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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGS17 Gene

protein-coding GIFtS: 56
GCID: GC06M153331

regulator of G-protein signaling 17

(Previous name: regulator of G-protein signalling 17 )

Explore 11 diseases affiliated with
RGS17 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 17¹ ²
RGS-17¹ ²
RGSZ2¹ ²
Regulator Of G-Protein Signalling 17¹
HRGS17¹

External Ids:	HGNC: 14088¹	Entrez Gene: 26575²	Ensembl: ENSG00000091844⁷	OMIM: 607191⁵	UniProtKB: Q9UGC6³

Export aliases for RGS17 gene to outside databases

Previous GC identifers: GC06M152892 GC06M153227 GC06M153286 GC06M153362 GC06M153423 GC06M150894

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS17:

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino

acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of

G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP),

increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma

subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: RGS17_HUMAN, Q9UGC6

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their

GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation

and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By

similarity)

Gene Wiki entry for RGS17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGS17 gene promoter:
STAT1 Elk-1 AP-1 Pbx1a AML1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Egr-4 S8
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS17 promoter sequence

Search SABiosciences Chromatin IP Primers for RGS17

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS17

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q25-q26

RGS17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS17 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M153331: view genomic region (about GC identifiers)

Start:	153,331,857 bp from pter	End:	153,452,389 bp from pter
Size:	120,533 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGS17_HUMAN, Q9UGC6 (See protein sequence)

Recommended Name: Regulator of G-protein signaling 17

Size: 210 amino acids; 24359 Da

Subcellular location: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and

the nucleus. Anchored to the membrane through palmitoylation (By similarity)

1 PDB 3D structure from and Proteopedia for RGS17:

1ZV4 (3D)

Secondary accessions: Q5TF49 Q8TD61 Q9UJS8

Explore the universe of human proteins at neXtProt for RGS17: NX_Q9UGC6

Post-translational modifications:

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity)¹

N- and O-glycosylated in synapsomal membranes (By similarity)¹

Serine phosphorylated in synapsomal membranes (By similarity)¹

Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid

receptor-activated G(alpha) subunits (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UGC6

RGS17 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036551.3

ENSEMBL proteins:

ENSP00000356194 ENSP00000206262

Human Recombinant Protein Products for RGS17:

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IBA	--
GO:0005886	plasma membrane	IBA	--

RGS17 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGS17 for domains About GeneDecksing

3 InterPro domains/families:

IPR024066 Regulat_G_prot_signal_dom1

IPR000342 Regulat_G_prot_signal

IPR016137 Regulat_G_prot_signal_superfam

Graphical View of Domain Structure for InterPro Entry Q9UGC6

ProtoNet protein and cluster: Q9UGC6

1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

UniProtKB/Swiss-Prot: RGS17_HUMAN, Q9UGC6

Similarity: Contains 1 RGS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RGS17_HUMAN, Q9UGC6

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their

GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation

and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By

similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IBA	--

RGS17 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RGS17:

Decreased viability

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RGS17

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS17

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-AlphaQ Signaling

G-AlphaQ Signaling

1.00

G-AlphaI Signaling

0.47

Calcium Regulation in the Cardiac Cell

Calcium Regulation in the Cardiac Cell

1.00

Myometrial Relaxation and Contraction Pathways

0.43

Activation of cAMP-Dependent PKA

cAMP Pathway

0.77

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS17

	cAMP Pathway
	G-AlphaI Signaling
	G-AlphaQ Signaling

2 BioSystems Pathways for RGS17

	Myometrial Relaxation and Contraction Pathways
	Calcium Regulation in the Cardiac Cell

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RGS17

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for RGS17 (Q9UGC6³ ENSP00000206262⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OSTM1	Q86WC4³, ENSP00000193322⁴	I2D: score=2 STRING: ENSP00000193322
GNAZ	ENSP00000248996⁴	STRING: ENSP00000248996
ADRA2A	ENSP00000280155⁴	STRING: ENSP00000280155
ADRA2B	ENSP00000387281⁴	STRING: ENSP00000387281
ADRA2C	ENSP00000386069⁴	STRING: ENSP00000386069

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0038032	termination of G-protein coupled receptor signaling pathway	IEA	--
GO:0043547	positive regulation of GTPase activity	IBA	--

RGS17 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGS17
Search CenterWatch for drugs/clinical trials and news about RGS17

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGS17 gene:

NM_012419.4

Unigene Cluster for RGS17:

Regulator of G-protein signaling 17

Hs.166313 [show with all ESTs]

Unigene Representative Sequence: BC013117

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367225 ENST00000206262(uc003qpm.3)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS17

Additional cDNA sequence:

AF202257.3 AF493938.1 BC013117.1 BT006997.1

3 DOTS entries:

DT.40226170 DT.75161133 DT.100747249

24/35 AceView cDNA sequences (see all 35):

AF493938 BF512313 AI681252 BU742403 BX494094 BU951427 AA902430 AF202257

CB152105 BQ778157 BM718759 BX116328 BI488621 BG211245 BI918279 BQ776975

NM_012419 BX111683 BC013117 AI916313 BE789189 BT006997 BG204943 BG219172

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGS17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAGAGCT

About this image

RGS17 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RGS17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGS17

SOURCE GeneReport for Unigene cluster: Hs.166313

UniProtKB/Swiss-Prot: RGS17_HUMAN, Q9UGC6

Tissue specificity: Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly

expressed in a number of peripheral tissues notably spleen, lung and leukocytes

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RGS17 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RGS17¹	regulator of G-protein signaling 17	86.51(n) 92.86(a)		395645 NM_204841.2 NP_990172.1
lizard (Anolis carolinensis)	Reptilia	RGS17⁶	--	81(a)	1 ↔ 1	1(215766965-215795089)
zebrafish (Danio rerio)	Actinopterygii	rgs17¹	regulator of G-protein signaling 17	66.84(n) 67.71(a)		436796 NM_001002523.1 NP_001002523.1
fruit fly (Drosophila melanogaster)	Insecta	EG:52C10.2³	regulation of G-protein coupled receptor protein more	67(a)		54E9 --
worm (Caenorhabditis elegans)	Secernentea	rgs-2⁶ rgs-1⁶ (see all 3)	Regulator of G-protein signaling rgs-1 (see all 3)	45(a) 31(a) (see all 3)	many ↔ many many ↔ many (see all 3)	X(12712580-12728319) III(10014503-10016444)

ENSEMBL Gene Tree for RGS17 (if available)
TreeFam Gene Tree for RGS17 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RGS17 gene

RGS2² RGS8² RGS19² RGS21² RGS3² RGS16² RGS20² RGS5²

RGS1² RGS18² RGS4² RGS13²

18/19 SIMAP similar genes for RGS17 using alignment to 1 protein entry: RGS17_HUMAN(see all similar genes):

RGS20 RGS19 RGS18 RGS10 RGS21 RGS5

RGS8 RGS1 RGS4 RGS13 RGS16 RGS7

RGS9 RGS6 RGS11 RGS3 RGS2 RGS12

RGS17 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RGS17
PGOHUM00000248378

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186190908^1,2		--	153331529(+)	`GCCTTG/TTAATG`	1	--	ds500¹		0	--	--	--	--
rs201803896^1,2		--	153331544(+)	`ATGAA-/AACT AATAG`	1	--	ds500¹		0	--	--	--	--
rs189431915^1,2		--	153331566(+)	`AAACAA/TCTTTA`	1	--	ds500¹		0	--	--	--	--
rs181440225^1,2		--	153331610(+)	`TTAAGA/GTCTGA`	1	--	ds500¹		0	--	--	--	--
rs75380500^1,2	C,F	--	153331623(+)	`TAGAGG/TATTAT`	1	--	ds500¹		3		WA NA EA	358
rs35656780^1,2	C	--	153332035(+)	`TTTTGG/TTTTTT`	1	--	ut3¹		0	--	--	--	--
rs200106653^1,2	C	--	153332041(-)	`AAAAGA/CAAAAA`	1	--	ut3¹		0	--	--	--	--
rs150713488^1,2		--	153332053(+)	`GCATAC/GTAAAC`	1	--	ut3¹		0	--	--	--	--
rs139111589^1,2		--	153332070(+)	`GTAATA/GAAAAT`	1	--	ut3¹		0	--	--	--	--
rs145095262^1,2		--	153332169(+)	`ATATTA/GGCTTC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RGS17 (153331857 - 153452389 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RGS17
1 CNV: 94117

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGS17

DNA2.0 Custom Variant and Variant Library Synthesis for RGS17

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RGS17 for disorders           About GeneDecksing

OMIM gene information: 607191    OMIM disorders: --

11 diseases for RGS17:    About MalaCards

lung cancer pulmonary disease hepatocellular carcinoma ovarian cancer

pharyngitis prostate cancer esophagitis prostatitis

adenocarcinoma carcinoma neuronitis

Human Genome Epidemiology (HuGE) Navigator: RGS17 (9 documents)

Export disorders for RGS17 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RGS17 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with RGS17)

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RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. (PubMed id 15096504)^{1, 2, 9} Mao H....Albert P.R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. (PubMed id 10419452)^{1, 3} Jordan J.D....Iyengar R. (1999)
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. (PubMed id 22591552)¹ Zhang H....Gelernter J. (2012)
Large-scale genome-wide association study of Asian pop ulation reveals genetic factors in FRMD4A and other loci influencing smoking ini tiation and nicotine dependence. (PubMed id 22006218)¹ Yoon D....Park T. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Altered expression and function of regulator of G-pro tein signaling-17 (RGS17) in hepatocellular carcinoma. (PubMed id 21620966)¹ Sokolov E....McKillop I.H. (2011)
Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)¹ Guey L.T....Malats N. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26575	HGNC: 14088	AceView: RGS17	Ensembl:ENSG00000091844	euGenes: HUgn26575
ECgene: RGS17	H-InvDB: RGS17

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RGS17	Pharmacogenomics, SNPs, Pathways

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Patent Information for RGS17 gene:
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regulator of G-protein signaling 17

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RGS17 Gene

regulator of G-protein signaling 17

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