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Aliases for RGS2 Gene

Aliases for RGS2 Gene

  • Regulator Of G-Protein Signaling 2 2 3 5
  • Regulator Of G-Protein Signaling 2, 24kDa 2 3
  • Cell Growth-Inhibiting Gene 31 Protein 3 4
  • G0/G1 Switch Regulatory Protein 8 3 4
  • G0S8 3 4
  • Regulator Of G-Protein Signalling 2, 24kDa 2
  • Regulator Of G-Protein Signalling 2, 24kD 2
  • G0 To G1 Switch Regulatory 8, 24kD 3
  • Cell Growth-Inhibiting Protein 31 3

External Ids for RGS2 Gene

Previous HGNC Symbols for RGS2 Gene

  • G0S8

Previous GeneCards Identifiers for RGS2 Gene

  • GC01P190568
  • GC01P188292
  • GC01P189244
  • GC01P190066
  • GC01P189509
  • GC01P191044
  • GC01P164013

Summaries for RGS2 Gene

Entrez Gene Summary for RGS2 Gene

  • Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

GeneCards Summary for RGS2 Gene

RGS2 (Regulator Of G-Protein Signaling 2) is a Protein Coding gene. Diseases associated with RGS2 include rieger syndrome, type 2 and c5 deficiency. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include GTPase activator activity and beta-tubulin binding. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS2 Gene

  • Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).

Gene Wiki entry for RGS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS2 Gene

Genomics for RGS2 Gene

Regulatory Elements for RGS2 Gene

Promoters for RGS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS2 Gene

Chromosome:
1
Start:
192,809,039 bp from pter
End:
192,812,283 bp from pter
Size:
3,245 bases
Orientation:
Plus strand

Genomic View for RGS2 Gene

Genes around RGS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS2 Gene

Proteins for RGS2 Gene

  • Protein details for RGS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41220-RGS2_HUMAN
    Recommended name:
    Regulator of G-protein signaling 2
    Protein Accession:
    P41220
    Secondary Accessions:
    • Q6I9U5

    Protein attributes for RGS2 Gene

    Size:
    211 amino acids
    Molecular mass:
    24382 Da
    Quaternary structure:
    • Interacts with GNAQ (PubMed:18434541, PubMed:19478087). Does not interact with GNAI1 and GNAI3 (PubMed:18434541, PubMed:19478087). Interacts with EIF2B5 (PubMed:19736320). Interacts with PRKG1 (isoform alpha) (PubMed:14608379).

    Three dimensional structures from OCA and Proteopedia for RGS2 Gene

    Alternative splice isoforms for RGS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS2 Gene

Proteomics data for RGS2 Gene at MOPED

Post-translational modifications for RGS2 Gene

  • Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RGS2 Gene

Domains & Families for RGS2 Gene

Protein Domains for RGS2 Gene

Suggested Antigen Peptide Sequences for RGS2 Gene

Graphical View of Domain Structure for InterPro Entry

P41220

UniProtKB/Swiss-Prot:

RGS2_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS2: view

Function for RGS2 Gene

Molecular function for RGS2 Gene

GENATLAS Biochemistry:
negative regulator of G-protein signaling 2,functioning as GTPase-activating protein for G protein alpha i and q subunits,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).

Gene Ontology (GO) - Molecular Function for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 19478087
genes like me logo Genes that share ontologies with RGS2: view
genes like me logo Genes that share phenotypes with RGS2: view

Animal Models for RGS2 Gene

MGI Knock Outs for RGS2:

Animal Model Products

miRNA for RGS2 Gene

miRTarBase miRNAs that target RGS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS2 Gene

Localization for RGS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS2 Gene

Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus.
Isoform 4: Cell membrane. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS2 Gene COMPARTMENTS Subcellular localization image for RGS2 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
mitochondrion 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with RGS2: view

Pathways & Interactions for RGS2 Gene

genes like me logo Genes that share pathways with RGS2: view

Gene Ontology (GO) - Biological Process for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0010519 negative regulation of phospholipase activity IEA,ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy IEA,ISS --
GO:0031116 positive regulation of microtubule polymerization IEA --
GO:0043407 negative regulation of MAP kinase activity IEA,ISS --
genes like me logo Genes that share ontologies with RGS2: view

No data available for SIGNOR curated interactions for RGS2 Gene

Drugs & Compounds for RGS2 Gene

(9) Drugs for RGS2 Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
antipsychotics Pharma 0

(4) Additional Compounds for RGS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS2: view

Transcripts for RGS2 Gene

Unigene Clusters for RGS2 Gene

Regulator of G-protein signaling 2, 24kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for RGS2 Gene

GeneLoc Exon Structure for
RGS2
ECgene alternative splicing isoforms for
RGS2

Expression for RGS2 Gene

mRNA expression in normal human tissues for RGS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS2 Gene

This gene is overexpressed in Whole Blood (x8.2) and Esophagus - Muscularis (x5.1).

Protein differential expression in normal tissues from HIPED for RGS2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS2 Gene



SOURCE GeneReport for Unigene cluster for RGS2 Gene Hs.78944

mRNA Expression by UniProt/SwissProt for RGS2 Gene

P41220-RGS2_HUMAN
Tissue specificity: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
genes like me logo Genes that share expression patterns with RGS2: view

Protein tissue co-expression partners for RGS2 Gene

Primer Products

In Situ Assay Products

Orthologs for RGS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RGS2 35
  • 91.91 (n)
  • 94.06 (a)
RGS2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs2 35
  • 89.42 (n)
  • 96.21 (a)
Rgs2 16
Rgs2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS2 35
  • 99.21 (n)
  • 99.53 (a)
RGS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs2 35
  • 89.57 (n)
  • 96.68 (a)
cow
(Bos Taurus)
Mammalia RGS2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS2 35
  • 70.49 (n)
  • 72.25 (a)
RGS2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs2 35
  • 70.62 (n)
  • 69.19 (a)
Str.15616 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.27466 35
zebrafish
(Danio rerio)
Actinopterygii rgs2 36
  • 39 (a)
OneToOne
Species with no ortholog for RGS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS2 Gene

ENSEMBL:
Gene Tree for RGS2 (if available)
TreeFam:
Gene Tree for RGS2 (if available)

Paralogs for RGS2 Gene

Paralogs for RGS2 Gene

(17) SIMAP similar genes for RGS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS2: view

Variants for RGS2 Gene

Sequence variations from dbSNP and Humsavar for RGS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4606 -- 192,812,042(+) TGCAA(C/G/T)GGTAT utr-variant-3-prime
rs756409 -- 192,811,209(-) TTACT(C/G/T)TGTTT intron-variant
rs1418718 -- 192,807,284(+) ACTGG(A/G)TAAGC upstream-variant-2KB
rs1418719 -- 192,807,542(+) CATAG(C/G)AGAGG upstream-variant-2KB
rs2746071 -- 192,808,434(+) TCCCC(A/G)TTGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RGS2 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990

Variation tolerance for RGS2 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS2 Gene

HapMap Linkage Disequilibrium report
RGS2
Human Gene Mutation Database (HGMD)
RGS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS2 Gene

Disorders for RGS2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RGS2 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
rieger syndrome, type 2
  • axenfeld-rieger syndrome type 2
c5 deficiency
  • complement component 5 deficiency
generalized anxiety disorder
  • anxiety generalized
phobic disorder
  • phobic anxiety disorder
gitelman syndrome
  • hypomagnesemia-hypokalemia, primary renotubular, with hypocalciuria
- elite association - COSMIC cancer census association via MalaCards
Search RGS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGS2

Genetic Association Database (GAD)
RGS2
Human Genome Epidemiology (HuGE) Navigator
RGS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS2
genes like me logo Genes that share disorders with RGS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS2 Gene

Publications for RGS2 Gene

  1. A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells. (PMID: 8179820) Siderovski D.P. … Forsdyke D.R. (DNA Cell Biol. 1994) 2 3 4 67
  2. Genomic assessment of follicular marker genes as pregnancy predictors for human IVF. (PMID: 19778949) Hamel M. … Sirard M.A. (Mol. Hum. Reprod. 2010) 3 23
  3. Association analysis between functional polymorphism of the rs4606 SNP in the RGS2 gene and antipsychotic-induced Parkinsonism in Japanese patients with schizophrenia: results from the Juntendo University Schizophrenia Projects (JUSP). (PMID: 19931593) Higa M. … Arai H. (Neurosci. Lett. 2010) 3 23
  4. RGS2 expression and aldosterone: renin ratio modulate response to drug therapy in hypertensive patients. (PMID: 20375904) Semplicini A. … Ceolotto G. (J. Hypertens. 2010) 3 23
  5. [Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population]. (PMID: 20140863) Zhang J. … Chang J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2010) 3 23

Products for RGS2 Gene

Sources for RGS2 Gene

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