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Aliases for RGS7 Gene

Aliases for RGS7 Gene

  • Regulator Of G Protein Signaling 7 2 3
  • Regulator Of G-Protein Signaling 7 2 5
  • Regulator Of G-Protein Signalling 7 2

External Ids for RGS7 Gene

Previous GeneCards Identifiers for RGS7 Gene

  • GC01M239024
  • GC01M236392
  • GC01M237235
  • GC01M237980
  • GC01M237264
  • GC01M240938
  • GC01M211396

Summaries for RGS7 Gene

GeneCards Summary for RGS7 Gene

RGS7 (Regulator Of G Protein Signaling 7) is a Protein Coding gene. Diseases associated with RGS7 include Uterine Benign Neoplasm and Reproductive Organ Benign Neoplasm. Among its related pathways are MAPK-Erk Pathway and Peptide ligand-binding receptors. GO annotations related to this gene include signal transducer activity and G-protein beta-subunit binding. An important paralog of this gene is RGS6.

UniProtKB/Swiss-Prot for RGS7 Gene

  • Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).

Gene Wiki entry for RGS7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS7 Gene

Genomics for RGS7 Gene

Regulatory Elements for RGS7 Gene

Enhancers for RGS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G241306 0.7 FANTOM5 15.1 +50.7 50687 0.2 ZNF571 ZSCAN4 MNT ZKSCAN1 ZNF544 ZNF239 IKZF1 TARDBP ZNF785 RGS7 RPL36P6
GH01G241413 0.6 ENCODE 8.9 -56.4 -56376 0.2 ZNF639 HINFP INSM2 MNT TSHZ1 FOSL1 ZNF629 FOS ZNF600 MAFK LOC105373230 RGS7
GH01G241227 0.3 FANTOM5 8.4 +129.7 129658 0.4 RGS7 GC01P241223 RPL36P6
GH01G241028 0.6 FANTOM5 3.4 +328.9 328886 0.4 JUND ZNF501 HNF4A YY1 RGS7 RPLP1P2 GC01P241061
GH01G241229 0.7 FANTOM5 2 +128.0 128007 0.4 ZNF692 ZEB2 HNF4A EP300 ZNF843 RAD21 FOXA1 RGS7 KMO GC01P241223 RPL36P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGS7 on UCSC Golden Path with GeneCards custom track

Promoters for RGS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022632 230 1200 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766

Genomic Location for RGS7 Gene

Chromosome:
1
Start:
240,775,514 bp from pter
End:
241,357,230 bp from pter
Size:
581,717 bases
Orientation:
Minus strand

Genomic View for RGS7 Gene

Genes around RGS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS7 Gene

Proteins for RGS7 Gene

  • Protein details for RGS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49802-RGS7_HUMAN
    Recommended name:
    Regulator of G-protein signaling 7
    Protein Accession:
    P49802
    Secondary Accessions:
    • Q5T3H4
    • Q8TD66
    • Q8TD67
    • Q8WW09
    • Q9UNU7
    • Q9Y6B9

    Protein attributes for RGS7 Gene

    Size:
    495 amino acids
    Molecular mass:
    57668 Da
    Quaternary structure:
    • Interacts with PKD1; this prevents rapid proteasomal degradation (PubMed:10339594). Interacts with GNB5 (PubMed:10521509, PubMed:10339615). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (PubMed:15897264). Interacts (phosphorylated form) with 14-3-3 protein YWHAQ (PubMed:10862767). Interacts with SNAPIN (PubMed:12659861). Interacts with GNAI1 (PubMed:18434541). Interacts with GNAO1, GNAI3 and GNAZ (By similarity).

    Three dimensional structures from OCA and Proteopedia for RGS7 Gene

    Alternative splice isoforms for RGS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS7 Gene

Post-translational modifications for RGS7 Gene

No data available for DME Specific Peptides for RGS7 Gene

Domains & Families for RGS7 Gene

Gene Families for RGS7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS7: view

No data available for UniProtKB/Swiss-Prot for RGS7 Gene

Function for RGS7 Gene

Molecular function for RGS7 Gene

UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).

Gene Ontology (GO) - Molecular Function for RGS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005096 GTPase activator activity IDA,IEA 10521509
GO:0031681 G-protein beta-subunit binding IPI 19376773
genes like me logo Genes that share ontologies with RGS7: view
genes like me logo Genes that share phenotypes with RGS7: view

Animal Models for RGS7 Gene

MGI Knock Outs for RGS7:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RGS7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RGS7 Gene

Localization for RGS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS7 Gene

Cytoplasm, cytosol. Cytoplasm. Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264). {ECO:0000269 PubMed:10339594, ECO:0000269 PubMed:15897264}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS7 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4

Gene Ontology (GO) - Cellular Components for RGS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IEA 10521509
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RGS7: view

Pathways & Interactions for RGS7 Gene

genes like me logo Genes that share pathways with RGS7: view

Gene Ontology (GO) - Biological Process for RGS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IDA 10521509
genes like me logo Genes that share ontologies with RGS7: view

No data available for SIGNOR curated interactions for RGS7 Gene

Drugs & Compounds for RGS7 Gene

(2) Drugs for RGS7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RGS7: view

Transcripts for RGS7 Gene

Unigene Clusters for RGS7 Gene

Regulator of G-protein signaling 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RGS7

Alternative Splicing Database (ASD) splice patterns (SP) for RGS7 Gene

No ASD Table

Relevant External Links for RGS7 Gene

GeneLoc Exon Structure for
RGS7
ECgene alternative splicing isoforms for
RGS7

Expression for RGS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS7 Gene

mRNA differential expression in normal tissues according to GTEx for RGS7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.4), Brain - Cerebellar Hemisphere (x5.3), Brain - Cortex (x4.7), Brain - Caudate (basal ganglia) (x4.1), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for RGS7 Gene

This gene is overexpressed in Brain (54.0) and Frontal cortex (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RGS7 Gene



Protein tissue co-expression partners for RGS7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RGS7 Gene:

RGS7

SOURCE GeneReport for Unigene cluster for RGS7 Gene:

Hs.655739

Evidence on tissue expression from TISSUES for RGS7 Gene

  • Nervous system(4.7)
  • Eye(2)
genes like me logo Genes that share expression patterns with RGS7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS7 Gene

Orthologs for RGS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS7 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia RGS7 34 35
  • 93.4 (n)
cow
(Bos Taurus)
Mammalia RGS7 34 35
  • 93.32 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS7 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS7 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs7 34 16 35
  • 90.76 (n)
rat
(Rattus norvegicus)
Mammalia Rgs7 34
  • 90.42 (n)
chicken
(Gallus gallus)
Aves RGS7 34 35
  • 85.38 (n)
lizard
(Anolis carolinensis)
Reptilia RGS7 35
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RGS7 (2 of 2) 35
  • 82 (a)
OneToMany
rgs7 34 35
  • 75.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006629 34
  • 58.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta RSG7 36 34 35
  • 58.18 (n)
CG7095 36
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-10 36 35
  • 72 (a)
Species where no ortholog for RGS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RGS7 Gene

ENSEMBL:
Gene Tree for RGS7 (if available)
TreeFam:
Gene Tree for RGS7 (if available)

Paralogs for RGS7 Gene

Paralogs for RGS7 Gene

genes like me logo Genes that share paralogs with RGS7: view

Variants for RGS7 Gene

Sequence variations from dbSNP and Humsavar for RGS7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000001505 -- 240,955,307(+) GTTGG(C/T)TTTAG intron-variant
rs1000001889 -- 241,069,591(+) TAACA(C/T)GCTTC intron-variant
rs1000005383 -- 241,317,335(+) ACATG(C/T)GAATT intron-variant
rs1000007228 -- 241,277,746(+) CAAAG(A/G)GATAC intron-variant
rs1000012391 -- 241,357,534(+) AGGTG(A/G)GTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RGS7 Gene

Variant ID Type Subtype PubMed ID
dgv310n106 CNV deletion 24896259
dgv311n106 CNV deletion 24896259
esv1003704 CNV deletion 20482838
esv1012905 CNV deletion 17803354
esv1049013 CNV insertion 17803354
esv1179588 CNV insertion 17803354
esv1788930 CNV deletion 17803354
esv2194065 CNV deletion 18987734
esv2310378 CNV deletion 18987734
esv2404546 CNV deletion 18987734
esv2543708 CNV deletion 19546169
esv2630353 CNV deletion 19546169
esv2663000 CNV deletion 23128226
esv2663733 CNV deletion 23128226
esv2664737 CNV deletion 23128226
esv2669284 CNV deletion 23128226
esv2675129 CNV deletion 23128226
esv2726051 CNV deletion 23290073
esv2726062 CNV deletion 23290073
esv2726073 CNV deletion 23290073
esv2726084 CNV deletion 23290073
esv2726095 CNV deletion 23290073
esv2726106 CNV deletion 23290073
esv2726117 CNV deletion 23290073
esv2726128 CNV deletion 23290073
esv2726141 CNV deletion 23290073
esv274863 CNV gain+loss 21479260
esv275294 CNV gain+loss 21479260
esv2846236 CNV deletion 24192839
esv3159 CNV loss 18987735
esv3302493 CNV tandem duplication 20981092
esv3307721 CNV mobile element insertion 20981092
esv3387257 CNV duplication 20981092
esv3423558 CNV insertion 20981092
esv3437950 CNV duplication 20981092
esv3549432 CNV deletion 23714750
esv3549443 CNV deletion 23714750
esv3549455 CNV deletion 23714750
esv3549466 CNV deletion 23714750
esv3578508 CNV loss 25503493
esv3578509 CNV loss 25503493
esv3589322 CNV loss 21293372
esv3589323 CNV loss 21293372
esv3589326 CNV loss 21293372
esv3589327 CNV loss 21293372
esv3589329 CNV loss 21293372
esv3589331 CNV loss 21293372
esv3589332 CNV gain 21293372
esv3589335 CNV loss 21293372
esv3891270 CNV loss 25118596
esv5275 CNV loss 18987735
esv7124 CNV loss 19470904
esv8124 CNV loss 19470904
esv988740 CNV deletion 20482838
esv998180 CNV deletion 20482838
nsv1001342 CNV gain 25217958
nsv1002214 CNV gain 25217958
nsv1015107 CNV loss 25217958
nsv1068641 CNV deletion 25765185
nsv1068991 CNV deletion 25765185
nsv1068992 CNV deletion 25765185
nsv1122466 CNV deletion 24896259
nsv1137857 CNV deletion 24896259
nsv1137858 CNV deletion 24896259
nsv1144448 CNV deletion 24896259
nsv1146617 CNV deletion 26484159
nsv1150553 CNV deletion 26484159
nsv1160478 CNV deletion 26073780
nsv160688 CNV deletion 16902084
nsv468650 CNV gain 19166990
nsv468661 CNV gain 19166990
nsv470786 CNV gain 18288195
nsv470787 CNV gain 18288195
nsv478823 CNV novel sequence insertion 20440878
nsv511746 CNV loss 21212237
nsv517999 CNV loss 19592680
nsv523209 CNV loss 19592680
nsv524932 CNV loss 19592680
nsv549456 CNV gain 21841781
nsv549457 CNV gain 21841781
nsv549458 CNV gain 21841781
nsv549459 CNV loss 21841781
nsv549460 CNV gain 21841781
nsv827587 CNV loss 20364138
nsv827598 CNV loss 20364138
nsv833059 CNV gain 17160897
nsv945399 CNV duplication 23825009
nsv947474 CNV duplication 23825009
nsv954004 CNV deletion 24416366
nsv956695 CNV deletion 24416366
nsv958711 CNV deletion 24416366
nsv958757 CNV deletion 24416366
nsv998437 CNV loss 25217958

Variation tolerance for RGS7 Gene

Residual Variation Intolerance Score: 6.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS7 Gene

Human Gene Mutation Database (HGMD)
RGS7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS7 Gene

Disorders for RGS7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RGS7 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RGS7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGS7

Genetic Association Database (GAD)
RGS7
Human Genome Epidemiology (HuGE) Navigator
RGS7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS7
genes like me logo Genes that share disorders with RGS7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS7 Gene

Publications for RGS7 Gene

  1. Snapin interacts with the N-terminus of regulator of G protein signaling 7. (PMID: 12659861) Hunt R.A. … Young K.H. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  2. 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. (PMID: 10862767) Benzing T. … Walz G. (J. Biol. Chem. 2000) 3 4 22 64
  3. Interaction between RGS7 and polycystin. (PMID: 10339594) Kim E. … Walz G. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 22 64
  4. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. (PMID: 10521509) Posner B.A. … Harris B.A. (J. Biol. Chem. 1999) 3 4 22 64
  5. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. (PMID: 8548815) Koelle M.R. … Horvitz H.R. (Cell 1996) 2 3 4 64

Products for RGS7 Gene

  • Addgene plasmids for RGS7

Sources for RGS7 Gene

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