Aliases for RGS13 Gene
External Ids for RGS13 Gene
Previous GeneCards Identifiers for RGS13 Gene
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS13 Gene
RGS13 (Regulator Of G-Protein Signaling 13) is a Protein Coding gene. Diseases associated with RGS13 include mantle cell lymphoma. Among its related pathways are Activation of cAMP-Dependent PKA and G-AlphaQ Signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS18.
UniProtKB/Swiss-Prot for RGS13 Gene
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).