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Aliases for RGS7BP Gene

Aliases for RGS7BP Gene

  • Regulator Of G-Protein Signaling 7 Binding Protein 2 3
  • R7BP 3 4 6
  • R7 Family-Binding Protein 3 4
  • Regulator Of G-Protein Signalling 7 Binding Protein 2
  • Regulator Of G-Protein Signaling 7-Binding Protein 3

External Ids for RGS7BP Gene

Previous GeneCards Identifiers for RGS7BP Gene

  • GC05P063840
  • GC05P063802
  • GC05P060756

Summaries for RGS7BP Gene

Entrez Gene Summary for RGS7BP Gene

  • This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for RGS7BP Gene

RGS7BP (Regulator Of G-Protein Signaling 7 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RGS7BP Gene

  • Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS7BP Gene

Genomics for RGS7BP Gene

Regulatory Elements for RGS7BP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGS7BP Gene

Start:
64,505,947 bp from pter
End:
64,612,312 bp from pter
Size:
106,366 bases
Orientation:
Plus strand

Genomic View for RGS7BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS7BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS7BP Gene

Proteins for RGS7BP Gene

  • Protein details for RGS7BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6MZT1-R7BP_HUMAN
    Recommended name:
    Regulator of G-protein signaling 7-binding protein
    Protein Accession:
    Q6MZT1
    Secondary Accessions:
    • B7Z3X1

    Protein attributes for RGS7BP Gene

    Size:
    257 amino acids
    Molecular mass:
    28962 Da
    Quaternary structure:
    • Interacts with R7 family proteins RGS6, RGS7, RGS9 and RGS11. Component of some R7-Gbeta5 complex composed of some R7 protein (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP (By similarity).

neXtProt entry for RGS7BP Gene

Proteomics data for RGS7BP Gene at MOPED

Post-translational modifications for RGS7BP Gene

  • Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon depalmitoylation, it is targeted into the nucleus (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS7BP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS7BP Gene

Domains for RGS7BP Gene

Protein Domains for RGS7BP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGS7BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6MZT1

UniProtKB/Swiss-Prot:

R7BP_HUMAN :
  • Q6MZT1
Domain:
  • The nuclear localization signal is both required for nuclear localization and palmitoylation.
Family:
  • Belongs to the RGS7BP/RGS9BP family.
genes like me logo Genes that share domains with RGS7BP: view

No data available for Gene Families for RGS7BP Gene

Function for RGS7BP Gene

Molecular function for RGS7BP Gene

UniProtKB/Swiss-Prot Function: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation (By similarity).

Gene Ontology (GO) - Molecular Function for RGS7BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGS7BP: view

Phenotypes for RGS7BP Gene

MGI mutant phenotypes for RGS7BP:
inferred from 1 alleles
GenomeRNAi human phenotypes for RGS7BP:
genes like me logo Genes that share phenotypes with RGS7BP: view

Animal Models for RGS7BP Gene

MGI Knock Outs for RGS7BP:

Animal Model Products

CRISPR Products

miRNA for RGS7BP Gene

miRTarBase miRNAs that target RGS7BP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS7BP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RGS7BP Gene

Localization for RGS7BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS7BP Gene

Nucleus. Cytoplasm. Cell membrane; Lipid-anchor. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS7BP Gene COMPARTMENTS Subcellular localization image for RGS7BP gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RGS7BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RGS7BP: view

Pathways for RGS7BP Gene

SuperPathways for RGS7BP Gene

No Data Available

Interacting Proteins for RGS7BP Gene

Gene Ontology (GO) - Biological Process for RGS7BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0009968 negative regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with RGS7BP: view

No data available for Pathways by source for RGS7BP Gene

Transcripts for RGS7BP Gene

mRNA/cDNA for RGS7BP Gene

(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGS7BP Gene

Regulator of G-protein signaling 7 binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS7BP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RGS7BP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS7BP Gene

No ASD Table

Relevant External Links for RGS7BP Gene

GeneLoc Exon Structure for
RGS7BP
ECgene alternative splicing isoforms for
RGS7BP

Expression for RGS7BP Gene

mRNA expression in normal human tissues for RGS7BP Gene

mRNA differential expression in normal tissues according to GTEx for RGS7BP Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.6), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Putamen (basal ganglia) (4.3), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGS7BP Gene

SOURCE GeneReport for Unigene cluster for RGS7BP Gene Hs.657133

genes like me logo Genes that share expressions with RGS7BP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RGS7BP Gene

Orthologs for RGS7BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS7BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS7BP 35
  • 99.87 (n)
  • 99.61 (a)
RGS7BP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS7BP 35
  • 93.51 (n)
  • 96.89 (a)
RGS7BP 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS7BP 35
  • 95.59 (n)
  • 98.44 (a)
RGS7BP 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs7bp 35
  • 91.83 (n)
  • 94.55 (a)
Rgs7bp 16
Rgs7bp 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS7BP 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS7BP 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs7bp 35
  • 91.18 (n)
  • 95.72 (a)
chicken
(Gallus gallus)
Aves RGS7BP 35
  • 79.74 (n)
  • 83.14 (a)
RGS7BP 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS7BP 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs7bp 35
  • 78.92 (n)
  • 81.03 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs7bpa 35
  • 72.74 (n)
  • 75.71 (a)
rgs7bpa 36
  • 75 (a)
OneToMany
rgs7bpb 36
  • 71 (a)
OneToMany
Species with no ortholog for RGS7BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS7BP Gene

ENSEMBL:
Gene Tree for RGS7BP (if available)
TreeFam:
Gene Tree for RGS7BP (if available)

Paralogs for RGS7BP Gene

Selected SIMAP similar genes for RGS7BP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS7BP: view

No data available for Paralogs for RGS7BP Gene

Variants for RGS7BP Gene

Sequence variations from dbSNP and Humsavar for RGS7BP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs876 -- 64,612,173(-) TGGTG(-/G)AATTC utr-variant-3-prime, nc-transcript-variant
rs166632 -- 64,556,876(-) CTTCT(A/C)TCAGC intron-variant
rs172061 -- 64,514,187(-) TGACT(A/G)CTGTC intron-variant
rs172062 -- 64,516,305(-) GGGTG(G/T)GGGCA intron-variant
rs175371 -- 64,518,045(-) TCCCC(A/G)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS7BP Gene

Variant ID Type Subtype PubMed ID
nsv830323 CNV Gain 17160897
nsv7370 OTHER Inversion 18451855
nsv830324 CNV Loss 17160897
nsv4861 CNV Loss 18451855
dgv6082n71 CNV Loss 21882294
dgv6083n71 CNV Gain 21882294
nsv881748 CNV Gain 21882294
esv2667008 CNV Deletion 23128226
esv268374 CNV Insertion 20981092
esv272469 CNV Insertion 20981092
esv2670220 CNV Deletion 23128226
esv2663116 CNV Deletion 23128226
nsv508364 CNV Loss 20534489

Relevant External Links for RGS7BP Gene

HapMap Linkage Disequilibrium report
RGS7BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS7BP Gene

Disorders for RGS7BP Gene

Relevant External Links for RGS7BP

Genetic Association Database (GAD)
RGS7BP
Human Genome Epidemiology (HuGE) Navigator
RGS7BP
genes like me logo Genes that share disorders with RGS7BP: view

No data available for UniProtKB/Swiss-Prot for RGS7BP Gene

Publications for RGS7BP Gene

  1. R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. (PMID: 15632198) Martemyanov K.A. … Arshavsky V.Y. (J. Biol. Chem. 2005) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Association analysis of RGS7BP gene polymorphisms with aspirin intolerance in asthmatic patients. (PMID: 21457877) Lee E.H. … Park C.S. (Ann. Allergy Asthma Immunol. 2011) 3
  4. Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors. (PMID: 21511947) Masuho I. … Martemyanov K.A. (J. Biol. Chem. 2011) 3
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48

Products for RGS7BP Gene

Sources for RGS7BP Gene

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