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RGS4 Gene

protein-coding   GIFtS: 60
GCID: GC01P163038

Regulator Of G-Protein Signaling 4

(Previous names: regulator of G-protein signalling 4, schizophrenia disorder...)
(Previous symbol: SCZD9)
  See RGS4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 41 2
SCZD91 2
Schizophrenia Disorder 91 2
RGP42 3
Regulator Of G-Protein Signalling 41

External Ids:    HGNC: 100001   Entrez Gene: 59992   Ensembl: ENSG000001171527   OMIM: 6025165   UniProtKB: P497983   

Export aliases for RGS4 gene to outside databases

Previous GC identifers: GC01P160674 GC01P158689 GC01P159735 GC01P160226 GC01P159770 GC01P161305 GC01P134283


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS4 Gene:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating
proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein
subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound
forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino
acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97%
identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric
G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS4 Gene:
RGS4 (regulator of G-protein signaling 4) is a protein-coding gene. Diseases associated with RGS4 include schizophrenia. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the
G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein

summary for RGS4 Gene:
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein
contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding
results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of
second messenger signalling cascades. Regulators of G protein signalling, such as RGS4, promote GTP
hydrolysis by the alpha subunit in order to inactivate the G protein.

Gene Wiki entry for RGS4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS4 gene promoter:
         CREB   SRF (504 AA)   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS4 promoter sequence
   Search Chromatin IP Primers for RGS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

RGS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P163038:  view genomic region     (about GC identifiers)

Start:
163,038,396 bp from pter      End:
163,046,592 bp from pter
Size:
8,197 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 4  
Size: 205 amino acids; 23256 Da
Secondary accessions: A7XA56 A7XA58 A7XA59 A7YVV7 B1APZ3
Alternative splicing: 5 isoforms:  P49798-1   P49798-2   P49798-3   P49798-4   P49798-5   

Explore the universe of human proteins at neXtProt for RGS4: NX_P49798

Explore proteomics data for RGS4 at MOPED

Post-translational modifications: 

  • Palmitoylated on Cys-2 and/or Cys-121
  • Phosphorylated by cyclic GMP-dependent protein kinase (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001095915.1  NP_001106851.1  NP_001106852.1  NP_005604.1  

    ENSEMBL proteins: 
     ENSP00000397181   ENSP00000356885   ENSP00000436106   ENSP00000433261   ENSP00000356884  
     ENSP00000356882   ENSP00000432194  
    Reactome Protein details: P49798

    RGS4 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for RGS4
    Novus Biologicals RGS4 Proteins
    Novus Biologicals RGS4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RGS4
    Cloud-Clone Corp. Proteins for RGS4

     
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    Cloud-Clone Corp. ELISAs for RGS4
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    Search eBioscience for ELISAs for RGS4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry P49798

    ProtoNet protein and cluster: P49798

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798
    Similarity: Contains 1 RGS domain


    Find genes that share domains with RGS4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS4_HUMAN, P49798
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the
    G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0005096GTPase activator activity IBA--
    GO:0005516calmodulin binding TAS10747990
         
    Find genes that share ontologies with RGS4           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Rgs4):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  integument  mortality/aging  nervous system 
     no phenotypic analysis  normal  renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with RGS4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RGS4: Rgs4tm1.1Jlr Rgs4tm1.1Amus

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RGS4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGS4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGS4

    miRNA
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    Block miRNA regulation of human, mouse, rat RGS4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGS4 (see all 29):
    hsa-miR-498 hsa-miR-136 hsa-miR-146b-3p hsa-miR-16-2* hsa-miR-125a-3p hsa-miR-340 hsa-miR-520a-5p hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidRGS4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RGS4
    Predesigned siRNA for gene silencing in human, mouse, rat RGS4

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for RGS4 (see all 21)
    OriGene ORF clones in mouse, rat for RGS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RGS4 (NM_001102445)
    Sino Biological Human cDNA Clone for RGS4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS4

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13178) for RGS4 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    plasma membrane3
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IBA--
    GO:0016020membrane ----
    GO:0043234protein complex IEA--

    Find genes that share ontologies with RGS4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS4 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    4Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    5ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47


    Find genes that share SuperPaths with RGS4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS4
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    2 Cell Signaling Technology (CST) Pathways for RGS4
        Ca, cAMP and Lipid Signaling
    Neuroscience

    2 BioSystems Pathways for RGS4
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell


    2 Reactome Pathways for RGS4
        G alpha (i) signalling events
    G alpha (z) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Arrays including RGS4: 
              Parkinson's Disease in human mouse rat
              Huntington's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RGS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RGS4 (P497983 ENSP000003971814) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPB2P356063, ENSP000003294194I2D: score=1 STRING: ENSP00000329419
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    KRIT1O005223, ENSP000003446684I2D: score=1 STRING: ENSP00000344668
    GNAI1P630963, ENSP000003430274I2D: score=3 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity TAS8602223
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS10747990
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity ----
    GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway ----

    Find genes that share ontologies with RGS4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RGS4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GalleinInhibitor of betagamma signaling[2103-64-2]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    G-Protein antagonist peptideInhibits G protein activation by GPCRs[143675-79-0]
    8-Bromo-cGMP, sodium salt cGMP analog; activates PKG[51116-01-9]
    Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]

    Selected Novoseek inferred chemical compound relationships for RGS4 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 70.1 19 9430692 (3), 9108480 (2), 10387017 (2), 10807934 (2) (see all 13)
    phosphatidylinositol-3,4,5-trisphosphate 66.9 3 15324308 (2), 11148035 (1)
    damgo 37.7 4 20002516 (2), 11755131 (1), 16377088 (1)
    gdp 30.2 1 8774882 (1)
    dopamine 28.5 13 16905560 (2), 18815258 (1), 16565965 (1), 16082709 (1) (see all 6)
    quinpirole 23.6 2 17179741 (1), 12603835 (1)
    phosphoinositide 13.2 7 16885398 (4), 15383626 (1), 9115254 (1)
    cysteine 10 10 12753087 (2), 12642592 (2), 17660054 (1), 11274219 (1) (see all 6)
    acetylcholine 7.09 1 12538649 (1)
    forskolin 6.46 1 15369705 (1)

    6 PharmGKB related drug/compound annotations for RGS4 gene    About this table
    Drug/compound PharmGKB Annotation
    antipsychoticsCA  
    olanzapineCA  
    perphenazineCA  
    quetiapineCA  
    risperidoneCA  
    ziprasidoneCA  



    Find genes that share compounds with RGS4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGS4 gene (4 alternative transcripts): 
    NM_001102445.2  NM_001113380.1  NM_001113381.1  NM_005613.5  

    Unigene Cluster for RGS4:

    Regulator of G-protein signaling 4
    Hs.386726  [show with all ESTs]
    Unigene Representative Sequence: NM_001102445
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421743(uc001gcl.4) ENST00000527393 ENST00000367909(uc009wuy.3 uc009wuz.3 uc009wva.3)
    ENST00000531057 ENST00000527809 ENST00000367908 ENST00000491263 ENST00000533019
    ENST00000367906 ENST00000528938
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RGS4 (see all 29):
    hsa-miR-498 hsa-miR-136 hsa-miR-146b-3p hsa-miR-16-2* hsa-miR-125a-3p hsa-miR-340 hsa-miR-520a-5p hsa-miR-1297
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RGS4
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): RGS4 (NM_001102445)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS4
    Primer
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    OriGene qPCR primer pairs and template standards for RGS4
    OriGene qSTAR qPCR primer pairs in human, mouse for RGS4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RGS4
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    eBioscience FlowRNA Probe Sets ( VA1-13178) for RGS4 

    Additional mRNA sequence: 

    AF493928.1 AK093959.1 AK295540.1 AK296240.1 AK300832.1 AK312250.1 AL137433.1 BC000737.1 
    BC051869.1 BT007025.1 DQ346662.1 DQ346663.1 DQ346664.1 EF054877.1 U27768.1 

    13 DOTS entries:

    DT.100790591  DT.100044434  DT.100790597  DT.441476  DT.100790592  DT.100790594  DT.100790593  DT.121437776 
    DT.121437810  DT.100044436  DT.121437755  DT.121437806  DT.121437756 

    Selected AceView cDNA sequences (see all 204):

    F08686 CB143414 BP337084 AA669905 CN482582 BU149136 AA776229 CR612216 
    CN481874 CD679102 BU743084 BP342248 AA595701 F12423 CN484299 CD671309 
    BE889095 BM930153 BP336664 AW449093 BU507128 BQ716631 BU509460 CB156521 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RGS4 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
    SP1:              -                             -     -                                                                                       
    SP2:                                            -     -                                                                                       
    SP3:                                            -     -                                                                                       
    SP4:                                      -     -     -                                                                                       
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for RGS4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTGATAG
    RGS4 Expression
    About this image


    RGS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             Midbrain dopaminergic-like neurons
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
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             Human embryonic stem cells (family)
    RGS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.386726

    UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798
    Tissue specificity: Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and
    visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not
    expressed in the cerebellum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RGS4: 
              Parkinson's Disease in human mouse rat
              Huntington's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RGS4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs41 , 5 regulator of G-protein signaling 41, 5 89.43(n)1
    96.1(a)1
      1 (76.84 cM)5
    197361  NM_009062.31  NP_033088.21 
     1697414775 
    chicken
    (Gallus gallus)
    Aves RGS41 regulator of G-protein signaling 4 75.49(n)
    77.45(a)
      378901  NM_204385.1  NP_989716.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS46
    regulator of G-protein signaling 4
    5(a)
    1 ↔ 1
    AAWZ02036294(4846-27569)
    African clawed frog
    (Xenopus laevis)
    Amphibia rgs4-A2 regulator of G-protein signalling 4 78.67(n)    AF263451.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgs42 regulator of G-protein signalling 4 74(n)   321256  AY423029.1 


    ENSEMBL Gene Tree for RGS4 (if available)
    TreeFam Gene Tree for RGS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS4 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS162  RGS172  
    RGS52  RGS12  RGS182  RGS132  
    Selected SIMAP similar genes for RGS4 using alignment to 3 protein entries:     RGS4_HUMAN (see all proteins) (see all similar genes):
    RGS5    RGS3    RGS8    RGS18    RGS21    RGS13
    RGS1    RGS16    RGS2    RGS17    RGS20    RGS10
    RGS19    RGS6    RGS7    RGS12    RGS14    RGS11

    Find genes that share paralogs with RGS4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS4 (see all 239)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999202921,2
    C--163038325(+) TGGAG-/TT    
       TGGAG
    ACTTA
    3 -- us2k10--------
    rs1928281181,2
    --163041648(+) TTGCCC/GCCCCC 4 -- int1 us2k10--------
    rs57783121,2
    C--163042020(+) GAACCAA/-AAGAG 4 -- int13Minor allele frequency- -:0.12NA CSA 8
    rs57783131,2
    C--163044893(+) TGTAT-/ACAC  
            
    ACACA
    4 -- ut311Minor allele frequency- ACAC:0.00NA 2
    rs671873581,2
    C--163045749(-) TTTTT-/TCTTTT 4 -- ut311Minor allele frequency- T:0.00NA 2
    rs1483546561,2
    --169586467(+) AAACAA/GCACCT 1 -- us2k10--------
    rs120433691,2
    C,F,A,H--169586481(+) ACAGAG/ATAGGT 1 -- us2k126Minor allele frequency- A:0.32NS EA EU NA WA 2896
    rs26613281,2
    C--169586516(-) TATTTA/GTTCAT 1 -- us2k1 tfbs311Minor allele frequency- G:0.01NA WA CSA EA 372
    rs1866681611,2
    --169586563(+) TACCAC/GAGTCA 1 -- us2k10--------
    rs1920205691,2
    --169586584(+) ACAAAC/TCATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGS4 (163038396 - 163046592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RGS4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3332CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS4
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602516    OMIM disorders: --

    UniProtKB/Swiss-Prot: RGS4_HUMAN, P49798
  • Schizophrenia 9 (SCZD9) [MIM:604906]: A complex, multifactorial psychotic disorder or group of disorders
    characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g.
    inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries,
    withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it
    is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild
    impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive
    function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are
    often given the diagnosis of schizoaffective disorder. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry

  • 1 disease for RGS4:    
    About MalaCards
    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for RGS4:
    Schizophrenia

    Find genes that share disorders with RGS4           About GenesLikeMe

    7 Novoseek inferred disease relationships for RGS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 71.1 161 18622782 (6), 16565965 (6), 17722013 (6), 17092693 (5) (see all 51)
    bipolar disorder 37.1 16 19041089 (2), 17106420 (2), 15660667 (1), 18685145 (1) (see all 6)
    psychiatric disorder 13.2 1 17301167 (1)
    genetic susceptibility 6.93 2 17092693 (1), 16508931 (1)
    hypertrophy 0 4 18207159 (2), 11428836 (1)
    alzheimers disease 0 3 16358332 (2), 12422374 (1)
    heart failure 0 4 11428836 (2), 12176127 (1), 12559385 (1)

    Genetic Association Database (GAD): RGS4
    Human Genome Epidemiology (HuGE) Navigator: RGS4 (46 documents)

    Export disorders for RGS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS4 gene, integrated from 10 sources (see all 216):
    (articles sorted by number of sources associating them with RGS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Confirming RGS4 as a susceptibility gene for schizophrenia. (PubMed id 14755443)1, 2, 4, 9 Morris D.W.... Corvin A.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    2. Association and linkage analyses of RGS4 polymorphisms in schizophrenia. (PubMed id 12023979)1, 2, 4, 9 Chowdari K.V.... Nimgaonkar V.L. (Hum. Mol. Genet. 2002)
    3. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PubMed id 8602223)1, 2, 3 Druey K.M.... Kehrl J.H. (Nature 1996)
    4. Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia. (PubMed id 17588543)1, 4, 9 Campbell D.B....Sullivan P.F. (Biol. Psychiatry 2008)
    5. Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain. (PubMed id 17707117)1, 2, 9 Ding L.... Hegde A.N. (Gene 2007)
    6. Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. (PubMed id 10608901)1, 2, 9 Tu Y.... Ross E.M. (J. Biol. Chem. 1999)
    7. An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population. (PubMed id 17722013)1, 4, 9 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    8. Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level. (PubMed id 18834502)1, 4, 9 Stefanis N.C....Stefanis C.N. (Behav Brain Funct 2008)
    9. Allelic variation in RGS4 impacts functional and structural connectivity in the human brain. (PubMed id 17301167)1, 4, 9 Buckholtz J.W....Callicott J.H. (J. Neurosci. 2007)
    10. Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4). (PubMed id 16508931)1, 4, 9 Rizig M.A....Gurling H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5999 HGNC: 10000 AceView: RGS4 Ensembl:ENSG00000117152 euGenes: HUgn5999
    ECgene: RGS4 H-InvDB: RGS4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RGS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS4 gene:
    Search GeneIP for patents involving RGS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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