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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS10 Gene

protein-coding   GIFtS: 60
GCID: GC10M121249

Regulator Of G-Protein Signaling 10

(Previous name: regulator of G-protein signalling 10)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 101 2
Regulator Of G-Protein Signalling 101 2

External Ids:    HGNC: 99921   Entrez Gene: 60012   Ensembl: ENSG000001489087   OMIM: 6028565   UniProtKB: O436653   

Export aliases for RGS10 gene to outside databases

Previous GC identifers: GC10M120178 GC10M120503 GC10M121390 GC10M120924 GC10M114886


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS10 Gene:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating
proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein
subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound
forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino
acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two
related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally
distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS10 Gene: 
RGS10 (regulator of G-protein signaling 10) is a protein-coding gene. Diseases associated with RGS10 include anorexia nervosa, and schizophrenia, and among its related super-pathways are G-AlphaQ Signaling and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS14.

UniProtKB/Swiss-Prot: RGS10_HUMAN, O43665
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G
protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct
G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein

Gene Wiki entry for RGS10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS10 gene promoter:
         MEF-2A   MZF-1   aMEF-2   AP-2gamma   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS10 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q25

RGS10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS10 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M121249:  view genomic region     (about GC identifiers)

Start:
121,259,339 bp from pter      End:
121,302,222 bp from pter
Size:
42,884 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGS10_HUMAN, O43665 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 10  
Size: 173 amino acids; 20236 Da
3 PDB 3D structures from and Proteopedia for RGS10:
2DLR (3D)        2I59 (3D)        2IHB (3D)    
Secondary accessions: A8K408 B1AMR8 Q6IAZ6 Q96GN0
Alternative splicing: 3 isoforms:  O43665-1   O43665-2   O43665-3   

Explore the universe of human proteins at neXtProt for RGS10: NX_O43665

Explore proteomics data for RGS10 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 3 is phosphorylated on Ser-16
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43665

  • RGS10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGS10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005339.1  NP_002916.1  

    ENSEMBL proteins: 
     ENSP00000358097   ENSP00000358099   ENSP00000376605  

    Human Recombinant Protein Products for RGS10: 
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    Novus Biologicals RGS10 Proteins
    Novus Biologicals RGS10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RGS10
    Cloud-Clone Corp. Proteins for RGS10 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--
    GO:0043025neuronal cell body IEA--

    RGS10 for ontologies           About GeneDecksing



    RGS10 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry O43665

    ProtoNet protein and cluster: O43665

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS10_HUMAN, O43665
    Similarity: Contains 1 RGS domain


    RGS10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS10_HUMAN, O43665
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G
    protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct
    G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005515protein binding ----
         
    RGS10 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rgs10):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  skeleton 

    RGS10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rgs10tm1Ypl for RGS10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGS10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGS10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RGS10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RGS10 

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    hsa-miR-4324 hsa-miR-199a-5p hsa-miR-544b hsa-miR-199b-5p hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidRGS10 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGS10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    3Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    4G-protein signaling G-Protein alpha-i signaling cascades
    G-protein signaling G-Protein alpha-i signaling cascades0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RGS10
        G-protein signaling G-Protein alpha-i signaling cascades

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS10
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    1 GeneGo (Thomson Reuters) Pathway for RGS10
        G-protein signaling G-Protein alpha-i signaling cascades

    2 BioSystems Pathways for RGS10
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell



    RGS10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RGS10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/142 Interacting proteins for RGS10 (O436653 ENSP000003580994) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    SAP18O004223, ENSP000003719734I2D: score=2 STRING: ENSP00000371973
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity IBA--

    RGS10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS10

    2 Novoseek inferred chemical compound relationships for RGS10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 26.8 4 11897687 (4)
    cysteine 12 1 10608901 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGS10 gene (2 alternative transcripts): 
    NM_001005339.1  NM_002925.3  

    Unigene Cluster for RGS10:

    Regulator of G-protein signaling 10
    Hs.501200  [show with all ESTs]
    Unigene Representative Sequence: BU587578
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369101 ENST00000369103(uc001leg.3) ENST00000469575 ENST00000473563
    ENST00000392865(uc001lee.3 uc001lef.3)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS10:
    hsa-miR-4324 hsa-miR-199a-5p hsa-miR-544b hsa-miR-199b-5p hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidRGS10 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS10

    Additional mRNA sequence: 

    AF368902.1 AF493934.1 AK290773.1 BC009361.2 CR457008.1 

    8 DOTS entries:

    DT.316595  DT.100790042  DT.100025269  DT.91700497  DT.91700474  DT.91700505  DT.95174542  DT.97843216 

    24/157 AceView cDNA sequences (see all 157):

    AA256075 AI131395 AI141762 AA736855 BM841078 AA286962 BM930359 AA969474 
    BM914667 AW016641 BC009361 AI186408 BQ890645 CB529515 AI344720 AI383353 
    H50312 CR592645 AI217605 AI089099 AA482391 AA917840 AI276520 AI276790 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RGS10    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -     -                             -               
    SP2:              -                             -               
    SP3:                                      -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for RGS10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS10 expression in normal human tissues (normalized intensities)      RGS10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCTAAGC
    RGS10 Expression
    About this image


    RGS10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             platelets   
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

    See RGS10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS10

    SOURCE GeneReport for Unigene cluster: Hs.501200
        SABiosciences Custom PCR Arrays for RGS10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RGS10 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs101 , 5 regulator of G-protein signalling 101, 5 87.48(n)1
    92.27(a)1
      7 (70.16 cM)5
    678651  NM_026418.21  NP_080694.11 
     1283736215 
    chicken
    (Gallus gallus)
    Aves RGS101 regulator of G-protein signaling 10 77.37(n)
    83.64(a)
      423930  XM_421790.3  XP_421790.3 
    lizard
    (Anolis carolinensis)
    Reptilia RGS106
    Uncharacterized protein
    75(a)
    1 ↔ 1
    3(66417728-66432073)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.156442 Xenopus laevis transcribed sequence with weak similarity more 79.48(n)    BJ061877.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta loco6
    locomotion defects
    4(a)
    1 → many
    3R(18445690-18465082)
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-46
    Protein RGS-4, isoform a
    17(a)
    possible ortholog
    II(12667698-12671623)


    ENSEMBL Gene Tree for RGS10 (if available)
    TreeFam Gene Tree for RGS10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS10 gene
    RGS142  RGS112  RGS122  RGS72  RGS62  RGS92  
    18/20 SIMAP similar genes for RGS10 using alignment to 1 protein entry:     RGS10_HUMAN(see all similar genes):
    RGS17    RGS9    RGS20    RGS4    RGS12    RGS5
    RGS19    RGS3    RGS1    RGS2    RGS6    RGS7
    RGS16    AXIN2    DKFZp781B0869    RGS8    RGS11    RGS13

    RGS10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RGS10
    PGOHUM00000249713


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/933 SNPs in RGS10 are shown (see all 933)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923826241,2
    --121258840(+) CCGATA/GGGTAC 2 -- ds50010--------
    rs1129062451,2
    C,F--121258885(+) AGTACG/ACACCT 2 -- ds50012Minor allele frequency- A:0.02NA 122
    rs793086811,2
    C,F--121258925(+) AGTTGC/TCATGG 2 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1485860581,2
    C--121258951(+) TCCCAC/TTTGTG 2 -- ds50010--------
    rs1839462441,2
    --121259144(+) TTTTTC/TCAGCA 2 -- ds50010--------
    rs1135997311,2
    F--121259235(+) ACTCAC/TGTTTG 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1929534681,2
    --121259271(+) ACATGA/CGTCCA 2 -- ds50010--------
    rs761299521,2
    C,F--121259383(+) ACGTGT/ACCAGT 2 -- ut311Minor allele frequency- A:0.01WA 118
    rs746160921,2
    C,F--121259464(+) CCATCA/TTGCAA 2 -- ut311Minor allele frequency- T:0.04WA 118
    rs1848625361,2
    --121259566(+) CGGCAA/CGGTCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RGS10 (121259339 - 121302222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RGS10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2741884CNV Deletion23290073
    esv2741873CNV Deletion23290073
    nsv7570CNV Insertion18451855
    nsv832007CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602856    OMIM disorders: --

    12 diseases for RGS10:    About MalaCards
    anorexia nervosa    schizophrenia    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    parkinson's disease    colon cancer    retinitis    alzheimer's disease
    ovarian cancer    squamous cell carcinoma    gastric cancer    neuronitis


    RGS10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for RGS10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 8.3 2 15482592 (2)

    Genetic Association Database (GAD): RGS10
    Human Genome Epidemiology (HuGE) Navigator: RGS10 (4 documents)

    Export disorders for RGS10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS10 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with RGS10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RGS10 is a selective activator of G alpha i GTPase activity. (PubMed id 8774883)1, 2, 3 Hunt T.W.... Peralta E.G. (1996)
    2. Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10. (PubMed id 10608901)1, 2, 9 Tu Y.... Ross E.M. (1999)
    3. Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). (PubMed id 11443111)1, 2, 9 Burgon P.G....Casey P.J. (2001)
    4. Novel missense polymorphism in the regulator of G-protein signaling 10 gene: analysis of association with schizophrenia. (PubMed id 15482592)1, 4, 9 Hishimoto A....Maeda K. (2004)
    5. Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits. (PubMed id 9353196)1, 2, 9 Tu Y.... Ross E.M. (1997)
    6. Genetic variations in regulator of G-protein signalin g genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (2010)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    9. Cytoplasmic, nuclear, and Golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. (PubMed id 10791963)1, 2 Chatterjee T.K. and Fisher R.A. (2000)
    10. Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3. (PubMed id 16511171)1, 9 Lee H.K....Kim E.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6001 HGNC: 9992 AceView: RGS10 Ensembl:ENSG00000148908 euGenes: HUgn6001
    ECgene: RGS10 H-InvDB: RGS10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGS10 gene:
    Search GeneIP for patents involving RGS10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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