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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGS22 Gene

protein-coding GIFtS: 47
GCID: GC08M100973

regulator of G-protein signaling 22

(Previous name: regulator of G-protein signalling 22 )

Explore 3 diseases affiliated with
RGS22 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 22¹ ²
PRTD-NY2¹ ²
DKFZP434I092¹
Regulator Of G-Protein Signalling 22¹

External Ids:	HGNC: 24499¹	Entrez Gene: 26166²	Ensembl: ENSG00000132554⁷	UniProtKB: Q8NE09³

Export aliases for RGS22 gene to outside databases

Previous GC identifers: GC08M101044 GC08M096176

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RGS22_HUMAN, Q8NE09

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGS22 gene promoter:
TBP Pbx1a HNF-3beta Tal-1beta C/EBPalpha MEF-2A aMEF-2 ITF-2 En-1 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS22 promoter sequence

Search SABiosciences Chromatin IP Primers for RGS22

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS22

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2 Ensembl cytogenetic band: 8q22.2 HGNC cytogenetic band: 8q22.2

RGS22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS22 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M100973: view genomic region (about GC identifiers)

Start:	100,973,164 bp from pter	End:	101,143,496 bp from pter
Size:	170,333 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGS22_HUMAN, Q8NE09 (See protein sequence)

Recommended Name: Regulator of G-protein signaling 22

Size: 1264 amino acids; 147163 Da

Secondary accessions: Q569L2 Q86Y71 Q9UFN6

Alternative splicing: 2 isoforms: Q8NE09-1 Q8NE09-2 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RGS22: NX_Q8NE09

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NE09

RGS22 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056483.3

ENSEMBL proteins:

ENSP00000354109 ENSP00000429382 ENSP00000430378 ENSP00000428212 ENSP00000427754

ENSP00000427798 ENSP00000429198 ENSP00000430903 ENSP00000427930

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	Uscn Proteins for RGS22

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IBA	--
GO:0005886	plasma membrane	IBA	--

RGS22 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGS22 for domains About GeneDecksing

2 InterPro domains/families:

IPR000342 Regulat_G_prot_signal

IPR016137 Regulat_G_prot_signal_superfam

Graphical View of Domain Structure for InterPro Entry Q8NE09

ProtoNet protein and cluster: Q8NE09

UniProtKB/Swiss-Prot: RGS22_HUMAN, Q8NE09

Similarity: Contains 2 RGS domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RGS22_HUMAN, Q8NE09

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form (By similarity)

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IBA	--

RGS22 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RGS22:

Synthetic lethal with Ras

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RGS22

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for RGS22 (Q8NE09³ ENSP00000354109⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3GLB2	Q9NR46³	I2D: score=1
GSK3B	ENSP00000324806⁴	STRING: ENSP00000324806

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0038032	termination of G-protein coupled receptor signaling pathway	IEA	--
GO:0043547	positive regulation of GTPase activity	IBA	--

RGS22 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGS22
Search CenterWatch for drugs/clinical trials and news about RGS22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGS22 gene:

NM_015668.3

Unigene Cluster for RGS22:

Regulator of G-protein signaling 22

Hs.120021 [show with all ESTs]

Unigene Representative Sequence: BC092411

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000360863(uc011lgz.1 uc003yjb.1 uc003yjc.1 uc010mbo.1)

ENST00000523287(uc003yja.1) ENST00000517769(uc022azf.1) ENST00000517843

ENST00000523437 ENST00000517828 ENST00000519421 ENST00000519725 ENST00000520923(uc022azh.1)

ENST00000518474 ENST00000524182 ENST00000520117 ENST00000519092 ENST00000519408

ENST00000522064 ENST00000523600 ENST00000518719

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Additional cDNA sequence:

AK097399.1 AK292559.1 AK302475.1 AK309194.1 AL117544.1 AY009106.1 BC036665.1 BC047060.1

BC050053.1 BC092411.1

8 DOTS entries:

DT.95312569 DT.409140 DT.95219709 DT.120636512 DT.95154354 DT.120636483 DT.120636502 DT.95236101

24/50 AceView cDNA sequences (see all 50):

BM929758 BC050053 BX101099 AI202895 AL043929 AI827862 AI911174 AI127752

AK097399 AW169431 BE463845 BI823859 BC047060 BC036665 AW072366 AI674775

BU680476 AI005136 AL117544 AL706377 AY009106 BG772468 AI808987 BI562612

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGS22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGCTCCA

About this image
See RGS22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGS22

SOURCE GeneReport for Unigene cluster: Hs.120021

SABiosciences Custom PCR Arrays for RGS22

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RGS22 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rgs22^{1 , 5}	regulator of G-protein signalling 22^{1, 5}	79.81(n)¹ 76.18(a)¹		15 (14.46 cM)⁵ 626596¹ NM_001195748.1¹ NP_001182677.1¹ 36009479⁵
chicken (Gallus gallus)	Aves	RGS22⁶	Uncharacterized protein	59(a)	1 ↔ 1	2(133428343-133439511)
lizard (Anolis carolinensis)	Reptilia	RGS22⁶	--	53(a)	1 ↔ 1	GL343394.1(335190-418815)
zebrafish (Danio rerio)	Actinopterygii	CU694952.3⁶ CU694952.2⁶	--	38(a) 33(a)	1 ↔ 1 possible ortholog	16(58156445-58158896) 16(58156445-58166227)

ENSEMBL Gene Tree for RGS22 (if available)
TreeFam Gene Tree for RGS22 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200992361^1,2	C,	other	101075809(+)	`CCCTGC/G/TTCTCT`	3	N T S	mis¹		0	--	--	--	--
rs150647546^1,2	C,	--	100972908(+)	`TCTCA-/AAT AATAATAATAA`	1	--	ds500¹		0	--	--	--	--
rs56289188^1,2	C	--	100972915(+)	`TAATA-/ATA ATAATATAGTT`	1	--	ds500¹		1		NA	2
rs73273301^1,2	C,F,	--	100973144(+)	`CTTAAT/CGACTG`	1	--	ds500¹		5		WA CSA NA EA	362
rs78665549^1,2		--	100973250(+)	`CAGAAC/TAGCTA`	1	--	ds500¹		1		CSA	2
rs73699896^1,2	C,F,	--	100973298(+)	`TCTTTA/CTTTAT`	1	--	ut3¹		3		WA CSA	122
rs186457818^1,2		--	100973406(+)	`AGCAGA/GATCTG`	1	--	ut3¹		0	--	--	--	--
rs191350203^1,2		--	100973465(+)	`ATCTAC/TAGAAA`	1	--	int¹		0	--	--	--	--
rs183662772^1,2		--	100973511(+)	`ACTTAC/TATAGA`	1	--	int¹		0	--	--	--	--
rs7015420^1,2	C,	--	100973549(+)	`cacccC/Aaatct`	1	--	int¹		1		CSA	2

HapMap Linkage Disequilibrium report for RGS22 (100973164 - 101143496 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RGS22
1 CNV: 100438

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS22

DNA2.0 Custom Variant and Variant Library Synthesis for RGS22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RGS22 for disorders About GeneDecksing

3 diseases for RGS22: About MalaCards

squamous cell carcinoma azoospermia carcinoma

1 disease from the University of Copenhagen DISEASES database for RGS22:

Azoospermia

Human Genome Epidemiology (HuGE) Navigator: RGS22 (2 documents)

Export disorders for RGS22 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RGS22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RGS22)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
RGS22, a novel cancer/testis antigen, inhibits epithe lial cell invasion and metastasis. (PubMed id 21533872)¹ Hu Y....Sha J. (2011)
Genetic variations in regulator of G-protein signalin g genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)¹ Wang J....Wu X. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. (PubMed id 18703424)¹ Hu Y....Sha J. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 26166	HGNC: 24499	AceView: DKFZP434I092	Ensembl:ENSG00000132554	euGenes: HUgn26166
ECgene: RGS22	H-InvDB: RGS22

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RGS22	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RGS22 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RGS22 gene:
Search GeneIP for patents involving RGS22

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RGS22 gene at Home site.

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RGS22 Gene

regulator of G-protein signaling 22

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RGS22 Gene

regulator of G-protein signaling 22

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