Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS8 Gene

Aliases for RGS8 Gene

  • Regulator Of G-Protein Signaling 8 2 3 5
  • Regulator Of G-Protein Signalling 8 2

External Ids for RGS8 Gene

Previous GeneCards Identifiers for RGS8 Gene

  • GC01M180141
  • GC01M178044
  • GC01M179131
  • GC01M179855
  • GC01M179347
  • GC01M180877
  • GC01M153852

Summaries for RGS8 Gene

Entrez Gene Summary for RGS8 Gene

  • This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS8 Gene

RGS8 (Regulator Of G-Protein Signaling 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS8 Gene

  • Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).

Gene Wiki entry for RGS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS8 Gene

Genomics for RGS8 Gene

Regulatory Elements for RGS8 Gene

Genomic Location for RGS8 Gene

Chromosome:
1
Start:
182,641,816 bp from pter
End:
182,753,307 bp from pter
Size:
111,492 bases
Orientation:
Minus strand

Genomic View for RGS8 Gene

Genes around RGS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS8 Gene

Proteins for RGS8 Gene

  • Protein details for RGS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57771-RGS8_HUMAN
    Recommended name:
    Regulator of G-protein signaling 8
    Protein Accession:
    P57771
    Secondary Accessions:
    • B4DGL9
    • Q3SYD2

    Protein attributes for RGS8 Gene

    Size:
    180 amino acids
    Molecular mass:
    20917 Da
    Quaternary structure:
    • Interacts with GNAO1 (By similarity). Interacts with GNAI3.

    Three dimensional structures from OCA and Proteopedia for RGS8 Gene

    Alternative splice isoforms for RGS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS8 Gene

Proteomics data for RGS8 Gene at MOPED

Post-translational modifications for RGS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS8 Gene

Antibody Products

No data available for DME Specific Peptides for RGS8 Gene

Domains & Families for RGS8 Gene

Gene Families for RGS8 Gene

Protein Domains for RGS8 Gene

Suggested Antigen Peptide Sequences for RGS8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57771

UniProtKB/Swiss-Prot:

RGS8_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS8: view

Function for RGS8 Gene

Molecular function for RGS8 Gene

UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).

Gene Ontology (GO) - Molecular Function for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 18434541
genes like me logo Genes that share ontologies with RGS8: view
genes like me logo Genes that share phenotypes with RGS8: view

Animal Models for RGS8 Gene

MGI Knock Outs for RGS8:

Animal Model Products

miRNA for RGS8 Gene

miRTarBase miRNAs that target RGS8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS8 Gene

Localization for RGS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS8 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, dendrite. Nucleus. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250 UniProtKB:P49804}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS8 Gene COMPARTMENTS Subcellular localization image for RGS8 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
GO:0030425 dendrite ISS --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISS --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with RGS8: view

Pathways & Interactions for RGS8 Gene

genes like me logo Genes that share pathways with RGS8: view

Pathways by source for RGS8 Gene

Gene Ontology (GO) - Biological Process for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway ISS --
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IDA,IBA 18434541
genes like me logo Genes that share ontologies with RGS8: view

No data available for SIGNOR curated interactions for RGS8 Gene

Drugs & Compounds for RGS8 Gene

No Compound Related Data Available

Transcripts for RGS8 Gene

Unigene Clusters for RGS8 Gene

Regulator of G-protein signaling 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for RGS8 Gene

GeneLoc Exon Structure for
RGS8
ECgene alternative splicing isoforms for
RGS8

Expression for RGS8 Gene

mRNA expression in normal human tissues for RGS8 Gene

mRNA differential expression in normal tissues according to GTEx for RGS8 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.1), Brain - Caudate (basal ganglia) (x6.9), and Brain - Putamen (basal ganglia) (x6.6).

Protein differential expression in normal tissues from HIPED for RGS8 Gene

This gene is overexpressed in Monocytes (41.2), Retina (16.9), and Adipocyte (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS8 Gene



SOURCE GeneReport for Unigene cluster for RGS8 Gene Hs.20982

genes like me logo Genes that share expression patterns with RGS8: view

Protein tissue co-expression partners for RGS8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RGS8 Gene

Orthologs for RGS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS8 35
  • 93.06 (n)
  • 98.84 (a)
RGS8 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS8 35
  • 93.77 (n)
  • 97.98 (a)
RGS8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs8 35
  • 89.79 (n)
  • 97.69 (a)
Rgs8 16
Rgs8 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS8 35
  • 99.49 (n)
  • 99.49 (a)
RGS8 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs8 35
  • 91.52 (n)
  • 98.27 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS8 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS8 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS8 35
  • 82.27 (n)
  • 90.17 (a)
RGS8 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS8 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs8 35
  • 64.01 (n)
  • 63.3 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs8 35
  • 67.08 (n)
  • 66.26 (a)
rgs8 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6075 35
Species with no ortholog for RGS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS8 Gene

ENSEMBL:
Gene Tree for RGS8 (if available)
TreeFam:
Gene Tree for RGS8 (if available)

Paralogs for RGS8 Gene

Paralogs for RGS8 Gene

(20) SIMAP similar genes for RGS8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS8: view

Variants for RGS8 Gene

Sequence variations from dbSNP and Humsavar for RGS8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs183812 -- 182,749,075(-) tctgc(A/T)cagca intron-variant
rs184890 -- 182,749,107(-) agaca(A/C)atggg intron-variant
rs169064 -- 182,749,216(-) aagct(A/C)tgaaa intron-variant
rs169065 -- 182,746,899(-) caaaa(A/G)aTAGG intron-variant
rs171930 -- 182,749,176(-) tcata(A/T)cactg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS8 Gene

Variant ID Type Subtype PubMed ID
nsv3810 CNV Loss 18451855

Variation tolerance for RGS8 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS8 Gene

HapMap Linkage Disequilibrium report
RGS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS8 Gene

Disorders for RGS8 Gene

Relevant External Links for RGS8

Genetic Association Database (GAD)
RGS8
Human Genome Epidemiology (HuGE) Navigator
RGS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS8

No disorders were found for RGS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS8 Gene

Publications for RGS8 Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4 23 67
  2. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 23
  3. Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8. (PMID: 18834863) Fujii S. … Saitoh O. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics. (PMID: 15677457) Benians A. … Tinker A. (J. Biol. Chem. 2005) 3 23
  5. The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression. (PMID: 14675160) Masuho I. … Saitoh O. (J. Neurochem. 2004) 3 23

Products for RGS8 Gene

Sources for RGS8 Gene

Back to Top

Content