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RGS11 Gene

protein-coding   GIFtS: 62
GCID: GC16M000318

Regulator Of G-Protein Signaling 11

(Previous name: regulator of G-protein signalling 11)
  See RGS11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 111 2
Regulator Of G-Protein Signalling 111 2
RS112 5

External Ids:    HGNC: 99931   Entrez Gene: 87862   Ensembl: ENSG000000763447   OMIM: 6038955   UniProtKB: O948103   

Export aliases for RGS11 gene to outside databases

Previous GC identifers: GC16M000337 GC16M000259 GC16M000260 GC16M000261


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS11 Gene:
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS
family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins.
This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby
driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript
variants encoding distinct isoforms have been identified. (provided by RefSeq, Nov 2013)

GeneCards Summary for RGS11 Gene:
RGS11 (regulator of G-protein signaling 11) is a protein-coding gene. Diseases associated with RGS11 include hereditary night blindness. GO annotations related to this gene include GTPase activator activity and signal transducer activity. An important paralog of this gene is RGS14.

UniProtKB/Swiss-Prot: RGS11_HUMAN, O94810
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form

Gene Wiki entry for RGS11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS11 gene promoter:
         Lmo2   AP-2gamma   Evi-1   COMP1   AP-2beta   AP-2alpha   NF-Y   AP-2alphaA   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RGS11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RGS11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS11 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000318:  view genomic region     (about GC identifiers)

Start:
318,300 bp from pter      End:
325,980 bp from pter
Size:
7,681 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGS11_HUMAN, O94810 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 11  
Size: 467 amino acids; 52946 Da
Subunit: Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the
heterodimer formed with Gbeta5 (By similarity)
Secondary accessions: O75883 Q4TT71 Q4TT72
Alternative splicing: 3 isoforms:  O94810-1   O94810-2   O94810-3   

Explore the universe of human proteins at neXtProt for RGS11: NX_O94810

Explore proteomics data for RGS11 at MOPED


See RGS11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001273414.1  NP_001273415.1  NP_003825.1  NP_899180.1  

ENSEMBL proteins: 
 ENSP00000380876   ENSP00000168869   ENSP00000319069   ENSP00000352778   ENSP00000380874  
 ENSP00000411215  
Reactome Protein details: O94810

RGS11 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for RGS11

 
Search eBioscience for Proteins for RGS11 

RGS11 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of RGS11
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RGS: Regulators of G-protein signaling

Selected InterPro protein domains (see all 6):
 IPR024066 Regulat_G_prot_signal_dom1
 IPR011991 WHTH_DNA-bd_dom
 IPR016137 Regulat_G_prot_signal_superfam
 IPR000342 RGS_dom
 IPR000591 DEP_dom

Graphical View of Domain Structure for InterPro Entry O94810

ProtoNet protein and cluster: O94810

3 Blocks protein domains:
IPB000342 Regulator of G-protein signalling (RGS) protein signature
IPB000591 Pleckstrin putative G-protein interacting domain
IPB001770 Gamma G-protein (transducin) signature


UniProtKB/Swiss-Prot: RGS11_HUMAN, O94810
Similarity: Contains 1 DEP domain
Similarity: Contains 1 G protein gamma domain
Similarity: Contains 1 RGS domain


Find genes that share domains with RGS11           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RGS11_HUMAN, O94810
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form

     Genatlas biochemistry entry for RGS11:
negative regulator of G protein signaling 11,predominantly expressed in both brain and retina,functioning as
GTPase-activating protein for G protein alpha subunits,G alpha i, G alpha o and complexing with G beta 5

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004871signal transducer activity IEA--
GO:0005096GTPase activator activity IBA--
GO:0031681G-protein beta-subunit binding IPI12606627
     
Find genes that share ontologies with RGS11           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for RGS11:
 Increased S DNA content 

     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgs11):
 mortality/aging  nervous system  reproductive system  vision/eye 

Find genes that share phenotypes with RGS11           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Rgs11tm1Lex for RGS11

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RGS11
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RGS11

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGS11
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGS11

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat RGS11

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): RGS11 (NM_183337)
Sino Biological Human cDNA Clone for RGS11
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS11
Addgene plasmids for RGS11 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS11


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
plasma membrane3
nucleus2
mitochondrion1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IBA--
GO:0005834heterotrimeric G-protein complex IEA--
GO:0005886plasma membrane IBA--
GO:0043234protein complex IDA18468998
GO:0044292dendrite terminus IEA--

Find genes that share ontologies with RGS11           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RGS11 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
2G-AlphaQ Signaling
G-AlphaQ Signaling0.47
G-AlphaI Signaling0.47
3Myometrial Relaxation and Contraction Pathways
Myometrial Relaxation and Contraction Pathways0.43
Calcium Regulation in the Cardiac Cell0.43
4Activation of cAMP-Dependent PKA
cAMP Pathway0.77
5G protein signaling G Protein alpha i signaling cascades
G protein signaling G Protein alpha i signaling cascades0.55


Find genes that share SuperPaths with RGS11           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS11
    cAMP Pathway
G-AlphaI Signaling
G-AlphaQ Signaling

1 GeneGo (Thomson Reuters) Pathway for RGS11
    G-protein signaling G-Protein alpha-i signaling cascades

2 BioSystems Pathways for RGS11
    Myometrial Relaxation and Contraction Pathways
Calcium Regulation in the Cardiac Cell


1 Reactome Pathway for RGS11
    G alpha (i) signalling events


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS11
Interactions:

    Search GeneGlobe Interaction Network for RGS11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RGS11 (O948103 ENSP000003808764) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
InteractantInteraction Details
GeneCardExternal ID(s)
GNB5O147753, ENSP000002618374I2D: score=1 STRING: ENSP00000261837
GNA11ENSP000000784294STRING: ENSP00000078429
GNA12ENSP000002753644STRING: ENSP00000275364
GNA13ENSP000004007174STRING: ENSP00000400717
GNA14ENSP000003658074STRING: ENSP00000365807
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway IEA--
GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS9789084
GO:0035556intracellular signal transduction IEA--
GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
GO:0043547positive regulation of GTPase activity TAS9789084

Find genes that share ontologies with RGS11           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RGS11



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RGS11 gene (4 alternative transcripts): 
NM_001286485.1  NM_001286486.1  NM_003834.2  NM_183337.2  

Unigene Cluster for RGS11:

Regulator of G-protein signaling 11
Hs.65756  [show with all ESTs]
Unigene Representative Sequence: AB209582
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000397770(uc002cgj.1) ENST00000168869(uc002cgk.1) ENST00000316163(uc002cgi.1 uc010bqs.1)
ENST00000477143 ENST00000359740 ENST00000481672 ENST00000493449(uc010uue.2)
ENST00000472466 ENST00000397768 ENST00000431291
miRNA
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Search for qRT-PCR Assays for microRNAs that regulate RGS11
SwitchGear 3'UTR luciferase reporter plasmidRGS11 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RGS11
Predesigned siRNA for gene silencing in human, mouse, rat RGS11
Clone
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OriGene ORF clones in mouse, rat for RGS11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RGS11 (NM_183337)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RGS11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RGS11
Addgene plasmids for RGS11 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for RGS11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RGS11
  QuantiTect SYBR Green Assays in human, mouse, rat RGS11
  QuantiFast Probe-based Assays in human, mouse, rat RGS11

Additional mRNA sequence: 

AB016929.1 AB209582.1 AF035153.1 AF035154.1 AK091701.1 AK293564.1 AK294033.1 AK294448.1 
AK308972.1 BC040504.1 BC141803.1 DQ656000.2 DQ656001.2 EF212269.1 

8 DOTS entries:

DT.100020012  DT.307442  DT.99954033  DT.120711778  DT.120711872  DT.100740336  DT.120711834  DT.120711836 

Selected AceView cDNA sequences (see all 41):

NM_183337 AB016929 NM_003834 BX507622 BE047585 AL539076 AF035154 AF035153 
CA391209 AL045210 BX955418 BF352690 CR593949 BI770147 BE218137 CK299324 
BF352695 CB144681 BQ067240 BQ002302 AL138125 BF338370 BG819255 BM926869 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RGS11    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:                                                  -     -           -                           
SP2:              -     -                 -                                                         
SP3:                    -                 -                                                         
SP4:                                                                                                
SP5:                                      -                                                         


ECgene alternative splicing isoforms for RGS11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RGS11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGGTCTCGG
RGS11 Expression
About this image


RGS11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Metencephalon
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Medulla Oblongata
 
 Neurons
         Mature Horizontal Cells Inner Nuclear Layer
 
 Eye (Sensory Organs)
         Mature Horizontal Cells Inner Nuclear Layer
RGS11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RGS11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.65756
    Custom PCR Arrays for RGS11
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for RGS11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RGS11
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QuantiFast Probe-based Assays in human, mouse, rat RGS11
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RGS11 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rgs111 , 5 regulator of G-protein signaling 111, 5 81.89(n)1
79.96(a)1
  17 (13.07 cM)5
507821  NM_001081069.11  NP_001074538.11 
 262029515 
chicken
(Gallus gallus)
Aves RGS111 regulator of G-protein signaling 11 75.68(n)
72.07(a)
  395621  XM_001231807.3  XP_001231808.2 
lizard
(Anolis carolinensis)
Reptilia RGS116
regulator of G-protein signaling 11
75(a)
1 ↔ 1
GL343507.1(540857-541523)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rgs91 regulator of G-protein signaling 9 69.66(n)
68.89(a)
  100125123  NM_001103027.1  NP_001096497.1 
zebrafish
(Danio rerio)
Actinopterygii rgs111 regulator of G-protein signaling 11 65.49(n)
61.65(a)
  559197  NM_001111161.1  NP_001104631.1 
fruit fly
(Drosophila melanogaster)
Insecta CG70953 regulation of G-protein coupled
receptor protein more
41(a)   17E1   --
worm
(Caenorhabditis elegans)
Secernentea eat-166
Protein EAT-16, isoform a
30(a)
many ↔ many
I(9722550-9726263) WBGene00001145


ENSEMBL Gene Tree for RGS11 (if available)
TreeFam Gene Tree for RGS11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RGS11 gene
RGS142  RGS122  RGS102  RGS72  RGS62  RGS92  
14 SIMAP similar genes for RGS11 using alignment to 7 protein entries:     RGS11_HUMAN (see all proteins):
RGS9    RGS17    RGS19    RGS20    RGS3    RGS10
RGS4    RGS13    RGS5    RGS7    RGS6    RGS18
RGS8    RGS16

Find genes that share paralogs with RGS11           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RGS11 (see all 465)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3733084561,2
C--317854(+) TGCCT-/CACAGTG 2 -- int10--------
rs355272391,2
C--317878(+) CTACAC/TGACAC 2 -- int11Minor allele frequency- T:0.50NA 2
rs1182018751,2
C--317884(+) GACACG/ATGCAC 2 -- int11Minor allele frequency- A:0.50WA 2
rs49848571,2
C,F,A,H--318050(+) acgggC/Tgctac 2 -- int118Minor allele frequency- T:0.03NS NA WA CSA EA 1872
rs1836375581,2
--318051(+) CGGGTA/GCTACA 2 -- int10--------
rs727658251,2
C--318077(+) TATGCG/ATACAC 2 -- int16Minor allele frequency- A:0.18NA CSA WA EA 362
rs1427674161,2
C--318154(+) TGCCT-/CACAGTA 2 -- int10--------
rs721324861,2
C--318155(+) GCCTC-/CAAGTAC 2 -- int10--------
rs2008581711,2
C--318171(+) CACACA/GTGCAC 2 -- int10--------
rs1125777131,2
C--318179(+) CACTAC/AACACA 2 -- int11Minor allele frequency- A:0.50CSA 2

HapMap Linkage Disequilibrium report for RGS11 (318300 - 325980 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RGS11 (see all 14):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422427CNV Duplication17116639
nsv904690CNV Loss21882294
nsv904674CNV Loss21882294
dgv2465n71CNV Loss21882294
dgv2470n71CNV Loss21882294
nsv904677CNV Loss21882294
dgv2458n71CNV Loss21882294
dgv2469n71CNV Loss21882294
dgv32n68CNV Loss17160897
dgv2468n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603895    OMIM disorders: --

1 disease for RGS11:    
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hereditary night blindness

1 disease from the University of Copenhagen DISEASES database for RGS11:
Hereditary night blindness

Find genes that share disorders with RGS11           About GenesLikeMe

Genetic Association Database (GAD): RGS11
Human Genome Epidemiology (HuGE) Navigator: RGS11 (2 documents)

Export disorders for RGS11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RGS11 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with RGS11)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. (PubMed id 9789084)1, 2, 3 Snow B.E.... Siderovski D.P. (Proc. Natl. Acad. Sci. U.S.A. 1998)
  2. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (Carcinogenesis 2010)
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
  4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
  6. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. (PubMed id 10339615)1, 2 Snow B.E.... Siderovski D.P. (Proc. Natl. Acad. Sci. U.S.A. 1999)
  7. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
  8. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
  9. RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11. (PubMed id 19497306)1 Saleem Y. and Kim K.S. (Biochem. Biophys. Res. Commun. 2009)
  10. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8786 HGNC: 9993 AceView: RGS11 Ensembl:ENSG00000076344 euGenes: HUgn8786
ECgene: RGS11 H-InvDB: RGS11

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RGS11 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RGS11 gene:
Search GeneIP for patents involving RGS11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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