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Aliases for RGS18 Gene

Aliases for RGS18 Gene

  • Regulator Of G-Protein Signaling 18 2 3 5
  • Regulator Of G-Protein Signalling 18 2 3
  • RGS13 3 4
  • Regulator Of G-Protein Signalling 13 3

External Ids for RGS18 Gene

Previous GeneCards Identifiers for RGS18 Gene

  • GC01P189917
  • GC01P187641
  • GC01P188594
  • GC01P189415
  • GC01P188859
  • GC01P190394
  • GC01P163363

Summaries for RGS18 Gene

Entrez Gene Summary for RGS18 Gene

  • This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS18 Gene

RGS18 (Regulator Of G-Protein Signaling 18) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and G-protein signaling G-Protein alpha-i signaling cascades. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS3.

UniProtKB/Swiss-Prot for RGS18 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

Gene Wiki entry for RGS18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS18 Gene

Genomics for RGS18 Gene

Regulatory Elements for RGS18 Gene

Enhancers for RGS18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGS18 on UCSC Golden Path with GeneCards custom track

Promoters for RGS18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGS18 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS18 Gene

192,158,457 bp from pter
192,187,172 bp from pter
28,716 bases
Plus strand

Genomic View for RGS18 Gene

Genes around RGS18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS18 Gene

Proteins for RGS18 Gene

  • Protein details for RGS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 18
    Protein Accession:
    Secondary Accessions:
    • B2RD23

    Protein attributes for RGS18 Gene

    235 amino acids
    Molecular mass:
    27582 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS18 Gene

neXtProt entry for RGS18 Gene

Proteomics data for RGS18 Gene at MOPED

Post-translational modifications for RGS18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS18 Gene

Domains & Families for RGS18 Gene

Gene Families for RGS18 Gene

Protein Domains for RGS18 Gene

Suggested Antigen Peptide Sequences for RGS18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RGS domain.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS18: view

Function for RGS18 Gene

Molecular function for RGS18 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
genes like me logo Genes that share phenotypes with RGS18: view

Animal Models for RGS18 Gene

MGI Knock Outs for RGS18:

Animal Model Products

miRNA for RGS18 Gene

miRTarBase miRNAs that target RGS18

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS18 Gene

Localization for RGS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS18 Gene


Subcellular locations from

Jensen Localization Image for RGS18 Gene COMPARTMENTS Subcellular localization image for RGS18 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RGS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA --
genes like me logo Genes that share ontologies with RGS18: view

Pathways & Interactions for RGS18 Gene

genes like me logo Genes that share pathways with RGS18: view

Gene Ontology (GO) - Biological Process for RGS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS18: view

No data available for SIGNOR curated interactions for RGS18 Gene

Drugs & Compounds for RGS18 Gene

No Compound Related Data Available

Transcripts for RGS18 Gene

Unigene Clusters for RGS18 Gene

Regulator of G-protein signaling 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS18 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for RGS18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS18 Gene

mRNA expression in normal human tissues for RGS18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS18 Gene

This gene is overexpressed in Whole Blood (x34.5) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for RGS18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.3) and Platelet (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS18 Gene

SOURCE GeneReport for Unigene cluster for RGS18 Gene Hs.440890

mRNA Expression by UniProt/SwissProt for RGS18 Gene

Tissue specificity: Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.
genes like me logo Genes that share expression patterns with RGS18: view

Protein tissue co-expression partners for RGS18 Gene

- Elite partner

Primer Products

Orthologs for RGS18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RGS18 35
  • 90.21 (n)
  • 85.96 (a)
RGS18 36
  • 86 (a)
(Canis familiaris)
Mammalia RGS18 35
  • 92.62 (n)
  • 91.49 (a)
RGS18 36
  • 91 (a)
(Mus musculus)
Mammalia Rgs18 35
  • 86.52 (n)
  • 83.83 (a)
Rgs18 16
Rgs18 36
  • 84 (a)
(Pan troglodytes)
Mammalia RGS18 35
  • 99.43 (n)
  • 99.15 (a)
RGS18 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rgs18 35
  • 86.52 (n)
  • 82.13 (a)
(Monodelphis domestica)
Mammalia RGS18 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia RGS18 36
  • 70 (a)
(Gallus gallus)
Aves RGS18 35
  • 69.38 (n)
  • 63.95 (a)
RGS18 36
  • 62 (a)
(Anolis carolinensis)
Reptilia RGS18 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs18 35
  • 61.62 (n)
  • 53.68 (a)
(Danio rerio)
Actinopterygii rgs18 35
  • 57.48 (n)
  • 52.04 (a)
rgs18 36
  • 48 (a)
Species with no ortholog for RGS18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS18 Gene

Gene Tree for RGS18 (if available)
Gene Tree for RGS18 (if available)

Paralogs for RGS18 Gene

Paralogs for RGS18 Gene

(18) SIMAP similar genes for RGS18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS18: view

Variants for RGS18 Gene

Sequence variations from dbSNP and Humsavar for RGS18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1317071 -- 192,169,104(-) TTAAA(A/G)TAACT intron-variant
rs1937235 -- 192,182,044(+) taata(A/C)ctcaa intron-variant
rs1937236 -- 192,165,317(+) atcga(C/T)gacaa intron-variant
rs2068805 -- 192,184,766(+) CCATT(C/T)ATAAT utr-variant-3-prime
rs2247482 -- 192,187,196(+) GTTAA(C/T)TGACT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RGS18 Gene

Variant ID Type Subtype PubMed ID
esv2663862 CNV Deletion 23128226

Variation tolerance for RGS18 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RGS18 Gene

Disorders for RGS18 Gene

Relevant External Links for RGS18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGS18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS18 Gene

Publications for RGS18 Gene

  1. Molecular cloning and characterization of a novel regulator of G- protein signaling from mouse hematopoietic stem cells. (PMID: 11042171) Park I.K. … Clarke M.F. (J. Biol. Chem. 2001) 2 3 4 67
  2. A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. (PMID: 22210881) Ma P. … Brass L.F. (Blood 2012) 3
  3. Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets. (PMID: 22234696) Gegenbauer K. … Smolenski A. (Blood 2012) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for RGS18 Gene

Sources for RGS18 Gene