Aliases for RGS18 Gene
External Ids for RGS18 Gene
Previous GeneCards Identifiers for RGS18 Gene
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS18 Gene
RGS18 (Regulator Of G Protein Signaling 18) is a Protein Coding gene. Diseases associated with RGS18 include Cardiomyopathy, Familial Hypertrophic. Among its related pathways are MAPK-Erk Pathway and RET signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS3.
UniProtKB/Swiss-Prot for RGS18 Gene
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.