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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS19 Gene

protein-coding   GIFtS: 58
GCID: GC20M062704

Regulator Of G-Protein Signaling 19

(Previous name: regulator of G-protein signalling 19)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 191 2     G Alpha Interacting Protein2
Regulator Of G-Protein Signalling 191 2     G Protein Signalling Regulator 192
GAIP2 3     Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 3
Interacting Protein2
G-Alpha-Interacting Protein2 3     GNAI3IP3
RGSGAIP2     

External Ids:    HGNC: 137351   Entrez Gene: 102872   Ensembl: ENSG000001717007   OMIM: 6050715   UniProtKB: P497953   

Export aliases for RGS19 gene to outside databases

Previous GC identifers: GC20M062582 GC20M063383 GC20M063430 GC20M062174 GC20M059438


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS19 Gene:
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators
of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine
triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.
Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RGS19 Gene: 
RGS19 (regulator of G-protein signaling 19) is a protein-coding gene. Diseases associated with RGS19 include anorexia nervosa, and colon cancer, and among its related super-pathways are G-AlphaQ Signaling and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include G-protein alpha-subunit binding and GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS19_HUMAN, P49795
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 >
G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the
G-protein

Gene Wiki entry for RGS19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011333.6  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS19 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS19 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

RGS19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS19 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062704:  view genomic region     (about GC identifiers)

Start:
62,704,534 bp from pter      End:
62,711,324 bp from pter
Size:
6,791 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGS19_HUMAN, P49795 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 19  
Size: 217 amino acids; 24636 Da
Subunit: Interacts with GIPC PDZ domain
Subcellular location: Membrane; Lipid-anchor
1 PDB 3D structure from and Proteopedia for RGS19:
1CMZ (3D)    
Secondary accessions: A8K216 E1P5G9 Q53XN0 Q8TD60

Explore the universe of human proteins at neXtProt for RGS19: NX_P49795

Explore proteomics data for RGS19 at MOPED 

Post-translational modifications:

  • UniProtKB: Fatty acylated. Heavily palmitoylated in the cysteine string motif
  • UniProtKB: Phosphorylated, mainly on serine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49795

  • RGS19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGS19 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005864.1  NP_001034556.1  

    ENSEMBL proteins: 
     ENSP00000333194   ENSP00000378483  

    Human Recombinant Protein Products for RGS19: 
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    Cloud-Clone Corp. Proteins for RGS19 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005794Golgi apparatus TAS9571244
    GO:0005834colocalizes with heterotrimeric G-protein complex TAS8524874
    GO:0005886plasma membrane IBA--
    GO:0005903brush border IEA--

    RGS19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry P49795

    ProtoNet protein and cluster: P49795

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS19_HUMAN, P49795
    Similarity: Contains 1 RGS domain


    RGS19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS19_HUMAN, P49795
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 >
    G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the
    G-protein

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI8524874
         
    RGS19 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RGS19:
     Decreased Salmonella enterica   Decreased homologous recombina  Decreased nuclei size in G2M 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRGS19 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGS19 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    3Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    4Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS19
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    3 BioSystems Pathways for RGS19
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    Neurotrophic factor-mediated Trk receptor signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/238 Interacting proteins for RGS19 (P497951, 2, 3 ENSP000003331944) via UniProtKB, MINT, STRING, and/or I2D (see all 238)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261879 I2D: score=2 
    GNAZP190863, ENSP000002489964I2D: score=3 STRING: ENSP00000248996
    CSNK2A2P197843, ENSP000002625064I2D: score=2 STRING: ENSP00000262506
    GNAO1P094713, ENSP000002624934I2D: score=2 STRING: ENSP00000262493
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS8524874
    GO:0007264small GTPase mediated signal transduction TAS9571244
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity IBA--

    RGS19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS19 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS19

    5 Novoseek inferred chemical compound relationships for RGS19 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 68.3 7 10364213 (2), 9305927 (1), 8756726 (1), 11520900 (1) (see all 6)
    gdp 63.3 3 9305927 (1), 8774882 (1), 15488168 (1)
    cysteine 16.9 3 9748280 (1), 17126529 (1)
    tyrosine 2.51 1 11251075 (1)
    calcium 0 1 12270936 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGS19 gene (2 alternative transcripts): 
    NM_005873.2  NM_001039467.1  

    Unigene Cluster for RGS19:

    Regulator of G-protein signaling 19
    Hs.422336  [show with all ESTs]
    Unigene Representative Sequence: AK298240
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332298(uc002yib.3) ENST00000493165 ENST00000479996 ENST00000395042(uc002yhy.3 uc002yhz.3)

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    hsa-miR-577 hsa-miR-3163 hsa-miR-141* hsa-miR-641 hsa-miR-129-5p hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmidRGS19 3' UTR sequence
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    Additional mRNA sequence: 

    AF285096.1 AF285097.1 AF493939.1 AK290081.1 AK298240.1 AY585188.1 BC001318.1 BC054337.1 
    BC063010.1 BT009804.1 CR457430.1 X91809.1 

    9 DOTS entries:

    DT.100698779  DT.111144  DT.95276707  DT.100775257  DT.97845097  DT.100782133  DT.100661131  DT.100697108 
    DT.100708043 

    24/159 AceView cDNA sequences (see all 159):

    BP338087 CR591957 BQ232098 CB045254 CR595472 CR606250 CR592870 BE046387 
    AI383854 BI711070 AI589605 BC054337 BM423387 CR591868 AI828907 CD368642 
    BM720314 AW575348 BT009804 BM922201 AA954735 BC001318 AA905091 BM678883 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS19 expression in normal human tissues (normalized intensities)      RGS19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTACTAG
    RGS19 Expression
    About this image


    RGS19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See RGS19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS19

    SOURCE GeneReport for Unigene cluster: Hs.422336

    UniProtKB/Swiss-Prot: RGS19_HUMAN, P49795
    Tissue specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP

        SABiosciences Expression via Pathway-Focused PCR Array including RGS19: 
              Autophagy in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGS19 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs191 , 5 regulator of G-protein signaling 191, 5 84.27(n)1
    91.59(a)1
      2 (103.72 cM)5
    564701  NM_026446.31  NP_080722.11 
     1816884195 
    chicken
    (Gallus gallus)
    Aves RGS191 regulator of G-protein signalling 19 78.52(n)
    75.77(a)
      374070  NM_204229.1  NP_989560.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS196
    Uncharacterized protein
    68(a)
    1 ↔ 1
    4(155269153-155345879)
    African clawed frog
    (Xenopus laevis)
    Amphibia rgs19-prov2 calcium/calmodulin-dependent protein kinase I 77.42(n)    BC056085.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgs191 regulator of G-protein signaling 19 71.48(n)
    65.46(a)
      100170801  NM_001130639.1  NP_001124111.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:52C10.23 regulation of G-protein coupled
    receptor protein more
    71(a)   54E9   --
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-26
    rgs-16
    Regulator of G-protein signaling rgs-1
    46(a)
    34(a)
    many ↔ many
    many ↔ many
    X(12712651-12728389)
    III(10014593-10016534)


    ENSEMBL Gene Tree for RGS19 (if available)
    TreeFam Gene Tree for RGS19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS19 gene
    RGS22  RGS82  RGS212  RGS32  RGS202  RGS162  RGS172  RGS52  
    RGS12  RGS182  RGS132  RGS42  
    18/19 SIMAP similar genes for RGS19 using alignment to 2 protein entries:     RGS19_HUMAN (see all proteins) (see all similar genes):
    GAIP    RGS20    RGS17    RGS1    RGS4    RGS6
    RGS7    RGS2    RGS8    RGS10    RGS18    RGS21
    RGS5    RGS16    RGS11    RGS3    RGS9    RGS13

    RGS19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/161 SNPs in RGS19 are shown (see all 161)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888601081,2
    --62704268(+) TGGCCC/TGACTT 2 -- ds50010--------
    rs1925809481,2
    --62704301(+) AGGGCA/GTGGAG 2 -- ds50010--------
    rs760921801,2
    C,F--62704332(+) AAGCAC/TAGCCA 2 -- ds50012Minor allele frequency- T:0.03WA NA 238
    rs1842604081,2
    --62704496(+) TTCTCC/TAGTCT 2 -- ds50010--------
    rs1402734781,2
    C--62704579(+) TTGGGA/GGGTTA 2 -- ut310--------
    rs1440990061,2
    --62704586(+) GTTAGA/GGATAG 2 -- ut310--------
    rs100391,2
    C,H--62704654(-) ATGAAC/TTTTAA 2 -- ut314Minor allele frequency- T:0.00MN NS NA 288
    rs752159331,2
    C,F--62704844(+) CCCATT/CGGCTG 2 -- ut314Minor allele frequency- C:0.16CSA WA 125
    rs60112801,2
    C,F,A,H--62705140(+) CGACAA/CCAACA 2 -- ut3122Minor allele frequency- C:0.36NS EA NA CSA WA 2340
    rs2002892551,2
    --62705214(+) GGCCTC/TGGAGG 4 K E mis10--------

    HapMap Linkage Disequilibrium report for RGS19 (62704534 - 62711324 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for RGS19 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv179409CNV Insertion16902084
    nsv509785CNV Insertion20534489
    esv1008416CNV Insertion20482838
    dgv4661n71CNV Loss21882294
    dgv4659n71CNV Loss21882294
    nsv913313CNV Loss21882294
    nsv913270CNV Loss21882294
    dgv4658n71CNV Loss21882294
    dgv4662n71CNV Loss21882294
    nsv913190CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605071    OMIM disorders: --

    6 diseases for RGS19:    About MalaCards
    anorexia nervosa    colon cancer    hypertension    endotheliitis
    adenocarcinoma    pancreatitis


    RGS19 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RGS19 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 33.9 3 12609989 (1), 9882627 (1), 15488168 (1)

    Genetic Association Database (GAD): RGS19
    Human Genome Epidemiology (HuGE) Navigator: RGS19 (2 documents)

    Export disorders for RGS19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS19 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with RGS19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. (PubMed id 8524874)1, 2, 3, 9 de Vries L.... Farquhar M.G. (1995)
    2. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. (PubMed id 10993892)1, 2, 9 Ogier-Denis E.... Codogno P. (2000)
    3. Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling. (PubMed id 10452897)1, 2, 9 de Alba E.... Tjandra N. (1999)
    4. RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz GTPase-activating protein subfamily. (PubMed id 9748280)1, 2, 9 Wang J.... Ross E.M. (1998)
    5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    6. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PubMed id 18360038)1, 4 Kohara K....Miki T. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    9. GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. (PubMed id 8986788)1, 2 de Vries L.... Farquhar M.G. (1996)
    10. Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP. (PubMed id 10364213)1, 9 Woulfe D.S. and Stadel J.M. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10287 HGNC: 13735 AceView: RGS19 Ensembl:ENSG00000171700 euGenes: HUgn10287
    ECgene: RGS19 H-InvDB: RGS19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGS19 gene:
    Search GeneIP for patents involving RGS19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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