Aliases for RGS6 Gene
External Ids for RGS6 Gene
Previous GeneCards Identifiers for RGS6 Gene
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
GeneCards Summary for RGS6 Gene
RGS6 (Regulator Of G Protein Signaling 6) is a Protein Coding gene. Diseases associated with RGS6 include Early-Onset Familial Alzheimer Disease and Alcoholic Cardiomyopathy. Among its related pathways are Signaling by GPCR and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include signal transducer activity and protein domain specific binding. An important paralog of this gene is RGS7.
UniProtKB/Swiss-Prot for RGS6 Gene
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509).