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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS21 Gene

protein-coding   GIFtS: 39
GCID: GC01P192286

Regulator Of G-Protein Signaling 21

(Previous name: regulator of G-protein signalling 21)
  Search for RGS21
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 211 2
Regulator Of G-Protein Signalling 211 2

External Ids:    HGNC: 268391   Entrez Gene: 4317042   Ensembl: ENSG000002531487   OMIM: 6124075   UniProtKB: Q2M5E43   

Export aliases for RGS21 gene to outside databases

Previous GC identifers: GC00U914493 GC01U901126 GC01P190552 GC01P163522


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS21 Gene:
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled
receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ;
MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and
thereby accelerate signaling kinetics and termination.(supplied by OMIM, Nov 2008)

GeneCards Summary for RGS21 Gene: 
RGS21 (regulator of G-protein signaling 21) is a protein-coding gene. Among its related super-pathways are G-AlphaQ Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS21 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   POU3F2   Tal-1beta   E47   S8   SREBP-1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RGS21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.2   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31.2

RGS21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P192286:  view genomic region     (about GC identifiers)

Start:
192,286,122 bp from pter      End:
192,336,415 bp from pter
Size:
50,294 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 21  
Size: 152 amino acids; 17671 Da

Explore the universe of human proteins at neXtProt for RGS21: NX_Q2M5E4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2M5E4

  • RGS21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001034241.1  
    ENSEMBL proteins: 
     ENSP00000428343  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--

    RGS21 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry Q2M5E4

    ProtoNet protein and cluster: Q2M5E4

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4
    Similarity: Contains 1 RGS domain


    RGS21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS21_HUMAN, Q2M5E4
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
         
    RGS21 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGS21 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Activation of cAMP-Dependent PKA
    cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS21
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGS21

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity IBA--

    RGS21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS21

    Search CenterWatch for drugs/clinical trials and news about RGS21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for RGS21 gene: 
    NM_001039152.3  

    Unigene Cluster for RGS21:

    Regulator of G-protein signaling 21
    Hs.558673  [show with all ESTs]
    Unigene Representative Sequence: AY643711
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000417209(uc001gsh.3)
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    Additional mRNA sequence: AY643711.1 

    1 DOTS entry:

    DT.121454037 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RGS21 Expression
    About this image


    SOURCE GeneReport for Unigene cluster: Hs.558673

    UniProtKB/Swiss-Prot: RGS21_HUMAN, Q2M5E4
    Tissue specificity: Expressed ubiquitously

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RGS21 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs211 , 5 regulator of G-protein signalling 211, 5 88.82(n)1
    87.5(a)1
      1 (62.66 cM)5
    6249101  XM_889451.31  XP_894544.31 
     1445196905 
    chicken
    (Gallus gallus)
    Aves RGS216
    regulator of G-protein signaling 21
    60(a)
    1 ↔ 1
    8(3629679-3632272)
    lizard
    (Anolis carolinensis)
    Reptilia RGS216
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343267.1(1653528-1662937)
    zebrafish
    (Danio rerio)
    Actinopterygii rgs16
    regulator of G-protein signaling 1
    40(a)
    1 → many
    2(6216200-6223208)


    ENSEMBL Gene Tree for RGS21 (if available)
    TreeFam Gene Tree for RGS21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS21 gene
    RGS22  RGS82  RGS192  RGS32  RGS202  RGS162  RGS172  RGS52  
    RGS12  RGS182  RGS132  RGS42  
    16 SIMAP similar genes for RGS21 using alignment to 1 protein entry:     RGS21_HUMAN:
    RGS18    RGS8    RGS1    RGS5    RGS4    RGS17
    RGS2    RGS20    RGS3    RGS13    RGS16    RGS19
    RGS6    RGS10    RGS7    RGS9

    RGS21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1036 SNPs in RGS21 are shown (see all 1036)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399840171,2
    C--192284186(+) TTACCA/GTAAAT 1 -- us2k10--------
    rs66591101,2
    C,F,A,H--192284218(+) AAAATT/CTGTTT 1 -- us2k116Minor allele frequency- C:0.44NS EA NA WA CSA 866
    rs1493320061,2
    --192284231(+) TTGGAA/TGAGAC 1 -- us2k10--------
    rs1900349131,2
    --192284291(+) ACCTCC/TAATCA 1 -- us2k10--------
    rs13391301,2
    C,F,A,H--192284317(+) ATTACG/ATTCAA 1 -- us2k110Minor allele frequency- A:0.29EA NS WA NA CSA 647
    rs120585911,2
    C,F,H--192284325(+) CAATAT/CGCATT 1 -- us2k16Minor allele frequency- C:0.11EA NS NA WA 538
    rs1816241641,2
    --192284521(+) AAATAG/TGTCAT 1 -- us2k10--------
    rs751369241,2
    C,F--192284576(+) CTAAGT/CGGCAT 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1858474941,2
    C--192284606(+) GTAAGC/TCTGTA 1 -- us2k10--------
    rs1924807581,2
    --192284647(+) AAGTAC/TTTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGS21 (192286122 - 192336415 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RGS21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv271432CNV Insertion20981092
    dgv468n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RGS21 for disorders           About MalaCards
    OMIM gene information: 612407    OMIM disorders: --


    RGS21 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS21

    Export disorders for RGS21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS21 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RGS21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and expression pattern of RGS21 gene, a novel RGS member. (PubMed id 16302027)1, 2 Li X.... Mao Y. (2005)
    2. RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. (PubMed id 15066150)1, 3 von Buchholtz L....Conzelmann S. (2004)
    3. Regulator of G-protein signaling-21 (RGS21) is an inhi bitor of bitter gustatory signaling found in lingual and airway epithelia. (PubMed id 23095746)1 Cohen S.P....Kimple A.J. (2012)
    4. Genome-wide linkage and association scans for pulse pressure in Chinese twins. (PubMed id 22763476)1 Zhang D....Tan Q. (2012)
    5. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)4 Dubois P.C....van Heel D.A. (2010)
    6. Newly identified genetic risk variants for celiac disease related to the immune response. (PubMed id 18311140)4 Hunt K.A.... van Heel D.A. (2008)
    7. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 431704 HGNC: 26839 Ensembl:ENSG00000253148 euGenes: HUgn431704 ECgene: RGS21
    H-InvDB: RGS21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGS21 gene:
    Search GeneIP for patents involving RGS21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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