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Aliases for RGS21 Gene

Aliases for RGS21 Gene

  • Regulator Of G-Protein Signaling 21 2 3 5
  • Regulator Of G-Protein Signalling 21 2

External Ids for RGS21 Gene

Previous GeneCards Identifiers for RGS21 Gene

  • GC00U914493
  • GC01U901126
  • GC01P190552
  • GC01P163522

Summaries for RGS21 Gene

Entrez Gene Summary for RGS21 Gene

  • Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]

GeneCards Summary for RGS21 Gene

RGS21 (Regulator Of G-Protein Signaling 21) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS21 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS21 Gene

Genomics for RGS21 Gene

Regulatory Elements for RGS21 Gene

Enhancers for RGS21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGS21 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS21 Gene

192,316,992 bp from pter
192,367,285 bp from pter
50,294 bases
Plus strand

Genomic View for RGS21 Gene

Genes around RGS21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS21 Gene

Proteins for RGS21 Gene

  • Protein details for RGS21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 21
    Protein Accession:

    Protein attributes for RGS21 Gene

    152 amino acids
    Molecular mass:
    17671 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RGS21 Gene

Proteomics data for RGS21 Gene at MOPED

Post-translational modifications for RGS21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RGS21

No data available for DME Specific Peptides for RGS21 Gene

Domains & Families for RGS21 Gene

Gene Families for RGS21 Gene

Protein Domains for RGS21 Gene

Suggested Antigen Peptide Sequences for RGS21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RGS domain.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS21: view

Function for RGS21 Gene

Molecular function for RGS21 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Phenotypes for RGS21 Gene

GenomeRNAi human phenotypes for RGS21:
genes like me logo Genes that share phenotypes with RGS21: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGS21 Gene

Localization for RGS21 Gene

Subcellular locations from

Jensen Localization Image for RGS21 Gene COMPARTMENTS Subcellular localization image for RGS21 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RGS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RGS21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGS21 Gene

Pathways & Interactions for RGS21 Gene

genes like me logo Genes that share pathways with RGS21: view

Interacting Proteins for RGS21 Gene

Gene Ontology (GO) - Biological Process for RGS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RGS21: view

No data available for SIGNOR curated interactions for RGS21 Gene

Drugs & Compounds for RGS21 Gene

No Compound Related Data Available

Transcripts for RGS21 Gene

mRNA/cDNA for RGS21 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGS21 Gene

Regulator of G-protein signaling 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS21 Gene

No ASD Table

Relevant External Links for RGS21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS21 Gene

mRNA expression in normal human tissues for RGS21 Gene

Protein differential expression in normal tissues from HIPED for RGS21 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS21 Gene

SOURCE GeneReport for Unigene cluster for RGS21 Gene Hs.558673

mRNA Expression by UniProt/SwissProt for RGS21 Gene

Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with RGS21: view

Protein tissue co-expression partners for RGS21 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RGS21 Gene

Orthologs for RGS21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RGS21 35
  • 91.23 (n)
  • 88.16 (a)
RGS21 36
  • 85 (a)
(Canis familiaris)
Mammalia RGS21 35
  • 91.67 (n)
  • 92.11 (a)
RGS21 36
  • 89 (a)
(Mus musculus)
Mammalia Rgs21 35
  • 88.82 (n)
  • 87.5 (a)
Rgs21 16
Rgs21 36
  • 88 (a)
(Pan troglodytes)
Mammalia RGS21 35
  • 99.56 (n)
  • 99.34 (a)
RGS21 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC102551739 35
  • 88.82 (n)
  • 86.18 (a)
(Monodelphis domestica)
Mammalia RGS21 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia RGS21 36
  • 80 (a)
(Gallus gallus)
Aves RGS21 35
  • 72.37 (n)
  • 71.05 (a)
RGS21 36
  • 60 (a)
(Anolis carolinensis)
Reptilia RGS21 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs21 35
  • 67.26 (n)
  • 69.64 (a)
(Danio rerio)
Actinopterygii rgs1 35
  • 55.97 (n)
  • 49.25 (a)
rgs3b 36
  • 6 (a)
Species with no ortholog for RGS21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS21 Gene

Gene Tree for RGS21 (if available)
Gene Tree for RGS21 (if available)

Paralogs for RGS21 Gene

Paralogs for RGS21 Gene

(16) SIMAP similar genes for RGS21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS21: view

Variants for RGS21 Gene

Sequence variations from dbSNP and Humsavar for RGS21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1124172 -- 192,320,243(+) AAGTT(C/T)AACTA intron-variant
rs1416499 -- 192,324,237(+) GAAAC(A/G)AAGTT intron-variant
rs1416500 -- 192,334,338(+) TTACA(C/G)TCAAG intron-variant
rs1339130 -- 192,315,187(+) ATTAC(A/G)TTCAA upstream-variant-2KB
rs1339131 -- 192,320,836(+) CTTAA(A/G)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS21 Gene

Variant ID Type Subtype PubMed ID
dgv468n71 CNV Loss 21882294
esv271432 CNV Insertion 20981092

Variation tolerance for RGS21 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RGS21 Gene

Disorders for RGS21 Gene

Relevant External Links for RGS21

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGS21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS21 Gene

Publications for RGS21 Gene

  1. Isolation and expression pattern of RGS21 gene, a novel RGS member. (PMID: 16302027) Li X. … Mao Y. (Acta Biochim. Pol. 2005) 3 4 67
  2. RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. (PMID: 15066150) von Buchholtz L. … Conzelmann S. (Eur. J. Neurosci. 2004) 2 3
  3. Genome-wide linkage and association scans for pulse pressure in Chinese twins. (PMID: 22763476) Zhang D. … Tan Q. (Hypertens. Res. 2012) 3
  4. Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. (PMID: 23095746) Cohen S.P. … Kimple A.J. (J. Biol. Chem. 2012) 3

Products for RGS21 Gene

Sources for RGS21 Gene