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RGS12 Gene

protein-coding   GIFtS: 64
GCID: GC04P003294

Regulator Of G-Protein Signaling 12

(Previous name: regulator of G-protein signalling 12)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 121 2
Regulator Of G-Protein Signalling 121 2

External Ids:    HGNC: 99941   Entrez Gene: 60022   Ensembl: ENSG000001597887   OMIM: 6025125   UniProtKB: O149243   

Export aliases for RGS12 gene to outside databases

Previous GC identifers: GC04P003321 GC04P003349 GC04P003348 GC04P003352 GC04P003253


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS12 Gene:
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may
function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This
protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been
identified for this gene. Other alternative splice variants have been described but their biological nature has
not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS12 Gene:
RGS12 (regulator of G-protein signaling 12) is a protein-coding gene. GO annotations related to this gene include GTPase regulator activity and GTPase activator activity. An important paralog of this gene is RGS14.

UniProtKB/Swiss-Prot: RGS12_HUMAN, O14924
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form
Function: Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase
DNA synthesis

Gene Wiki entry for RGS12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS12 gene promoter:
         Max1   ER-alpha   AML1a   p53   RelA   Evi-1   AREB6   S8   Zic3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RGS12 promoter sequence
   Search Chromatin IP Primers for RGS12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

RGS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS12 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003294:  view genomic region     (about GC identifiers)

Start:
3,294,755 bp from pter      End:
3,441,640 bp from pter
Size:
146,886 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RGS12

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGS12_HUMAN, O14924 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 12  
Size: 1447 amino acids; 156357 Da
Subunit: Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent (By similarity)
2 PDB 3D structures from and Proteopedia for RGS12:
2EBZ (3D)        2KV8 (3D)    
Secondary accessions: B1AQ30 B1AQ31 B1AQ32 E7EMN9 O14922 O14923 O43510 O75338 Q147X0 Q8WX95
Alternative splicing: 6 isoforms:  O14924-1   O14924-2   O14924-3   O14924-4   O14924-5   O14924-6   

Explore the universe of human proteins at neXtProt for RGS12: NX_O14924

Explore proteomics data for RGS12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1115
  • Modification sites at PhosphoSitePlus

  • See RGS12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002917.1  NP_937870.1  NP_937872.1  

    ENSEMBL proteins: 
     ENSP00000339381   ENSP00000424251   ENSP00000372238   ENSP00000342133   ENSP00000338509  
     ENSP00000440566   ENSP00000304459   ENSP00000438888  
    Reactome Protein details: O14924

    RGS12 Human Recombinant Protein Products:

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    Novus Biologicals RGS12 Proteins
    Novus Biologicals RGS12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RGS12

     
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    Search eBioscience for ELISAs for RGS12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    Selected InterPro protein domains (see all 8):
     IPR024066 Regulat_G_prot_signal_dom1
     IPR003116 Raf-like_ras-bd
     IPR003109 GoLoco_motif
     IPR011993 PH_like_dom
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry O14924

    ProtoNet protein and cluster: O14924

    5 Blocks protein domains:
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB003109 G-alpha GTPase activator
    IPB003116 Raf-like Ras-binding
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: RGS12_HUMAN, O14924
    Domain: The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3 (By similarity)
    Similarity: Contains 1 GoLoco domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PID domain
    Similarity: Contains 2 RBD (Ras-binding) domains
    Similarity: Contains 1 RGS domain


    Find genes that share domains with RGS12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS12_HUMAN, O14924
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form
    Function: Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase
    DNA synthesis

         Genatlas biochemistry entry for RGS12:
    negative regulator of G protein signaling 12,functioning as GTPase-activating protein for G protein alpha i and q
    subunits,with four alternatively spliced isoforms,highly expressed in brain,kidney,thymus,prostate,C elegans
    EGL-10 and yeast SST2 homolog

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0030695GTPase regulator activity IDA9651375
         
    Find genes that share ontologies with RGS12           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RGS12:
     Decreased cilium length after   Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rgs12):
     hematopoietic system  immune system  normal  skeleton 

    Find genes that share phenotypes with RGS12           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgs12tm1Lex for RGS12

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RGS12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGS12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGS12

    miRNA
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    hsa-mir-149-5p (MIRT045473), hsa-mir-138-5p (MIRT045830)

    Block miRNA regulation of human, mouse, rat RGS12 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RGS12:
    hsa-miR-526b hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RGS12 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RGS12

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGS12_HUMAN, O14924: Nucleus
    RGS12_HUMAN, O14924: Isoform 5: Nucleus matrix. Note=Also localized to discrete nuclear foci that are distinct
    from sites of RNA processing, PML nuclear bodies, and PcG domains
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000794condensed nuclear chromosome TAS10869340
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IBA--

    Find genes that share ontologies with RGS12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS12 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    3Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    4Peptide ligand-binding receptors
    G alpha (i) signalling events0.44


    Find genes that share SuperPaths with RGS12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS12
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    1 Reactome Pathway for RGS12
        G alpha (i) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Array including RGS12: 
              Leukemia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RGS12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for RGS12 (O149242, 3 ENSP000003393814) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB3P051062, 3MINT-45916 I2D: score=2 
    ITGB1P055562, 3MINT-45935 I2D: score=1 
    ITGB7P260102, 3MINT-45915 I2D: score=1 
    BCRP112742, 3, ENSP000003035074MINT-69542 I2D: score=1 STRING: ENSP00000303507
    HRASP011123, ENSP000003098454I2D: score=4 STRING: ENSP00000309845
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0007165signal transduction ----
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS9651375
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS9651375

    Find genes that share ontologies with RGS12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGS12 gene (7 alternative transcripts): 
    NM_002926.3  NM_198227.1  NM_198229.2  NM_198230.1  NM_198430.1  NM_198432.1  NM_198587.1  

    Unigene Cluster for RGS12:

    Regulator of G-protein signaling 12
    Hs.527061  [show with all ESTs]
    Unigene Representative Sequence: NM_002926
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000506631(uc010ics.1) ENST00000344733(uc003ggw.3 uc003ggy.1)
    ENST00000502947(uc003ggx.1) ENST00000514268(uc011bvr.1) ENST00000382788(uc011bvs.2)
    ENST00000511805 ENST00000513784 ENST00000338806(uc003ggz.3) ENST00000506998(uc010ict.1)
    ENST00000508158(uc010icu.1) ENST00000505570 ENST00000512990 ENST00000503041
    ENST00000504194(uc003gha.3 uc010icv.3) ENST00000512266 ENST00000513991(uc003ghb.2)
    ENST00000515521 ENST00000510803
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate RGS12:
    hsa-miR-526b hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RGS12 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): RGS12 (NM_002926)
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat RGS12

    Additional mRNA sequence: 

    AF030109.1 AF030110.1 AF030111.1 AF035152.1 AF464735.1 AF464736.1 AF464737.1 AK123325.1 
    AK290805.1 AK293767.1 AK301510.1 AK303135.1 AK308734.1 AK310999.1 AY987042.1 BC012118.1 
    BC028154.1 BC106944.1 BC118594.1 

    22 DOTS entries:

    DT.100795518  DT.100795519  DT.92429869  DT.455298  DT.101983738  DT.40132607  DT.101983740  DT.116803 
    DT.95274682  DT.99974025  DT.100795513  DT.92429866  DT.100721399  DT.95312695  DT.92054661  DT.116804 
    DT.121269468  DT.121269477  DT.40225421  DT.95362660  DT.100801601  DT.91898055 

    Selected AceView cDNA sequences (see all 278):

    AI298195 AI492460 BX106958 AF464735 AI697612 BM722045 AI674068 CD673811 
    CA448454 BI752801 NM_198587 AI424666 BM984992 BU739704 AF030110 NM_198230 
    AI692894 AI094724 BF591183 BQ000089 BQ960951 AI089751 AA974676 AW301119 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RGS12 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:                                            -     -     -                             -                                               -           -         
    SP2:                                            -     -     -                             -                                               -           -         
    SP3:                                                                                      -                                               -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for RGS12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCCCTG
    RGS12 Expression
    About this image


    RGS12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    RGS12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527061

    UniProtKB/Swiss-Prot: RGS12_HUMAN, O14924
    Tissue specificity: Isoform 3 is brain specific

        Pathway & Disease-focused RT2 Profiler PCR Array including RGS12: 
              Leukemia in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGS12 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs121 , 5 regulator of G-protein signaling 121, 5 82.47(n)1
    85.99(a)1
      5 (17.96 cM)5
    717291  NM_173402.21  NP_775578.21 
     349494455 
    chicken
    (Gallus gallus)
    Aves RGS121 regulator of G-protein signaling 12 69.85(n)
    73.87(a)
      395619  XM_420820.4  XP_420820.3 
    lizard
    (Anolis carolinensis)
    Reptilia RGS126
    regulator of G-protein signaling 12
    67(a)
    1 ↔ 1
    GL343236.1(2113285-2232050)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480597302   -- 75.65(n)    48059730 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.186942 Danio rerio RGS12TS-S mRNA, complete cds, alternatively more 75.13(n)    AY427669.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta loco6
    locomotion defects
    22(a)
    1 → many
    3R(18445690-18465082)
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-76
    Protein RGS-7, isoform b
    14(a)
    1 → many
    X(3542558-3557594) WBGene00004350


    ENSEMBL Gene Tree for RGS12 (if available)
    TreeFam Gene Tree for RGS12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS12 gene
    RGS142  RGS112  RGS102  RGS72  RGS62  RGS92  
    12 SIMAP similar genes for RGS12 using alignment to 7 protein entries:     RGS12_HUMAN (see all proteins):
    DKFZp761K1617    RGS10    RGS4    RGS17    RGS3    RGS14
    RGS5    RGS16    RGS19    RGS1    RGS13    RGS8

    Find genes that share paralogs with RGS12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS12 (see all 2928)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs74356011,2
    C,F,H--3307221(+) GGGCTC/TTGCGA 1 -- us2k128Minor allele frequency- T:0.24NS EA NA WA CSA 2776
    rs1433088091,2
    --3307225(+) TTTGCA/GAATAA 1 -- us2k10--------
    rs1143304131,2
    C,F--3307274(+) GTCCTC/TGATGG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1421395321,2
    --3313893(+) TTCAGC/TTGGAA 2 -- us2k10--------
    rs1897345891,2
    --3313968(+) AGTTTA/TAAAAA 2 -- us2k10--------
    rs1929414151,2
    C--3313998(+) ACTTAC/TGTGAT 2 -- us2k10--------
    rs1497233121,2
    --3313999(+) CTTATA/GTGATT 2 -- us2k10--------
    rs1840486081,2
    --3314007(+) ATTATA/TTTGGG 2 -- us2k10--------
    rs2011272401,2
    --3314114(+) AGGTT-/CACTGG 2 -- us2k10--------
    rs800129751,2
    C,F--3314148(+) CCCACG/ATGGTG 2 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for RGS12 (3294755 - 3441640 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RGS12 (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726881CNV Deletion23290073
    esv1534592CNV Deletion17803354
    esv2726882CNV Deletion23290073
    esv2726880CNV Deletion23290073
    esv2726879CNV Deletion23290073
    esv2328657CNV Deletion18987734
    esv2726877CNV Deletion23290073
    esv2726878CNV Deletion23290073
    esv3639CNV Deletion18987735
    esv2677000CNV Deletion23128226

    Human Gene Mutation Database (HGMD): RGS12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS12
    DNA2.0 Custom Variant and Variant Library Synthesis for RGS12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602512    OMIM disorders: --


    Find genes that share disorders with RGS12           About GenesLikeMe

    Genetic Association Database (GAD): RGS12
    Human Genome Epidemiology (HuGE) Navigator: RGS12 (4 documents)

    Export disorders for RGS12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS12 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with RGS12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. (PubMed id 9651375)1, 2, 3, 9 Snow B.E....Siderovski D.P. (J. Biol. Chem. 1998)
    2. Novel alternative splicing and nuclear localization of human RGS12 gene products. (PubMed id 10869340)1, 2, 9 Chatterjee T.K. and Fisher R.A. (J. Biol. Chem. 2000)
    3. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (Carcinogenesis 2010)
    4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    6. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    7. RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression. (PubMed id 12024043)1, 2 Chatterjee T.K. and Fisher R.A. (Mol. Cell. Biol. 2002)
    8. Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. (PubMed id 11130074)1, 9 Schiff M.L....DiversAc-Pierluissi M. (Nature 2000)
    9. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (Nat. Genet. 2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6002 HGNC: 9994 AceView: RGS12 Ensembl:ENSG00000159788 euGenes: HUgn6002
    ECgene: RGS12 H-InvDB: RGS12

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RGS12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS12 gene:
    Search GeneIP for patents involving RGS12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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