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Aliases for RGS10 Gene

Aliases for RGS10 Gene

  • Regulator Of G-Protein Signaling 10 2 3
  • Regulator Of G-Protein Signalling 10 2

External Ids for RGS10 Gene

Previous GeneCards Identifiers for RGS10 Gene

  • GC10M120178
  • GC10M120503
  • GC10M121390
  • GC10M120924
  • GC10M121249
  • GC10M114886

Summaries for RGS10 Gene

Entrez Gene Summary for RGS10 Gene

  • Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS10 Gene

RGS10 (Regulator Of G-Protein Signaling 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot for RGS10 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein

Gene Wiki entry for RGS10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS10 Gene

Genomics for RGS10 Gene

Regulatory Elements for RGS10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RGS10 Gene

Chromosome:
10
Start:
119,499,827 bp from pter
End:
119,542,710 bp from pter
Size:
42,884 bases
Orientation:
Minus strand

Genomic View for RGS10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS10 Gene

Proteins for RGS10 Gene

  • Protein details for RGS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43665-RGS10_HUMAN
    Recommended name:
    Regulator of G-protein signaling 10
    Protein Accession:
    O43665
    Secondary Accessions:
    • A8K408
    • B1AMR8
    • Q6IAZ6
    • Q96GN0

    Protein attributes for RGS10 Gene

    Size:
    173 amino acids
    Molecular mass:
    20236 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS10 Gene

    Alternative splice isoforms for RGS10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS10 Gene

Proteomics data for RGS10 Gene at MOPED

Post-translational modifications for RGS10 Gene

Other Protein References for RGS10 Gene

Antibody Products

No data available for DME Specific Peptides for RGS10 Gene

Domains & Families for RGS10 Gene

Gene Families for RGS10 Gene

Protein Domains for RGS10 Gene

Suggested Antigen Peptide Sequences for RGS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43665

UniProtKB/Swiss-Prot:

RGS10_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS10: view

Function for RGS10 Gene

Molecular function for RGS10 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein

Gene Ontology (GO) - Molecular Function for RGS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGS10: view
genes like me logo Genes that share phenotypes with RGS10: view

Animal Models for RGS10 Gene

MGI Knock Outs for RGS10:

Animal Model Products

miRNA for RGS10 Gene

miRTarBase miRNAs that target RGS10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RGS10 Gene

Localization for RGS10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS10 Gene COMPARTMENTS Subcellular localization image for RGS10 gene
Compartment Confidence
nucleus 4
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for RGS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10791963
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGS10 Gene

Pathways & Interactions for RGS10 Gene

genes like me logo Genes that share pathways with RGS10: view

Pathways by source for RGS10 Gene

SIGNOR curated interactions for RGS10 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RGS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009968 negative regulation of signal transduction IEA --
GO:0038032 termination of G-protein coupled receptor signaling pathway --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RGS10: view

Drugs & Compounds for RGS10 Gene

(1) Drugs for RGS10 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cysteine Nutra 143

(1) Additional Compounds for RGS10 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GnRH
genes like me logo Genes that share compounds with RGS10: view

Transcripts for RGS10 Gene

Unigene Clusters for RGS10 Gene

Regulator of G-protein signaling 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for RGS10 Gene

GeneLoc Exon Structure for
RGS10
ECgene alternative splicing isoforms for
RGS10

Expression for RGS10 Gene

mRNA expression in normal human tissues for RGS10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS10 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for RGS10 Gene

This gene is overexpressed in Tlymphocyte (19.6), Peripheral blood mononuclear cells (14.5), Lymph node (7.3), and Platelet (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGS10 Gene



SOURCE GeneReport for Unigene cluster for RGS10 Gene Hs.501200

genes like me logo Genes that share expression patterns with RGS10: view

Protein tissue co-expression partners for RGS10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RGS10 Gene

Orthologs for RGS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS10 35
  • 91.9 (n)
  • 95.58 (a)
RGS10 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS10 35
  • 92.48 (n)
  • 95.73 (a)
RGS10 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs10 35
  • 87.48 (n)
  • 92.27 (a)
Rgs10 16
Rgs10 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS10 35
  • 99.8 (n)
  • 99.39 (a)
RGS10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs10 35
  • 88.4 (n)
  • 93.92 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS10 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS10 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS10 35
  • 78.23 (n)
  • 86.39 (a)
RGS10 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS10 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs10 35
  • 67.03 (n)
  • 68.51 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15644 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-117l17.6 36
  • 23 (a)
ManyToMany
si:ch211-152p11.4 36
  • 14 (a)
ManyToMany
si:ch211-196h16.12 36
  • 30 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta loco 36
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-7 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8856 36
ManyToMany
Species with no ortholog for RGS10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS10 Gene

ENSEMBL:
Gene Tree for RGS10 (if available)
TreeFam:
Gene Tree for RGS10 (if available)

Paralogs for RGS10 Gene

Paralogs for RGS10 Gene

(20) SIMAP similar genes for RGS10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RGS10 Gene

genes like me logo Genes that share paralogs with RGS10: view

Variants for RGS10 Gene

Sequence variations from dbSNP and Humsavar for RGS10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs139556525 -- 119,538,846(+) GAAAC(C/T)TGGGG intron-variant
rs139682525 -- 119,542,653(+) CGCCC(A/G)AGGAG utr-variant-5-prime
rs139703950 -- 119,506,033(+) ATTGC(A/G)GCTCT intron-variant
rs139771747 -- 119,542,140(+) CCCAG(C/G)CCCAG intron-variant
rs139802534 -- 119,521,628(+) AAAGA(-/AAGGAAGG)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS10 Gene

Variant ID Type Subtype PubMed ID
nsv832007 CNV Gain 17160897
esv2741873 CNV Deletion 23290073
esv2741884 CNV Deletion 23290073
nsv7570 CNV Insertion 18451855

Variation tolerance for RGS10 Gene

Residual Variation Intolerance Score: 53.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 36.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS10 Gene

HapMap Linkage Disequilibrium report
RGS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS10 Gene

Disorders for RGS10 Gene

Relevant External Links for RGS10

Genetic Association Database (GAD)
RGS10
Human Genome Epidemiology (HuGE) Navigator
RGS10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS10
genes like me logo Genes that share disorders with RGS10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS10 Gene

Publications for RGS10 Gene

  1. Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. (PMID: 19913097) Tansey M.G. … Goldberg M.S. (Neurobiol. Dis. 2010) 23 67
  2. PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. (PMID: 18992738) Lu J. … Chen K.Y. (Eur. J. Pharmacol. 2008) 23 67
  3. Resonance assignment of the RGS domain of human RGS10. (PMID: 17180548) Fedorov O.Y. … Ball L.J. (J. Biomol. NMR 2007) 23 67
  4. Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins. (PMID: 16441551) Rimler A. … Zisapel N. (J. Pineal Res. 2006) 23 67
  5. Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation. (PMID: 16489565) Appleton C.T. … Beier F. (J. Cell. Physiol. 2006) 23 67

Products for RGS10 Gene

Sources for RGS10 Gene

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