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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS7BP Gene

protein-coding   GIFtS: 46
GCID: GC05P063802

regulator of G-protein signaling 7 binding protein

(Previous name: regulator of G-protein signalling 7 binding protein )
 Explore 1 disease affiliated with
RGS7BP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGS7BP    

Aliases
for RGS7BP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of G-Protein Signaling 7 Binding Protein1 2
R7BP1 2 3 5
R7 Family-Binding Protein2 3
Regulator Of G-Protein Signalling 7 Binding Protein1
Regulator Of G-Protein Signaling 7-Binding Protein2

External Ids:    HGNC: 232711   Entrez Gene: 4011902   Ensembl: ENSG000001864797   OMIM: 6108905   UniProtKB: Q6MZT13   

Export aliases for RGS7BP gene to outside databases

Previous GC identifers: GC05P063840 GC05P060756


Summaries
for RGS7BP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RGS7BP:
This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and
regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by
reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the
nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by
RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: R7BP_HUMAN, Q6MZT1
Function: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that
acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5
complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the
R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of
R7 proteins, probably by protecting them from degradation (By similarity)




Genomic Views
for RGS7BP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS7BP gene promoter:
         HOXA9   E2F-3a   E2F-4   E2F-5   Nkx2-2   E2F-2   Nkx6-1   E2F   E2F-1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS7BP promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS7BP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS7BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

RGS7BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS7BP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P063802:  view genomic region     (about GC identifiers)

Start:
 63,802,084 bp from pter      End:
 63,908,139 bp from pter
Size:
 106,056 bases      Orientation:
 plus strand

Proteins
for RGS7BP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: R7BP_HUMAN, Q6MZT1 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 7-binding protein  
Size: 257 amino acids; 28962 Da
Subunit: Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and RGS11. Component of some R7-Gbeta5 complex composed
of some R7 protein (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane; Lipid-anchor (By similarity).
Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation (By
similarity)

Explore the universe of human proteins at neXtProt for RGS7BP: NX_Q6MZT1

Post-translational modifications:

  • Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon
    • depalmitoylation, it is targeted into the nucleus (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6MZT1

    • RGS7BP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001025046.1  NP_001258819.1  NP_001258820.1  

    ENSEMBL proteins: 
     ENSP00000334851  

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    Uscn Proteins for RGS7BP

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--


    RGS7BP for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RGS7BP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RGS7BP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026512 RGS7BP/RGS9BP

    Graphical View of Domain Structure for InterPro Entry Q6MZT1

    ProtoNet protein and cluster: Q6MZT1

    UniProtKB/Swiss-Prot: R7BP_HUMAN, Q6MZT1
    Domain: The nuclear localization signal is both required for nuclear localization and palmitoylation (By similarity)
    Similarity: Belongs to the RGS7BP/RGS9BP family


    Function
    for RGS7BP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: R7BP_HUMAN, Q6MZT1
    Function: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that
    acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5
    complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the
    R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of
    R7 proteins, probably by protecting them from degradation (By similarity)

    miRNA
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    hsa-miR-3678-3p hsa-miR-548j hsa-miR-200a hsa-miR-374a hsa-miR-4275 hsa-miR-1304 hsa-miR-376a* hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmid: RGS7BP 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    RGS7BP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RGS7BP:
     Big cells 

    Animal Models:
         Mouse knock-out Rgs7bptm1Itl for RGS7BP
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rgs7bp):
     behavior/neurological  nervous system  normal 

    RGS7BP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RGS7BP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGS7BP

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0009968negative regulation of signal transduction IEA--


    RGS7BP for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGS7BP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS7BP
    Search CenterWatch for drugs/clinical trials and news about RGS7BP / R7BP 

    Transcripts
    for RGS7BP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGS7BP gene (3 alternative transcripts): 
    NM_001029875.2  NM_001271890.1  NM_001271891.1  

    Unigene Cluster for RGS7BP:

    Regulator of G-protein signaling 7 binding protein
    Hs.657133  [show with all ESTs]
    Unigene Representative Sequence: NM_001029875
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508162 ENST00000334025(uc003jtj.3 uc011cqu.2) ENST00000505263


    miRNA
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    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS7BP (see all 84):
    hsa-miR-3678-3p hsa-miR-548j hsa-miR-200a hsa-miR-374a hsa-miR-4275 hsa-miR-1304 hsa-miR-376a* hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmid: RGS7BP 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS7BP
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    Additional cDNA sequence: 

    AK294808.1 AK296443.1 AK296494.1 BC140707.1 BX640900.1 NR_073511.1 

    3 DOTS entries:

    DT.112298  DT.120860974  DT.120860975 

    4 AceView cDNA sequences:

    BX953830 BX953831 AL700423 BX492447 

    GeneLoc Exon Structure


    Expression
    for RGS7BP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS7BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTTTGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RGS7BP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMaxillary ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RGS7BP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS7BP

    SOURCE GeneReport for Unigene cluster: Hs.657133
        SABiosciences Custom PCR Arrays for RGS7BP
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    In Situ
    Assay Products:     
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    Orthologs
    for RGS7BP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RGS7BP gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rgs7bp1 , 5 regulator of G-protein signalling 7 binding protein1, 5 91.83(n)1
    94.55(a)1    		   13 (56.90 cM)5
    528821  NM_029879.21  NP_084155.21 
     1049471535 
    chicken
    (Gallus gallus)    		 Aves RGS7BP1 regulator of G-protein signaling 7 binding protein 79.74(n)
    83.14(a)    		   770874  XM_001234191.2  XP_001234192.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RGS7BP6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 1(226348501-226423972)
    zebrafish
    (Danio rerio)    		 Actinopterygii rgs7bpa1 regulator of G-protein signaling 7 binding protein more 72.74(n)
    75.71(a)    		   767669  NM_001076608.1  NP_001070076.1 


    ENSEMBL Gene Tree for RGS7BP (if available)
    TreeFam Gene Tree for RGS7BP (if available) 

    Paralogs
    for RGS7BP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RGS7BP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1701 NCBI SNPs in RGS7BP are shown (see all 1701)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs347452751,2
    		C,--60827107(+) GATTT-/AAAAAT 1 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs1388880571,2
    		C,--63800504(+) GGTGT-/ACCACCCT 1 -- us2k10--------
    rs1425132571,2
    		--63800571(+) TTAGGA/TGTTTT 1 -- us2k10--------
    rs68835171,2
    		C,H,--63800747(+) AACTCA/GGGCAA 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs21363001,2
    		C,H--63800756(+) AATTTC/TTAAGG 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1906466751,2
    		--63800853(+) GAAAAG/TGTTGT 1 -- us2k10--------
    rs1832169261,2
    		--63800891(+) TTCCTC/GGCTAT 1 -- us2k10--------
    rs1888854991,2
    		--63801189(+) ATCCCC/TGATTT 1 -- us2k10--------
    rs1475786331,2
    		--63801230(+) CTGATA/GTCCCA 1 -- us2k10--------
    rs1420567071,2
    		--63801327(+) GAGTCC/TTGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGS7BP (63802084 - 63908139 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RGS7BP
         1 Inversion: 37262

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS7BP
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS7BP

    Disorders / Diseases
    for RGS7BP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGS7BP for disorders           About GeneDecksing

    OMIM gene information: 610890    OMIM disorders: --

    1 disease for RGS7BP:    About MalaCards
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: RGS7BP (1 document)

    Export disorders for RGS7BP gene to outside databases

    Publications
    for RGS7BP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS7BP gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with RGS7BP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. (PubMed id 15632198)1, 3 Martemyanov K.A....Arshavsky V.Y. (2005)
    2. Type 5 G protein beta subunit (Gbeta5) controls the i nteraction of regulator of G protein signaling 9 (RGS9) with membrane anchors. (PubMed id 21511947)1 Masuho I....Martemyanov K.A. (2011)
    3. Association analysis of RGS7BP gene polymorphisms wit h aspirin intolerance in asthmatic patients. (PubMed id 21457877)1 Lee E.H....Park C.S. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. RGS11 interacts preferentially with R7BP over Galpha( oa)--characterization of Gbeta5-free RGS11. (PubMed id 19497306)1 Saleem Y. and Kim K.S. (2009)
    6. R9AP and R7BP: traffic cops for the RGS7 family in pho totransduction and neuronal GPCR signaling. (PubMed id 19042037)1 Jayaraman M....Blumer K.J. (2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism. (PubMed id 16867977)1 Drenan R.M....Blumer K.J. (2006)
    9. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for RGS7BP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing RGS7BP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 401190 HGNC: 23271 AceView: DKFZp686I0554.1 Ensembl:ENSG00000186479 euGenes: HUgn401190
    ECgene: RGS7BP H-InvDB: RGS7BP

    Other Databases showing RGS7BP gene

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    Specialized Databases showing RGS7BP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    PharmGKB entry for RGS7BP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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