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Aliases for RGS4 Gene

Aliases for RGS4 Gene

  • Regulator Of G-Protein Signaling 4 2 3 5
  • Schizophrenia Disorder 9 2 3
  • RGP4 3 4
  • Regulator Of G-Protein Signalling 4 2
  • SCZD9 3

External Ids for RGS4 Gene

Previous HGNC Symbols for RGS4 Gene

  • SCZD9

Previous GeneCards Identifiers for RGS4 Gene

  • GC01P160674
  • GC01P158689
  • GC01P159735
  • GC01P160226
  • GC01P159770
  • GC01P161305
  • GC01P134283

Summaries for RGS4 Gene

Entrez Gene Summary for RGS4 Gene

  • Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS4 Gene

RGS4 (Regulator Of G-Protein Signaling 4) is a Protein Coding gene. Diseases associated with RGS4 include Schizophrenia and Bipolar Disorder. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding. An important paralog of this gene is RGS3.

UniProtKB/Swiss-Prot for RGS4 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

Tocris Summary for RGS4 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand binding causes a receptor conformational change, detaching the G protein and switching it 'on'.

Gene Wiki entry for RGS4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS4 Gene

Genomics for RGS4 Gene

Regulatory Elements for RGS4 Gene

Enhancers for RGS4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F163034 1.3 FANTOM5 Ensembl ENCODE 12 -32.8 -32795 3.1 GTF2F1 TBP JUN RFX5 ZFHX2 ELK1 PRDM10 RCOR1 FOS MAFK RGS4 UAP1 DDR2 ENSG00000227667
GH01F162854 1.4 FANTOM5 Ensembl ENCODE 9.8 -212.1 -212123 4.3 ELF3 ATF1 KLF17 FEZF1 RAD21 SCRT2 FOS ZNF362 ZNF654 ELF1 CCDC190 RGS4 ENSG00000230739
GH01F162982 0.8 FANTOM5 ENCODE 15.7 -84.2 -84158 3.1 JUN CEBPB CEBPG RGS4 ENSG00000227667
GH01F163320 1.2 ENCODE 10 +253.6 253554 3.1 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 ENSG00000272574 NUF2 UAP1 RGS4 LOC101928404 ENSG00000232995 LOC100422212
GH01F162872 1.1 Ensembl ENCODE 9.8 -194.6 -194583 2.2 SOX13 ELF3 CTCF SAP130 ZNF792 RARA YY1 GATA3 RERE SMC3 LOC101928404 RGS4 CCDC190 ENSG00000227667
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGS4 on UCSC Golden Path with GeneCards custom track

Promoters for RGS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000546693 1695 3400 CTCF TEAD4 SIN3A RAD21 RFX5 ZNF316 POLR2A ZNF143 SMC3 MAFK

Genomic Location for RGS4 Gene

Chromosome:
1
Start:
163,068,606 bp from pter
End:
163,076,802 bp from pter
Size:
8,197 bases
Orientation:
Plus strand

Genomic View for RGS4 Gene

Genes around RGS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS4 Gene

Proteins for RGS4 Gene

  • Protein details for RGS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49798-RGS4_HUMAN
    Recommended name:
    Regulator of G-protein signaling 4
    Protein Accession:
    P49798
    Secondary Accessions:
    • A7XA56
    • A7XA58
    • A7XA59
    • A7YVV7
    • B1APZ3

    Protein attributes for RGS4 Gene

    Size:
    205 amino acids
    Molecular mass:
    23256 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RGS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS4 Gene

Post-translational modifications for RGS4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RGS4 (RGS4)

No data available for DME Specific Peptides for RGS4 Gene

Domains & Families for RGS4 Gene

Gene Families for RGS4 Gene

Protein Domains for RGS4 Gene

Graphical View of Domain Structure for InterPro Entry

P49798

UniProtKB/Swiss-Prot:

RGS4_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS4: view

Function for RGS4 Gene

Molecular function for RGS4 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

Gene Ontology (GO) - Molecular Function for RGS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0005096 GTPase activator activity IEA,TAS --
GO:0005516 calmodulin binding TAS 10747990
genes like me logo Genes that share ontologies with RGS4: view
genes like me logo Genes that share phenotypes with RGS4: view

Animal Models for RGS4 Gene

MGI Knock Outs for RGS4:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS4 Gene

Localization for RGS4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS4 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4
extracellular 1
cytoskeleton 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RGS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10791963
GO:0005737 cytoplasm IDA 10791963
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RGS4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGS4 Gene

Pathways & Interactions for RGS4 Gene

genes like me logo Genes that share pathways with RGS4: view

Pathways by source for RGS4 Gene

1 Sino Biological pathway for RGS4 Gene
1 Cell Signaling Technology pathway for RGS4 Gene

Gene Ontology (GO) - Biological Process for RGS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8602223
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10747990
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IEA --
genes like me logo Genes that share ontologies with RGS4: view

No data available for SIGNOR curated interactions for RGS4 Gene

Drugs & Compounds for RGS4 Gene

(23) Drugs for RGS4 Gene - From: PharmGKB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist 395
Perphenazine Approved Pharma Antagonist 94
Quetiapine Approved Pharma Antagonist 0
Risperidone Approved, Investigational Pharma Antagonist SR-2A inhibitor 487
Ziprasidone Approved Pharma Antagonist 5-HT (serotonin)/dopamine receptor antagonist 145

(12) Additional Compounds for RGS4 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Bromo-cGMP, sodium salt
51116-01-9
CMPD101
865608-11-3
Gallein
2103-64-2
G-Protein antagonist peptide
143675-79-0
Pertussis Toxin
70323-44-3

(5) Tocris Compounds for RGS4 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
CMPD101 Potent and selective GRK2/3 inhibitor 865608-11-3
Gallein Inhibitor of betagamma signaling 2103-64-2
G-Protein antagonist peptide Inhibits G protein activation by GPCRs 143675-79-0
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt 70323-44-3

(4) ApexBio Compounds for RGS4 Gene

Compound Action Cas Number
CCG 2046 Inhibitor of RGS4 regulator 13017-69-1
CCG 50014 RGS4 Inhibitor,potent and selective 883050-24-6
CCG-63802 RGS protein inhibitor 620112-78-9
CCG-63808 Reversible RGS inhibitor 620113-73-7
genes like me logo Genes that share compounds with RGS4: view

Transcripts for RGS4 Gene

Unigene Clusters for RGS4 Gene

Regulator of G-protein signaling 4:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5:
SP6: - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - -

Relevant External Links for RGS4 Gene

GeneLoc Exon Structure for
RGS4
ECgene alternative splicing isoforms for
RGS4

Expression for RGS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x12.4), Brain - Anterior cingulate cortex (BA24) (x10.8), and Brain - Cortex (x9.8).

Protein differential expression in normal tissues from HIPED for RGS4 Gene

This gene is overexpressed in Serum (41.2) and Bone marrow mesenchymal stem cell (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS4 Gene



Protein tissue co-expression partners for RGS4 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS4 Gene:

RGS4

SOURCE GeneReport for Unigene cluster for RGS4 Gene:

Hs.386726

mRNA Expression by UniProt/SwissProt for RGS4 Gene:

P49798-RGS4_HUMAN
Tissue specificity: Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.
genes like me logo Genes that share expression patterns with RGS4: view

Orthologs for RGS4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS4 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia RGS4 34 35
  • 92.85 (n)
dog
(Canis familiaris)
Mammalia RGS4 34 35
  • 92.36 (n)
rat
(Rattus norvegicus)
Mammalia Rgs4 34
  • 90.24 (n)
mouse
(Mus musculus)
Mammalia Rgs4 34 16 35
  • 89.43 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS4 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RGS4 34 35
  • 75.49 (n)
lizard
(Anolis carolinensis)
Reptilia RGS4 35
  • 5 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs4 34
  • 68.28 (n)
MGC76188 34
African clawed frog
(Xenopus laevis)
Amphibia rgs4-A 34
zebrafish
(Danio rerio)
Actinopterygii rgs4 34 34 35
  • 59.11 (n)
Species where no ortholog for RGS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS4 Gene

ENSEMBL:
Gene Tree for RGS4 (if available)
TreeFam:
Gene Tree for RGS4 (if available)

Paralogs for RGS4 Gene

Paralogs for RGS4 Gene

(19) SIMAP similar genes for RGS4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGS4: view

Variants for RGS4 Gene

Sequence variations from dbSNP and Humsavar for RGS4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10759 -- 163,076,561(-) TTCAG(A/C)GTGAC utr-variant-3-prime
rs10799897 -- 163,073,298(+) AGATT(A/G)GGGTT intron-variant
rs10917671 -- 163,069,063(+) TACAG(A/G)CATAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10917672 -- 163,070,022(+) ACTCT(C/T)TATGT intron-variant, upstream-variant-2KB
rs111231749 -- 163,072,010(+) TTTGC(C/T)GCTAC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RGS4 Gene

Variant ID Type Subtype PubMed ID
nsv3332 CNV insertion 18451855

Variation tolerance for RGS4 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS4 Gene

Human Gene Mutation Database (HGMD)
RGS4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS4 Gene

Disorders for RGS4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RGS4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
bipolar disorder
  • bipolar depression
psychotic disorder
  • mental or behavioural disorder
- elite association - COSMIC cancer census association via MalaCards
Search RGS4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RGS4_HUMAN
  • Schizophrenia 9 (SCZD9) [MIM:604906]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:12023979, ECO:0000269 PubMed:14755443}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for RGS4

Genetic Association Database (GAD)
RGS4
Human Genome Epidemiology (HuGE) Navigator
RGS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS4
genes like me logo Genes that share disorders with RGS4: view

No data available for Genatlas for RGS4 Gene

Publications for RGS4 Gene

  1. Confirming RGS4 as a susceptibility gene for schizophrenia. (PMID: 14755443) Morris D.W. … Corvin A.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 4 22 46 64
  2. Association and linkage analyses of RGS4 polymorphisms in schizophrenia. (PMID: 12023979) Chowdari K.V. … Nimgaonkar V.L. (Hum. Mol. Genet. 2002) 3 4 22 46 64
  3. Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample. (PMID: 19937977) RActhelyi J.M. … Bitter I. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 22 46 64
  4. Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia. (PMID: 17588543) Campbell D.B. … Sullivan P.F. (Biol. Psychiatry 2008) 3 22 46 64
  5. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 22 46 64

Products for RGS4 Gene

  • Addgene plasmids for RGS4

Sources for RGS4 Gene

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