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RGS1 Gene

protein-coding   GIFtS: 61
GCID: GC01P192544

Regulator Of G-Protein Signaling 1

(Previous name: regulator of G-protein signalling 1)
(Previous symbol: IER1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of G-Protein Signaling 11 2     B-Cell Activation Protein BL342 3
IER11 2 3 5     IR202 5
Regulator Of G-Protein Signalling 11 2     HEL-S-872
Early Response Protein 1R202 3     Epididymis Secretory Protein Li 872
1R202 3     Immediate-Early Response 1, B-Cell Specific2
BL342 3     

External Ids:    HGNC: 99911   Entrez Gene: 59962   Ensembl: ENSG000000901047   OMIM: 6003235   UniProtKB: Q081163   

Export aliases for RGS1 gene to outside databases

Previous GC identifers: GC01P190335 GC01P188059 GC01P189011 GC01P189833 GC01P189276 GC01P190811 GC01P163781


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGS1 Gene:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the
cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The
protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and
acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis
allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers,
thereby terminating the signal. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGS1 Gene:
RGS1 (regulator of G-protein signaling 1) is a protein-coding gene. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell
activation and proliferation

Gene Wiki entry for RGS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGS1 gene promoter:
         TBP   Nkx2-5   IRF-1   Nkx5-1   E47   TFIID   STAT3   Hand1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGS1 promoter sequence
   Search Chromatin IP Primers for RGS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31

RGS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P192544:  view genomic region     (about GC identifiers)

Start:
192,544,857 bp from pter      End:
192,549,161 bp from pter
Size:
4,305 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116 (See protein sequence)
Recommended Name: Regulator of G-protein signaling 1  
Size: 209 amino acids; 23858 Da
Sequence caution: Sequence=AAB26289.1; Type=Erroneous initiation; Sequence=AAH15510.1; Type=Erroneous initiation;
Sequence=BAG37976.1; Type=Erroneous initiation; Sequence=BAG64242.1; Type=Erroneous initiation;
Sequence=CAA51826.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for RGS1:
2BV1 (3D)        2GTP (3D)    
Secondary accessions: B2RDM9 B4DZY0 Q07918 Q9H1W2
Alternative splicing: 2 isoforms:  Q08116-1   Q08116-2   

Explore the universe of human proteins at neXtProt for RGS1: NX_Q08116

Explore proteomics data for RGS1 at MOPED

Post-translational modifications: 

  • Could be phosphorylated. Might be functionally regulated by protein kinase(s)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RGS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002913.3  
    ENSEMBL proteins: 
     ENSP00000356429   ENSP00000464323  
    Reactome Protein details: Q08116

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    antibodies-online peptides for RGS1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RGS: Regulators of G-protein signaling

    3 InterPro protein domains:
     IPR024066 Regulat_G_prot_signal_dom1
     IPR016137 Regulat_G_prot_signal_superfam
     IPR000342 RGS_dom

    Graphical View of Domain Structure for InterPro Entry Q08116

    ProtoNet protein and cluster: Q08116

    1 Blocks protein domain: IPB000342 Regulator of G-protein signalling (RGS) protein signature

    UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116
    Similarity: Contains 1 RGS domain


    Find genes that share domains with RGS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGS1_HUMAN, Q08116
    Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby
    driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell
    activation and proliferation
    Induction: In response to several B-cell activation signals

         Genatlas biochemistry entry for RGS1:
    negative regulator of G-protein signaling 1,23kDa,functioning as GTPase-activating protein for G protein alpha
    subunits,G alpha i and G alpha o,abundantly expressed in B cells,C elegans EGL-10 and yeast SST2 homolog

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005516calmodulin binding TAS10747990
         
    Find genes that share ontologies with RGS1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rgs1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with RGS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgs1tm1Jhk for RGS1

       genOway: Develop your customized and physiologically relevant rodent model for RGS1

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    SwitchGear 3'UTR luciferase reporter plasmidRGS1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--

    Find genes that share ontologies with RGS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGS1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    4Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    5Peptide ligand-binding receptors
    G alpha (i) signalling events0.44


    Find genes that share SuperPaths with RGS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RGS1
        cAMP Pathway
    G-AlphaI Signaling
    G-AlphaQ Signaling

    3 BioSystems Pathways for RGS1
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    CXCR4-mediated signaling events


    1 Reactome Pathway for RGS1
        G alpha (i) signalling events

    1 PharmGKB Pathway for RGS1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RGS1
    Interactions:

        Search GeneGlobe Interaction Network for RGS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RGS1 (Q081162, 3 ENSP000003564294) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUNDC2Q9BWH22, 3, ENSP000003585104MINT-64062 I2D: score=5 STRING: ENSP00000358510
    TSC22D1Q157142, 3MINT-64060 I2D: score=5 
    UTP14AQ9BVJ62, 3MINT-64061 I2D: score=5 
    MAP3K12Q128522, 3MINT-64059 I2D: score=4 
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS8241276
    GO:0007165signal transduction NAS8241276
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS10480894
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--
    GO:0043547positive regulation of GTPase activity TAS10747990

    Find genes that share ontologies with RGS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGS1

    4 Novoseek inferred chemical compound relationships for RGS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 44 1 8774882 (1)
    gtp 42.5 1 11520900 (1)
    cycloheximide 32.4 1 9174164 (1)
    calcium 0 2 9174164 (1), 9539105 (1)



    Find genes that share compounds with RGS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGS1 gene: 
    NM_002922.3  

    Unigene Cluster for RGS1:

    Regulator of G-protein signaling 1
    Hs.75256  [show with all ESTs]
    Unigene Representative Sequence: NM_002922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367459(uc001gsi.1) ENST00000474373 ENST00000462589 ENST00000583155
    ENST00000469578(uc010pou.1) ENST00000498352
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    hsa-miR-374c hsa-miR-223 hsa-miR-655 hsa-miR-1237 hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidRGS1 3' UTR sequence
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    Additional mRNA sequence: 

    AF493925.1 AK303138.1 AK315607.1 BC015510.1 BT006668.1 X73427.1 

    12 DOTS entries:

    DT.92433858  DT.95275919  DT.316113  DT.91796220  DT.121383703  DT.40306067  DT.91919646  DT.92433847 
    DT.121383666  DT.100789138  DT.95275923  DT.92433856 

    Selected AceView cDNA sequences (see all 203):

    Z43095 AI365672 AI500122 AI734842 AF493925 AA962409 AI499885 BM998740 
    AI860070 CA419209 BU177934 AI365673 AV725023 AI708793 AW292368 AI961570 
    AI262426 AA563873 AI912421 CA309110 BI752145 AA570239 AI245011 AW235917 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RGS1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
    SP1:                                                              -                     
    SP2:                                                                                    
    SP3:                                                              -                     
    SP4:                                -     -     -     -           -                     
    SP5:                          -     -                                                   


    ECgene alternative splicing isoforms for RGS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTGCTAC
    RGS1 Expression
    About this image


    RGS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
    RGS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75256

    UniProtKB/Swiss-Prot: RGS1_HUMAN, Q08116
    Tissue specificity: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia
    B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia,
    expression is constitutively high

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RGS1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgs11 , 5 regulator of G-protein signaling 11, 5 87.88(n)1
    86.6(a)1
      1 (62.56 cM)5
    507781  NM_015811.21  NP_056626.21 
     1442439725 
    chicken
    (Gallus gallus)
    Aves RGS11 regulator of G-protein signaling 1 70.41(n)
    66.33(a)
      424360  XM_422203.4  XP_422203.3 
    lizard
    (Anolis carolinensis)
    Reptilia RGS16
    regulator of G-protein signaling 1
    54(a)
    1 ↔ 1
    GL343267.1(1551717-1561081)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rgs11 regulator of G-protein signaling 1 62.81(n)
    57.37(a)
      496714  XM_002939078.2  XP_002939124.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rgs131 regulator of G-protein signaling 13 58.52(n)
    53.33(a)
      100037359  NM_001089512.1  NP_001082981.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50366
    --
    25(a)
    1 → many
    2R(13680387-13685633)
    worm
    (Caenorhabditis elegans)
    Secernentea rgs-26
    rgs-16
    Protein RGS-1, isoform b
    33(a)
    23(a)
    many ↔ many
    many ↔ many
    X(12712653-12728389) WBGene00004345
    III(10014593-10016534) WBGene00004344


    ENSEMBL Gene Tree for RGS1 (if available)
    TreeFam Gene Tree for RGS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGS1 gene
    RGS22  RGS82  RGS192  RGS212  RGS32  RGS202  RGS162  RGS172  
    RGS52  RGS182  RGS132  RGS42  
    17 SIMAP similar genes for RGS1 using alignment to 1 protein entry:     RGS1_HUMAN:
    RGS21    RGS8    RGS13    RGS18    RGS20    RGS4
    RGS17    RGS5    RGS19    RGS16    RGS7    RGS3
    RGS10    RGS2    RGS6    RGS9    RGS12

    Find genes that share paralogs with RGS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGS1 (see all 165)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406003151,2
    --192542939(+) CAGTTA/GTAAAT 1 -- us2k10--------
    rs109211991,2
    C,F,A,H--192542951(+) CTTGCG/ACTTCA 1 -- us2k15Minor allele frequency- A:0.03NS EA WA 520
    rs741306881,2
    C,F--192543002(+) TCAGAG/ACAGTT 1 -- us2k12Minor allele frequency- A:0.21WA 120
    rs1885178671,2
    --192543134(+) AACAAA/GTTAGG 1 -- us2k10--------
    rs67017951,2
    C,F,A,H--192543142(+) AGGAGT/CCCAAC 1 -- us2k15Minor allele frequency- C:0.06NS EA WA 526
    rs109212001,2
    C,F,H--192543180(+) TTTTTG/ACTGCT 1 -- us2k15Minor allele frequency- A:0.04NS EA WA 532
    rs1445500891,2
    C--192543406(+) TGTCAC/TCTGTC 1 -- us2k10--------
    rs1473984351,2
    --192543408(+) TCATCA/TGTCTT 1 -- us2k10--------
    rs1396333101,2
    C--192543424(+) TTCATC/TGGTCT 1 -- us2k10--------
    rs109212011,2
    C,F,A,H--192543428(+) TCGGTC/TTCATT 1 -- us2k15Minor allele frequency- T:0.04NS EA WA 538

    HapMap Linkage Disequilibrium report for RGS1 (192544857 - 192549161 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RGS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3954CNV Insertion18451855
    nsv466994CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RGS1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600323    OMIM disorders: --


    Find genes that share disorders with RGS1           About GenesLikeMe

    Genetic Association Database (GAD): RGS1
    Human Genome Epidemiology (HuGE) Navigator: RGS1 (15 documents)

    Export disorders for RGS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGS1 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with RGS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. (PubMed id 8241276)1, 2, 3 Newton J.S.... Norton J.D. (Biochim. Biophys. Acta 1993)
    2. Multiple sclerosis susceptibility alleles in African Americans. (PubMed id 19865102)1, 4 Johnson B.A....Oksenberg J.R. (Genes Immun. 2010)
    3. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    4. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PubMed id 20627871)1, 4 Wang J....Wu X. (Carcinogenesis 2010)
    5. Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort. (PubMed id 19693089)1, 4 Amundsen S.S....Sollid L.M. (Genes Immun. 2010)
    6. Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. (PubMed id 20647273)1, 4 Hinks A....Thomson W. (Ann. Rheum. Dis. 2010)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease. (PubMed id 18805825)1, 4 Romanos J....Wijmenga C. (J. Med. Genet. 2009)
    10. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PubMed id 19879194)1, 4 De Jager P.L....Karlson E.W. (Lancet Neurol 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5996 HGNC: 9991 AceView: RGS1 Ensembl:ENSG00000090104 euGenes: HUgn5996
    ECgene: RGS1 H-InvDB: RGS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RGS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RGS1 gene:
    Search GeneIP for patents involving RGS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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