Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGS4 Gene

protein-coding GIFtS: 59
GCID: GC01P163038

regulator of G-protein signaling 4

(Previous names: regulator of G-protein signalling 4, schizophrenia disorder...)
(Previous symbol: SCZD9)

Explore 23 diseases affiliated with
RGS4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 4¹ ²
SCZD9¹ ²
Schizophrenia Disorder 9¹ ²
RGP4² ³
Regulator Of G-Protein Signalling 4¹

External Ids:	HGNC: 10000¹	Entrez Gene: 5999²	Ensembl: ENSG00000117152⁷	OMIM: 602516⁵	UniProtKB: P49798³

Export aliases for RGS4 gene to outside databases

Previous GC identifers: GC01P160674 GC01P158689 GC01P159735 GC01P160226 GC01P159770 GC01P161305 GC01P134283

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS4:

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins

(GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of

the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of

G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the

RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This

protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the

cytoplasm. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein.

Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein

summary for RGS4:

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein

contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding

results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of

second messenger signalling cascades. Regulators of G protein signalling, such as RGS4, promote GTP

hydrolysis by the alpha subunit in order to inactivate the G protein.

Gene Wiki entry for RGS4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGS4 gene promoter:
CREB SRF (504 AA) deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS4 promoter sequence

Search SABiosciences Chromatin IP Primers for RGS4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3

RGS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P163038: view genomic region (about GC identifiers)

Start:	163,038,396 bp from pter	End:	163,046,592 bp from pter
Size:	8,197 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798 (See protein sequence)

Recommended Name: Regulator of G-protein signaling 4

Size: 205 amino acids; 23256 Da

Secondary accessions: A7XA56 A7XA58 A7XA59 A7YVV7 B1APZ3

Alternative splicing: 5 isoforms: P49798-1 P49798-2 P49798-3 P49798-4 P49798-5

Explore the universe of human proteins at neXtProt for RGS4: NX_P49798

Post-translational modifications:

Palmitoylated on Cys-2 and/or Cys-12¹

Phosphorylated by cyclic GMP-dependent protein kinase (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49798

RGS4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001095915.1 NP_001106851.1 NP_001106852.1 NP_005604.1

ENSEMBL proteins:

ENSP00000397181 ENSP00000356885 ENSP00000436106 ENSP00000433261 ENSP00000356884

ENSP00000356882 ENSP00000432194

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RGS4 OriGene Protein Over-expression Lysate (see all 3): RGS4 OriGene Custom Protein Services for RGS4
	GenScript Custom Purified and Recombinant Proteins Services for RGS4
	Novus Biologicals RGS4 Proteins Novus Biologicals RGS4 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RGS4
	Uscn Proteins for RGS4

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	IBA	--
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	IBA	--

RGS4 for ontologies About GeneDecksing

RGS4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RGS4
	OriGene Antibodies: RGS4 OriGene Custom Antibody Services for RGS4
	GenScript Custom Superior Antibodies Services for RGS4
	Novus Biologicals RGS4 Antibodies
	Abcam antibodies for RGS4
	Uscn Antibodies for RGS4
	ThermoFisher Antibody for RGS4

Assay Products for RGS4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RGS4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RGS4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGS4 for domains About GeneDecksing

3 InterPro domains/families:

IPR024066 Regulat_G_prot_signal_dom1

IPR000342 Regulat_G_prot_signal

IPR016137 Regulat_G_prot_signal_superfam

Graphical View of Domain Structure for InterPro Entry P49798

ProtoNet protein and cluster: P49798

1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798

Similarity: Contains 1 RGS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein.

Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein

miRNA Products:		OriGene 3'-UTR Clone (see all 4): RGS4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS4
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS4 (see all 29):
		hsa-miR-498 hsa-miR-136 hsa-miR-146b-3p hsa-miR-16-2* hsa-miR-125a-3p hsa-miR-340 hsa-miR-520a-5p hsa-miR-1297

		SwitchGear 3'UTR luciferase reporter plasmid: RGS4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS4 (see all 7) OriGene shRNA RFP: RGS4 OriGene siRNA: RGS4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RGS4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS4 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): RGS4 (NM_001102445)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RGS4
		Search LifeMap BioReagents cell lines for RGS4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IBA	--
GO:0005516	calmodulin binding	TAS	10747990

RGS4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Rgs4^tm1.1Jlr for RGS4
     11 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Rgs4):

adipose tissue	behavior/neurological	endocrine/exocrine gland	growth/size	homeostasis/metabolism
integument	mortality/aging	nervous system	no phenotypic analysis	normal
reproductive system

RGS4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-AlphaQ Signaling

G-AlphaQ Signaling

1.00

G-AlphaI Signaling

0.47

Calcium Regulation in the Cardiac Cell

Calcium Regulation in the Cardiac Cell

1.00

Myometrial Relaxation and Contraction Pathways

0.43

Neuroscience

Neuroscience

1.00

Ca, cAMP and Lipid Signaling

Ca, cAMP and Lipid Signaling

1.00

Activation of cAMP-Dependent PKA

cAMP Pathway

0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS4

	cAMP Pathway
	G-AlphaI Signaling
	G-AlphaQ Signaling

2 Cell Signaling Technology (CST) Pathways for RGS4

	Ca, cAMP and Lipid Signaling
	Neuroscience

2 BioSystems Pathways for RGS4

	Myometrial Relaxation and Contraction Pathways
	Calcium Regulation in the Cardiac Cell

RGS4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RGS4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/140 Interacting proteins for RGS4 (P49798³ ENSP00000397181⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 140)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COPB2	P35606³, ENSP00000329419⁴	I2D: score=1 STRING: ENSP00000329419
GNAO1	P09471³, ENSP00000262493⁴	I2D: score=1 STRING: ENSP00000262493
GNAQ	P50148³, ENSP00000286548⁴	I2D: score=1 STRING: ENSP00000286548
KRIT1	O00522³, ENSP00000344668⁴	I2D: score=1 STRING: ENSP00000344668
GNAI1	P63096³, ENSP00000343027⁴	I2D: score=3 STRING: ENSP00000343027

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000188	inactivation of MAPK activity	TAS	8602223
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	TAS	10747990
GO:0038032	termination of G-protein coupled receptor signaling pathway	IEA	--
GO:0043547	positive regulation of GTPase activity	TAS	10747990

RGS4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RGS4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for RGS4 available from Tocris Bioscience About this table

Compound	Action	CAS #
CCG 2046	Inhibitor of regulator of G-protein signaling 4 (RGS4)	[13017-69-1]
CCG 63802	Inhibitor of regulator of G-protein signaling 4 (RGS4) protein	[620112-78-9]
CCG 50014	Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4)	[883050-24-6]

10/20 Novoseek chemical compound relationships for RGS4 gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	70.1	19	9430692 (3), 9108480 (2), 10387017 (2), 10807934 (2) (see all 13)
phosphatidylinositol-3,4,5-trisphosphate	66.9	3	15324308 (2), 11148035 (1)
damgo	37.7	4	20002516 (2), 11755131 (1), 16377088 (1)
gdp	30.2	1	8774882 (1)
dopamine	28.5	13	16905560 (2), 18815258 (1), 16565965 (1), 16082709 (1) (see all 6)
quinpirole	23.6	2	17179741 (1), 12603835 (1)
phosphoinositide	13.2	7	16885398 (4), 15383626 (1), 9115254 (1)
cysteine	10	10	12753087 (2), 12642592 (2), 17660054 (1), 11274219 (1) (see all 6)
acetylcholine	7.09	1	12538649 (1)
forskolin	6.46	1	15369705 (1)

6 PharmGKB related drug/compound annotations for RGS4 gene

Drug/compound	PharmGKB Annotation
antipsychotics	CA
olanzapine	CA
perphenazine	CA
quetiapine	CA
risperidone	CA
ziprasidone	CA

About this table

Search CenterWatch for drugs/clinical trials and news about RGS4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGS4 gene (4 alternative transcripts):

NM_001102445.2 NM_001113380.1 NM_001113381.1 NM_005613.5

Unigene Cluster for RGS4:

Regulator of G-protein signaling 4

Hs.386726 [show with all ESTs]

Unigene Representative Sequence: NM_001102445

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000421743(uc001gcl.4) ENST00000527393 ENST00000367909(uc009wuy.3 uc009wuz.3 uc009wva.3)

ENST00000531057 ENST00000527809 ENST00000367908 ENST00000491263 ENST00000533019

ENST00000367906 ENST00000528938

miRNA Products:		OriGene 3'-UTR Clone (see all 4): RGS4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS4
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS4 (see all 29):
		hsa-miR-498 hsa-miR-136 hsa-miR-146b-3p hsa-miR-16-2* hsa-miR-125a-3p hsa-miR-340 hsa-miR-520a-5p hsa-miR-1297

		SwitchGear 3'UTR luciferase reporter plasmid: RGS4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS4 (see all 7) OriGene shRNA RFP: RGS4 OriGene siRNA: RGS4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS4 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): RGS4 (NM_001102445)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RGS4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS4

Additional cDNA sequence:

AF493928.1 AK093959.1 AK295540.1 AK296240.1 AK300832.1 AK312250.1 AL137433.1 BC000737.1

BC051869.1 BT007025.1 DQ346662.1 DQ346663.1 DQ346664.1 EF054877.1 U27768.1

13 DOTS entries:

DT.100790591 DT.100044434 DT.100790597 DT.441476 DT.100790592 DT.100790594 DT.100790593 DT.121437776

DT.121437810 DT.100044436 DT.121437755 DT.121437806 DT.121437756

24/204 AceView cDNA sequences (see all 204):

CN484299 CN481874 BP336664 AA776229 CD679102 BM467809 BE889095 BM930153

BP342248 AW449093 BU507128 BM458112 CD671309 BM684773 BU072480 BP337084

BP335473 AF493928 BX393519 AA669905 CB160610 CN482582 BU149136 BU743084

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RGS4 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	·	9g
SP1:					-										-		-
SP2:															-		-
SP3:															-		-
SP4:													-		-		-
SP5:

ECgene alternative splicing isoforms for RGS4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGS4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTTGATAG

About this image

RGS4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Head Mesenchyme

Frontonasal Process

Head Mesenchyme

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)

Name

Category

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Midbrain dopaminergic-like neurons (Generation of midbra...)

DKK1-induced cells (Derivation of cardio...)

Mesendoderm (Derivation and sorti...)

See RGS4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGS4

SOURCE GeneReport for Unigene cluster: Hs.386726

UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798

Tissue specificity: Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and

visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not

expressed in the cerebellum

SABiosciences Expression via Pathway-Focused PCR Arrays including RGS4:

Parkinson's Disease in human mouse rat

Huntington's Disease in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RGS4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RGS4 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RGS4¹	regulator of G-protein signaling 4	75.65(n) 76.96(a)		378901 NM_204385.1 NP_989716.1
African clawed frog (Xenopus laevis)	Amphibia	rgs4-A²	regulator of G-protein signalling 4	78.67(n)		AF263451.1
zebrafish (Danio rerio)	Actinopterygii	rgs4²	regulator of G-protein signalling 4	74(n)		321256 AY423029.1
worm (Caenorhabditis elegans)	Secernentea	rgs-7⁶ rgs-4⁶	Regulator of G-protein signaling rgs-7 Regulator of G protein Signaling family member (rg...	9(a) 20(a)	1 ↔ many possible ortholog	X(3542545-3557581) II(12667632-12671556)

ENSEMBL Gene Tree for RGS4 (if available)
TreeFam Gene Tree for RGS4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RGS4 gene

RGS2² RGS8² RGS19² RGS21² RGS3² RGS16² RGS20² RGS5²

RGS17² RGS1² RGS18² RGS13²

18/19 SIMAP similar genes for RGS4 using alignment to 3 protein entries: RGS4_HUMAN (see all proteins) (see all similar genes):

RGS5 RGS3 RGS8 RGS18 RGS21 RGS13

RGS1 RGS16 RGS2 RGS17 RGS20 RGS10

RGS19 RGS7 RGS6 RGS12 RGS14 RGS11

RGS4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148354656^1,2		--	163036466(+)	`AAACAA/GCACCT`	1	--	us2k¹		0	--	--	--	--
rs12043369^1,2	C,F,A,H,	--	163036480(+)	`ACAGAG/ATAGGT`	1	--	us2k¹		26		NS EA EU NA WA	2896
rs2661328^1,2	C,	--	163036515(-)	`TATTTA/GTTCAT`	1	--	us2k¹ tfbs³		11		NA WA CSA EA	372
rs186668161^1,2		--	163036562(+)	`TACCAC/GAGTCA`	1	--	us2k¹		0	--	--	--	--
rs192020569^1,2		--	163036583(+)	`ACAAAC/TCATAG`	1	--	us2k¹		0	--	--	--	--
rs182954627^1,2		--	163036668(+)	`TCCTCA/GCCTCC`	1	--	us2k¹		0	--	--	--	--
rs79013223^1,2		--	163036722(+)	`TCATGG/TGAAGC`	1	--	us2k¹		0	--	--	--	--
rs115230970^1,2		--	163036798(+)	`GTGAGT/AAAACA`	2	--	us2k¹		1		WA	118
rs189659109^1,2		--	163036865(+)	`TATGTC/GTTGAA`	2	--	us2k¹		0	--	--	--	--
rs141720318^1,2		--	163036972(+)	`CTGTGG/TATAAT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RGS4 (163038396 - 163046592 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RGS4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS4

DNA2.0 Custom Variant and Variant Library Synthesis for RGS4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RGS4 for disorders About GeneDecksing

OMIM gene information: 602516 OMIM disorders: --

UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798

Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A

complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content

of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to

the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless

behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are

primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in

which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar

disorder symptoms and are often given the diagnosis of schizoaffective disorder

20/23 diseases for RGS4 (see all 23): About MalaCards

schizophrenia major depressive disorder bipolar i disorder yaws

bipolar disorder psychotic disorder schizoaffective disorder essential hypertension

squamous cell carcinoma alzheimer's disease huntington's disease parkinson's disease

aldosteronism pertussis hypertension dementia

cardiomyopathy breast cancer hypoxia neuroblastoma

1 disease from the University of Copenhagen DISEASES database for RGS4:

Schizophrenia

7 Novoseek disease relationships for RGS4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	71.1	161	18622782 (6), 16565965 (6), 17722013 (6), 17092693 (5) (see all 51)
bipolar disorder	37.1	16	19041089 (2), 17106420 (2), 15660667 (1), 18685145 (1) (see all 6)
psychiatric disorder	13.2	1	17301167 (1)
genetic susceptibility	6.93	2	17092693 (1), 16508931 (1)
hypertrophy	0	4	18207159 (2), 11428836 (1)
alzheimers disease	0	3	16358332 (2), 12422374 (1)
heart failure	0	4	11428836 (2), 12176127 (1), 12559385 (1)

Genetic Association Database (GAD): RGS4
Human Genome Epidemiology (HuGE) Navigator: RGS4 (46 documents)

Export disorders for RGS4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RGS4 gene, integrated from 9 sources (see all 209):
(articles sorted by number of sources associating them with RGS4)

Utopia: connect your pdf to the dynamic
world of online information

Confirming RGS4 as a susceptibility gene for schizophrenia. (PubMed id 14755443)^{1, 2, 4, 9} Morris D.W.... Corvin A.P. (2004)
Association and linkage analyses of RGS4 polymorphisms in schizophrenia. (PubMed id 12023979)^{1, 2, 4, 9} Chowdari K.V.... Nimgaonkar V.L. (2002)
Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PubMed id 8602223)^{1, 2, 3} Druey K.M.... Kehrl J.H. (1996)
Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain. (PubMed id 17707117)^{1, 2, 9} Ding L.... Hegde A.N. (2007)
Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. (PubMed id 10608901)^{1, 2, 9} Tu Y.... Ross E.M. (1999)
Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients. (PubMed id 15381923)^{1, 4, 9} Prasad K.M....Keshavan M.S. (2005)
Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia. (PubMed id 16176390)^{1, 4, 9} Zhang F....Li T. (2005)
Failure to confirm association between RGS4 haplotypes and schizophrenia in Caucasians. (PubMed id 16082709)^{1, 4, 9} Sobell J.L....Heston L.L. (2005)
Association and linkage analysis of RGS4 polymorphisms with schizophrenia and bipolar disorder in Brazil. (PubMed id 15660667)^{1, 4, 9} Cordeiro Q....Vallada H. (2005)
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. (PubMed id 8756726)^{1, 3, 9} Berman D.M....Gilman A.G. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5999	HGNC: 10000	AceView: RGS4	Ensembl:ENSG00000117152	euGenes: HUgn5999
ECgene: RGS4	H-InvDB: RGS4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RGS4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RGS4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RGS4 gene:
Search GeneIP for patents involving RGS4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for RGS4		OriGene shRNA RFP for RGS4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS4
	OriGene Protein Over-expression Lysate for RGS4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RGS4		OriGene 3'-UTR Clone for RGS4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for RGS4		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RGS4		OriGene Custom Protein Services for RGS4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGS4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS4

	GenScript Custom Purified and Recombinant Proteins Services for RGS4		GenScript cDNA clones with any tag delivered in your preferred vector for RGS4
	GenScript Custom Assay Services for RGS4		GenScript Custom Superior Antibodies Services for RGS4
	GenScript Custom overexpressing Cell Line Services for RGS4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for RGS4

	Regulatory tfbs in RGS4 promoter
	Search Chromatin IP Primers for RGS4
	RT² qPCR Primer Assay in human, mouse, rat RGS4
	GNC Network for RGS4
	SABiosciences PCR Arrays including human, mouse, rat RGS4

Tocris compounds for RGS4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RGS4 antibodies
	RGS4 proteins
	RGS4 lysates

	Antibodies for RGS4
	See all of Abcam's Antibodies, Kits and Proteins for RGS4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for RGS4

RGS4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RGS4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS4

	SwitchGear 3'UTR luciferase reporter plasmids for RGS4
	SwitchGear Promoter luciferase reporter plasmids for RGS4

ThermoFisher Antibody for RGS4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RGS4 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RGS4 Gene

regulator of G-protein signaling 4

Aliases
for RGS4 gene

Summaries
for RGS4 gene

Genomic Views
for RGS4 gene

Proteins
for RGS4 gene

Protein Domains /
Families
for RGS4 gene

Function
for RGS4 gene

Pathways & Interactions
for RGS4 gene

Drugs & Compounds
for RGS4 gene

Transcripts
for RGS4 gene

Expression
for RGS4 gene

Orthologs
for RGS4 gene

Paralogs
for RGS4 gene

Genomic Variants
for RGS4 gene

Disorders / Diseases
for RGS4 gene

Publications
for RGS4 gene

External Searches for RGS4 gene

Genome Databases showing RGS4 gene

Other Databases showing RGS4 gene

Specialized Databases showing RGS4 gene

Intellectual Property
for RGS4 gene

Products
for RGS4 gene

View Random Gene

Advanced Search

Export list of displayed genes

RGS4 Gene

regulator of G-protein signaling 4

Aliasesfor RGS4 gene

Summariesfor RGS4 gene

Genomic Viewsfor RGS4 gene

Proteinsfor RGS4 gene

Protein Domains /Familiesfor RGS4 gene

Functionfor RGS4 gene

Pathways & Interactionsfor RGS4 gene

Drugs & Compoundsfor RGS4 gene

Transcriptsfor RGS4 gene

Expression for RGS4 gene

Orthologsfor RGS4 gene

Paralogsfor RGS4 gene

Genomic Variantsfor RGS4 gene

Disorders / Diseasesfor RGS4 gene

Publicationsfor RGS4 gene

External Searches for RGS4 gene

Genome Databases showing RGS4 gene

Other Databases showing RGS4 gene

Specialized Databases showing RGS4 gene

Intellectual Propertyfor RGS4 gene

Productsfor RGS4 gene

View Random Gene

Aliases
for RGS4 gene

Summaries
for RGS4 gene

Genomic Views
for RGS4 gene

Proteins
for RGS4 gene

Protein Domains /
Families
for RGS4 gene

Function
for RGS4 gene

Pathways & Interactions
for RGS4 gene

Drugs & Compounds
for RGS4 gene

Transcripts
for RGS4 gene

Expression
for RGS4 gene

Orthologs
for RGS4 gene

Paralogs
for RGS4 gene

Genomic Variants
for RGS4 gene

Disorders / Diseases
for RGS4 gene

Publications
for RGS4 gene

Intellectual Property
for RGS4 gene

Products
for RGS4 gene