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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS8 Gene

protein-coding   GIFtS: 55
GCID: GC01M182610

Regulator Of G-Protein Signaling 8

(Previous name: regulator of G-protein signalling 8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 81 2
Regulator Of G-Protein Signalling 81 2

External Ids:    HGNC: 168101   Entrez Gene: 853972   Ensembl: ENSG000001358247   OMIM: 6071895   UniProtKB: P577713   

Export aliases for RGS8 gene to outside databases

Previous GC identifers: GC01M180141 GC01M178044 GC01M179131 GC01M179855 GC01M179347 GC01M180877 GC01M153852


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS8 Gene:
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS
domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G
protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to
GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RGS8 Gene: 
RGS8 (regulator of G-protein signaling 8) is a protein-coding gene. Diseases associated with RGS8 include q fever, and ischemia, and among its related super-pathways are G-AlphaQ Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS8_HUMAN, P57771
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By
similarity)

Gene Wiki entry for RGS8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS8 gene promoter:
         TBP   Lmo2   NF-AT   PPAR-gamma1   NF-AT4   NF-AT2   c-Myb   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS8 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

RGS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M182610:  view genomic region     (about GC identifiers)

Start:
182,615,239 bp from pter      End:
182,653,711 bp from pter
Size:
38,473 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGS8_HUMAN, P57771 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 8  
Size: 180 amino acids; 20917 Da
2 PDB 3D structures from and Proteopedia for RGS8:
2IHD (3D)        2ODE (3D)    
Secondary accessions: B4DGL9 Q3SYD2
Alternative splicing: 2 isoforms:  P57771-1   P57771-2   

Explore the universe of human proteins at neXtProt for RGS8: NX_P57771

Explore proteomics data for RGS8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P57771

  • RGS8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGS8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001095920.1  NP_203131.1  

    ENSEMBL proteins: 
     ENSP00000426289   ENSP00000258302   ENSP00000356528   ENSP00000356527   ENSP00000427076  

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    Novus Biologicals RGS8 Proteins
    Novus Biologicals RGS8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for RGS8 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--

    RGS8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry P57771

    ProtoNet protein and cluster: P57771

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS8_HUMAN, P57771
    Similarity: Contains 1 RGS domain


    RGS8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS8_HUMAN, P57771
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By
    similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
         
    RGS8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGS8 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGS8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Activation of cAMP-Dependent PKA
    cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS8
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGS8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RGS8 (ENSP000002583024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI3ENSP000003588674STRING: ENSP00000358867
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity IBA--

    RGS8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS8

    Search CenterWatch for drugs/clinical trials and news about RGS8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGS8 gene (2 alternative transcripts): 
    NM_001102450.1  NM_033345.2  

    Unigene Clusters for RGS8:

    Regulator of G-protein signaling 8
    Hs.20982  [show with all ESTs], Hs.458417  [show with all ESTs]
    Unigene Representative Sequences: AK057753, AK294660
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483095(uc010pnw.1) ENST00000258302(uc001gpm.1) ENST00000367557(uc001gpn.1)
    ENST00000367556 ENST00000491420 ENST00000508450 ENST00000515211
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS8
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    Additional mRNA sequence: 

    AF297015.1 AF300649.1 AK294660.1 AK296514.1 BC069677.1 BC069718.1 BC103865.1 BC103866.1 
    BC103867.1 

    4 DOTS entries:

    DT.95330573  DT.211223  DT.95311259  DT.95263015 

    24/29 AceView cDNA sequences (see all 29):

    BX954018 BM725999 NM_033345 BM709429 AF297015 BU733370 AF300649 BC069718 
    H17666 CB565900 AF297014 AI209102 Z39283 Z43204 BX108838 BM681011 
    BC069677 AH010175 BX281622 BG195915 R55736 BI002651 W28336 R37101 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RGS8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for RGS8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS8 expression in normal human tissues (normalized intensities)      RGS8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAAGACT
    RGS8 Expression
    About this image


    RGS8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5

    See RGS8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS8

    SOURCE GeneReport for Unigene clusters: Hs.20982 Hs.458417
        SABiosciences Custom PCR Arrays for RGS8
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGS8 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs81 , 5 regulator of G-protein signaling 81, 5 89.79(n)1
    97.69(a)1
      1 (65.41 cM)5
    677921  NM_026380.31  NP_080656.21 
     1536530255 
    chicken
    (Gallus gallus)
    Aves RGS81 regulator of G-protein signaling 8 82.27(n)
    90.17(a)
      426557  XM_424195.3  XP_424195.3 
    lizard
    (Anolis carolinensis)
    Reptilia RGS86
    --
    --
    85(a)
    24(a)
    1 ↔ 1
    possible ortholog
    GL343683.1(121615-157551)
    2(195533449-195593278)
    zebrafish
    (Danio rerio)
    Actinopterygii rgs81 regulator of G-protein signaling 8 65.65(n)
    64.63(a)
      436804  NM_001002531.1  NP_001002531.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-71 Protein RGS-7 51.18(n)
    48.82(a)
      180645  NM_001029544.2  NP_001024715.1 


    ENSEMBL Gene Tree for RGS8 (if available)
    TreeFam Gene Tree for RGS8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS8 gene
    RGS22  RGS192  RGS212  RGS32  RGS202  RGS162  RGS172  RGS52  
    RGS12  RGS182  RGS132  RGS42  
    18/20 SIMAP similar genes for RGS8 using alignment to 2 protein entries:     RGS8_HUMAN (see all proteins) (see all similar genes):
    RGS21    RGS1    RGS5    RGS3    RGS4    RGS16
    RGS13    RGS17    RGS2    RGS20    RGS18    RGS19
    RGS6    RGS7    RGS10    RGS14    AXIN1    RGS9

    RGS8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/642 SNPs in RGS8 are shown (see all 642)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925629901,2
    --182615300(+) AAACAA/GACAAC 2 -- ds50010--------
    rs1454945561,2
    C--182615374(+) TCCACA/GGAAAC 2 -- ds50010--------
    rs46527391,2
    C,F,A,H--182615444(+) GAGCCC/TAAGTC 2 -- ds500129Minor allele frequency- T:0.14NS EA NA CSA WA 3206
    rs1510613621,2
    --182615599(+) CAAGGA/CATTAT 2 -- ds50010--------
    rs1118661771,2
    C,F--182615691(+) GAATAG/CAGTCC 2 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1409639871,2
    --182615719(+) TCATAA/CTTTGG 2 -- ds50010--------
    rs1895669971,2
    --182615744(+) CCCTCC/TTCACC 2 -- ds50010--------
    rs1126476031,2
    C--182615748(+) CCTCA-/CCCCCA 2 -- ds50011Minor allele frequency- C:0.00CSA 2
    rs1923031371,2
    --182615756(+) CCAGCC/TTCCCA 2 -- ds50010--------
    rs1502209331,2
    --182615765(+) CACCCC/GCAATG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for RGS8 (182615239 - 182653711 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RGS8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3810CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS8
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607189    OMIM disorders: --

    7 diseases for RGS8:    About MalaCards
    q fever    ischemia    schizophrenia    squamous cell carcinoma
    prostate cancer    prostatitis    breast cancer


    RGS8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS8
    Human Genome Epidemiology (HuGE) Navigator: RGS8 (4 documents)

    Export disorders for RGS8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS8 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RGS8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3, 9 Sood R....Carpten J.D. (2001)
    2. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PubMed id 18262772)1, 4, 9 Campbell D.B....Sullivan P.F. (2008)
    3. Genetic variations in regulator of G-protein signalin g genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8. (PubMed id 18834863)1, 9 Fujii S....Saitoh O. (2008)
    8. Participation of RGS8 in the ternary complex of agonist, receptor and G-protein. (PubMed id 15506959)1, 9 Benians A....Tinker A. (2004)
    9. The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression. (PubMed id 14675160)1, 9 Masuho I....Saitoh O. (2004)
    10. Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics. (PubMed id 15677457)1, 9 Benians A....Tinker A. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85397 HGNC: 16810 AceView: RGS8 Ensembl:ENSG00000135824 euGenes: HUgn85397
    ECgene: RGS8 H-InvDB: RGS8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for RGS8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for RGS8 gene:
    Search GeneIP for patents involving RGS8

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