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RGS7BP Gene

protein-coding   GIFtS: 49
GCID: GC05P063802

Regulator Of G-Protein Signaling 7 Binding Protein

(Previous name: regulator of G-protein signalling 7 binding protein)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Regulator Of G-Protein Signaling 7 Binding Protein1 2
R7BP2 3 5
R7 Family-Binding Protein2 3
Regulator Of G-Protein Signalling 7 Binding Protein1
Regulator Of G-Protein Signaling 7-Binding Protein2

External Ids:    HGNC: 232711   Entrez Gene: 4011902   Ensembl: ENSG000001864797   OMIM: 6108905   UniProtKB: Q6MZT13   
ORGUL members:         

Export aliases for RGS7BP gene to outside databases

Previous GC identifers: GC05P063840 GC05P060756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS7BP Gene:
This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and
regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated
by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to
the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided
by RefSeq, Dec 2012)

GeneCards Summary for RGS7BP Gene:
RGS7BP (regulator of G-protein signaling 7 binding protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: R7BP_HUMAN, Q6MZT1
Function: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes
that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the
R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is
unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the
proteolytic stability of R7 proteins, probably by protecting them from degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS7BP gene promoter:
         HOXA9   E2F-3a   E2F-4   E2F-5   Nkx2-2   E2F-2   Nkx6-1   E2F   E2F-1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS7BP promoter sequence
   Search Chromatin IP Primers for RGS7BP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS7BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

RGS7BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS7BP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P063802:  view genomic region     (about GC identifiers)

Start:
63,802,084 bp from pter      End:
63,908,139 bp from pter
Size:
106,056 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: R7BP_HUMAN, Q6MZT1 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 7-binding protein  
Size: 257 amino acids; 28962 Da
Subunit: Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and RGS11. Component of some R7-Gbeta5 complex
composed of some R7 protein (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP (By similarity)

Explore the universe of human proteins at neXtProt for RGS7BP: NX_Q6MZT1

Explore proteomics data for RGS7BP at MOPED

Post-translational modifications: 

  • Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon
    depalmitoylation, it is targeted into the nucleus (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS7BP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001025046.1  NP_001258819.1  NP_001258820.1  

    ENSEMBL proteins: 
     ENSP00000334851  

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    antibodies-online kits for RGS7BP (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026512 RGS7BP/RGS9BP

    Graphical View of Domain Structure for InterPro Entry Q6MZT1

    ProtoNet protein and cluster: Q6MZT1

    UniProtKB/Swiss-Prot: R7BP_HUMAN, Q6MZT1
    Domain: The nuclear localization signal is both required for nuclear localization and palmitoylation (By
    similarity)
    Similarity: Belongs to the RGS7BP/RGS9BP family


    Find genes that share domains with RGS7BP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: R7BP_HUMAN, Q6MZT1
    Function: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes
    that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the
    R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is
    unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the
    proteolytic stability of R7 proteins, probably by protecting them from degradation (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RGS7BP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RGS7BP:
     Big cells 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgs7bp):
     behavior/neurological  nervous system  normal 

    Find genes that share phenotypes with RGS7BP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgs7bptm1Itl for RGS7BP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS7BP
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    SwitchGear 3'UTR luciferase reporter plasmidRGS7BP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    R7BP_HUMAN, Q6MZT1: Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane; Lipid-anchor (By
    similarity). Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by
    palmitoylation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with RGS7BP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS7BP
    Interactions:

        Search GeneGlobe Interaction Network for RGS7BP

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0009968negative regulation of signal transduction IEA--

    Find genes that share ontologies with RGS7BP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS7BP (R7BP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGS7BP gene (3 alternative transcripts): 
    NM_001029875.2  NM_001271890.1  NM_001271891.1  

    Unigene Cluster for RGS7BP:

    Regulator of G-protein signaling 7 binding protein
    Hs.657133  [show with all ESTs]
    Unigene Representative Sequence: NM_001029875
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508162 ENST00000334025(uc003jtj.3 uc011cqu.2) ENST00000505263

    miRNA
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    hsa-miR-3678-3p hsa-miR-548j hsa-miR-200a hsa-miR-374a hsa-miR-4275 hsa-miR-1304 hsa-miR-376a* hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidRGS7BP 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat RGS7BP
      QuantiFast Probe-based Assays in human, mouse, rat RGS7BP

    Additional mRNA sequence: 

    AK294808.1 AK296443.1 AK296494.1 BC140707.1 BX640900.1 NR_073511.1 

    3 DOTS entries:

    DT.112298  DT.120860974  DT.120860975 

    4 AceView cDNA sequences:

    AL700423 BX953830 BX953831 BX492447 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS7BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTTGTGG
    RGS7BP Expression
    About this image

    RGS7BP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS7BP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657133
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RGS7BP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs7bp1 , 5 regulator of G-protein signalling 7 binding protein1, 5 91.83(n)1
    94.55(a)1
      13 (56.90 cM)5
    528821  NM_029879.21  NP_084155.21 
     1049471535 
    chicken
    (Gallus gallus)
    Aves RGS7BP1 regulator of G-protein signaling 7 binding protein 79.74(n)
    83.14(a)
      770874  XM_001234191.3  XP_001234192.2 
    lizard
    (Anolis carolinensis)
    Reptilia RGS7BP6
    regulator of G-protein signaling 7 binding protein...
    84(a)
    1 ↔ 1
    1(226347749-226424903)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rgs7bp1 regulator of G-protein signaling 7 binding protein 78.92(n)
    81.03(a)
      100488664  XM_002934197.2  XP_002934243.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgs7bpa1 regulator of G-protein signaling 7 binding protein more 72.74(n)
    75.71(a)
      767669  NM_001076608.1  NP_001070076.1 


    ENSEMBL Gene Tree for RGS7BP (if available)
    TreeFam Gene Tree for RGS7BP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS7BP gene
    1 SIMAP similar gene for RGS7BP using alignment to 1 protein entry:     R7BP_HUMAN:
    R7BP

    Find genes that share paralogs with RGS7BP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS7BP (see all 1971)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674265461,2
    C--60810538(-) TAGAT-/TATATAT 1 -- int12Minor allele frequency- TA:0.00NA CSA 4
    rs2726451,2
    C,F,A--63799778(+) ggcgcG/Agtggc 1 -- us2k111Minor allele frequency- A:0.22WA NA CSA EA 372
    rs1461220351,2
    --63799862(+) CTGGGA/CAACAT 1 -- us2k10--------
    rs1401442921,2
    --63799938(+) TGAAGC/TGGGAG 1 -- us2k10--------
    rs1141012021,2
    F--63799987(+) CTCATG/AGTGTC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1498475881,2
    --63800165(+) GCCTAA/CAACTC 1 -- us2k10--------
    rs769687241,2
    C--63800225(+) GGCTCA/CGTCCC 1 -- us2k10--------
    rs1483955851,2
    --63800306(+) CTTGGC/TGACAA 1 -- us2k10--------
    rs1159469851,2
    F--63800307(+) TTGGCG/AACAAA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1388880571,2
    C--63800504(+) GGTGT-/ACCACCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGS7BP (63802084 - 63908139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RGS7BP (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663116CNV Deletion23128226
    esv2667008CNV Deletion23128226
    esv2670220CNV Deletion23128226
    esv272469CNV Insertion20981092
    esv268374CNV Insertion20981092
    nsv4861CNV Loss18451855
    nsv508364CNV Loss20534489
    nsv830324CNV Loss17160897
    dgv6082n71CNV Loss21882294
    nsv881748CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS7BP
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610890    OMIM disorders: --


    Find genes that share disorders with RGS7BP           About GenesLikeMe

    Genetic Association Database (GAD): RGS7BP
    Human Genome Epidemiology (HuGE) Navigator: RGS7BP (1 document)

    Export disorders for RGS7BP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS7BP gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with RGS7BP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. (PubMed id 15632198)1, 3 Martemyanov K.A....Arshavsky V.Y. (J. Biol. Chem. 2005)
    3. Association analysis of RGS7BP gene polymorphisms with aspirin intolerance in asthmatic patients. (PubMed id 21457877)1 Lee E.H....Park C.S. (amp 2011)
    4. Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors. (PubMed id 21511947)1 Masuho I....Martemyanov K.A. (J. Biol. Chem. 2011)
    5. R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling. (PubMed id 19042037)1 Jayaraman M....Blumer K.J. (Trends Pharmacol. Sci. 2009)
    6. RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11. (PubMed id 19497306)1 Saleem Y. and Kim K.S. (Biochem. Biophys. Res. Commun. 2009)
    7. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism. (PubMed id 16867977)1 Drenan R.M....Blumer K.J. (J. Biol. Chem. 2006)
    10. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 401190 HGNC: 23271 AceView: DKFZp686I0554.1 Ensembl:ENSG00000186479 euGenes: HUgn401190
    ECgene: RGS7BP H-InvDB: RGS7BP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGS7BP Pharmacogenomics, SNPs, Pathways

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