Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGS9 Gene

protein-coding GIFtS: 61
GCID: GC17P063133

regulator of G-protein signaling 9

(Previous name: regulator of G-protein signalling 9 )

Explore 10 diseases affiliated with
RGS9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 9¹ ²
PERRS¹ ² ⁵
RGS9L¹ ²
Regulator Of G-Protein Signalling 9¹ ²
MGC111763¹
MGC26458¹

External Ids:	HGNC: 10004¹	Entrez Gene: 8787²	Ensembl: ENSG00000108370⁷	OMIM: 604067⁵	UniProtKB: O75916³

Export aliases for RGS9 gene to outside databases

Previous GC identifers: GC17M065188 GC17M068254 GC17P063551 GC17P063683 GC17P060564 GC17P058525

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS9:

This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways

by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells

and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in

bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by

RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: RGS9_HUMAN, O75916

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the

recovery phase of visual transduction (By similarity)

Gene Wiki entry for RGS9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGS9 gene promoter:
NF-YB CBF-B CBF-A NF-YA HSF2 CP1A NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS9 promoter sequence

Search SABiosciences Chromatin IP Primers for RGS9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24 Ensembl cytogenetic band: 17q24.1 HGNC cytogenetic band: 17q24

RGS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS9 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P063133: view genomic region (about GC identifiers)

Start:	63,133,456 bp from pter	End:	63,223,821 bp from pter
Size:	90,366 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGS9_HUMAN, O75916 (See protein sequence)

Recommended Name: Regulator of G-protein signaling 9

Size: 674 amino acids; 76966 Da

Subunit: Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the

heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of isoform 3 of RGS9 (RGS9-1), Gbeta5

(GNB5) and RGS9BP (Probable)

Subcellular location: Isoform 3: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via

its interaction with RGS9BP (By similarity)

Sequence caution: Sequence=AAC25430.1; Type=Erroneous initiation;

Secondary accessions: A8K3C0 O75573 Q696R2 Q8TD64 Q8TD65 Q9HC32 Q9HC33

Alternative splicing: 5 isoforms: O75916-1 O75916-2 O75916-3 O75916-4 O75916-5

Explore the universe of human proteins at neXtProt for RGS9: NX_O75916

Post-translational modifications:

Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition (By

similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75916

RGS9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001075424.1 NP_001159405.1 NP_003826.2

ENSEMBL proteins:

ENSP00000405814 ENSP00000463410 ENSP00000396329 ENSP00000262406

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: RGS9 OriGene Custom Protein Services for RGS9
	GenScript Custom Purified and Recombinant Proteins Services for RGS9
	Novus Biologicals RGS9 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RGS9

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IBA	--
GO:0005834	heterotrimeric G-protein complex	IEA	--
GO:0005886	plasma membrane	IBA	--

RGS9 for ontologies About GeneDecksing

RGS9 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RGS9
	Browse R&D Systems for Antibodies
	OriGene Antibodies: RGS9 OriGene Custom Antibody Services for RGS9
	GenScript Custom Superior Antibodies Services for RGS9
	Novus Biologicals RGS9 Antibodies
	Abcam antibodies for RGS9
	Uscn Antibodies for RGS9
	ThermoFisher Antibodies for RGS9

Assay Products for RGS9:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RGS9
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RGS9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGS9 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR024066 Regulat_G_prot_signal_dom1

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR000342 Regulat_G_prot_signal

IPR016137 Regulat_G_prot_signal_superfam

IPR000591 DEP_dom

Graphical View of Domain Structure for InterPro Entry O75916

ProtoNet protein and cluster: O75916

3 Blocks protein families:

IPB000342 Regulator of G-protein signalling (RGS) protein signature

IPB000591 Pleckstrin putative G-protein interacting domain

IPB001770 Gamma G-protein (transducin) signature

UniProtKB/Swiss-Prot: RGS9_HUMAN, O75916

Domain: In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments

Similarity: Contains 1 DEP domain

Similarity: Contains 1 G protein gamma domain

Similarity: Contains 1 RGS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RGS9_HUMAN, O75916

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the

recovery phase of visual transduction (By similarity)

Genatlas biochemistry entry for RGS9:

negative regulator of G protein signaling 9,55kDa,functioning as GTPase activating protein for G proteins alpha i and q

subunits,expressed in rod outer segments and cones,controlling PDE activity through regulation of transducin,C elegans

EGL-10 and yeast SST2 homolog

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RGS9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS9
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS9:
		hsa-miR-3910 hsa-miR-124 hsa-miR-4325 hsa-miR-506 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: RGS9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS9 (see all 7) OriGene shRNA RFP: RGS9 OriGene siRNA: RGS9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS9

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RGS9

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS9 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS9 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RGS9 (NM_001165933)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RGS9
		Search LifeMap BioReagents cell lines for RGS9

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS9

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IEA	--
GO:0005096	GTPase activator activity	IBA	--
GO:0032403	protein complex binding	IEA	--

RGS9 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Rgs9^tm1Citb for RGS9
     3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rgs9):

behavior/neurological

nervous system

vision/eye

RGS9 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Visual signal transduction- Rods

	Visual signal transduction- Rods	1.00			Visual signal transduction- Cones	0.39
	Phototransduction	0.44

G-AlphaQ Signaling

G-AlphaQ Signaling

1.00

G-AlphaI Signaling

0.47

Calcium Regulation in the Cardiac Cell

Calcium Regulation in the Cardiac Cell

1.00

Myometrial Relaxation and Contraction Pathways

0.43

Visual Cycle in Retinal Rods

Visual Cycle in Retinal Rods

1.00

Activation of cAMP-Dependent PKA

cAMP Pathway

0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS9

	cAMP Pathway
	Visual Cycle in Retinal Rods
	G-AlphaI Signaling
	G-AlphaQ Signaling

4 BioSystems Pathways for RGS9

	Calcium Regulation in the Cardiac Cell
	Myometrial Relaxation and Contraction Pathways
	Visual signal transduction- Cones
	Visual signal transduction- Rods

1 Kegg Pathway (Kegg details for RGS9):

Phototransduction

RGS9 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RGS9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/41 Interacting proteins for RGS9 (O75916^{2, 3} ENSP00000262406⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAT1	P11488³, ENSP00000232461⁴	I2D: score=2 STRING: ENSP00000232461
H3F3A	P84243³	I2D: score=1
H3F3B	P84243³	I2D: score=1
GNB5	O14775³, ENSP00000261837⁴	I2D: score=1 STRING: ENSP00000261837
GNAT2	ENSP00000251337⁴	STRING: ENSP00000251337

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007212	dopamine receptor signaling pathway	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0007601	visual perception	IEA	--
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	TAS	9765512
GO:0035556	intracellular signal transduction	IEA	--

RGS9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RGS9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGS9
2 Novoseek chemical compound relationships for RGS9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	44.3	1	9459445 (1)
cgmp	43.8	1	9560279 (1)

Search CenterWatch for drugs/clinical trials and news about RGS9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGS9 gene (3 alternative transcripts):

NM_001081955.2 NM_001165933.1 NM_003835.3

Unigene Cluster for RGS9:

Regulator of G-protein signaling 9

Hs.664380 [show with all ESTs]

Unigene Representative Sequence: NM_003835

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000583473 ENST00000443584(uc021ubw.1 uc010dem.3) ENST00000584234

ENST00000449996(uc002jfd.3 uc002jfe.3) ENST00000262406 ENST00000581175

ENST00000577186 ENST00000577595(uc002jfg.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RGS9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS9
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS9:
		hsa-miR-3910 hsa-miR-124 hsa-miR-4325 hsa-miR-506 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: RGS9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS9 (see all 7) OriGene shRNA RFP: RGS9 OriGene siRNA: RGS9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS9

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS9 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS9 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RGS9 (NM_001165933)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS9

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RGS9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS9

Additional cDNA sequence:

AF071476.1 AF493932.1 AF493933.1 AK289876.1 AK290535.1 AK301719.1 AK309061.1 AY585190.1

AY585191.1 BC022504.1 BC096843.1

5 DOTS entries:

DT.306203 DT.92419074 DT.100711337 DT.120927033 DT.91649939

24/43 AceView cDNA sequences (see all 43):

CR613211 BQ632133 AY585191 BF448133 AY585190 CD105605 BM931191 AF071476

BQ053370 AI439782 BX348648 CB565899 BG014093 AA678971 BQ053968 AA915931

BQ189679 BM805389 CB565898 AA653129 BM922571 AL523317 BC022504 AI420112

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RGS9 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b
SP1:											-																-
SP2:											-														-		-
SP3:
SP4:

ECgene alternative splicing isoforms for RGS9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGS9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGACCAGAA

About this image

RGS9 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovary

Pancreas

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RGS9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGS9

SOURCE GeneReport for Unigene cluster: Hs.664380

UniProtKB/Swiss-Prot: RGS9_HUMAN, O75916

Tissue specificity: Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus

accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is

expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors)

SABiosciences Custom PCR Arrays for RGS9

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RGS9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RGS9 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RGS9¹	regulator of G-protein signaling 9	72.26(n) 72.31(a)		417433 XM_415685.3 XP_415685.3
lizard (Anolis carolinensis)	Reptilia	RGS9⁶	--	64(a)	1 ↔ 1	GL343260.1(1272128-1346087)
African clawed frog (Xenopus laevis)	Amphibia	rgs9-A-prov²	regulator of G-protein signalling 9	86.8(n)		AB038437.1
zebrafish (Danio rerio)	Actinopterygii	zgc73189²	hypothetical protein MGC73189	72.38(n)		393803 BC060915.1
fruit fly (Drosophila melanogaster)	Insecta	CG42450⁶	--	16(a)	1 → many	X(18707657-18724297)
worm (Caenorhabditis elegans)	Secernentea	eat-16⁶	EATing: abnormal pharyngeal pumping family member ...	29(a)	1 → many	I(9722541-9725602)

ENSEMBL Gene Tree for RGS9 (if available)
TreeFam Gene Tree for RGS9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RGS9 gene

RGS14² RGS11² RGS12² RGS10² RGS7² RGS6²

17 SIMAP similar genes for RGS9 using alignment to 5 protein entries: RGS9_HUMAN (see all proteins):

RGS11 RGS20 RGS10 RGS17 RGS18 RGS5

RGS6 RGS7 RGS4 RGS1 RGS19 RGS13

RGS2 RGS3 RGS21 RGS16 RGS8

RGS9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121908449^1,2	C	pathogenic	83228755(+)	`AACGAT/CGGGCC`	6	/R /W	mis¹		1		EU	1323
rs299821^1,2	C,F,A,H,	--	58524107(-)	`GAAAGC/ATATGG`	3	--	us2k¹		20		NS EA NA	2642
rs78899517^1,2	F,	--	58525429(+)	`ATTTTT/CCAATT`	3	--	us2k¹		1		WA	118
rs73345861^1,2	C,F,	--	58526310(+)	`GGGAGG/CTGAAA`	3	--	int¹		4		WA CSA EA	242
rs72850378^1,2	C,F,	--	58526397(+)	`GACGAC/G/TCAGAT`	3	--	int¹		2		NA EA	240
rs73345863^1,2	C,F,	--	58526413(+)	`ATTGCC/TATTTT`	3	--	int¹		3		WA	122
rs78613898^1,2	F,	--	58526812(+)	`CCTCCC/TACCCG`	3	--	int¹		1		WA	118
rs76885698^1,2		--	58526835(+)	`ACAGCG/ATAGTG`	3	--	int¹		1		NA	120
rs75483784^1,2		--	58527691(+)	`CCACCC/TTGTCT`	3	--	int¹		0	--	--	--	--
rs112066203^1,2		--	58527782(+)	`CTCCCG/CCTCCT`	3	--	int¹		1		CSA	1

HapMap Linkage Disequilibrium report for RGS9 (63133456 - 63223821 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RGS9: --
Human Gene Mutation Database (HGMD): RGS9

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS9

DNA2.0 Custom Variant and Variant Library Synthesis for RGS9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RGS9 for disorders           About GeneDecksing

OMIM gene information: 604067
OMIM disorders: 608415
UniProtKB/Swiss-Prot: RGS9_HUMAN, O75916

Defects in RGS9 are a cause of prolonged electroretinal response suppression (PERRS) [MIM:608415]; also known

as bradyopsia. PERRS is characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones

10 diseases for RGS9: About MalaCards

bradyopsia retinitis tardive dyskinesia retinitis pigmentosa

squamous cell carcinoma parkinson's disease pharyngitis atherosclerosis

schizophrenia carcinoma

Genetic Association Database (GAD): RGS9
Human Genome Epidemiology (HuGE) Navigator: RGS9 (6 documents)

Export disorders for RGS9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RGS9 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with RGS9)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene. (PubMed id 9765512)^{1, 2, 3} Granneman J.G.... Cooper J. (1998)
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. (PubMed id 14702087)^{1, 2, 9} Nishiguchi K.M.... Dryja T.P. (2004)
Structure, alternative splicing, and expression of the human RGS9 gene. (PubMed id 10564809)^{1, 2, 9} Zhang K.... Baehr W. (1999)
The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. (PubMed id 14614075)^{1, 2} Martemyanov K.A.... Arshavsky V.Y. (2003)
[Analysis of GUCA1B,GNGT1 and RGS9 genes in patients with retinitis pigmentosa] (PubMed id 15901556)^{1, 4} Zhang Q.J....Guo X.M. (2002)
Novel mutations and electrophysiologic findings in RG S9- and R9AP-associated retinal dysfunction (Bradyopsia). (PubMed id 19818506)^{1, 9} Michaelides M....Webster A.R. (2010)
High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. (PubMed id 9560279)^{1, 9} Cowan C.W....Wensel T.G. (1998)
Analysis of genetic variations in the RGS9 gene and antipsychotic-induced tardive dyskinesia in schizophrenia. (PubMed id 18548510)^{1, 9} Liou Y.J....Lai I.C. (2008)
No association between regulator of G-protein signali ng 9 (RGS9) and schizophrenia in a Jewish population. (PubMed id 20016399)^{1, 9} Greenbaum L....Kohn Y. (2010)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8787	HGNC: 10004	AceView: RGS9	Ensembl:ENSG00000108370	euGenes: HUgn8787
ECgene: RGS9	Kegg: 8787	H-InvDB: RGS9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RGS9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RGS9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RGS9 gene:
Search GeneIP for patents involving RGS9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of RGS9
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for RGS9		OriGene shRNA RFP for RGS9
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS9		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS9
	OriGene Protein Over-expression Lysate for RGS9		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RGS9		OriGene 3'-UTR Clone for RGS9
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS9		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS9
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RGS9		OriGene Custom Protein Services for RGS9
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGS9
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS9
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS9
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS9
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS9
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS9

	GenScript Custom Purified and Recombinant Proteins Services for RGS9		GenScript cDNA clones with any tag delivered in your preferred vector for RGS9
	GenScript Custom Assay Services for RGS9		GenScript Custom Superior Antibodies Services for RGS9
	GenScript Custom overexpressing Cell Line Services for RGS9		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RGS9 promoter
	Search Chromatin IP Primers for RGS9
	RT² qPCR Primer Assay in human, mouse, rat RGS9
	Search GNC Networks for RGS9
	SABiosciences PCR Arrays including human, mouse, rat RGS9

Search Tocris compounds for RGS9

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RGS9 antibodies
	RGS9 lysates

	Antibodies for RGS9
	See all of Abcam's Antibodies, Kits and Proteins for RGS9
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RGS9 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RGS9

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS9

	SwitchGear 3'UTR luciferase reporter plasmids for RGS9
	SwitchGear Promoter luciferase reporter plasmids for RGS9

ThermoFisher Antibodies for RGS9

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS9

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RGS9 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RGS9 Gene

regulator of G-protein signaling 9

Aliases
for RGS9 gene

Summaries
for RGS9 gene

Genomic Views
for RGS9 gene

Proteins
for RGS9 gene

Protein Domains /
Families
for RGS9 gene

Function
for RGS9 gene

Pathways & Interactions
for RGS9 gene

Drugs & Compounds
for RGS9 gene

Transcripts
for RGS9 gene

Expression
for RGS9 gene

Orthologs
for RGS9 gene

Paralogs
for RGS9 gene

Genomic Variants
for RGS9 gene

Disorders / Diseases
for RGS9 gene

Publications
for RGS9 gene

External Searches for RGS9 gene

Genome Databases showing RGS9 gene

Other Databases showing RGS9 gene

Specialized Databases showing RGS9 gene

Intellectual Property
for RGS9 gene

Products
for RGS9 gene

View Random Gene

Advanced Search

Export list of displayed genes

RGS9 Gene

regulator of G-protein signaling 9

Aliasesfor RGS9 gene

Summariesfor RGS9 gene

Genomic Viewsfor RGS9 gene

Proteinsfor RGS9 gene

Protein Domains /Familiesfor RGS9 gene

Functionfor RGS9 gene

Pathways & Interactionsfor RGS9 gene

Drugs & Compoundsfor RGS9 gene

Transcriptsfor RGS9 gene

Expression for RGS9 gene

Orthologsfor RGS9 gene

Paralogsfor RGS9 gene

Genomic Variantsfor RGS9 gene

Disorders / Diseasesfor RGS9 gene

Publicationsfor RGS9 gene

External Searches for RGS9 gene

Genome Databases showing RGS9 gene

Other Databases showing RGS9 gene

Specialized Databases showing RGS9 gene

Intellectual Propertyfor RGS9 gene

Productsfor RGS9 gene

View Random Gene

Aliases
for RGS9 gene

Summaries
for RGS9 gene

Genomic Views
for RGS9 gene

Proteins
for RGS9 gene

Protein Domains /
Families
for RGS9 gene

Function
for RGS9 gene

Pathways & Interactions
for RGS9 gene

Drugs & Compounds
for RGS9 gene

Transcripts
for RGS9 gene

Expression
for RGS9 gene

Orthologs
for RGS9 gene

Paralogs
for RGS9 gene

Genomic Variants
for RGS9 gene

Disorders / Diseases
for RGS9 gene

Publications
for RGS9 gene

Intellectual Property
for RGS9 gene

Products
for RGS9 gene