Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS9BP Gene

Aliases for RGS9BP Gene

  • Regulator Of G Protein Signaling 9 Binding Protein 2 3
  • R9AP 3 4 6
  • RGS9-Anchoring Protein 3 4
  • PERRS 3 6
  • RGS9 3 6
  • Regulator Of G Protein Signalling 9 Binding Protein 2
  • Regulator Of G-Protein Signaling 9-Binding Protein 3
  • RGS9 Anchor Protein 3

External Ids for RGS9BP Gene

Previous GeneCards Identifiers for RGS9BP Gene

  • GC19P037862
  • GC19P033166
  • GC19P029669

Summaries for RGS9BP Gene

Entrez Gene Summary for RGS9BP Gene

  • The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010]

GeneCards Summary for RGS9BP Gene

RGS9BP (Regulator Of G Protein Signaling 9 Binding Protein) is a Protein Coding gene. Diseases associated with RGS9BP include bradyopsia. Among its related pathways are Signaling by GPCR and Disease.

UniProtKB/Swiss-Prot for RGS9BP Gene

  • Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS9BP Gene

Genomics for RGS9BP Gene

Regulatory Elements for RGS9BP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGS9BP Gene

Start:
32,675,407 bp from pter
End:
32,678,300 bp from pter
Size:
2,894 bases
Orientation:
Plus strand

Genomic View for RGS9BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS9BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS9BP Gene

Proteins for RGS9BP Gene

  • Protein details for RGS9BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS82-R9BP_HUMAN
    Recommended name:
    Regulator of G-protein signaling 9-binding protein
    Protein Accession:
    Q6ZS82
    Secondary Accessions:
    • Q6ZVJ6

    Protein attributes for RGS9BP Gene

    Size:
    235 amino acids
    Molecular mass:
    25148 Da
    Quaternary structure:
    • Specifically interacts with isoform RGS9-1 of RGS9. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP (By similarity).

neXtProt entry for RGS9BP Gene

Proteomics data for RGS9BP Gene at MOPED

Post-translational modifications for RGS9BP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS9BP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS9BP Gene

Domains for RGS9BP Gene

Protein Domains for RGS9BP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGS9BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZS82

UniProtKB/Swiss-Prot:

R9BP_HUMAN :
  • Q6ZS82
Family:
  • Belongs to the RGS7BP/RGS9BP family.
genes like me logo Genes that share domains with RGS9BP: view

No data available for Gene Families for RGS9BP Gene

Function for RGS9BP Gene

Molecular function for RGS9BP Gene

UniProtKB/Swiss-Prot Function: Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity).

Phenotypes for RGS9BP Gene

MGI mutant phenotypes for RGS9BP:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RGS9BP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RGS9BP Gene

Localization for RGS9BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS9BP Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS9BP Gene COMPARTMENTS Subcellular localization image for RGS9BP gene
Compartment Confidence
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RGS9BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RGS9BP: view

Pathways for RGS9BP Gene

genes like me logo Genes that share pathways with RGS9BP: view

Interacting Proteins for RGS9BP Gene

Gene Ontology (GO) - Biological Process for RGS9BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007603 phototransduction, visible light TAS --
GO:0009968 negative regulation of signal transduction IEA --
GO:0016056 rhodopsin mediated signaling pathway TAS --
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:0050908 detection of light stimulus involved in visual perception IEA --
genes like me logo Genes that share ontologies with RGS9BP: view

Transcripts for RGS9BP Gene

mRNA/cDNA for RGS9BP Gene

(15) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGS9BP Gene

Regulator of G protein signaling 9 binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS9BP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RGS9BP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS9BP Gene

No ASD Table

Relevant External Links for RGS9BP Gene

GeneLoc Exon Structure for
RGS9BP
ECgene alternative splicing isoforms for
RGS9BP

Expression for RGS9BP Gene

mRNA expression in normal human tissues for RGS9BP Gene

mRNA expression in normal human tissues for RGS9BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RGS9BP Gene

SOURCE GeneReport for Unigene cluster for RGS9BP Gene Hs.528491

genes like me logo Genes that share expressions with RGS9BP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RGS9BP Gene

Orthologs for RGS9BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS9BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS9BP 35
  • 99.43 (n)
  • 99.15 (a)
RGS9BP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS9BP 35
  • 82.7 (n)
  • 77.02 (a)
RGS9BP 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS9BP 35
  • 81.97 (n)
  • 72.53 (a)
RGS9BP 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs9bp 35
  • 82.03 (n)
  • 83.41 (a)
Rgs9bp 16
Rgs9bp 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS9BP 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs9bp 35
  • 81.72 (n)
  • 82.95 (a)
chicken
(Gallus gallus)
Aves RGS9BP 35
  • 66.97 (n)
  • 60.09 (a)
RGS9BP 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS9BP 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491544 35
  • 59.94 (n)
  • 58.26 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559232 35
  • 63.59 (n)
  • 53.92 (a)
RGS9BP 36
  • 51 (a)
OneToOne
Species with no ortholog for RGS9BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS9BP Gene

ENSEMBL:
Gene Tree for RGS9BP (if available)
TreeFam:
Gene Tree for RGS9BP (if available)

Paralogs for RGS9BP Gene

No data available for Paralogs for RGS9BP Gene

Variants for RGS9BP Gene

Sequence variations from dbSNP and Humsavar for RGS9BP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_032333 -

Structural Variations from Database of Genomic Variants (DGV) for RGS9BP Gene

Variant ID Type Subtype PubMed ID
dgv3838n71 CNV Loss 21882294

Relevant External Links for RGS9BP Gene

HapMap Linkage Disequilibrium report
RGS9BP
Human Gene Mutation Database (HGMD)
RGS9BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS9BP Gene

Disorders for RGS9BP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RGS9BP Gene including...

Search for RGS9BP Gene in MalaCards »

(1) OMIM Diseases for RGS9BP Gene (607814)

UniProtKB/Swiss-Prot

R9BP_HUMAN
  • Prolonged electroretinal response suppression (PERRS) [MIM:608415]: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones. {ECO:0000269 PubMed:14702087}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RGS9BP

Genetic Association Database (GAD)
RGS9BP
Human Genome Epidemiology (HuGE) Navigator
RGS9BP
genes like me logo Genes that share disorders with RGS9BP: view

Publications for RGS9BP Gene

  1. Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. (PMID: 14702087) Nishiguchi K.M. … Dryja T.P. (Nature 2004) 3 4
  2. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M. … Ramoni M.F. (Circulation 2009) 3 48
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  4. R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. (PMID: 12119397) Hu G. … Wensel T.G. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP. (PMID: 12560335) Hu G. … Wensel T.G. (J. Biol. Chem. 2003) 3

Products for RGS9BP Gene

Sources for RGS9BP Gene

Back to Top

Content