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RGS13 Gene

protein-coding   GIFtS: 52
GCID: GC01P192605

Regulator Of G-Protein Signaling 13

(Previous name: regulator of G-protein signalling 13)
  See RGS13-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 131 2
Regulator Of G-Protein Signalling 131 2

External Ids:    HGNC: 99951   Entrez Gene: 60032   Ensembl: ENSG000001270747   OMIM: 6071905   UniProtKB: O149213   

Export aliases for RGS13 gene to outside databases

Previous GC identifers: GC01P190395 GC01P188119 GC01P189071 GC01P189893 GC01P189336 GC01P190871 GC01P163841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS13 Gene:
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family
members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic
conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G
protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have
been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor
activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same
isoform exist. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS13 Gene:
RGS13 (regulator of G-protein signaling 13) is a protein-coding gene. Diseases associated with RGS13 include mantle cell lymphoma. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS13_HUMAN, O14921
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity)

Gene Wiki entry for RGS13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS13 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   STAT1   oct-B3   oct-B2   POU2F2   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS13 promoter sequence
   Search Chromatin IP Primers for RGS13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.2   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31.2

RGS13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS13 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P192605:  view genomic region     (about GC identifiers)

Start:
192,605,268 bp from pter      End:
192,629,441 bp from pter
Size:
24,174 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGS13_HUMAN, O14921 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 13  
Size: 159 amino acids; 19135 Da
Secondary accessions: Q6PGR2 Q8TD63 Q9BX45

Explore the universe of human proteins at neXtProt for RGS13: NX_O14921

Explore proteomics data for RGS13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002918.1  NP_658912.1  

    ENSEMBL proteins: 
     ENSP00000375853   ENSP00000442837  

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    antibodies-online proteins for RGS13 (6 products) 

     
    antibodies-online peptides for RGS13

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry O14921

    ProtoNet protein and cluster: O14921

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS13_HUMAN, O14921
    Similarity: Contains 1 RGS domain


    Find genes that share domains with RGS13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS13_HUMAN, O14921
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RGS13           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rgs13):
     hematopoietic system  immune system 

    Find genes that share phenotypes with RGS13           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgs13tm1Drue for RGS13

       genOway: Develop your customized and physiologically relevant rodent model for RGS13

    miRNA
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    miRTarBase miRNAs that target RGS13:
    hsa-mir-146a-5p (MIRT021238), hsa-mir-335-5p (MIRT018349)

    Block miRNA regulation of human, mouse, rat RGS13 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate RGS13:
    hsa-miR-130a* hsa-miR-23c hsa-miR-4282 hsa-miR-373* hsa-miR-369-3p hsa-miR-23b hsa-miR-23a hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidRGS13 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    extracellular2
    nucleus2
    cytoskeleton1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IBA--

    Find genes that share ontologies with RGS13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS13 About    
    See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Activation of cAMP-Dependent PKA
    cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS13
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS13
    Interactions:

        Search GeneGlobe Interaction Network for RGS13

    5 Interacting proteins for RGS13 (O149213) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483I2D: score=2 
    CREB1P162203I2D: score=1 
    PRKACAP176123I2D: score=1 
    TOMM70AO948263I2D: score=1 
    UBCP0CG483I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity IBA--
    GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway ----

    Find genes that share ontologies with RGS13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for RGS13



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGS13 gene (2 alternative transcripts): 
    NM_002927.4  NM_144766.2  

    Unigene Cluster for RGS13:

    Regulator of G-protein signaling 13
    Hs.497220  [show with all ESTs]
    Unigene Representative Sequence: NM_002927
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391995(uc001gsj.3) ENST00000462955(uc001gsk.3) ENST00000482095
    ENST00000543215
    miRNA
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    hsa-miR-130a* hsa-miR-23c hsa-miR-4282 hsa-miR-373* hsa-miR-369-3p hsa-miR-23b hsa-miR-23a hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidRGS13 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS13
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      QuantiTect SYBR Green Assays in human, mouse, rat RGS13
      QuantiFast Probe-based Assays in human, mouse, rat RGS13

    Additional mRNA sequence: 

    AF030107.1 AF493935.1 AY562947.1 BC016667.1 BC056866.1 BT006929.1 CR536532.1 

    5 DOTS entries:

    DT.95156799  DT.109775  DT.99982173  DT.121383710  DT.100749971 

    Selected AceView cDNA sequences (see all 38):

    AA728997 CR536532 BM454211 CR610389 BC016667 AI862711 AA714861 NM_002927 
    AY562947 NM_144766 CR599001 AL583136 AL582920 BG685271 BT006929 CB985475 
    BU943419 AW054946 AF493935 BM455396 AL583135 CB143137 BG177015 BC036950 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RGS13    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                          
    SP2:        -                                 


    ECgene alternative splicing isoforms for RGS13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAACATTT
    RGS13 Expression
    About this image


    RGS13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Tonsil (Hematopoietic System)
    RGS13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497220
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGS13 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs131 , 5 regulator of G-protein signaling 131, 5 85.44(n)1
    83.54(a)1
      1 (62.56 cM)5
    2467091  NM_153171.41  NP_694811.11 
     1441386675 
    chicken
    (Gallus gallus)
    Aves RGS131 regulator of G-protein signaling 13 66.88(n)
    57.86(a)
      429059  XM_004943138.1  XP_004943195.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGS136
    regulator of G-protein signaling 13
    54(a)
    1 ↔ 1
    GL343267.1(1487696-1499034)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rgs131 regulator of G-protein signaling 13 66.67(n)
    60.4(a)
      100486196  XM_002939079.2  XP_002939125.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-117l17.56
    rgs136
    regulator of G-protein signaling 13
    42(a)
    40(a)
    many ↔ many
    many ↔ many
    22(23536901-23543787) ENSDARG00000007265
    2(6179990-6186663) ENSDARG00000017653
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50366
    --
    23(a)
    1 → many
    2R(13680387-13685633)
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-26
    rgs-16
    Protein RGS-1, isoform b
    31(a)
    25(a)
    many ↔ many
    many ↔ many
    X(12712653-12728389) WBGene00004345
    III(10014593-10016534) WBGene00004344


    ENSEMBL Gene Tree for RGS13 (if available)
    TreeFam Gene Tree for RGS13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS13 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS162  RGS172  
    RGS52  RGS12  RGS182  RGS42  
    Selected SIMAP similar genes for RGS13 using alignment to 1 protein entry:     RGS13_HUMAN(see all similar genes):
    RGS4    RGS1    RGS21    RGS8    RGS3    RGS18
    RGS5    RGS17    RGS2    RGS20    RGS16    RGS7
    RGS10    RGS11    RGS9    RGS19    RGS6    RGS12

    Find genes that share paralogs with RGS13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS13 (see all 581)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483716871,2
    C--192603269(+) AGGAC-/AGACCT 2 -- us2k10--------
    rs37956191,2
    C,F--192603399(-) ACTCTT/CGGACA 2 -- us2k11Minor allele frequency- C:0.01EA 1486
    rs1165571561,2
    C,F--192603530(+) ATTAAC/TCAGTA 2 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1866781121,2
    --192603536(+) CAGTAA/GTTATA 2 -- us2k10--------
    rs37956181,2
    C,H--192603657(-) AAAATA/CTTTAA 2 -- us2k1 tfbs39Minor allele frequency- C:0.18NA WA CSA EA 369
    rs120439661,2
    C,F--192603676(+) CACATT/GTGAAC 2 -- us2k12Minor allele frequency- G:0.09WA EA 238
    rs120465071,2
    C,F--192603684(+) AACTTG/CTGTTA 2 -- us2k12Minor allele frequency- C:0.09WA EA 238
    rs37956171,2
    C,F,A,H--192603690(-) CCAAAG/ATAACA 2 -- us2k122Minor allele frequency- A:0.36NS EA NA WA CSA 2350
    rs359923161,2
    C--192603768(+) ACAGC-/CTTTCA 2 -- us2k12Minor allele frequency- C:0.25NA 4
    rs120255831,2
    C,F,H--192603798(+) AGCTGC/TACCAA 2 -- us2k115Minor allele frequency- T:0.07NS EA NA WA 1936

    HapMap Linkage Disequilibrium report for RGS13 (192605268 - 192629441 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RGS13:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv991606CNV Deletion20482838
    esv2720762CNV Deletion23290073
    esv2720807CNV Deletion23290073
    esv2720784CNV Deletion23290073
    esv1739511CNV Deletion17803354
    esv2720795CNV Deletion23290073
    esv2283787CNV Deletion18987734
    esv2720773CNV Deletion23290073
    nsv466994CNV Loss19166990
    nsv467005CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607190    OMIM disorders: --

    1 disease for RGS13:    
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    mantle cell lymphoma


    Find genes that share disorders with RGS13           About GenesLikeMe

    Genetic Association Database (GAD): RGS13
    Human Genome Epidemiology (HuGE) Navigator: RGS13 (4 documents)

    Export disorders for RGS13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS13 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with RGS13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (Carcinogenesis 2010)
    2. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Functional characterization of the G protein regulator RGS13. (PubMed id 11875076)1, 3 Johnson E.N. and Druey K.M. (J. Biol. Chem. 2002)
    6. p53 negatively regulates RGS13 protein expression in immune cells. (PubMed id 21531726)1 Iwaki S....Druey K.M. (J. Biol. Chem. 2011)
    7. Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation. (PubMed id 20974683)1 Xie Z....Druey K.M. (J Mol Cell Biol 2010)
    8. RGS13 controls g protein-coupled receptor-evoked responses of human mast cells. (PubMed id 19017978)1 Bansal G....Druey K.M. (J. Immunol. 2008)
    9. RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. (PubMed id 16565322)1 Han J.I....Kehrl J.H. (J. Leukoc. Biol. 2006)
    10. High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. (PubMed id 12970790)1 Islam T.C....Sander B. (Leukemia 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6003 HGNC: 9995 AceView: RGS13 Ensembl:ENSG00000127074 euGenes: HUgn6003
    ECgene: RGS13 H-InvDB: RGS13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGS13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS13 gene:
    Search GeneIP for patents involving RGS13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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