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RGS5 Gene

protein-coding   GIFtS: 60
GCID: GC01M163080

Regulator Of G-Protein Signaling 5

(Previous name: regulator of G-protein signalling 5)
  See RGS5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Regulator Of G-Protein Signaling 51 2     MSTP0322
Regulator Of G-Protein Signalling 51     MSTP0922
MST0922     MSTP1062
MST1062     MSTP1292
MST1292     

External Ids:    HGNC: 100011   Entrez Gene: 84902   Ensembl: ENSG000001432487   OMIM: 6032765   UniProtKB: O155393   
ORGUL members:         

Export aliases for RGS5 gene to outside databases

Previous GC identifers: GC01M160750 GC01M158766 GC01M159776 GC01M160299 GC01M159843 GC01M161378 GC01M134357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS5 Gene:
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal
transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase
activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the
induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to
elevated blood pressure. Alternatively spliced transcript variants have been identified. (provided by RefSeq, Dec
2011)

GeneCards Summary for RGS5 Gene:
RGS5 (regulator of G-protein signaling 5) is a protein-coding gene. Diseases associated with RGS5 include benign paroxysmal positional nystagmus, and hypoxia. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS5_HUMAN, O15539
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By
similarity)

Gene Wiki entry for RGS5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS5 gene promoter:
         TBP   NF-1   C/EBPbeta   Pax-6   FOXO3   FOXO3b   MEF-2A   FOXO3a   Sox9   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS5 promoter sequence
   Search Chromatin IP Primers for RGS5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1

RGS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M163080:  view genomic region     (about GC identifiers)

Start:
163,080,911 bp from pter      End:
163,291,577 bp from pter
Size:
210,667 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGS5_HUMAN, O15539 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 5  
Size: 181 amino acids; 20946 Da
1 PDB 3D structure from and Proteopedia for RGS5:
2CRP (3D)    
Secondary accessions: E9PMP5 Q53XA9 Q599J0
Alternative splicing: 3 isoforms:  O15539-1   O15539-2   O15539-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGS5: NX_O15539

Explore proteomics data for RGS5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001182232.1  NP_001241677.1  NP_001241678.1  NP_003608.1  

    ENSEMBL proteins: 
     ENSP00000319308   ENSP00000356879   ENSP00000433001   ENSP00000432313   ENSP00000435861  

    RGS5 Human Recombinant Protein Products:

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    Novus Biologicals RGS5 Lysates
    Sino Biological Recombinant Protein for RGS5
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RGS5
    Cloud-Clone Corp. Proteins for RGS5

     
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    antibodies-online proteins for RGS5 (9 products) 

     
    antibodies-online peptides for RGS5

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    antibodies-online antibodies for RGS5 (60 products) 

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    Cloud-Clone Corp. CLIAs for RGS5
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    antibodies-online kits for RGS5 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry O15539

    ProtoNet protein and cluster: O15539

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS5_HUMAN, O15539
    Similarity: Contains 1 RGS domain


    Find genes that share domains with RGS5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS5_HUMAN, O15539
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By
    similarity)

         Genatlas biochemistry entry for RGS5:
    negative regulator of G protein signaling 5,functioning as GTPase activating protein for G protein alpha i and q
    subunits,abundantly expressed in heart,lung,skeletal muscle,small intestine,C elegans EGL-10 and yeast SST2
    homolog

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
         
    Find genes that share ontologies with RGS5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RGS5:
     Decreased Salmonella enterica   Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Rgs5):
     adipose tissue  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  no phenotypic analysis  normal  tumorigenesis 

    Find genes that share phenotypes with RGS5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgs5tm1.1Rgan for RGS5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS5
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGS5

    miRNA
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    miRTarBase miRNAs that target RGS5:
    hsa-mir-142-3p (MIRT021577)

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    Selected qRT-PCR Assays for microRNAs that regulate RGS5 (see all 26):
    hsa-miR-124* hsa-miR-320a hsa-miR-875-3p hsa-miR-4307 hsa-miR-4263 hsa-miR-628-3p hsa-miR-4260 hsa-miR-1257
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Sino Biological Human cDNA Clone for RGS5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGS5_HUMAN, O15539: Isoform 1: Cytoplasm. Membrane
    RGS5_HUMAN, O15539: Isoform 2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IBA--

    Find genes that share ontologies with RGS5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS5 About    
    See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    3Activation of cAMP-Dependent PKA
    cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS5
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    2 BioSystems Pathways for RGS5
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS5
    Interactions:

        GeneGlobe Interaction Network for RGS5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for RGS5 (O155393 ENSP000003193084) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=2 STRING: ENSP00000262493
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    GNAI2P048993, ENSP000003129994I2D: score=2 STRING: ENSP00000312999
    GNAI3P087543, ENSP000003588674I2D: score=2 STRING: ENSP00000358867
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS10471929
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS10471929
    GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway ----

    Find genes that share ontologies with RGS5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS5

    1 Novoseek inferred chemical compound relationship for RGS5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 28.7 1 16839744 (1)



    Find genes that share compounds with RGS5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGS5 gene (5 alternative transcripts): 
    NM_001195303.2  NM_001254748.1  NM_001254749.1  NM_003617.3  NM_025226.1  

    Unigene Cluster for RGS5:

    Regulator of G-protein signaling 5
    Hs.24950  [show with all ESTs]
    Unigene Representative Sequence: NM_001254749
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469495 ENST00000313961(uc021pdt.1 uc001gcn.3 uc009wvb.3 uc021pdu.1)
    ENST00000367903 ENST00000530507 ENST00000527988 ENST00000531954 ENST00000525894
    ENST00000531476 ENST00000530241 ENST00000534288 ENST00000428971
    miRNA
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    Block miRNA regulation of human, mouse, rat RGS5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGS5 (see all 26):
    hsa-miR-124* hsa-miR-320a hsa-miR-875-3p hsa-miR-4307 hsa-miR-4263 hsa-miR-628-3p hsa-miR-4260 hsa-miR-1257
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      QuantiTect SYBR Green Assays in human, mouse, rat RGS5
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    Additional mRNA sequence: 

    AB008109.1 AF113212.1 AF159570.1 AF172821.1 AF173551.1 AF176919.1 AF493929.1 AJ891044.1 
    AK026775.1 AK315357.1 AL157502.1 BC029357.1 BC030059.1 BX537427.1 

    Selected DOTS entries (see all 32):

    DT.454413  DT.87078932  DT.100697498  DT.118879  DT.95170879  DT.95263781  DT.100697493  DT.92407095 
    DT.121444527  DT.121444614  DT.121444507  DT.95258230  DT.100864129  DT.101958879  DT.121444480  DT.121444574 
    DT.100683459  DT.100697484  DT.100860237  DT.121444502  DT.121444511  DT.121444563  DT.100656827  DT.100664659 

    Selected AceView cDNA sequences (see all 888):

    AW026632 BQ050597 CR600297 AA348466 D57280 AU130764 CA391795 AI936599 
    AA402177 AW029427 AI270505 BI494220 BI819193 AF159570 AA668470 H71467 
    CR613029 D57888 AA488074 BE326810 BF515047 AL515897 BE890175 CA946883 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RGS5 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
    SP1:                    -     -                                   -     -                     
    SP2:                    -     -                                         -                     
    SP3:                    -     -                                                               
    SP4:                          -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RGS5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGAGACA
    RGS5 Expression
    About this image


    RGS5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 31) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Cardiac Crescent Cells Cardiac Crescent
             Heart Tube
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Paraxial Mesoderm Cells Branchial Arch 1
             Mandibular Process
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Smooth muscle cells
    RGS5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24950
        Custom PCR Arrays for RGS5
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RGS5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RGS5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs51 , 5 regulator of G-protein signaling 51, 5 89.69(n)1
    90.06(a)1
      1 (76.84 cM)5
    197371  NM_009063.31  NP_033089.21 
     1696555015 
    chicken
    (Gallus gallus)
    Aves RGS51 regulator of G-protein signaling 5 80.29(n)
    84.53(a)
      769998  XM_001233313.3  XP_001233314.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS56
    regulator of G-protein signaling 5
    81(a)
    1 ↔ 1
    4(71221035-71244291)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rgs51 regulator of G-protein signaling 5 74.22(n)
    80.11(a)
      780219  NM_001079294.1  NP_001072762.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj30h052 wufj30h05 76.81(n)   335630  BC054594.1 


    ENSEMBL Gene Tree for RGS5 (if available)
    TreeFam Gene Tree for RGS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS5 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS162  RGS172  
    RGS12  RGS182  RGS132  RGS42  
    Selected SIMAP similar genes for RGS5 using alignment to 3 protein entries:     RGS5_HUMAN (see all proteins) (see all similar genes):
    RGS4    RGS8    RGS21    RGS3    RGS17    RGS16
    RGS18    RGS1    RGS13    RGS6    RGS20    RGS10
    RGS19    RGS2    RGS9    RGS7    AXIN1    RGS11

    Find genes that share paralogs with RGS5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS5 (see all 3490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113641211,2
    C,F--163112343(+) ACATTA/-AAAAA 4 -- ut312Minor allele frequency- -:0.50NA CSA 4
    rs772468191,2
    C--163116031(+) ATTAC-/T/TT  
            
    TTTTT
    8 -- ut310--------
    rs613278971,2
    C--163117599(+) AATATG/-TATAT 4 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs782102501,2
    C--163117599(+) AATAT-/GTTATA 4 -- int10--------
    rs667321821,2
    C--163117600(+) ATATT-/GATATG 4 -- int10--------
    rs44393371,2
    A--163117711(+) ttcttC/Tttttt 4 -- int1 trp30--------
    rs353699711,2
    C--163122758(+) AGAGA-/AG/GA 
            
    TTTAC
    4 -- int11NA 2
    rs38357311,2
    C--163123619(-) TATAT-/ATGTGTG 4 -- int10--------
    rs561391071,2
    C--163123620(+) ATATA-/AT/TA 
            
    AACCA
    4 -- int11NA 2
    rs1118024741,2
    C,F--163128665(+) GGGAGC/TGCTAC 4 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for RGS5 (163080911 - 163291577 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RGS5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS5
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603276   
    OMIM disorders: 145500  
    2 diseases for RGS5:    
    About MalaCards
    benign paroxysmal positional nystagmus    hypoxia

    1 disease from the University of Copenhagen DISEASES database for RGS5:
    Benign paroxysmal positional nystagmus

    Find genes that share disorders with RGS5           About GenesLikeMe

    Genetic Association Database (GAD): RGS5
    Human Genome Epidemiology (HuGE) Navigator: RGS5 (11 documents)

    Export disorders for RGS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS5 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with RGS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene. (PubMed id 9747037)1, 2, 3, 9 Seki N.... Hori T. (J. Hum. Genet. 1998)
    2. Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. (PubMed id 15670159)1, 2, 9 Liang Y.... Woodwrad D.F. (FEBS J. 2005)
    3. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PubMed id 18262772)1, 4, 9 Campbell D.B....Sullivan P.F. (Schizophr. Res. 2008)
    4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (Carcinogenesis 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese. (PubMed id 19863299)1, 4 Xiao B....Zhu D.L. (Clin. Chem. Lab. Med. 2009)
    9. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    10. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8490 HGNC: 10001 AceView: RGS5 Ensembl:ENSG00000143248 euGenes: HUgn8490
    ECgene: RGS5 H-InvDB: RGS5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS5 gene:
    Search GeneIP for patents involving RGS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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