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Aliases for RGS6 Gene

Aliases for RGS6 Gene

  • Regulator Of G-Protein Signaling 6 2 3
  • Regulator Of G-Protein Signalling 6 2 3
  • S914 3 4
  • GTPase Activating Protein 3
  • WUGSC:H_DJ0283M22.1 3
  • WUGSC:H_DJ1108A12.1 3
  • H_DJ1108A12.1 3
  • GAP 3

External Ids for RGS6 Gene

Summaries for RGS6 Gene

Entrez Gene Summary for RGS6 Gene

  • This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]

GeneCards Summary for RGS6 Gene

RGS6 (Regulator Of G-Protein Signaling 6) is a Protein Coding gene. Diseases associated with RGS6 include sick sinus syndrome. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include signal transducer activity and GTPase activator activity. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot for RGS6 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer.

Gene Wiki entry for RGS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS6 Gene

Genomics for RGS6 Gene

Genomic Location for RGS6 Gene

Start:
71,932,100 bp from pter
End:
72,566,530 bp from pter
Size:
634,431 bases
Orientation:
Plus strand

Genomic View for RGS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS6 Gene

Regulatory Elements for RGS6 Gene

Proteins for RGS6 Gene

  • Protein details for RGS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49758-RGS6_HUMAN
    Recommended name:
    Regulator of G-protein signaling 6
    Protein Accession:
    P49758
    Secondary Accessions:
    • C9JE95
    • F8W7W5
    • O75576
    • O75577
    • Q7Z4K3
    • Q7Z4K4
    • Q7Z4K5
    • Q7Z4K6
    • Q8TE13
    • Q8TE14
    • Q8TE15
    • Q8TE16
    • Q8TE17
    • Q8TE18
    • Q8TE19
    • Q8TE20
    • Q8TE21
    • Q8TE22
    • Q9UDS8
    • Q9UDT0
    • Q9Y245
    • Q9Y647

    Protein attributes for RGS6 Gene

    Size:
    472 amino acids
    Molecular mass:
    54423 Da
    Quaternary structure:
    • Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).
    SequenceCaution:
    • Sequence=AAC42001.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGS6 Gene

neXtProt entry for RGS6 Gene

Proteomics data for RGS6 Gene at MOPED

Post-translational modifications for RGS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS6 Gene

Domains for RGS6 Gene

Gene Families for RGS6 Gene

HGNC:
  • RGS :Regulators of G-protein signaling

UniProtKB/Swiss-Prot:

RGS6_HUMAN
Domain:
  • The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.:
    • P49758
  • Contains 1 DEP domain.:
    • P49758
  • Contains 1 G protein gamma domain.:
    • P49758
  • Contains 1 RGS domain.:
    • P49758
genes like me logo Genes that share domains with RGS6: view

Function for RGS6 Gene

Molecular function for RGS6 Gene

GENATLAS Biochemistry: negative regulator of G protein signaling 6,functioning as GTPase-activating protein for G protein alpha i and q subunits,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer.

Gene Ontology (GO) - Molecular Function for RGS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 22939624
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with RGS6: view

Phenotypes for RGS6 Gene

genes like me logo Genes that share phenotypes with RGS6: view

Animal Models for RGS6 Gene

MGI Knock Outs for RGS6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RGS6 Gene

Localization for RGS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS6 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS6 Gene COMPARTMENTS Subcellular localization image for RGS6 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RGS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005794 Golgi apparatus IEA --
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane IBA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with RGS6: view

Pathways for RGS6 Gene

genes like me logo Genes that share pathways with RGS6: view

Gene Ontology (GO) - Biological Process for RGS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10083744
GO:0035556 intracellular signal transduction IEA --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity TAS 10083744
genes like me logo Genes that share ontologies with RGS6: view

Transcripts for RGS6 Gene

Unigene Clusters for RGS6 Gene

Regulator of G-protein signaling 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS6 Gene

No ASD Table

Relevant External Links for RGS6 Gene

GeneLoc Exon Structure for
RGS6
ECgene alternative splicing isoforms for
RGS6

Expression for RGS6 Gene

mRNA expression in normal human tissues for RGS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS6 Gene

This gene is overexpressed in Brain - Cortex (5.3) and Brain - Frontal Cortex (BA9) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGS6 Gene

SOURCE GeneReport for Unigene cluster for RGS6 Gene Hs.509872

genes like me logo Genes that share expressions with RGS6: view

Orthologs for RGS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS6 36
  • 99.73 (n)
  • 100 (a)
RGS6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS6 36
  • 93.13 (n)
  • 97.96 (a)
RGS6 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS6 36
  • 92.86 (n)
  • 97.76 (a)
RGS6 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs6 36
  • 92.02 (n)
  • 97.67 (a)
Rgs6 16
Rgs6 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS6 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS6 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs6 36
  • 91.88 (n)
  • 98.09 (a)
chicken
(Gallus gallus)
Aves RGS6 36
  • 83.33 (n)
  • 92.8 (a)
RGS6 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS6 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68862 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs6 36
  • 78.66 (n)
  • 87.73 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs6 36
  • 74.91 (n)
  • 82.41 (a)
rgs6 37
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003718 36
  • 57.72 (n)
  • 56.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta RSG7 37
  • 39 (a)
OneToMany
RSG7 38
  • 54 (a)
CG7095 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-10 36
  • 55.7 (n)
  • 53.42 (a)
egl-10 37
  • 39 (a)
OneToMany
egl-10 38
  • 62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2539 36
Species with no ortholog for RGS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS6 Gene

ENSEMBL:
Gene Tree for RGS6 (if available)
TreeFam:
Gene Tree for RGS6 (if available)

Paralogs for RGS6 Gene

Paralogs for RGS6 Gene

Selected SIMAP similar genes for RGS6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGS6: view

Variants for RGS6 Gene

Sequence variations from dbSNP and Humsavar for RGS6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3291 -- 72,563,702(-) TTTAC(A/G)TACAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs20838 -- 72,177,818(-) AGTAA(A/T)TTCCA intron-variant
rs36318 -- 71,942,635(-) GGGAA(A/G)TGGTA intron-variant
rs36319 -- 71,942,298(-) GTAAC(A/G)GTGAA intron-variant
rs36320 -- 71,936,697(-) caaca(A/G)catgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS6 Gene

Variant ID Type Subtype PubMed ID
esv2748857 CNV Deletion 23290073
esv1941080 CNV Deletion 18987734
esv2748858 CNV Deletion 23290073
esv989746 CNV Deletion 20482838
esv1245851 CNV Deletion 17803354
nsv85657 CNV Loss 16902084
nsv902076 CNV Gain 21882294
dgv1956n71 CNV Gain 21882294
nsv518009 CNV Loss 19592680
nsv437796 CNV Loss 16327808
essv3245 CNV CNV 17122850
dgv640e1 CNV Complex 17122850
esv2664196 CNV Deletion 23128226
esv2748859 CNV Deletion 23290073
nsv819274 CNV Loss 19587683
nsv442345 CNV CNV 18776908
nsv1346 CNV Insertion 18451855
esv259574 OTHER Complex 20981092
esv259732 OTHER Complex 20981092
esv9494 CNV Gain 19470904
esv275248 CNV Loss 21479260
nsv1347 CNV Insertion 18451855
nsv518320 CNV Loss 19592680

Relevant External Links for RGS6 Gene

HapMap Linkage Disequilibrium report
RGS6
Human Gene Mutation Database (HGMD)
RGS6

Disorders for RGS6 Gene

(1) MalaCards Diseases for RGS6 Gene

Search for RGS6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RGS6 Gene

Relevant External Links for RGS6

Genetic Association Database (GAD)
RGS6
Human Genome Epidemiology (HuGE) Navigator
RGS6
genes like me logo Genes that share disorders with RGS6: view

No data available for UniProtKB/Swiss-Prot for RGS6 Gene

Publications for RGS6 Gene

  1. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. (PMID: 10521509) Posner B.A. … Harris B.A. (J. Biol. Chem. 1999) 3 4 23
  2. Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants. (PMID: 12761221) Chatterjee T.K. … Fisher R.A. (J. Biol. Chem. 2003) 3 4 23
  3. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. (PMID: 16691626) Gu J. … Berman D.M. (Cancer 2006) 3 23 49
  4. Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins. (PMID: 12761220) Chatterjee T.K. … Fisher R.A. (J. Biol. Chem. 2003) 3 23
  5. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. (PMID: 21300955) Dehghan A. … Chasman D.I. (Circulation 2011) 3 49

Products for RGS6 Gene

Sources for RGS6 Gene

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