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RGS2 Gene

protein-coding   GIFtS: 68
GCID: GC01P192778

Regulator Of G-Protein Signaling 2, 24kDa

(Previous names: regulator of G-protein signalling 2, 24kD, regulator of...)
(Previous symbol: G0S8)
  See RGS2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Regulator Of G-Protein Signaling 2, 24kDa1 2     Regulator Of G-Protein Signalling 2, 24kDa1
G0S81 2 3 5     Cell Growth-Inhibiting Protein 312
Cell Growth-Inhibiting Gene 31 Protein2 3     G0 To G1 Switch Regulatory 8, 24kD2
G0/G1 Switch Regulatory Protein 82 3     Regulator Of G-Protein Signaling 22
Regulator Of G-Protein Signalling 2, 24kD1     

External Ids:    HGNC: 99981   Entrez Gene: 59972   Ensembl: ENSG000001167417   OMIM: 6008615   UniProtKB: P412203   
ORGUL members:         

Export aliases for RGS2 gene to outside databases

Previous GC identifers: GC01P190568 GC01P188292 GC01P189244 GC01P190066 GC01P189509 GC01P191044 GC01P164013


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS2 Gene:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating
proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein
subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound
forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid
differentiation and may play a role in leukemogenesis. (provided by RefSeq, Aug 2009)

GeneCards Summary for RGS2 Gene:
RGS2 (regulator of G-protein signaling 2, 24kDa) is a protein-coding gene. Diseases associated with RGS2 include axenfeld-rieger syndrome type 2, and syncope. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS8.

UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative
feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting
the translation of mRNA into protein

Gene Wiki entry for RGS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS2 gene promoter:
         AREB6   SRF   C/EBPbeta   SRF (504 AA)   HSF1 (long)   HSF1short   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS2 promoter sequence
   Search Chromatin IP Primers for RGS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31

RGS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P192778:  view genomic region     (about GC identifiers)

Start:
192,778,169 bp from pter      End:
192,781,407 bp from pter
Size:
3,239 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 2  
Size: 211 amino acids; 24382 Da
Subunit: Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha)
4 PDB 3D structures from and Proteopedia for RGS2:
2AF0 (3D)        2V4Z (3D)        4EKC (3D)        4EKD (3D)    
Secondary accessions: Q6I9U5
Alternative initiation: 4 isoforms:  P41220-1   P41220-2   P41220-3   P41220-4   (Lacks type V adenylyl cyclase (AC) inhibitory function)

Explore the universe of human proteins at neXtProt for RGS2: NX_P41220

Explore proteomics data for RGS2 at MOPED

Post-translational modifications: 

  • Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002914.1  
    ENSEMBL proteins: 
     ENSP00000235382  
    Reactome Protein details: P41220

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    antibodies-online peptides for RGS2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry P41220

    ProtoNet protein and cluster: P41220

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220
    Similarity: Contains 1 RGS domain


    Find genes that share domains with RGS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS2_HUMAN, P41220
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative
    feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting
    the translation of mRNA into protein

         Genatlas biochemistry entry for RGS2:
    negative regulator of G-protein signaling 2,functioning as GTPase-activating protein for G protein alpha i and q
    subunits,C elegans EGL-10 and yeast SST2 homolog

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI14608379
    GO:0005516calmodulin binding TAS10747990
    GO:0048487beta-tubulin binding IEA--
         
    Find genes that share ontologies with RGS2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RGS2:
     Increased gamma-H2AX phosphory  Increased mitotic index 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Rgs2):
     behavior/neurological  cardiovascular system  hematopoietic system  immune system  muscle 
     nervous system  no phenotypic analysis  normal  renal/urinary system 

    Find genes that share phenotypes with RGS2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgs2tm1Pngr for RGS2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RGS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGS2

    miRNA
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    hsa-mir-22-3p (MIRT005903)

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    Selected qRT-PCR Assays for microRNAs that regulate RGS2 (see all 13):
    hsa-miR-22 hsa-miR-30c hsa-miR-148b* hsa-miR-513a-3p hsa-miR-4272 hsa-miR-1271 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidRGS2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGS2_HUMAN, P41220: Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus
    RGS2_HUMAN, P41220: Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus
    RGS2_HUMAN, P41220: Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus
    RGS2_HUMAN, P41220: Isoform 4: Cell membrane. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    plasma membrane5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane IBA--

    Find genes that share ontologies with RGS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    4Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    5Activation of cAMP-Dependent PKA
    cAMP Pathway0.77


    Find genes that share SuperPaths with RGS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS2
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    2 GeneGo (Thomson Reuters) Pathways for RGS2
        G-protein signaling G-Protein alpha-s signaling cascades
    G-protein signaling G-Protein alpha-q signaling cascades

    2 BioSystems Pathways for RGS2
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell


    1 Reactome Pathway for RGS2
        G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for RGS2):
        Oxytocin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RGS2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RGS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RGS2 (P412201, 2, 3 ENSP000002353824) via UniProtKB, MINT, STRING, and/or I2D (see all 187)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R9AQ9ULJ81, 2, 3, ENSP000003445244EBI-712388,EBI-2515561 MINT-4953405 MINT-4953445 MINT-4953420 I2D: score=1 STRING: ENSP00000344524
    ENSG00000234078Q083452, 3, ENSP000004013974MINT-8268735 MINT-63731 I2D: score=5 STRING: ENSP00000401397
    DDR1Q083452, 3MINT-8268735 MINT-63731 I2D: score=5 
    ENSG00000137332Q083452, 3MINT-8268735 MINT-63731 I2D: score=5 
    ENSG00000215522Q083452, 3MINT-8268735 MINT-63731 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0007049cell cycle IEA--
    GO:0007283spermatogenesis IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS10747990
    GO:0010519negative regulation of phospholipase activity ISS--

    Find genes that share ontologies with RGS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS2

    Selected Novoseek inferred chemical compound relationships for RGS2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    go 6976 62.3 2 16441551 (1), 10514440 (1)
    gtp 48.4 1 15173220 (1)
    carbachol 42.1 9 10514440 (4), 11755214 (2), 11322774 (1), 12181442 (1)
    forskolin 42 9 15914115 (2), 11832360 (1), 12603835 (1), 16756988 (1) (see all 6)
    phosphoinositide 38.1 12 10514440 (4), 11755214 (2), 10567399 (1), 14976183 (1) (see all 5)
    actinomycin d 34.5 3 15914115 (1), 10692485 (1), 10514440 (1)
    quinpirole 32.6 2 17179741 (1), 12603835 (1)
    cyclic amp 14.1 4 11755214 (2), 10514440 (1)
    calcium 11.2 20 15383626 (5), 11018106 (2), 9174164 (2), 16627589 (1) (see all 9)
    adenylate 10.3 1 12603835 (1)

    1 PharmGKB related drug/compound annotation for RGS2 gene    About this table
    Drug/compound PharmGKB Annotation
    antipsychoticsCA  



    Find genes that share compounds with RGS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGS2 gene: 
    NM_002923.3  

    Unigene Cluster for RGS2:

    Regulator of G-protein signaling 2, 24kDa
    Hs.78944  [show with all ESTs]
    Unigene Representative Sequence: BC042755
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483295 ENST00000235382(uc001gsl.3) ENST00000464302 ENST00000487236

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    Additional mRNA sequence: 

    AF493926.1 AK313668.1 AY971351.1 BC007049.1 BC042755.1 BC044742.1 BT007065.1 CR457410.1 
    L13463.1 

    7 DOTS entries:

    DT.100808212  DT.100707690  DT.121410356  DT.121410362  DT.91692879  DT.121410366  DT.95150983 

    Selected AceView cDNA sequences (see all 315):

    BQ221769 CD679596 AA370404 AA582633 BI829628 AA922770 AI582934 CK906131 
    BC042755 CR598258 AI950611 BI761507 CD676442 BM682599 AI185343 AW139656 
    CR595811 BU683574 CR619003 CD677227 CA447649 BC044742 BQ447499 AW779721 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RGS2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                    -                     
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for RGS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGCTAAA
    RGS2 Expression
    About this image


    RGS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Epithalamus
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem MEL2, NCr-fac Progenitor
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
    RGS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78944

    UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220
    Tissue specificity: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RGS2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Synaptic Plasticity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RGS2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs21 , 5 regulator of G-protein signaling 21, 5 89.42(n)1
    96.21(a)1
      1 (62.56 cM)5
    197351  NM_009061.41  NP_033087.21 
     1439993385 
    chicken
    (Gallus gallus)
    Aves RGS21 regulator of G-protein signaling 2, 24kDa 70.49(n)
    72.25(a)
      378912  NM_204395.2  NP_989726.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS26
    regulator of G-protein signaling 2, 24kDa
    75(a)
    1 ↔ 1
    GL343267.1(1403842-1409323)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.274662 Xenopus laevis mRNA for regulators of G protein signaling more 80.95(n)    AB038439.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570885542   -- 80.02(n)    57088554 


    ENSEMBL Gene Tree for RGS2 (if available)
    TreeFam Gene Tree for RGS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS2 gene
    RGS82  RGS192  RGS212  RGS32  RGS202  RGS162  RGS172  RGS52  
    RGS12  RGS182  RGS132  RGS42  
    17 SIMAP similar genes for RGS2 using alignment to 2 protein entries:     RGS2_HUMAN (see all proteins):
    RGS3    RGS21    RGS4    RGS8    RGS16    RGS13
    RGS19    RGS20    RGS6    RGS5    RGS1    RGS18
    RGS10    RGS17    RGS9    RGS14    RGS7

    Find genes that share paralogs with RGS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS2 (see all 167)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744664251,2
    Cuntested1199316908(+) GACAAG/CAGCGC 2 /N /K mis11Minor allele frequency- C:0.00NA 4550
    rs7564091,2
    C--164016145(-) TTACTC/G/TTGTTT 1 -- int12NA MN 264
    rs30532261,2
    C--192780089(+) GCTCT-/CTTTTCT 1 -- int12Minor allele frequency- CT:0.25NA CSA 4
    rs57796531,2
    C--192780089(+) GCATG-/C/CT  
            
    CTCTT
    1 -- int1 trp30--------
    rs2017098651,2
    C--192780093(+) GCTCTC/TTTTTC 1 -- int10--------
    rs105984281,2
    C--192780338(+) GAAAC-/AAAGTAA 1 -- int10--------
    rs616886451,2
    C--192781643(+) AAAAAA/-TCAAG 1 -- ds50012Minor allele frequency- -:0.00NA CSA 4
    rs1156622571,2
    F--199314827(+) ATCCTC/TGTACG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1919106051,2
    --199314834(+) TACGAC/TTTTTT 1 -- us2k10--------
    rs1112397241,2
    C--199314941(+) CTTTCA/GTGTAA 1 -- us2k12Minor allele frequency- G:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for RGS2 (192778169 - 192781407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RGS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv466994CNV Loss19166990

    Human Gene Mutation Database (HGMD): RGS2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS2
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600861    OMIM disorders: --

    3 diseases for RGS2:    
    About MalaCards
    axenfeld-rieger syndrome type 2    syncope    generalized anxiety disorder

    2 diseases from the University of Copenhagen DISEASES database for RGS2:
    Hypertension     Panic disorder

    Find genes that share disorders with RGS2           About GenesLikeMe

    3 Novoseek inferred disease relationships for RGS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertrophy 13.1 12 20362664 (4), 16380388 (3), 18207159 (2)
    astrocytoma 12.9 3 11488592 (2), 11755214 (1)
    shock 0 5 11488592 (2), 11322774 (2), 16733081 (1)

    Genetic Association Database (GAD): RGS2
    Human Genome Epidemiology (HuGE) Navigator: RGS2 (40 documents)

    Export disorders for RGS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS2 gene, integrated from 10 sources (see all 182):
    (articles sorted by number of sources associating them with RGS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells. (PubMed id 8179820)1, 2, 3 Siderovski D.P.... Forsdyke D.R. (DNA Cell Biol. 1994)
    2. Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims. (PubMed id 17728697)1, 4, 9 Cui H....Shirakawa O. (Neuropsychopharmacology 2008)
    3. Mechanisms governing subcellular localization and function of human RGS2. (PubMed id 11278586)1, 2, 9 Heximer S.P.... Blumer K.J. (J. Biol. Chem. 2001)
    4. Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: protective role of a functional polymorphism in the 3'-untranslated region. (PubMed id 18347610)1, 4, 9 Greenbaum L....Lerer B. (Pharmacogenomics J. 2009)
    5. Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins. (PubMed id 17901199)1, 2, 9 Gu S.... Heximer S.P. (Mol. Pharmacol. 2008)
    6. Association analysis between functional polymorphism of the rs4606 SNP in the RGS2 gene and antipsychotic-induced Parkinsonism in Japanese patients with schizophrenia: results from the Juntendo University Schizophrenia Projects (JUSP). (PubMed id 19931593)1, 4, 9 Higa M....Arai H. (Neurosci. Lett. 2010)
    7. Are RGS2 gene polymorphisms associated with high blood pressure in an ethnicity- and gender-specific manner? (PubMed id 19023274)1, 4, 9 Hahntow I.N....Michel M.C. (Am. J. Hypertens. 2009)
    8. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PubMed id 18262772)1, 4, 9 Campbell D.B....Sullivan P.F. (Schizophr. Res. 2008)
    9. -391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies. (PubMed id 17143182)1, 4, 9 Freson K....Van Geet C. (J. Hypertens. 2007)
    10. RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. (PubMed id 18833580)1, 4, 9 Koenen K.C....Gelernter J. (Depress Anxiety 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5997 HGNC: 9998 AceView: RGS2 Ensembl:ENSG00000116741 euGenes: HUgn5997
    ECgene: RGS2 Kegg: 5997 H-InvDB: RGS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS2 gene:
    Search GeneIP for patents involving RGS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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