Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS16 Gene

Aliases for RGS16 Gene

  • Regulator Of G-Protein Signaling 16 2 3
  • Retinally Abundant Regulator Of G-Protein Signaling 3 4
  • Regulator Of G-Protein Signalling 16 2 3
  • Retinal-Specific RGS 3 4
  • A28-RGS14P 3 4
  • HRGS-R 3 4
  • RGS-R 3 4
  • A28-RGS14 3
  • RGSR 4

External Ids for RGS16 Gene

Summaries for RGS16 Gene

Entrez Gene Summary for RGS16 Gene

  • The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS16 Gene

RGS16 (Regulator Of G-Protein Signaling 16) is a Protein Coding gene. Diseases associated with RGS16 include chordoid glioma. Among its related pathways are Activation of cAMP-Dependent PKA and G-AlphaQ Signaling. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS16 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade

Gene Wiki entry for RGS16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS16 Gene

Genomics for RGS16 Gene

Genomic Location for RGS16 Gene

Start:
182,598,623 bp from pter
End:
182,604,413 bp from pter
Size:
5,791 bases
Orientation:
Minus strand

Genomic View for RGS16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS16 Gene

Regulatory Elements for RGS16 Gene

Proteins for RGS16 Gene

  • Protein details for RGS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15492-RGS16_HUMAN
    Recommended name:
    Regulator of G-protein signaling 16
    Protein Accession:
    O15492
    Secondary Accessions:
    • B2R4M4
    • Q5VYN9
    • Q99701

    Protein attributes for RGS16 Gene

    Size:
    202 amino acids
    Molecular mass:
    22749 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS16 Gene

neXtProt entry for RGS16 Gene

Proteomics data for RGS16 Gene at MOPED

Post-translational modifications for RGS16 Gene

Other Protein References for RGS16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS16 Gene

Domains for RGS16 Gene

Gene Families for RGS16 Gene

HGNC:
  • RGS :Regulators of G-protein signaling

Protein Domains for RGS16 Gene

UniProtKB/Swiss-Prot:

RGS16_HUMAN
Domain:
  • Contains 1 RGS domain.:
    • O15492
genes like me logo Genes that share domains with RGS16: view

Function for RGS16 Gene

Molecular function for RGS16 Gene

GENATLAS Biochemistry: negative regulator of G-protein signaling 16,23kDa,functioning as GTPase activating protein for G protein alpha i and q subunits,abundantly expressed in retina,p53 target gene,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1
UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade

Gene Ontology (GO) - Molecular Function for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 21784977
GO:0005516 calmodulin binding TAS 10747990
genes like me logo Genes that share ontologies with RGS16: view
genes like me logo Genes that share phenotypes with RGS16: view

Animal Models for RGS16 Gene

MGI Knock Outs for RGS16:

miRNA for RGS16 Gene

miRTarBase miRNAs that target RGS16

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RGS16 Gene

Localization for RGS16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS16 Gene COMPARTMENTS Subcellular localization image for RGS16 gene
Compartment Confidence
cytosol 3
plasma membrane 3
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10791963
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS16: view

Pathways for RGS16 Gene

genes like me logo Genes that share pathways with RGS16: view

Pathways by source for RGS16 Gene

Gene Ontology (GO) - Biological Process for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 9469939
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10747990
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity TAS 10747990
genes like me logo Genes that share ontologies with RGS16: view

Compounds for RGS16 Gene

(8) Novoseek inferred chemical compound relationships for RGS16 Gene

Compound -log(P) Hits PubMed IDs
glycerophosphodiester 82 1
glycerophosphoinositol 80.7 1
gtp 48.7 3
phosphoinositide 35.5 1
5-hydroxytryptamine 22.5 1
genes like me logo Genes that share compounds with RGS16: view

Transcripts for RGS16 Gene

mRNA/cDNA for RGS16 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(220) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGS16 Gene

Regulator of G-protein signaling 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for RGS16 Gene

GeneLoc Exon Structure for
RGS16
ECgene alternative splicing isoforms for
RGS16

Expression for RGS16 Gene

mRNA expression in normal human tissues for RGS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS16 Gene

This gene is overexpressed in Thyroid (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RGS16 Gene

SOURCE GeneReport for Unigene cluster for RGS16 Gene Hs.413297

mRNA Expression by UniProt/SwissProt for RGS16 Gene

O15492-RGS16_HUMAN
Tissue specificity: Abundantly expressed in retina with lower levels of expression in most other tissues
genes like me logo Genes that share expressions with RGS16: view

Orthologs for RGS16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS16 36
  • 99.34 (n)
  • 99.01 (a)
RGS16 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS16 36
  • 87.29 (n)
  • 88.12 (a)
RGS16 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS16 36
  • 88.45 (n)
  • 88.12 (a)
RGS16 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs16 36
  • 84.91 (n)
  • 85.07 (a)
Rgs16 16
Rgs16 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS16 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS16 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs16 36
  • 84.76 (n)
  • 85.93 (a)
chicken
(Gallus gallus)
Aves RGS16 36
  • 75 (n)
  • 71.02 (a)
RGS16 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS16 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32778 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs16 36
  • 60.38 (n)
  • 49.71 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs16 37
  • 44 (a)
ManyToMany
rgs5b 36
  • 60 (n)
  • 54.55 (a)
Species with no ortholog for RGS16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS16 Gene

ENSEMBL:
Gene Tree for RGS16 (if available)
TreeFam:
Gene Tree for RGS16 (if available)

Paralogs for RGS16 Gene

Paralogs for RGS16 Gene

Selected SIMAP similar genes for RGS16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS16: view

Variants for RGS16 Gene

Sequence variations from dbSNP and Humsavar for RGS16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs509476 -- 182,604,092(+) TGCGC(C/T)TCTAC intron-variant
rs518844 -- 182,600,284(-) CTCCA(C/T)GGCAG utr-variant-3-prime
rs569790 -- 182,602,142(-) TTCCC(A/G)CAACC intron-variant
rs595069 -- 182,602,979(-) CCAGA(C/G)TCTCC intron-variant
rs597880 -- 182,603,740(+) AAGGA(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS16 Gene

Variant ID Type Subtype PubMed ID
nsv825531 CNV Loss 20364138
esv1010175 CNV Deletion 20482838

Relevant External Links for RGS16 Gene

HapMap Linkage Disequilibrium report
RGS16

Disorders for RGS16 Gene

(1) MalaCards Diseases for RGS16 Gene

Search for RGS16 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RGS16 Gene

(2) Novoseek inferred disease relationships for RGS16 Gene

Disease -log(P) Hits PubMed IDs
necrosis 0 2
tumors 0 5

Relevant External Links for RGS16

Genetic Association Database (GAD)
RGS16
Human Genome Epidemiology (HuGE) Navigator
RGS16
genes like me logo Genes that share disorders with RGS16: view

No data available for UniProtKB/Swiss-Prot for RGS16 Gene

Publications for RGS16 Gene

  1. Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene. (PMID: 9469939) Snow B.E. … Siderovski D.P. (Gene 1998) 2 3 4 23
  2. RGS16 function is regulated by epidermal growth factor receptor- mediated tyrosine phosphorylation. (PMID: 11602604) Derrien A. … Druey K.M. (J. Biol. Chem. 2001) 3 4 23
  3. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 23 49
  4. The p53 tumor suppressor targets a novel regulator of G protein signaling. (PMID: 9223279) Buckbinder L. … Kley N. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  5. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J. … Wu X. (Carcinogenesis 2010) 3 49

Products for RGS16 Gene

  • Addgene plasmids for RGS16

Sources for RGS16 Gene

Back to Top

Content