RGS21 Gene
protein-coding GIFtS: 38
GCID: GC01P192286
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regulator of G-protein signaling 21(Previous name: regulator of G-protein signalling 21 )
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Aliases
for RGS21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regulator Of G-Protein Signaling 211 2 | | Regulator Of G-Protein Signalling 211 2 |
Export aliases for RGS21 gene to outside databasesPrevious GC identifers: GC00U914493 GC01U901126 GC01P190552 GC01P163522 |
Summaries
for RGS21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RGS21:
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptorcomplexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998)class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby acceleratesignaling kinetics and termination.(supplied by OMIM, Nov 2008)
UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby drivingthem into their inactive GDP-bound form (By similarity)
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Genomic Views
for RGS21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RGS21 gene promoter:
POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) CUTL1 POU3F2 Tal-1beta E47 S8 SREBP-1a FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RGS21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q31.1 Ensembl cytogenetic band: 1q31.2 HGNC cytogenetic band: 1q31.1RGS21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P192286: view genomic region
(about GC identifiers)
Start:
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192,286,122 bp from pter |
End:
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192,336,415 bp from pter |
Size:
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50,294 bases |
Orientation:
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plus strand |
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Proteins
for RGS21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4 (See
protein sequence)Recommended Name: Regulator of G-protein signaling 21 Size: 152 amino acids; 17671 DaExplore the universe of human proteins at neXtProt for RGS21: NX_Q2M5E4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2M5E4
RGS21 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001034241.1
ENSEMBL proteins: ENSP00000428343
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RGS21 for ontologies About GeneDecksing
RGS21 Antibody Products:
Assay Products for RGS21: |
Protein
Domains /
Families
for RGS21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RGS21 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2M5E4ProtoNet protein and cluster: Q2M5E4 1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature
UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4Similarity: Contains 1 RGS domain |
Function
for RGS21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby drivingthem into their inactive GDP-bound form (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IBA | -- |
RGS21 for ontologies About GeneDecksing
|
Pathways & Interactions
for RGS21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | G-AlphaQ Signaling | | | 2 | Activation of cAMP-Dependent PKA | |
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS21
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGS21
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0038032 | termination of G-protein coupled receptor signaling pathway |
IEA | -- | | GO:0043547 | positive regulation of GTPase activity |
IBA | -- |
RGS21 for ontologies About GeneDecksing
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Drugs & Compounds
for RGS21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RGS21
Search CenterWatch for drugs/clinical trials and news about RGS21
|
Transcripts
for RGS21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RGS21 gene: NM_001039152.3 Unigene Cluster for RGS21: Regulator of G-protein signaling 21 Hs.558673 [show with all ESTs]Unigene Representative Sequence: AY6437111 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000417209(uc001gsh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS21
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RGS21 (NM_001039152) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGS21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS21 |
Additional cDNA sequence: AY643711.1 1 DOTS entry: DT.121454037
GeneLoc Exon Structure
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Expression
for RGS21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RGS21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.558673
UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4Tissue specificity: Expressed ubiquitously
SABiosciences Custom PCR Arrays for RGS21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RGS21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS21 |
Orthologs
for RGS21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RGS21 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for RGS21 (if available)
TreeFam Gene Tree for RGS21 (if available) |
Paralogs
for RGS21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RGS21 gene
- RGS22 RGS82 RGS192 RGS32 RGS162 RGS202 RGS52 RGS172
- RGS12 RGS182 RGS42 RGS132
18 SIMAP similar genes for RGS21 using alignment to 1 protein entry: RGS21_HUMAN:RGS18 RGS8 RGS1 RGS5 RGS4 RGS17
RGS2 RGS20 RGS3 RGS13 RGS16 RGS19
RGS6 RGS10 RGS7 RGS9 AXIN2 RGS12
RGS21 for paralogs About GeneDecksing
|
Genomic Variants
for RGS21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RGS21 (192286122 - 192336415 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RGS21: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for RGS21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RGS21 for disorders About MalaCards
RGS21 for disorders About GeneDecksing
OMIM gene information: 612407
OMIM disorders: --
Export disorders for RGS21 gene to outside databases
|
Publications
for RGS21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RGS21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RGS21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and expression pattern of RGS21 gene, a novel RGS member. (PubMed id 16302027)1, 2 Li X.... Mao Y. (2005)
- RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. (PubMed id 15066150)1, 3 von Buchholtz L....Conzelmann S. (2004)
- Regulator of G-protein signaling-21 (RGS21) is an inhi bitor of bitter gustatory signaling found in lingual and airway epithelia. (PubMed id 23095746)1 Cohen S.P....Kimple A.J. (2012)
- Genome-wide linkage and association scans for pulse pressure in Chinese twins. (PubMed id 22763476)1 Zhang D....Tan Q. (2012)
|
External Searches for RGS21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RGS21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RGS21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RGS21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RGS21 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RGS21 gene:
Search GeneIP for patents involving RGS21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RGS21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RGS21 | | OriGene shRNA RFP for RGS21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RGS21 | | | OriGene Protein Over-expression Lysate for RGS21 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RGS21 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGS21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGS21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RGS21 | | OriGene Custom Protein Services for RGS21 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGS21 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGS21 |
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| |  |  |  |  | | | | | | Recombinant Protein for RGS21 |
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