Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RGS11 Gene

Aliases for RGS11 Gene

  • Regulator Of G-Protein Signaling 11 2 3 5
  • Regulator Of G-Protein Signalling 11 2 3
  • RS11 3

External Ids for RGS11 Gene

Previous GeneCards Identifiers for RGS11 Gene

  • GC16M000337
  • GC16M000259
  • GC16M000260
  • GC16M000261
  • GC16M000318

Summaries for RGS11 Gene

Entrez Gene Summary for RGS11 Gene

  • The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

GeneCards Summary for RGS11 Gene

RGS11 (Regulator Of G-Protein Signaling 11) is a Protein Coding gene. Diseases associated with RGS11 include congenital stationary night blindness. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include signal transducer activity and G-protein beta-subunit binding. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot for RGS11 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Gene Wiki entry for RGS11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS11 Gene

Genomics for RGS11 Gene

Regulatory Elements for RGS11 Gene

Promoters for RGS11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGS11 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS11 Gene

Chromosome:
16
Start:
268,301 bp from pter
End:
275,980 bp from pter
Size:
7,680 bases
Orientation:
Minus strand

Genomic View for RGS11 Gene

Genes around RGS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS11 Gene

Proteins for RGS11 Gene

  • Protein details for RGS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94810-RGS11_HUMAN
    Recommended name:
    Regulator of G-protein signaling 11
    Protein Accession:
    O94810
    Secondary Accessions:
    • O75883
    • Q4TT71
    • Q4TT72

    Protein attributes for RGS11 Gene

    Size:
    467 amino acids
    Molecular mass:
    52946 Da
    Quaternary structure:
    • Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).

    Alternative splice isoforms for RGS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS11 Gene

Proteomics data for RGS11 Gene at MOPED

Post-translational modifications for RGS11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS11 Gene

Antibody Products

No data available for DME Specific Peptides for RGS11 Gene

Domains & Families for RGS11 Gene

Gene Families for RGS11 Gene

Graphical View of Domain Structure for InterPro Entry

O94810

UniProtKB/Swiss-Prot:

RGS11_HUMAN :
  • Contains 1 DEP domain.
Domain:
  • Contains 1 DEP domain.
  • Contains 1 G protein gamma domain.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS11: view

Function for RGS11 Gene

Molecular function for RGS11 Gene

GENATLAS Biochemistry:
negative regulator of G protein signaling 11,predominantly expressed in both brain and retina,functioning as GTPase-activating protein for G protein alpha subunits,G alpha i, G alpha o and complexing with G beta 5
UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Gene Ontology (GO) - Molecular Function for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 9789084
genes like me logo Genes that share ontologies with RGS11: view
genes like me logo Genes that share phenotypes with RGS11: view

Animal Models for RGS11 Gene

MGI Knock Outs for RGS11:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS11 Gene

Localization for RGS11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS11 Gene COMPARTMENTS Subcellular localization image for RGS11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
GO:0043234 protein complex IDA 18468998
genes like me logo Genes that share ontologies with RGS11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGS11 Gene

Pathways & Interactions for RGS11 Gene

genes like me logo Genes that share pathways with RGS11: view

Pathways by source for RGS11 Gene

Gene Ontology (GO) - Biological Process for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity TAS 9789084
genes like me logo Genes that share ontologies with RGS11: view

No data available for SIGNOR curated interactions for RGS11 Gene

Drugs & Compounds for RGS11 Gene

No Compound Related Data Available

Transcripts for RGS11 Gene

Unigene Clusters for RGS11 Gene

Regulator of G-protein signaling 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for RGS11 Gene

GeneLoc Exon Structure for
RGS11
ECgene alternative splicing isoforms for
RGS11

Expression for RGS11 Gene

mRNA expression in normal human tissues for RGS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS11 Gene

This gene is overexpressed in Brain - Cerebellum (x8.3) and Brain - Cerebellar Hemisphere (x6.8).

SOURCE GeneReport for Unigene cluster for RGS11 Gene Hs.65756

genes like me logo Genes that share expression patterns with RGS11: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RGS11 Gene

Orthologs for RGS11 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS11 36
  • 93 (a)
OneToOne
RGS11 35
  • 93.76 (n)
  • 91.69 (a)
cow
(Bos Taurus)
Mammalia RGS11 35
  • 83.88 (n)
  • 80.26 (a)
RGS11 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS11 36
  • 75 (a)
OneToOne
RGS11 35
  • 81.32 (n)
  • 77.14 (a)
mouse
(Mus musculus)
Mammalia Rgs11 16
Rgs11 36
  • 78 (a)
OneToOne
Rgs11 35
  • 81.89 (n)
  • 79.96 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS11 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS11 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs11 35
  • 82.59 (n)
  • 80.8 (a)
chicken
(Gallus gallus)
Aves RGS11 35
  • 75.68 (n)
  • 72.07 (a)
-- 36
  • 68 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia RGS11 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs9 35
  • 69.66 (n)
  • 68.89 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs11 36
  • 60 (a)
OneToOne
rgs11 35
  • 65.49 (n)
  • 61.65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000232 35
  • 54.56 (n)
  • 42.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42450 36
  • 14 (a)
OneToMany
CG7095 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea eat-16 36
  • 30 (a)
ManyToMany
Species with no ortholog for RGS11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS11 Gene

ENSEMBL:
Gene Tree for RGS11 (if available)
TreeFam:
Gene Tree for RGS11 (if available)

Paralogs for RGS11 Gene

Paralogs for RGS11 Gene

genes like me logo Genes that share paralogs with RGS11: view

Variants for RGS11 Gene

Sequence variations from dbSNP and Humsavar for RGS11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_024606 -
rs9806942 - 270,760(+) ATCCA(C/G/T)CAGGG nc-transcript-variant, reference, missense
rs3809653 -- 276,455(+) GGGCC(G/T)GGGCC upstream-variant-2KB
rs3809654 -- 276,525(+) CATAC(A/C/G)TTGCT upstream-variant-2KB
rs3809655 -- 276,817(+) GGAGG(A/C)CCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RGS11 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2458n71 CNV Loss 21882294
nsv904652 CNV Loss 21882294
dgv32n68 CNV Loss 17160897
dgv2465n71 CNV Loss 21882294
dgv2466n71 CNV Loss 21882294
nsv904674 CNV Loss 21882294
nsv827477 CNV Gain 20364138
dgv2467n71 CNV Loss 21882294
nsv904677 CNV Loss 21882294
dgv2468n71 CNV Loss 21882294
dgv2469n71 CNV Loss 21882294
dgv2470n71 CNV Loss 21882294
nsv904690 CNV Loss 21882294

Variation tolerance for RGS11 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.01; 90.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS11 Gene

HapMap Linkage Disequilibrium report
RGS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS11 Gene

Disorders for RGS11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RGS11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards
Search RGS11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RGS11

Genetic Association Database (GAD)
RGS11
Human Genome Epidemiology (HuGE) Navigator
RGS11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS11
genes like me logo Genes that share disorders with RGS11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS11 Gene

Publications for RGS11 Gene

  1. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. (PMID: 9789084) Snow B.E. … Siderovski D.P. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. Differential expression of poliovirus receptor, regulator of G-protein signaling 11 and erythrocyte protein band 4.1-like 3 in human granulosa cells during follicular growth and maturation. (PMID: 24828608) Barzilay E. … Hourvitz A. (Gynecol. Endocrinol. 2014) 3
  3. CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human I^a88-adrenergic receptor. (PMID: 24561123) Kittanakom S. … Stagljar I. (Biochem. Biophys. Res. Commun. 2014) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3

Products for RGS11 Gene

Sources for RGS11 Gene

Back to Top

Content