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Aliases for RGS3 Gene

Aliases for RGS3 Gene

  • Regulator Of G-Protein Signaling 3 2 3
  • Regulator Of G-Protein Signalling 3 2 3
  • RGP3 3 4
  • C2PA 3

External Ids for RGS3 Gene

Previous GeneCards Identifiers for RGS3 Gene

  • GC09P107022
  • GC09P107956
  • GC09P109678
  • GC09P111600
  • GC09P113303
  • GC09P115262
  • GC09P116207
  • GC09P085814

Summaries for RGS3 Gene

Entrez Gene Summary for RGS3 Gene

  • This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

GeneCards Summary for RGS3 Gene

RGS3 (Regulator Of G-Protein Signaling 3) is a Protein Coding gene. Diseases associated with RGS3 include sick building syndrome. Among its related pathways are Activation of cAMP-Dependent PKA and Ephrin B reverse signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS3 Gene

  • Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

Gene Wiki entry for RGS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS3 Gene

Genomics for RGS3 Gene

Regulatory Elements for RGS3 Gene

Genomic Location for RGS3 Gene

Start:
113,444,729 bp from pter
End:
113,597,743 bp from pter
Size:
153,015 bases
Orientation:
Plus strand

Genomic View for RGS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS3 Gene

Proteins for RGS3 Gene

  • Protein details for RGS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49796-RGS3_HUMAN
    Recommended name:
    Regulator of G-protein signaling 3
    Protein Accession:
    P49796
    Secondary Accessions:
    • A6NHA0
    • A8K0V1
    • B3KUB2
    • Q5VXB8
    • Q5VXC1
    • Q5VZ05
    • Q5VZ06
    • Q6ZRM5
    • Q8IUQ1
    • Q8NC47
    • Q8NFN4
    • Q8NFN5
    • Q8NFN6
    • Q8TD59
    • Q8TD68
    • Q8WV02
    • Q8WXA0

    Protein attributes for RGS3 Gene

    Size:
    1198 amino acids
    Molecular mass:
    132336 Da
    Quaternary structure:
    • Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.

    Three dimensional structures from OCA and Proteopedia for RGS3 Gene

    Alternative splice isoforms for RGS3 Gene

neXtProt entry for RGS3 Gene

Proteomics data for RGS3 Gene at MOPED

Post-translational modifications for RGS3 Gene

No data available for DME Specific Peptides for RGS3 Gene

Domains for RGS3 Gene

Gene Families for RGS3 Gene

HGNC:
  • RGS :Regulators of G-protein signaling

Graphical View of Domain Structure for InterPro Entry

P49796

UniProtKB/Swiss-Prot:

RGS3_HUMAN :
  • P49796
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS3: view

Function for RGS3 Gene

Molecular function for RGS3 Gene

GENATLAS Biochemistry: negative regulator of G protein signaling 3,functioning as GTPase-activating protein for G protein alpha i and q subunits,expressed in heart,skeletal muscle,lung and other tissues,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

Gene Ontology (GO) - Molecular Function for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RGS3: view

Phenotypes for RGS3 Gene

genes like me logo Genes that share phenotypes with RGS3: view

Animal Model Products

CRISPR Products

miRNA for RGS3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGS3 Gene

Localization for RGS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS3 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS3 Gene COMPARTMENTS Subcellular localization image for RGS3 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS 9858594
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS3: view

Pathways for RGS3 Gene

genes like me logo Genes that share pathways with RGS3: view

Gene Ontology (GO) - Biological Process for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8602223
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9858594
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity TAS 9858594
genes like me logo Genes that share ontologies with RGS3: view

Compounds for RGS3 Gene

(3) Novoseek inferred chemical compound relationships for RGS3 Gene

Compound -log(P) Hits PubMed IDs
gtp 42.4 1
gnrh 32.5 6
calcium 17.9 10
genes like me logo Genes that share compounds with RGS3: view

Transcripts for RGS3 Gene

Unigene Clusters for RGS3 Gene

Regulator of G-protein signaling 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^
SP1: - - - - - - -
SP2: - - - -
SP3: -
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ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e ^ 28a · 28b ^ 29a · 29b · 29c · 29d · 29e ^ 30a · 30b · 30c ^ 31a · 31b · 31c ^ 32 ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - -
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SP25: -
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SP32: - - - -
SP33: -
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SP37: - - - - - - - - - - - - - -
SP38:

ExUns: 33a · 33b · 33c · 33d · 33e · 33f ^ 34a · 34b · 34c · 34d · 34e · 34f · 34g · 34h · 34i · 34j · 34k · 34l ^ 35a · 35b ^ 36 ^ 37a · 37b · 37c · 37d · 37e ^
SP1:
SP2: - - - - - - - - - - - - - - - - - - - - - - - - -
SP3:
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SP17: - -
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SP37: - - - - - -
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ExUns: 38a · 38b ^ 39a · 39b ^ 40a · 40b · 40c ^ 41a · 41b · 41c · 41d ·
SP1:
SP2: - - -
SP3:
SP4: - - -
SP5:
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SP7: - - -
SP8: - - -
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SP16: - - -
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SP34:
SP35: -
SP36:
SP37:
SP38:

Relevant External Links for RGS3 Gene

GeneLoc Exon Structure for
RGS3
ECgene alternative splicing isoforms for
RGS3

Expression for RGS3 Gene

mRNA expression in normal human tissues for RGS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGS3 Gene

SOURCE GeneReport for Unigene cluster for RGS3 Gene Hs.494875

genes like me logo Genes that share expressions with RGS3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RGS3 Gene

Orthologs for RGS3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS3 35
  • 99.42 (n)
  • 99.58 (a)
RGS3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS3 35
  • 87.93 (n)
  • 86.88 (a)
RGS3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs3 35
  • 83.52 (n)
  • 84.12 (a)
Rgs3 16
Rgs3 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS3 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS3 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs3 35
  • 83.95 (n)
  • 83.46 (a)
chicken
(Gallus gallus)
Aves RGS3 35
  • 73.91 (n)
  • 72.62 (a)
RGS3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS3 36
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RGS3 36
  • 41 (a)
OneToOne
si:ch211-154e10.1 35
  • 59.98 (n)
  • 50.95 (a)
Species with no ortholog for RGS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS3 Gene

ENSEMBL:
Gene Tree for RGS3 (if available)
TreeFam:
Gene Tree for RGS3 (if available)

Paralogs for RGS3 Gene

Paralogs for RGS3 Gene

genes like me logo Genes that share paralogs with RGS3: view

Variants for RGS3 Gene

Sequence variations from dbSNP and Humsavar for RGS3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs11703 -- 113,597,637(+) CTGGG(G/T)GGAGT utr-variant-3-prime
rs861021 -- 113,445,754(+) gctca(C/T)tgcaa intron-variant
rs863671 -- 113,449,766(+) gagac(A/G)gagtc intron-variant
rs864217 -- 113,449,811(+) agtct(C/T)ggctc intron-variant
rs864688 -- 113,449,845(+) tcaag(C/T)gattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS3 Gene

Variant ID Type Subtype PubMed ID
nsv893747 CNV Loss 21882294
esv1750461 CNV Deletion 17803354
esv2738955 CNV Deletion 23290073
nsv415849 CNV Loss 16902084
nsv466508 CNV Loss 19166990
nsv526579 CNV Loss 19592680
nsv893748 CNV Gain 21882294

Relevant External Links for RGS3 Gene

HapMap Linkage Disequilibrium report
RGS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS3 Gene

Disorders for RGS3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RGS3 Gene including...

Search for RGS3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RGS3 Gene

(1) Novoseek inferred disease relationships for RGS3 Gene

Disease -log(P) Hits PubMed IDs
heart failure 0 2

Relevant External Links for RGS3

Genetic Association Database (GAD)
RGS3
Human Genome Epidemiology (HuGE) Navigator
RGS3
genes like me logo Genes that share disorders with RGS3: view

No data available for UniProtKB/Swiss-Prot for RGS3 Gene

Publications for RGS3 Gene

  1. Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. (PMID: 10749886) Dulin N.O. … Dunn M.J. (J. Biol. Chem. 2000) 3 4 23
  2. Regulator of G-protein signaling 3 (RGS3) inhibits G-beta1/gamma2- induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation. (PMID: 11294858) Shi C.-S. … Kehrl J.H. (J. Biol. Chem. 2001) 3 4 23
  3. RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. (PMID: 9858594) Dulin N.O. … Dunn M.J. (Mol. Cell. Biol. 1999) 3 4 23
  4. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PMID: 8602223) Druey K.M. … Kehrl J.H. (Nature 1996) 2 3 4
  5. Genomic assessment of follicular marker genes as pregnancy predictors for human IVF. (PMID: 19778949) Hamel M. … Sirard M.A. (Mol. Hum. Reprod. 2010) 3 23

Products for RGS3 Gene

Sources for RGS3 Gene

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