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Aliases for RGSL1 Gene

Aliases for RGSL1 Gene

  • Regulator Of G-Protein Signaling Like 1 2 3 5
  • Regulator Of G-Protein Signaling Like 2 2 3
  • RGSL2 3 4
  • RGSL 3 4
  • Regulator Of G-Protein Signalling Like 1 2
  • Regulator Of G-Protein Signalling Like 2 2

External Ids for RGSL1 Gene

Previous HGNC Symbols for RGSL1 Gene

  • RGSL2

Previous GeneCards Identifiers for RGSL1 Gene

  • GC01U900333
  • GC01P179696
  • GC01P179189
  • GC01P180685
  • GC01P180724
  • GC01P182419
  • GC01P153658
  • GC01P182450

Summaries for RGSL1 Gene

GeneCards Summary for RGSL1 Gene

RGSL1 (Regulator Of G-Protein Signaling Like 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGSL1 Gene

Genomics for RGSL1 Gene

Regulatory Elements for RGSL1 Gene

Enhancers for RGSL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGSL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGSL1 Gene

Chromosome:
1
Start:
182,409,192 bp from pter
End:
182,560,599 bp from pter
Size:
151,408 bases
Orientation:
Plus strand

Genomic View for RGSL1 Gene

Genes around RGSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGSL1 Gene

Proteins for RGSL1 Gene

  • Protein details for RGSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5PLK6-RGSL_HUMAN
    Recommended name:
    Regulator of G-protein signaling protein-like
    Protein Accession:
    A5PLK6
    Secondary Accessions:
    • A2A2Z0
    • A6PVM2
    • A6PVM3
    • Q0VAJ4
    • Q0VAJ5
    • Q6ZRL0
    • Q86UV0
    • Q9H084

    Protein attributes for RGSL1 Gene

    Size:
    1076 amino acids
    Molecular mass:
    125688 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RGSL1 Gene

neXtProt entry for RGSL1 Gene

Proteomics data for RGSL1 Gene at MOPED

Post-translational modifications for RGSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGSL1 Gene

Domains & Families for RGSL1 Gene

Protein Domains for RGSL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5PLK6

UniProtKB/Swiss-Prot:

RGSL_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGSL1: view

No data available for Gene Families for RGSL1 Gene

Function for RGSL1 Gene

genes like me logo Genes that share phenotypes with RGSL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGSL1 Gene

Localization for RGSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGSL1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGSL1 Gene COMPARTMENTS Subcellular localization image for RGSL1 gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for RGSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RGSL1: view

Pathways & Interactions for RGSL1 Gene

SuperPathways for RGSL1 Gene

No Data Available

Interacting Proteins for RGSL1 Gene

Gene Ontology (GO) - Biological Process for RGSL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RGSL1 Gene

Drugs & Compounds for RGSL1 Gene

No Compound Related Data Available

Transcripts for RGSL1 Gene

mRNA/cDNA for RGSL1 Gene

(25) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGSL1 Gene

Regulator of G-protein signaling like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGSL1 Gene

No ASD Table

Relevant External Links for RGSL1 Gene

GeneLoc Exon Structure for
RGSL1
ECgene alternative splicing isoforms for
RGSL1

Expression for RGSL1 Gene

mRNA expression in normal human tissues for RGSL1 Gene

mRNA differential expression in normal tissues according to GTEx for RGSL1 Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for RGSL1 Gene

This gene is overexpressed in Liver (66.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGSL1 Gene



SOURCE GeneReport for Unigene cluster for RGSL1 Gene Hs.121200

genes like me logo Genes that share expression patterns with RGSL1: view

Protein tissue co-expression partners for RGSL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RGSL1 Gene

Orthologs for RGSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGSL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGSL1 35
  • 81.82 (n)
  • 74.6 (a)
RGSL1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGSL1 35
  • 84.13 (n)
  • 76.94 (a)
RGSL1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgsl1 35
  • 77.84 (n)
  • 70.34 (a)
Rgsl1 16
Rgsl1 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGSL1 35
  • 99.35 (n)
  • 98.79 (a)
oppossum
(Monodelphis domestica)
Mammalia RGSL1 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC100858077 35
  • 52.68 (n)
  • 41.33 (a)
RGSL1 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGSL1 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC565777 35
  • 43.41 (n)
  • 29.51 (a)
Species with no ortholog for RGSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGSL1 Gene

ENSEMBL:
Gene Tree for RGSL1 (if available)
TreeFam:
Gene Tree for RGSL1 (if available)

Paralogs for RGSL1 Gene

No data available for Paralogs for RGSL1 Gene

Variants for RGSL1 Gene

Sequence variations from dbSNP and Humsavar for RGSL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12083859 - 182,453,959(+) ATAGA(G/T)ATAAT reference, missense, utr-variant-5-prime
rs647224 - 182,473,879(+) ATGTG(C/G)CAATT intron-variant, reference, missense
rs155552 -- 182,455,850(-) ACCTT(A/G)GGGTA intron-variant
rs166472 -- 182,547,384(-) TCCCC(C/T)ACATC intron-variant
rs169155 -- 182,478,877(+) aaaag(A/G)ctatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGSL1 Gene

Variant ID Type Subtype PubMed ID
esv259800 OTHER Complex 20981092
esv268729 CNV Insertion 20981092
esv273261 CNV Insertion 20981092
nsv825531 CNV Loss 20364138
nsv825542 CNV Gain 20364138
nsv825553 CNV Gain 20364138
nsv528762 CNV Loss 19592680
esv259830 OTHER Complex 20981092

Variation tolerance for RGSL1 Gene

Gene Damage Index Score: 12.44; 94.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGSL1 Gene

HapMap Linkage Disequilibrium report
RGSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGSL1 Gene

Disorders for RGSL1 Gene

Relevant External Links for RGSL1

Genetic Association Database (GAD)
RGSL1
Human Genome Epidemiology (HuGE) Navigator
RGSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGSL1

No disorders were found for RGSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGSL1 Gene

Publications for RGSL1 Gene

  1. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PMID: 20574532) Shulman J.M. … De Jager P.L. (PLoS ONE 2010) 3 48 67
  2. Identification of 9 novel transcripts and two RGSL genes within the hereditary prostate cancer region (HPC1) at 1q25. (PMID: 12801632) Silva A.P. … Camargo A.A. (Gene 2003) 2 3
  3. Transcriptional regulatory network of SOX4 during myoblast differentiation. (PMID: 25969425) Jang S.M. … Choi K.H. (Biochem. Biophys. Res. Commun. 2015) 3
  4. Chromosome 1q25.3 copy number alterations in primary breast cancers detected by multiplex ligation-dependent probe amplification and allelic imbalance assays and its comparison with fluorescent in situ hybridization assays. (PMID: 23248035) Wiechec E. … Hansen L.L. (Cell Oncol (Dordr) 2013) 3
  5. High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer. (PMID: 21135262) Wiechec E. … Hansen L.L. (Cancer Epidemiol. Biomarkers Prev. 2011) 3

Products for RGSL1 Gene

Sources for RGSL1 Gene

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