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Aliases for RGS14 Gene

Aliases for RGS14 Gene

  • Regulator Of G-Protein Signaling 14 2 3 5
  • Regulator Of G-Protein Signalling 14 2

External Ids for RGS14 Gene

Previous GeneCards Identifiers for RGS14 Gene

  • GC05P177158
  • GC05P177627
  • GC05P176720
  • GC05P176765
  • GC05P176717
  • GC05P176784
  • GC05P171705

Summaries for RGS14 Gene

Entrez Gene Summary for RGS14 Gene

  • This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS14 Gene

RGS14 (Regulator Of G-Protein Signaling 14) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and G-protein signaling G-Protein alpha-i signaling cascades. GO annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot for RGS14 Gene

  • Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Gene Wiki entry for RGS14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS14 Gene

Genomics for RGS14 Gene

Regulatory Elements for RGS14 Gene

Enhancers for RGS14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGS14 on UCSC Golden Path with GeneCards custom track

Promoters for RGS14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGS14 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS14 Gene

Chromosome:
5
Start:
177,357,711 bp from pter
End:
177,372,601 bp from pter
Size:
14,891 bases
Orientation:
Plus strand

Genomic View for RGS14 Gene

Genes around RGS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS14 Gene

Proteins for RGS14 Gene

  • Protein details for RGS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43566-RGS14_HUMAN
    Recommended name:
    Regulator of G-protein signaling 14
    Protein Accession:
    O43566
    Secondary Accessions:
    • O43565
    • Q506M1
    • Q6ZWA4
    • Q8TD62

    Protein attributes for RGS14 Gene

    Size:
    566 amino acids
    Molecular mass:
    61447 Da
    Quaternary structure:
    • Interacts with GNAO1, GNAI2 and GNAI3 (By similarity). Interacts with GNAI1 (PubMed:18434541, PubMed:21115486). Interacts (via RGS and GoLoco domains) with GNAI1; the interaction occurs in the centrosomes. Interaction with GNAI1 or GNAI3 (via active GTP- or inactive GDP-bound forms) prevents association of RGS14 with centrosomes or nuclear localization (By similarity). Interacts with RABGEF1; the interactions is GTP-dependent. Interacts with RAP2A; the interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI (By similarity). Associates with microtubules (PubMed:15917656). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts with RIC8A (via C-terminus). Interacts (via RBD 1 domain) with HRAS (active GTP-bound form preferentially). Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1. Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF. Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially).
    SequenceCaution:
    • Sequence=AAB92614.1; Type=Frameshift; Positions=337, 344, 348, 539, 544; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGS14 Gene

    Alternative splice isoforms for RGS14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS14 Gene

Proteomics data for RGS14 Gene at MOPED

Post-translational modifications for RGS14 Gene

  • Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS14 Gene

Domains & Families for RGS14 Gene

Gene Families for RGS14 Gene

Suggested Antigen Peptide Sequences for RGS14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43566

UniProtKB/Swiss-Prot:

RGS14_HUMAN :
  • The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.
Domain:
  • The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.
  • The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3.
  • The RBD domains are necessary for localization to the nucleus and centrosomes.
  • Contains 1 GoLoco domain.
  • Contains 2 RBD (Ras-binding) domains.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS14: view

Function for RGS14 Gene

Molecular function for RGS14 Gene

GENATLAS Biochemistry:
negative regulator of G protein signaling 14,functioning as GTPase-activating protein for G protein alpha i and q subunits with multiple transcripts,highly expressed in brain,lung,spleen,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.
genes like me logo Genes that share phenotypes with RGS14: view

Animal Models for RGS14 Gene

MGI Knock Outs for RGS14:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS14

miRNA for RGS14 Gene

miRTarBase miRNAs that target RGS14

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS14 Gene

Localization for RGS14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS14 Gene

Nucleus. Nucleus, PML body. Cytoplasm. Membrane. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Relocalizes to the nucleus in PML nuclear bodies in response to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. Localizes to spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS14 Gene COMPARTMENTS Subcellular localization image for RGS14 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for RGS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005819 spindle IEA,IDA 15917656
GO:0014069 postsynaptic density IEA,ISS --
GO:0016605 PML body IEA --
GO:0030425 dendrite IEA,ISS --
genes like me logo Genes that share ontologies with RGS14: view

Pathways & Interactions for RGS14 Gene

genes like me logo Genes that share pathways with RGS14: view

Pathways by source for RGS14 Gene

Gene Ontology (GO) - Biological Process for RGS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA,ISS --
GO:0007059 chromosome segregation IEA,ISS --
GO:0007165 signal transduction IEA --
GO:0007612 learning IEA,ISS --
GO:0008542 visual learning IEA,ISS --
genes like me logo Genes that share ontologies with RGS14: view

No data available for SIGNOR curated interactions for RGS14 Gene

Drugs & Compounds for RGS14 Gene

(2) Additional Compounds for RGS14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS14: view

Transcripts for RGS14 Gene

Unigene Clusters for RGS14 Gene

Regulator of G-protein signaling 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS14 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: -
SP8: - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: -
SP12:
SP13:
SP14: -
SP15:

ExUns: 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e · 14f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13: - -
SP14:
SP15:

Relevant External Links for RGS14 Gene

GeneLoc Exon Structure for
RGS14
ECgene alternative splicing isoforms for
RGS14

Expression for RGS14 Gene

mRNA expression in normal human tissues for RGS14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS14 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x9.8), Whole Blood (x8.4), Brain - Caudate (basal ganglia) (x7.7), and Brain - Nucleus accumbens (basal ganglia) (x7.2).

Protein differential expression in normal tissues from HIPED for RGS14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.3), Brain (14.8), CD8 Tcells (10.8), and Monocytes (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS14 Gene



SOURCE GeneReport for Unigene cluster for RGS14 Gene Hs.9347

genes like me logo Genes that share expression patterns with RGS14: view

Protein tissue co-expression partners for RGS14 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RGS14 Gene

Orthologs for RGS14 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS14 35
  • 88.63 (n)
  • 90.59 (a)
RGS14 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS14 35
  • 87.94 (n)
  • 88.65 (a)
RGS14 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs14 35
  • 85.57 (n)
  • 88.44 (a)
Rgs14 16
Rgs14 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS14 35
  • 99.29 (n)
  • 99.29 (a)
RGS14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs14 35
  • 85.24 (n)
  • 87.64 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS14 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS14 35
  • 66.4 (n)
  • 63.53 (a)
RGS14 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS14 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490892 35
  • 61.58 (n)
  • 59.96 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs14a 35
  • 53.6 (n)
  • 46.54 (a)
RGS14 (2 of 2) 36
  • 37 (a)
OneToMany
rgs14a 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta loco 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-7 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
-- 36
  • 17 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 10 (a)
ManyToMany
CSA.611 36
  • 24 (a)
ManyToMany
CSA.611 36
  • 23 (a)
ManyToMany
CSA.7262 36
  • 18 (a)
ManyToMany
Species with no ortholog for RGS14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS14 Gene

ENSEMBL:
Gene Tree for RGS14 (if available)
TreeFam:
Gene Tree for RGS14 (if available)

Paralogs for RGS14 Gene

Paralogs for RGS14 Gene

(10) SIMAP similar genes for RGS14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS14: view

Variants for RGS14 Gene

Sequence variations from dbSNP and Humsavar for RGS14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1127682 -- 177,367,762(+) AGGAG(C/T)TGGGG reference, synonymous-codon
rs4074995 -- 177,370,342(+) TTCTC(A/G)TAATT intron-variant
rs4075958 -- 177,357,511(+) GTGCC(A/G)AGTAA upstream-variant-2KB
rs4075959 -- 177,357,611(+) TACTC(A/G)TGTGC upstream-variant-2KB
rs4075960 -- 177,357,612(+) ACTCG(C/T)GTGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RGS14 Gene

Variant ID Type Subtype PubMed ID
dgv1878e1 CNV Complex 17122850
nsv428132 CNV Gain 18775914
dgv6379n71 CNV Loss 21882294
nsv509103 CNV Insertion 20534489
nsv471057 CNV Loss 18288195
dgv6380n71 CNV Loss 21882294
nsv883163 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv733n27 CNV Loss 19166990
nsv5146 CNV Loss 18451855

Variation tolerance for RGS14 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RGS14 Gene

Disorders for RGS14 Gene

Relevant External Links for RGS14

Genetic Association Database (GAD)
RGS14
Human Genome Epidemiology (HuGE) Navigator
RGS14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS14

No disorders were found for RGS14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS14 Gene

Publications for RGS14 Gene

  1. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PMID: 17635935) Cho H. … Kehrl J.H. (J. Cell Biol. 2007) 3 4 23 67
  2. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. (PMID: 19878719) Shu F.J. … Hepler J.R. (Cell. Signal. 2010) 3 23
  3. Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. (PMID: 12534294) Hollinger S. … Hepler J.R. (Biochemistry 2003) 3 23
  4. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. (PMID: 11976690) Kimple R.J. … Siderovski D.P. (Nature 2002) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RGS14 Gene

Sources for RGS14 Gene

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