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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RGS1 Gene

protein-coding GIFtS: 59
GCID: GC01P192544

regulator of G-protein signaling 1

(Previous name: regulator of G-protein signalling 1 )
(Previous symbol: IER1)

Explore 19 diseases affiliated with
RGS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 1¹ ²		Regulator Of G-Protein Signalling 1¹ ²
IER1¹ ² ³ ⁵		Early Response Protein 1R20² ³
1R20¹ ² ³		B-Cell Activation Protein BL34² ³
BL34¹ ² ³		Immediate-Early Response 1, B-Cell Specific²
IR20¹ ² ⁵

External Ids:	HGNC: 9991¹	Entrez Gene: 5996²	Ensembl: ENSG00000090104⁷	OMIM: 600323⁵	UniProtKB: Q08116³

Export aliases for RGS1 gene to outside databases

Previous GC identifers: GC01P190335 GC01P188059 GC01P189011 GC01P189833 GC01P189276 GC01P190811 GC01P163781

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS1:

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic

side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein

attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a

GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G

alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby

terminating the signal. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and

proliferation

Gene Wiki entry for RGS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RGS1 gene promoter:
TBP Nkx2-5 IRF-1 Nkx5-1 E47 TFIID STAT3 Hand1 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RGS1 promoter sequence

Search SABiosciences Chromatin IP Primers for RGS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31 Ensembl cytogenetic band: 1q31.2 HGNC cytogenetic band: 1q31

RGS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P192544: view genomic region (about GC identifiers)

Start:	192,544,857 bp from pter	End:	192,549,161 bp from pter
Size:	4,305 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116 (See protein sequence)

Recommended Name: Regulator of G-protein signaling 1

Size: 209 amino acids; 23858 Da

Sequence caution: Sequence=AAB26289.1; Type=Erroneous initiation; Sequence=AAH15510.1; Type=Erroneous initiation;

Sequence=BAG37976.1; Type=Erroneous initiation; Sequence=BAG64242.1; Type=Erroneous initiation; Sequence=CAA51826.1;

Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for RGS1:

2BV1 (3D)

2GTP (3D)

Secondary accessions: B2RDM9 B4DZY0 Q07918 Q9H1W2

Alternative splicing: 2 isoforms: Q08116-1 Q08116-2

Explore the universe of human proteins at neXtProt for RGS1: NX_Q08116

Post-translational modifications:

Could be phosphorylated. Might be functionally regulated by protein kinase(s)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q08116

RGS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002913.3

ENSEMBL proteins:

ENSP00000356429 ENSP00000464323

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for RGS1
	Uscn Proteins for RGS1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IBA	--
GO:0005886	plasma membrane	IBA	--

RGS1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RGS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RGS1 for domains About GeneDecksing

3 InterPro domains/families:

IPR024066 Regulat_G_prot_signal_dom1

IPR000342 Regulat_G_prot_signal

IPR016137 Regulat_G_prot_signal_superfam

Graphical View of Domain Structure for InterPro Entry Q08116

ProtoNet protein and cluster: Q08116

1 Blocks protein family: IPB000342 Regulator of G-protein signalling (RGS) protein signature

UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116

Similarity: Contains 1 RGS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving

them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and

proliferation

Induction: In response to several B-cell activation signals

Genatlas biochemistry entry for RGS1:

negative regulator of G-protein signaling 1,23kDa,functioning as GTPase-activating protein for G protein alpha

subunits,G alpha i and G alpha o,abundantly expressed in B cells,C elegans EGL-10 and yeast SST2 homolog

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		hsa-miR-374c hsa-miR-223 hsa-miR-655 hsa-miR-1237 hsa-miR-27a hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: RGS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RGS1

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		Search LifeMap BioReagents cell lines for RGS1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IBA	--
GO:0005516	calmodulin binding	TAS	10747990

RGS1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Rgs1^tm1Jhk for RGS1
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rgs1):

hematopoietic system

immune system

RGS1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-AlphaQ Signaling

G-AlphaQ Signaling

1.00

G-AlphaI Signaling

0.47

Calcium Regulation in the Cardiac Cell

Calcium Regulation in the Cardiac Cell

1.00

Myometrial Relaxation and Contraction Pathways

0.43

Selected targets of CREB1

Selected targets of CREB1

1.00

CXCR4-mediated signaling events

CXCR4-mediated signaling events

1.00

Activation of cAMP-Dependent PKA

cAMP Pathway

0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RGS1

Selected targets of CREB1

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS1

	cAMP Pathway
	G-AlphaI Signaling
	G-AlphaQ Signaling

3 BioSystems Pathways for RGS1

	Myometrial Relaxation and Contraction Pathways
	Calcium Regulation in the Cardiac Cell
	CXCR4-mediated signaling events

1 PharmGKB Pathway for RGS1

Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

RGS1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RGS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/153 Interacting proteins for RGS1 (Q08116^{2, 3} ENSP00000356429⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 153)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FUNDC2	Q9BWH2²^,³, ENSP00000358510⁴	MINT-64062 I2D: score=5 STRING: ENSP00000358510
TSC22D1	Q15714²^,³	MINT-64060 I2D: score=5
UTP14A	Q9BVJ6²^,³	MINT-64061 I2D: score=5
MAP3K12	Q12852²^,³	MINT-64059 I2D: score=4
GNAO1	P09471³, ENSP00000262493⁴	I2D: score=1 STRING: ENSP00000262493

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	8241276
GO:0007165	signal transduction	NAS	8241276
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	TAS	10480894
GO:0038032	termination of G-protein coupled receptor signaling pathway	IEA	--
GO:0043547	positive regulation of GTPase activity	TAS	10747990

RGS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RGS1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RGS1
4 Novoseek chemical compound relationships for RGS1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	44	1	8774882 (1)
gtp	42.5	1	11520900 (1)
cycloheximide	32.4	1	9174164 (1)
calcium	0	2	9174164 (1), 9539105 (1)

Search CenterWatch for drugs/clinical trials and news about RGS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RGS1 gene:

NM_002922.3

Unigene Cluster for RGS1:

Regulator of G-protein signaling 1

Hs.75256 [show with all ESTs]

Unigene Representative Sequence: NM_002922

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367459(uc001gsi.1) ENST00000474373 ENST00000462589 ENST00000583155

ENST00000469578(uc010pou.1) ENST00000498352

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate RGS1:
		hsa-miR-374c hsa-miR-223 hsa-miR-655 hsa-miR-1237 hsa-miR-27a hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: RGS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: RGS1 (NM_002922)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGS1

Additional cDNA sequence:

AF493925.1 AK303138.1 AK315607.1 BC015510.1 BT006668.1 X73427.1

12 DOTS entries:

DT.92433858 DT.95275919 DT.316113 DT.91796220 DT.121383703 DT.40306067 DT.91919646 DT.92433847

DT.121383666 DT.100789138 DT.95275923 DT.92433856

24/203 AceView cDNA sequences (see all 203):

BU177934 BQ932968 BI771534 AI357954 AI301907 BG536972 BE351034 AA862337

AA570239 AW149027 CA395852 BQ008055 AU105990 BX282109 AW235917 BE349427

AI245011 AI673362 AA235545 BF105969 AI983062 AI339707 AA013313 AI912421

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RGS1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c
SP1:																					-
SP2:
SP3:																					-
SP4:											-		-		-		-				-
SP5:									-		-

ECgene alternative splicing isoforms for RGS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RGS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTTGCTAC

About this image

RGS1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RGS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGS1

SOURCE GeneReport for Unigene cluster: Hs.75256

UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116

Tissue specificity: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells;

however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is

constitutively high

SABiosciences Custom PCR Arrays for RGS1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RGS1 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RGS1¹	regulator of G-protein signaling 1	70.41(n) 66.33(a)		424360 XM_422203.3 XP_422203.3
lizard (Anolis carolinensis)	Reptilia	RGS1⁶	--	58(a)	1 ↔ 1	GL343267.1(1553249-1558641)
zebrafish (Danio rerio)	Actinopterygii	rgs13¹	regulator of G-protein signaling 13	58.52(n) 53.33(a)		100037359 NM_001089512.1 NP_001082981.1
worm (Caenorhabditis elegans)	Secernentea	rgs-7⁶ rgs-4⁶	Regulator of G-protein signaling rgs-7 Regulator of G protein Signaling family member (rg...	7(a) 19(a)	1 ↔ many possible ortholog	X(3542545-3557581) II(12667632-12671556)

ENSEMBL Gene Tree for RGS1 (if available)
TreeFam Gene Tree for RGS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RGS1 gene

RGS2² RGS8² RGS19² RGS21² RGS3² RGS16² RGS20² RGS5²

RGS17² RGS18² RGS4² RGS13²

17 SIMAP similar genes for RGS1 using alignment to 1 protein entry: RGS1_HUMAN:

RGS21 RGS8 RGS13 RGS18 RGS20 RGS4

RGS17 RGS5 RGS19 RGS16 RGS7 RGS10

RGS2 RGS6 RGS3 RGS9 RGS12

RGS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140600315^1,2		--	192542939(+)	`CAGTTA/GTAAAT`	1	--	us2k¹		0	--	--	--	--
rs10921199^1,2	F,A,H,	--	192542951(+)	`CTTGCG/ACTTCA`	1	--	us2k¹		5		NS EA WA	520
rs74130688^1,2	C,	--	192543002(+)	`TCAGAG/ACAGTT`	1	--	us2k¹		2		WA	120
rs188517867^1,2		--	192543134(+)	`AACAAA/GTTAGG`	1	--	us2k¹		0	--	--	--	--
rs6701795^1,2	C,F,A,H,	--	192543142(+)	`AGGAGT/CCCAAC`	1	--	us2k¹		5		NS EA WA	526
rs10921200^1,2	F,H,	--	192543180(+)	`TTTTTG/ACTGCT`	1	--	us2k¹		5		NS EA WA	532
rs144550089^1,2		--	192543406(+)	`TGTCAC/TCTGTC`	1	--	us2k¹		0	--	--	--	--
rs147398435^1,2		--	192543408(+)	`TCATCA/TGTCTT`	1	--	us2k¹		0	--	--	--	--
rs139633310^1,2		--	192543424(+)	`TTCATC/TGGTCT`	1	--	us2k¹		0	--	--	--	--
rs10921201^1,2	F,A,H,	--	192543428(+)	`TCGGTC/TTCATT`	1	--	us2k¹		5		NS EA WA	538

HapMap Linkage Disequilibrium report for RGS1 (192544857 - 192549161 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RGS1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RGS1 for disorders           About GeneDecksing

OMIM gene information: 600323    OMIM disorders: --

19 diseases for RGS1:    About MalaCards

b-cell non-hodgkin lymphoma non-hodgkin lymphoma hodgkin's lymphoma hairy cell leukemia

anorexia nervosa esophageal squamous cell carcinoma yaws squamous cell carcinoma

chronic lymphocytic leukemia multiple sclerosis lymphocytic leukemia celiac disease

t-cell leukemia leukemia esophagitis carcinoma

retinitis arthritis melanoma

Human Genome Epidemiology (HuGE) Navigator: RGS1 (15 documents)

Export disorders for RGS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RGS1 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with RGS1)

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A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. (PubMed id 8241276)^{1, 2, 3} Newton J.S.... Norton J.D. (1993)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PubMed id 8602223)^{1, 3} Druey K.M.... Kehrl J.H. (1996)
Isolation and characterization of a novel B cell activation gene. (PubMed id 8473738)^{1, 2} Hong J.X.... Kehrl J.H. (1993)
Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha. (PubMed id 11520900)^{1, 9} Hoffmann M....Milligan G. (2001)
Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells. (PubMed id 9174164)^{1, 9} Heximer S.P....Forsdyke D.R. (1997)
RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. (PubMed id 16565322)^{1, 9} Han J.I....Kehrl J.H. (2006)
CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells. (PubMed id 15728464)^{1, 9} Le Y....Silberstein L.E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5996	HGNC: 9991	AceView: RGS1	Ensembl:ENSG00000090104	euGenes: HUgn5996
ECgene: RGS1	H-InvDB: RGS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RGS1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RGS1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RGS1 gene
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Patent Information for RGS1 gene:
Search GeneIP for patents involving RGS1

GeneCards and IP:
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regulator of G-protein signaling 1

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regulator of G-protein signaling 1

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