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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS20 Gene

protein-coding   GIFtS: 57
GCID: GC08P054764

regulator of G-protein signaling 20

(Previous name: regulator of G-protein signalling 20 )
 Explore 5 diseases affiliated with
RGS20 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGS20    

Aliases
for RGS20 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of G-Protein Signaling 201 2     Regulator Of Gz-Selective Protein Signaling 12 3
RGSZ11 2 3     G(Z)GAP1
ZGAP11 2 3     Gz-GAP3
Regulator Of G-Protein Signalling 201 2     Regulator Of G-Protein Signaling 20 Variant 22
Gz-Selective GTPase-Activating Protein2 3     G(Z)GAP1
Regulator Of G-Protein Signaling Z12 3     Gz-GAP3

External Ids:    HGNC: 146001   Entrez Gene: 86012   Ensembl: ENSG000001475097   OMIM: 6071935   UniProtKB: O760813   

Export aliases for RGS20 gene to outside databases

Previous GC identifers: GC08P054063 GC08P054703 GC08P054488 GC08P054814 GC08P054926 GC08P050231


Summaries
for RGS20 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RGS20:
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are
regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction
by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound
forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling
activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their
GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation
and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By
similarity)

Gene Wiki entry for RGS20


Genomic Views
for RGS20 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS20 gene promoter:
         Pax-2   Pax-2a   POU2F1   POU2F1b   POU2F1a   FOXJ2 (long isoform)   HFH-1   ZIC2/Zic2   FOXJ2   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGS20 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.23   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8q11.23

RGS20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS20 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P054764:  view genomic region     (about GC identifiers)

Start:
 54,764,368 bp from pter      End:
 54,871,863 bp from pter
Size:
 107,496 bases      Orientation:
 plus strand

Proteins
for RGS20 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 20  
Size: 388 amino acids; 43692 Da
Subunit: Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in
mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity)
Subcellular location: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and
the nucleus (By similarity). Anchored to the membrane through palmitoylation (By similarity)
Secondary accessions: Q96BG9
Alternative splicing: 6 isoforms:  O76081-1   O76081-2   O76081-3   O76081-4   O76081-5   O76081-6   

Explore the universe of human proteins at neXtProt for RGS20: NX_O76081

Post-translational modifications:

  • Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity)1
  • N- and O-glycosylated in synapsomal membranes (By similarity)1
  • Serine phosphorylated in synapsomal membranes (By similarity)1
  • Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid
    • receptor-activated G(alpha) subunits (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O76081

    • RGS20 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003693.2  NP_733466.1  

    ENSEMBL proteins: 
     ENSP00000297313   ENSP00000428795   ENSP00000344630   ENSP00000429897   ENSP00000430627  
     ENSP00000276500  

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    Novus Biologicals RGS20 Proteins
    Novus Biologicals RGS20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RGS20

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--


    RGS20 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RGS20

    Protein Domains /
    Families
    for RGS20 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RGS20 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry O76081

    ProtoNet protein and cluster: O76081

    1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081
    Similarity: Contains 1 RGS domain


    Function
    for RGS20 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
    them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their
    GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation
    and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By
    similarity)

    miRNA
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    hsa-miR-3065-5p hsa-miR-496 hsa-miR-4293 hsa-miR-218 hsa-miR-636 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmid: RGS20 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: RGS20
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI--


    RGS20 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RGS20:
     Decreased number of cells in m 

    Animal Models:
         1 MGI phenotypic allele for Rgs20 (no phenotypes)

    RGS20 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RGS20 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-AlphaQ Signaling
    		G-AlphaQ Signaling1.00
    		G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    		Calcium Regulation in the Cardiac Cell1.00
    		Myometrial Relaxation and Contraction Pathways0.43
    3Activation of cAMP-Dependent PKA
    		cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS20
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    2 BioSystems Pathways for RGS20 
        Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/154 Interacting proteins for RGS20 (O760811, 2, 3 ENSP000002973134) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTNR1BP492862, 3, ENSP000002570684MINT-8087055 MINT-8087089 I2D: score=1 STRING: ENSP00000257068
    ABL1P005192, 3, ENSP000003614234MINT-8110683 I2D: score=3 STRING: ENSP00000361423
    MTNR1AP480392, 3, ENSP000003028114MINT-8087198 MINT-8087089 MINT-8087146 MINT-8087131 MINT-8087181 MINT-8087038 MINT-8087164 I2D: score=1 STRING: ENSP00000302811
    BOLA1Q9Y3E23, ENSP000003581464I2D: score=2 STRING: ENSP00000358146
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS9748279
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS9748279


    RGS20 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGS20 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS20
    2 Novoseek chemical compound relationships for RGS20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 48.5 1 9748280 (1)
    phospholipid 42.4 2 9748280 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS20 

    Transcripts
    for RGS20 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGS20 gene (2 alternative transcripts): 
    NM_003702.3  NM_170587.2  

    Unigene Cluster for RGS20:

    Regulator of G-protein signaling 20
    Hs.741492  [show with all ESTs]
    Unigene Representative Sequence: NM_170587
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297313(uc003xrp.3 uc003xrq.3 uc010lye.3 uc010lyf.3)
    ENST00000517659 ENST00000344277 ENST00000523280 ENST00000518286 ENST00000523414
    ENST00000522225(uc003xrt.3) ENST00000276500(uc003xrs.3) ENST00000523064(uc003xrr.2)
    ENST00000517405

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS20:
    hsa-miR-3065-5p hsa-miR-496 hsa-miR-4293 hsa-miR-218 hsa-miR-636 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmid: RGS20 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RGS20 (see all 7)
    OriGene shRNA RFP: RGS20
    OriGene siRNA: RGS20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGS20
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RGS20 (NM_170587)
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    Additional cDNA sequence: 

    AF060877.2 AF074979.1 AF366054.1 AF366055.1 AF366056.1 AF366057.1 AF493940.1 AK094503.1 
    AY046538.1 BC015614.2 BC018618.1 BC031328.1 BC054867.1 BC063490.1 JQ308180.1 

    10 DOTS entries:

    DT.409664  DT.95263258  DT.121474930  DT.95263260  DT.92028682  DT.99952419  DT.121474891  DT.121474902 
    DT.121474947  DT.97809650 

    24/63 AceView cDNA sequences (see all 63):

    N47280 BX281538 BC015614 CB141523 BG760472 AA450144 BC063490 BQ020924 
    BU615460 CR602987 AL525981 AF074979 AI435005 AF493940 AA626204 BF589264 
    AA242973 CR594448 BC018618 AI264190 CR622266 BC031328 AK094503 AA450087 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RGS20 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:              -     -     -           -                                       
    SP2:        -     -     -     -           -                                       
    SP3:                          -           -                                       
    SP4:        -     -     -     -     -     -                                       
    SP5:                    -     -           -                                       


    ECgene alternative splicing isoforms for RGS20

    Expression
    for RGS20 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCACAACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RGS20 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungRespiratory BronchiolesBasal CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See RGS20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS20

    SOURCE GeneReport for Unigene cluster: Hs.741492

    UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081
    Tissue specificity: Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe

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    In Situ
    Assay Products:     
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    Orthologs
    for RGS20 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RGS20 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RGS201 regulator of G-protein signaling 20 80.49(n)
    84.79(a)    		   395646  NM_204842.2  NP_990173.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RGS206
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343244.1(1186309-1196703)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.110712 Transcribed sequence with weak similarity to protein more 76.42(n)    BG307106.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta EG:52C10.23
    CG50361    		 regulation of G-protein coupled receptor
    protein more3
    CG50361    		 61(a)3
    65.66(n)1
    66.87(a)1    		   54E93
    370371  NM_137427.31  NP_611271.31 
    worm
    (Caenorhabditis elegans)    		 Secernentea rgs-11 Protein RGS-1 59.29(n)
    61.83(a)    		   176415  NM_066820.3  NP_499221.1 


    ENSEMBL Gene Tree for RGS20 (if available)
    TreeFam Gene Tree for RGS20 (if available) 

    Paralogs
    for RGS20 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS20 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS162  RGS52  RGS172  
    RGS12  RGS182  RGS42  RGS132  
    18 SIMAP similar genes for RGS20 using alignment to 5 protein entries:     RGS20_HUMAN (see all proteins):
    RGS17    RGS19    RGS21    RGS1    RGS9    RGS4
    RGS8    RGS10    RGS18    RGS2    RGS5    RGS6
    RGS3    RGS13    RGS11    RGS7    RGS16    AXIN2

    RGS20 for paralogs           About GeneDecksing



    Genomic Variants
    for RGS20 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1818 NCBI SNPs in RGS20 are shown (see all 1818)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs69943321,2
    		C,A,--54762380(+) ATTTTG/CTTCTA 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1840265951,2
    		--54762395(+) TTTTAC/TAGTTT 1 -- us2k10--------
    rs1879661281,2
    		--54762411(+) TTTATA/GTTTAA 1 -- us2k10--------
    rs1927091181,2
    		--54762469(+) GGTCCA/GGTTTC 1 -- us2k10--------
    rs125487671,2
    		H--54762509(+) ccaacA/Cccatt 1 -- us2k10--------
    rs122348881,2
    		H--54762574(+) tttcaG/Aatttg 1 -- us2k14Minor allele frequency- A:0.00NS EA 400
    rs1845110141,2
    		--54762848(+) CTGTAA/GCTTTG 1 -- us2k10--------
    rs1455639721,2
    		--54762869(+) TAAAAC/TTGGGA 1 -- us2k10--------
    rs64738951,2
    		C,F,H,--54762904(+) TTATCG/AAGACT 1 -- us2k129Minor allele frequency- A:0.04NS EA NA WA CSA 2544
    rs1488876301,2
    		--54762916(+) TTTTGA/GATATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGS20 (54764368 - 54871863 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RGS20
         1 CNV: 3735

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    Disorders / Diseases
    for RGS20 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGS20 for disorders           About GeneDecksing

    OMIM gene information: 607193    OMIM disorders: --

    5 diseases for RGS20:    About MalaCards
    squamous cell carcinoma    hypertension    pharyngitis    carcinoma
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: RGS20 (2 documents)

    Export disorders for RGS20 gene to outside databases

    Publications
    for RGS20 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS20 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RGS20)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily. (PubMed id 9748280)1, 2, 3, 9 Wang J.... Ross E.M. (1998)
    2. RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. (PubMed id 9748279)1, 2, 3 Glick J.L.... Casey P.J. (1998)
    3. RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. (PubMed id 11735229)1, 2, 9 Barker S.A.... Ross E.M. (2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling. (PubMed id 12379657)1, 2 Wang Y....Young K.H. (2002)
    6. Genetic variations in regulator of G-protein signalin g genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1 Wang J....Wu X. (2010)
    7. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PubMed id 18360038)1 Kohara K....Miki T. (2008)
    8. Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways. (PubMed id 18407463)1 Pagano M....Iyengar R. (2008)
    9. RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. (PubMed id 17126529)1 Ajit S.K....Young K.H. (2007)
    10. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)

    External Searches for RGS20 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing RGS20 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8601 HGNC: 14600 AceView: RGS20 Ensembl:ENSG00000147509 euGenes: HUgn8601
    ECgene: RGS20 H-InvDB: RGS20

    Other Databases showing RGS20 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RGS20 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS20 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RGS20 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RGS20 gene:
    Search GeneIP for patents involving RGS20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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