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Aliases for RGS8 Gene

Aliases for RGS8 Gene

  • Regulator Of G-Protein Signaling 8 2 3
  • Regulator Of G-Protein Signalling 8 2

External Ids for RGS8 Gene

Previous GeneCards Identifiers for RGS8 Gene

  • GC01M180141
  • GC01M178044
  • GC01M179131
  • GC01M179855
  • GC01M179347
  • GC01M180877
  • GC01M153852

Summaries for RGS8 Gene

Entrez Gene Summary for RGS8 Gene

  • This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS8 Gene

RGS8 (Regulator Of G-Protein Signaling 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS8 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).

Gene Wiki entry for RGS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS8 Gene

Genomics for RGS8 Gene

Regulatory Elements for RGS8 Gene

Genomic Location for RGS8 Gene

Start:
182,643,901 bp from pter
End:
182,684,576 bp from pter
Size:
40,676 bases
Orientation:
Minus strand

Genomic View for RGS8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS8 Gene

Proteins for RGS8 Gene

  • Protein details for RGS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57771-RGS8_HUMAN
    Recommended name:
    Regulator of G-protein signaling 8
    Protein Accession:
    P57771
    Secondary Accessions:
    • B4DGL9
    • Q3SYD2

    Protein attributes for RGS8 Gene

    Size:
    180 amino acids
    Molecular mass:
    20917 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS8 Gene

    Alternative splice isoforms for RGS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS8 Gene

Proteomics data for RGS8 Gene at MOPED

Post-translational modifications for RGS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS8 Gene

No data available for DME Specific Peptides for RGS8 Gene

Domains for RGS8 Gene

Gene Families for RGS8 Gene

HGNC:
  • RGS :Regulators of G-protein signaling

Protein Domains for RGS8 Gene

Suggested Antigen Peptide Sequences for RGS8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57771

UniProtKB/Swiss-Prot:

RGS8_HUMAN :
  • P57771
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS8: view

Function for RGS8 Gene

Molecular function for RGS8 Gene

UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).

Gene Ontology (GO) - Molecular Function for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RGS8: view

Animal Model Products

CRISPR Products

miRNA for RGS8 Gene

miRTarBase miRNAs that target RGS8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGS8 Gene

Localization for RGS8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS8 Gene COMPARTMENTS Subcellular localization image for RGS8 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGS8 Gene

Pathways for RGS8 Gene

genes like me logo Genes that share pathways with RGS8: view

Pathways by source for RGS8 Gene

Gene Ontology (GO) - Biological Process for RGS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RGS8: view

Transcripts for RGS8 Gene

Unigene Clusters for RGS8 Gene

Regulator of G-protein signaling 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for RGS8 Gene

GeneLoc Exon Structure for
RGS8
ECgene alternative splicing isoforms for
RGS8

Expression for RGS8 Gene

mRNA expression in normal human tissues for RGS8 Gene

mRNA differential expression in normal tissues according to GTEx for RGS8 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (14.1), Brain - Caudate (basal ganglia) (6.9), and Brain - Putamen (basal ganglia) (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGS8 Gene

SOURCE GeneReport for Unigene cluster for RGS8 Gene Hs.20982

genes like me logo Genes that share expressions with RGS8: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RGS8 Gene

Orthologs for RGS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS8 35
  • 99.49 (n)
  • 99.49 (a)
RGS8 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS8 35
  • 93.06 (n)
  • 98.84 (a)
RGS8 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS8 35
  • 93.77 (n)
  • 97.98 (a)
RGS8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs8 35
  • 89.79 (n)
  • 97.69 (a)
Rgs8 16
Rgs8 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS8 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS8 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs8 35
  • 91.52 (n)
  • 98.27 (a)
chicken
(Gallus gallus)
Aves RGS8 35
  • 82.27 (n)
  • 90.17 (a)
RGS8 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS8 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs8 35
  • 64.01 (n)
  • 63.3 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6075 35
zebrafish
(Danio rerio)
Actinopterygii rgs8 35
  • 67.08 (n)
  • 66.26 (a)
rgs8 36
  • 61 (a)
OneToOne
Species with no ortholog for RGS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS8 Gene

ENSEMBL:
Gene Tree for RGS8 (if available)
TreeFam:
Gene Tree for RGS8 (if available)

Paralogs for RGS8 Gene

Paralogs for RGS8 Gene

Selected SIMAP similar genes for RGS8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS8: view

Variants for RGS8 Gene

Sequence variations from dbSNP and Humsavar for RGS8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs482490 -- 182,671,948(+) CGGGC(A/G)GCGGC intron-variant, upstream-variant-2KB
rs491587 -- 182,648,926(+) CAAAA(C/T)GTCAT intron-variant
rs493541 -- 182,666,556(+) CAGTT(A/G)TTTCC intron-variant
rs508709 -- 182,663,100(+) TCTTT(A/G)CTTCT intron-variant
rs512189 -- 182,663,452(+) CTCCA(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS8 Gene

Variant ID Type Subtype PubMed ID
nsv3810 CNV Loss 18451855

Relevant External Links for RGS8 Gene

HapMap Linkage Disequilibrium report
RGS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS8 Gene

Disorders for RGS8 Gene

Relevant External Links for RGS8

Genetic Association Database (GAD)
RGS8
Human Genome Epidemiology (HuGE) Navigator
RGS8
genes like me logo Genes that share disorders with RGS8: view

No data available for UniProtKB/Swiss-Prot for RGS8 Gene

Publications for RGS8 Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4 23
  2. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 23 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for RGS8 Gene

  • Addgene plasmids for RGS8

Sources for RGS8 Gene

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