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Aliases for RGS13 Gene

Aliases for RGS13 Gene

  • Regulator Of G-Protein Signaling 13 2 3 5
  • Regulator Of G-Protein Signalling 13 2

External Ids for RGS13 Gene

Previous GeneCards Identifiers for RGS13 Gene

  • GC01P190395
  • GC01P188119
  • GC01P189071
  • GC01P189893
  • GC01P189336
  • GC01P190871
  • GC01P163841

Summaries for RGS13 Gene

Entrez Gene Summary for RGS13 Gene

  • The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS13 Gene

RGS13 (Regulator Of G-Protein Signaling 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS13 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).

Gene Wiki entry for RGS13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS13 Gene

Genomics for RGS13 Gene

Regulatory Elements for RGS13 Gene

Enhancers for RGS13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGS13 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS13 Gene

Chromosome:
1
Start:
192,636,138 bp from pter
End:
192,660,311 bp from pter
Size:
24,174 bases
Orientation:
Plus strand

Genomic View for RGS13 Gene

Genes around RGS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS13 Gene

Proteins for RGS13 Gene

  • Protein details for RGS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14921-RGS13_HUMAN
    Recommended name:
    Regulator of G-protein signaling 13
    Protein Accession:
    O14921
    Secondary Accessions:
    • Q6PGR2
    • Q8TD63
    • Q9BX45

    Protein attributes for RGS13 Gene

    Size:
    159 amino acids
    Molecular mass:
    19135 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RGS13 Gene

Proteomics data for RGS13 Gene at MOPED

Post-translational modifications for RGS13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RGS13

No data available for DME Specific Peptides for RGS13 Gene

Domains & Families for RGS13 Gene

Gene Families for RGS13 Gene

Protein Domains for RGS13 Gene

Suggested Antigen Peptide Sequences for RGS13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14921

UniProtKB/Swiss-Prot:

RGS13_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS13: view

Function for RGS13 Gene

Molecular function for RGS13 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).

Gene Ontology (GO) - Molecular Function for RGS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RGS13: view
genes like me logo Genes that share phenotypes with RGS13: view

Animal Models for RGS13 Gene

MGI Knock Outs for RGS13:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS13

miRNA for RGS13 Gene

miRTarBase miRNAs that target RGS13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS13 Gene

Localization for RGS13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS13 Gene COMPARTMENTS Subcellular localization image for RGS13 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3
extracellular 2
golgi apparatus 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RGS13 Gene

Pathways & Interactions for RGS13 Gene

genes like me logo Genes that share pathways with RGS13: view

Pathways by source for RGS13 Gene

Gene Ontology (GO) - Biological Process for RGS13 Gene

None

No data available for SIGNOR curated interactions for RGS13 Gene

Drugs & Compounds for RGS13 Gene

No Compound Related Data Available

Transcripts for RGS13 Gene

Unigene Clusters for RGS13 Gene

Regulator of G-protein signaling 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for RGS13 Gene

GeneLoc Exon Structure for
RGS13
ECgene alternative splicing isoforms for
RGS13

Expression for RGS13 Gene

mRNA expression in normal human tissues for RGS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS13 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.7) and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for RGS13 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS13 Gene



SOURCE GeneReport for Unigene cluster for RGS13 Gene Hs.497220

genes like me logo Genes that share expression patterns with RGS13: view

Protein tissue co-expression partners for RGS13 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RGS13 Gene

Orthologs for RGS13 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS13 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RGS13 35
  • 92.62 (n)
  • 91.77 (a)
RGS13 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs13 35
  • 85.44 (n)
  • 83.54 (a)
Rgs13 16
Rgs13 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS13 35
  • 99.58 (n)
  • 100 (a)
RGS13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs13 35
  • 84.93 (n)
  • 83.44 (a)
cow
(Bos Taurus)
Mammalia RGS13 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS13 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS13 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS13 35
  • 66.88 (n)
  • 57.86 (a)
RGS13 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS13 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs13 35
  • 66.67 (n)
  • 60.4 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs13 36
  • 40 (a)
ManyToMany
si:ch211-117l17.5 36
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5036 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-1 36
  • 25 (a)
ManyToMany
rgs-2 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for RGS13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS13 Gene

ENSEMBL:
Gene Tree for RGS13 (if available)
TreeFam:
Gene Tree for RGS13 (if available)

Paralogs for RGS13 Gene

Paralogs for RGS13 Gene

(19) SIMAP similar genes for RGS13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS13: view

Variants for RGS13 Gene

Sequence variations from dbSNP and Humsavar for RGS13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16834603 - 192,659,493(+) CTTTT(C/G)AAAAC reference, missense
rs2146608 -- 192,657,342(+) TTGGT(C/T)CTCCC intron-variant
rs2296020 -- 192,657,696(+) TGATT(A/G)GACAT intron-variant
rs2296021 -- 192,657,726(+) TACAA(A/C)CTAAT intron-variant
rs2296022 -- 192,657,994(+) CATCA(C/T)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS13 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990
nsv467005 CNV Gain 19166990
esv2283787 CNV Deletion 18987734
esv2720762 CNV Deletion 23290073
esv2720773 CNV Deletion 23290073
esv991606 CNV Deletion 20482838
esv1739511 CNV Deletion 17803354
esv2720784 CNV Deletion 23290073
esv2720795 CNV Deletion 23290073
esv2720807 CNV Deletion 23290073

Variation tolerance for RGS13 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RGS13 Gene

Disorders for RGS13 Gene

Relevant External Links for RGS13

Genetic Association Database (GAD)
RGS13
Human Genome Epidemiology (HuGE) Navigator
RGS13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS13

No disorders were found for RGS13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS13 Gene

Publications for RGS13 Gene

  1. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J. … Wu X. (Carcinogenesis 2010) 3 48 67
  2. Functional characterization of the G protein regulator RGS13. (PMID: 11875076) Johnson E.N. … Druey K.M. (J. Biol. Chem. 2002) 2 3
  3. p53 negatively regulates RGS13 protein expression in immune cells. (PMID: 21531726) Iwaki S. … Druey K.M. (J. Biol. Chem. 2011) 3
  4. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3
  5. Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation. (PMID: 20974683) Xie Z. … Druey K.M. (J Mol Cell Biol 2010) 3

Products for RGS13 Gene

Sources for RGS13 Gene

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