 2     Regulator Of G-Protein Signaling Protein-Like2
RGSL2 3     

External Ids:    HGNC: 186361   Entrez Gene: 3532992   Ensembl: ENSG000001214467   OMIM: 6110125   UniProtKB: A5PLK63   

Export aliases for RGSL1 gene to outside databases

Previous GC identifers: GC01U900333 GC01P179696 GC01P179189 GC01P180685 GC01P180724 GC01P153658


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RGSL1 Gene: 
RGSL1 (regulator of G-protein signaling like 1) is a protein-coding gene. Diseases associated with RGSL1 include pertussis, and alzheimer's disease.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGSL1 gene promoter:
         Egr-3   NRSF form 1   CUTL1   Tal-1beta   NRSF form 2   GATA-1   AREB6   NRF-2   ITF-2   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RGSL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

RGSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGSL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P182419:  view genomic region     (about GC identifiers)

Start:
182,419,256 bp from pter      End:
182,529,734 bp from pter
Size:
110,479 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGSL_HUMAN, A5PLK6 (See protein sequence)
Recommended Name: Regulator of G-protein signaling protein-like  
Size: 1076 amino acids; 125688 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: A2A2Z0 A6PVM2 A6PVM3 Q0VAJ4 Q0VAJ5 Q6ZRL0 Q86UV0 Q9H084
Alternative splicing: 6 isoforms:  A5PLK6-1   A5PLK6-2   A5PLK6-3   A5PLK6-4   A5PLK6-5   A5PLK6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGSL1: NX_A5PLK6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A5PLK6

  • RGSL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001131141.1  
    ENSEMBL proteins: 
     ENSP00000457491   ENSP00000457748   ENSP00000458086   ENSP00000456332   ENSP00000454981  
     ENSP00000454969   ENSP00000454954   ENSP00000455349  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    RGSL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry A5PLK6

    ProtoNet protein and cluster: A5PLK6

    UniProtKB/Swiss-Prot: RGSL_HUMAN, A5PLK6
    Similarity: Contains 1 RGS domain


    RGSL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGSL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGSL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGSL1 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGSL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGSL1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--

    RGSL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGSL1 (RGSL)

    Search CenterWatch for drugs/clinical trials and news about RGSL1 / RGSL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGSL1 gene (3 alternative transcripts): 
    NM_032267.2  NM_181572.2  NM_001137669.1  

    Unigene Cluster for RGSL1:

    Regulator of G-protein signaling like 1
    Hs.121200  [show with all ESTs]
    Unigene Representative Sequence: NM_001137669
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426890 ENST00000367561(uc021pfx.1) ENST00000427189 ENST00000443996(uc010pnu.1 uc009wxx.2)
    ENST00000294854(uc009wxw.3) ENST00000416676 ENST00000422241 ENST00000447374
    ENST00000437548 ENST00000444367 ENST00000415960 ENST00000436031 ENST00000456971
    ENST00000542961

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate RGSL1:
    hsa-miR-579 hsa-miR-501-5p hsa-miR-143 hsa-miR-664* hsa-miR-1248
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RGSL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGSL1
    Clone
    Products:
         
    OriGene clones in human, mouse for RGSL1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RGSL1 (NM_001137669)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGSL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGSL1
    Sirion Biotech Customized lentivirus for stable overexpression of RGSL1 
                         Customized lentivirus expression plasmids for stable overexpression of RGSL1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RGSL1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGSL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGSL1

    Additional mRNA sequence: 

    AF508902.1 AK302768.1 BC142944.1 

    6 DOTS entries:

    DT.40124645  DT.121388473  DT.91789265  DT.101977960  DT.121388477  DT.40312181 

    11 AceView cDNA sequences:

    AF510428 NM_032267 AL136902 AF508902 AA757244 NM_181572 BX088992 AK128152 
    BI461223 AA757084 CD557783 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTCTCCCC
    RGSL1 Expression
    About this image


    Genevestigator expression for RGSL1

    SOURCE GeneReport for Unigene cluster: Hs.121200
        SABiosciences Custom PCR Arrays for RGSL1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RGSL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGSL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RGSL1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgsl11 , 5 regulator of G-protein signaling like 11, 5 77.33(n)1
    69.81(a)1
      1 (65.43 cM)5
    2408161  NM_001243223.11  NP_001230152.11 
     1537793815 
    chicken
    (Gallus gallus)
    Aves LOC1008581341 regulator of G-protein signaling protein-like 51.24(n)
    35.43(a)
      100858134  XM_003641677.1  XP_003641725.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGSL16
    Uncharacterized protein
    39(a)
    1 ↔ 1
    AAWZ02037526(1674-15359)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5657771 regulator of G-protein signaling protein-like 44.3(n)
    32.26(a)
      565777  XM_689047.3  XP_694139.3 


    ENSEMBL Gene Tree for RGSL1 (if available)
    TreeFam Gene Tree for RGSL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2404 SNPs in RGSL1 are shown (see all 2404)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30309691,2
    C--182417334(+) gtttg-/TTTG  
            
    ttttt
    1 -- us2k10--------
    rs599930761,2
    C--182417337(+) TGTTT-/GTTT  
            
    TTGAG
    1 -- us2k11Minor allele frequency- GTTT:0.00NA 2
    rs118073081,2
    C,F,H--182417383(+) acagaG/Atctca 1 -- us2k14Minor allele frequency- A:0.16WA NA 126
    rs1883863981,2
    --182417388(+) GTCTCA/GTTCTG 1 -- us2k10--------
    rs1927057531,2
    --182417419(+) TGGCAC/TGATCT 1 -- us2k10--------
    rs1457221821,2
    --182417434(+) TCACTA/GCAAAA 1 -- us2k10--------
    rs1490029791,2
    C--182417503(+) AGGTGC/TGCAAC 1 -- us2k10--------
    rs1838277631,2
    --182417533(+) TTTGTA/GTTTTT 1 -- us2k10--------
    rs1874196911,2
    --182417579(+) GTCTCG/TAACTC 1 -- us2k10--------
    rs1438400521,2
    --182417656(+) ATCTGG/TCCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGSL1 (182419256 - 182529734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RGSL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv273261CNV Insertion20981092
    esv268729CNV Insertion20981092
    nsv825531CNV Loss20364138
    nsv528762CNV Loss19592680
    nsv825553CNV Gain20364138
    nsv825542CNV Gain20364138
    esv259830OTHER Complex20981092
    esv259800OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611012    OMIM disorders: --

    5 diseases for RGSL1:    About MalaCards
    pertussis    alzheimer's disease    prostate cancer    prostatitis
    breast cancer


    RGSL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): RGSL1
    Human Genome Epidemiology (HuGE) Navigator: RGSL1 (2 documents)

    Export disorders for RGSL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGSL1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with RGSL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Intermediate phenotypes identify divergent pathways t o Alzheimer's disease. (PubMed id 20574532)1, 4 Shulman J.M....De Jager P.L. (2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Identification of 9 novel transcripts and two RGSL genes within the hereditary prostate cancer region (HPC1) at 1q25. (PubMed id 12801632)1, 3 Silva A.P....Camargo A.A. (2003)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. Chromosome 1q25.3 copy number alterations in primary b reast cancers detected by multiplex ligation-dependent probe amplification and a llelic imbalance assays and its comparison with fluorescent in situ hybridizatio n assays. (PubMed id 23248035)1 Wiechec E....Hansen L.L. (2013)
    8. High-resolution melting analysis for mutation screeni ng of RGSL1, RGS16, and RGS8 in breast cancer. (PubMed id 21135262)1 Wiechec E....Hansen L.L. (2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas. (PubMed id 18521847)1 Wiechec E....Hansen L.L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353299 HGNC: 18636 AceView: RGSL2 Ensembl:ENSG00000121446 euGenes: HUgn353299
    ECgene: RGSL1 H-InvDB: RGSL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGSL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGSL1 gene:
    Search GeneIP for patents involving RGSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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