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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGS3 Gene

protein-coding GIFtS: 64
GCID: GC09P116207

regulator of G-protein signaling 3

(Previous name: regulator of G-protein signalling 3 )

Explore 9 diseases affiliated with
RGS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 3¹ ²
C2PA¹ ²
Regulator Of G-Protein Signalling 3¹ ²
RGP3² ³
FLJ20370¹
PDZ-RGS3¹

External Ids:	HGNC: 9999¹	Entrez Gene: 5998²	Ensembl: ENSG00000138835⁷	OMIM: 602189⁵	UniProtKB: P49796³

Export aliases for RGS3 gene to outside databases

Previous GC identifers: GC09P107022 GC09P107956 GC09P109678 GC09P111600 GC09P113303 GC09P115262 GC09P085814

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS3:

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating

protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative

promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and

plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while

shorter N-terminally-truncated isoforms can be nuclear. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: RGS3_HUMAN, P49796

Function: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha

subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of

inositol phosphates and activation of MAP kinases

Gene Wiki entry for RGS3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGS3 gene promoter:
ER-alpha HEN1 GR Pbx1a AP-1 Lmo2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RGS3 promoter sequence

Search SABiosciences Chromatin IP Primers for RGS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q32

RGS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS3 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P116207: view genomic region (about GC identifiers)

Start:	116,207,011 bp from pter	End:	116,360,018 bp from pter
Size:	153,008 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGS3_HUMAN, P49796 (See protein sequence)

Recommended Name: Regulator of G-protein signaling 3

Size: 1198 amino acids; 132336 Da

Subunit: Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer

Subcellular location: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein (Potential). Note=Long isoforms

are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear

Sequence caution: Sequence=AAM33254.1; Type=Erroneous initiation;

3 PDB 3D structures from and Proteopedia for RGS3:

2F5Y (3D)

2OJ4 (3D)

3FBK (3D)

Secondary accessions: A6NHA0 A8K0V1 Q5VXB8 Q5VXC1 Q5VZ05 Q6ZRM5 Q8IUQ1 Q8NC47 Q8NFN4 Q8NFN5 Q8TD59

Q8TD68 Q8WXA0

Alternative splicing: 6 isoforms: P49796-3 P49796-1 P49796-2 P49796-4 P49796-5 P49796-6 (Nuclear)

Explore the universe of human proteins at neXtProt for RGS3: NX_P49796

Post-translational modifications:

Phosphorylated by cyclic GMP-dependent protein kinase (By similarity)¹

ISGylated (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49796

RGS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (9 alternative transcripts):

NP_001263189.1 NP_001263190.1 NP_001263191.1 NP_060260.3 NP_066929.1 NP_570613.2 NP_602299.1 NP_652759.3

NP_652760.2

ENSEMBL proteins:

ENSP00000363255 ENSP00000312844 ENSP00000340284 ENSP00000363251 ENSP00000418898

ENSP00000420663 ENSP00000420356 ENSP00000363249 ENSP00000417866 ENSP00000417994

ENSP00000436168 ENSP00000259406 ENSP00000378141 ENSP00000343359

Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 3): RGS3 OriGene Protein Over-expression Lysate (see all 4): RGS3 OriGene Custom Protein Services for RGS3
	GenScript Custom Purified and Recombinant Proteins Services for RGS3
	Novus Biologicals RGS3 Protein Novus Biologicals RGS3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RGS3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IBA	--
GO:0005829	cytosol	TAS	9858594
GO:0005886	plasma membrane	IBA	--

RGS3 for ontologies About GeneDecksing

RGS3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for RGS3
	Novus Biologicals RGS3 Antibodies
	Search for Antibodies for RGS3 at Abcam
	Uscn Antibodies for RGS3
	ThermoFisher Antibodies for RGS3

Assay Products for RGS3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RGS3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RGS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGS3 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR024066 Regulat_G_prot_signal_dom1

IPR018029 C2_membr_targeting

IPR011993 PH_like_dom

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR001478 PDZ

Graphical View of Domain Structure for InterPro Entry P49796

ProtoNet protein and cluster: P49796

2 Blocks protein families:

IPB000008 C2 domain

IPB000342 Regulator of G-protein signalling (RGS) protein signature

UniProtKB/Swiss-Prot: RGS3_HUMAN, P49796

Similarity: Contains 1 C2 domain

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 RGS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RGS3_HUMAN, P49796

Function: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha

subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of

inositol phosphates and activation of MAP kinases

Genatlas biochemistry entry for RGS3:

negative regulator of G protein signaling 3,functioning as GTPase-activating protein for G protein alpha i and q

subunits,expressed in heart,skeletal muscle,lung and other tissues,C elegans EGL-10 and yeast SST2 homolog

miRNA Products:		miRTarBase miRNAs that target RGS3: hsa-mir-126 (MIRT000966)

		OriGene 3'-UTR Clone (see all 6): RGS3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS3
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS3 (see all 33):
		hsa-miR-3685 hsa-miR-126 hsa-miR-1321 hsa-miR-4318 hsa-miR-25 hsa-miR-575 hsa-miR-4258 hsa-miR-3142

		SwitchGear 3'UTR luciferase reporter plasmid: RGS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS3 (see all 7) OriGene shRNA RFP: RGS3 OriGene siRNA: RGS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RGS3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 6): RGS3 (NM_017790)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RGS3
		Search LifeMap BioReagents cell lines for RGS3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IBA	--

RGS3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RGS3:

Increased cilium length after

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling_G-Protein beta/gamma signaling cascades

G-protein signaling_G-Protein beta/gamma signaling cascades

1.00

G-protein signaling G-Protein beta/gamma signaling cascades

0.98

Cytoskeleton remodeling_Reverse signaling by ephrin B

Cytoskeleton remodeling_Reverse signaling by ephrin B

1.00

Cytoskeleton remodeling Reverse signaling by ephrin B

0.94

Cell adhesion_Ephrins signaling

Cell adhesion Ephrins signaling

1.00

Cell adhesion_Ephrins signaling

1.00

Calcium Regulation in the Cardiac Cell

Calcium Regulation in the Cardiac Cell

1.00

Myometrial Relaxation and Contraction Pathways

0.43

G-AlphaQ Signaling

G-AlphaQ Signaling

1.00

G-AlphaI Signaling

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for RGS3

	G-protein signaling G-Protein beta/gamma signaling cascades
	G-protein signaling G-Protein alpha-q signaling cascades
	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cell adhesion Ephrins signaling

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS3

	EphB-EphrinB Signaling
	cAMP Pathway
	Ephrin-Eph Signaling
	G-AlphaI Signaling
	G-AlphaQ Signaling

4 GeneGo (Thomson Reuters) Pathways for RGS3

	G-protein signaling G-Protein alpha-q signaling cascades
	G-protein signaling G-Protein beta/gamma signaling cascades
	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cell adhesion Ephrins signaling

3 BioSystems Pathways for RGS3

	Calcium Regulation in the Cardiac Cell
	Myometrial Relaxation and Contraction Pathways
	Ephrin B reverse signaling

1 Kegg Pathway (Kegg details for RGS3):

Axon guidance

RGS3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RGS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/41 Interacting proteins for RGS3 (P49796^{2, 3} ENSP00000259406⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-8009863 MINT-8007214 I2D: score=4 STRING: ENSP00000309503
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-19381 I2D: score=3 STRING: ENSP00000300161
YWHAQ	P27348²^,³, ENSP00000238081⁴	MINT-8007221 I2D: score=3 STRING: ENSP00000238081
EFNB1	P98172³, ENSP00000204961⁴	I2D: score=2 STRING: ENSP00000204961
YWHAE	P62258³, ENSP00000264335⁴	I2D: score=2 STRING: ENSP00000264335

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000188	inactivation of MAPK activity	TAS	8602223
GO:0007165	signal transduction	--	--
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	TAS	9858594
GO:0038032	termination of G-protein coupled receptor signaling pathway	IEA	--
GO:0043547	positive regulation of GTPase activity	TAS	9858594

RGS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RGS3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGS3
3 Novoseek chemical compound relationships for RGS3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	42.4	1	11294858 (1)
gnrh	32.5	6	9003025 (3), 11897687 (3)
calcium	17.9	15	12771384 (5), 9858594 (2), 16855219 (1), 15488173 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about RGS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGS3 gene (9 alternative transcripts):

NM_001276260.1 NM_001276261.1 NM_001276262.1 NM_017790.4 NM_021106.3 NM_130795.3 NM_134427.2 NM_144488.5

NM_144489.3

Unigene Cluster for RGS3:

Regulator of G-protein signaling 3

Hs.494875 [show with all ESTs]

Unigene Representative Sequence: NM_144488

18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):

ENST00000374140(uc004bhq.3) ENST00000478599(uc004bhs.3) ENST00000317613(uc004bhr.3)

ENST00000466735 ENST00000488259 ENST00000466314 ENST00000343817(uc004bht.3 uc010muy.3)

ENST00000464306 ENST00000374136(uc004bhu.3) ENST00000496113 ENST00000460000

ENST00000470775 ENST00000496264 ENST00000474719 ENST00000462143(uc004bhv.3)

ENST00000492676 ENST00000463806 ENST00000489082

miRNA Products:		OriGene 3'-UTR Clone (see all 6): RGS3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS3
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS3 (see all 33):
		hsa-miR-3685 hsa-miR-126 hsa-miR-1321 hsa-miR-4318 hsa-miR-25 hsa-miR-575 hsa-miR-4258 hsa-miR-3142

		SwitchGear 3'UTR luciferase reporter plasmid: RGS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS3 (see all 7) OriGene shRNA RFP: RGS3 OriGene siRNA: RGS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS3

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS3

Additional cDNA sequence:

AF006609.1 AF463495.1 AF490838.1 AF490839.1 AF490840.1 AF493927.1 AF493941.1 AK000377.1

AK054584.1 AK074977.1 AK096840.1 AK123387.1 AK125059.1 AK125094.1 AK128127.1 AK222888.1

AK226153.1 AK289666.1 AK301515.1 AK309971.1 AK310705.1 AY585192.1 BC018072.1 BC019039.2

BC042555.1 FJ423754.1 U27655.1

24/26 DOTS entries (see all 26):

DT.40250599 DT.444723 DT.100669570 DT.100017186 DT.101983806 DT.101983807 DT.100020408 DT.100029068

DT.100029066 DT.91743435 DT.121163229 DT.121163207 DT.65287437 DT.40204867 DT.40222169 DT.100813046

DT.100813047 DT.97847698 DT.121163181 DT.121163188 DT.40220848 DT.86846311 DT.91906921 DT.121163217

24/246 AceView cDNA sequences (see all 246):

BC019039 BQ012522 BM690084 BM562549 AK096840 BU616693 AA581776 CR618862

AL041598 BM559473 CA448114 CB047631 BU856508 AU280679 CB565903 BM915612

AK125059 AF490840 NM_134427 AI061401 AF006609 BU681994 AK128127 BQ672883

GeneLoc Exon Structure

5/38 Alternative Splicing Database (ASD) splice patterns (SP) for RGS3 (see all 38) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	·	18c	^	19a	·	19b	^	20a	·	20b	^
SP1:									-																-		-		-		-		-												-
SP2:																													-		-		-												-
SP3:																																													-
SP4:
SP5:

ExUns:	21	^	22a	·	22b	^	23	^	24	^	25	^	26	^	27a	·	27b	·	27c	·	27d	·	27e	^	28a	·	28b	^	29a	·	29b	·	29c	·	29d	·	29e	^	30a	·	30b	·	30c	^	31a	·	31b	·	31c	^	32	^
SP1:	-		-				-		-						-		-		-
SP2:	-		-				-		-						-		-		-						-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:	-		-				-		-						-		-		-
SP4:
SP5:	-		-				-		-						-		-		-						-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	33a	·	33b	·	33c	·	33d	·	33e	·	33f	^	34a	·	34b	·	34c	·	34d	·	34e	·	34f	·	34g	·	34h	·	34i	·	34j	·	34k	·	34l	^	35a	·	35b	^	36	^	37a	·	37b	·	37c	·	37d	·	37e	^
SP1:
SP2:	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-
SP3:
SP4:																																											-		-		-		-		-
SP5:	-		-		-		-		-		-

ExUns:	38a	·	38b	^	39a	·	39b	^	40a	·	40b	·	40c	^	41a	·	41b	·	41c	·	41d	·
SP1:
SP2:			-				-		-
SP3:
SP4:			-				-		-
SP5:

ECgene alternative splicing isoforms for RGS3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACCCTCAG

About this image

RGS3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See RGS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGS3

SOURCE GeneReport for Unigene cluster: Hs.494875

SABiosciences Custom PCR Arrays for RGS3

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RGS3 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RGS3⁶	regulator of G-protein signalling 3 RGS3L isoform	68(a)	1 ↔ 1	17(1759910-1810936)
lizard (Anolis carolinensis)	Reptilia	RGS3⁶	--	77(a)	1 ↔ 1	GL344328.1(54350-56844)
zebrafish (Danio rerio)	Actinopterygii	rgs3⁶ AL929150.2⁶ (see all 3)	--	76(a) 42(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	5(73132252-73159766) 1(55542027-55546724)
worm (Caenorhabditis elegans)	Secernentea	rgs-4⁶ rgs-7⁶	Regulator of G-protein signaling rgs-7	17(a) 10(a)	possible ortholog 1 ↔ many	II(12667632-12671556) X(3542545-3557581)

ENSEMBL Gene Tree for RGS3 (if available)
TreeFam Gene Tree for RGS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RGS3 gene

RGS2² RGS8² RGS19² RGS21² RGS16² RGS20² RGS5² RGS17²

RGS1² RGS18² RGS4² RGS13²

18/20 SIMAP similar genes for RGS3 using alignment to 12 protein entries: RGS3_HUMAN (see all proteins) (see all similar genes):

RGS4 RGS8 RGS2 RGS21 RGS5 RGS13

RGS16 RGS18 RGS20 RGS6 RGS10 RGS17

RGS19 RGS1 RGS11 RGS7 RGS12 RGS9

RGS3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56162944^1,2	C	--	85812855(+)	`TTTAAA/GAAATT`	1	--	us2k¹		0	--	--	--	--
rs79265136^1,2	C,F,	--	85814752(+)	`CCAGTT/GTGACA`	1	--	int¹		1		NA	120
rs55789227^1,2	C	--	85814757(+)	`TTGACA/GCCTGT`	1	--	int¹		0	--	--	--	--
rs861021^1,2	F	--	85814958(+)	`gctcaC/Ttgcaa`	1	--	int¹		1		MN	184
rs76080150^1,2		--	85815341(+)	`AATGAG/TTAGAA`	1	--	int¹		0	--	--	--	--
rs75008942^1,2	F,	--	85815662(+)	`AAAATG/CACATG`	1	--	int¹		1		EA	120
rs12000858^1,2	C,A,H,	--	85816527(+)	`tgtatA/Gtatat`	1	--	int¹		0	--	--	--	--
rs1771222^1,2	C,H	--	85816533(-)	`atataC/Tatata`	1	--	int¹		1		NA	2
rs77755719^1,2	F,	--	85817674(+)	`TTCGAC/ATTCTT`	1	--	int¹		1		WA	118
rs111815957^1,2	C,F,	--	85817860(+)	`GACTGA/GCTTCT`	1	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for RGS3 (116207011 - 116360018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RGS3
2 Indels: 29042 13196

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RGS3 for disorders           About GeneDecksing

OMIM gene information: 602189    OMIM disorders: --

9 diseases for RGS3:    About MalaCards

sick building syndrome cystic fibrosis squamous cell carcinoma fibrosis

pertussis breast cancer carcinoma pancreatitis

neuronitis

1 disease from the University of Copenhagen DISEASES database for RGS3:

Sick building syndrome

1 Novoseek disease relationship for RGS3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heart failure	0	2	11428836 (2)

Human Genome Epidemiology (HuGE) Navigator: RGS3 (4 documents)

Export disorders for RGS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RGS3 gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with RGS3)

Utopia: connect your pdf to the dynamic
world of online information

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PubMed id 8602223)^{1, 2, 3} Druey K.M.... Kehrl J.H. (1996)
RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. (PubMed id 9858594)^{1, 2, 9} Dulin N.O.... Dunn M.J. (1999)
Regulator of G-protein signaling 3 (RGS3) inhibits G-beta1/gamma2- induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation. (PubMed id 11294858)^{1, 2, 9} Shi C.-S....Kehrl J.H. (2001)
Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. (PubMed id 10749886)^{1, 2, 9} Dulin N.O....Dunn M.J. (2000)
Identification and Herc5-mediated ISGylation of novel target proteins. (PubMed id 16884686)^{1, 2} Takeuchi T....Yokosawa H. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3. (PubMed id 12036301)^{1, 2} Kehrl J.H.... Shi C.S. (2002)
C2PA, a new protein expressed during mouse spermatogenesis. (PubMed id 11034339)^{1, 3} Linares J.L....Rio M.C. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5998	HGNC: 9999	AceView: RGS3	Ensembl:ENSG00000138835	euGenes: HUgn5998
ECgene: RGS3	Kegg: 5998	H-InvDB: RGS3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RGS3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RGS3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RGS3 gene
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Patent Information for RGS3 gene:
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GeneCards and IP:
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regulator of G-protein signaling 3

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RGS3 Gene

regulator of G-protein signaling 3

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