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RGS18 Gene

protein-coding   GIFtS: 58
GCID: GC01P192127

Regulator Of G-Protein Signaling 18

(Previous name: regulator of G-protein signalling 18)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 181 2
Regulator Of G-Protein Signalling 181 2
RGS132 3
Regulator Of G-Protein Signalling 132

External Ids:    HGNC: 142611   Entrez Gene: 644072   Ensembl: ENSG000001506817   OMIM: 6071925   UniProtKB: Q9NS283   

Export aliases for RGS18 gene to outside databases

Previous GC identifers: GC01P189917 GC01P187641 GC01P188594 GC01P189415 GC01P188859 GC01P190394 GC01P163363


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS18 Gene:
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved,
120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by
binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the
rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit
heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional
splice variants of this gene have been observed but have not been thoroughly characterized. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RGS18 Gene:
RGS18 (regulator of G-protein signaling 18) is a protein-coding gene. Diseases associated with RGS18 include anorexia nervosa, and squamous cell carcinoma. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS18_HUMAN, Q9NS28
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha

Gene Wiki entry for RGS18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS18 gene promoter:
         STAT5B   Pbx1a   AML1a   E4BP4   HNF-3beta   FOXL1   C/EBPalpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS18 promoter sequence
   Search Chromatin IP Primers for RGS18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.2   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31.2

RGS18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P192127:  view genomic region     (about GC identifiers)

Start:
192,127,587 bp from pter      End:
192,154,945 bp from pter
Size:
27,359 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RGS18_HUMAN, Q9NS28 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 18  
Size: 235 amino acids; 27582 Da
3 PDB 3D structures from and Proteopedia for RGS18:
2DLV (3D)        2JM5 (3D)        2OWI (3D)    
Secondary accessions: B2RD23

Explore the universe of human proteins at neXtProt for RGS18: NX_Q9NS28

Explore proteomics data for RGS18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_570138.1  
    ENSEMBL proteins: 
     ENSP00000356430  
    Reactome Protein details: Q9NS28

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry Q9NS28

    ProtoNet protein and cluster: Q9NS28

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS18_HUMAN, Q9NS28
    Similarity: Contains 1 RGS domain


    RGS18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS18_HUMAN, Q9NS28
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
         
    RGS18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RGS18:
     Decreased viability 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rgs18):
     no phenotypic analysis 

    RGS18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS18
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGS18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGS18

    miRNA
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    miRTarBase miRNAs that target RGS18:
    hsa-mir-335-5p (MIRT017654)

    Block miRNA regulation of human, mouse, rat RGS18 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RGS18:
    hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidRGS18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RGS18

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    Sino Biological Human cDNA Clone for RGS18
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGS18_HUMAN, Q9NS28: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--

    RGS18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS18 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    4Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    5Activation of cAMP-Dependent PKA
    cAMP Pathway0.77

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS18
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    1 GeneGo (Thomson Reuters) Pathway for RGS18
        G-protein signaling G-Protein alpha-i signaling cascades

    2 BioSystems Pathways for RGS18
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell


    2 Reactome Pathways for RGS18
        G alpha (q) signalling events
    G alpha (i) signalling events



    RGS18 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS18
    Interactions:

        GeneGlobe Interaction Network for RGS18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RGS18 (Q9NS283 ENSP000003564304) via UniProtKB, MINT, STRING, and/or I2D (see all 223)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    GNAI3P087543, ENSP000003588674I2D: score=2 STRING: ENSP00000358867
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    GNAI2P048993, ENSP000003129994I2D: score=2 STRING: ENSP00000312999
    C3AR1ENSP000003020794STRING: ENSP00000302079
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway ----
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity ----

    RGS18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS18



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RGS18 gene: 
    NM_130782.2  

    Unigene Cluster for RGS18:

    Regulator of G-protein signaling 18
    Hs.440890  [show with all ESTs]
    Unigene Representative Sequence: BC020632
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367460(uc001gsg.3) ENST00000481707 ENST00000492967 ENST00000491030

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RGS18:
    hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidRGS18 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RGS18 (NM_130782)
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    Primer
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    OriGene qPCR primer pairs and template standards for RGS18
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RGS18
      QuantiTect SYBR Green Assays in human, mouse, rat RGS18
      QuantiFast Probe-based Assays in human, mouse, rat RGS18

    Additional mRNA sequence: 

    AF076642.1 AF268036.1 AK057114.1 AK292015.1 AK315377.1 BC020632.1 

    2 DOTS entries:

    DT.107870  DT.121356564 

    Selected AceView cDNA sequences (see all 30):

    AA195206 N59342 BP343366 NM_130782 CR602825 BC020632 BX350311 AV716055 
    BI909559 AF076642 AL557903 BX644490 CD642093 AV714060 AK057114 AF268036 
    BG572311 BG564257 N98410 AL579846 AV714044 AV715708 AV712845 BM146419 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RGS18    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                          -           -                     
    SP2:                          -                                 
    SP3:                          -     -     -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for RGS18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS18 expression in normal human tissues (normalized intensities)      RGS18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTAGGCTT
    RGS18 Expression
    About this image


    RGS18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Dermis (Integumentary System)
    RGS18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440890

    UniProtKB/Swiss-Prot: RGS18_HUMAN, Q9NS28
    Tissue specificity: Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RGS18 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs181 , 5 regulator of G-protein signaling 181, 5 86.52(n)1
    83.83(a)1
      1 (62.99 cM)5
    642141  NM_022881.41  NP_075019.11 
     1447526835 
    chicken
    (Gallus gallus)
    Aves RGS181 regulator of G-protein signaling 18 69.38(n)
    63.95(a)
      424361  NM_001257327.1  NP_001244256.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS186
    regulator of G-protein signaling 18
    62(a)
    1 ↔ 1
    GL343267.1(1732242-1740223)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rgs181 regulator of G-protein signaling 18 61.62(n)
    53.68(a)
      493454  NM_001008091.1  NP_001008092.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgs181 regulator of G-protein signaling 18 57.48(n)
    52.04(a)
      768164  NM_001077307.1  NP_001070775.1 


    ENSEMBL Gene Tree for RGS18 (if available)
    TreeFam Gene Tree for RGS18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS18 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS162  RGS172  
    RGS52  RGS12  RGS132  RGS42  
    18 SIMAP similar genes for RGS18 using alignment to 1 protein entry:     RGS18_HUMAN:
    RGS21    RGS17    RGS4    RGS1    RGS5    RGS13
    RGS8    RGS20    RGS6    RGS16    RGS3    RGS7
    RGS19    RGS2    RGS9    RGS10    RGS11    RGS14

    RGS18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS18 (see all 507)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899115801,2
    --192125665(+) GGCCAG/TGCTGG 1 -- us2k10--------
    rs1385649781,2
    --192125723(+) GCTGGG/TATTAC 1 -- us2k10--------
    rs1148557801,2
    C--192125749(+) TGCCCA/GGCAAC 1 -- us2k10--------
    rs1829525281,2
    --192125822(+) TCACAC/TATAAA 1 -- us2k10--------
    rs1882294381,2
    --192126157(+) CAGGGA/GGTATA 1 -- us2k10--------
    rs1932834961,2
    --192126161(+) GGGTAC/TATGTA 1 -- us2k10--------
    rs1855503421,2
    --192126191(+) CTTTAA/GTTTCA 1 -- us2k10--------
    rs1507532431,2
    C--192126381(+) AGCACA/GTAGTA 1 -- us2k10--------
    rs796316671,2
    C,F--192126396(+) ATCAAA/GGGCTC 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1880398761,2
    --192126397(+) TCAAAC/GGCTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGS18 (192127587 - 192154945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RGS18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663862CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607192    OMIM disorders: --

    3 diseases for RGS18:    About MalaCards
    anorexia nervosa    squamous cell carcinoma    hepatitis


    RGS18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS18
    Human Genome Epidemiology (HuGE) Navigator: RGS18 (5 documents)

    Export disorders for RGS18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS18 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with RGS18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel regulator of G- protein signaling from mouse hematopoietic stem cells. (PubMed id 11042171)1, 2, 3 Park I.K.... Clarke M.F. (J. Biol. Chem. 2001)
    2. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (Carcinogenesis 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Cloning and characterization of a novel regulator of G protein signalling in human platelets. (PubMed id 11955952)1, 2 Gagnon A.W.... Leadley R.J. Jr. (Cell. Signal. 2002)
    9. Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets. (PubMed id 22234696)1 Gegenbauer K....Smolenski A. (Blood 2012)
    10. A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. (PubMed id 22210881)1 Ma P....Brass L.F. (Blood 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64407 HGNC: 14261 AceView: RGS18 Ensembl:ENSG00000150681 euGenes: HUgn64407
    ECgene: RGS18 H-InvDB: RGS18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGS18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS18 gene:
    Search GeneIP for patents involving RGS18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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