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Aliases for RGS22 Gene

Aliases for RGS22 Gene

  • Regulator Of G-Protein Signaling 22 2 3 5
  • Regulator Of G-Protein Signalling 22 2
  • PRTD-NY2 3
  • CT145 3

External Ids for RGS22 Gene

Previous GeneCards Identifiers for RGS22 Gene

  • GC08M101044
  • GC08M096176
  • GC08M100973

Summaries for RGS22 Gene

GeneCards Summary for RGS22 Gene

RGS22 (Regulator Of G-Protein Signaling 22) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase activator activity.

UniProtKB/Swiss-Prot for RGS22 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS22 Gene

Genomics for RGS22 Gene

Regulatory Elements for RGS22 Gene

Enhancers for RGS22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F100487 1.8 FANTOM5 Ensembl ENCODE 9.7 -364.1 -364105 16.6 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A YBX1 YY1 SLC30A9 ZNF207 RNF19A SPAG1 POLR2K ENSG00000202310 ANKRD46 ENSG00000253217 ENSG00000271882 RGS22 ENSG00000254364 YWHAZ
GH08F100441 1.5 FANTOM5 Ensembl ENCODE 9.2 -312.5 -312549 5.2 HDGF TBP WRNIP1 YBX1 RAD21 YY1 KAT2B ZNF366 FOS MIXL1 RNF19A ENSG00000253666 ENSG00000253217 ANKRD46 RGS22 SPAG1 PABPC1 GC08M100437 GC08M100448
GH08F100525 1.3 Ensembl ENCODE 10.3 -396.7 -396659 4.5 HDGF PKNOX1 ATF1 MLX ZFP64 ARID4B SIN3A YY1 ZNF143 FOS ANKRD46 FBXO43 POLR2K ENSG00000253666 ENSG00000202310 SPAG1 ENSG00000253217 RNF19A RGS22 LOC105375674
GH08F100507 1.2 Ensembl ENCODE 9.9 -379.4 -379377 5.5 TBP HDGF ATF1 PKNOX1 SIN3A FEZF1 ZBTB40 RAD21 RFX5 GLIS2 ENSG00000253666 ENSG00000202310 SPAG1 RGS22 LOC105375674 ENSG00000254364 GC08M100535
GH08F100428 1.1 Ensembl ENCODE 10.1 -297.8 -297823 1.0 IRF2 MXI1 SIN3A YY1 ZKSCAN1 RELA EGR1 FOXK2 EED ETV6 ENSG00000253666 ENSG00000253217 RNF19A ENSG00000202310 SPAG1 RGS22 ENSG00000253842 ENSG00000253824
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGS22 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS22 Gene

99,960,936 bp from pter
100,131,268 bp from pter
170,333 bases
Minus strand

Genomic View for RGS22 Gene

Genes around RGS22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS22 Gene

Proteins for RGS22 Gene

  • Protein details for RGS22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 22
    Protein Accession:
    Secondary Accessions:
    • A8K944
    • Q569L2
    • Q86Y71
    • Q9BYZ4
    • Q9UFN6

    Protein attributes for RGS22 Gene

    1264 amino acids
    Molecular mass:
    147163 Da
    Quaternary structure:
    • Interacts with GNA11, GNA12 AND GNA13.
    • Sequence=AAG49397.1; Type=Frameshift; Positions=877, 882, 886, 891; Evidence={ECO:0000305};

    Alternative splice isoforms for RGS22 Gene


neXtProt entry for RGS22 Gene

Post-translational modifications for RGS22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS22 Gene

Domains & Families for RGS22 Gene

Gene Families for RGS22 Gene

Protein Domains for RGS22 Gene


Suggested Antigen Peptide Sequences for RGS22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RGS domains.
  • Contains 2 RGS domains.
genes like me logo Genes that share domains with RGS22: view

Function for RGS22 Gene

Molecular function for RGS22 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Gene Ontology (GO) - Molecular Function for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RGS22: view
genes like me logo Genes that share phenotypes with RGS22: view

Animal Model Products

miRNA for RGS22 Gene

miRTarBase miRNAs that target RGS22

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS22 Gene

Localization for RGS22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS22 Gene

Cytoplasm. Nucleus. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS22 gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS22: view

Pathways & Interactions for RGS22 Gene

genes like me logo Genes that share pathways with RGS22: view

Pathways by source for RGS22 Gene

Interacting Proteins for RGS22 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000354109 Q8NE09-RGS22_HUMAN for RGS22 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS22: view

No data available for SIGNOR curated interactions for RGS22 Gene

Transcripts for RGS22 Gene

Unigene Clusters for RGS22 Gene

Regulator of G-protein signaling 22:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS22 Gene

No ASD Table

Relevant External Links for RGS22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS22 Gene

mRNA differential expression in normal tissues according to GTEx for RGS22 Gene

This gene is overexpressed in Testis (x26.8) and Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for RGS22 Gene

This gene is overexpressed in Breast (42.6), Tlymphocyte (13.0), and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS22 Gene

Protein tissue co-expression partners for RGS22 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS22 Gene:


SOURCE GeneReport for Unigene cluster for RGS22 Gene:


mRNA Expression by UniProt/SwissProt for RGS22 Gene:

Tissue specificity: Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level).
genes like me logo Genes that share expression patterns with RGS22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RGS22 Gene

Orthologs for RGS22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS22 34 35
  • 99.68 (n)
(Canis familiaris)
Mammalia RGS22 34 35
  • 88.25 (n)
(Bos Taurus)
Mammalia RGS22 34 35
  • 87.77 (n)
(Mus musculus)
Mammalia Rgs22 34 16 35
  • 79.73 (n)
(Rattus norvegicus)
Mammalia Rgs22 34
  • 79.44 (n)
(Monodelphis domestica)
Mammalia RGS22 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia RGS22 35
  • 61 (a)
(Gallus gallus)
Aves RGS22 34 35
  • 64.93 (n)
(Anolis carolinensis)
Reptilia RGS22 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs22 34
  • 59.24 (n)
(Danio rerio)
Actinopterygii LOC101884083 34
  • 49.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
Species where no ortholog for RGS22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS22 Gene

Gene Tree for RGS22 (if available)
Gene Tree for RGS22 (if available)

Paralogs for RGS22 Gene

No data available for Paralogs for RGS22 Gene

Variants for RGS22 Gene

Sequence variations from dbSNP and Humsavar for RGS22 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10046693 -- 100,019,971(+) cctcc(A/G)tctcc intron-variant
rs10088789 -- 100,090,901(+) gtccc(C/T)agaca intron-variant
rs10091391 -- 100,016,187(+) CTCAG(A/T)CATAT intron-variant
rs10099237 -- 100,049,910(+) caggc(C/G)tggtg intron-variant
rs10104624 -- 100,046,085(+) tctaa(C/G)atatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS22 Gene

Variant ID Type Subtype PubMed ID
nsv967622 CNV duplication 23825009
nsv611814 CNV loss 21841781
nsv396616 CNV deletion 16902084
nsv1077059 CNV deletion 25765185
nsv1030482 CNV loss 25217958
esv3618185 CNV loss 21293372
esv2466799 CNV deletion 19546169
esv1205143 CNV deletion 17803354
esv1068346 CNV deletion 17803354

Variation tolerance for RGS22 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS22 Gene

Disorders for RGS22 Gene

Relevant External Links for RGS22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGS22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS22 Gene

Publications for RGS22 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J. … Wu X. (Carcinogenesis 2010) 3 46 64
  3. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. (PMID: 18703424) Hu Y. … Sha J. (Biol. Reprod. 2008) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RGS22 Gene

Sources for RGS22 Gene

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