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Aliases for RGS3 Gene

Aliases for RGS3 Gene

  • Regulator Of G-Protein Signaling 3 2 3 5
  • Regulator Of G-Protein Signalling 3 2 3
  • RGP3 3 4
  • C2PA 3

External Ids for RGS3 Gene

Previous GeneCards Identifiers for RGS3 Gene

  • GC09P107022
  • GC09P107956
  • GC09P109678
  • GC09P111600
  • GC09P113303
  • GC09P115262
  • GC09P116207
  • GC09P085814
  • GC09P113448
  • GC09P113549

Summaries for RGS3 Gene

Entrez Gene Summary for RGS3 Gene

  • This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

GeneCards Summary for RGS3 Gene

RGS3 (Regulator Of G-Protein Signaling 3) is a Protein Coding gene. Among its related pathways are Axon guidance and EphB-EphrinB Signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS3 Gene

  • Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

Gene Wiki entry for RGS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS3 Gene

Genomics for RGS3 Gene

Regulatory Elements for RGS3 Gene

Enhancers for RGS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS3 Gene

Chromosome:
9
Start:
113,444,729 bp from pter
End:
113,597,743 bp from pter
Size:
153,015 bases
Orientation:
Plus strand

Genomic View for RGS3 Gene

Genes around RGS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS3 Gene

Proteins for RGS3 Gene

  • Protein details for RGS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49796-RGS3_HUMAN
    Recommended name:
    Regulator of G-protein signaling 3
    Protein Accession:
    P49796
    Secondary Accessions:
    • A6NHA0
    • A8K0V1
    • B3KUB2
    • Q5VXB8
    • Q5VXC1
    • Q5VZ05
    • Q5VZ06
    • Q6ZRM5
    • Q8IUQ1
    • Q8NC47
    • Q8NFN4
    • Q8NFN5
    • Q8NFN6
    • Q8TD59
    • Q8TD68
    • Q8WV02
    • Q8WXA0

    Protein attributes for RGS3 Gene

    Size:
    1198 amino acids
    Molecular mass:
    132336 Da
    Quaternary structure:
    • Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.

    Three dimensional structures from OCA and Proteopedia for RGS3 Gene

    Alternative splice isoforms for RGS3 Gene

neXtProt entry for RGS3 Gene

Proteomics data for RGS3 Gene at MOPED

Post-translational modifications for RGS3 Gene

No data available for DME Specific Peptides for RGS3 Gene

Domains & Families for RGS3 Gene

Graphical View of Domain Structure for InterPro Entry

P49796

UniProtKB/Swiss-Prot:

RGS3_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS3: view

Function for RGS3 Gene

Molecular function for RGS3 Gene

GENATLAS Biochemistry:
negative regulator of G protein signaling 3,functioning as GTPase-activating protein for G protein alpha i and q subunits,expressed in heart,skeletal muscle,lung and other tissues,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

Gene Ontology (GO) - Molecular Function for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 9858594
genes like me logo Genes that share ontologies with RGS3: view
genes like me logo Genes that share phenotypes with RGS3: view

miRNA for RGS3 Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS3 Gene

Localization for RGS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS3 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS3 Gene COMPARTMENTS Subcellular localization image for RGS3 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RGS3: view

Pathways & Interactions for RGS3 Gene

genes like me logo Genes that share pathways with RGS3: view

Gene Ontology (GO) - Biological Process for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8602223
genes like me logo Genes that share ontologies with RGS3: view

No data available for SIGNOR curated interactions for RGS3 Gene

Drugs & Compounds for RGS3 Gene

(1) Drugs for RGS3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RGS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS3: view

Transcripts for RGS3 Gene

Unigene Clusters for RGS3 Gene

Regulator of G-protein signaling 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^
SP1: - - - - - - -
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ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e ^ 28a · 28b ^ 29a · 29b · 29c · 29d · 29e ^ 30a · 30b · 30c ^ 31a · 31b · 31c ^ 32 ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - -
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SP33: -
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SP37: - - - - - - - - - - - - - -
SP38:

ExUns: 33a · 33b · 33c · 33d · 33e · 33f ^ 34a · 34b · 34c · 34d · 34e · 34f · 34g · 34h · 34i · 34j · 34k · 34l ^ 35a · 35b ^ 36 ^ 37a · 37b · 37c · 37d · 37e ^
SP1:
SP2: - - - - - - - - - - - - - - - - - - - - - - - - -
SP3:
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SP5: - - - - - -
SP6: - - - - - -
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SP14: - - - - - -
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SP16: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP17: - -
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SP20: - - - - - -
SP21: - -
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SP24: - -
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ExUns: 38a · 38b ^ 39a · 39b ^ 40a · 40b · 40c ^ 41a · 41b · 41c · 41d ·
SP1:
SP2: - - -
SP3:
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SP5:
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SP7: - - -
SP8: - - -
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SP16: - - -
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SP35: -
SP36:
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SP38:

Relevant External Links for RGS3 Gene

GeneLoc Exon Structure for
RGS3
ECgene alternative splicing isoforms for
RGS3

Expression for RGS3 Gene

mRNA expression in normal human tissues for RGS3 Gene

Protein differential expression in normal tissues from HIPED for RGS3 Gene

This gene is overexpressed in NK cells (24.7), Peripheral blood mononuclear cells (17.3), and CD8 Tcells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGS3 Gene



SOURCE GeneReport for Unigene cluster for RGS3 Gene Hs.494875

genes like me logo Genes that share expression patterns with RGS3: view

Protein tissue co-expression partners for RGS3 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RGS3 Gene

Orthologs for RGS3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS3 35
  • 87.93 (n)
  • 86.88 (a)
RGS3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs3 35
  • 83.52 (n)
  • 84.12 (a)
Rgs3 16
Rgs3 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS3 35
  • 99.42 (n)
  • 99.58 (a)
RGS3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs3 35
  • 83.95 (n)
  • 83.46 (a)
dog
(Canis familiaris)
Mammalia RGS3 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS3 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS3 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS3 35
  • 73.91 (n)
  • 72.62 (a)
RGS3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS3 36
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-154e10.1 35
  • 59.98 (n)
  • 50.95 (a)
RGS3 36
  • 41 (a)
OneToOne
Species with no ortholog for RGS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS3 Gene

ENSEMBL:
Gene Tree for RGS3 (if available)
TreeFam:
Gene Tree for RGS3 (if available)

Paralogs for RGS3 Gene

Paralogs for RGS3 Gene

genes like me logo Genes that share paralogs with RGS3: view

Variants for RGS3 Gene

Sequence variations from dbSNP and Humsavar for RGS3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs16933949 - 113,462,172(+) GAAGA(A/G)GATCA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs41305473 - 113,583,838(+) CACCC(A/G)GGACC intron-variant, downstream-variant-500B, reference, missense
rs861021 -- 113,445,754(+) gctca(C/T)tgcaa intron-variant
rs863671 -- 113,449,766(+) gagac(A/G)gagtc intron-variant
rs864217 -- 113,449,811(+) agtct(C/T)ggctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS3 Gene

Variant ID Type Subtype PubMed ID
nsv893747 CNV Loss 21882294
esv1750461 CNV Deletion 17803354
esv2738955 CNV Deletion 23290073
nsv415849 CNV Loss 16902084
nsv466508 CNV Loss 19166990
nsv526579 CNV Loss 19592680
nsv893748 CNV Gain 21882294

Variation tolerance for RGS3 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RGS3 Gene

Disorders for RGS3 Gene

Relevant External Links for RGS3

Genetic Association Database (GAD)
RGS3
Human Genome Epidemiology (HuGE) Navigator
RGS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS3

No disorders were found for RGS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS3 Gene

Publications for RGS3 Gene

  1. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PMID: 8602223) Druey K.M. … Kehrl J.H. (Nature 1996) 2 3 4 67
  2. Genomic assessment of follicular marker genes as pregnancy predictors for human IVF. (PMID: 19778949) Hamel M. … Sirard M.A. (Mol. Hum. Reprod. 2010) 3 23
  3. 14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3). (PMID: 20347994) Rezabkova L. … Obsil T. (J. Struct. Biol. 2010) 3 23
  4. Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase. (PMID: 19333232) Nishiura H. … Yamamoto T. (Lab. Invest. 2009) 3 23
  5. Regulation of Smad-mediated gene transcription by RGS3. (PMID: 18287247) Yau D.M. … Dulin N.O. (Mol. Pharmacol. 2008) 3 23

Products for RGS3 Gene

Sources for RGS3 Gene

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