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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS11 Gene

protein-coding   GIFtS: 63
GCID: GC16M000318

Regulator Of G-Protein Signaling 11

(Previous name: regulator of G-protein signalling 11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 111 2
Regulator Of G-Protein Signalling 111 2
RS112 5

External Ids:    HGNC: 99931   Entrez Gene: 87862   Ensembl: ENSG000000763447   OMIM: 6038955   UniProtKB: O948103   

Export aliases for RGS11 gene to outside databases

Previous GC identifers: GC16M000337 GC16M000259 GC16M000260 GC16M000261


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS11 Gene:
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS
family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins.
This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby
driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript
variants encoding distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS11 Gene: 
RGS11 (regulator of G-protein signaling 11) is a protein-coding gene. Diseases associated with RGS11 include hereditary night blindness, and esophageal adenocarcinoma, and among its related super-pathways are G-AlphaQ Signaling and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include GTPase activator activity and signal transducer activity. An important paralog of this gene is RGS14.

UniProtKB/Swiss-Prot: RGS11_HUMAN, O94810
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form

Gene Wiki entry for RGS11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS11 gene promoter:
         Lmo2   AP-2gamma   Evi-1   COMP1   AP-2beta   AP-2alpha   NF-Y   AP-2alphaA   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RGS11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RGS11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS11 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000318:  view genomic region     (about GC identifiers)

Start:
318,300 bp from pter      End:
325,980 bp from pter
Size:
7,681 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGS11_HUMAN, O94810 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 11  
Size: 467 amino acids; 52946 Da
Subunit: Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the
heterodimer formed with Gbeta5 (By similarity)
Secondary accessions: O75883 Q4TT71 Q4TT72
Alternative splicing: 3 isoforms:  O94810-1   O94810-2   O94810-3   

Explore the universe of human proteins at neXtProt for RGS11: NX_O94810

Explore proteomics data for RGS11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94810

  • RGS11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGS11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003825.1  NP_899180.1  

    ENSEMBL proteins: 
     ENSP00000380876   ENSP00000168869   ENSP00000319069   ENSP00000352778   ENSP00000380874  
     ENSP00000411215  

    Human Recombinant Protein Products for RGS11: 
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    Novus Biologicals RGS11 Proteins
    Novus Biologicals RGS11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RGS11 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005834heterotrimeric G-protein complex IEA--
    GO:0005886plasma membrane IBA--
    GO:0043234protein complex IDA18468998
    GO:0044292dendrite terminus IEA--

    RGS11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RGS: Regulators of G-protein signaling

    5/6 InterPro protein domains (see all 6):
     IPR024066 Regulat_G_prot_signal_dom1
     IPR011991 WHTH_DNA-bd_dom
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000591 DEP_dom

    Graphical View of Domain Structure for InterPro Entry O94810

    ProtoNet protein and cluster: O94810

    3 Blocks protein domains:
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000591 Pleckstrin putative G-protein interacting domain
    IPB001770 Gamma G-protein (transducin) signature


    UniProtKB/Swiss-Prot: RGS11_HUMAN, O94810
    Similarity: Contains 1 DEP domain
    Similarity: Contains 1 G protein gamma domain
    Similarity: Contains 1 RGS domain


    RGS11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS11_HUMAN, O94810
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form

         Genatlas biochemistry entry for RGS11:
    negative regulator of G protein signaling 11,predominantly expressed in both brain and retina,functioning as
    GTPase-activating protein for G protein alpha subunits,G alpha i, G alpha o and complexing with G beta 5

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005096GTPase activator activity IBA--
         
    RGS11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RGS11:
     Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgs11):
     mortality/aging  nervous system  reproductive system  vision/eye 

    RGS11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rgs11tm1Lex for RGS11

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGS11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGS11

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGS11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    3Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    4G-protein signaling G-Protein alpha-i signaling cascades
    G-protein signaling G-Protein alpha-i signaling cascades0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RGS11
        G-protein signaling G-Protein alpha-i signaling cascades

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS11
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    1 GeneGo (Thomson Reuters) Pathway for RGS11
        G-protein signaling G-Protein alpha-i signaling cascades

    2 BioSystems Pathways for RGS11
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell




    RGS11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGS11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for RGS11 (O948103 ENSP000003808764) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB5O147753, ENSP000002618374I2D: score=1 STRING: ENSP00000261837
    GNA11ENSP000000784294STRING: ENSP00000078429
    GNA12ENSP000002753644STRING: ENSP00000275364
    GNA13ENSP000004007174STRING: ENSP00000400717
    GNA14ENSP000003658074STRING: ENSP00000365807
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS9789084
    GO:0035556intracellular signal transduction IEA--
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS9789084

    RGS11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS11

    Search CenterWatch for drugs/clinical trials and news about RGS11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGS11 gene (2 alternative transcripts): 
    NM_003834.1  NM_183337.1  

    Unigene Cluster for RGS11:

    Regulator of G-protein signaling 11
    Hs.65756  [show with all ESTs]
    Unigene Representative Sequence: AB209582
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397770(uc002cgj.1) ENST00000168869(uc002cgk.1) ENST00000316163(uc002cgi.1 uc010bqs.1)
    ENST00000477143 ENST00000359740 ENST00000481672 ENST00000493449(uc010uue.2)
    ENST00000472466 ENST00000397768 ENST00000431291
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS11

    Additional mRNA sequence: 

    AB016929.1 AB209582.1 AF035153.1 AF035154.1 AK091701.1 AK293564.1 AK294033.1 AK294448.1 
    AK308972.1 BC040504.1 BC141803.1 DQ656000.2 DQ656001.2 EF212269.1 

    8 DOTS entries:

    DT.100020012  DT.307442  DT.99954033  DT.120711778  DT.120711872  DT.100740336  DT.120711834  DT.120711836 

    24/41 AceView cDNA sequences (see all 41):

    BI770147 AB016929 BF352690 BE047585 NM_003834 AF035153 BX507622 AL539076 
    NM_183337 AL045210 AF035154 BX955418 CR593949 CA391209 BQ002302 AK091701 
    BP359924 BE218137 BF339342 BG819255 CB144681 BF338370 BX089104 BC040504 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RGS11    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                  -     -           -                           
    SP2:              -     -                 -                                                         
    SP3:                    -                 -                                                         
    SP4:                                                                                                
    SP5:                                      -                                                         


    ECgene alternative splicing isoforms for RGS11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS11 expression in normal human tissues (normalized intensities)      RGS11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTCTCGG
    RGS11 Expression
    About this image


    RGS11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Medulla Oblongata
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             autonomic/nerve plexus/hypogastric plexus   
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Fibroblast
             Human Dermal Fibroblasts-neonate (HDF-n)   

    See RGS11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS11

    SOURCE GeneReport for Unigene cluster: Hs.65756
        SABiosciences Custom PCR Arrays for RGS11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGS11 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs111 , 5 regulator of G-protein signaling 111, 5 81.47(n)1
    79.21(a)1
      17 (13.07 cM)5
    507821  NM_001081069.11  NP_001074538.11 
     262029515 
    chicken
    (Gallus gallus)
    Aves RGS111 regulator of G-protein signaling 11 74.89(n)
    70.96(a)
      395621  XM_001231807.2  XP_001231808.2 
    lizard
    (Anolis carolinensis)
    Reptilia RGS116
    Uncharacterized protein
    75(a)
    1 ↔ 1
    GL343507.1(540857-541523)
    zebrafish
    (Danio rerio)
    Actinopterygii rgs111 regulator of G-protein signaling 11 64.91(n)
    61.88(a)
      559197  NM_001111161.1  NP_001104631.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70953
    CG424501
    regulation of G-protein coupled
    receptor protein more3
    CG424501
    41(a)3
    52.38(n)1
    42.18(a)1
      17E13
    328741  NM_133100.21  NP_573328.21 
    worm
    (Caenorhabditis elegans)
    Secernentea eat-166
    Protein EAT-16, isoform a
    30(a)
    1 → many
    I(9722550-9725611)


    ENSEMBL Gene Tree for RGS11 (if available)
    TreeFam Gene Tree for RGS11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS11 gene
    RGS142  RGS122  RGS102  RGS72  RGS62  RGS92  
    14 SIMAP similar genes for RGS11 using alignment to 7 protein entries:     RGS11_HUMAN (see all proteins):
    RGS9    RGS17    RGS19    RGS20    RGS3    RGS10
    RGS4    RGS13    RGS5    RGS7    RGS6    RGS18
    RGS8    RGS16

    RGS11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/465 SNPs in RGS11 are shown (see all 465)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3733084561,2
    C--317854(+) TGCCT-/CACAGTG 2 -- int10--------
    rs355272391,2
    C--317878(+) CTACAC/TGACAC 2 -- int11Minor allele frequency- T:0.50NA 2
    rs1182018751,2
    C--317884(+) GACACG/ATGCAC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs49848571,2
    C,F,A,H--318050(+) acgggC/Tgctac 2 -- int118Minor allele frequency- T:0.03NS NA WA CSA EA 1872
    rs1836375581,2
    --318051(+) CGGGTA/GCTACA 2 -- int10--------
    rs727658251,2
    C--318077(+) TATGCG/ATACAC 2 -- int16Minor allele frequency- A:0.18NA CSA WA EA 362
    rs1427674161,2
    C--318154(+) TGCCT-/CACAGTA 2 -- int10--------
    rs721324861,2
    C--318155(+) GCCTC-/CAAGTAC 2 -- int10--------
    rs2008581711,2
    C--318171(+) CACACA/GTGCAC 2 -- int10--------
    rs1125777131,2
    C--318179(+) CACTAC/AACACA 2 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for RGS11 (318300 - 325980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for RGS11 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv904690CNV Loss21882294
    nsv904674CNV Loss21882294
    dgv2465n71CNV Loss21882294
    dgv2470n71CNV Loss21882294
    nsv904677CNV Loss21882294
    dgv2458n71CNV Loss21882294
    dgv2469n71CNV Loss21882294
    dgv32n68CNV Loss17160897
    dgv2468n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603895    OMIM disorders: --

    9 diseases for RGS11:    About MalaCards
    hereditary night blindness    esophageal adenocarcinoma    retinoschisis    pharyngitis
    night blindness    blindness    esophagitis    squamous cell carcinoma
    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for RGS11:
    Hereditary night blindness

    RGS11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS11
    Human Genome Epidemiology (HuGE) Navigator: RGS11 (2 documents)

    Export disorders for RGS11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS11 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with RGS11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. (PubMed id 9789084)1, 2, 3 Snow B.E.... Siderovski D.P. (1998)
    2. Genetic variations in regulator of G-protein signalin g genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (2010)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    6. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. (PubMed id 10339615)1, 2 Snow B.E.... Siderovski D.P. (1999)
    7. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    8. Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (2010)
    9. RGS11 interacts preferentially with R7BP over Galpha( oa)--characterization of Gbeta5-free RGS11. (PubMed id 19497306)1 Saleem Y. and Kim K.S. (2009)
    10. Blood pressure is regulated by an alpha1D-adrenergic r eceptor/dystrophin signalosome. (PubMed id 18468998)1 Lyssand J.S....Hague C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8786 HGNC: 9993 AceView: RGS11 Ensembl:ENSG00000076344 euGenes: HUgn8786
    ECgene: RGS11 H-InvDB: RGS11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGS11 gene:
    Search GeneIP for patents involving RGS11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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