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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGS19 Gene

protein-coding GIFtS: 57
GCID: GC20M062704

regulator of G-protein signaling 19

(Previous name: regulator of G-protein signalling 19 )

Explore 7 diseases affiliated with
RGS19 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 19¹ ²		G Alpha Interacting Protein²
GAIP¹ ² ³		G Protein Signalling Regulator 19²
RGSGAIP¹ ²		Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 3 Interacting Protein²
Regulator Of G-Protein Signalling 19¹ ²		GNAI3IP³
G-Alpha-Interacting Protein² ³

External Ids:	HGNC: 13735¹	Entrez Gene: 10287²	Ensembl: ENSG00000171700⁷	OMIM: 605071⁵	UniProtKB: P49795³

Export aliases for RGS19 gene to outside databases

Previous GC identifers: GC20M062582 GC20M063383 GC20M063430 GC20M062174 GC20M059438

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS19:

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of

G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine

triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively

spliced transcript variants encoding the same protein isoform have been found for this gene. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: RGS19_HUMAN, P49795

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a

>> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein

Gene Wiki entry for RGS19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011333.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGS19 gene promoter:
STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS19 promoter sequence

Search SABiosciences Chromatin IP Primers for RGS19

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS19

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33

RGS19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS19 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M062704: view genomic region (about GC identifiers)

Start:	62,704,534 bp from pter	End:	62,711,324 bp from pter
Size:	6,791 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGS19_HUMAN, P49795 (See protein sequence)

Recommended Name: Regulator of G-protein signaling 19

Size: 217 amino acids; 24636 Da

Subunit: Interacts with GIPC PDZ domain

Subcellular location: Membrane; Lipid-anchor

1 PDB 3D structure from and Proteopedia for RGS19:

1CMZ (3D)

Secondary accessions: A8K216 E1P5G9 Q53XN0 Q8TD60

Explore the universe of human proteins at neXtProt for RGS19: NX_P49795

Post-translational modifications:

Fatty acylated. Heavily palmitoylated in the cysteine string motif¹

Phosphorylated, mainly on serine residues¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49795

RGS19 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005864.1 NP_001034556.1

ENSEMBL proteins:

ENSP00000333194 ENSP00000378483

Human Recombinant Protein Products for RGS19:

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	ProSpec Recombinant Protein for RGS19
	Uscn Proteins for RGS19

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	IBA	--
GO:0005794	Golgi apparatus	TAS	9571244
GO:0005834	colocalizes with heterotrimeric G-protein complex	TAS	8524874
GO:0005886	plasma membrane	IBA	--

RGS19 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGS19 for domains About GeneDecksing

3 InterPro domains/families:

IPR024066 Regulat_G_prot_signal_dom1

IPR000342 Regulat_G_prot_signal

IPR016137 Regulat_G_prot_signal_superfam

Graphical View of Domain Structure for InterPro Entry P49795

ProtoNet protein and cluster: P49795

1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

UniProtKB/Swiss-Prot: RGS19_HUMAN, P49795

Similarity: Contains 1 RGS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RGS19_HUMAN, P49795

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a

>> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001965	G-protein alpha-subunit binding	IEA	--
GO:0005096	GTPase activator activity	IBA	--
GO:0005515	protein binding	IPI	8524874

RGS19 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for RGS19:

Decreased Salmonella enterica

Decreased homologous recombina

Decreased nuclei size in G2M

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RGS19

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS19:
		hsa-miR-577 hsa-miR-3163 hsa-miR-141* hsa-miR-641 hsa-miR-129-5p hsa-miR-3617
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS19

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-AlphaQ Signaling

G-AlphaQ Signaling

1.00

G-AlphaI Signaling

0.47

Calcium Regulation in the Cardiac Cell

Calcium Regulation in the Cardiac Cell

1.00

Myometrial Relaxation and Contraction Pathways

0.43

Neurotrophic factor-mediated Trk receptor signaling

Neurotrophic factor-mediated Trk receptor signaling

1.00

Activation of cAMP-Dependent PKA

cAMP Pathway

0.77

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS19

	cAMP Pathway
	G-AlphaI Signaling
	G-AlphaQ Signaling

3 BioSystems Pathways for RGS19

	Myometrial Relaxation and Contraction Pathways
	Calcium Regulation in the Cardiac Cell
	Neurotrophic factor-mediated Trk receptor signaling

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RGS19

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/238 Interacting proteins for RGS19 (P49795^{1, 2, 3} ENSP00000333194⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 238)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659²^,³	MINT-8261879 I2D: score=2
GNAZ	P19086³, ENSP00000248996⁴	I2D: score=3 STRING: ENSP00000248996
CSNK2A2	P19784³, ENSP00000262506⁴	I2D: score=2 STRING: ENSP00000262506
GNAO1	P09471³, ENSP00000262493⁴	I2D: score=2 STRING: ENSP00000262493
MAPK1	P28482³, ENSP00000215832⁴	I2D: score=2 STRING: ENSP00000215832

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006914	autophagy	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8524874
GO:0007264	small GTPase mediated signal transduction	TAS	9571244
GO:0038032	termination of G-protein coupled receptor signaling pathway	IEA	--
GO:0043547	positive regulation of GTPase activity	IBA	--

RGS19 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RGS19 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGS19
5 Novoseek chemical compound relationships for RGS19 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	68.3	7	10364213 (2), 9305927 (1), 8756726 (1), 11520900 (1) (see all 6)
gdp	63.3	3	9305927 (1), 8774882 (1), 15488168 (1)
cysteine	16.9	3	9748280 (1), 17126529 (1)
tyrosine	2.51	1	11251075 (1)
calcium	0	1	12270936 (1)

Search CenterWatch for drugs/clinical trials and news about RGS19

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGS19 gene (2 alternative transcripts):

NM_005873.2 NM_001039467.1

Unigene Cluster for RGS19:

Regulator of G-protein signaling 19

Hs.422336 [show with all ESTs]

Unigene Representative Sequence: AK298240

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000332298(uc002yib.3) ENST00000493165 ENST00000479996 ENST00000395042(uc002yhy.3 uc002yhz.3)

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Additional cDNA sequence:

AF285096.1 AF285097.1 AF493939.1 AK290081.1 AK298240.1 AY585188.1 BC001318.1 BC054337.1

BC063010.1 BT009804.1 CR457430.1 X91809.1

9 DOTS entries:

DT.100698779 DT.111144 DT.95276707 DT.100775257 DT.97845097 DT.100782133 DT.100661131 DT.100697108

DT.100708043

24/159 AceView cDNA sequences (see all 159):

CR606250 CD368642 AA731423 BX114860 BE046387 CR592870 BM678883 BQ216436

AA648727 BM720314 BE895680 AW575348 AA954735 CR595472 AI828907 CB045254

AI678735 AA905091 AI589605 CK826332 BT009804 CR613987 AA938891 CR591868

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGS19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTTACTAG

About this image

RGS19 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RGS19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGS19

SOURCE GeneReport for Unigene cluster: Hs.422336

UniProtKB/Swiss-Prot: RGS19_HUMAN, P49795

Tissue specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP

SABiosciences Expression via Pathway-Focused PCR Array including RGS19:

Autophagy in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS19

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RGS19 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RGS19¹	regulator of G-protein signalling 19	78.52(n) 75.77(a)		374070 NM_204229.1 NP_989560.1
lizard (Anolis carolinensis)	Reptilia	RGS19⁶	--	69(a)	1 ↔ 1	4(155336012-155345879)
African clawed frog (Xenopus laevis)	Amphibia	rgs19-prov²	calcium/calmodulin-dependent protein kinase I	77.42(n)		BC056085.1
zebrafish (Danio rerio)	Actinopterygii	rgs19¹	regulator of G-protein signaling 19	71.48(n) 65.46(a)		100170801 NM_001130639.1 NP_001124111.1
fruit fly (Drosophila melanogaster)	Insecta	EG:52C10.2³	regulation of G-protein coupled receptor protein more	71(a)		54E9 --
worm (Caenorhabditis elegans)	Secernentea	rgs-2⁶ rgs-1⁶ (see all 3)	Regulator of G-protein signaling rgs-1 (see all 3)	46(a) 32(a) (see all 3)	many ↔ many many ↔ many (see all 3)	X(12712580-12728319) III(10014503-10016444)

ENSEMBL Gene Tree for RGS19 (if available)
TreeFam Gene Tree for RGS19 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RGS19 gene

RGS2² RGS8² RGS21² RGS3² RGS16² RGS20² RGS5² RGS17²

RGS1² RGS18² RGS4² RGS13²

18/19 SIMAP similar genes for RGS19 using alignment to 2 protein entries: RGS19_HUMAN (see all proteins) (see all similar genes):

GAIP RGS20 RGS17 RGS1 RGS4 RGS6

RGS7 RGS2 RGS8 RGS10 RGS18 RGS21

RGS5 RGS16 RGS11 RGS3 RGS9 RGS13

RGS19 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188860108^1,2		--	62704268(+)	`TGGCCC/TGACTT`	2	--	ds500¹		0	--	--	--	--
rs192580948^1,2		--	62704301(+)	`AGGGCA/GTGGAG`	2	--	ds500¹		0	--	--	--	--
rs76092180^1,2	C,F	--	62704332(+)	`AAGCAC/TAGCCA`	2	--	ds500¹		2		WA NA	238
rs184260408^1,2		--	62704496(+)	`TTCTCC/TAGTCT`	2	--	ds500¹		0	--	--	--	--
rs140273478^1,2		--	62704579(+)	`TTGGGA/GGGTTA`	2	--	ut3¹		0	--	--	--	--
rs144099006^1,2		--	62704586(+)	`GTTAGA/GGATAG`	2	--	ut3¹		0	--	--	--	--
rs10039^1,2	C,H	--	62704654(-)	`ATGAAC/TTTTAA`	2	--	ut3¹		4		MN NS NA	288
rs75215933^1,2	C,F	--	62704844(+)	`CCCATT/CGGCTG`	2	--	ut3¹		4		CSA WA	125
rs6011280^1,2	C,F,A,H	--	62705140(+)	`CGACAA/CCAACA`	2	--	ut3¹		22		NS EA NA CSA WA	2340
rs200289255^1,2		--	62705214(+)	`GGCCTC/TGGAGG`	4	K E	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RGS19 (62704534 - 62711324 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RGS19
1 CNV: 4108

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RGS19 for disorders           About GeneDecksing

OMIM gene information: 605071    OMIM disorders: --

7 diseases for RGS19:    About MalaCards

anorexia nervosa colon cancer hypertension pharyngitis

adenocarcinoma pancreatitis neuronitis

1 Novoseek disease relationship for RGS19 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer	33.9	3	12609989 (1), 9882627 (1), 15488168 (1)

Human Genome Epidemiology (HuGE) Navigator: RGS19 (2 documents)

Export disorders for RGS19 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RGS19 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with RGS19)

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GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. (PubMed id 8524874)^{1, 2, 3, 9} de Vries L.... Farquhar M.G. (1995)
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. (PubMed id 10993892)^{1, 2, 9} Ogier-Denis E.... Codogno P. (2000)
Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling. (PubMed id 10452897)^{1, 2, 9} de Alba E.... Tjandra N. (1999)
RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily. (PubMed id 9748280)^{1, 2, 9} Wang J.... Ross E.M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. (PubMed id 8986788)^{1, 2} de Vries L.... Farquhar M.G. (1996)
Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP. (PubMed id 10364213)^{1, 9} Woulfe D.S. and Stadel J.M. (1999)
Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells. (PubMed id 9305927)^{1, 9} Ogier-Denis E....Codogno P. (1997)
GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling. (PubMed id 15356268)^{1, 9} Jeanneteau F....Sokoloff P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10287	HGNC: 13735	AceView: RGS19	Ensembl:ENSG00000171700	euGenes: HUgn10287
ECgene: RGS19	H-InvDB: RGS19

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RGS19	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RGS19 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RGS19 gene:
Search GeneIP for patents involving RGS19

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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RGS19 Gene

regulator of G-protein signaling 19

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RGS19 Gene

regulator of G-protein signaling 19

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