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RGS20 Gene

protein-coding   GIFtS: 60
GCID: GC08P054764

Regulator Of G-Protein Signaling 20

(Previous name: regulator of G-protein signalling 20)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 201 2     ZGAP12 3
Regulator Of G-Protein Signalling 201 2     g(z)GAP2
Gz-Selective GTPase-Activating Protein2 3     gz-GAP2
Regulator Of G-Protein Signaling Z12 3     Regulator Of G-Protein Signaling 20 Variant 22
Regulator Of Gz-Selective Protein Signaling 12 3     G(z)GAP3
RGSZ12 3     Gz-GAP3

External Ids:    HGNC: 146001   Entrez Gene: 86012   Ensembl: ENSG000001475097   OMIM: 6071935   UniProtKB: O760813   

Export aliases for RGS20 gene to outside databases

Previous GC identifers: GC08P054063 GC08P054703 GC08P054488 GC08P054814 GC08P054926 GC08P050231


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS20 Gene:
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which
are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal
transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their
inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates
their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for RGS20 Gene:
RGS20 (regulator of G-protein signaling 20) is a protein-coding gene. Diseases associated with RGS20 include bronchiolitis, and hypertension. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits,
accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited
by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated
activation of the G-proteins (By similarity)

Gene Wiki entry for RGS20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS20 gene promoter:
         Pax-2   Pax-2a   POU2F1   POU2F1b   POU2F1a   FOXJ2 (long isoform)   HFH-1   ZIC2/Zic2   FOXJ2   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGS20 promoter sequence
   Search Chromatin IP Primers for RGS20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.23   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8q11.23

RGS20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS20 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P054764:  view genomic region     (about GC identifiers)

Start:
54,764,368 bp from pter      End:
54,871,863 bp from pter
Size:
107,496 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 20  
Size: 388 amino acids; 43692 Da
Subunit: Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results
in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity)
Secondary accessions: Q96BG9
Alternative splicing: 6 isoforms:  O76081-1   O76081-2   O76081-3   O76081-4   O76081-5   O76081-6   

Explore the universe of human proteins at neXtProt for RGS20: NX_O76081

Explore proteomics data for RGS20 at MOPED

Post-translational modifications: 

  • Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity)1
  • N- and O-glycosylated in synapsomal membranes (By similarity)1
  • Serine phosphorylated in synapsomal membranes (By similarity)1
  • Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid
    receptor-activated G(alpha) subunits (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001273602.1  NP_001273603.1  NP_001273604.1  NP_003693.2  NP_733466.1  

    ENSEMBL proteins: 
     ENSP00000297313   ENSP00000428795   ENSP00000344630   ENSP00000429897   ENSP00000430627  
     ENSP00000276500  
    Reactome Protein details: O76081

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    Cloud-Clone Corp. Proteins for RGS20

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    Cloud-Clone Corp. CLIAs for RGS20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry O76081

    ProtoNet protein and cluster: O76081

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081
    Similarity: Contains 1 RGS domain


    RGS20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS20_HUMAN, O76081
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits,
    accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited
    by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated
    activation of the G-proteins (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI--
         
    RGS20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RGS20:
     Decreased number of cells in m 

         1 MGI phenotypic allele for Rgs20 (no phenotypes)

    RGS20 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS20
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    miRNA
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    hsa-mir-26b-5p (MIRT028834)

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    6 qRT-PCR Assays for microRNAs that regulate RGS20:
    hsa-miR-3065-5p hsa-miR-496 hsa-miR-4293 hsa-miR-218 hsa-miR-636 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidRGS20 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RGS20

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    GenScript: all cDNA clones in your preferred vector (see all 2): RGS20 (NM_170587)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS20

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGS20_HUMAN, O76081: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell
    membrane and the nucleus (By similarity). Anchored to the membrane through palmitoylation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane3
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--

    RGS20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS20 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    4Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    5ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS20
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    2 BioSystems Pathways for RGS20
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell

    2 Reactome Pathways for RGS20
        G alpha (i) signalling events
    G alpha (z) signalling events



    RGS20 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS20
    Interactions:

        GeneGlobe Interaction Network for RGS20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RGS20 (O760811, 2, 3 ENSP000002973134) via UniProtKB, MINT, STRING, and/or I2D (see all 158)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTNR1AP480391, 2, 3, ENSP000003028114EBI-1052678,EBI-1188238 MINT-8087198 MINT-8087089 MINT-8087146 MINT-8087131 MINT-8087181 MINT-8087038 MINT-8087164 I2D: score=1 STRING: ENSP00000302811
    MTNR1BP492861, 2, 3, ENSP000002570684EBI-1052678,EBI-1188341 MINT-8087055 MINT-8087089 I2D: score=1 STRING: ENSP00000257068
    ABL1P005192, 3, ENSP000003614234MINT-8110683 I2D: score=3 STRING: ENSP00000361423
    ENSG00000229802Q925043, ENSP000003917354I2D: score=2 STRING: ENSP00000391735
    SLC39A7Q925043, ENSP000003638074I2D: score=2 STRING: ENSP00000363807
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS9748279
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS9748279

    RGS20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS20

    2 Novoseek inferred chemical compound relationships for RGS20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 48.5 1 9748280 (1)
    phospholipid 42.4 2 9748280 (1)



    RGS20 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RGS20 gene (5 alternative transcripts): 
    NM_001286673.1  NM_001286674.1  NM_001286675.1  NM_003702.4  NM_170587.3  

    Unigene Cluster for RGS20:

    Regulator of G-protein signaling 20
    Hs.368733  [show with all ESTs]
    Unigene Representative Sequence: NM_170587
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297313(uc003xrp.3 uc003xrq.3 uc010lye.3 uc010lyf.3)
    ENST00000517659 ENST00000344277 ENST00000523280 ENST00000518286 ENST00000523414
    ENST00000522225(uc003xrt.3) ENST00000276500(uc003xrs.3) ENST00000523064(uc003xrr.2)
    ENST00000517405
    miRNA
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    hsa-miR-3065-5p hsa-miR-496 hsa-miR-4293 hsa-miR-218 hsa-miR-636 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidRGS20 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RGS20
      QuantiFast Probe-based Assays in human, mouse, rat RGS20

    Additional mRNA sequence: 

    AF060877.2 AF074979.1 AF366054.1 AF366055.1 AF366056.1 AF366057.1 AF493940.1 AK094503.1 
    AY046538.1 BC015614.2 BC018618.1 BC031328.1 BC054867.1 BC063490.1 JQ308180.1 

    10 DOTS entries:

    DT.409664  DT.95263258  DT.121474930  DT.95263260  DT.92028682  DT.99952419  DT.121474891  DT.121474902 
    DT.121474947  DT.97809650 

    Selected AceView cDNA sequences (see all 63):

    BF589264 AF493940 BC018618 BX281538 AF074979 AA626204 CR622266 CR594448 
    AL525981 BC031328 CB141523 BC063490 BU615460 AA450087 BC015614 BQ020924 
    AA242973 AI435005 BG760472 CR602987 N47280 AK094503 AA450144 AI264190 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RGS20 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:              -     -     -           -                                       
    SP2:        -     -     -     -           -                                       
    SP3:                          -           -                                       
    SP4:        -     -     -     -     -     -                                       
    SP5:                    -     -           -                                       


    ECgene alternative splicing isoforms for RGS20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACAACAA
    RGS20 Expression
    About this image


    RGS20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
    RGS20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368733

    UniProtKB/Swiss-Prot: RGS20_HUMAN, O76081
    Tissue specificity: Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe

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    QuantiFast Probe-based Assays in human, mouse, rat RGS20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGS20 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs201 , 5 regulator of G-protein signaling 201, 5 73.17(n)1
    65.85(a)1
      1 (1.80 cM)5
    581751  NM_001177795.11  NP_001171266.11 
     49095765 
    chicken
    (Gallus gallus)
    Aves RGS201 regulator of G-protein signaling 20 80.49(n)
    84.79(a)
      395646  NM_204842.2  NP_990173.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS206
    regulator of G-protein signaling 20
    74(a)
    1 ↔ 1
    GL343244.1(1186309-1213340)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rgs201 regulator of G-protein signaling 20 76.42(n)
    81.13(a)
      100158614  NM_001128030.1  NP_001121502.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.110712 Transcribed sequence with weak similarity to protein more 76.42(n)    BG307106.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:52C10.23 regulation of G-protein coupled
    receptor protein more
    61(a)   54E9   --
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-21 rgs-2 61.19(n)
    63.43(a)
      181414  NM_001029415.3  NP_001024586.1 


    ENSEMBL Gene Tree for RGS20 (if available)
    TreeFam Gene Tree for RGS20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS20 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS162  RGS172  RGS52  
    RGS12  RGS182  RGS132  RGS42  
    18 SIMAP similar genes for RGS20 using alignment to 5 protein entries:     RGS20_HUMAN (see all proteins):
    RGS17    RGS19    RGS21    RGS1    RGS9    RGS4
    RGS8    RGS10    RGS18    RGS2    RGS5    RGS6
    RGS3    RGS13    RGS11    RGS7    RGS16    AXIN2

    RGS20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS20 (see all 2129)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69943321,2
    C,A--54762380(+) attttG/Cttcta 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1840265951,2
    --54762395(+) TTTTAC/TAGTTT 1 -- us2k10--------
    rs1879661281,2
    --54762411(+) TTTATA/GTTTAA 1 -- us2k10--------
    rs1927091181,2
    --54762469(+) GGTCCA/GGTTTC 1 -- us2k10--------
    rs125487671,2
    H--54762509(+) ccaacA/Cccatt 1 -- us2k10--------
    rs122348881,2
    H--54762574(+) tttcaG/Aatttg 1 -- us2k14Minor allele frequency- A:0.00NS EA 400
    rs1845110141,2
    --54762848(+) CTGTAA/GCTTTG 1 -- us2k10--------
    rs1455639721,2
    --54762869(+) TAAAAC/TTGGGA 1 -- us2k10--------
    rs64738951,2
    C,F,H--54762904(+) ttatcG/Aagact 1 -- us2k129Minor allele frequency- A:0.04NS EA NA WA CSA 2544
    rs1488876301,2
    C--54762916(+) TTTTGA/GATATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGS20 (54764368 - 54871863 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RGS20:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737005CNV Deletion23290073
    essv22151CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS20
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607193    OMIM disorders: --

    4 diseases for RGS20:    
    About MalaCards
    bronchiolitis    hypertension    squamous cell carcinoma    malaria


    RGS20 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS20
    Human Genome Epidemiology (HuGE) Navigator: RGS20 (2 documents)

    Export disorders for RGS20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS20 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RGS20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily. (PubMed id 9748280)1, 2, 3, 9 Wang J.... Ross E.M. (J. Biol. Chem. 1998)
    2. RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. (PubMed id 9748279)1, 2, 3 Glick J.L.... Casey P.J. (J. Biol. Chem. 1998)
    3. RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. (PubMed id 11735229)1, 2, 9 Barker S.A.... Ross E.M. (Genomics 2001)
    4. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (Carcinogenesis 2010)
    5. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PubMed id 18360038)1, 4 Kohara K....Miki T. (Hypertens. Res. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling. (PubMed id 12379657)1, 2 Wang Y....Young K.H. (J. Biol. Chem. 2002)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Protein interactions of the transcription factor Hoxa1. (PubMed id 23088713)1 Lambert B....Rezsohazy R. (BMC Dev. Biol. 2012)
    10. Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways. (PubMed id 18407463)1 Pagano M....Iyengar R. (Cell. Signal. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8601 HGNC: 14600 AceView: RGS20 Ensembl:ENSG00000147509 euGenes: HUgn8601
    ECgene: RGS20 H-InvDB: RGS20

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RGS20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS20 gene:
    Search GeneIP for patents involving RGS20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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