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RGS21 Gene

protein-coding   GIFtS: 39
GCID: GC01P192286

Regulator Of G-Protein Signaling 21

(Previous name: regulator of G-protein signalling 21)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 211 2
Regulator Of G-Protein Signalling 211 2

External Ids:    HGNC: 268391   Entrez Gene: 4317042   Ensembl: ENSG000002531487   OMIM: 6124075   UniProtKB: Q2M5E43   

Export aliases for RGS21 gene to outside databases

Previous GC identifers: GC00U914493 GC01U901126 GC01P190552 GC01P163522


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS21 Gene:
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled
receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ;
MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and
thereby accelerate signaling kinetics and termination.(supplied by OMIM, Nov 2008)

GeneCards Summary for RGS21 Gene:
RGS21 (regulator of G-protein signaling 21) is a protein-coding gene. Diseases associated with RGS21 include celiac disease. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS21 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   POU3F2   Tal-1beta   E47   S8   SREBP-1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RGS21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.2   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31.2

RGS21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P192286:  view genomic region     (about GC identifiers)

Start:
192,286,122 bp from pter      End:
192,336,415 bp from pter
Size:
50,294 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 21  
Size: 152 amino acids; 17671 Da

Explore the universe of human proteins at neXtProt for RGS21: NX_Q2M5E4

Explore proteomics data for RGS21 at MOPED


See RGS21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001034241.1  
ENSEMBL proteins: 
 ENSP00000428343  
Reactome Protein details: Q2M5E4

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RGS: Regulators of G-protein signaling

3 InterPro protein domains:
 IPR024066 Regulat_G_prot_signal_dom1
 IPR016137 Regulat_G_prot_signal_superfam
 IPR000342 RGS_dom

Graphical View of Domain Structure for InterPro Entry Q2M5E4

ProtoNet protein and cluster: Q2M5E4

1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4
Similarity: Contains 1 RGS domain


RGS21 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RGS21_HUMAN, Q2M5E4
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005096GTPase activator activity IBA--
     
RGS21 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IBA--
GO:0005886plasma membrane IBA--

RGS21 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RGS21 About    
See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
2Gastrin-CREB signalling pathway via PKC and MAPK
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
3G-AlphaQ Signaling
G-AlphaQ Signaling0.47
G-AlphaI Signaling0.47
4Activation of cAMP-Dependent PKA
cAMP Pathway0.77
5Peptide ligand-binding receptors
G alpha (i) signalling events0.44

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS21
    cAMP Pathway
G-AlphaI Signaling
G-AlphaQ Signaling

2 Reactome Pathways for RGS21
    G alpha (q) signalling events
G alpha (i) signalling events



RGS21 for pathways           About GeneDecksing

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Interactions:

    Search GeneGlobe Interaction Network for RGS21

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
GO:0043547positive regulation of GTPase activity IBA--

RGS21 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for RGS21



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RGS21 gene: 
NM_001039152.3  

Unigene Cluster for RGS21:

Regulator of G-protein signaling 21
Hs.558673  [show with all ESTs]
Unigene Representative Sequence: AY643711
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000417209(uc001gsh.3)
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Additional mRNA sequence: AY643711.1 

1 DOTS entry:

DT.121454037 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RGS21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RGS21 Expression
About this image

RGS21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RGS21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.558673

UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4
Tissue specificity: Expressed ubiquitously

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RGS21 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rgs211 , 5 regulator of G-protein signalling 211, 5 88.82(n)1
87.5(a)1
  1 (62.66 cM)5
6249101  XM_889451.31  XP_894544.31 
 1445166735 
chicken
(Gallus gallus)
Aves RGS211 regulator of G-protein signaling 21 72.37(n)
71.05(a)
  101751608  XM_004943137.1  XP_004943194.1 
lizard
(Anolis carolinensis)
Reptilia RGS216
regulator of G-protein signaling 21
73(a)
1 ↔ 1
GL343267.1(1653528-1662937)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rgs211 regulator of G-protein signaling 21 67.26(n)
69.64(a)
  100485901  XM_002939077.2  XP_002939123.2 
zebrafish
(Danio rerio)
Actinopterygii rgs11 regulator of G-protein signaling 1 55.97(n)
49.25(a)
  556179  XM_678917.5  XP_684009.4 


ENSEMBL Gene Tree for RGS21 (if available)
TreeFam Gene Tree for RGS21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RGS21 gene
RGS22  RGS82  RGS192  RGS32  RGS202  RGS162  RGS172  RGS52  
RGS12  RGS182  RGS132  RGS42  
16 SIMAP similar genes for RGS21 using alignment to 1 protein entry:     RGS21_HUMAN:
RGS18    RGS8    RGS1    RGS5    RGS4    RGS17
RGS2    RGS20    RGS3    RGS13    RGS16    RGS19
RGS6    RGS10    RGS7    RGS9

RGS21 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RGS21 (see all 1036)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1399840171,2
C--192284186(+) TTACCA/GTAAAT 1 -- us2k10--------
rs66591101,2
C,F,A,H--192284218(+) AAAATT/CTGTTT 1 -- us2k116Minor allele frequency- C:0.44NS EA NA WA CSA 866
rs1493320061,2
--192284231(+) TTGGAA/TGAGAC 1 -- us2k10--------
rs1900349131,2
--192284291(+) ACCTCC/TAATCA 1 -- us2k10--------
rs13391301,2
C,F,A,H--192284317(+) ATTACG/ATTCAA 1 -- us2k110Minor allele frequency- A:0.29EA NS WA NA CSA 647
rs120585911,2
C,F,H--192284325(+) CAATAT/CGCATT 1 -- us2k16Minor allele frequency- C:0.11EA NS NA WA 538
rs1816241641,2
--192284521(+) AAATAG/TGTCAT 1 -- us2k10--------
rs751369241,2
C,F--192284576(+) CTAAGT/CGGCAT 1 -- us2k11Minor allele frequency- C:0.04NA 120
rs1858474941,2
C--192284606(+) GTAAGC/TCTGTA 1 -- us2k10--------
rs1924807581,2
--192284647(+) AAGTAC/TTTGTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RGS21 (192286122 - 192336415 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for RGS21:    About this table    
Variant IDTypeSubtypePubMed ID
esv271432CNV Insertion20981092
dgv468n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for RGS21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612407    OMIM disorders: --

1 disease for RGS21:    
About MalaCards
celiac disease


RGS21 for disorders           About GeneDecksing

Genetic Association Database (GAD): RGS21

Export disorders for RGS21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RGS21 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RGS21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation and expression pattern of RGS21 gene, a novel RGS member. (PubMed id 16302027)1, 2 Li X.... Mao Y. (Acta Biochim. Pol. 2005)
  2. RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. (PubMed id 15066150)1, 3 von Buchholtz L....Conzelmann S. (Eur. J. Neurosci. 2004)
  3. Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. (PubMed id 23095746)1 Cohen S.P....Kimple A.J. (J. Biol. Chem. 2012)
  4. Genome-wide linkage and association scans for pulse pressure in Chinese twins. (PubMed id 22763476)1 Zhang D....Tan Q. (Hypertens. Res. 2012)
  5. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
  6. Newly identified genetic risk variants for celiac disease related to the immune response. (PubMed id 18311140)4 Hunt K.A.... van Heel D.A. (Nat. Genet. 2008)
  7. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 431704 HGNC: 26839 Ensembl:ENSG00000253148 euGenes: HUgn431704 ECgene: RGS21
H-InvDB: RGS21

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RGS21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RGS21 gene:
Search GeneIP for patents involving RGS21

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS21
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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