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Aliases for RGS5 Gene

Aliases for RGS5 Gene

  • Regulator Of G Protein Signaling 5 2 3
  • Regulator Of G-Protein Signaling 5 2 3 5
  • Regulator Of G-Protein Signalling 5 2
  • MSTP032 3
  • MSTP092 3
  • MSTP106 3
  • MSTP129 3
  • MST092 3
  • MST106 3
  • MST129 3

External Ids for RGS5 Gene

Previous GeneCards Identifiers for RGS5 Gene

  • GC01M160750
  • GC01M158766
  • GC01M159776
  • GC01M160299
  • GC01M159843
  • GC01M161378
  • GC01M134357

Summaries for RGS5 Gene

Entrez Gene Summary for RGS5 Gene

  • This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for RGS5 Gene

RGS5 (Regulator Of G Protein Signaling 5) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS4.

UniProtKB/Swiss-Prot for RGS5 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).

Gene Wiki entry for RGS5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS5 Gene

Genomics for RGS5 Gene

Regulatory Elements for RGS5 Gene

Enhancers for RGS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G163174 0.9 Ensembl ENCODE 10.4 +146.8 146782 0.4 CTCF ZNF654 TRIM22 SIN3A BMI1 REST ZNF2 RAD21 SMARCA4 SMC3 RGS4 RGS5 LOC101928404 LOC100113374
GH01G163195 0.8 ENCODE 10.9 +125.3 125302 1.7 HDAC1 JUN ZMYM3 RAD21 FOSL1 CCNT2 GATA2 NFE2 FOS MAFK LOC101928404 RGS5 NUF2 ENSG00000232995 LOC100113374
GH01G163128 0.5 FANTOM5 4.3 +193.1 193148 0.1 ZNF316 MAFG EMSY MAFK LOC101928404 RGS4 RGS5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGS5 on UCSC Golden Path with GeneCards custom track

Promoters for RGS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014966 -206 2201 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3

Genomic Location for RGS5 Gene

Chromosome:
1
Start:
163,111,121 bp from pter
End:
163,321,791 bp from pter
Size:
210,671 bases
Orientation:
Minus strand

Genomic View for RGS5 Gene

Genes around RGS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS5 Gene

Proteins for RGS5 Gene

  • Protein details for RGS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15539-RGS5_HUMAN
    Recommended name:
    Regulator of G-protein signaling 5
    Protein Accession:
    O15539
    Secondary Accessions:
    • E9PMP5
    • Q53XA9
    • Q599J0

    Protein attributes for RGS5 Gene

    Size:
    181 amino acids
    Molecular mass:
    20946 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS5 Gene

    Alternative splice isoforms for RGS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS5 Gene

Post-translational modifications for RGS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS5 Gene

Domains & Families for RGS5 Gene

Gene Families for RGS5 Gene

Protein Domains for RGS5 Gene

Suggested Antigen Peptide Sequences for RGS5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS5: view

No data available for UniProtKB/Swiss-Prot for RGS5 Gene

Function for RGS5 Gene

Molecular function for RGS5 Gene

GENATLAS Biochemistry:
negative regulator of G protein signaling 5,functioning as GTPase activating protein for G protein alpha i and q subunits,abundantly expressed in heart,lung,skeletal muscle,small intestine,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).

Gene Ontology (GO) - Molecular Function for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 10471929
genes like me logo Genes that share ontologies with RGS5: view
genes like me logo Genes that share phenotypes with RGS5: view

Animal Models for RGS5 Gene

MGI Knock Outs for RGS5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS5 Gene

Localization for RGS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS5 Gene

Isoform 1: Cytoplasm. Membrane.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS5 gene
Compartment Confidence
cytosol 5
plasma membrane 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RGS5: view

Pathways & Interactions for RGS5 Gene

genes like me logo Genes that share pathways with RGS5: view

Pathways by source for RGS5 Gene

Gene Ontology (GO) - Biological Process for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10471929
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS5: view

No data available for SIGNOR curated interactions for RGS5 Gene

Drugs & Compounds for RGS5 Gene

(4) Drugs for RGS5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2020
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1856
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1123
leucovorin Approved Nutra 3235,1128

(1) Additional Compounds for RGS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS5: view

Transcripts for RGS5 Gene

Unigene Clusters for RGS5 Gene

Regulator of G-protein signaling 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: - - - - - - -

Relevant External Links for RGS5 Gene

GeneLoc Exon Structure for
RGS5
ECgene alternative splicing isoforms for
RGS5

Expression for RGS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS5 Gene

mRNA differential expression in normal tissues according to GTEx for RGS5 Gene

This gene is overexpressed in Artery - Tibial (x13.7) and Artery - Aorta (x8.3).

Protein differential expression in normal tissues from HIPED for RGS5 Gene

This gene is overexpressed in Lung (52.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS5 Gene



Protein tissue co-expression partners for RGS5 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS5 Gene:

RGS5

SOURCE GeneReport for Unigene cluster for RGS5 Gene:

Hs.24950

Evidence on tissue expression from TISSUES for RGS5 Gene

  • Nervous system(4.9)
  • Eye(4.4)
  • Liver(4.3)
  • Heart(3.5)
  • Muscle(3.1)
  • Pancreas(2.6)
  • Adrenal gland(2.3)
  • Gall bladder(2.2)
  • Lung(2.2)
  • Stomach(2.2)
  • Thyroid gland(2.2)
  • Kidney(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with RGS5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS5 Gene

Orthologs for RGS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS5 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia RGS5 34 35
  • 94.11 (n)
cow
(Bos Taurus)
Mammalia RGS5 34 35
  • 91.9 (n)
mouse
(Mus musculus)
Mammalia Rgs5 34 16 35
  • 89.69 (n)
rat
(Rattus norvegicus)
Mammalia Rgs5 34
  • 88.7 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS5 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS5 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS5 34 35
  • 80.29 (n)
lizard
(Anolis carolinensis)
Reptilia RGS5 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs5 34
  • 74.22 (n)
zebrafish
(Danio rerio)
Actinopterygii rgs5a 34 35
  • 71.09 (n)
wufj30h05 34
Species where no ortholog for RGS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS5 Gene

ENSEMBL:
Gene Tree for RGS5 (if available)
TreeFam:
Gene Tree for RGS5 (if available)

Paralogs for RGS5 Gene

Paralogs for RGS5 Gene

(20) SIMAP similar genes for RGS5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGS5: view

Variants for RGS5 Gene

Sequence variations from dbSNP and Humsavar for RGS5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000008497 -- 163,256,173(+) ATTGT(C/T)CCTGT intron-variant
rs1000018021 -- 163,170,025(+) TTTTA(A/T)AACTA intron-variant
rs1000032625 -- 163,184,705(+) AATCA(A/G)ACAGA intron-variant
rs1000037315 -- 163,273,666(+) ATATA(C/G)GACCA intron-variant
rs1000048839 -- 163,307,385(+) AATTT(G/T)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS5 Gene

Variant ID Type Subtype PubMed ID
esv3353974 CNV insertion 20981092
esv3890704 CNV loss 25118596
nsv1137820 CNV deletion 24896259
nsv946476 CNV duplication 23825009

Variation tolerance for RGS5 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS5 Gene

Disorders for RGS5 Gene

Relevant External Links for RGS5

Genetic Association Database (GAD)
RGS5
Human Genome Epidemiology (HuGE) Navigator
RGS5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS5

No disorders were found for RGS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS5 Gene

Publications for RGS5 Gene

  1. Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene. (PMID: 9747037) Seki N. … Hori T. (J. Hum. Genet. 1998) 2 3 4 22 64
  2. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 22 46 64
  3. Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. (PMID: 15670159) Liang Y. … Woodwrad D.F. (FEBS J. 2005) 3 4 22 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for RGS5 Gene

Sources for RGS5 Gene

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