Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS19 Gene

Aliases for RGS19 Gene

  • Regulator Of G Protein Signaling 19 2 3 5
  • Regulator Of G-Protein Signalling 19 2 3
  • Regulator Of G-Protein Signaling 19 2 3
  • GAIP 3 4
  • Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 3 Interacting Protein 3
  • G Protein Signalling Regulator 19 3
  • G Alpha Interacting Protein 3
  • G-Alpha-Interacting Protein 4
  • RGSGAIP 3
  • GNAI3IP 4

External Ids for RGS19 Gene

Previous GeneCards Identifiers for RGS19 Gene

  • GC20M062582
  • GC20M063383
  • GC20M063430
  • GC20M062174
  • GC20M062704
  • GC20M059438

Summaries for RGS19 Gene

Entrez Gene Summary for RGS19 Gene

  • G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS19 Gene

RGS19 (Regulator Of G Protein Signaling 19) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding. An important paralog of this gene is RGS20.

UniProtKB/Swiss-Prot for RGS19 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Gene Wiki entry for RGS19 Gene

Additional gene information for RGS19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS19 Gene

Genomics for RGS19 Gene

GeneHancer (GH) Regulatory Elements for RGS19 Gene

Promoters and enhancers for RGS19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I064076 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 592.7 +1.4 1439 4.9 SMAD1 SIN3A DMAP1 ZNF766 ZNF213 ZNF207 ZNF143 KLF13 SP3 SMARCB1 RGS19 OPRL1 MIR6813 C20orf204 PRPF6 GMEB2 LIME1 PCMTD2 ZGPAT
GH20I064062 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 40.6 +15.2 15157 5.3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 TCEA2 RGS19 MIR647 UCKL1 C20orf204 ENSG00000237371 MIR6813
GH20I064052 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.3 +24.4 24367 5.7 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B IRF4 SLC30A9 TCEA2 ENSG00000237371 SOX18 RGS19 PRPF6 OPRL1 SAMD10 ZNF512B C20orf204 UCKL1
GH20I063893 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +183.3 183312 5.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 DNAJC5 DIDO1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46
GH20I064120 Enhancer 1.1 Ensembl ENCODE 19.9 -40.4 -40416 0.8 ELF3 RB1 ARID4B NFXL1 ZNF2 ZNF48 RAD21 RFX5 SLC30A9 ARID2 RGS19 SOX18 NPBWR2 LOC105372727
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGS19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS19 gene promoter:

Genomic Locations for RGS19 Gene

Genomic Locations for RGS19 Gene
chr20:64,073,181-64,080,003
(GRCh38/hg38)
Size:
6,823 bases
Orientation:
Minus strand
chr20:62,704,534-62,711,324
(GRCh37/hg19)

Genomic View for RGS19 Gene

Genes around RGS19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS19 Gene

Proteins for RGS19 Gene

  • Protein details for RGS19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49795-RGS19_HUMAN
    Recommended name:
    Regulator of G-protein signaling 19
    Protein Accession:
    P49795
    Secondary Accessions:
    • A8K216
    • E1P5G9
    • Q53XN0
    • Q8TD60

    Protein attributes for RGS19 Gene

    Size:
    217 amino acids
    Molecular mass:
    24636 Da
    Quaternary structure:
    • Interacts with GIPC PDZ domain.

    Three dimensional structures from OCA and Proteopedia for RGS19 Gene

neXtProt entry for RGS19 Gene

Post-translational modifications for RGS19 Gene

Other Protein References for RGS19 Gene

No data available for DME Specific Peptides for RGS19 Gene

Domains & Families for RGS19 Gene

Gene Families for RGS19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS19 Gene

Suggested Antigen Peptide Sequences for RGS19 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS19: view

No data available for UniProtKB/Swiss-Prot for RGS19 Gene

Function for RGS19 Gene

Molecular function for RGS19 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Phenotypes From GWAS Catalog for RGS19 Gene

Gene Ontology (GO) - Molecular Function for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 8524874
genes like me logo Genes that share ontologies with RGS19: view
genes like me logo Genes that share phenotypes with RGS19: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS19 Gene

Localization for RGS19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS19 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS19 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
plasma membrane 2
extracellular 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus TAS 9571244
GO:0005834 colocalizes_with heterotrimeric G-protein complex TAS 8524874
GO:0005903 brush border IEA --
GO:0016020 membrane TAS 9571244
genes like me logo Genes that share ontologies with RGS19: view

Pathways & Interactions for RGS19 Gene

genes like me logo Genes that share pathways with RGS19: view

SIGNOR curated interactions for RGS19 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8524874
GO:0007264 small GTPase mediated signal transduction TAS 9571244
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS19: view

Drugs & Compounds for RGS19 Gene

(3) Drugs for RGS19 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RGS19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS19: view

Transcripts for RGS19 Gene

Unigene Clusters for RGS19 Gene

Regulator of G-protein signaling 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS19 Gene

No ASD Table

Relevant External Links for RGS19 Gene

GeneLoc Exon Structure for
RGS19
ECgene alternative splicing isoforms for
RGS19

Expression for RGS19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS19 Gene

mRNA differential expression in normal tissues according to GTEx for RGS19 Gene

This gene is overexpressed in Whole Blood (x24.5) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for RGS19 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.8) and Monocytes (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RGS19 Gene



Protein tissue co-expression partners for RGS19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RGS19 Gene:

RGS19

SOURCE GeneReport for Unigene cluster for RGS19 Gene:

Hs.422336

mRNA Expression by UniProt/SwissProt for RGS19 Gene:

P49795-RGS19_HUMAN
Tissue specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Evidence on tissue expression from TISSUES for RGS19 Gene

  • Nervous system(4.5)
  • Blood(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with RGS19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS19 Gene

Orthologs for RGS19 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS19 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia RGS19 33 34
  • 90.32 (n)
cow
(Bos Taurus)
Mammalia RGS19 33 34
  • 88.33 (n)
rat
(Rattus norvegicus)
Mammalia Rgs19 33
  • 84.42 (n)
mouse
(Mus musculus)
Mammalia Rgs19 33 16 34
  • 84.27 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS19 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS19 33 34
  • 79.68 (n)
lizard
(Anolis carolinensis)
Reptilia RGS19 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs19 33
  • 68.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia rgs19-prov 33
zebrafish
(Danio rerio)
Actinopterygii rgs19 33 34
  • 72.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta EG:52C10.2 35
  • 71 (a)
CG5036 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-2 34
  • 48 (a)
ManyToMany
rgs-1 34
  • 35 (a)
ManyToMany
Species where no ortholog for RGS19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS19 Gene

ENSEMBL:
Gene Tree for RGS19 (if available)
TreeFam:
Gene Tree for RGS19 (if available)

Paralogs for RGS19 Gene

Paralogs for RGS19 Gene

(19) SIMAP similar genes for RGS19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS19: view

Variants for RGS19 Gene

Sequence variations from dbSNP and Humsavar for RGS19 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000465031 -- 64,076,446(-) C/T intron_variant
rs1001361529 -- 64,076,846(-) A/C intron_variant
rs1002015938 -- 64,080,082(-) A/C/T upstream_transcript_variant
rs1002416386 -- 64,076,537(-) C/T coding_sequence_variant, missense_variant
rs1002638504 -- 64,081,035(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS19 Gene

Variant ID Type Subtype PubMed ID
dgv4345n100 CNV gain 25217958
dgv7701n54 CNV loss 21841781
esv1008416 CNV insertion 20482838
esv2758807 CNV gain+loss 17122850
nsv1078795 CNV insertion 25765185
nsv1117295 CNV tandem duplication 24896259
nsv1125222 CNV insertion 24896259
nsv1129218 CNV insertion 24896259
nsv1149957 CNV insertion 26484159
nsv179409 CNV insertion 16902084
nsv428381 CNV gain+loss 18775914
nsv470564 CNV gain 18288195
nsv509785 CNV insertion 20534489
nsv586703 CNV loss 21841781
nsv586732 CNV loss 21841781
nsv953310 CNV deletion 24416366

Variation tolerance for RGS19 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS19 Gene

Disorders for RGS19 Gene

Additional Disease Information for RGS19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGS19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS19 Gene

Publications for RGS19 Gene

  1. GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. (PMID: 8524874) De Vries L … Farquhar MG (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
  2. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. (PMID: 10993892) Ogier-Denis E … Codogno P (The Journal of biological chemistry 2000) 3 4 22 58
  3. Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling. (PMID: 10452897) de Alba E … Tjandra N (Journal of molecular biology 1999) 3 4 22 58
  4. RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily. (PMID: 9748280) Wang J … Ross EM (The Journal of biological chemistry 1998) 3 4 22 58
  5. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58

Products for RGS19 Gene

Sources for RGS19 Gene

Content
Loading form....