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Aliases for RGS22 Gene

Aliases for RGS22 Gene

  • Regulator Of G Protein Signaling 22 2 3
  • Regulator Of G-Protein Signaling 22 2 3 5
  • Regulator Of G-Protein Signalling 22 2
  • PRTD-NY2 3
  • CT145 3

External Ids for RGS22 Gene

Previous GeneCards Identifiers for RGS22 Gene

  • GC08M101044
  • GC08M096176
  • GC08M100973

Summaries for RGS22 Gene

GeneCards Summary for RGS22 Gene

RGS22 (Regulator Of G Protein Signaling 22) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity.

UniProtKB/Swiss-Prot for RGS22 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS22 Gene

Genomics for RGS22 Gene

Regulatory Elements for RGS22 Gene

Enhancers for RGS22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G100487 2 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -364.1 -364105 16.6 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A YBX1 ZBTB7B YY1 RNF19A SPAG1 ENSG00000202310 ANKRD46 ENSG00000253217 ENSG00000261087 RGS22 ENSG00000254364 YWHAZ GC08M100535
GH08G100441 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -312.5 -312549 5.2 HDGF TBP FOXA2 NFIB WRNIP1 YBX1 RAD21 KAT2B YY1 ZNF366 RNF19A ENSG00000253666 ENSG00000253217 ANKRD46 RGS22 SPAG1 PABPC1 GC08M100437 GC08M100448
GH08G100525 1.5 Ensembl ENCODE dbSUPER 10.3 -396.7 -396659 4.5 HDGF PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B SIN3A YY1 ZNF143 ANKRD46 POLR2K FBXO43 ENSG00000253666 ENSG00000202310 SPAG1 ENSG00000253217 RNF19A RGS22 LOC105375674
GH08G100507 1.5 Ensembl ENCODE dbSUPER 9.9 -379.4 -379377 5.5 PKNOX1 ATF1 FOXA2 SIN3A FEZF1 GLIS2 FOS ZHX2 REST GLIS1 ENSG00000253666 ENSG00000202310 SPAG1 RGS22 LOC105375674 ENSG00000254364 GC08M100535
GH08G100481 1.5 Ensembl ENCODE dbSUPER 9.2 -351.3 -351299 2.5 FOXA2 ZFP64 WRNIP1 SIN3A ELK1 PPARG ZNF592 SREBF1 SSRP1 MIER3 ENSG00000202310 SPAG1 ANKRD46 RGS22 ENSG00000254364 ENSG00000253666
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGS22 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS22 Gene

Chromosome:
8
Start:
99,960,936 bp from pter
End:
100,131,268 bp from pter
Size:
170,333 bases
Orientation:
Minus strand

Genomic View for RGS22 Gene

Genes around RGS22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS22 Gene

Proteins for RGS22 Gene

  • Protein details for RGS22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE09-RGS22_HUMAN
    Recommended name:
    Regulator of G-protein signaling 22
    Protein Accession:
    Q8NE09
    Secondary Accessions:
    • A8K944
    • Q569L2
    • Q86Y71
    • Q9BYZ4
    • Q9UFN6

    Protein attributes for RGS22 Gene

    Size:
    1264 amino acids
    Molecular mass:
    147163 Da
    Quaternary structure:
    • Interacts with GNA11, GNA12 AND GNA13.
    SequenceCaution:
    • Sequence=AAG49397.1; Type=Frameshift; Positions=877, 882, 886, 891; Evidence={ECO:0000305};

    Alternative splice isoforms for RGS22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS22 Gene

Post-translational modifications for RGS22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS22 Gene

Domains & Families for RGS22 Gene

Gene Families for RGS22 Gene

Protein Domains for RGS22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGS22 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS22: view

No data available for UniProtKB/Swiss-Prot for RGS22 Gene

Function for RGS22 Gene

Molecular function for RGS22 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Gene Ontology (GO) - Molecular Function for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RGS22: view
genes like me logo Genes that share phenotypes with RGS22: view

Animal Model Products

CRISPR Products

miRNA for RGS22 Gene

miRTarBase miRNAs that target RGS22

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS22 Gene

Localization for RGS22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS22 Gene

Cytoplasm. Nucleus. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS22 gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS22: view

Pathways & Interactions for RGS22 Gene

genes like me logo Genes that share pathways with RGS22: view

Pathways by source for RGS22 Gene

Interacting Proteins for RGS22 Gene

Gene Ontology (GO) - Biological Process for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS22: view

No data available for SIGNOR curated interactions for RGS22 Gene

Transcripts for RGS22 Gene

Unigene Clusters for RGS22 Gene

Regulator of G-protein signaling 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS22 Gene

No ASD Table

Relevant External Links for RGS22 Gene

GeneLoc Exon Structure for
RGS22
ECgene alternative splicing isoforms for
RGS22

Expression for RGS22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS22 Gene

mRNA differential expression in normal tissues according to GTEx for RGS22 Gene

This gene is overexpressed in Testis (x26.8) and Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for RGS22 Gene

This gene is overexpressed in Breast (42.6), Tlymphocyte (13.0), and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS22 Gene



Protein tissue co-expression partners for RGS22 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS22 Gene:

RGS22

SOURCE GeneReport for Unigene cluster for RGS22 Gene:

Hs.120021

mRNA Expression by UniProt/SwissProt for RGS22 Gene:

Q8NE09-RGS22_HUMAN
Tissue specificity: Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level).
genes like me logo Genes that share expression patterns with RGS22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS22 Gene

Orthologs for RGS22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS22 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia RGS22 34 35
  • 88.25 (n)
cow
(Bos Taurus)
Mammalia RGS22 34 35
  • 87.77 (n)
mouse
(Mus musculus)
Mammalia Rgs22 34 16 35
  • 79.73 (n)
rat
(Rattus norvegicus)
Mammalia Rgs22 34
  • 79.44 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS22 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS22 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS22 34 35
  • 64.93 (n)
lizard
(Anolis carolinensis)
Reptilia RGS22 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs22 34
  • 59.24 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884083 34
  • 49.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for RGS22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS22 Gene

ENSEMBL:
Gene Tree for RGS22 (if available)
TreeFam:
Gene Tree for RGS22 (if available)

Paralogs for RGS22 Gene

No data available for Paralogs for RGS22 Gene

Variants for RGS22 Gene

Sequence variations from dbSNP and Humsavar for RGS22 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000033630 -- 99,985,618(+) ATAAT(-/AAC)ATTTG intron-variant
rs1000041795 -- 100,047,084(+) TGCTG(C/T)GATTA intron-variant
rs1000095899 -- 100,000,920(+) TGCCT(C/T)ACTTG intron-variant
rs1000144869 -- 99,993,932(+) CTGCT(C/T)CATCC intron-variant
rs1000193355 -- 100,019,552(+) CCTAT(A/G/T)TACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS22 Gene

Variant ID Type Subtype PubMed ID
esv1068346 CNV deletion 17803354
esv1205143 CNV deletion 17803354
esv2466799 CNV deletion 19546169
esv3618185 CNV loss 21293372
nsv1030482 CNV loss 25217958
nsv1077059 CNV deletion 25765185
nsv396616 CNV deletion 16902084
nsv611814 CNV loss 21841781
nsv967622 CNV duplication 23825009

Variation tolerance for RGS22 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS22 Gene

Disorders for RGS22 Gene

Relevant External Links for RGS22

Genetic Association Database (GAD)
RGS22
Human Genome Epidemiology (HuGE) Navigator
RGS22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS22

No disorders were found for RGS22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS22 Gene

Publications for RGS22 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J. … Wu X. (Carcinogenesis 2010) 3 46 64
  3. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. (PMID: 18703424) Hu Y. … Sha J. (Biol. Reprod. 2008) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RGS22 Gene

Sources for RGS22 Gene

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