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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS12 Gene

protein-coding   GIFtS: 62
GCID: GC04P003294

Regulator Of G-Protein Signaling 12

(Previous name: regulator of G-protein signalling 12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Regulator Of G-Protein Signaling 121 2
Regulator Of G-Protein Signalling 121 2

External Ids:    HGNC: 99941   Entrez Gene: 60022   Ensembl: ENSG000001597887   OMIM: 6025125   UniProtKB: O149243   
ORGUL members:    fRNAdb10:FR237606      
H-InvDB12:HIT000066880    
NCBI13:AF086001    
NONCODE14:n332878 n339810      
RNAdb15:HIV1464    

Export aliases for RGS12 gene to outside databases

Previous GC identifers: GC04P003321 GC04P003349 GC04P003348 GC04P003352 GC04P003253


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS12 Gene:
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may
function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This
protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been
identified for this gene. Other alternative splice variants have been described but their biological nature has
not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS12 Gene: 
RGS12 (regulator of G-protein signaling 12) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RGS12 include bone giant cell tumor, and giant cell tumor, and among its related super-pathways are G-AlphaQ Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase regulator activity and GTPase activator activity. An important paralog of this gene is RGS14.

UniProtKB/Swiss-Prot: RGS12_HUMAN, O14924
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form

Gene Wiki entry for RGS12 Gene

fRNAdb sequence ontology for RGS12:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for RGS12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS12 gene promoter:
         Max1   ER-alpha   AML1a   p53   RelA   Evi-1   AREB6   S8   Zic3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGS12 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

RGS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS12 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003294:  view genomic region     (about GC identifiers)

Start:
3,294,755 bp from pter      End:
3,441,640 bp from pter
Size:
146,886 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RGS12

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGS12_HUMAN, O14924 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 12  
Size: 1447 amino acids; 156357 Da
Subunit: Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent (By similarity)
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for RGS12:
2EBZ (3D)        2KV8 (3D)    
Secondary accessions: B1AQ30 B1AQ31 B1AQ32 O14922 O14923 O43510 O75338
Alternative splicing: 4 isoforms:  O14924-1   O14924-2   O14924-3   O14924-4   

Explore the universe of human proteins at neXtProt for RGS12: NX_O14924

Explore proteomics data for RGS12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14924

  • RGS12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGS12 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002917.1  NP_937870.1  NP_937872.1  

    ENSEMBL proteins: 
     ENSP00000339381   ENSP00000424251   ENSP00000372238   ENSP00000342133   ENSP00000338509  
     ENSP00000440566   ENSP00000304459   ENSP00000438888  

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    Cloud-Clone Corp. Proteins for RGS12 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000794condensed nuclear chromosome TAS10869340
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--
    GO:0016363nuclear matrix IEA--

    RGS12 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RGS: Regulators of G-protein signaling

    5/8 InterPro protein domains (see all 8):
     IPR024066 Regulat_G_prot_signal_dom1
     IPR003116 Raf-like_ras-bd
     IPR003109 GoLoco_motif
     IPR011993 PH_like_dom
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry O14924

    ProtoNet protein and cluster: O14924

    5 Blocks protein domains:
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB003109 G-alpha GTPase activator
    IPB003116 Raf-like Ras-binding
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: RGS12_HUMAN, O14924
    Domain: The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3 (By similarity)
    Similarity: Contains 1 GoLoco domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PID domain
    Similarity: Contains 2 RBD (Ras-binding) domains
    Similarity: Contains 1 RGS domain


    RGS12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS12_HUMAN, O14924
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form

         Genatlas biochemistry entry for RGS12:
    negative regulator of G protein signaling 12,functioning as GTPase-activating protein for G protein alpha i and q
    subunits,with four alternatively spliced isoforms,highly expressed in brain,kidney,thymus,prostate,C elegans
    EGL-10 and yeast SST2 homolog

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0030695GTPase regulator activity IDA9651375
         
    RGS12 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RGS12:
     Decreased cilium length after   Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rgs12):
     hematopoietic system  immune system  normal  skeleton 

    RGS12 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rgs12tm1Lex for RGS12

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGS12 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGS12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Activation of cAMP-Dependent PKA
    cAMP Pathway0.77

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS12
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/28 Interacting proteins for RGS12 (O149242, 3 ENSP000003393814) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB3P051062, 3MINT-45916 I2D: score=2 
    ITGB1P055562, 3MINT-45935 I2D: score=1 
    ITGB7P260102, 3MINT-45915 I2D: score=1 
    BCRP112742, 3, ENSP000003035074MINT-69542 I2D: score=1 STRING: ENSP00000303507
    HRASP011123, ENSP000003098454I2D: score=4 STRING: ENSP00000309845
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007165signal transduction ----
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS9651375
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS9651375

    RGS12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS12

    Search CenterWatch for drugs/clinical trials and news about RGS12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for RGS12 gene (7 alternative transcripts): 
    NM_002926.3  NM_198227.1  NM_198229.2  NM_198230.1  NM_198430.1  NM_198432.1  NM_198587.1  

    Unigene Cluster for RGS12:

    Regulator of G-protein signaling 12
    Hs.527061  [show with all ESTs]
    Unigene Representative Sequence: NM_002926
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000506631(uc010ics.1) ENST00000344733(uc003ggw.3 uc003ggy.1)
    ENST00000502947(uc003ggx.1) ENST00000514268(uc011bvr.1) ENST00000382788(uc011bvs.2)
    ENST00000511805 ENST00000513784 ENST00000338806(uc003ggz.3) ENST00000506998(uc010ict.1)
    ENST00000508158(uc010icu.1) ENST00000505570 ENST00000512990 ENST00000503041
    ENST00000504194(uc003gha.3 uc010icv.3) ENST00000512266 ENST00000513991(uc003ghb.2)
    ENST00000515521 ENST00000510803
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF030109.1 AF030110.1 AF030111.1 AF035152.1 AF464735.1 AF464736.1 AF464737.1 AK123325.1 
    AK290805.1 AK293767.1 AK301510.1 AK303135.1 AK308734.1 AK310999.1 AY987042.1 BC012118.1 
    BC028154.1 BC106944.1 BC118594.1 

    22 DOTS entries:

    DT.100795518  DT.100795519  DT.92429869  DT.455298  DT.101983738  DT.40132607  DT.101983740  DT.116803 
    DT.95274682  DT.99974025  DT.100795513  DT.92429866  DT.100721399  DT.95312695  DT.92054661  DT.116804 
    DT.121269468  DT.121269477  DT.40225421  DT.95362660  DT.100801601  DT.91898055 

    24/278 AceView cDNA sequences (see all 278):

    AI820007 AL134672 BX483942 BM932171 BF001988 AI492460 BE890033 AI700519 
    BE302699 BM931256 BC028154 BF591183 AW301119 AW593240 BC012118 CR614898 
    AI089936 AI298195 AW452367 AA974676 CA448454 CB529269 W67276 AF464737 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RGS12 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:                                            -     -     -                             -                                               -           -         
    SP2:                                            -     -     -                             -                                               -           -         
    SP3:                                                                                      -                                               -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for RGS12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS12 expression in normal human tissues (normalized intensities)      RGS12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCCCTG
    RGS12 Expression
    About this image


    RGS12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Epithelium (Uncategorized)
             gingival epithelium   
     
     Oral Cavity (Gastrointestinal Tract)
             gingival epithelium   

    See RGS12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS12

    SOURCE GeneReport for Unigene cluster: Hs.527061

    UniProtKB/Swiss-Prot: RGS12_HUMAN, O14924
    Tissue specificity: Isoform 3 is brain specific

        SABiosciences Expression via Pathway-Focused PCR Array including RGS12: 
              Leukemia in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGS12 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs121 , 5 regulator of G-protein signaling 121, 5 83(n)1
    86.83(a)1
      5 (17.96 cM)5
    717291  NM_173402.21  NP_775578.21 
     349494455 
    chicken
    (Gallus gallus)
    Aves RGS121 regulator of G-protein signaling 12 69.78(n)
    73.73(a)
      395619  XM_420820.3  XP_420820.3 
    lizard
    (Anolis carolinensis)
    Reptilia RGS126
    regulator of G-protein signaling 12
    67(a)
    1 ↔ 1
    GL343236.1(2113285-2232050)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480597302   -- 75.65(n)    48059730 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.186942 Danio rerio RGS12TS-S mRNA, complete cds, alternatively more 75.13(n)    AY427669.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta loco6
    locomotion defects
    22(a)
    1 → many
    3R(18445690-18465082)
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-46
    Protein RGS-4, isoform a
    24(a)
    possible ortholog
    II(12667698-12671623)


    ENSEMBL Gene Tree for RGS12 (if available)
    TreeFam Gene Tree for RGS12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS12 gene
    RGS142  RGS112  RGS102  RGS72  RGS62  RGS92  
    12 SIMAP similar genes for RGS12 using alignment to 9 protein entries:     RGS12_HUMAN (see all proteins):
    DKFZp761K1617    RGS10    RGS4    RGS17    RGS3    RGS14
    RGS5    RGS16    RGS19    RGS1    RGS13    RGS8

    RGS12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2928 SNPs in RGS12 are shown (see all 2928)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs74356011,2
    C,F,H--3307221(+) GGGCTC/TTGCGA 1 -- us2k128Minor allele frequency- T:0.24NS EA NA WA CSA 2776
    rs1433088091,2
    --3307225(+) TTTGCA/GAATAA 1 -- us2k10--------
    rs1143304131,2
    C,F--3307274(+) GTCCTC/TGATGG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1421395321,2
    --3313893(+) TTCAGC/TTGGAA 2 -- us2k10--------
    rs1897345891,2
    --3313968(+) AGTTTA/TAAAAA 2 -- us2k10--------
    rs1929414151,2
    C--3313998(+) ACTTAC/TGTGAT 2 -- us2k10--------
    rs1497233121,2
    --3313999(+) CTTATA/GTGATT 2 -- us2k10--------
    rs1840486081,2
    --3314007(+) ATTATA/TTTGGG 2 -- us2k10--------
    rs2011272401,2
    --3314114(+) AGGTT-/CACTGG 2 -- us2k10--------
    rs800129751,2
    C,F--3314148(+) CCCACG/ATGGTG 2 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for RGS12 (3294755 - 3441640 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/39 variations for RGS12 (see all 39):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726881CNV Deletion23290073
    esv1534592CNV Deletion17803354
    esv2726882CNV Deletion23290073
    esv2726880CNV Deletion23290073
    esv2726879CNV Deletion23290073
    esv2328657CNV Deletion18987734
    esv2726877CNV Deletion23290073
    esv2726878CNV Deletion23290073
    esv3639CNV Deletion18987735
    esv2677000CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602512OMIM information: 601519 603663 605480 609456    
    6 diseases for RGS12:    About MalaCards
    bone giant cell tumor    giant cell tumor    schizophrenia    squamous cell carcinoma
    prostatitis    leukemia


    RGS12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS12
    Human Genome Epidemiology (HuGE) Navigator: RGS12 (4 documents)

    Export disorders for RGS12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS12 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with RGS12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. (PubMed id 9651375)1, 2, 3, 9 Snow B.E....Siderovski D.P. (1998)
    2. Novel alternative splicing and nuclear localization of human RGS12 gene products. (PubMed id 10869340)1, 2, 9 Chatterjee T.K. and Fisher R.A. (2000)
    3. Genetic variations in regulator of G-protein signalin g genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (2010)
    4. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    5. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    6. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    7. Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. (PubMed id 11130074)1, 9 Schiff M.L....Diverse-Pierluissi M. (2000)
    8. Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. (PubMed id 18617639)4 Litonjua A.A....Weiss S.T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6002 HGNC: 9994 AceView: RGS12 Ensembl:ENSG00000159788 euGenes: HUgn6002
    ECgene: RGS12 H-InvDB: RGS12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGS12 gene:
    Search GeneIP for patents involving RGS12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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