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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS5 Gene

protein-coding   GIFtS: 56
GCID: GC01M163080

regulator of G-protein signaling 5

(Previous name: regulator of G-protein signalling 5 )
 Explore 18 diseases affiliated with
RGS5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGS5    

Aliases
for RGS5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of G-Protein Signaling 51 2     MSTP0322
Regulator Of G-Protein Signalling 51     MSTP0922
MST0922     MSTP1062
MST1062     MSTP1292
MST1292     

External Ids:    HGNC: 100011   Entrez Gene: 84902   Ensembl: ENSG000001432487   OMIM: 6032765   UniProtKB: O155393   

Export aliases for RGS5 gene to outside databases

Previous GC identifers: GC01M160750 GC01M158766 GC01M159776 GC01M160299 GC01M159843 GC01M161378 GC01M134357


Summaries
for RGS5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RGS5:
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal
transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase
activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the
induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated
blood pressure. Alternatively spliced transcript variants have been identified. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: RGS5_HUMAN, O15539
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity)

Gene Wiki entry for RGS5


Genomic Views
for RGS5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS5 gene promoter:
         TBP   NF-1   C/EBPbeta   Pax-6   FOXO3   FOXO3b   MEF-2A   FOXO3a   Sox9   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS5 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1

RGS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M163080:  view genomic region     (about GC identifiers)

Start:
 163,080,911 bp from pter      End:
 163,187,426 bp from pter
Size:
 106,516 bases      Orientation:
 minus strand

Proteins
for RGS5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RGS5_HUMAN, O15539 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 5  
Size: 181 amino acids; 20946 Da
Subcellular location: Isoform 1: Cytoplasm. Membrane
Subcellular location: Isoform 2: Cytoplasm
1 PDB 3D structure from and Proteopedia for RGS5:
2CRP (3D)    
Secondary accessions: E9PMP5 Q53XA9 Q599J0
Alternative splicing: 3 isoforms:  O15539-1   O15539-2   O15539-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGS5: NX_O15539

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15539

    • RGS5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001182232.1  NP_001241677.1  NP_001241678.1  NP_003608.1  

    ENSEMBL proteins: 
     ENSP00000319308   ENSP00000356879   ENSP00000433001   ENSP00000432313   ENSP00000435861  

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    ProSpec Recombinant Protein for RGS5
    Uscn Proteins for RGS5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IBA--


    RGS5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RGS5

    Protein Domains /
    Families
    for RGS5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RGS5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry O15539

    ProtoNet protein and cluster: O15539

    1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS5_HUMAN, O15539
    Similarity: Contains 1 RGS domain


    Function
    for RGS5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RGS5_HUMAN, O15539
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
    them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity)

         Genatlas biochemistry entry for RGS5:
    negative regulator of G protein signaling 5,functioning as GTPase activating protein for G protein alpha i and q
    subunits,abundantly expressed in heart,lung,skeletal muscle,small intestine,C elegans EGL-10 and yeast SST2 homolog

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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--


    RGS5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RGS5:
     Decreased Salmonella enterica   Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Rgs5tm1.1Rgan for RGS5
         10 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Rgs5):
     adipose tissue  cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  no phenotypic analysis  normal  tumorigenesis 

    RGS5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RGS5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-AlphaQ Signaling
    		G-AlphaQ Signaling1.00
    		G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    		Calcium Regulation in the Cardiac Cell1.00
    		Myometrial Relaxation and Contraction Pathways0.43
    3Activation of cAMP-Dependent PKA
    		cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS5
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    2 BioSystems Pathways for RGS5 
        Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for RGS5 (O155393 ENSP000003193084) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=2 STRING: ENSP00000262493
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    GNAI2P048993, ENSP000003129994I2D: score=2 STRING: ENSP00000312999
    GNAI3P087543, ENSP000003588674I2D: score=2 STRING: ENSP00000358867
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS10471929
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS10471929


    RGS5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGS5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS5
    1 Novoseek chemical compound relationship for RGS5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 28.7 1 16839744 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS5 

    Transcripts
    for RGS5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGS5 gene (5 alternative transcripts): 
    NM_001195303.2  NM_001254748.1  NM_001254749.1  NM_003617.3  NM_025226.1  

    Unigene Clusters for RGS5:

    Regulator of G-protein signaling 5
    Hs.24950  [show with all ESTs], Hs.677623  [show with all ESTs]
    Unigene Representative Sequences: NM_001254749, NR_045630
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469495 ENST00000313961(uc021pdt.1 uc001gcn.3 uc009wvb.3 uc021pdu.1)
    ENST00000367903 ENST00000530507 ENST00000527988 ENST00000525894 ENST00000531476


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    hsa-miR-124* hsa-miR-320a hsa-miR-875-3p hsa-miR-4307 hsa-miR-4263 hsa-miR-628-3p hsa-miR-4260 hsa-miR-1257
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    BC032239.1 NR_045630.1 

    24/38 DOTS entries (see all 38):

    DT.454413  DT.87078932  DT.100697498  DT.118879  DT.95170879  DT.95263781  DT.100697493  DT.92407095 
    DT.75101419  DT.121444527  DT.99995326  DT.121444614  DT.121444507  DT.100009872  DT.95258230  DT.100751710 
    DT.100864129  DT.101958879  DT.121444480  DT.121444574  DT.97801608  DT.100683459  DT.100697484  DT.100860237 

    24/888 AceView cDNA sequences (see all 888):

    AU130764 CR617436 AI201552 BE890175 AI085591 AA026803 D58272 AA486366 
    AA319464 CD677590 AW300081 CA397513 BE327838 AA258304 AU126410 N81149 
    BX484691 BQ432359 CB963541 D57507 AI273948 NM_003617 BQ576031 BU508112 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RGS5 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
    SP1:                    -     -                                   -     -                     
    SP2:                    -     -                                         -                     
    SP3:                    -     -                                                               
    SP4:                          -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RGS5

    Expression
    for RGS5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAGAGACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RGS5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    Lateral Plate MesodermSplanchnic MesodermPericytesPericytes
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    PlacentaChorioallantoic PlacentaExtraembryonic AngioblastsEndothelium
    BoneMandibular ProcessBone
    HeartDorsal AortaHeart
    HeartHeart TubeHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Paraxial mesoderm-derived smooth muscle cells (Generation of human ...)
    Primitive gut tube-like cells (A scalable, suspensi...)

    See RGS5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS5

    SOURCE GeneReport for Unigene clusters: Hs.24950 Hs.677623
        SABiosciences Custom PCR Arrays for RGS5
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    In Situ
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    Orthologs
    for RGS5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RGS5 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RGS51 regulator of G-protein signaling 5 80.29(n)
    84.53(a)    		   769998  XM_001233313.2  XP_001233314.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RGS56
    		 --
    		 68(a)
    		 1 ↔ 1
    		 4(71221035-71230191)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj30h052 wufj30h05 76.81(n)   335630  BC054594.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rgs-76
    rgs-46
    		 Regulator of G-protein signaling rgs-7
    Regulator of G protein Signaling family member (rg...
    		 7(a)
    19(a)
    		 1 ↔ many
    possible ortholog
    		 X(3542545-3557581)
    II(12667632-12671556)


    ENSEMBL Gene Tree for RGS5 (if available)
    TreeFam Gene Tree for RGS5 (if available) 

    Paralogs
    for RGS5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS5 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS162  RGS202  RGS172  
    RGS12  RGS182  RGS42  RGS132  
    18/20 SIMAP similar genes for RGS5 using alignment to 3 protein entries:     RGS5_HUMAN (see all proteins) (see all similar genes):
    RGS4    RGS8    RGS21    RGS3    RGS17    RGS16
    RGS18    RGS1    RGS13    RGS6    RGS20    RGS10
    RGS19    RGS2    RGS9    RGS7    AXIN1    RGS11

    RGS5 for paralogs           About GeneDecksing



    Genomic Variants
    for RGS5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1920 NCBI SNPs in RGS5 are shown (see all 1920)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs771246361,2
    		F,--134357008(+) GTGAGC/GACCAA 4 -- ds50011Minor allele frequency- G:0.03WA 118
    rs730207871,2
    		C,--134357050(+) TGGCAT/ACTGGA 4 -- ds50012Minor allele frequency- A:0.03WA 120
    rs792397251,2
    		--134358439(+) CATGTC/ACAAAA 4 -- ut311Minor allele frequency- A:0.01EA 120
    rs562121371,2
    		C,F,--134358975(+) ATTTAT/CTTGTT 4 -- ut311Minor allele frequency- C:0.06NA 120
    rs726939661,2
    		C,--134359213(+) GGGGTA/GTGGAG 4 -- ut310--------
    rs413757481,2
    		C,F,H,--134359387(+) TGAAGG/TCTATT 4 -- ut3113Minor allele frequency- T:0.03NS EA NA WA 1342
    rs777270531,2
    		--134359562(+) AATCTT/CAGGTT 4 -- ut311Minor allele frequency- C:0.01WA 118
    rs802174751,2
    		C,F,--134359799(+) TACACA/GTGTTT 4 -- ut311Minor allele frequency- G:0.02EA 120
    rs755936941,2
    		C,F,--134360112(+) AGATAT/CATGTA 4 -- ut311Minor allele frequency- C:0.06WA 118
    rs168498021,2
    		C,F,H,--134360516(+) AAAGGG/ATTGGC 4 -- ut3110Minor allele frequency- A:0.04NA EA NS 874

    HapMap Linkage Disequilibrium report for RGS5 (163080911 - 163187426 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RGS5: --

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    Disorders / Diseases
    for RGS5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGS5 for disorders           About GeneDecksing

    OMIM gene information: 603276   
    OMIM disorders: 145500  
    18 diseases for RGS5:    About MalaCards
    blood pressure regulation qtl    benign paroxysmal positional nystagmus    hypoxia    yaws
    essential hypertension    renal cell carcinoma    squamous cell carcinoma    nystagmus
    bipolar disorder    lung cancer    pulmonary disease    hypertension
    atherosclerosis    fibrosis    carcinoma    esophagitis
    schizophrenia    adenocarcinoma

    Human Genome Epidemiology (HuGE) Navigator: RGS5 (11 documents)

    Export disorders for RGS5 gene to outside databases

    Publications
    for RGS5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS5 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with RGS5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene. (PubMed id 9747037)1, 2, 3, 9 Seki N.... Hori T. (1998)
    2. Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. (PubMed id 15670159)1, 2, 9 Liang Y.... Woodwrad D.F. (2005)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. (PubMed id 10471929)1, 2 Cismowski M.J.... Duzic E. (1999)
    6. RGS5, a hypoxia-inducible apoptotic stimulator in end othelial cells. (PubMed id 19564336)1, 9 Jin Y....Li J. (2009)
    7. Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5). (PubMed id 17762159)1, 9 Yang Z....Greenwood M.T. (2007)
    8. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PubMed id 18262772)1, 9 Campbell D.B....Sullivan P.F. (2008)
    9. Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-. (PubMed id 17100651)1, 9 Rhee K.H....Hwang K.Y. (2006)
    10. A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media. (PubMed id 11009569)1, 9 Adams L.D....Schwartz S.M. (2000)

    External Searches for RGS5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing RGS5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8490 HGNC: 10001 AceView: RGS5 Ensembl:ENSG00000143248 euGenes: HUgn8490
    ECgene: RGS5 H-InvDB: RGS5

    Other Databases showing RGS5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RGS5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RGS5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RGS5 gene:
    Search GeneIP for patents involving RGS5

    GeneCards and IP:
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