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RGS16 Gene

protein-coding   GIFtS: 61
GCID: GC01M182567

Regulator Of G-Protein Signaling 16

(Previous name: regulator of G-protein signalling 16)
  See RGS16-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 161 2     hRGS-r2 3
Regulator Of G-Protein Signalling 161 2     A28-RGS142
Retinal-Specific RGS2 3     RGS-R2
Retinally Abundant Regulator Of G-Protein Signaling2 3     RGS-r3
A28-RGS14P2 3     RGSR3

External Ids:    HGNC: 99971   Entrez Gene: 60042   Ensembl: ENSG000001433337   OMIM: 6025145   UniProtKB: O154923   

Export aliases for RGS16 gene to outside databases

Previous GC identifers: GC01M180093 GC01M177996 GC01M179088 GC01M179807 GC01M179299 GC01M180835 GC01M153804


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS16 Gene:
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal
transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating
the kinetics of signaling in the phototransduction cascade. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS16 Gene:
RGS16 (regulator of G-protein signaling 16) is a protein-coding gene. Diseases associated with RGS16 include chordoid glioma. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS16_HUMAN, O15492
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May
play a role in regulating the kinetics of signaling in the phototransduction cascade

Gene Wiki entry for RGS16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS16 gene promoter:
         AhR   ER-alpha   Pbx1a   AP-1   ATF-2   AP-4   GATA-2   HNF-4alpha1   MZF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS16 promoter sequence
   Search Chromatin IP Primers for RGS16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25-q31   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25-q31

RGS16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS16 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M182567:  view genomic region     (about GC identifiers)

Start:
182,567,758 bp from pter      End:
182,573,548 bp from pter
Size:
5,791 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGS16_HUMAN, O15492 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 16  
Size: 202 amino acids; 22749 Da
2 PDB 3D structures from and Proteopedia for RGS16:
2BT2 (3D)        2IK8 (3D)    
Secondary accessions: B2R4M4 Q5VYN9 Q99701

Explore the universe of human proteins at neXtProt for RGS16: NX_O15492

Explore proteomics data for RGS16 at MOPED

Post-translational modifications: 

  • Palmitoylated on Cys-2 and/or Cys-12 (By similarity)1
  • Phosphorylated. Regulated by phosphorylation at Tyr-168 by EGFR upon stimulation by EGF1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002919.3  
    ENSEMBL proteins: 
     ENSP00000356529  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry O15492

    ProtoNet protein and cluster: O15492

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS16_HUMAN, O15492
    Similarity: Contains 1 RGS domain


    Find genes that share domains with RGS16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS16_HUMAN, O15492
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May
    play a role in regulating the kinetics of signaling in the phototransduction cascade
    Enzyme regulation: Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1

         Genatlas biochemistry entry for RGS16:
    negative regulator of G-protein signaling 16,23kDa,functioning as GTPase activating protein for G protein alpha i
    and q subunits,abundantly expressed in retina,p53 target gene,C elegans EGL-10 and yeast SST2 homolog

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding TAS10747990
         
    Find genes that share ontologies with RGS16           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rgs16):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     respiratory system 

    Find genes that share phenotypes with RGS16           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RGS16: Rgs16tm1Tmw Rgs16tm1.1Drue

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS16
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    miRTarBase miRNAs that target RGS16:
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    Block miRNA regulation of human, mouse, rat RGS16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RGS16 (see all 28):
    hsa-miR-4254 hsa-let-7d hsa-miR-3660 hsa-miR-202 hsa-miR-765 hsa-let-7c hsa-miR-4267 hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmidRGS16 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for RGS16 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    mitochondrion2
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--

    Find genes that share ontologies with RGS16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS16 About    
    See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    3Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    4EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS16
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    3 BioSystems Pathways for RGS16
        Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    Calcium Regulation in the Cardiac Cell



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS16
    Interactions:

        GeneGlobe Interaction Network for RGS16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for RGS16 (O154923 ENSP000003565294) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412403, ENSP000002200034I2D: score=3 STRING: ENSP00000220003
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    GNAO1P094713, ENSP000002624934I2D: score=2 STRING: ENSP00000262493
    GNAT1P114883, ENSP000002324614I2D: score=2 STRING: ENSP00000232461
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception TAS9469939
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS10747990
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS10747990

    Find genes that share ontologies with RGS16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS16

    8 Novoseek inferred chemical compound relationships for RGS16 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerophosphodiester 82 1 12576545 (1)
    glycerophosphoinositol 80.7 1 16472945 (1)
    gtp 48.7 4 11330340 (1), 16839744 (1), 11520900 (1)
    phosphoinositide 35.5 1 16472945 (1)
    5-hydroxytryptamine 22.5 1 12642592 (1)
    alanine 13.4 2 12642592 (1), 10791963 (1)
    cysteine 12.3 14 12642592 (6), 10373502 (3)
    tyrosine 7.16 9 11602604 (4), 12588871 (1)



    Find genes that share compounds with RGS16           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGS16 gene: 
    NM_002928.3  

    Unigene Cluster for RGS16:

    Regulator of G-protein signaling 16
    Hs.413297  [show with all ESTs]
    Unigene Representative Sequence: NM_002928
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367558(uc001gpl.4 uc010pnv.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RGS16 (see all 28):
    hsa-miR-4254 hsa-let-7d hsa-miR-3660 hsa-miR-202 hsa-miR-765 hsa-let-7c hsa-miR-4267 hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmidRGS16 3' UTR sequence
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    Additional mRNA sequence: 

    AF493937.1 AK301261.1 AK311880.1 BC006243.2 BT006638.1 U70426.1 U94829.1 

    12 DOTS entries:

    DT.415934  DT.92030809  DT.97795479  DT.121458604  DT.91666856  DT.40116728  DT.75179463  DT.40308213 
    DT.100645369  DT.75200340  DT.91826359  DT.92430023 

    Selected AceView cDNA sequences (see all 220):

    AI167621 BE792977 AI184384 AI446831 AA731420 AI304955 BU161050 AI168756 
    AW298681 BM676660 AA292532 BU172305 BE266216 BQ680811 Z41752 BM696147 
    BQ431705 AI934984 AW152400 BF431764 BM702133 BQ682997 AA626435 NM_002928 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RGS16    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                    -           -     -                     
    SP2:                    -           -     -                     
    SP3:                    -                                       
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for RGS16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATATTCTT
    RGS16 Expression
    About this image


    RGS16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Gonad
             Primordial Germ Cells Allantois
             Primordial germ cell-like cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
    RGS16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413297

    UniProtKB/Swiss-Prot: RGS16_HUMAN, O15492
    Tissue specificity: Abundantly expressed in retina with lower levels of expression in most other tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RGS16 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs161 , 5 regulator of G-protein signaling 161, 5 84.91(n)1
    85.07(a)1
      1 (65.43 cM)5
    197341  NM_011267.31  NP_035397.21 
     1537403495 
    chicken
    (Gallus gallus)
    Aves RGS161 regulator of G-protein signaling 16 75(n)
    71.02(a)
      424409  NM_001277544.1  NP_001264473.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS166
    regulator of G-protein signaling 16
    67(a)
    1 ↔ 1
    GL343683.1(36315-48348)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.327782 Xenopus laevis transcribed sequence with weak similarity more 76.14(n)    BJ094549.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgs5b1 regulator of G-protein signaling 5b 60(n)
    54.55(a)
      550519  NM_001017821.2  NP_001017821.1 


    ENSEMBL Gene Tree for RGS16 (if available)
    TreeFam Gene Tree for RGS16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS16 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS172  RGS52  
    RGS12  RGS182  RGS132  RGS42  
    Selected SIMAP similar genes for RGS16 using alignment to 1 protein entry:     RGS16_HUMAN(see all similar genes):
    RGS8    RGS4    RGS5    RGS2    RGS21    RGS3
    RGS17    RGS18    RGS1    RGS19    RGS13    RGS20
    RGS10    RGS6    RGS12    RGS9    RGS7    RGS14

    Find genes that share paralogs with RGS16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS16 (see all 168)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs773097561,2
    C,F--182567407(+) GCACTG/TTTACA 1 -- ds50011Minor allele frequency- T:0.05EA 120
    rs1914461851,2
    --182567438(+) ATGCCA/GAGTCC 1 -- ds50010--------
    rs46527331,2
    C,F,H--182567440(+) GCCGAG/ATCCCA 1 -- ds500121Minor allele frequency- A:0.21NS EA NA WA 2348
    rs1157475871,2
    F--182567489(+) GGGCTG/AAGCCC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs46527341,2
    C,F--182567519(+) CCCAAC/TACAAG 1 -- ds50011Minor allele frequency- T:0.07NA 120
    rs37954851,2
    C,F,A,H--182567739(-) AGTGCT/CGTGTG 1 -- ds500124Minor allele frequency- C:0.21EA NA NS WA 3104
    rs1836542331,2
    --182567856(+) CTCCAC/TTTGTC 1 -- ut310--------
    rs1879659191,2
    --182567963(+) GTCAGA/GCTGAA 1 -- ut310--------
    rs1420764891,2
    --182568029(+) ACAGCA/TCCAAC 1 -- ut310--------
    rs1512187561,2
    --182568112(+) GCTCAC/TGGTAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RGS16 (182567758 - 182573548 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RGS16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010175CNV Deletion20482838
    nsv825531CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS16
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602514    OMIM disorders: --

    1 disease for RGS16:    
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    chordoid glioma

    1 disease from the University of Copenhagen DISEASES database for RGS16:
    Chordoid glioma

    Find genes that share disorders with RGS16           About GenesLikeMe

    2 Novoseek inferred disease relationships for RGS16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 2 11104682 (2)
    tumors 0 7 18521847 (3), 19509421 (2)

    Genetic Association Database (GAD): RGS16
    Human Genome Epidemiology (HuGE) Navigator: RGS16 (5 documents)

    Export disorders for RGS16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS16 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with RGS16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene. (PubMed id 9469939)1, 2, 3, 9 Snow B.E.... Siderovski D.P. (Gene 1998)
    2. RGS16 function is regulated by epidermal growth factor receptor- mediated tyrosine phosphorylation. (PubMed id 11602604)1, 2, 9 Derrien A. and Druey K.M. (J. Biol. Chem. 2001)
    3. The p53 tumor suppressor targets a novel regulator of G protein signaling. (PubMed id 9223279)1, 2, 9 Buckbinder L.... Kley N. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    4. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PubMed id 18262772)1, 4, 9 Campbell D.B....Sullivan P.F. (Schizophr. Res. 2008)
    5. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (Carcinogenesis 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability. (PubMed id 12588871)1, 9 Derrien A....Druey K.M. (J. Biol. Chem. 2003)
    8. RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. (PubMed id 19509421)1, 9 Liang G....Druey K.M. (J. Biol. Chem. 2009)
    9. RGS16 is a marker for prognosis in colorectal cancer. (PubMed id 19760045)1, 9 Miyoshi N....Mori M. (Ann. Surg. Oncol. 2009)
    10. Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling. (PubMed id 12642592)1, 9 Osterhout J.L....Druey K.M. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6004 HGNC: 9997 AceView: RGS16 Ensembl:ENSG00000143333 euGenes: HUgn6004
    ECgene: RGS16 H-InvDB: RGS16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGS16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS16 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS16 gene:
    Search GeneIP for patents involving RGS16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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