Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS17 Gene

Aliases for RGS17 Gene

  • Regulator Of G-Protein Signaling 17 2 3
  • Regulator Of G-Protein Signalling 17 2
  • RGS-17 3
  • HRGS17 3
  • RGSZ2 3

External Ids for RGS17 Gene

Summaries for RGS17 Gene

Entrez Gene Summary for RGS17 Gene

  • This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS17 Gene

RGS17 (Regulator Of G-Protein Signaling 17) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS17 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Gene Wiki entry for RGS17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS17 Gene

Genomics for RGS17 Gene

Genomic Location for RGS17 Gene

Start:
153,004,459 bp from pter
End:
153,131,256 bp from pter
Size:
126,798 bases
Orientation:
Minus strand

Genomic View for RGS17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS17 Gene

Regulatory Elements for RGS17 Gene

Proteins for RGS17 Gene

  • Protein details for RGS17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGC6-RGS17_HUMAN
    Recommended name:
    Regulator of G-protein signaling 17
    Protein Accession:
    Q9UGC6
    Secondary Accessions:
    • Q5TF49
    • Q8TD61
    • Q9UJS8

    Protein attributes for RGS17 Gene

    Size:
    210 amino acids
    Molecular mass:
    24359 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS17 Gene

neXtProt entry for RGS17 Gene

Proteomics data for RGS17 Gene at MOPED

Post-translational modifications for RGS17 Gene

  • Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).
  • N- and O-glycosylated in synapsomal membranes.
  • Serine phosphorylated in synapsomal membranes.
  • Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS17 Gene

Domains for RGS17 Gene

Gene Families for RGS17 Gene

HGNC:
  • RGS :Regulators of G-protein signaling

Protein Domains for RGS17 Gene

UniProtKB/Swiss-Prot:

RGS17_HUMAN
Domain:
  • Contains 1 RGS domain.:
    • Q9UGC6
genes like me logo Genes that share domains with RGS17: view

Function for RGS17 Gene

Molecular function for RGS17 Gene

UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Gene Ontology (GO) - Molecular Function for RGS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RGS17: view

Phenotypes for RGS17 Gene

GenomeRNAi human phenotypes for RGS17:
genes like me logo Genes that share phenotypes with RGS17: view

miRNA for RGS17 Gene

miRTarBase miRNAs that target RGS17

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGS17 Gene

Localization for RGS17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS17 Gene

Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS17 Gene COMPARTMENTS Subcellular localization image for RGS17 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
extracellular 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RGS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS17: view

Pathways for RGS17 Gene

genes like me logo Genes that share pathways with RGS17: view

Pathways by source for RGS17 Gene

Gene Ontology (GO) - Biological Process for RGS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RGS17: view

Transcripts for RGS17 Gene

mRNA/cDNA for RGS17 Gene

Unigene Clusters for RGS17 Gene

Regulator of G-protein signaling 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS17 Gene

No ASD Table

Relevant External Links for RGS17 Gene

GeneLoc Exon Structure for
RGS17
ECgene alternative splicing isoforms for
RGS17

Expression for RGS17 Gene

mRNA expression in normal human tissues for RGS17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS17 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.9) and Brain - Cerebellum (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGS17 Gene

SOURCE GeneReport for Unigene cluster for RGS17 Gene Hs.166313

mRNA Expression by UniProt/SwissProt for RGS17 Gene

Q9UGC6-RGS17_HUMAN
Tissue specificity: Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.
genes like me logo Genes that share expressions with RGS17: view

Orthologs for RGS17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS17 36
  • 99.68 (n)
  • 100 (a)
RGS17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS17 36
  • 94.17 (n)
  • 98 (a)
RGS17 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS17 36
  • 94.6 (n)
  • 98.1 (a)
RGS17 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs17 36
  • 87.3 (n)
  • 91.9 (a)
Rgs17 16
Rgs17 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS17 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS17 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs17 36
  • 88.25 (n)
  • 93.81 (a)
chicken
(Gallus gallus)
Aves RGS17 36
  • 86.51 (n)
  • 92.86 (a)
RGS17 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS17 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs17 36
  • 79.05 (n)
  • 82.86 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs17 36
  • 65.1 (n)
  • 64.58 (a)
rgs17 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007127 36
  • 60.2 (n)
  • 61.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5036 36
  • 63.29 (n)
  • 65.94 (a)
CG5036 37
  • 40 (a)
OneToMany
EG:52C10.2 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rgs-1 37
  • 34 (a)
ManyToMany
rgs-2 37
  • 48 (a)
ManyToMany
Species with no ortholog for RGS17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS17 Gene

ENSEMBL:
Gene Tree for RGS17 (if available)
TreeFam:
Gene Tree for RGS17 (if available)

Paralogs for RGS17 Gene

Paralogs for RGS17 Gene

Selected SIMAP similar genes for RGS17 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RGS17 Gene

genes like me logo Genes that share paralogs with RGS17: view

Variants for RGS17 Gene

Sequence variations from dbSNP and Humsavar for RGS17 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs481251 -- 153,042,828(+) ACAAC(A/G)TTTTG intron-variant
rs486490 -- 153,015,761(+) ccatt(C/G)tcctg intron-variant
rs487560 -- 153,015,899(+) ctgcc(C/T)gcctc intron-variant
rs487972 -- 153,102,117(+) TAAGG(A/G)AAATG intron-variant
rs502415 -- 153,012,305(+) CTTCA(G/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS17 Gene

Variant ID Type Subtype PubMed ID
esv2732913 CNV Deletion 23290073
esv2732914 CNV Deletion 23290073
esv2732915 CNV Deletion 23290073
esv2667419 CNV Deletion 23128226
esv271146 CNV Insertion 20981092
esv273759 CNV Insertion 20981092
esv1484621 CNV Insertion 17803354

Relevant External Links for RGS17 Gene

HapMap Linkage Disequilibrium report
RGS17

Disorders for RGS17 Gene

Relevant External Links for RGS17

Genetic Association Database (GAD)
RGS17
Human Genome Epidemiology (HuGE) Navigator
RGS17
genes like me logo Genes that share disorders with RGS17: view

No data available for UniProtKB/Swiss-Prot for RGS17 Gene

Publications for RGS17 Gene

  1. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. (PMID: 15096504) Mao H. … Albert P.R. (J. Biol. Chem. 2004) 3 4 23
  2. Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. (PMID: 10419452) Jordan J.D. … Iyengar R. (J. Biol. Chem. 1999) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 49
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 49

Products for RGS17 Gene

Sources for RGS17 Gene

Back to Top

Content