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Aliases for RGS12 Gene

Aliases for RGS12 Gene

  • Regulator Of G-Protein Signaling 12 2 3
  • Regulator Of G-Protein Signalling 12 2

External Ids for RGS12 Gene

Previous GeneCards Identifiers for RGS12 Gene

  • GC04P003321
  • GC04P003349
  • GC04P003348
  • GC04P003352
  • GC04P003294

Summaries for RGS12 Gene

Entrez Gene Summary for RGS12 Gene

  • This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS12 Gene

RGS12 (Regulator Of G-Protein Signaling 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase activator activity and GTPase regulator activity. An important paralog of this gene is RGS10.

UniProtKB/Swiss-Prot for RGS12 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form

  • Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis

Gene Wiki entry for RGS12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS12 Gene

Genomics for RGS12 Gene

Regulatory Elements for RGS12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGS12 Gene

3,292,978 bp from pter
3,439,913 bp from pter
146,936 bases
Plus strand

Genomic View for RGS12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS12 Gene

Proteins for RGS12 Gene

  • Protein details for RGS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 12
    Protein Accession:
    Secondary Accessions:
    • B1AQ30
    • B1AQ31
    • B1AQ32
    • B7Z764
    • E7EMN9
    • O14922
    • O14923
    • O43510
    • O75338
    • Q147X0
    • Q8WX95

    Protein attributes for RGS12 Gene

    1447 amino acids
    Molecular mass:
    156357 Da
    Quaternary structure:
    • Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.

    Three dimensional structures from OCA and Proteopedia for RGS12 Gene

    Alternative splice isoforms for RGS12 Gene

neXtProt entry for RGS12 Gene

Proteomics data for RGS12 Gene at MOPED

Post-translational modifications for RGS12 Gene

  • Ubiquitination at Lys1115
  • Modification sites at PhosphoSitePlus

Other Protein References for RGS12 Gene

No data available for DME Specific Peptides for RGS12 Gene

Domains for RGS12 Gene

Gene Families for RGS12 Gene

  • RGS :Regulators of G-protein signaling

Graphical View of Domain Structure for InterPro Entry



  • O14924
  • The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.
  • Contains 1 GoLoco domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PID domain.
  • Contains 2 RBD (Ras-binding) domains.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS12: view

Function for RGS12 Gene

Molecular function for RGS12 Gene

GENATLAS Biochemistry: negative regulator of G protein signaling 12,functioning as GTPase-activating protein for G protein alpha i and q subunits,with four alternatively spliced isoforms,highly expressed in brain,kidney,thymus,prostate,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
UniProtKB/Swiss-Prot Function: Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis

Gene Ontology (GO) - Molecular Function for RGS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding --
GO:0030695 GTPase regulator activity IDA 9651375
genes like me logo Genes that share ontologies with RGS12: view
genes like me logo Genes that share phenotypes with RGS12: view

Animal Model Products

CRISPR Products

miRNA for RGS12 Gene

miRTarBase miRNAs that target RGS12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RGS12 Gene

Localization for RGS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS12 Gene

Isoform 5: Nucleus matrix. Note=Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains.

Subcellular locations from

Jensen Localization Image for RGS12 Gene COMPARTMENTS Subcellular localization image for RGS12 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RGS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome TAS 10869340
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS12: view

Pathways for RGS12 Gene

genes like me logo Genes that share pathways with RGS12: view

Pathways by source for RGS12 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RGS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007165 signal transduction --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9651375
GO:0035556 intracellular signal transduction IEA --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with RGS12: view

Transcripts for RGS12 Gene

Unigene Clusters for RGS12 Gene

Regulator of G-protein signaling 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RGS12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS12 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP6: - - -
SP7: -
SP8: - -
SP10: -

ExUns: 20a · 20b ^ 21

Relevant External Links for RGS12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS12 Gene

mRNA expression in normal human tissues for RGS12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGS12 Gene

SOURCE GeneReport for Unigene cluster for RGS12 Gene Hs.527061

mRNA Expression by UniProt/SwissProt for RGS12 Gene

Tissue specificity: Isoform 3 is brain specific
genes like me logo Genes that share expressions with RGS12: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RGS12 Gene

Orthologs for RGS12 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS12 35
  • 99.12 (n)
  • 99.17 (a)
RGS12 36
  • 99 (a)
(Bos Taurus)
Mammalia RGS12 35
  • 82.97 (n)
  • 81.78 (a)
RGS12 36
  • 84 (a)
(Canis familiaris)
Mammalia RGS12 35
  • 84.45 (n)
  • 84.69 (a)
RGS12 36
  • 84 (a)
(Mus musculus)
Mammalia Rgs12 35
  • 82.47 (n)
  • 85.99 (a)
Rgs12 16
Rgs12 36
  • 85 (a)
(Monodelphis domestica)
Mammalia RGS12 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia RGS12 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Rgs12 35
  • 81.9 (n)
  • 85.35 (a)
(Gallus gallus)
Aves RGS12 35
  • 69.85 (n)
  • 73.87 (a)
RGS12 36
  • 75 (a)
(Anolis carolinensis)
Reptilia RGS12 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731678 35
  • 64.9 (n)
  • 66.24 (a)
Str.6746 35
(Danio rerio)
Actinopterygii Dr.18694 35
rgs12a 36
  • 45 (a)
rgs12b 35
  • 63.18 (n)
  • 63.98 (a)
rgs12b 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta loco 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea rgs-7 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5555 36
  • 21 (a)
Species with no ortholog for RGS12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS12 Gene

Gene Tree for RGS12 (if available)
Gene Tree for RGS12 (if available)

Paralogs for RGS12 Gene

Paralogs for RGS12 Gene

genes like me logo Genes that share paralogs with RGS12: view

Variants for RGS12 Gene

Sequence variations from dbSNP and Humsavar for RGS12 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs743699 -- 3,303,389(+) AGGGC(A/G)CCTGC intron-variant
rs743714 -- 3,418,259(-) CCACC(C/T)GCCAA intron-variant
rs762860 -- 3,375,010(+) TTCGC(C/T)ATGCA intron-variant
rs762863 -- 3,414,967(+) GCGTG(A/T)GAGGG intron-variant
rs762864 -- 3,417,950(+) CCCCA(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS12 Gene

Variant ID Type Subtype PubMed ID
nsv878455 CNV Loss 21882294
nsv878456 CNV Loss 21882294
nsv878461 CNV Loss 21882294
nsv461165 CNV Loss 19166990
nsv878462 CNV Loss 21882294
esv2677000 CNV Deletion 23128226
esv24279 CNV Gain 19812545
esv2677976 CNV Deletion 23128226
nsv878463 CNV Loss 21882294
esv2726877 CNV Deletion 23290073
esv2726878 CNV Deletion 23290073
nsv4201 CNV Insertion 18451855
nsv428435 CNV Gain 18775914
esv2726879 CNV Deletion 23290073
esv2328657 CNV Deletion 18987734
esv2726880 CNV Deletion 23290073
nsv290570 CNV Loss 16902084
essv879 CNV CNV 17122850
dgv1566e1 CNV Complex 17122850
dgv637n27 CNV Loss 19166990
nsv878464 CNV Loss 21882294
dgv5429n71 CNV Loss 21882294
esv992281 CNV Insertion 20482838
esv1688529 CNV Insertion 17803354
dgv5430n71 CNV Loss 21882294
dgv5431n71 CNV Loss 21882294
nsv878471 CNV Loss 21882294
esv2726881 CNV Deletion 23290073
esv3639 CNV Deletion 18987735
esv2726882 CNV Deletion 23290073
dgv5432n71 CNV Loss 21882294
esv28164 CNV Gain 19812545
esv1534592 CNV Deletion 17803354
nsv461169 CNV Loss 19166990
nsv470004 CNV Loss 18288195
nsv818208 CNV Loss 17921354
nsv516505 CNV Loss 19592680
nsv10424 CNV Gain 18304495
nsv4202 CNV Loss 18451855

Relevant External Links for RGS12 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS12 Gene

Disorders for RGS12 Gene

Relevant External Links for RGS12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RGS12: view

No data available for UniProtKB/Swiss-Prot for RGS12 Gene

Publications for RGS12 Gene

  1. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. (PMID: 9651375) Snow B.E. … Siderovski D.P. (J. Biol. Chem. 1998) 2 3 4 23
  2. Novel alternative splicing and nuclear localization of human RGS12 gene products. (PMID: 10869340) Chatterjee T.K. … Fisher R.A. (J. Biol. Chem. 2000) 3 4 23
  3. Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. (PMID: 11130074) Schiff M.L. … DiversAc-Pierluissi M. (Nature 2000) 3 23
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48

Products for RGS12 Gene

Sources for RGS12 Gene

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