Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS17 Gene

Aliases for RGS17 Gene

  • Regulator Of G-Protein Signaling 17 2 3 5
  • RGSZ2 3 4
  • Regulator Of G-Protein Signalling 17 2
  • RGS-17 3
  • HRGS17 3

External Ids for RGS17 Gene

Previous GeneCards Identifiers for RGS17 Gene

  • GC06M152892
  • GC06M153227
  • GC06M153286
  • GC06M153362
  • GC06M153423
  • GC06M153331
  • GC06M150894

Summaries for RGS17 Gene

Entrez Gene Summary for RGS17 Gene

  • This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS17 Gene

RGS17 (Regulator Of G-Protein Signaling 17) is a Protein Coding gene. Diseases associated with RGS17 include substance dependence. Among its related pathways are Activation of cAMP-Dependent PKA and G-AlphaQ Signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS17 Gene

  • Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Gene Wiki entry for RGS17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS17 Gene

Genomics for RGS17 Gene

Regulatory Elements for RGS17 Gene

Enhancers for RGS17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGS17 on UCSC Golden Path with GeneCards custom track

Promoters for RGS17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGS17 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS17 Gene

Chromosome:
6
Start:
153,004,459 bp from pter
End:
153,131,254 bp from pter
Size:
126,796 bases
Orientation:
Minus strand

Genomic View for RGS17 Gene

Genes around RGS17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS17 Gene

Proteins for RGS17 Gene

  • Protein details for RGS17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGC6-RGS17_HUMAN
    Recommended name:
    Regulator of G-protein signaling 17
    Protein Accession:
    Q9UGC6
    Secondary Accessions:
    • Q5TF49
    • Q8TD61
    • Q9UJS8

    Protein attributes for RGS17 Gene

    Size:
    210 amino acids
    Molecular mass:
    24359 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAQ (PubMed:18434541). Interacts with GNAZ and GNAI2. Interacts with OPRM1. Forms a complex with mu-opioid receptors and G(alpha)z/i2 subunits, including GNAZ and GNAI2; the formation of this complex results in mu-opioid receptor desensitization (By similarity).

    Three dimensional structures from OCA and Proteopedia for RGS17 Gene

neXtProt entry for RGS17 Gene

Proteomics data for RGS17 Gene at MOPED

Post-translational modifications for RGS17 Gene

  • N- and O-glycosylated in synapsomal membranes.
  • Serine phosphorylated in synapsomal membranes.
  • Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RGS17 Gene

Domains & Families for RGS17 Gene

Gene Families for RGS17 Gene

Protein Domains for RGS17 Gene

Suggested Antigen Peptide Sequences for RGS17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGC6

UniProtKB/Swiss-Prot:

RGS17_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS17: view

Function for RGS17 Gene

Molecular function for RGS17 Gene

UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Gene Ontology (GO) - Molecular Function for RGS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with RGS17: view
genes like me logo Genes that share phenotypes with RGS17: view

Animal Model Products

miRNA for RGS17 Gene

miRTarBase miRNAs that target RGS17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS17 Gene

Localization for RGS17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS17 Gene

Membrane. Cell junction, synapse, synaptosome. Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS17 Gene COMPARTMENTS Subcellular localization image for RGS17 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RGS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0043005 neuron projection IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with RGS17: view

Pathways & Interactions for RGS17 Gene

genes like me logo Genes that share pathways with RGS17: view

Pathways by source for RGS17 Gene

Gene Ontology (GO) - Biological Process for RGS17 Gene

None

No data available for SIGNOR curated interactions for RGS17 Gene

Drugs & Compounds for RGS17 Gene

No Compound Related Data Available

Transcripts for RGS17 Gene

Unigene Clusters for RGS17 Gene

Regulator of G-protein signaling 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS17 Gene

No ASD Table

Relevant External Links for RGS17 Gene

GeneLoc Exon Structure for
RGS17
ECgene alternative splicing isoforms for
RGS17

Expression for RGS17 Gene

mRNA expression in normal human tissues for RGS17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS17 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.9) and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for RGS17 Gene

This gene is overexpressed in Heart (37.9) and Fetal Brain (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS17 Gene



SOURCE GeneReport for Unigene cluster for RGS17 Gene Hs.166313

mRNA Expression by UniProt/SwissProt for RGS17 Gene

Q9UGC6-RGS17_HUMAN
Tissue specificity: Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.
genes like me logo Genes that share expression patterns with RGS17: view

Protein tissue co-expression partners for RGS17 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RGS17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS17 35
  • 94.17 (n)
  • 98 (a)
RGS17 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS17 35
  • 94.6 (n)
  • 98.1 (a)
RGS17 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs17 35
  • 87.3 (n)
  • 91.9 (a)
Rgs17 16
Rgs17 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS17 35
  • 99.68 (n)
  • 100 (a)
RGS17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs17 35
  • 88.25 (n)
  • 93.81 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS17 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS17 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS17 35
  • 86.51 (n)
  • 92.86 (a)
RGS17 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS17 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs17 35
  • 79.05 (n)
  • 82.86 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs17 35
  • 65.1 (n)
  • 64.58 (a)
rgs17 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:52C10.2 37
  • 67 (a)
CG5036 35
  • 63.29 (n)
  • 65.94 (a)
CG5036 36
  • 40 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007127 35
  • 60.2 (n)
  • 61.82 (a)
worm
(Caenorhabditis elegans)
Secernentea rgs-1 36
  • 34 (a)
ManyToMany
rgs-2 36
  • 48 (a)
ManyToMany
Species with no ortholog for RGS17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS17 Gene

ENSEMBL:
Gene Tree for RGS17 (if available)
TreeFam:
Gene Tree for RGS17 (if available)

Paralogs for RGS17 Gene

Paralogs for RGS17 Gene

(19) SIMAP similar genes for RGS17 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RGS17 Gene

genes like me logo Genes that share paralogs with RGS17: view

Variants for RGS17 Gene

Sequence variations from dbSNP and Humsavar for RGS17 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1107036 -- 153,056,459(-) TCCAT(A/T)TATGG intron-variant
rs1281962 -- 153,110,241(+) ACAAC(C/G)AGTCC intron-variant
rs1281965 -- 153,114,131(+) aatca(A/G)tgaat intron-variant
rs1281967 -- 153,125,056(-) AAATT(A/T)TCTTG intron-variant
rs1281968 -- 153,125,626(+) CTTTG(A/G)GAGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RGS17 Gene

Variant ID Type Subtype PubMed ID
esv2732913 CNV Deletion 23290073
esv2732914 CNV Deletion 23290073
esv2732915 CNV Deletion 23290073
esv2667419 CNV Deletion 23128226
esv271146 CNV Insertion 20981092
esv273759 CNV Insertion 20981092
esv1484621 CNV Insertion 17803354

Variation tolerance for RGS17 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS17 Gene

HapMap Linkage Disequilibrium report
RGS17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS17 Gene

Disorders for RGS17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RGS17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
substance dependence
- elite association - COSMIC cancer census association via MalaCards
Search RGS17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGS17

Genetic Association Database (GAD)
RGS17
Human Genome Epidemiology (HuGE) Navigator
RGS17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS17
genes like me logo Genes that share disorders with RGS17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS17 Gene

Publications for RGS17 Gene

  1. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. (PMID: 15096504) Mao H. … Albert P.R. (J. Biol. Chem. 2004) 3 4 23 67
  2. Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. (PMID: 10419452) Jordan J.D. … Iyengar R. (J. Biol. Chem. 1999) 2 3
  3. CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human I^a88-adrenergic receptor. (PMID: 24561123) Kittanakom S. … Stagljar I. (Biochem. Biophys. Res. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for RGS17 Gene

Sources for RGS17 Gene

Content