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Aliases for RGS20 Gene

Aliases for RGS20 Gene

  • Regulator Of G-Protein Signaling 20 2 3
  • Regulator Of Gz-Selective Protein Signaling 1 3 4
  • Gz-Selective GTPase-Activating Protein 3 4
  • Regulator Of G-Protein Signalling 20 2 3
  • Regulator Of G-Protein Signaling Z1 3 4
  • G(Z)GAP 3 4
  • Gz-GAP 3 4
  • RGSZ1 3 4
  • ZGAP1 3 4
  • Regulator Of G-Protein Signaling 20 Variant 2 3

External Ids for RGS20 Gene

Previous GeneCards Identifiers for RGS20 Gene

  • GC08P054063
  • GC08P054703
  • GC08P054488
  • GC08P054814
  • GC08P054926
  • GC08P054764
  • GC08P050231

Summaries for RGS20 Gene

Entrez Gene Summary for RGS20 Gene

  • The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for RGS20 Gene

RGS20 (Regulator Of G-Protein Signaling 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS20 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Gene Wiki entry for RGS20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS20 Gene

Genomics for RGS20 Gene

Regulatory Elements for RGS20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGS20 Gene

Chromosome:
8
Start:
53,851,808 bp from pter
End:
53,959,304 bp from pter
Size:
107,497 bases
Orientation:
Plus strand

Genomic View for RGS20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS20 Gene

Proteins for RGS20 Gene

  • Protein details for RGS20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76081-RGS20_HUMAN
    Recommended name:
    Regulator of G-protein signaling 20
    Protein Accession:
    O76081
    Secondary Accessions:
    • Q96BG9

    Protein attributes for RGS20 Gene

    Size:
    388 amino acids
    Molecular mass:
    43692 Da
    Quaternary structure:
    • Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity).

    Alternative splice isoforms for RGS20 Gene

neXtProt entry for RGS20 Gene

Proteomics data for RGS20 Gene at MOPED

Post-translational modifications for RGS20 Gene

  • Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).
  • N- and O-glycosylated in synapsomal membranes.
  • Serine phosphorylated in synapsomal membranes.
  • Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS20 Gene

Domains & Families for RGS20 Gene

Gene Families for RGS20 Gene

Protein Domains for RGS20 Gene

Graphical View of Domain Structure for InterPro Entry

O76081

UniProtKB/Swiss-Prot:

RGS20_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS20: view

Function for RGS20 Gene

Molecular function for RGS20 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Gene Ontology (GO) - Molecular Function for RGS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 9748279
GO:0005515 protein binding IPI 20859254
genes like me logo Genes that share ontologies with RGS20: view
genes like me logo Genes that share phenotypes with RGS20: view

Animal Model Products

miRNA for RGS20 Gene

miRTarBase miRNAs that target RGS20

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS20 Gene

Localization for RGS20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS20 Gene

Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS20 Gene COMPARTMENTS Subcellular localization image for RGS20 gene
Compartment Confidence
nucleus 5
golgi apparatus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RGS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IMP 10791963
GO:0005802 trans-Golgi network IMP 10791963
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS20: view

Pathways & Interactions for RGS20 Gene

genes like me logo Genes that share pathways with RGS20: view

Gene Ontology (GO) - Biological Process for RGS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9748279
GO:0009968 negative regulation of signal transduction IEA --
GO:0038032 termination of G-protein coupled receptor signaling pathway --
GO:0043547 positive regulation of GTPase activity TAS 9748279
genes like me logo Genes that share ontologies with RGS20: view

No data available for SIGNOR curated interactions for RGS20 Gene

Drugs & Compounds for RGS20 Gene

(1) Drugs for RGS20 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cysteine Nutra 143

(1) Additional Compounds for RGS20 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phospholipid
genes like me logo Genes that share compounds with RGS20: view

Transcripts for RGS20 Gene

Unigene Clusters for RGS20 Gene

Regulator of G-protein signaling 20:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - - - - - - -
SP9:

Relevant External Links for RGS20 Gene

GeneLoc Exon Structure for
RGS20
ECgene alternative splicing isoforms for
RGS20

Expression for RGS20 Gene

mRNA expression in normal human tissues for RGS20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS20 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x9.1), Brain - Caudate (basal ganglia) (x8.6), Brain - Putamen (basal ganglia) (x7.6), and Brain - Amygdala (x5.5).

Protein differential expression in normal tissues from HIPED for RGS20 Gene

This gene is overexpressed in Lung (55.5) and Liver (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGS20 Gene



SOURCE GeneReport for Unigene cluster for RGS20 Gene Hs.368733

mRNA Expression by UniProt/SwissProt for RGS20 Gene

O76081-RGS20_HUMAN
Tissue specificity: Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe
genes like me logo Genes that share expression patterns with RGS20: view

Protein tissue co-expression partners for RGS20 Gene

Primer Products

In Situ Assay Products

Orthologs for RGS20 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS20 35
  • 78.8 (n)
  • 82.95 (a)
RGS20 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS20 35
  • 84.13 (n)
  • 83.6 (a)
RGS20 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs20 35
  • 73.17 (n)
  • 65.85 (a)
Rgs20 16
Rgs20 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS20 35
  • 99.4 (n)
  • 99.74 (a)
RGS20 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs20 35
  • 78.61 (n)
  • 78.33 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS20 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS20 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS20 35
  • 80.49 (n)
  • 84.79 (a)
RGS20 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS20 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs20 35
  • 76.42 (n)
  • 81.13 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11071 35
rgs20 35
  • 71.12 (n)
  • 73.73 (a)
rgs20 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:52C10.2 37
  • 61 (a)
CG5036 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-2 35
  • 61.19 (n)
  • 63.43 (a)
rgs-1 36
  • 36 (a)
ManyToMany
rgs-2 36
  • 51 (a)
ManyToMany
Species with no ortholog for RGS20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS20 Gene

ENSEMBL:
Gene Tree for RGS20 (if available)
TreeFam:
Gene Tree for RGS20 (if available)

Paralogs for RGS20 Gene

Paralogs for RGS20 Gene

(18) SIMAP similar genes for RGS20 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RGS20: view

Variants for RGS20 Gene

Sequence variations from dbSNP and Humsavar for RGS20 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs729016 -- 53,941,145(+) GCGGG(G/T)CAGGT intron-variant
rs936685 -- 53,898,373(-) AAAGA(A/T)AAAGG intron-variant
rs1004228 -- 53,882,681(+) CGCTC(C/T)TTGTC intron-variant
rs1123133 -- 53,867,554(+) GCACT(C/G)TTTAC intron-variant
rs1132246 -- 53,959,106(+) CAGCA(A/G)TGCTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS20 Gene

Variant ID Type Subtype PubMed ID
essv22151 CNV CNV 17122850
esv2737005 CNV Deletion 23290073

Variation tolerance for RGS20 Gene

Residual Variation Intolerance Score: 61.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS20 Gene

HapMap Linkage Disequilibrium report
RGS20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS20 Gene

Disorders for RGS20 Gene

Relevant External Links for RGS20

Genetic Association Database (GAD)
RGS20
Human Genome Epidemiology (HuGE) Navigator
RGS20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS20
genes like me logo Genes that share disorders with RGS20: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS20 Gene

Publications for RGS20 Gene

  1. RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily. (PMID: 9748280) Wang J. … Ross E.M. (J. Biol. Chem. 1998) 2 23 67
  2. GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. (PMID: 12640130) Xia C. … Liu M. (Mol. Cell. Biol. 2003) 23 67
  3. Binding of regulator of G protein signaling (RGS) proteins to phospholipid bilayers. Contribution of location and/or orientation to Gtpase-activating protein activity. (PMID: 11274219) Tu Y. … Ross E.M. (J. Biol. Chem. 2001) 23 67
  4. RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. (PMID: 11735229) Barker S.A. … Ross E.M. (Genomics 2001) 23 67
  5. RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. (PMID: 9748279) Glick J.L. … Casey P.J. (J. Biol. Chem. 1998) 2 67

Products for RGS20 Gene

Sources for RGS20 Gene

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