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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS14 Gene

protein-coding   GIFtS: 61
GCID: GC05P176784

Regulator Of G-Protein Signaling 14

(Previous name: regulator of G-protein signalling 14)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 141 2
Regulator Of G-Protein Signalling 141 2

External Ids:    HGNC: 99961   Entrez Gene: 106362   Ensembl: ENSG000001692207   OMIM: 6025135   UniProtKB: O435663   

Export aliases for RGS14 gene to outside databases

Previous GC identifers: GC05P177158 GC05P177627 GC05P176720 GC05P176765 GC05P176717 GC05P171705


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS14 Gene:
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain,
two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of
G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits.
Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This
hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein
heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been
observed but have not been thoroughly characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS14 Gene: 
RGS14 (regulator of G-protein signaling 14) is a protein-coding gene. Diseases associated with RGS14 include multiple system atrophy, and nephrolithiasis, and among its related super-pathways are G-AlphaQ Signaling and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include microtubule binding and protein kinase binding. An important paralog of this gene is RGS11.

UniProtKB/Swiss-Prot: RGS14_HUMAN, O43566
Function: Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange
and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein
alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity
on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers
GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold
integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor
(PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is
reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle
organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the
nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and
hippocampal-based learning and memory

Gene Wiki entry for RGS14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS14 gene promoter:
         RFX1   AML1a   RREB-1   STAT5A   Nkx2-5   Ik-3   LCR-F1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS14 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RGS14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS14 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176784:  view genomic region     (about GC identifiers)

Start:
176,784,838 bp from pter      End:
176,799,602 bp from pter
Size:
14,765 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGS14_HUMAN, O43566 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 14  
Size: 566 amino acids; 61447 Da
Subunit: Interacts with GNAO1 and GNAI2. Interacts (via RGS and GoLoco domains) GNAI1; the interaction occurs in
the centrosomes. Interacts with RABGEF1; the interactions is GTP-dependent. Interacts with RAP2A; the
interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI.
Associates with microtubules. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts
with RIC8A (via C-terminus). Interacts (via RBD 1 domain) with HRAS1 (active GTP-bound form preferentially).
Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary
complex with RAF1. Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation
of a ternary complex with BRAF. Interacts with KRAS (active GTP-bound form preferentially), MRAS (active
GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form
preferentially). Interacts with GNAI1 (via active GTP- or inactive GDP-bound forms); the interaction prevents
association of RGS14 with centrosomes or nuclear localization. Interacts with GNAI2. Interacts with GNAI3 (via
active GTP- or inactive GDP-bound forms); the interaction prevents association of RGS14 with centrosomes or
nuclear localization (By similarity). Associates with microtubules
Subcellular location: Nucleus (By similarity). Nucleus, PML body (By similarity). Cytoplasm. Membrane (By
similarity). Cell membrane (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
(By similarity). Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole (By similarity). Cell
projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse,
postsynaptic cell membrane, postsynaptic density (By similarity). Note=Associates with the perinuclear sheaths of
microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and
subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo.
Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus
during interphase and segregates to the centrosomes and astral MTs during mitosis. Relocalizes to the nucleus in
PML nuclear bodies in response to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. Localizes to
spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited
from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3.
Recruited from the cytosol to membranes by the active GTP-bound form of HRAS1. Colocalizes with G(i) alpha
subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and
membranes (By similarity)
Sequence caution: Sequence=AAB92614.1; Type=Frameshift; Positions=337, 344, 348, 539, 544;
5 PDB 3D structures from and Proteopedia for RGS14:
2JNU (3D)        2OM2 (3D)        2XNS (3D)        3ONW (3D)        3QI2 (3D)    
Secondary accessions: O43565 Q506M1 Q6ZWA4 Q8TD62
Alternative splicing: 4 isoforms:  O43566-7   O43566-4   O43566-5   O43566-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGS14: NX_O43566

Explore proteomics data for RGS14 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on
    G(i) alpha subunit GNAI1 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43566

  • RGS14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGS14 Protein Expression
    REFSEQ proteins: NP_006471.2  
    ENSEMBL proteins: 
     ENSP00000386229   ENSP00000422329  

    Human Recombinant Protein Products for RGS14: 
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    Novus Biologicals RGS14 Proteins
    Novus Biologicals RGS14 Lysates
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    ProSpec Recombinant Protein for RGS14
    Cloud-Clone Corp. Proteins for RGS14 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole ISS--
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005813centrosome ISS--

    RGS14 for ontologies           About GeneDecksing



    RGS14 Antibody Products: 
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    Assay Products for RGS14: 
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    Cloud-Clone Corp. ELISAs for RGS14 
    Cloud-Clone Corp. CLIAs for RGS14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RGS: Regulators of G-protein signaling

    5 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR003116 Raf-like_ras-bd
     IPR003109 GoLoco_motif
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry O43566

    ProtoNet protein and cluster: O43566

    3 Blocks protein domains:
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB003109 G-alpha GTPase activator
    IPB003116 Raf-like Ras-binding


    UniProtKB/Swiss-Prot: RGS14_HUMAN, O43566
    Domain: The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization
    to the nucleus and centrosomes (By similarity)
    Domain: The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the
    nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3 (By similarity)
    Domain: The RBD domains are necessary for localization to the nucleus and centrosomes (By similarity)
    Similarity: Contains 1 GoLoco domain
    Similarity: Contains 2 RBD (Ras-binding) domains
    Similarity: Contains 1 RGS domain


    RGS14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS14_HUMAN, O43566
    Function: Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange
    and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein
    alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity
    on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers
    GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold
    integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor
    (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is
    reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle
    organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the
    nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and
    hippocampal-based learning and memory

         Genatlas biochemistry entry for RGS14:
    negative regulator of G protein signaling 14,functioning as GTPase-activating protein for G protein alpha i and q
    subunits with multiple transcripts,highly expressed in brain,lung,spleen,C elegans EGL-10 and yeast SST2 homolog

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity ISS--
    GO:0005092GDP-dissociation inhibitor activity IDA15917656
    GO:0005096GTPase activator activity IDA15917656
    GO:0005515protein binding ----
    GO:0008017microtubule binding IDA15917656
         
    RGS14 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RGS14:
     Decreased cilium length  Decreased cilium length after   Decreased nuclei size in G2M  Decreased viability with pacli 

         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rgs14):
     behavior/neurological  cardiovascular system  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     reproductive system  skeleton  vision/eye 

    RGS14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rgs14tm1Pngr for RGS14

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGS14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGS14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGS14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGS14 

    miRNA
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    hsa-miR-22 hsa-miR-485-5p hsa-miR-3184 hsa-miR-374b hsa-miR-324-3p hsa-miR-487a hsa-miR-485-3p hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidRGS14 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGS14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    3Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    4G-protein signaling G-Protein alpha-i signaling cascades
    G-protein signaling G-Protein alpha-i signaling cascades0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RGS14
        G-protein signaling G-Protein alpha-i signaling cascades

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS14
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    1 GeneGo (Thomson Reuters) Pathway for RGS14
        G-protein signaling G-Protein alpha-i signaling cascades

    2 BioSystems Pathways for RGS14
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell



    RGS14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/144 Interacting proteins for RGS14 (O435662, 3 ENSP000003862294) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    CSF1P096033, ENSP000003275134I2D: score=1 STRING: ENSP00000327513
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    GNAI3P087543, ENSP000003588674I2D: score=3 STRING: ENSP00000358867
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006913nucleocytoplasmic transport ISS--
    GO:0006979response to oxidative stress ISS--
    GO:0007051spindle organization IMP15917656
    GO:0007059chromosome segregation ISS--
    GO:0007067mitosis IEA--

    RGS14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS14

    2 Novoseek inferred chemical compound relationships for RGS14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 56 2 15520006 (1), 11976690 (1)
    gtp 51.7 2 19319189 (1), 16246175 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGS14 gene: 
    NM_006480.4  

    Unigene Cluster for RGS14:

    Regulator of G-protein signaling 14
    Hs.9347  [show with all ESTs]
    Unigene Representative Sequence: NM_006480
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000408923(uc003mgf.3 uc003mgh.3) ENST00000504631 ENST00000514713(uc003mgg.1)
    ENST00000511890 ENST00000503110 ENST00000512000 ENST00000512490 ENST00000425155(uc003mgi.3)
    ENST00000502731 ENST00000514102 ENST00000509289 ENST00000503044 ENST00000506944

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    Additional mRNA sequence: 

    AF037194.1 AF037195.1 AF493936.1 AK123382.1 AY987041.1 BC014094.2 

    11 DOTS entries:

    DT.212988  DT.100763695  DT.97846434  DT.95173747  DT.100720015  DT.95173745  DT.100763698  DT.95173746 
    DT.95299698  DT.102824882  DT.86843065 

    24/173 AceView cDNA sequences (see all 173):

    CR607607 AI984838 BU553314 AK098150 BQ052317 CB053919 BM784142 BM930017 
    F13091 BM742141 AL043476 AA312674 F02018 BM784996 AW519070 F10685 
    BM764979 BM547650 BM783481 NM_006480 BM752988 AW780279 BM906459 AI433462 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for RGS14 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
    SP1:              -                       -     -     -     -           -                 -                       -           -                       -         
    SP2:                                      -     -     -     -           -                 -                       -           -                       -         
    SP3:                                                                    -                 -                       -           -                       -         
    SP4:                                                                                                              -           -                       -         
    SP5:                                      -     -     -     -           -                 -                                                                     

    ExUns: 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e · 14f
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for RGS14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS14 expression in normal human tissues (normalized intensities)      RGS14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGATGGC
    RGS14 Expression
    About this image


    RGS14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             caudate nucleus   
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Blood (Hematopoietic System)
             neutrophils   
     
     Stomach (Gastrointestinal Tract)

    See RGS14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS14

    SOURCE GeneReport for Unigene cluster: Hs.9347
        SABiosciences Custom PCR Arrays for RGS14
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGS14 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs141 , 5 regulator of G-protein signaling 141, 5 85.57(n)1
    88.44(a)1
      13 (29.80 cM)5
    517911  NM_016758.31  NP_058038.21 
     553697325 
    chicken
    (Gallus gallus)
    Aves RGS141 regulator of G-protein signaling 14 65.04(n)
    61.33(a)
      769193  XM_001231917.2  XP_001231918.2 
    lizard
    (Anolis carolinensis)
    Reptilia RGS146
    regulator of G-protein signaling 14
    54(a)
    1 ↔ 1
    2(146011676-146037627)
    zebrafish
    (Danio rerio)
    Actinopterygii rgs14a6
    RGS14 (1 of 2)6
    regulator of G-protein signaling 14
    38(a)
    36(a)
    many → 1
    many → 1
    14(871151-897205)
    21(31862671-31888821)
    fruit fly
    (Drosophila melanogaster)
    Insecta loco6
    locomotion defects
    10(a)
    1 → many
    3R(18445690-18465082)
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-46
    Protein RGS-4, isoform a
    23(a)
    possible ortholog
    II(12667698-12671623)


    ENSEMBL Gene Tree for RGS14 (if available)
    TreeFam Gene Tree for RGS14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS14 gene
    RGS112  RGS122  RGS102  RGS72  RGS62  RGS92  
    10 SIMAP similar genes for RGS14 using alignment to 2 protein entries:     RGS14_HUMAN (see all proteins):
    DKFZp761K1617    RGS4    RGS12    RGS17    RGS5    RGS8
    RGS2    RGS13    RGS18    RGS16

    RGS14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 SNPs in RGS14 are shown (see all 347)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494421881,2
    --176782942(+) CACATC/TTTCAA 1 -- us2k10--------
    rs1833414941,2
    --176783185(+) GGCTCA/CCACTT 1 -- us2k10--------
    rs715856321,2
    C--176783282(+) TCTAC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1885512281,2
    --176783329(+) CCCAGA/CTACTT 1 -- us2k10--------
    rs597832651,2
    C--176783446(+) AAAAG-/ATAAAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1914935381,2
    --176783685(+) CACCCC/TTCAGC 1 -- us2k10--------
    rs1838061551,2
    C--176783739(+) CATACA/GTTGAA 1 -- us2k10--------
    rs733304601,2
    C,F--176783857(+) AGACAG/CGAGGG 1 -- us2k12Minor allele frequency- C:0.14WA 120
    rs760758881,2
    C,F--176783893(+) CTATCG/ATGAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1447650501,2
    --176783958(+) CAGATA/GTGCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGS14 (176784838 - 176799602 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RGS14:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509103CNV Insertion20534489
    nsv471057CNV Loss18288195
    nsv883164CNV Loss21882294
    dgv6380n71CNV Loss21882294
    nsv883163CNV Loss21882294
    dgv6379n71CNV Loss21882294
    nsv5146CNV Loss18451855
    dgv733n27CNV Loss19166990
    nsv428132CNV Gain18775914
    dgv1878e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602513    OMIM disorders: --

    10 diseases for RGS14:    About MalaCards
    multiple system atrophy    nephrolithiasis    kidney disease    kaposi's sarcoma
    colon cancer    multiple sclerosis    sarcoma    squamous cell carcinoma
    neuronitis    leukemia


    RGS14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS14
    Human Genome Epidemiology (HuGE) Navigator: RGS14 (1 document)

    Export disorders for RGS14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS14 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with RGS14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PubMed id 17635935)1, 2, 9 Cho H. and Kehrl J.H. (2007)
    2. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. (PubMed id 22396660)1, 4 Urabe Y....Matsuda K. (2012)
    3. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (2011)
    4. Genetic variations in regulator of G-protein signalin g genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (2010)
    5. Structure-based protocol for identifying mutations th at enhance protein-protein binding affinities. (PubMed id 17603074)1, 2 Sammond D.W....Kuhlman B. (2007)
    6. RGS14 is a microtubule-associated protein. (PubMed id 15917656)1, 2 Martin-McCaffrey L....D'Souza S.J. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. (PubMed id 19878719)1, 9 Shu F.J....Hepler J.R. (2010)
    10. Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. (PubMed id 12534294)1, 9 Hollinger S....Hepler J.R. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10636 HGNC: 9996 AceView: RGS14 Ensembl:ENSG00000169220 euGenes: HUgn10636
    ECgene: RGS14 H-InvDB: RGS14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS14 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt132.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGS14 gene:
    Search GeneIP for patents involving RGS14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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