Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS4 Gene

Aliases for RGS4 Gene

  • Regulator Of G-Protein Signaling 4 2 3
  • Schizophrenia Disorder 9 2 3
  • RGP4 3 4
  • Regulator Of G-Protein Signalling 4 2
  • SCZD9 3

External Ids for RGS4 Gene

Previous Symbols for RGS4 Gene

  • SCZD9

Summaries for RGS4 Gene

Entrez Gene Summary for RGS4 Gene

  • Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS4 Gene

RGS4 (Regulator Of G-Protein Signaling 4) is a Protein Coding gene. Diseases associated with RGS4 include schizophrenia. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS4 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein

Tocris Summary for RGS4 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the off state. Ligand-receptor binding results in detachment of the G protein, switching it to an on state and permitting Galpha activation of second messenger signalling cascades. Regulators of G protein signalling, such as RGS4, promote GTP hydrolysis by the alpha subunit in order to inactivate the G protein.

Gene Wiki entry for RGS4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS4 Gene

Genomics for RGS4 Gene

Genomic Location for RGS4 Gene

163,068,606 bp from pter
163,076,802 bp from pter
8,197 bases
Plus strand

Genomic View for RGS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS4 Gene

Regulatory Elements for RGS4 Gene

Proteins for RGS4 Gene

  • Protein details for RGS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 4
    Protein Accession:
    Secondary Accessions:
    • A7XA56
    • A7XA58
    • A7XA59
    • A7YVV7
    • B1APZ3

    Protein attributes for RGS4 Gene

    205 amino acids
    Molecular mass:
    23256 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RGS4 Gene


neXtProt entry for RGS4 Gene

Proteomics data for RGS4 Gene at MOPED

Post-translational modifications for RGS4 Gene

Other Protein References for RGS4 Gene

No data available for DME Specific Peptides for RGS4 Gene

Domains for RGS4 Gene

Gene Families for RGS4 Gene

  • RGS :Regulators of G-protein signaling

Protein Domains for RGS4 Gene


  • Contains 1 RGS domain.:
    • P49798
genes like me logo Genes that share domains with RGS4: view

Function for RGS4 Gene

Molecular function for RGS4 Gene

UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein

Gene Ontology (GO) - Molecular Function for RGS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0005096 GTPase activator activity IBA --
GO:0005516 calmodulin binding TAS 10747990
genes like me logo Genes that share ontologies with RGS4: view
genes like me logo Genes that share phenotypes with RGS4: view

Animal Models for RGS4 Gene

MGI Knock Outs for RGS4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RGS4 Gene

Localization for RGS4 Gene

Subcellular locations from

Jensen Localization Image for RGS4 Gene COMPARTMENTS Subcellular localization image for RGS4 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RGS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10791963
GO:0005737 cytoplasm IDA 10791963
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RGS4: view

Pathways for RGS4 Gene

genes like me logo Genes that share pathways with RGS4: view

Pathways by source for RGS4 Gene

Gene Ontology (GO) - Biological Process for RGS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8602223
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10747990
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway --
genes like me logo Genes that share ontologies with RGS4: view

Compounds for RGS4 Gene

(5) Tocris Compounds for RGS4 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
Gallein Inhibitor of betagamma signaling [2103-64-2]
G-Protein antagonist peptide Inhibits G protein activation by GPCRs [143675-79-0]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]

(20) Novoseek inferred chemical compound relationships for RGS4 Gene

Compound -log(P) Hits PubMed IDs
gtp 70.1 18
phosphatidylinositol-3,4,5-trisphosphate 66.9 3
damgo 37.7 4
gdp 30.2 1
dopamine 28.5 7

(6) PharmGKB related drug/compound annotations for RGS4 Gene

Drug/compound Annotation
antipsychotics CA
olanzapine CA
perphenazine CA
quetiapine CA
risperidone CA
ziprasidone CA
genes like me logo Genes that share compounds with RGS4: view

Transcripts for RGS4 Gene

Unigene Clusters for RGS4 Gene

Regulator of G-protein signaling 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP6: - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - -

Relevant External Links for RGS4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS4 Gene

mRNA expression in normal human tissues for RGS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (12.4), Brain - Anterior cingulate cortex (BA24) (10.8), and Brain - Cortex (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGS4 Gene

SOURCE GeneReport for Unigene cluster for RGS4 Gene Hs.386726

mRNA Expression by UniProt/SwissProt for RGS4 Gene

Tissue specificity: Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.
genes like me logo Genes that share expressions with RGS4: view

Orthologs for RGS4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS4 36
  • 99.56 (n)
  • 100 (a)
RGS4 37
  • 100 (a)
(Bos Taurus)
Mammalia RGS4 36
  • 92.85 (n)
  • 97.07 (a)
RGS4 37
  • 85 (a)
(Canis familiaris)
Mammalia RGS4 36
  • 92.36 (n)
  • 94.63 (a)
RGS4 37
  • 95 (a)
(Mus musculus)
Mammalia Rgs4 36
  • 89.43 (n)
  • 96.1 (a)
Rgs4 16
Rgs4 37
  • 96 (a)
(Monodelphis domestica)
Mammalia RGS4 37
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 44 (a)
(Rattus norvegicus)
Mammalia Rgs4 36
  • 90.24 (n)
  • 97.07 (a)
(Gallus gallus)
Aves RGS4 36
  • 75.49 (n)
  • 77.45 (a)
RGS4 37
  • 75 (a)
(Anolis carolinensis)
Reptilia RGS4 37
  • 5 (a)
African clawed frog
(Xenopus laevis)
Amphibia rgs4-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76188 36
rgs4 36
  • 68.28 (n)
  • 69.42 (a)
(Danio rerio)
Actinopterygii rgs4 36
rgs4 36
  • 59.11 (n)
  • 49.26 (a)
rgs4 37
  • 47 (a)
Species with no ortholog for RGS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS4 Gene

Gene Tree for RGS4 (if available)
Gene Tree for RGS4 (if available)

Paralogs for RGS4 Gene

Paralogs for RGS4 Gene

Selected SIMAP similar genes for RGS4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGS4: view

Variants for RGS4 Gene

Sequence variations from dbSNP and Humsavar for RGS4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10759 -- 163,076,561(-) TTCAG(A/C)GTGAC utr-variant-3-prime
rs14665 - 163,074,525(+) GTTCA(G/T)CAGAC reference, missense, utr-variant-3-prime
rs2344671 -- 163,071,074(+) CTCAG(A/G)TGGAT intron-variant, upstream-variant-2KB
rs2661317 -- 163,070,037(-) CATTT(G/T)CTTAT intron-variant, upstream-variant-2KB
rs2661318 -- 163,075,767(-) AATAT(A/G)GGCAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RGS4 Gene

Variant ID Type Subtype PubMed ID
nsv3332 CNV Insertion 18451855

Relevant External Links for RGS4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for RGS4 Gene


  • Schizophrenia 9 (SCZD9) [MIM:604906]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:12023979, ECO:0000269 PubMed:14755443}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) MalaCards Diseases for RGS4 Gene

Search for RGS4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RGS4 Gene

(7) Novoseek inferred disease relationships for RGS4 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 71.1 119
bipolar disorder 37.1 8
psychiatric disorder 13.2 1
genetic susceptibility 6.93 2
hypertrophy 0 3

Relevant External Links for RGS4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RGS4: view

Publications for RGS4 Gene

  1. Association and linkage analyses of RGS4 polymorphisms in schizophrenia. (PMID: 12023979) Chowdari K.V. … Nimgaonkar V.L. (Hum. Mol. Genet. 2002) 3 4 23 49
  2. Confirming RGS4 as a susceptibility gene for schizophrenia. (PMID: 14755443) Morris D.W. … Corvin A.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 4 23 49
  3. Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients. (PMID: 15381923) Prasad K.M. … Keshavan M.S. (Mol. Psychiatry 2005) 3 23 49
  4. Failure to confirm association between RGS4 haplotypes and schizophrenia in Caucasians. (PMID: 16082709) Sobell J.L. … Heston L.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005) 3 23 49
  5. Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia. (PMID: 16176390) Zhang F. … Li T. (Genes Brain Behav. 2005) 3 23 49

Products for RGS4 Gene

Sources for RGS4 Gene

Back to Top