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Aliases for RGS7 Gene

Aliases for RGS7 Gene

  • Regulator Of G-Protein Signaling 7 2 3
  • Regulator Of G-Protein Signalling 7 2

External Ids for RGS7 Gene

Summaries for RGS7 Gene

GeneCards Summary for RGS7 Gene

RGS7 (Regulator Of G-Protein Signaling 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include signal transducer activity and G-protein beta-subunit binding. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot for RGS7 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).

Gene Wiki entry for RGS7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS7 Gene

Genomics for RGS7 Gene

Genomic Location for RGS7 Gene

Start:
240,775,514 bp from pter
End:
241,357,230 bp from pter
Size:
581,717 bases
Orientation:
Minus strand

Genomic View for RGS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS7 Gene

Regulatory Elements for RGS7 Gene

Proteins for RGS7 Gene

  • Protein details for RGS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49802-RGS7_HUMAN
    Recommended name:
    Regulator of G-protein signaling 7
    Protein Accession:
    P49802
    Secondary Accessions:
    • Q5T3H4
    • Q8TD66
    • Q8TD67
    • Q8WW09
    • Q9UNU7
    • Q9Y6B9

    Protein attributes for RGS7 Gene

    Size:
    495 amino acids
    Molecular mass:
    57668 Da
    Quaternary structure:
    • Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAPIN.

    Three dimensional structures from OCA and Proteopedia for RGS7 Gene

    Alternative splice isoforms for RGS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS7 Gene

Proteomics data for RGS7 Gene at MOPED

Post-translational modifications for RGS7 Gene

No data available for DME Specific Peptides for RGS7 Gene

Domains for RGS7 Gene

Gene Families for RGS7 Gene

HGNC:
  • RGS :Regulators of G-protein signaling

UniProtKB/Swiss-Prot:

RGS7_HUMAN
Domain:
  • Contains 1 DEP domain.:
    • P49802
  • Contains 1 G protein gamma domain.:
    • P49802
  • Contains 1 RGS domain.:
    • P49802
genes like me logo Genes that share domains with RGS7: view

Function for RGS7 Gene

Molecular function for RGS7 Gene

UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).

Gene Ontology (GO) - Molecular Function for RGS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding --
GO:0031681 G-protein beta-subunit binding IPI 19376773
genes like me logo Genes that share ontologies with RGS7: view
genes like me logo Genes that share phenotypes with RGS7: view

Animal Models for RGS7 Gene

MGI Knock Outs for RGS7:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RGS7 Gene

Localization for RGS7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS7 Gene COMPARTMENTS Subcellular localization image for RGS7 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RGS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS7: view

Pathways for RGS7 Gene

genes like me logo Genes that share pathways with RGS7: view

Pathways by source for RGS7 Gene

Gene Ontology (GO) - Biological Process for RGS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway --
GO:0035556 intracellular signal transduction IEA --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RGS7: view

Compounds for RGS7 Gene

(2) Novoseek inferred chemical compound relationships for RGS7 Gene

Compound -log(P) Hits PubMed IDs
potassium 4.02 1
calcium 0.56 2
genes like me logo Genes that share compounds with RGS7: view

Transcripts for RGS7 Gene

Unigene Clusters for RGS7 Gene

Regulator of G-protein signaling 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS7 Gene

No ASD Table

Relevant External Links for RGS7 Gene

GeneLoc Exon Structure for
RGS7
ECgene alternative splicing isoforms for
RGS7

Expression for RGS7 Gene

mRNA expression in normal human tissues for RGS7 Gene

mRNA differential expression in normal tissues according to GTEx for RGS7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.1), Brain - Anterior cingulate cortex (BA24) (5.6), Brain - Nucleus accumbens (basal ganglia) (5.4), Brain - Cerebellar Hemisphere (5.3), Brain - Cortex (4.7), Brain - Caudate (basal ganglia) (4.1), and Brain - Putamen (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGS7 Gene

SOURCE GeneReport for Unigene cluster for RGS7 Gene Hs.655739

genes like me logo Genes that share expressions with RGS7: view

Orthologs for RGS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS7 36
  • 99.59 (n)
  • 99.79 (a)
RGS7 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS7 36
  • 93.32 (n)
  • 99.15 (a)
RGS7 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS7 36
  • 93.4 (n)
  • 98.53 (a)
RGS7 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs7 36
  • 90.76 (n)
  • 98.29 (a)
Rgs7 16
Rgs7 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS7 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS7 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs7 36
  • 90.42 (n)
  • 98.03 (a)
chicken
(Gallus gallus)
Aves RGS7 36
  • 85.38 (n)
  • 96.05 (a)
RGS7 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS7 37
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rgs7 36
  • 75.98 (n)
  • 88.86 (a)
rgs7 37
  • 88 (a)
OneToMany
RGS7 (2 of 2) 37
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006629 36
  • 58.96 (n)
  • 59.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta RSG7 36
  • 58.18 (n)
  • 57.78 (a)
RSG7 37
  • 39 (a)
OneToMany
RSG7 38
  • 54 (a)
CG7095 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-10 37
  • 39 (a)
OneToMany
egl-10 38
  • 72 (a)
Species with no ortholog for RGS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGS7 Gene

ENSEMBL:
Gene Tree for RGS7 (if available)
TreeFam:
Gene Tree for RGS7 (if available)

Paralogs for RGS7 Gene

Paralogs for RGS7 Gene

Selected SIMAP similar genes for RGS7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RGS7: view

Variants for RGS7 Gene

Sequence variations from dbSNP and Humsavar for RGS7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3083 -- 240,775,626(+) TTAAA(A/T)ATGGT utr-variant-3-prime
rs17555 -- 240,935,588(+) GAAAT(A/G)AGTCC intron-variant
rs166370 -- 240,871,393(+) AATTT(A/G)AGACC intron-variant
rs169021 -- 240,911,229(+) TCTCT(C/G)TCTTT intron-variant
rs169022 -- 240,934,811(-) CTTTA(A/G)AACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS7 Gene

Variant ID Type Subtype PubMed ID
nsv873361 CNV Gain 21882294
nsv470786 CNV Gain 18288195
nsv468650 CNV Gain 19166990
esv2726051 CNV Deletion 23290073
esv1049013 CNV Insertion 17803354
esv2630353 CNV Deletion 19546169
nsv873364 CNV Gain 21882294
nsv468661 CNV Gain 19166990
esv2669284 CNV Deletion 23128226
esv2663000 CNV Deletion 23128226
nsv873365 CNV Gain 21882294
nsv827587 CNV Loss 20364138
nsv470787 CNV Gain 18288195
esv2543708 CNV Deletion 19546169
esv2404546 CNV Deletion 18987734
esv3159 CNV Deletion 18987735
esv988740 CNV Deletion 20482838
esv2726062 CNV Deletion 23290073
esv8124 CNV Loss 19470904
esv1788930 CNV Deletion 17803354
nsv524932 CNV Loss 19592680
esv274863 CNV Gain+Loss 21479260
esv2726073 CNV Deletion 23290073
esv2310378 CNV Deletion 18987734
esv1003704 CNV Deletion 20482838
esv259467 OTHER Complex 20981092
esv1179588 CNV Insertion 17803354
nsv517999 CNV Loss 19592680
nsv833059 CNV Gain 17160897
dgv554n71 CNV Loss 21882294
esv2663733 CNV Deletion 23128226
esv2726084 CNV Deletion 23290073
nsv511746 CNV Loss 21212237
esv998180 CNV Deletion 20482838
esv2726095 CNV Deletion 23290073
esv2194065 CNV Deletion 18987734
esv5275 CNV Deletion 18987735
esv2726106 CNV Deletion 23290073
esv7124 CNV Loss 19470904
esv1012905 CNV Deletion 17803354
esv271995 CNV Insertion 20981092
esv275294 CNV Gain+Loss 21479260
esv2726117 CNV Deletion 23290073
nsv827598 CNV Loss 20364138
esv2664737 CNV Deletion 23128226
esv2726128 CNV Deletion 23290073
esv2726141 CNV Deletion 23290073
nsv160688 CNV Loss 16902084
nsv523209 CNV Loss 19592680
esv2675129 CNV Deletion 23128226

Relevant External Links for RGS7 Gene

HapMap Linkage Disequilibrium report
RGS7
Human Gene Mutation Database (HGMD)
RGS7

Disorders for RGS7 Gene

(1) University of Copenhagen DISEASES for RGS7 Gene

Relevant External Links for RGS7

Genetic Association Database (GAD)
RGS7
Human Genome Epidemiology (HuGE) Navigator
RGS7
genes like me logo Genes that share disorders with RGS7: view

No data available for UniProtKB/Swiss-Prot for RGS7 Gene

Publications for RGS7 Gene

  1. Interaction between RGS7 and polycystin. (PMID: 10339594) Kim E. … Walz G. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  2. 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. (PMID: 10862767) Benzing T. … Walz G. (J. Biol. Chem. 2000) 3 4 23
  3. Snapin interacts with the N-terminus of regulator of G protein signaling 7. (PMID: 12659861) Hunt R.A. … Young K.H. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  4. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. (PMID: 8548815) Koelle M.R. … Horvitz H.R. (Cell 1996) 2 3 4
  5. Association analysis of Rgs7 variants with panic disorder. (PMID: 18762858) Hohoff C. … Deckert J. (J Neural Transm 2009) 3 49

Products for RGS7 Gene

  • Addgene plasmids for RGS7

Sources for RGS7 Gene

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