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Aliases for RGS2 Gene

Aliases for RGS2 Gene

  • Regulator Of G-Protein Signaling 2 2 3
  • G0S8 3 4 6
  • Regulator Of G-Protein Signaling 2, 24kDa 2 3
  • Cell Growth-Inhibiting Gene 31 Protein 3 4
  • G0/G1 Switch Regulatory Protein 8 3 4
  • Regulator Of G-Protein Signalling 2, 24kDa 2
  • Regulator Of G-Protein Signalling 2, 24kD 2
  • G0 To G1 Switch Regulatory 8, 24kD 3
  • Cell Growth-Inhibiting Protein 31 3

External Ids for RGS2 Gene

Previous HGNC Symbols for RGS2 Gene

  • G0S8

Previous GeneCards Identifiers for RGS2 Gene

  • GC01P190568
  • GC01P188292
  • GC01P189244
  • GC01P190066
  • GC01P189509
  • GC01P191044
  • GC01P164013

Summaries for RGS2 Gene

Entrez Gene Summary for RGS2 Gene

  • Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

GeneCards Summary for RGS2 Gene

RGS2 (Regulator Of G-Protein Signaling 2) is a Protein Coding gene. Diseases associated with RGS2 include rieger syndrome, type 2 and syncope. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS2 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

Gene Wiki entry for RGS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS2 Gene

Genomics for RGS2 Gene

Regulatory Elements for RGS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGS2 Gene

Start:
192,809,039 bp from pter
End:
192,812,283 bp from pter
Size:
3,245 bases
Orientation:
Plus strand

Genomic View for RGS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS2 Gene

Proteins for RGS2 Gene

  • Protein details for RGS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41220-RGS2_HUMAN
    Recommended name:
    Regulator of G-protein signaling 2
    Protein Accession:
    P41220
    Secondary Accessions:
    • Q6I9U5

    Protein attributes for RGS2 Gene

    Size:
    211 amino acids
    Molecular mass:
    24382 Da
    Quaternary structure:
    • Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).

    Three dimensional structures from OCA and Proteopedia for RGS2 Gene

    Alternative splice isoforms for RGS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS2 Gene

Proteomics data for RGS2 Gene at MOPED

Post-translational modifications for RGS2 Gene

  • Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS2 Gene

Domains for RGS2 Gene

Gene Families for RGS2 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • RGS :Regulators of G-protein signaling

Protein Domains for RGS2 Gene

Suggested Antigen Peptide Sequences for RGS2 Gene

Graphical View of Domain Structure for InterPro Entry

P41220

UniProtKB/Swiss-Prot:

RGS2_HUMAN :
  • P41220
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS2: view

Function for RGS2 Gene

Molecular function for RGS2 Gene

GENATLAS Biochemistry: negative regulator of G-protein signaling 2,functioning as GTPase-activating protein for G protein alpha i and q subunits,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

Gene Ontology (GO) - Molecular Function for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 14608379
GO:0005516 calmodulin binding TAS 10747990
GO:0048487 beta-tubulin binding IEA --
genes like me logo Genes that share ontologies with RGS2: view
genes like me logo Genes that share phenotypes with RGS2: view

Animal Models for RGS2 Gene

MGI Knock Outs for RGS2:

Animal Model Products

CRISPR Products

miRNA for RGS2 Gene

miRTarBase miRNAs that target RGS2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RGS2 Gene

Localization for RGS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS2 Gene

Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 4: Cell membrane. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS2 Gene COMPARTMENTS Subcellular localization image for RGS2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10791963
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with RGS2: view

Pathways for RGS2 Gene

genes like me logo Genes that share pathways with RGS2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007049 cell cycle IEA --
GO:0007283 spermatogenesis IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10747990
GO:0010519 negative regulation of phospholipase activity ISS --
genes like me logo Genes that share ontologies with RGS2: view

Compounds for RGS2 Gene

(12) Novoseek inferred chemical compound relationships for RGS2 Gene

Compound -log(P) Hits PubMed IDs
go 6976 62.3 2
gtp 48.4 1
carbachol 42.1 8
forskolin 42 7
phosphoinositide 38.1 9

(1) PharmGKB related drug/compound annotations for RGS2 Gene

Drug/compound Annotation
antipsychotics CA
genes like me logo Genes that share compounds with RGS2: view

Transcripts for RGS2 Gene

mRNA/cDNA for RGS2 Gene

Unigene Clusters for RGS2 Gene

Regulator of G-protein signaling 2, 24kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for RGS2 Gene

GeneLoc Exon Structure for
RGS2
ECgene alternative splicing isoforms for
RGS2

Expression for RGS2 Gene

mRNA expression in normal human tissues for RGS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS2 Gene

This gene is overexpressed in Whole Blood (8.2) and Esophagus - Muscularis (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGS2 Gene

SOURCE GeneReport for Unigene cluster for RGS2 Gene Hs.78944

mRNA Expression by UniProt/SwissProt for RGS2 Gene

P41220-RGS2_HUMAN
Tissue specificity: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
genes like me logo Genes that share expressions with RGS2: view

In Situ Assay Products

Orthologs for RGS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS2 35
  • 99.21 (n)
  • 99.53 (a)
RGS2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS2 35
  • 91.91 (n)
  • 94.06 (a)
RGS2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs2 35
  • 89.42 (n)
  • 96.21 (a)
Rgs2 16
Rgs2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs2 35
  • 89.57 (n)
  • 96.68 (a)
chicken
(Gallus gallus)
Aves RGS2 35
  • 70.49 (n)
  • 72.25 (a)
RGS2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS2 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.27466 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs2 35
  • 70.62 (n)
  • 69.19 (a)
Str.15616 35
zebrafish
(Danio rerio)
Actinopterygii rgs2 36
  • 39 (a)
OneToOne
Species with no ortholog for RGS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS2 Gene

ENSEMBL:
Gene Tree for RGS2 (if available)
TreeFam:
Gene Tree for RGS2 (if available)

Paralogs for RGS2 Gene

Paralogs for RGS2 Gene

Selected SIMAP similar genes for RGS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS2: view

Variants for RGS2 Gene

Sequence variations from dbSNP and Humsavar for RGS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4606 -- 192,812,042(+) TGCAA(C/G)GGTAT utr-variant-3-prime
rs11423 -- 192,812,042(+) GCAAG(A/G)GTATT utr-variant-3-prime
rs756409 -- 192,811,209(-) TTACT(C/G/T)TGTTT intron-variant
rs1418718 -- 192,807,284(+) ACTGG(A/G)TAAGC upstream-variant-2KB
rs1418719 -- 192,807,542(+) CATAG(C/G)AGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RGS2 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990

Relevant External Links for RGS2 Gene

HapMap Linkage Disequilibrium report
RGS2
Human Gene Mutation Database (HGMD)
RGS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS2 Gene

Disorders for RGS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for RGS2 Gene including...

Search for RGS2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for RGS2 Gene

(3) Novoseek inferred disease relationships for RGS2 Gene

Disease -log(P) Hits PubMed IDs
hypertrophy 13.1 9
astrocytoma 12.9 3
shock 0 5

Relevant External Links for RGS2

Genetic Association Database (GAD)
RGS2
Human Genome Epidemiology (HuGE) Navigator
RGS2
genes like me logo Genes that share disorders with RGS2: view

No data available for UniProtKB/Swiss-Prot for RGS2 Gene

Publications for RGS2 Gene

  1. Mechanisms governing subcellular localization and function of human RGS2. (PMID: 11278586) Heximer S.P. … Blumer K.J. (J. Biol. Chem. 2001) 3 4 23
  2. Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population. (PMID: 16003176) Yang J. … Miyata T. (J. Hypertens. 2005) 3 23 48
  3. Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. (PMID: 16432041) Riddle E.L. … Insel P.A. (Hypertension 2006) 3 23 48
  4. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. (PMID: 16691626) Gu J. … Berman D.M. (Cancer 2006) 3 23 48
  5. -391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies. (PMID: 17143182) Freson K. … Van Geet C. (J. Hypertens. 2007) 3 23 48

Products for RGS2 Gene

Sources for RGS2 Gene

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