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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS8 Gene

protein-coding   GIFtS: 52
GCID: GC01M182610

regulator of G-protein signaling 8

(Previous name: regulator of G-protein signalling 8 )
 Explore 8 diseases affiliated with
RGS8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGS8    

Aliases
for RGS8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of G-Protein Signaling 81 2
Regulator Of G-Protein Signalling 81 2
MGC1190671
MGC1190681
MGC1190691

External Ids:    HGNC: 168101   Entrez Gene: 853972   Ensembl: ENSG000001358247   OMIM: 6071895   UniProtKB: P577713   

Export aliases for RGS8 gene to outside databases

Previous GC identifers: GC01M180141 GC01M178044 GC01M179131 GC01M179855 GC01M179347 GC01M180877 GC01M153852


Summaries
for RGS8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RGS8:
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS
domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled
receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby
terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RGS8_HUMAN, P57771
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity)

Gene Wiki entry for RGS8


Genomic Views
for RGS8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS8 gene promoter:
         TBP   Lmo2   NF-AT   PPAR-gamma1   NF-AT4   NF-AT2   c-Myb   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS8 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

RGS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M182610:  view genomic region     (about GC identifiers)

Start:
 182,615,239 bp from pter      End:
 182,653,711 bp from pter
Size:
 38,473 bases      Orientation:
 minus strand

Proteins
for RGS8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RGS8_HUMAN, P57771 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 8  
Size: 180 amino acids; 20917 Da
2 PDB 3D structures from and Proteopedia for RGS8:
2IHD (3D)        2ODE (3D)    
Secondary accessions: B4DGL9 Q3SYD2
Alternative splicing: 2 isoforms:  P57771-1   P57771-2   

Explore the universe of human proteins at neXtProt for RGS8: NX_P57771

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P57771

    • RGS8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001095920.1  NP_203131.1  

    ENSEMBL proteins: 
     ENSP00000426289   ENSP00000258302   ENSP00000356528   ENSP00000356527   ENSP00000427076  

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    Novus Biologicals RGS8 Proteins
    Novus Biologicals RGS8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RGS8

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--


    RGS8 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RGS8

    Protein Domains /
    Families
    for RGS8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RGS8 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry P57771

    ProtoNet protein and cluster: P57771

    1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS8_HUMAN, P57771
    Similarity: Contains 1 RGS domain


    Function
    for RGS8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RGS8_HUMAN, P57771
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
    them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity)

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: RGS8
    OriGene siRNA: RGS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS8

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for RGS8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS8

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--


    RGS8 for ontologies           About GeneDecksing



    Pathways & Interactions
    for RGS8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-AlphaQ Signaling
    		G-AlphaQ Signaling1.00
    		G-AlphaI Signaling0.47
    2Activation of cAMP-Dependent PKA
    		cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS8
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGS8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RGS8 (ENSP000002583024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI3ENSP000003588674STRING: ENSP00000358867
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity IBA--


    RGS8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGS8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS8
    Search CenterWatch for drugs/clinical trials and news about RGS8 

    Transcripts
    for RGS8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGS8 gene (2 alternative transcripts): 
    NM_001102450.1  NM_033345.2  

    Unigene Clusters for RGS8:

    Regulator of G-protein signaling 8
    Hs.20982  [show with all ESTs], Hs.458417  [show with all ESTs]
    Unigene Representative Sequences: AK057753, AK294660
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483095(uc010pnw.1) ENST00000258302(uc001gpm.1) ENST00000367557(uc001gpn.1)
    ENST00000367556 ENST00000491420 ENST00000508450 ENST00000515211

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS8 (see all 7)
    OriGene shRNA RFP: RGS8
    OriGene siRNA: RGS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS8
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS8 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS8

    Additional cDNA sequence: 

    AF297015.1 AF300649.1 AK294660.1 AK296514.1 BC069677.1 BC069718.1 BC103865.1 BC103866.1 
    BC103867.1 

    4 DOTS entries:

    DT.95330573  DT.211223  DT.95311259  DT.95263015 

    24/29 AceView cDNA sequences (see all 29):

    AF300649 BM725999 AF297015 BX954018 BU733370 BM709429 NM_033345 AF297014 
    AH010175 BC069718 Z39283 H17666 CB565900 BC069677 BX108838 BM681011 
    Z43204 AI209102 BG195915 BX281622 R55736 R37101 BI002651 AK057753 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RGS8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:              -                                 


    ECgene alternative splicing isoforms for RGS8

    Expression
    for RGS8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAAAGACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RGS8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation and expan...)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See RGS8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS8

    SOURCE GeneReport for Unigene clusters: Hs.20982 Hs.458417
        SABiosciences Custom PCR Arrays for RGS8
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    In Situ
    Assay Products:     
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    Orthologs
    for RGS8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RGS8 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RGS81 regulator of G-protein signaling 8 82.27(n)
    90.17(a)    		   426557  XM_424195.3  XP_424195.3 
    lizard
    (Anolis carolinensis)    		 Reptilia RGS86
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL343683.1(121615-140315)
    zebrafish
    (Danio rerio)    		 Actinopterygii rgs81 regulator of G-protein signaling 8 65.65(n)
    64.63(a)    		   436804  NM_001002531.1  NP_001002531.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rgs-71 Protein RGS-7 51.18(n)
    48.82(a)    		   180645  NM_001029544.2  NP_001024715.1 


    ENSEMBL Gene Tree for RGS8 (if available)
    TreeFam Gene Tree for RGS8 (if available) 

    Paralogs
    for RGS8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS8 gene
    RGS22  RGS192  RGS212  RGS32  RGS162  RGS202  RGS52  RGS172  
    RGS12  RGS182  RGS42  RGS132  
    18/20 SIMAP similar genes for RGS8 using alignment to 2 protein entries:     RGS8_HUMAN (see all proteins) (see all similar genes):
    RGS21    RGS1    RGS5    RGS4    RGS3    RGS16
    RGS13    RGS17    RGS2    RGS20    RGS18    RGS19
    RGS6    RGS7    RGS10    RGS14    AXIN1    RGS9

    RGS8 for paralogs           About GeneDecksing



    Genomic Variants
    for RGS8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/529 NCBI SNPs in RGS8 are shown (see all 529)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1925629901,2
    		--182615300(+) AAACAA/GACAAC 2 -- ds50010--------
    rs1454945561,2
    		--182615374(+) TCCACA/GGAAAC 2 -- ds50010--------
    rs46527391,2
    		C,F,A,H,--182615444(+) GAGCCC/TAAGTC 2 -- ds500129Minor allele frequency- T:0.14NS EA NA CSA WA 3206
    rs1510613621,2
    		--182615599(+) CAAGGA/CATTAT 2 -- ds50010--------
    rs1118661771,2
    		--182615691(+) GAATAG/CAGTCC 2 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1409639871,2
    		--182615719(+) TCATAA/CTTTGG 2 -- ds50010--------
    rs1895669971,2
    		--182615744(+) CCCTCC/TTCACC 2 -- ds50010--------
    rs1126476031,2
    		C,--182615748(+) CCTCA-/CCCCCA 2 -- ds50011Minor allele frequency- C:0.00CSA 2
    rs1923031371,2
    		--182615756(+) CCAGCC/TTCCCA 2 -- ds50010--------
    rs1502209331,2
    		--182615765(+) CACCCC/GCAATG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for RGS8 (182615239 - 182653711 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RGS8: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS8
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS8

    Disorders / Diseases
    for RGS8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGS8 for disorders           About GeneDecksing

    OMIM gene information: 607189    OMIM disorders: --

    8 diseases for RGS8:    About MalaCards
    q fever    squamous cell carcinoma    prostate cancer    breast cancer
    ischemia    prostatitis    schizophrenia    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: RGS8 (4 documents)

    Export disorders for RGS8 gene to outside databases

    Publications
    for RGS8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS8 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RGS8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3, 9 Sood R....Carpten J.D. (2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8. (PubMed id 18834863)1, 9 Fujii S....Saitoh O. (2008)
    5. Participation of RGS8 in the ternary complex of agonist, receptor and G-protein. (PubMed id 15506959)1, 9 Benians A....Tinker A. (2004)
    6. The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression. (PubMed id 14675160)1, 9 Masuho I....Saitoh O. (2004)
    7. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PubMed id 18262772)1, 9 Campbell D.B....Sullivan P.F. (2008)
    8. Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics. (PubMed id 15677457)1, 9 Benians A....Tinker A. (2005)
    9. Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. (PubMed id 14992813)1, 9 Larminie C....Garnier M. (2004)
    10. High-resolution melting analysis for mutation screeni ng of RGSL1, RGS16, and RGS8 in breast cancer. (PubMed id 21135262)1 Wiechec E....Hansen L.L. (2011)

    External Searches for RGS8 gene

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    Genome Databases showing RGS8 gene

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    Entrez Gene: 85397 HGNC: 16810 AceView: RGS8 Ensembl:ENSG00000135824 euGenes: HUgn85397
    ECgene: RGS8 H-InvDB: RGS8

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