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Aliases for RGS5 Gene

Aliases for RGS5 Gene

  • Regulator Of G-Protein Signaling 5 5 2 3
  • Regulator Of G-Protein Signalling 5 2
  • MSTP032 3
  • MSTP092 3
  • MSTP106 3
  • MSTP129 3
  • MST092 3
  • MST106 3
  • MST129 3

External Ids for RGS5 Gene

Previous GeneCards Identifiers for RGS5 Gene

  • GC01M160750
  • GC01M158766
  • GC01M159776
  • GC01M160299
  • GC01M159843
  • GC01M161378
  • GC01M134357

Summaries for RGS5 Gene

Entrez Gene Summary for RGS5 Gene

  • This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for RGS5 Gene

RGS5 (Regulator Of G-Protein Signaling 5) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS5 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).

Gene Wiki entry for RGS5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS5 Gene

Genomics for RGS5 Gene

Regulatory Elements for RGS5 Gene

Enhancers for RGS5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGS5 on UCSC Golden Path with GeneCards custom track

Promoters for RGS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGS5 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS5 Gene

163,111,121 bp from pter
163,321,791 bp from pter
210,671 bases
Minus strand

Genomic View for RGS5 Gene

Genes around RGS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS5 Gene

Proteins for RGS5 Gene

  • Protein details for RGS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 5
    Protein Accession:
    Secondary Accessions:
    • E9PMP5
    • Q53XA9
    • Q599J0

    Protein attributes for RGS5 Gene

    181 amino acids
    Molecular mass:
    20946 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS5 Gene

    Alternative splice isoforms for RGS5 Gene


neXtProt entry for RGS5 Gene

Proteomics data for RGS5 Gene at MOPED

Post-translational modifications for RGS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS5 Gene

Domains & Families for RGS5 Gene

Gene Families for RGS5 Gene

Protein Domains for RGS5 Gene

Suggested Antigen Peptide Sequences for RGS5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RGS domain.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS5: view

Function for RGS5 Gene

Molecular function for RGS5 Gene

GENATLAS Biochemistry:
negative regulator of G protein signaling 5,functioning as GTPase activating protein for G protein alpha i and q subunits,abundantly expressed in heart,lung,skeletal muscle,small intestine,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).
genes like me logo Genes that share phenotypes with RGS5: view

Animal Models for RGS5 Gene

MGI Knock Outs for RGS5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS5 Gene

Localization for RGS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS5 Gene

Isoform 1: Cytoplasm. Membrane.
Isoform 2: Cytoplasm.

Subcellular locations from

Jensen Localization Image for RGS5 Gene COMPARTMENTS Subcellular localization image for RGS5 gene
Compartment Confidence
cytosol 4
plasma membrane 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RGS5: view

Pathways & Interactions for RGS5 Gene

genes like me logo Genes that share pathways with RGS5: view

Gene Ontology (GO) - Biological Process for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity TAS 10471929
genes like me logo Genes that share ontologies with RGS5: view

No data available for SIGNOR curated interactions for RGS5 Gene

Drugs & Compounds for RGS5 Gene

(4) Drugs for RGS5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 1910
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1697
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1055
leucovorin Approved Pharma 1029

(1) Additional Compounds for RGS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS5: view

Transcripts for RGS5 Gene

Unigene Clusters for RGS5 Gene

Regulator of G-protein signaling 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP6: - - - - - - -

Relevant External Links for RGS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS5 Gene

mRNA expression in normal human tissues for RGS5 Gene

mRNA differential expression in normal tissues according to GTEx for RGS5 Gene

This gene is overexpressed in Artery - Tibial (x13.7) and Artery - Aorta (x8.3).

Protein differential expression in normal tissues from HIPED for RGS5 Gene

This gene is overexpressed in Lung (52.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS5 Gene

SOURCE GeneReport for Unigene cluster for RGS5 Gene Hs.24950

genes like me logo Genes that share expression patterns with RGS5: view

Protein tissue co-expression partners for RGS5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RGS5 Gene

Orthologs for RGS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RGS5 35
  • 91.9 (n)
  • 92.27 (a)
RGS5 36
  • 92 (a)
(Canis familiaris)
Mammalia RGS5 35
  • 94.11 (n)
  • 95.03 (a)
RGS5 36
  • 95 (a)
(Mus musculus)
Mammalia Rgs5 35
  • 89.69 (n)
  • 90.06 (a)
Rgs5 16
Rgs5 36
  • 90 (a)
(Pan troglodytes)
Mammalia RGS5 35
  • 99.63 (n)
  • 98.9 (a)
RGS5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rgs5 35
  • 88.7 (n)
  • 90 (a)
(Monodelphis domestica)
Mammalia RGS5 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia RGS5 36
  • 64 (a)
(Gallus gallus)
Aves RGS5 35
  • 80.29 (n)
  • 84.53 (a)
RGS5 36
  • 85 (a)
(Anolis carolinensis)
Reptilia RGS5 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs5 35
  • 74.22 (n)
  • 80.11 (a)
(Danio rerio)
Actinopterygii rgs5a 35
  • 71.09 (n)
  • 71.27 (a)
wufj30h05 35
rgs5a 36
  • 71 (a)
Species with no ortholog for RGS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS5 Gene

Gene Tree for RGS5 (if available)
Gene Tree for RGS5 (if available)

Paralogs for RGS5 Gene

Paralogs for RGS5 Gene

(20) SIMAP similar genes for RGS5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGS5: view

Variants for RGS5 Gene

Sequence variations from dbSNP and Humsavar for RGS5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3413 -- 163,259,636(+) AAAGC(C/T)GGAAG intron-variant
rs15049 -- 163,147,088(-) CAGAC(A/C)CAATC utr-variant-3-prime
rs961352 -- 163,260,445(+) AAAAT(G/T)AGCGC intron-variant
rs976287 -- 163,251,667(-) ATAAC(C/T)ACAGG intron-variant
rs976288 -- 163,251,361(-) AAATT(A/T)TAAAA intron-variant

Variation tolerance for RGS5 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RGS5 Gene

Disorders for RGS5 Gene

Relevant External Links for RGS5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS5 Gene

Publications for RGS5 Gene

  1. Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene. (PMID: 9747037) Seki N. … Hori T. (J. Hum. Genet. 1998) 2 3 4 23 67
  2. RGS5, a hypoxia-inducible apoptotic stimulator in endothelial cells. (PMID: 19564336) Jin Y. … Li J. (J. Biol. Chem. 2009) 3 23
  3. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 23
  4. N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. (PMID: 17220356) Bodenstein J. … Neubig R.R. (Mol. Pharmacol. 2007) 3 23
  5. Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5). (PMID: 17762159) Yang Z. … Greenwood M.T. (Cell. Physiol. Biochem. 2007) 3 23

Products for RGS5 Gene

Sources for RGS5 Gene