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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RGS1 Gene

protein-coding   GIFtS: 61
GCID: GC01P192544

Regulator Of G-Protein Signaling 1

(Previous name: regulator of G-protein signalling 1)
(Previous symbol: IER1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Regulator Of G-Protein Signaling 11 2     BL342 3
IER11 2 3 5     B-Cell Activation Protein BL342 3
Regulator Of G-Protein Signalling 11 2     IR202 5
Early Response Protein 1R202 3     Immediate-Early Response 1, B-Cell Specific2
1R202 3     

External Ids:    HGNC: 99911   Entrez Gene: 59962   Ensembl: ENSG000000901047   OMIM: 6003235   UniProtKB: Q081163   

Export aliases for RGS1 gene to outside databases

Previous GC identifers: GC01P190335 GC01P188059 GC01P189011 GC01P189833 GC01P189276 GC01P190811 GC01P163781


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RGS1 Gene:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the
cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The
protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and
acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis
allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers,
thereby terminating the signal. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS1 Gene: 
RGS1 (regulator of G-protein signaling 1) is a protein-coding gene. Diseases associated with RGS1 include yaws, and hairy cell leukemia, and among its related super-pathways are G-AlphaQ Signaling and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell
activation and proliferation

Gene Wiki entry for RGS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RGS1 gene promoter:
         TBP   Nkx2-5   IRF-1   Nkx5-1   E47   TFIID   STAT3   Hand1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RGS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31

RGS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P192544:  view genomic region     (about GC identifiers)

Start:
192,544,857 bp from pter      End:
192,549,161 bp from pter
Size:
4,305 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 1  
Size: 209 amino acids; 23858 Da
Sequence caution: Sequence=AAB26289.1; Type=Erroneous initiation; Sequence=AAH15510.1; Type=Erroneous initiation;
Sequence=BAG37976.1; Type=Erroneous initiation; Sequence=BAG64242.1; Type=Erroneous initiation;
Sequence=CAA51826.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for RGS1:
2BV1 (3D)        2GTP (3D)    
Secondary accessions: B2RDM9 B4DZY0 Q07918 Q9H1W2
Alternative splicing: 2 isoforms:  Q08116-1   Q08116-2   

Explore the universe of human proteins at neXtProt for RGS1: NX_Q08116

Explore proteomics data for RGS1 at MOPED 

Post-translational modifications:

  • UniProtKB: Could be phosphorylated. Might be functionally regulated by protein kinase(s)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08116

  • RGS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RGS1 Protein Expression
    REFSEQ proteins: NP_002913.3  
    ENSEMBL proteins: 
     ENSP00000356429   ENSP00000464323  

    Human Recombinant Protein Products for RGS1: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RGS1
    Cloud-Clone Corp. Proteins for RGS1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--

    RGS1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR000342 Regulat_G_prot_signal
     IPR016137 Regulat_G_prot_signal_superfam

    Graphical View of Domain Structure for InterPro Entry Q08116

    ProtoNet protein and cluster: Q08116

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116
    Similarity: Contains 1 RGS domain


    RGS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS1_HUMAN, Q08116
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell
    activation and proliferation
    Induction: In response to several B-cell activation signals

         Genatlas biochemistry entry for RGS1:
    negative regulator of G-protein signaling 1,23kDa,functioning as GTPase-activating protein for G protein alpha
    subunits,G alpha i and G alpha o,abundantly expressed in B cells,C elegans EGL-10 and yeast SST2 homolog

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005516calmodulin binding TAS10747990
         
    RGS1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgs1):
     hematopoietic system  immune system 

    RGS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rgs1tm1Jhk for RGS1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RGS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RGS1

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    SwitchGear 3'UTR luciferase reporter plasmidRGS1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RGS1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    3Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    4Ca-dependent events
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RGS1
        Selected targets of CREB1

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RGS1
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    3 BioSystems Pathways for RGS1
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    CXCR4-mediated signaling events


    1 PharmGKB Pathway for RGS1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics


    RGS1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/153 Interacting proteins for RGS1 (Q081162, 3 ENSP000003564294) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUNDC2Q9BWH22, 3, ENSP000003585104MINT-64062 I2D: score=5 STRING: ENSP00000358510
    TSC22D1Q157142, 3MINT-64060 I2D: score=5 
    UTP14AQ9BVJ62, 3MINT-64061 I2D: score=5 
    MAP3K12Q128522, 3MINT-64059 I2D: score=4 
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS8241276
    GO:0007165signal transduction NAS8241276
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS10480894
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS10747990

    RGS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RGS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RGS1

    4 Novoseek inferred chemical compound relationships for RGS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 44 1 8774882 (1)
    gtp 42.5 1 11520900 (1)
    cycloheximide 32.4 1 9174164 (1)
    calcium 0 2 9174164 (1), 9539105 (1)

    Search CenterWatch for drugs/clinical trials and news about RGS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RGS1 gene: 
    NM_002922.3  

    Unigene Cluster for RGS1:

    Regulator of G-protein signaling 1
    Hs.75256  [show with all ESTs]
    Unigene Representative Sequence: NM_002922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367459(uc001gsi.1) ENST00000474373 ENST00000462589 ENST00000583155
    ENST00000469578(uc010pou.1) ENST00000498352
    miRNA
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    hsa-miR-374c hsa-miR-223 hsa-miR-655 hsa-miR-1237 hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidRGS1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF493925.1 AK303138.1 AK315607.1 BC015510.1 BT006668.1 X73427.1 

    12 DOTS entries:

    DT.92433858  DT.95275919  DT.316113  DT.91796220  DT.121383703  DT.40306067  DT.91919646  DT.92433847 
    DT.121383666  DT.100789138  DT.95275923  DT.92433856 

    24/203 AceView cDNA sequences (see all 203):

    AA013313 AW235917 F02574 CD244907 AU105990 AI912421 AA235545 AI298957 
    AI299219 BE220704 AK093544 BM894175 BI752145 BM998740 AA563873 BG536972 
    CA395852 BF105969 CA952507 AW612003 AI734842 AI860070 AA570239 AI708793 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RGS1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
    SP1:                                                              -                     
    SP2:                                                                                    
    SP3:                                                              -                     
    SP4:                                -     -     -     -           -                     
    SP5:                          -     -                                                   


    ECgene alternative splicing isoforms for RGS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RGS1 expression in normal human tissues (normalized intensities)      RGS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTGCTAC
    RGS1 Expression
    About this image


    RGS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 9 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived hematopoietic stem cells
             Peripheral blood Pan-T Cells   
             BONE MARROW   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Umbilical cord blood-derived hematopoietic stem cells
             Cord Blood CD133- Cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
             Pancreatic Islet   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived early endothelial progenitor cells
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus

    See RGS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RGS1

    SOURCE GeneReport for Unigene cluster: Hs.75256

    UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116
    Tissue specificity: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia
    B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia,
    expression is constitutively high

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RGS1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs11 , 5 regulator of G-protein signaling 11, 5 87.88(n)1
    86.6(a)1
      1 (62.56 cM)5
    507781  NM_015811.21  NP_056626.21 
     1442439725 
    chicken
    (Gallus gallus)
    Aves RGS11 regulator of G-protein signaling 1 70.41(n)
    66.33(a)
      424360  XM_422203.3  XP_422203.3 
    lizard
    (Anolis carolinensis)
    Reptilia RGS16
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL343267.1(1551717-1561081)
    zebrafish
    (Danio rerio)
    Actinopterygii rgs131 regulator of G-protein signaling 13 58.52(n)
    53.33(a)
      100037359  NM_001089512.1  NP_001082981.1 


    ENSEMBL Gene Tree for RGS1 (if available)
    TreeFam Gene Tree for RGS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RGS1 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS162  RGS172  
    RGS52  RGS182  RGS132  RGS42  
    17 SIMAP similar genes for RGS1 using alignment to 1 protein entry:     RGS1_HUMAN:
    RGS21    RGS8    RGS13    RGS18    RGS20    RGS4
    RGS17    RGS5    RGS19    RGS16    RGS7    RGS10
    RGS2    RGS6    RGS3    RGS9    RGS12

    RGS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/165 SNPs in RGS1 are shown (see all 165)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406003151,2
    --192542939(+) CAGTTA/GTAAAT 1 -- us2k10--------
    rs109211991,2
    C,F,A,H--192542951(+) CTTGCG/ACTTCA 1 -- us2k15Minor allele frequency- A:0.03NS EA WA 520
    rs741306881,2
    C,F--192543002(+) TCAGAG/ACAGTT 1 -- us2k12Minor allele frequency- A:0.21WA 120
    rs1885178671,2
    --192543134(+) AACAAA/GTTAGG 1 -- us2k10--------
    rs67017951,2
    C,F,A,H--192543142(+) AGGAGT/CCCAAC 1 -- us2k15Minor allele frequency- C:0.06NS EA WA 526
    rs109212001,2
    C,F,H--192543180(+) TTTTTG/ACTGCT 1 -- us2k15Minor allele frequency- A:0.04NS EA WA 532
    rs1445500891,2
    C--192543406(+) TGTCAC/TCTGTC 1 -- us2k10--------
    rs1473984351,2
    --192543408(+) TCATCA/TGTCTT 1 -- us2k10--------
    rs1396333101,2
    C--192543424(+) TTCATC/TGGTCT 1 -- us2k10--------
    rs109212011,2
    C,F,A,H--192543428(+) TCGGTC/TTCATT 1 -- us2k15Minor allele frequency- T:0.04NS EA WA 538

    HapMap Linkage Disequilibrium report for RGS1 (192544857 - 192549161 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RGS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3954CNV Insertion18451855
    nsv466994CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600323    OMIM disorders: --

    18 diseases for RGS1:    About MalaCards
    yaws    hairy cell leukemia    non-hodgkin lymphoma    hodgkin's lymphoma
    celiac disease    b-cell chronic lymphocytic leukemia    anorexia nervosa    esophageal squamous cell carcinoma
    t-cell leukemia    chronic lymphocytic leukemia    type 1 diabetes    multiple sclerosis
    esophagitis    squamous cell carcinoma    retinitis    leukemia
    melanoma    arthritis


    RGS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RGS1
    Human Genome Epidemiology (HuGE) Navigator: RGS1 (15 documents)

    Export disorders for RGS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RGS1 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with RGS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. (PubMed id 8241276)1, 2, 3 Newton J.S.... Norton J.D. (1993)
    2. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    3. Genetic variations in regulator of G-protein signalin g genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (2010)
    4. Four novel coeliac disease regions replicated in an a ssociation study of a Swedish-Norwegian family cohort. (PubMed id 19693089)1, 4 Amundsen S.S....Sollid L.M. (2010)
    5. Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. (PubMed id 20647273)1, 4 Hinks A....Thomson W. (2010)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Multiple sclerosis susceptibility alleles in African Americans. (PubMed id 19865102)1, 4 Johnson B.A....Oksenberg J.R. (2009)
    9. Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease. (PubMed id 18805825)1, 4 Romanos J....Wijmenga C. (2009)
    10. Integration of genetic risk factors into a clinical a lgorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PubMed id 19879194)1, 4 De Jager P.L.... E.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5996 HGNC: 9991 AceView: RGS1 Ensembl:ENSG00000090104 euGenes: HUgn5996
    ECgene: RGS1 H-InvDB: RGS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RGS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RGS1 gene:
    Search GeneIP for patents involving RGS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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