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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS2 Gene

protein-coding   GIFtS: 65
GCID: GC01P192778

regulator of G-protein signaling 2, 24kDa

(Previous names: regulator of G-protein signalling 2, 24kD, regulator of...)
(Previous symbol: G0S8)
 Explore 36 diseases affiliated with
RGS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGS2    

Aliases
for RGS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of G-Protein Signaling 2, 24kDa1 2     Regulator Of G-Protein Signalling 2, 24kDa1
G0S81 2 3 5     Cell Growth-Inhibiting Protein 312
Cell Growth-Inhibiting Gene 31 Protein2 3     G0 To G1 Switch Regulatory 8, 24kD2
G0/G1 Switch Regulatory Protein 82 3     Regulator Of G-Protein Signaling 22
Regulator Of G-Protein Signalling 2, 24kD1     

External Ids:    HGNC: 99981   Entrez Gene: 59972   Ensembl: ENSG000001167417   OMIM: 6008615   UniProtKB: P412203   

Export aliases for RGS2 gene to outside databases

Previous GC identifers: GC01P190568 GC01P188292 GC01P189244 GC01P190066 GC01P189509 GC01P191044 GC01P164013


Summaries
for RGS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RGS2:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins
(GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of
the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of
G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a
role in leukemogenesis. (provided by RefSeq, Aug 2009)

UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control
pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of
mRNA into protein

Gene Wiki entry for RGS2


Genomic Views
for RGS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS2 gene promoter:
         AREB6   SRF   C/EBPbeta   SRF (504 AA)   HSF1 (long)   HSF1short   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31

RGS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P192778:  view genomic region     (about GC identifiers)

Start:
 192,778,169 bp from pter      End:
 192,781,407 bp from pter
Size:
 3,239 bases      Orientation:
 plus strand

Proteins
for RGS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 2  
Size: 211 amino acids; 24382 Da
Subunit: Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha)
Subcellular location: Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus
Subcellular location: Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus
Subcellular location: Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus
Subcellular location: Isoform 4: Cell membrane. Mitochondrion
4 PDB 3D structures from and Proteopedia for RGS2:
2AF0 (3D)        2V4Z (3D)        4EKC (3D)        4EKD (3D)    
Secondary accessions: Q6I9U5
Alternative initiation: 4 isoforms:  P41220-1   P41220-2   P41220-3   P41220-4   (Lacks type V adenylyl cyclase (AC) inhibitory function)

Explore the universe of human proteins at neXtProt for RGS2: NX_P41220

Post-translational modifications:

  • Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41220

    • RGS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002914.1  
    ENSEMBL proteins: 
     ENSP00000235382  

    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for RGS2
    Uscn Proteins for RGS2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane IBA--


    RGS2 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for RGS2

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    Uscn ELISAs and CLIAs for RGS2

    Protein Domains /
    Families
    for RGS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RGS2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry P41220

    ProtoNet protein and cluster: P41220

    1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220
    Similarity: Contains 1 RGS domain


    Function
    for RGS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
    them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control
    pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of
    mRNA into protein

         Genatlas biochemistry entry for RGS2:
    negative regulator of G-protein signaling 2,functioning as GTPase-activating protein for G protein alpha i and q
    subunits,C elegans EGL-10 and yeast SST2 homolog

    miRNA
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    hsa-mir-22 (MIRT005903)

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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RGS2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS2 (see all 13):
    hsa-miR-22 hsa-miR-30c hsa-miR-148b* hsa-miR-513a-3p hsa-miR-4272 hsa-miR-1271 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: RGS2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: RGS2
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI14608379
    GO:0005516calmodulin binding TAS10747990


    RGS2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RGS2:
     Increased gamma-H2AX phosphory  Increased mitotic index 

    Animal Models:
         Mouse knock-out Rgs2tm1Pngr for RGS2
         10 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Rgs2):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  immune system 
     muscle  nervous system  no phenotypic analysis  normal  renal/urinary system 

    RGS2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RGS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-AlphaQ Signaling
    		G-AlphaQ Signaling1.00
    		G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    		Calcium Regulation in the Cardiac Cell1.00
    		Myometrial Relaxation and Contraction Pathways0.43
    3Development_A3 receptor signaling
    		G-protein signaling_G-Protein alpha-q signaling cascades0.53
    		G-protein signaling G-Protein alpha-q signaling cascades0.53
    4G-protein signaling_G-Protein alpha-i signaling cascades
    		G-protein signaling G-Protein alpha-s signaling cascades0.44
    		G-protein signaling_G-Protein alpha-s signaling cascades0.44
    5Activation of cAMP-Dependent PKA
    		cAMP Pathway0.77

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for RGS2
        G-protein signaling G-Protein alpha-s signaling cascades
    G-protein signaling G-Protein alpha-q signaling cascades

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS2
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    2 GeneGo (Thomson Reuters) Pathways for RGS2
        G-protein signaling G-Protein alpha-s signaling cascades
    G-protein signaling G-Protein alpha-q signaling cascades

    2 BioSystems Pathways for RGS2 
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell



    RGS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for RGS2 (P412202, 3 ENSP000002353824) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VPS29Q9UBQ02, 3, ENSP000003807954MINT-63737 MINT-8268977 I2D: score=5 STRING: ENSP00000380795
    ARFGAP1Q8N6T32, 3, ENSP000003146154MINT-63734 I2D: score=5 STRING: ENSP00000314615
    CTSBP078582, 3MINT-8268724 MINT-63727 I2D: score=5 
    DDR1Q083452, 3MINT-8268735 MINT-63731 I2D: score=5 
    GIT1Q9Y2X72, 3MINT-8268779 MINT-63738 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0007049cell cycle IEA--
    GO:0007283spermatogenesis IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS10747990
    GO:0010519negative regulation of phospholipase activity ISS--


    RGS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS2
    10/12 Novoseek chemical compound relationships for RGS2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    go 6976 62.3 2 16441551 (1), 10514440 (1)
    gtp 48.4 1 15173220 (1)
    carbachol 42.1 9 10514440 (4), 11755214 (2), 11322774 (1), 12181442 (1)
    forskolin 42 9 15914115 (2), 11832360 (1), 12603835 (1), 16756988 (1) (see all 6)
    phosphoinositide 38.1 12 10514440 (4), 11755214 (2), 10567399 (1), 14976183 (1) (see all 5)
    actinomycin d 34.5 3 15914115 (1), 10692485 (1), 10514440 (1)
    quinpirole 32.6 2 17179741 (1), 12603835 (1)
    cyclic amp 14.1 4 11755214 (2), 10514440 (1)
    calcium 11.2 20 15383626 (5), 11018106 (2), 9174164 (2), 16627589 (1) (see all 9)
    adenylate 10.3 1 12603835 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS2 

    Transcripts
    for RGS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGS2 gene: 
    NM_002923.3  

    Unigene Cluster for RGS2:

    Regulator of G-protein signaling 2, 24kDa
    Hs.78944  [show with all ESTs]
    Unigene Representative Sequence: BC042755
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483295 ENST00000235382(uc001gsl.3) ENST00000464302 ENST00000487236


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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS2 (see all 13):
    hsa-miR-22 hsa-miR-30c hsa-miR-148b* hsa-miR-513a-3p hsa-miR-4272 hsa-miR-1271 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: RGS2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF493926.1 AK313668.1 AY971351.1 BC007049.1 BC042755.1 BC044742.1 BT007065.1 CR457410.1 
    L13463.1 

    7 DOTS entries:

    DT.100808212  DT.100707690  DT.121410356  DT.121410362  DT.91692879  DT.121410366  DT.95150983 

    24/315 AceView cDNA sequences (see all 315):

    AL036629 CR598258 CD676824 CK906131 AW139656 BU607685 AW006543 CA777687 
    BI761507 BQ014442 F09473 F02032 CA393645 BM055330 BE500956 CD676442 
    CD679596 BE811115 BI488607 BM142046 CR595811 AI185343 BQ008919 AW594212 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RGS2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                    -                     
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for RGS2

    Expression
    for RGS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATGCTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RGS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    AdiposeThoracic Perivascular AdiposeAdipose
    BrainEpithalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Posterior foregut-like cells (A scalable, suspensi...)
    Alveolar type II cells (Derivation of mature...)Lung

    See RGS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS2

    SOURCE GeneReport for Unigene cluster: Hs.78944

    UniProtKB/Swiss-Prot: RGS2_HUMAN, P41220
    Tissue specificity: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL)

        SABiosciences Expression via Pathway-Focused PCR Arrays including RGS2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Synaptic Plasticity in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS2

    Orthologs
    for RGS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RGS2 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RGS21 regulator of G-protein signaling 2, 24kDa 69.98(n)
    71.09(a)    		   378912  NM_204395.1  NP_989726.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RGS26
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343267.1(1405145-1409329)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.274662 Xenopus laevis mRNA for regulators of G protein signaling more 80.95(n)    AB038439.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570885542   -- 80.02(n)    57088554 
    worm
    (Caenorhabditis elegans)    		 Secernentea rgs-76
    rgs-46
    		 Regulator of G-protein signaling rgs-7
    Regulator of G protein Signaling family member (rg...
    		 7(a)
    22(a)
    		 1 ↔ many
    possible ortholog
    		 X(3542545-3557581)
    II(12667632-12671556)


    ENSEMBL Gene Tree for RGS2 (if available)
    TreeFam Gene Tree for RGS2 (if available) 

    Paralogs
    for RGS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS2 gene
    RGS82  RGS192  RGS212  RGS32  RGS162  RGS202  RGS52  RGS172  
    RGS12  RGS182  RGS42  RGS132  
    17 SIMAP similar genes for RGS2 using alignment to 2 protein entries:     RGS2_HUMAN (see all proteins):
    RGS3    RGS21    RGS4    RGS8    RGS16    RGS13
    RGS19    RGS20    RGS5    RGS6    RGS1    RGS18
    RGS10    RGS17    RGS9    RGS14    RGS7

    RGS2 for paralogs           About GeneDecksing



    Genomic Variants
    for RGS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/133 NCBI SNPs in RGS2 are shown (see all 133)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs744664251,2
    		C,untested190196437(+) GACAAG/CAGCGC 2 /N /K mis11Minor allele frequency- C:0.00NA 4550
    rs1112397241,2
    		C,--164012096(+) CTTTCA/GTGTAA 1 -- us2k12Minor allele frequency- G:0.05CSA WA 120
    rs14187191,2
    		C,F,A,H,--164012480(+) CATAGG/CAGAGG 1 -- us2k1 trp321Minor allele frequency- C:0.07NS EA NA WA CSA 2108
    rs168348521,2
    		C,F,H,--164012779(+) GTTCTG/AGTAAT 1 -- us2k1 tfbs317Minor allele frequency- A:0.09NA NS EA WA CSA 1582
    rs730622861,2
    		C,F,--164012963(+) CTGGTA/GAATCC 1 -- us2k14Minor allele frequency- G:0.15WA CSA 124
    rs46578361,2
    		C,F,H,--164012986(+) AATGAC/ATCATG 1 -- us2k1 tfbs35Minor allele frequency- A:0.02NS EA WA 504
    rs168348591,2
    		C,--164013849(+) CCGCCG/TGCGGG 1 -- us2k14Minor allele frequency- T:0.05MN EA CSA 359
    rs765861441,2
    		C,F,--164014603(+) AGTGTC/TGTAGG 1 -- int11Minor allele frequency- T:0.11WA 118
    rs730622871,2
    		C,F,--164014805(+) GCCAGA/CAATAG 1 -- int14Minor allele frequency- C:0.11WA CSA 125
    rs762948341,2
    		F,--164014895(+) AAACTA/GGTAGA 1 -- int11Minor allele frequency- G:0.05WA 118

    HapMap Linkage Disequilibrium report for RGS2 (192778169 - 192781407 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RGS2: --
    Human Gene Mutation Database (HGMD): RGS2

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    Disorders / Diseases
    for RGS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGS2 for disorders           About GeneDecksing

    OMIM gene information: 600861    OMIM disorders: --

    20/36 diseases for RGS2 (see all 36):    About MalaCards
    high blood pressure    generalized anxiety disorder    anxiety disorder    muscle hypertrophy
    anorexia nervosa    gitelman syndrome    panic disorder    acute lymphoblastic leukemia
    lymphoblastic leukemia    essential hypertension    syncope    squamous cell carcinoma
    multiple sclerosis    huntington's disease    hypertension    hyperlipidemia
    astrocytoma    aldosteronism    acute leukemia    pertussis

    2 diseases from the University of Copenhagen DISEASES database for RGS2:
    Hypertension     Panic disorder

    3 Novoseek disease relationships for RGS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertrophy 13.1 12 20362664 (4), 16380388 (3), 18207159 (2)
    astrocytoma 12.9 3 11488592 (2), 11755214 (1)
    shock 0 5 11488592 (2), 11322774 (2), 16733081 (1)

    Genetic Association Database (GAD): RGS2
    Human Genome Epidemiology (HuGE) Navigator: RGS2 (40 documents)

    Export disorders for RGS2 gene to outside databases

    Publications
    for RGS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS2 gene, integrated from 9 sources (see all 168):
    (articles sorted by number of sources associating them with RGS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells. (PubMed id 8179820)1, 2, 3 Siderovski D.P.... Forsdyke D.R. (1994)
    2. Mechanisms governing subcellular localization and function of human RGS2. (PubMed id 11278586)1, 2, 9 Heximer S.P....Blumer K.J. (2001)
    3. Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins. (PubMed id 17901199)1, 2, 9 Gu S....Heximer S.P. (2008)
    4. Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population. (PubMed id 16003176)1, 4, 9 Yang J....Miyata T. (2005)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. A functional polymorphism in RGS6 modulates the risk of bladder cancer. (PubMed id 15375002)1, 4 Berman D.M....Wu X. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. (PubMed id 14608379)1, 2 Tang K.M....Wang G. (2003)
    9. Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. (PubMed id 11063746)1, 2 Cunningham M.L.... Harden T.K. (2001)
    10. Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31. (PubMed id 7643615)1, 2 Wu H.-K.... Siderovski D.P. (1995)

    External Searches for RGS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RGS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5997 HGNC: 9998 AceView: RGS2 Ensembl:ENSG00000116741 euGenes: HUgn5997
    ECgene: RGS2 H-InvDB: RGS2

    Other Databases showing RGS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RGS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RGS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RGS2 gene:
    Search GeneIP for patents involving RGS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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