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RGS17 Gene

protein-coding   GIFtS: 57
GCID: GC06M153331

Regulator Of G-Protein Signaling 17

(Previous name: regulator of G-protein signalling 17)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 171 2
Regulator Of G-Protein Signalling 171
RGS-172
RGSZ22
hRGS172

External Ids:    HGNC: 140881   Entrez Gene: 265752   Ensembl: ENSG000000918447   OMIM: 6071915   UniProtKB: Q9UGC63   

Export aliases for RGS17 gene to outside databases

Previous GC identifers: GC06M152892 GC06M153227 GC06M153286 GC06M153362 GC06M153423 GC06M150894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS17 Gene:
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120
amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity
of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein
(GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G
beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RGS17 Gene:
RGS17 (regulator of G-protein signaling 17) is a protein-coding gene. Diseases associated with RGS17 include substance dependence, and nicotine dependence. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS17_HUMAN, Q9UGC6
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits,
accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited
by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated
activation of the G-proteins (By similarity)

Gene Wiki entry for RGS17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS17 gene promoter:
         STAT1   Elk-1   AP-1   Pbx1a   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Egr-4   S8   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS17 promoter sequence
   Search Chromatin IP Primers for RGS17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q25-q26

RGS17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS17 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M153331:  view genomic region     (about GC identifiers)

Start:
153,325,594 bp from pter      End:
153,452,389 bp from pter
Size:
126,796 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGS17_HUMAN, Q9UGC6 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 17  
Size: 210 amino acids; 24359 Da
1 PDB 3D structure from and Proteopedia for RGS17:
1ZV4 (3D)    
Secondary accessions: Q5TF49 Q8TD61 Q9UJS8

Explore the universe of human proteins at neXtProt for RGS17: NX_Q9UGC6

Explore proteomics data for RGS17 at MOPED

Post-translational modifications: 

  • Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity)1
  • N- and O-glycosylated in synapsomal membranes (By similarity)1
  • Serine phosphorylated in synapsomal membranes (By similarity)1
  • Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid
    receptor-activated G(alpha) subunits (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036551.3  
    ENSEMBL proteins: 
     ENSP00000356194   ENSP00000206262  
    Reactome Protein details: Q9UGC6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry Q9UGC6

    ProtoNet protein and cluster: Q9UGC6

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS17_HUMAN, Q9UGC6
    Similarity: Contains 1 RGS domain


    RGS17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS17_HUMAN, Q9UGC6
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits,
    accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited
    by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated
    activation of the G-proteins (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
         
    RGS17 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RGS17:
     Decreased viability 

    Animal Models:
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    miRTarBase miRNAs that target RGS17:
    hsa-mir-32-5p (MIRT028374), hsa-mir-1 (MIRT024057)

    Block miRNA regulation of human, mouse, rat RGS17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGS17 (see all 20):
    hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-449a hsa-miR-20b* hsa-miR-548g hsa-miR-4293 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidRGS17 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGS17_HUMAN, Q9UGC6: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell
    membrane and the nucleus. Anchored to the membrane through palmitoylation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane3
    extracellular2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--

    RGS17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS17 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    4Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    5ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS17
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    2 BioSystems Pathways for RGS17
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell


    1 Reactome Pathway for RGS17
        G alpha (z) signalling events



    RGS17 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS17
    Interactions:

        Search GeneGlobe Interaction Network for RGS17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RGS17 (Q9UGC63 ENSP000002062624) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OSTM1Q86WC43, ENSP000001933224I2D: score=2 STRING: ENSP00000193322
    GNAZENSP000002489964STRING: ENSP00000248996
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity IBA--

    RGS17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS17



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RGS17 gene: 
    NM_012419.4  

    Unigene Cluster for RGS17:

    Regulator of G-protein signaling 17
    Hs.166313  [show with all ESTs]
    Unigene Representative Sequence: BC013117
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367225 ENST00000206262(uc003qpm.3)
    miRNA
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    hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-449a hsa-miR-20b* hsa-miR-548g hsa-miR-4293 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidRGS17 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF202257.3 AF493938.1 BC013117.1 BT006997.1 

    3 DOTS entries:

    DT.40226170  DT.75161133  DT.100747249 

    Selected AceView cDNA sequences (see all 35):

    BX116328 AF202257 CB152105 BF512313 BQ778157 BX494094 BU951427 AA902430 
    BU742403 AF493938 AI681252 BM718759 BI918279 AI916313 BC013117 BE789189 
    BI488621 BT006997 BG211245 BX111683 BQ776975 NM_012419 BU538795 BG699019 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAGAGCT
    RGS17 Expression
    About this image


    RGS17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    RGS17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.166313

    UniProtKB/Swiss-Prot: RGS17_HUMAN, Q9UGC6
    Tissue specificity: Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly
    expressed in a number of peripheral tissues notably spleen, lung and leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGS17 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs171 , 5 regulator of G-protein signaling 171, 5 87.3(n)1
    91.9(a)1
      10 (1.91 cM)5
    565331  NM_019958.41  NP_064342.11 
     58256635 
    chicken
    (Gallus gallus)
    Aves RGS171 regulator of G-protein signaling 17 86.51(n)
    92.86(a)
      395645  NM_204841.2  NP_990172.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS176
    regulator of G-protein signaling 17
    88(a)
    1 ↔ 1
    1(215714019-215795089)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rgs171 regulator of G-protein signaling 17 79.05(n)
    82.86(a)
      100488096  XM_004914668.1  XP_004914725.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgs171 regulator of G-protein signaling 17 65.1(n)
    64.58(a)
      436796  NM_001002523.2  NP_001002523.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:52C10.23
    CG50361
    regulation of G-protein coupled
    receptor protein more3
    CG50361
    67(a)3
    63.29(n)1
    65.94(a)1
      54E93
    370371  NM_137427.31  NP_611271.31 
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-26
    rgs-16
    Protein RGS-1, isoform b
    48(a)
    34(a)
    many ↔ many
    many ↔ many
    X(12712653-12728389) WBGene00004345
    III(10014593-10016534) WBGene00004344


    ENSEMBL Gene Tree for RGS17 (if available)
    TreeFam Gene Tree for RGS17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS17 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS162  RGS52  
    RGS12  RGS182  RGS132  RGS42  
    Selected SIMAP similar genes for RGS17 using alignment to 1 protein entry:     RGS17_HUMAN(see all similar genes):
    RGS20    RGS19    RGS18    RGS10    RGS21    RGS5
    RGS8    RGS1    RGS4    RGS13    RGS16    RGS7
    RGS6    RGS9    RGS11    RGS3    RGS2    RGS12

    RGS17 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RGS17
    PGOHUM00000248378


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS17 (see all 2386)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357040581,2
    C--150916524(+) AAAAA-/A/AA  
            
    GTCTA
    1 -- int11NA 2
    rs624359691,2
    C,F--151017843(+) CAAGGT/CATCTA 1 -- int17Minor allele frequency- C:0.15WA NA CSA EA 366
    rs1861909081,2
    --153331529(+) GCCTTG/TTAATG 1 -- ds50010--------
    rs2018038961,2
    --153331544(+) ATGAA-/AACT  
            
    AATAG
    1 -- ds50010--------
    rs1894319151,2
    --153331566(+) AAACAA/TCTTTA 1 -- ds50010--------
    rs1814402251,2
    --153331610(+) TTAAGA/GTCTGA 1 -- ds50010--------
    rs753805001,2
    C,F--153331623(+) TAGAGG/TATTAT 1 -- ds50013Minor allele frequency- T:0.06WA NA EA 358
    rs356567801,2
    C--153332035(+) TTTTGG/TTTTTT 1 -- ut310--------
    rs2001066531,2
    C--153332041(-) AAAAGA/CAAAAA 1 -- ut310--------
    rs1507134881,2
    C--153332053(+) GCATAC/GTAAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RGS17 (153325594 - 153452389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RGS17:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667419CNV Deletion23128226
    esv2732915CNV Deletion23290073
    esv2732914CNV Deletion23290073
    esv2732913CNV Deletion23290073
    esv1484621CNV Insertion17803354
    esv273759CNV Insertion20981092
    esv271146CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607191    OMIM disorders: --

    12 diseases for RGS17:    
    About MalaCards
    substance dependence    nicotine dependence    lung cancer susceptibility    esophagitis
    lung cancer    ovarian cancer    adenocarcinoma    hepatocellular carcinoma
    prostate cancer    prostatitis    pancreatitis    endotheliitis


    RGS17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS17
    Human Genome Epidemiology (HuGE) Navigator: RGS17 (9 documents)

    Export disorders for RGS17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS17 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with RGS17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. (PubMed id 15096504)1, 2, 9 Mao H.... Albert P.R. (J. Biol. Chem. 2004)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    6. Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. (PubMed id 19351763)1, 4 You M....Anderson M.W. (Clin. Cancer Res. 2009)
    7. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    8. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26575 HGNC: 14088 AceView: RGS17 Ensembl:ENSG00000091844 euGenes: HUgn26575
    ECgene: RGS17 H-InvDB: RGS17

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RGS17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS17 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RGS17 gene:
    Search GeneIP for patents involving RGS17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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