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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGS14 Gene

protein-coding GIFtS: 61
GCID: GC05P176784

regulator of G-protein signaling 14

(Previous name: regulator of G-protein signalling 14 )

Explore 7 diseases affiliated with
RGS14 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 14¹ ²
Regulator Of G-Protein Signalling 14¹ ²

External Ids:	HGNC: 9996¹	Entrez Gene: 10636²	Ensembl: ENSG00000169220⁷	OMIM: 602513⁵	UniProtKB: O43566³

Export aliases for RGS14 gene to outside databases

Previous GC identifers: GC05P177158 GC05P177627 GC05P176720 GC05P176765 GC05P176717 GC05P171705

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS14:

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two

Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of

G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting

as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis

allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers,

thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not

been thoroughly characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RGS14_HUMAN, O43566

Function: Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and

hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha

subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i)

alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on

G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and

Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2

phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1.

Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent

mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite

outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory

Gene Wiki entry for RGS14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGS14 gene promoter:
RFX1 AML1a RREB-1 STAT5A Nkx2-5 Ik-3 LCR-F1 RORalpha2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS14 promoter sequence

Search SABiosciences Chromatin IP Primers for RGS14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3

RGS14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS14 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P176784: view genomic region (about GC identifiers)

Start:	176,784,838 bp from pter	End:	176,799,602 bp from pter
Size:	14,765 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGS14_HUMAN, O43566 (See protein sequence)

Recommended Name: Regulator of G-protein signaling 14

Size: 566 amino acids; 61447 Da

Subunit: Interacts with GNAO1 and GNAI2. Interacts (via RGS and GoLoco domains) GNAI1; the interaction occurs in the

centrosomes. Interacts with RABGEF1; the interactions is GTP-dependent. Interacts with RAP2A; the interactions is

GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI. Associates with

microtubules. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts with RIC8A (via

C-terminus). Interacts (via RBD 1 domain) with HRAS1 (active GTP-bound form preferentially). Interacts (via RBD

domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1. Interacts

(via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF.

Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active

GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially). Interacts with GNAI1 (via active GTP-

or inactive GDP-bound forms); the interaction prevents association of RGS14 with centrosomes or nuclear localization.

Interacts with GNAI2. Interacts with GNAI3 (via active GTP- or inactive GDP-bound forms); the interaction prevents

association of RGS14 with centrosomes or nuclear localization (By similarity). Associates with microtubules

Subcellular location: Nucleus (By similarity). Nucleus, PML body (By similarity). Cytoplasm. Membrane (By similarity).

Cell membrane (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle.

Cytoplasm, cytoskeleton, spindle pole (By similarity). Cell projection, dendrite (By similarity). Cell projection,

dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By

similarity). Note=Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to

segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the

nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing

center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during

mitosis. Relocalizes to the nucleus in PML nuclear bodies in response to heat stress. Colocalizes with RIC8A in CA2

hippocampal neurons. Localizes to spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a

CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha

subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS1. Colocalizes

with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm

and membranes (By similarity)

Sequence caution: Sequence=AAB92614.1; Type=Frameshift; Positions=337, 344, 348, 539, 544;

5 PDB 3D structures from and Proteopedia for RGS14:

2JNU (3D)

2OM2 (3D)

2XNS (3D)

3ONW (3D)

3QI2 (3D)

Secondary accessions: O43565 Q506M1 Q6ZWA4 Q8TD62

Alternative splicing: 4 isoforms: O43566-7 O43566-4 O43566-5 O43566-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RGS14: NX_O43566

Post-translational modifications:

Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i)

alpha subunit GNAI1 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43566

RGS14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006471.2

ENSEMBL proteins:

ENSP00000386229 ENSP00000422329

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RGS14 OriGene Protein Over-expression Lysate: RGS14 OriGene Custom Protein Services for RGS14
	GenScript Custom Purified and Recombinant Proteins Services for RGS14
	Novus Biologicals RGS14 Proteins Novus Biologicals RGS14 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RGS14
	Uscn Proteins for RGS14

Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	ISS	--
GO:0005634	nucleus	ISS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	ISS	--
GO:0005813	centrosome	ISS	--

RGS14 for ontologies About GeneDecksing

RGS14 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RGS14
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): RGS14 OriGene Custom Antibody Services for RGS14
	GenScript Custom Superior Antibodies Services for RGS14
	Novus Biologicals RGS14 Antibodies
	Abcam antibodies for RGS14
	Uscn Antibodies for RGS14
	ThermoFisher Antibodies for RGS14

Assay Products for RGS14:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RGS14
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RGS14

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGS14 for domains About GeneDecksing

5 InterPro domains/families:

IPR024066 Regulat_G_prot_signal_dom1

IPR003116 Raf-like_ras-bd

IPR003109 GoLoco_motif

IPR000342 Regulat_G_prot_signal

IPR016137 Regulat_G_prot_signal_superfam

Graphical View of Domain Structure for InterPro Entry O43566

ProtoNet protein and cluster: O43566

3 Blocks protein families:

IPB000342 Regulator of G-protein signalling (RGS) protein signature

IPB003109 G-alpha GTPase activator

IPB003116 Raf-like Ras-binding

UniProtKB/Swiss-Prot: RGS14_HUMAN, O43566

Domain: The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the

nucleus and centrosomes (By similarity)

Domain: The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus

and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3 (By similarity)

Domain: The RBD domains are necessary for localization to the nucleus and centrosomes (By similarity)

Similarity: Contains 1 GoLoco domain

Similarity: Contains 2 RBD (Ras-binding) domains

Similarity: Contains 1 RGS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: