Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS7 Gene

protein-coding   GIFtS: 60
GCID: GC01M240938

regulator of G-protein signaling 7

(Previous name: regulator of G-protein signalling 7 )
 Explore 9 diseases affiliated with
RGS7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGS7    

Aliases
for RGS7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of G-Protein Signaling 71 2
Regulator Of G-Protein Signalling 71 2
Regulator Of G-Protein Signaling RGS72

External Ids:    HGNC: 100031   Entrez Gene: 60002   Ensembl: ENSG000001829017   OMIM: 6025175   UniProtKB: P498023   

Export aliases for RGS7 gene to outside databases

Previous GC identifers: GC01M239024 GC01M236392 GC01M237235 GC01M237980 GC01M237264 GC01M211396


Summaries
for RGS7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RGS7_HUMAN, P49802
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May
play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability
and the cellular responses to short-lived stimulations (By similarity)

Gene Wiki entry for RGS7


Genomic Views
for RGS7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS7 gene promoter:
         HOXA9B   HOXA9   HFH-3   ISGF-3   SRF (504 AA)   Meis-1b   FOXI1   STAT3   IRF-7A   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS7 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q43|1q23.1   Ensembl cytogenetic band:  1q43   HGNC cytogenetic band: 1q43

RGS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M240938:  view genomic region     (about GC identifiers)

Start:
 240,931,554 bp from pter      End:
 241,520,530 bp from pter
Size:
 588,977 bases      Orientation:
 minus strand

Proteins
for RGS7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RGS7_HUMAN, P49802 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 7  
Size: 495 amino acids; 57668 Da
Subunit: Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer
formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAPIN
2 PDB 3D structures from and Proteopedia for RGS7:
2A72 (3D)        2D9J (3D)    
Secondary accessions: Q5T3H4 Q8TD66 Q8TD67 Q8WW09 Q9UNU7 Q9Y6B9
Alternative splicing: 5 isoforms:  P49802-1   P49802-2   P49802-3   P49802-4   P49802-5   

Explore the universe of human proteins at neXtProt for RGS7: NX_P49802

Post-translational modifications:

  • Palmitoylated (By similarity)1
  • Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49802

    • RGS7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002915.3  
    ENSEMBL proteins: 
     ENSP00000355523   ENSP00000355522   ENSP00000355521   ENSP00000404399   ENSP00000341242  
     ENSP00000355520   ENSP00000384428   ENSP00000385508   ENSP00000331485   ENSP00000390138  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RGS7
    OriGene Protein Over-expression Lysate: RGS7
    OriGene Custom Protein Services for RGS7 
    GenScript Custom Purified and Recombinant Proteins Services for RGS7
    Novus Biologicals RGS7 Protein
    Novus Biologicals RGS7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RGS7

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol IEA--
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane IBA--


    RGS7 for ontologies           About GeneDecksing



    RGS7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RGS7 
    GenScript Custom Superior Antibodies Services for RGS7
    Novus Biologicals RGS7 Antibodies
    Search for Antibodies for RGS7 at Abcam  
    Uscn Antibodies for RGS7
    ThermoFisher Antibodies for RGS7

    Assay Products for RGS7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RGS7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RGS7

    Protein Domains /
    Families
    for RGS7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RGS7 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR024066 Regulat_G_prot_signal_dom1
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000591 DEP_dom

    Graphical View of Domain Structure for InterPro Entry P49802

    ProtoNet protein and cluster: P49802

    3 Blocks protein families:
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000591 Pleckstrin putative G-protein interacting domain
    IPB001770 Gamma G-protein (transducin) signature


    UniProtKB/Swiss-Prot: RGS7_HUMAN, P49802
    Similarity: Contains 1 DEP domain
    Similarity: Contains 1 G protein gamma domain
    Similarity: Contains 1 RGS domain


    Function
    for RGS7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RGS7_HUMAN, P49802
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
    them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May
    play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability
    and the cellular responses to short-lived stimulations (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RGS7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS7 (see all 10):
    hsa-miR-577 hsa-miR-203 hsa-miR-187* hsa-miR-650 hsa-miR-374c hsa-miR-338-5p hsa-miR-655 hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmid: RGS7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS7 (see all 7)
    OriGene shRNA RFP: RGS7
    OriGene siRNA: RGS7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RGS7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RGS7 (NM_002924)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS7 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RGS7
    Search LifeMap BioReagents cell lines for RGS7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS7

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0031681G-protein beta-subunit binding IEA--


    RGS7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RGS7:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for RGS7: Rgs7tm1Cjch Rgs7tm1.1Kama Rgs7tm1Lex
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rgs7):
     behavior/neurological  growth/size  homeostasis/metabolism  mortality/aging  nervous system 
     reproductive system  vision/eye 

    RGS7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RGS7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling_G-Protein alpha-i signaling cascades
    		G-protein signaling_G-Protein alpha-i signaling cascades1.00
    		G-protein signaling G-Protein alpha-i signaling cascades1.00
    2G-AlphaQ Signaling
    		G-AlphaQ Signaling1.00
    		G-AlphaI Signaling0.47
    3Calcium Regulation in the Cardiac Cell
    		Calcium Regulation in the Cardiac Cell1.00
    		Myometrial Relaxation and Contraction Pathways0.43
    4Activation of cAMP-Dependent PKA
    		cAMP Pathway0.77

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RGS7
        G-protein signaling G-Protein alpha-i signaling cascades

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS7
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    1 GeneGo (Thomson Reuters) Pathway for RGS7
        G-protein signaling G-Protein alpha-i signaling cascades

    2 BioSystems Pathways for RGS7 
        Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways



    RGS7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/169 Interacting proteins for RGS7 (P498022, 3 ENSP000003555204) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191742, 3, ENSP000002440074MINT-8112699 I2D: score=3 STRING: ENSP00000244007
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    GNAZP190863, ENSP000002489964I2D: score=2 STRING: ENSP00000248996
    PKD1P981613, ENSP000002623044I2D: score=2 STRING: ENSP00000262304
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway NAS--
    GO:0035556intracellular signal transduction IEA--
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity IBA--


    RGS7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGS7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS7
    2 Novoseek chemical compound relationships for RGS7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 4.02 1 15897264 (1)
    calcium 0.56 2 9572280 (1), 17511476 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS7 

    Transcripts
    for RGS7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGS7 gene: 
    NM_002924.4  

    Unigene Cluster for RGS7:

    Regulator of G-protein signaling 7
    Hs.655739  [show with all ESTs]
    Unigene Representative Sequence: NM_002924
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366565(uc001hyv.2 uc001hyw.2) ENST00000366564 ENST00000366563(uc001hyu.2 uc009xgn.1)
    ENST00000440928(uc010pyi.1) ENST00000348120(uc001hyt.2) ENST00000366562
    ENST00000407727 ENST00000401882 ENST00000331110(uc010pyh.2) ENST00000446183(uc010pyj.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: RGS7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS7 (see all 10):
    hsa-miR-577 hsa-miR-203 hsa-miR-187* hsa-miR-650 hsa-miR-374c hsa-miR-338-5p hsa-miR-655 hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmid: RGS7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS7 (see all 7)
    OriGene shRNA RFP: RGS7
    OriGene siRNA: RGS7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RGS7 (NM_002924)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS7 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGS7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS7

    Additional cDNA sequence: 

    AF090116.1 AF090117.1 AF493930.1 AF493931.1 AK294234.1 AK294354.1 AK314862.1 AY587875.1 
    BC022009.1 DQ139290.1 DQ139291.1 U32439.1 

    5 DOTS entries:

    DT.97837439  DT.413439  DT.92417937  DT.97837437  DT.92040513 

    24/43 AceView cDNA sequences (see all 43):

    BX431220 AL566862 BX441383 R85251 AF493930 BQ894441 AW872845 AW949375 
    AL537550 F12473 CR614351 AY587875 CB565901 Z42088 AL041546 AF090117 
    CD106482 CB118046 H41425 U32439 CB565902 NM_002924 AF493931 AF090116 

    GeneLoc Exon Structure


    Expression
    for RGS7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTCGTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RGS7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    AdiposeThoracic Perivascular AdiposeAdipose
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RGS7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS7

    SOURCE GeneReport for Unigene cluster: Hs.655739
        SABiosciences Custom PCR Arrays for RGS7
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGS7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS7

    Orthologs
    for RGS7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RGS7 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RGS71 regulator of G-protein signaling 7 85.42(n)
    96.26(a)    		   395620  NM_001198598.1  NP_001185527.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RGS76
    		 --
    		 88(a)
    		 1 ↔ 1
    		 1(216756910-216800432)
    zebrafish
    (Danio rerio)    		 Actinopterygii rgs71 regulator of G-protein signalling 7 75.98(n)
    88.86(a)    		   436814  NM_001002541.1  NP_001002541.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RSG71 , 3 regulation of G-protein coupled receptor
    protein more3
    Regulator of G-protein signalling 71    		 54(a)
    (best of 2)3
    57.98(n)1
    57.44(a)1    		   15B13
    326741  NM_078656.31  NP_523380.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea egl-101 , 3 G-protein beta subunit GPB-23
    Protein EGL-101    		 72(a)3
    58.75(n)1
    58.42(a)1    		   V(12459055-12465412)3
    1797071  NM_073724.41  NP_506125.11 


    ENSEMBL Gene Tree for RGS7 (if available)
    TreeFam Gene Tree for RGS7 (if available) 

    Paralogs
    for RGS7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS7 gene
    RGS142  RGS112  RGS122  RGS102  RGS62  RGS92  
    17 SIMAP similar genes for RGS7 using alignment to 6 protein entries:     RGS7_HUMAN (see all proteins):
    RGS6    RGS19    RGS17    RGS18    RGS1    RGS8
    RGS4    RGS20    RGS10    RGS3    RGS5    RGS9
    RGS13    RGS11    RGS21    RGS16    RGS2

    RGS7 for paralogs           About GeneDecksing



    Genomic Variants
    for RGS7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11270 NCBI SNPs in RGS7 are shown (see all 11270)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1147059991,2
    		C,F,other240939511(+) GATTTC/G/TCCCTG 3 G syn12EA NA 428
    rs750345901,2
    		--211434770(+) CAAATC/GTTAAT 1 -- int10--------
    rs66891691,2
    		C,F,A,H,--240938417(+) AAGAGA/GCACTG 1 -- ds500124Minor allele frequency- G:0.21NS EA NA WA CSA 2560
    rs754132141,2
    		--240938474(+) TGATTT/CAATAA 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1816086111,2
    		--240938598(+) TTGTGG/TTGTTC 1 -- ds50010--------
    rs1470122121,2
    		--240938612(+) CATGGA/GAGAAA 1 -- ds50010--------
    rs67003781,2
    		C,F,A,H,--240938621(+) AAAAGG/AATTAC 1 -- ds500112Minor allele frequency- A:0.17NS EA NA WA CSA 788
    rs1861218531,2
    		--240938687(+) ATCCAA/GGCTTG 1 -- ds50010--------
    rs120453491,2
    		C,F,H,--240938789(+) TAGCAT/CGGAAG 1 -- ds50014Minor allele frequency- C:0.01NS EA 416
    rs1841608211,2
    		--240938945(+) AAATGC/TGAGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RGS7 (240931554 - 241181554 bp, first 250kb of RGS7)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for RGS7
         2 CNVs: 97693 97692
         12 Indels: 60964 44541 44539 39703 24119 24120 44540 39704 42572 42249 60963 34382
    Human Gene Mutation Database (HGMD): RGS7

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS7
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS7

    Disorders / Diseases
    for RGS7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGS7 for disorders           About GeneDecksing

    OMIM gene information: 602517    OMIM disorders: --

    9 diseases for RGS7:    About MalaCards
    agoraphobia    panic disorder    cystic fibrosis    squamous cell carcinoma
    multiple sclerosis    fibrosis    ischemia    carcinoma
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: RGS7 (9 documents)

    Export disorders for RGS7 gene to outside databases

    Publications
    for RGS7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS7 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with RGS7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. (PubMed id 8548815)1, 2, 3 Koelle M.R. and Horvitz H.R. (1996)
    2. Snapin interacts with the N-terminus of regulator of G protein signaling 7. (PubMed id 12659861)1, 2, 9 Hunt R.A.... Young K.H. (2003)
    3. Interaction between RGS7 and polycystin. (PubMed id 10339594)1, 2, 9 Kim E.... Walz G. (1999)
    4. 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. (PubMed id 10862767)1, 2, 9 Benzing T....Walz G. (2000)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. (PubMed id 10339615)1, 2 Snow B.E.... Siderovski D.P. (1999)
    7. Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins. (PubMed id 10051672)1, 9 Levay K....Slepak V.Z. (1999)
    8. RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells. (PubMed id 9572280)1, 9 Shuey D.J....Cockett M.I. (1998)
    9. The Gbeta5-RGS7 complex selectively inhibits muscarin ic M3 receptor signaling via the interaction between the third intracellular lo op of the receptor and the DEP domain of RGS7. (PubMed id 19182865)1, 9 Sandiford S.L. and Slepak V.Z. (2009)
    10. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. (PubMed id 10521509)1, 9 Posner B.A.... Harris B.A. (1999)

    External Searches for RGS7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RGS7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6000 HGNC: 10003 AceView: RGS7 Ensembl:ENSG00000182901 euGenes: HUgn6000
    ECgene: RGS7 H-InvDB: RGS7

    Other Databases showing RGS7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RGS7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RGS7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RGS7 gene:
    Search GeneIP for patents involving RGS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RGS7 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RGS7  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS7   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS7  
     OriGene Protein Over-expression Lysate for RGS7   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RGS7   OriGene 3'-UTR Clone for RGS7  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS7   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS7  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for RGS7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RGS7   OriGene Custom Protein Services for RGS7  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGS7
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS7
     GenScript Custom Purified and Recombinant Proteins Services for RGS7 GenScript cDNA clones with any tag delivered in your preferred vector for RGS7
     GenScript Custom Assay Services for RGS7 GenScript Custom Superior Antibodies Services for RGS7
     GenScript Custom overexpressing Cell Line Services for RGS7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RGS7 promoter
     Search Chromatin IP Primers for RGS7
     RT2 qPCR Primer Assay in human, mouse, rat RGS7
     GNC Network for RGS7
     SABiosciences PCR Arrays including human, mouse, rat RGS7
     Search Tocris compounds for RGS7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RGS7 antibodies
     RGS7 proteins
     RGS7 lysates
     Search for Antibodies for RGS7 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RGS7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RGS7 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RGS7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS7
     SwitchGear 3'UTR luciferase reporter plasmids for RGS7
     SwitchGear Promoter luciferase reporter plasmids for RGS7
     ThermoFisher Antibodies for RGS7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS7
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RGS7 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4