Aliases for RGS12 Gene
External Ids for RGS12 Gene
Previous GeneCards Identifiers for RGS12 Gene
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS12 Gene
RGS12 (Regulator Of G-Protein Signaling 12) is a Protein Coding gene. Diseases associated with RGS12 include Bone Giant Cell Tumor. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase activator activity and GTPase regulator activity. An important paralog of this gene is RGS14.
UniProtKB/Swiss-Prot for RGS12 Gene
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.
Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.