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Aliases for RGS10 Gene

Aliases for RGS10 Gene

  • Regulator Of G Protein Signaling 10 2 3 5
  • Regulator Of G-Protein Signalling 10 2
  • Regulator Of G-Protein Signaling 10 2

External Ids for RGS10 Gene

Previous GeneCards Identifiers for RGS10 Gene

  • GC10M120178
  • GC10M120503
  • GC10M121390
  • GC10M120924
  • GC10M121249
  • GC10M114886

Summaries for RGS10 Gene

Entrez Gene Summary for RGS10 Gene

  • Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS10 Gene

RGS10 (Regulator Of G Protein Signaling 10) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot for RGS10 Gene

  • Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).

Gene Wiki entry for RGS10 Gene

Additional gene information for RGS10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS10 Gene

Genomics for RGS10 Gene

GeneHancer (GH) Regulatory Elements for RGS10 Gene

Promoters and enhancers for RGS10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I119540 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 556.1 0.0 -15 3.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZNF207 ZNF143 ZNF263 RGS10 ENSG00000271353
GH10I119535 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 556.1 +6.4 6448 1.4 PRDM6 POLR2A ZBTB21 ZNF629 ATF7 ATF2 ZBTB17 RGS10 GC10P119418
GH10I119515 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +24.7 24748 5.4 HDGF IRF4 TCF12 ATF7 RUNX3 ZNF263 CAVIN1 JUNB REST ZNF592 RGS10 TIAL1 EIF3A GC10P119418
GH10I119267 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +271.0 270968 8.8 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 FOS DEK SP5 RGS10 GRK5 SFXN4 EIF3A GC10P119246 LOC105378511
GH10I119498 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.6 +41.6 41557 5.6 ELF3 FOXA2 MLX ARID4B RAD21 THRB RARA IKZF2 RUNX3 MIXL1 RGS10 TIAL1 GC10P119418
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGS10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS10 gene promoter:

Genomic Locations for RGS10 Gene

Genomic Locations for RGS10 Gene
chr10:119,499,827-119,542,710
(GRCh38/hg38)
Size:
42,884 bases
Orientation:
Minus strand
chr10:121,259,339-121,302,222
(GRCh37/hg19)

Genomic View for RGS10 Gene

Genes around RGS10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS10 Gene

Proteins for RGS10 Gene

  • Protein details for RGS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43665-RGS10_HUMAN
    Recommended name:
    Regulator of G-protein signaling 10
    Protein Accession:
    O43665
    Secondary Accessions:
    • A8K408
    • B1AMR8
    • Q6IAZ6
    • Q96GN0

    Protein attributes for RGS10 Gene

    Size:
    173 amino acids
    Molecular mass:
    20236 Da
    Quaternary structure:
    • Interacts with GNAZ, GNAI1 and GNAI3 (PubMed:8774883, PubMed:11443111, PubMed:18434541). Associates specifically with the activated, GTP-bound forms of GNAZ and GNAI3 (PubMed:8774883).

    Three dimensional structures from OCA and Proteopedia for RGS10 Gene

    Alternative splice isoforms for RGS10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS10 Gene

Post-translational modifications for RGS10 Gene

Other Protein References for RGS10 Gene

No data available for DME Specific Peptides for RGS10 Gene

Domains & Families for RGS10 Gene

Gene Families for RGS10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS10 Gene

Suggested Antigen Peptide Sequences for RGS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS10: view

No data available for UniProtKB/Swiss-Prot for RGS10 Gene

Function for RGS10 Gene

Molecular function for RGS10 Gene

UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).

Phenotypes From GWAS Catalog for RGS10 Gene

Gene Ontology (GO) - Molecular Function for RGS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IPI 18434541
GO:0005096 GTPase activator activity IEA,IDA 11443111
genes like me logo Genes that share ontologies with RGS10: view
genes like me logo Genes that share phenotypes with RGS10: view

Animal Models for RGS10 Gene

MGI Knock Outs for RGS10:

Animal Model Products

miRNA for RGS10 Gene

miRTarBase miRNAs that target RGS10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS10 Gene

Localization for RGS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS10 Gene

Cytoplasm, cytosol. Nucleus. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus. {ECO:0000269 PubMed:11443111}.
Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS10 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10791963
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 11443111
GO:0005886 plasma membrane IBA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with RGS10: view

Pathways & Interactions for RGS10 Gene

genes like me logo Genes that share pathways with RGS10: view

SIGNOR curated interactions for RGS10 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RGS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway IDA 11443111
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IDA 18434541
genes like me logo Genes that share ontologies with RGS10: view

Drugs & Compounds for RGS10 Gene

(3) Drugs for RGS10 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCG-63802 Pharma RGS protein inhibitor 0
CCG-63808 Pharma Reversible RGS inhibitor 0

(1) Additional Compounds for RGS10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for RGS10 Gene

Compound Action Cas Number
CCG-63802 RGS protein inhibitor 620112-78-9
CCG-63808 Reversible RGS inhibitor 620113-73-7
genes like me logo Genes that share compounds with RGS10: view

Drug Products

Transcripts for RGS10 Gene

Unigene Clusters for RGS10 Gene

Regulator of G-protein signaling 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for RGS10 Gene

GeneLoc Exon Structure for
RGS10
ECgene alternative splicing isoforms for
RGS10

Expression for RGS10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS10 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for RGS10 Gene

This gene is overexpressed in Tlymphocyte (19.6), Peripheral blood mononuclear cells (14.5), Lymph node (7.3), and Platelet (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RGS10 Gene



Protein tissue co-expression partners for RGS10 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS10 Gene:

RGS10

SOURCE GeneReport for Unigene cluster for RGS10 Gene:

Hs.501200

Evidence on tissue expression from TISSUES for RGS10 Gene

  • Liver(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with RGS10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS10 Gene

Orthologs for RGS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS10 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia RGS10 33 34
  • 92.48 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS10 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS10 33 34
  • 91.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RGS10 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs10 33
  • 88.4 (n)
mouse
(Mus musculus)
Mammalia Rgs10 33 16 34
  • 87.48 (n)
chicken
(Gallus gallus)
Aves RGS10 34 33
  • 78.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS10 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs10 33
  • 67.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15644 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-196h16.12 34
  • 30 (a)
ManyToMany
si:ch211-117l17.6 34
  • 23 (a)
ManyToMany
si:ch211-152p11.4 34
  • 14 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta loco 34
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-7 34
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8856 34
ManyToMany
Species where no ortholog for RGS10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS10 Gene

ENSEMBL:
Gene Tree for RGS10 (if available)
TreeFam:
Gene Tree for RGS10 (if available)

Paralogs for RGS10 Gene

Paralogs for RGS10 Gene

(20) SIMAP similar genes for RGS10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RGS10 Gene

genes like me logo Genes that share paralogs with RGS10: view

Variants for RGS10 Gene

Sequence variations from dbSNP and Humsavar for RGS10 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000089163 -- 119,524,350(-) A/G intron_variant
rs1000101707 -- 119,538,730(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000163449 -- 119,525,625(-) C/T intron_variant
rs1000208429 -- 119,513,787(-) G/A intron_variant
rs1000239533 -- 119,513,517(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS10 Gene

Variant ID Type Subtype PubMed ID
esv2741873 CNV deletion 23290073
esv2741884 CNV deletion 23290073
esv3624706 CNV gain 21293372
nsv1044497 CNV gain 25217958
nsv552215 CNV loss 21841781
nsv7570 CNV insertion 18451855
nsv832007 CNV gain 17160897

Variation tolerance for RGS10 Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 36.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS10 Gene

Disorders for RGS10 Gene

Additional Disease Information for RGS10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGS10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS10 Gene

Publications for RGS10 Gene

  1. Novel missense polymorphism in the regulator of G-protein signaling 10 gene: analysis of association with schizophrenia. (PMID: 15482592) Hishimoto A … Maeda K (Psychiatry and clinical neurosciences 2004) 3 22 44 58
  2. Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). (PMID: 11443111) Burgon PG … Casey PJ (The Journal of biological chemistry 2001) 3 4 22 58
  3. Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. (PMID: 10608901) Tu Y … Ross EM (The Journal of biological chemistry 1999) 3 4 22 58
  4. Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits. (PMID: 9353196) Tu Y … Ross EM (Science (New York, N.Y.) 1997) 3 4 22 58
  5. RGS10 is a selective activator of G alpha i GTPase activity. (PMID: 8774883) Hunt TW … Peralta EG (Nature 1996) 2 3 4 58

Products for RGS10 Gene

Sources for RGS10 Gene

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