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Aliases for RGS5 Gene

Aliases for RGS5 Gene

  • Regulator Of G-Protein Signaling 5 2 3
  • Regulator Of G-Protein Signalling 5 2
  • MSTP032 3
  • MSTP092 3
  • MSTP106 3
  • MSTP129 3
  • MST092 3
  • MST106 3
  • MST129 3

External Ids for RGS5 Gene

Previous GeneCards Identifiers for RGS5 Gene

  • GC01M160750
  • GC01M158766
  • GC01M159776
  • GC01M160299
  • GC01M159843
  • GC01M161378
  • GC01M134357

Summaries for RGS5 Gene

Entrez Gene Summary for RGS5 Gene

  • This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for RGS5 Gene

RGS5 (Regulator Of G-Protein Signaling 5) is a Protein Coding gene. Diseases associated with RGS5 include benign paroxysmal positional nystagmus and hypoxia. Among its related pathways are Activation of cAMP-Dependent PKA and G-AlphaQ Signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS5 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).

Gene Wiki entry for RGS5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS5 Gene

Genomics for RGS5 Gene

Regulatory Elements for RGS5 Gene

Genomic Location for RGS5 Gene

163,111,121 bp from pter
163,321,791 bp from pter
210,671 bases
Minus strand

Genomic View for RGS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS5 Gene

Proteins for RGS5 Gene

  • Protein details for RGS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 5
    Protein Accession:
    Secondary Accessions:
    • E9PMP5
    • Q53XA9
    • Q599J0

    Protein attributes for RGS5 Gene

    181 amino acids
    Molecular mass:
    20946 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS5 Gene

    Alternative splice isoforms for RGS5 Gene


neXtProt entry for RGS5 Gene

Proteomics data for RGS5 Gene at MOPED

Post-translational modifications for RGS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS5 Gene

Domains for RGS5 Gene

Gene Families for RGS5 Gene

  • RGS :Regulators of G-protein signaling

Protein Domains for RGS5 Gene

Suggested Antigen Peptide Sequences for RGS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O15539
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS5: view

Function for RGS5 Gene

Molecular function for RGS5 Gene

GENATLAS Biochemistry: negative regulator of G protein signaling 5,functioning as GTPase activating protein for G protein alpha i and q subunits,abundantly expressed in heart,lung,skeletal muscle,small intestine,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).

Gene Ontology (GO) - Molecular Function for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RGS5: view
genes like me logo Genes that share phenotypes with RGS5: view

Animal Models for RGS5 Gene

MGI Knock Outs for RGS5:

Animal Model Products

CRISPR Products

miRNA for RGS5 Gene

miRTarBase miRNAs that target RGS5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RGS5 Gene

Localization for RGS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS5 Gene

Isoform 1: Cytoplasm. Membrane.
Isoform 2: Cytoplasm.

Subcellular locations from

Jensen Localization Image for RGS5 Gene COMPARTMENTS Subcellular localization image for RGS5 gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS5: view

Pathways for RGS5 Gene

genes like me logo Genes that share pathways with RGS5: view

Pathways by source for RGS5 Gene

Gene Ontology (GO) - Biological Process for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10471929
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity TAS 10471929
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway --
genes like me logo Genes that share ontologies with RGS5: view

Compounds for RGS5 Gene

(1) Novoseek inferred chemical compound relationships for RGS5 Gene

Compound -log(P) Hits PubMed IDs
gtp 28.7 1
genes like me logo Genes that share compounds with RGS5: view

Transcripts for RGS5 Gene

Unigene Clusters for RGS5 Gene

Regulator of G-protein signaling 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP6: - - - - - - -

Relevant External Links for RGS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS5 Gene

mRNA expression in normal human tissues for RGS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS5 Gene

This gene is overexpressed in Artery - Tibial (13.7) and Artery - Aorta (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGS5 Gene

SOURCE GeneReport for Unigene cluster for RGS5 Gene Hs.24950

genes like me logo Genes that share expressions with RGS5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RGS5 Gene

Orthologs for RGS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS5 35
  • 99.63 (n)
  • 98.9 (a)
RGS5 36
  • 99 (a)
(Bos Taurus)
Mammalia RGS5 35
  • 91.9 (n)
  • 92.27 (a)
RGS5 36
  • 92 (a)
(Canis familiaris)
Mammalia RGS5 35
  • 94.11 (n)
  • 95.03 (a)
RGS5 36
  • 95 (a)
(Mus musculus)
Mammalia Rgs5 35
  • 89.69 (n)
  • 90.06 (a)
Rgs5 16
Rgs5 36
  • 90 (a)
(Monodelphis domestica)
Mammalia RGS5 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia RGS5 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Rgs5 35
  • 88.7 (n)
  • 90 (a)
(Gallus gallus)
Aves RGS5 35
  • 80.29 (n)
  • 84.53 (a)
RGS5 36
  • 85 (a)
(Anolis carolinensis)
Reptilia RGS5 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs5 35
  • 74.22 (n)
  • 80.11 (a)
(Danio rerio)
Actinopterygii rgs5a 35
  • 71.09 (n)
  • 71.27 (a)
rgs5a 36
  • 71 (a)
wufj30h05 35
Species with no ortholog for RGS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS5 Gene

Gene Tree for RGS5 (if available)
Gene Tree for RGS5 (if available)

Paralogs for RGS5 Gene

Paralogs for RGS5 Gene

Selected SIMAP similar genes for RGS5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGS5: view

Variants for RGS5 Gene

Sequence variations from dbSNP and Humsavar for RGS5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3413 -- 163,259,636(+) AAAGC(C/T)GGAAG intron-variant
rs15049 -- 163,147,088(-) CAGAC(A/C)CAATC utr-variant-3-prime
rs937925 -- 163,258,361(-) TTTCT(A/G)TTTAC intron-variant
rs951146 -- 163,286,397(-) TCTAT(A/T)CATAT intron-variant
rs952089 -- 163,318,876(+) GCATT(A/G/T)ACAGA intron-variant

Relevant External Links for RGS5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RGS5 Gene

Disorders for RGS5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RGS5 Gene including...

Search for RGS5 Gene in MalaCards »

(1) OMIM Diseases for RGS5 Gene (603276)

(1) University of Copenhagen DISEASES for RGS5 Gene

Relevant External Links for RGS5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RGS5: view

No data available for UniProtKB/Swiss-Prot for RGS5 Gene

Publications for RGS5 Gene

  1. Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene. (PMID: 9747037) Seki N. … Hori T. (J. Hum. Genet. 1998) 2 3 4 23
  2. Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. (PMID: 15670159) Liang Y. … Woodwrad D.F. (FEBS J. 2005) 3 4 23
  3. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 23 48
  4. Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5). (PMID: 17762159) Yang Z. … Greenwood M.T. (Cell. Physiol. Biochem. 2007) 3 23
  5. Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-. (PMID: 17100651) Rhee K.H. … Hwang K.Y. (Protein Pept. Lett. 2006) 3 23

Products for RGS5 Gene

Sources for RGS5 Gene

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