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Aliases for RGS11 Gene

Aliases for RGS11 Gene

  • Regulator Of G-Protein Signaling 11 2 3
  • Regulator Of G-Protein Signalling 11 2 3
  • RS11 3 6

External Ids for RGS11 Gene

Previous GeneCards Identifiers for RGS11 Gene

  • GC16M000337
  • GC16M000259
  • GC16M000260
  • GC16M000261
  • GC16M000318

Summaries for RGS11 Gene

Entrez Gene Summary for RGS11 Gene

  • The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

GeneCards Summary for RGS11 Gene

RGS11 (Regulator Of G-Protein Signaling 11) is a Protein Coding gene. Diseases associated with RGS11 include hereditary night blindness. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include signal transducer activity and GTPase activator activity. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot for RGS11 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form

Gene Wiki entry for RGS11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS11 Gene

Genomics for RGS11 Gene

Regulatory Elements for RGS11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGS11 Gene

Start:
268,301 bp from pter
End:
275,980 bp from pter
Size:
7,680 bases
Orientation:
Minus strand

Genomic View for RGS11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS11 Gene

Proteins for RGS11 Gene

  • Protein details for RGS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94810-RGS11_HUMAN
    Recommended name:
    Regulator of G-protein signaling 11
    Protein Accession:
    O94810
    Secondary Accessions:
    • O75883
    • Q4TT71
    • Q4TT72

    Protein attributes for RGS11 Gene

    Size:
    467 amino acids
    Molecular mass:
    52946 Da
    Quaternary structure:
    • Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).

    Alternative splice isoforms for RGS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS11 Gene

Proteomics data for RGS11 Gene at MOPED

Post-translational modifications for RGS11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS11 Gene

No data available for DME Specific Peptides for RGS11 Gene

Domains for RGS11 Gene

Gene Families for RGS11 Gene

HGNC:
  • RGS :Regulators of G-protein signaling

Graphical View of Domain Structure for InterPro Entry

O94810

UniProtKB/Swiss-Prot:

RGS11_HUMAN :
  • O94810
Domain:
  • Contains 1 DEP domain.
  • Contains 1 G protein gamma domain.
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS11: view

Function for RGS11 Gene

Molecular function for RGS11 Gene

GENATLAS Biochemistry: negative regulator of G protein signaling 11,predominantly expressed in both brain and retina,functioning as GTPase-activating protein for G protein alpha subunits,G alpha i, G alpha o and complexing with G beta 5
UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form

Gene Ontology (GO) - Molecular Function for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005096 GTPase activator activity IBA --
GO:0031681 G-protein beta-subunit binding IPI 12606627
genes like me logo Genes that share ontologies with RGS11: view

Phenotypes for RGS11 Gene

genes like me logo Genes that share phenotypes with RGS11: view

Animal Models for RGS11 Gene

MGI Knock Outs for RGS11:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RGS11 Gene

Localization for RGS11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS11 Gene COMPARTMENTS Subcellular localization image for RGS11 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005886 plasma membrane IBA --
GO:0043234 protein complex IDA 18468998
GO:0044292 dendrite terminus IEA --
genes like me logo Genes that share ontologies with RGS11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGS11 Gene

Pathways for RGS11 Gene

genes like me logo Genes that share pathways with RGS11: view

Pathways by source for RGS11 Gene

Gene Ontology (GO) - Biological Process for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 9789084
GO:0035556 intracellular signal transduction IEA --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity TAS 9789084
genes like me logo Genes that share ontologies with RGS11: view

Transcripts for RGS11 Gene

Unigene Clusters for RGS11 Gene

Regulator of G-protein signaling 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RGS11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for RGS11 Gene

GeneLoc Exon Structure for
RGS11
ECgene alternative splicing isoforms for
RGS11

Expression for RGS11 Gene

mRNA expression in normal human tissues for RGS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS11 Gene

This gene is overexpressed in Brain - Cerebellum (8.3) and Brain - Cerebellar Hemisphere (6.8).

SOURCE GeneReport for Unigene cluster for RGS11 Gene Hs.65756

genes like me logo Genes that share expressions with RGS11: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for RGS11 Gene

Orthologs for RGS11 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS11 35
  • 93.76 (n)
  • 91.69 (a)
RGS11 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS11 35
  • 83.88 (n)
  • 80.26 (a)
RGS11 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS11 35
  • 81.32 (n)
  • 77.14 (a)
RGS11 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs11 35
  • 81.89 (n)
  • 79.96 (a)
Rgs11 16
Rgs11 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS11 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS11 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs11 35
  • 82.59 (n)
  • 80.8 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 68 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
RGS11 35
  • 75.68 (n)
  • 72.07 (a)
lizard
(Anolis carolinensis)
Reptilia RGS11 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs9 35
  • 69.66 (n)
  • 68.89 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs11 35
  • 65.49 (n)
  • 61.65 (a)
rgs11 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000232 35
  • 54.56 (n)
  • 42.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42450 36
  • 14 (a)
OneToMany
CG7095 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea eat-16 36
  • 30 (a)
ManyToMany
Species with no ortholog for RGS11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS11 Gene

ENSEMBL:
Gene Tree for RGS11 (if available)
TreeFam:
Gene Tree for RGS11 (if available)

Paralogs for RGS11 Gene

Paralogs for RGS11 Gene

genes like me logo Genes that share paralogs with RGS11: view

Variants for RGS11 Gene

Sequence variations from dbSNP and Humsavar for RGS11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs403228 -- 277,699(-) GAGAT(C/T)GCGCC upstream-variant-2KB
rs2685125 -- 274,403(-) TCTCT(C/G)GGTGG intron-variant
rs2685126 -- 274,052(-) GTGGA(C/T)TATGA synonymous-codon, reference, utr-variant-5-prime, nc-transcript-variant
rs2857999 -- 277,015(+) atgcc(C/T)cagcc upstream-variant-2KB
rs3743880 -- 276,027(+) CGGTT(C/T)GGGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RGS11 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2458n71 CNV Loss 21882294
nsv904652 CNV Loss 21882294
dgv32n68 CNV Loss 17160897
dgv2465n71 CNV Loss 21882294
dgv2466n71 CNV Loss 21882294
nsv904674 CNV Loss 21882294
nsv827477 CNV Gain 20364138
dgv2467n71 CNV Loss 21882294
nsv904677 CNV Loss 21882294
dgv2468n71 CNV Loss 21882294
dgv2469n71 CNV Loss 21882294
dgv2470n71 CNV Loss 21882294
nsv904690 CNV Loss 21882294

Relevant External Links for RGS11 Gene

HapMap Linkage Disequilibrium report
RGS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS11 Gene

Disorders for RGS11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RGS11 Gene including...

Search for RGS11 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RGS11 Gene

Relevant External Links for RGS11

Genetic Association Database (GAD)
RGS11
Human Genome Epidemiology (HuGE) Navigator
RGS11
genes like me logo Genes that share disorders with RGS11: view

No data available for UniProtKB/Swiss-Prot for RGS11 Gene

Publications for RGS11 Gene

  1. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. (PMID: 9789084) Snow B.E. … Siderovski D.P. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. (PMID: 10339615) Snow B.E. … Siderovski D.P. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 48

Products for RGS11 Gene

  • Addgene plasmids for RGS11

Sources for RGS11 Gene

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