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Aliases for RGS16 Gene

Aliases for RGS16 Gene

  • Regulator Of G-Protein Signaling 16 2 3 5
  • Retinally Abundant Regulator Of G-Protein Signaling 3 4
  • Regulator Of G-Protein Signalling 16 2 3
  • Retinal-Specific RGS 3 4
  • A28-RGS14P 3 4
  • HRGS-R 3 4
  • RGS-R 3 4
  • A28-RGS14 3
  • RGSR 4

External Ids for RGS16 Gene

Previous GeneCards Identifiers for RGS16 Gene

  • GC01M180093
  • GC01M177996
  • GC01M179088
  • GC01M179807
  • GC01M179299
  • GC01M180835
  • GC01M182567
  • GC01M153804

Summaries for RGS16 Gene

Entrez Gene Summary for RGS16 Gene

  • The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS16 Gene

RGS16 (Regulator Of G-Protein Signaling 16) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and EGFR1 Signaling Pathway. GO annotations related to this gene include GTPase activator activity and calmodulin binding. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS16 Gene

  • Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).

Gene Wiki entry for RGS16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS16 Gene

Genomics for RGS16 Gene

Regulatory Elements for RGS16 Gene

Promoters for RGS16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGS16 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS16 Gene

Chromosome:
1
Start:
182,598,623 bp from pter
End:
182,604,413 bp from pter
Size:
5,791 bases
Orientation:
Minus strand

Genomic View for RGS16 Gene

Genes around RGS16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS16 Gene

Proteins for RGS16 Gene

  • Protein details for RGS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15492-RGS16_HUMAN
    Recommended name:
    Regulator of G-protein signaling 16
    Protein Accession:
    O15492
    Secondary Accessions:
    • B2R4M4
    • Q5VYN9
    • Q99701

    Protein attributes for RGS16 Gene

    Size:
    202 amino acids
    Molecular mass:
    22749 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAQ (PubMed:18434541). Interacts with GNAI2, GNAI3 and GNAO1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RGS16 Gene

neXtProt entry for RGS16 Gene

Proteomics data for RGS16 Gene at MOPED

Post-translational modifications for RGS16 Gene

  • Palmitoylated on Cys-2 and/or Cys-12.
  • Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS16 Gene

Domains & Families for RGS16 Gene

Gene Families for RGS16 Gene

Protein Domains for RGS16 Gene

Suggested Antigen Peptide Sequences for RGS16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15492

UniProtKB/Swiss-Prot:

RGS16_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS16: view

Function for RGS16 Gene

Molecular function for RGS16 Gene

GENATLAS Biochemistry:
negative regulator of G-protein signaling 16,23kDa,functioning as GTPase activating protein for G protein alpha i and q subunits,abundantly expressed in retina,p53 target gene,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).

Gene Ontology (GO) - Molecular Function for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 18434541
genes like me logo Genes that share ontologies with RGS16: view
genes like me logo Genes that share phenotypes with RGS16: view

Animal Models for RGS16 Gene

MGI Knock Outs for RGS16:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS16

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS16 Gene

Localization for RGS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS16 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS16 Gene COMPARTMENTS Subcellular localization image for RGS16 gene
Compartment Confidence
cytosol 4
plasma membrane 4
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0031224 intrinsic component of membrane ISS --
genes like me logo Genes that share ontologies with RGS16: view

Pathways & Interactions for RGS16 Gene

genes like me logo Genes that share pathways with RGS16: view

SIGNOR curated interactions for RGS16 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IDA,TAS 18434541
genes like me logo Genes that share ontologies with RGS16: view

Drugs & Compounds for RGS16 Gene

(4) Drugs for RGS16 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for RGS16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS16: view

Transcripts for RGS16 Gene

mRNA/cDNA for RGS16 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(220) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGS16 Gene

Regulator of G-protein signaling 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for RGS16 Gene

GeneLoc Exon Structure for
RGS16
ECgene alternative splicing isoforms for
RGS16

Expression for RGS16 Gene

mRNA expression in normal human tissues for RGS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS16 Gene

This gene is overexpressed in Thyroid (x4.4).

Protein differential expression in normal tissues from HIPED for RGS16 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS16 Gene



SOURCE GeneReport for Unigene cluster for RGS16 Gene Hs.413297

mRNA Expression by UniProt/SwissProt for RGS16 Gene

O15492-RGS16_HUMAN
Tissue specificity: Abundantly expressed in retina with lower levels of expression in most other tissues.
genes like me logo Genes that share expression patterns with RGS16: view

Protein tissue co-expression partners for RGS16 Gene

Primer Products

In Situ Assay Products

Orthologs for RGS16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS16 35
  • 87.29 (n)
  • 88.12 (a)
RGS16 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS16 35
  • 88.45 (n)
  • 88.12 (a)
RGS16 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs16 35
  • 84.91 (n)
  • 85.07 (a)
Rgs16 16
Rgs16 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS16 35
  • 99.34 (n)
  • 99.01 (a)
RGS16 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs16 35
  • 84.76 (n)
  • 85.93 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS16 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS16 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS16 35
  • 75 (n)
  • 71.02 (a)
RGS16 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS16 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs16 35
  • 60.38 (n)
  • 49.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32778 35
zebrafish
(Danio rerio)
Actinopterygii rgs5b 35
  • 60 (n)
  • 54.55 (a)
rgs16 36
  • 44 (a)
ManyToMany
Species with no ortholog for RGS16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS16 Gene

ENSEMBL:
Gene Tree for RGS16 (if available)
TreeFam:
Gene Tree for RGS16 (if available)

Paralogs for RGS16 Gene

Paralogs for RGS16 Gene

(19) SIMAP similar genes for RGS16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS16: view

Variants for RGS16 Gene

Sequence variations from dbSNP and Humsavar for RGS16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1144566 - 182,600,491(-) GACCC(A/C/G/T)CGAGC reference, missense
rs509476 -- 182,604,092(+) TGCGC(C/T)TCTAC intron-variant
rs518844 -- 182,600,284(-) CTCCA(C/T)GGCAG utr-variant-3-prime
rs611254 -- 182,604,484(-) GCCTT(C/T)TCAGC upstream-variant-2KB
rs569790 -- 182,602,142(-) TTCCC(A/G)CAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS16 Gene

Variant ID Type Subtype PubMed ID
nsv825531 CNV Loss 20364138
esv1010175 CNV Deletion 20482838

Variation tolerance for RGS16 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS16 Gene

HapMap Linkage Disequilibrium report
RGS16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS16 Gene

Disorders for RGS16 Gene

Relevant External Links for RGS16

Genetic Association Database (GAD)
RGS16
Human Genome Epidemiology (HuGE) Navigator
RGS16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS16

No disorders were found for RGS16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS16 Gene

Publications for RGS16 Gene

  1. Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene. (PMID: 9469939) Snow B.E. … Siderovski D.P. (Gene 1998) 2 3 4 23 67
  2. RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. (PMID: 19509421) Liang G. … Druey K.M. (J. Biol. Chem. 2009) 3 23
  3. RGS16 is a marker for prognosis in colorectal cancer. (PMID: 19760045) Miyoshi N. … Mori M. (Ann. Surg. Oncol. 2009) 3 23
  4. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell D.B. … Sullivan P.F. (Schizophr. Res. 2008) 3 23
  5. A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas. (PMID: 18521847) Wiechec E. … Hansen L.L. (Genes Chromosomes Cancer 2008) 3 23

Products for RGS16 Gene

Sources for RGS16 Gene

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