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Aliases for RGS8 Gene

Aliases for RGS8 Gene

  • Regulator Of G Protein Signaling 8 2 3
  • Regulator Of G-Protein Signaling 8 2 5
  • Regulator Of G-Protein Signalling 8 2

External Ids for RGS8 Gene

Previous GeneCards Identifiers for RGS8 Gene

  • GC01M180141
  • GC01M178044
  • GC01M179131
  • GC01M179855
  • GC01M179347
  • GC01M180877
  • GC01M153852

Summaries for RGS8 Gene

Entrez Gene Summary for RGS8 Gene

  • This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS8 Gene

RGS8 (Regulator Of G Protein Signaling 8) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS16.

UniProtKB/Swiss-Prot for RGS8 Gene

  • Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).

Gene Wiki entry for RGS8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS8 Gene

Genomics for RGS8 Gene

Regulatory Elements for RGS8 Gene

Enhancers for RGS8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G182632 1.4 Ensembl ENCODE dbSUPER 11.2 +120.6 120607 0.2 THRB ZNF2 RAD21 RARA ZNF335 RELB IKZF2 THAP11 ZNF362 HCFC1 RGS16 RGS8 GC01P182625 GC01M182641
GH01G182633 1.2 ENCODE dbSUPER 11.2 +119.3 119251 1.4 PKNOX1 SIN3A FEZF1 YBX1 ZNF2 FOS TSHZ1 ZNF488 REST SREBF1 RGS16 RGS8 GC01P182625 GC01M182641
GH01G182713 0.6 FANTOM5 11.4 +39.5 39477 0.1 MTA2 IKZF1 NR2F1 TBX21 IKZF2 RGS8 RGS16 DHX9 LINC01688 LOC100421471
GH01G182662 0.6 ENCODE 11 +90.6 90557 0.2 CTCF TEAD4 SMC3 ZNF580 KDM1A RAD21 RGS8 GC01M182641 LINC01688
GH01G182643 0.5 ENCODE 10.7 +109.4 109417 0.1 MNT ZBTB8A TRIM28 RGS16 RGS8 GC01M182641 LINC01688
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGS8 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS8 Gene

Chromosome:
1
Start:
182,641,816 bp from pter
End:
182,753,307 bp from pter
Size:
111,492 bases
Orientation:
Minus strand

Genomic View for RGS8 Gene

Genes around RGS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS8 Gene

Proteins for RGS8 Gene

  • Protein details for RGS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57771-RGS8_HUMAN
    Recommended name:
    Regulator of G-protein signaling 8
    Protein Accession:
    P57771
    Secondary Accessions:
    • B4DGL9
    • Q3SYD2

    Protein attributes for RGS8 Gene

    Size:
    180 amino acids
    Molecular mass:
    20917 Da
    Quaternary structure:
    • Interacts with GNAO1 (By similarity). Interacts with GNAI3.

    Three dimensional structures from OCA and Proteopedia for RGS8 Gene

    Alternative splice isoforms for RGS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS8 Gene

Post-translational modifications for RGS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS8 Gene

Domains & Families for RGS8 Gene

Gene Families for RGS8 Gene

Protein Domains for RGS8 Gene

Suggested Antigen Peptide Sequences for RGS8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS8: view

No data available for UniProtKB/Swiss-Prot for RGS8 Gene

Function for RGS8 Gene

Molecular function for RGS8 Gene

UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).

Gene Ontology (GO) - Molecular Function for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 18434541
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RGS8: view
genes like me logo Genes that share phenotypes with RGS8: view

Animal Models for RGS8 Gene

MGI Knock Outs for RGS8:

Animal Model Products

miRNA for RGS8 Gene

miRTarBase miRNAs that target RGS8

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RGS8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS8 Gene

Localization for RGS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS8 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, dendrite. Nucleus. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250 UniProtKB:P49804}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS8 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IEA,IBA --
GO:0016020 membrane IEA --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with RGS8: view

Pathways & Interactions for RGS8 Gene

genes like me logo Genes that share pathways with RGS8: view

Pathways by source for RGS8 Gene

Gene Ontology (GO) - Biological Process for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway ISS --
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IDA 18434541
GO:0060159 regulation of dopamine receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with RGS8: view

No data available for SIGNOR curated interactions for RGS8 Gene

Drugs & Compounds for RGS8 Gene

No Compound Related Data Available

Transcripts for RGS8 Gene

Unigene Clusters for RGS8 Gene

Regulator of G-protein signaling 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RGS8

Alternative Splicing Database (ASD) splice patterns (SP) for RGS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for RGS8 Gene

GeneLoc Exon Structure for
RGS8
ECgene alternative splicing isoforms for
RGS8

Expression for RGS8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS8 Gene

mRNA differential expression in normal tissues according to GTEx for RGS8 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.1), Brain - Caudate (basal ganglia) (x6.9), and Brain - Putamen (basal ganglia) (x6.6).

Protein differential expression in normal tissues from HIPED for RGS8 Gene

This gene is overexpressed in Monocytes (41.2), Retina (16.9), and Adipocyte (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS8 Gene



Protein tissue co-expression partners for RGS8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RGS8 Gene:

RGS8

SOURCE GeneReport for Unigene cluster for RGS8 Gene:

Hs.20982

Evidence on tissue expression from TISSUES for RGS8 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RGS8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS8 Gene

Orthologs for RGS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS8 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia RGS8 34 35
  • 93.77 (n)
cow
(Bos Taurus)
Mammalia RGS8 34 35
  • 93.06 (n)
rat
(Rattus norvegicus)
Mammalia Rgs8 34
  • 91.52 (n)
mouse
(Mus musculus)
Mammalia Rgs8 34 16 35
  • 89.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RGS8 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS8 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS8 34 35
  • 82.27 (n)
lizard
(Anolis carolinensis)
Reptilia RGS8 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs8 34
  • 64.01 (n)
zebrafish
(Danio rerio)
Actinopterygii rgs8 34 35
  • 67.08 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6075 34
Species where no ortholog for RGS8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS8 Gene

ENSEMBL:
Gene Tree for RGS8 (if available)
TreeFam:
Gene Tree for RGS8 (if available)

Paralogs for RGS8 Gene

Paralogs for RGS8 Gene

(20) SIMAP similar genes for RGS8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS8: view

Variants for RGS8 Gene

Sequence variations from dbSNP and Humsavar for RGS8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000029214 -- 182,710,376(+) AAGTC(A/T)GTCTC intron-variant
rs1000045687 -- 182,740,572(+) TTTTT(A/T)TATTG intron-variant
rs1000062751 -- 182,730,486(+) GGGCA(A/G)ATTGC intron-variant
rs1000082795 -- 182,653,088(+) AGCAC(C/T)ACAAA intron-variant
rs1000165561 -- 182,655,085(+) AGGTC(A/C)TGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS8 Gene

Variant ID Type Subtype PubMed ID
nsv3810 CNV deletion 18451855
nsv548358 CNV gain 21841781

Variation tolerance for RGS8 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS8 Gene

Disorders for RGS8 Gene

Relevant External Links for RGS8

Genetic Association Database (GAD)
RGS8
Human Genome Epidemiology (HuGE) Navigator
RGS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS8

No disorders were found for RGS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS8 Gene

Publications for RGS8 Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4 22 64
  2. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 22 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J. … Wu X. (Carcinogenesis 2010) 3 46 64
  5. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. (PMID: 18434541) Soundararajan M. … Siderovski D.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64

Products for RGS8 Gene

  • Addgene plasmids for RGS8

Sources for RGS8 Gene

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