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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS16 Gene

protein-coding   GIFtS: 57
GCID: GC01M182567

regulator of G-protein signaling 16

(Previous name: regulator of G-protein signalling 16 )
 Explore 18 diseases affiliated with
RGS16 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RGS16    

Aliases
for RGS16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Regulator Of G-Protein Signaling 161 2     Retinally Abundant Regulator Of G-Protein Signaling2 3
A28-RGS141 2     A28-RGS14P2 3
Regulator Of G-Protein Signalling 161 2     HRGS-R1
RGS-R2     RGS-R2
Retinal-Specific RGS2 3     RGSR3

External Ids:    HGNC: 99971   Entrez Gene: 60042   Ensembl: ENSG000001433337   OMIM: 6025145   UniProtKB: O154923   

Export aliases for RGS16 gene to outside databases

Previous GC identifers: GC01M180093 GC01M177996 GC01M179088 GC01M179807 GC01M179299 GC01M180835 GC01M153804


Summaries
for RGS16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RGS16:
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal
transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the
kinetics of signaling in the phototransduction cascade. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RGS16_HUMAN, O15492
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in
regulating the kinetics of signaling in the phototransduction cascade

Gene Wiki entry for RGS16


Genomic Views
for RGS16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS16 gene promoter:
         AhR   ER-alpha   Pbx1a   AP-1   ATF-2   AP-4   GATA-2   HNF-4alpha1   MZF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS16 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25-q31   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25-q31

RGS16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS16 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M182567:  view genomic region     (about GC identifiers)

Start:
 182,567,758 bp from pter      End:
 182,573,548 bp from pter
Size:
 5,791 bases      Orientation:
 minus strand

Proteins
for RGS16 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RGS16_HUMAN, O15492 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 16  
Size: 202 amino acids; 22749 Da
2 PDB 3D structures from and Proteopedia for RGS16:
2BT2 (3D)        2IK8 (3D)    
Secondary accessions: B2R4M4 Q5VYN9 Q99701

Explore the universe of human proteins at neXtProt for RGS16: NX_O15492

Post-translational modifications:

  • Palmitoylated on Cys-2 and/or Cys-12 (By similarity)1
  • Phosphorylated. Regulated by phosphorylation at Tyr-168 by EGFR upon stimulation by EGF1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15492

    • RGS16 Protein expression data from MOPED and PaxDb:    About this image 
    RGS16 Protein Expression
    REFSEQ proteins: NP_002919.3  
    ENSEMBL proteins: 
     ENSP00000356529  

    Human Recombinant Protein Products for RGS16: 
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    Novus Biologicals RGS16 Lysate
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    ProSpec Recombinant Protein for RGS16
    Uscn Proteins for RGS16

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--
    GO:0045121membrane raft ----

    RGS16 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RGS16

    Protein Domains /
    Families
    for RGS16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RGS16 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry O15492

    ProtoNet protein and cluster: O15492

    1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS16_HUMAN, O15492
    Similarity: Contains 1 RGS domain


    Function
    for RGS16 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS16_HUMAN, O15492
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving
    them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in
    regulating the kinetics of signaling in the phototransduction cascade
    Enzyme regulation: Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1

         Genatlas biochemistry entry for RGS16:
    negative regulator of G-protein signaling 16,23kDa,functioning as GTPase activating protein for G protein alpha i and q
    subunits,abundantly expressed in retina,p53 target gene,C elegans EGL-10 and yeast SST2 homolog

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding TAS10747990
         
    RGS16 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rgs16):
     cellular  homeostasis/metabolism  immune system  respiratory system 

    RGS16 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for RGS16: Rgs16tm1Tmw Rgs16tm1.1Drue
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RGS16 

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS16 (see all 28):
    hsa-miR-4254 hsa-let-7d hsa-miR-3660 hsa-miR-202 hsa-miR-765 hsa-let-7c hsa-miR-4267 hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmid: RGS16 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for RGS16 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-AlphaQ Signaling
    		G-AlphaQ Signaling1.00
    		G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    		Calcium Regulation in the Cardiac Cell1.00
    		Myometrial Relaxation and Contraction Pathways0.43
    3EGFR1 Signaling Pathway
    		EGFR1 Signaling Pathway1.00
    4Activation of cAMP-Dependent PKA
    		cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS16
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    3 BioSystems Pathways for RGS16 
        Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    Calcium Regulation in the Cardiac Cell


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for RGS16 (O154923 ENSP000003565294) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412403, ENSP000002200034I2D: score=3 STRING: ENSP00000220003
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    GNAO1P094713, ENSP000002624934I2D: score=2 STRING: ENSP00000262493
    GNAT1P114883, ENSP000002324614I2D: score=2 STRING: ENSP00000232461
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception TAS9469939
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS10747990
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS10747990

    RGS16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RGS16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS16 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RGS16
    8 Novoseek chemical compound relationships for RGS16 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerophosphodiester 82 1 12576545 (1)
    glycerophosphoinositol 80.7 1 16472945 (1)
    gtp 48.7 4 11330340 (1), 16839744 (1), 11520900 (1)
    phosphoinositide 35.5 1 16472945 (1)
    5-hydroxytryptamine 22.5 1 12642592 (1)
    alanine 13.4 2 12642592 (1), 10791963 (1)
    cysteine 12.3 14 12642592 (6), 10373502 (3)
    tyrosine 7.16 9 11602604 (4), 12588871 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS16 

    Transcripts
    for RGS16 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RGS16 gene: 
    NM_002928.3  

    Unigene Cluster for RGS16:

    Regulator of G-protein signaling 16
    Hs.413297  [show with all ESTs]
    Unigene Representative Sequence: NM_002928
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367558(uc001gpl.4 uc010pnv.1)

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS16 (see all 28):
    hsa-miR-4254 hsa-let-7d hsa-miR-3660 hsa-miR-202 hsa-miR-765 hsa-let-7c hsa-miR-4267 hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmid: RGS16 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF493937.1 AK301261.1 AK311880.1 BC006243.2 BT006638.1 U70426.1 U94829.1 

    12 DOTS entries:

    DT.415934  DT.92030809  DT.97795479  DT.121458604  DT.91666856  DT.40116728  DT.75179463  DT.40308213 
    DT.100645369  DT.75200340  DT.91826359  DT.92430023 

    24/220 AceView cDNA sequences (see all 220):

    BM702133 BF431764 AI934984 BE792977 AW152400 AA292532 AA731420 AA626435 
    BE266216 AI168756 AW298681 Z41752 BM696147 NM_002928 BU172305 AI304955 
    BU161050 BQ680811 BQ682997 BM676660 AI184384 AI167621 BQ431705 AI446831 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RGS16    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                    -           -     -                     
    SP2:                    -           -     -                     
    SP3:                    -                                       
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for RGS16

    Expression
    for RGS16 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTATATTCTT
    RGS16 Expression
    About this image

    RGS16 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Primordial germ cell-like cells (Reconstitution of mo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RGS16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS16

    SOURCE GeneReport for Unigene cluster: Hs.413297

    UniProtKB/Swiss-Prot: RGS16_HUMAN, O15492
    Tissue specificity: Abundantly expressed in retina with lower levels of expression in most other tissues

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    In Situ
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    Orthologs
    for RGS16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RGS16 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RGS161 regulator of G-protein signaling 16 73.55(n)
    69.57(a)    		   424409  XM_422252.3  XP_422252.3 
    lizard
    (Anolis carolinensis)    		 Reptilia RGS166
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL343683.1(39155-48021)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.327782 Xenopus laevis transcribed sequence with weak similarity more 76.14(n)    BJ094549.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rgs5b1 regulator of G-protein signaling 5b 59.33(n)
    53.57(a)    		   550519  NM_001017821.1  NP_001017821.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rgs-76
    rgs-46
    		 Regulator of G-protein signaling rgs-7
    Regulator of G protein Signaling family member (rg...
    		 7(a)
    21(a)
    		 1 ↔ many
    possible ortholog
    		 X(3542545-3557581)
    II(12667632-12671556)


    ENSEMBL Gene Tree for RGS16 (if available)
    TreeFam Gene Tree for RGS16 (if available) 

    Paralogs
    for RGS16 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS16 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS52  RGS172  
    RGS12  RGS182  RGS42  RGS132  
    18/19 SIMAP similar genes for RGS16 using alignment to 1 protein entry:     RGS16_HUMAN(see all similar genes):
    RGS8    RGS4    RGS5    RGS2    RGS21    RGS3
    RGS17    RGS18    RGS1    RGS19    RGS13    RGS20
    RGS10    RGS6    RGS12    RGS9    RGS7    RGS14

    RGS16 for paralogs           About GeneDecksing



    Genomic Variants
    for RGS16 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/137 NCBI SNPs in RGS16 are shown (see all 137)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs773097561,2
    		F--182567407(+) GCACTG/TTTACA 1 -- ds50011Minor allele frequency- T:0.05EA 120
    rs1914461851,2
    		--182567438(+) ATGCCA/GAGTCC 1 -- ds50010--------
    rs46527331,2
    		C,F,H--182567440(+) GCCGAG/ATCCCA 1 -- ds500121Minor allele frequency- A:0.21NS EA NA WA 2348
    rs1157475871,2
    		F--182567489(+) GGGCTG/AAGCCC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs46527341,2
    		F--182567519(+) CCCAAC/TACAAG 1 -- ds50011Minor allele frequency- T:0.07NA 120
    rs37954851,2
    		C,F,A,H--182567739(-) AGTGCT/CGTGTG 1 -- ds500124Minor allele frequency- C:0.21EA NA NS WA 3104
    rs1836542331,2
    		--182567856(+) CTCCAC/TTTGTC 1 -- ut310--------
    rs1879659191,2
    		--182567963(+) GTCAGA/GCTGAA 1 -- ut310--------
    rs1420764891,2
    		--182568029(+) ACAGCA/TCCAAC 1 -- ut310--------
    rs1512187561,2
    		--182568112(+) GCTCAC/TGGTAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RGS16 (182567758 - 182573548 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RGS16: --

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    Disorders / Diseases
    for RGS16 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RGS16 for disorders           About GeneDecksing

    OMIM gene information: 602514    OMIM disorders: --

    18 diseases for RGS16:    About MalaCards
    alpha 1-antitrypsin deficiency    retinitis    chordoid glioma    yaws
    pineoblastoma    acute lymphoblastic leukemia    lymphoblastic leukemia    burkitt's lymphoma
    squamous cell carcinoma    pancreatic cancer    breast carcinoma    colorectal cancer
    leukemia    breast cancer    pancreatitis    carcinoma
    neuroblastoma    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for RGS16:
    Chordoid glioma

    2 Novoseek disease relationships for RGS16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 2 11104682 (2)
    tumors 0 7 18521847 (3), 19509421 (2)

    Human Genome Epidemiology (HuGE) Navigator: RGS16 (5 documents)

    Export disorders for RGS16 gene to outside databases

    Publications
    for RGS16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS16 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with RGS16)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene. (PubMed id 9469939)1, 2, 3, 9 Snow B.E.... Siderovski D.P. (1998)
    2. RGS16 function is regulated by epidermal growth factor receptor- mediated tyrosine phosphorylation. (PubMed id 11602604)1, 2, 9 Derrien A. and Druey K.M. (2001)
    3. The p53 tumor suppressor targets a novel regulator of G protein signaling. (PubMed id 9223279)1, 2, 9 Buckbinder L.... Kley N. (1997)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability. (PubMed id 12588871)1, 9 Derrien A....Druey K.M. (2003)
    6. RGS16 inhibits breast cancer cell growth by mitigatin g phosphatidylinositol 3-kinase signaling. (PubMed id 19509421)1, 9 Liang G....Druey K.M. (2009)
    7. RGS16 is a marker for prognosis in colorectal cancer. (PubMed id 19760045)1, 9 Miyoshi N....Mori M. (2009)
    8. Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling. (PubMed id 12642592)1, 9 Osterhout J.L....Druey K.M. (2003)
    9. A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas. (PubMed id 18521847)1, 9 Wiechec E....Hansen L.L. (2008)
    10. Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling. (PubMed id 10373502)1, 9 Druey K.M....Jones T.L. (1999)

    External Searches for RGS16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    Genome Databases showing RGS16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6004 HGNC: 9997 AceView: RGS16 Ensembl:ENSG00000143333 euGenes: HUgn6004
    ECgene: RGS16 H-InvDB: RGS16

    Other Databases showing RGS16 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RGS16 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS16 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RGS16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RGS16 gene:
    Search GeneIP for patents involving RGS16

    GeneCards and IP:
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