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Aliases for RGS1 Gene

Aliases for RGS1 Gene

  • Regulator Of G-Protein Signaling 1 2 3
  • IER1 3 4 6
  • Regulator Of G-Protein Signalling 1 2 3
  • B-Cell Activation Protein BL34 3 4
  • Early Response Protein 1R20 3 4
  • IR20 3 6
  • 1R20 3 4
  • BL34 3 4
  • Immediate-Early Response 1, B-Cell Specific 3
  • Epididymis Secretory Protein Li 87 3
  • HEL-S-87 3

External Ids for RGS1 Gene

Previous HGNC Symbols for RGS1 Gene

  • IER1

Previous GeneCards Identifiers for RGS1 Gene

  • GC01P190335
  • GC01P188059
  • GC01P189011
  • GC01P189833
  • GC01P189276
  • GC01P190811
  • GC01P163781

Summaries for RGS1 Gene

Entrez Gene Summary for RGS1 Gene

  • This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS1 Gene

RGS1 (Regulator Of G-Protein Signaling 1) is a Protein Coding gene. Diseases associated with RGS1 include chronic lymphocytic leukemia. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS1 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation

Gene Wiki entry for RGS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS1 Gene

Genomics for RGS1 Gene

Regulatory Elements for RGS1 Gene

Genomic Location for RGS1 Gene

192,575,727 bp from pter
192,580,031 bp from pter
4,305 bases
Plus strand

Genomic View for RGS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS1 Gene

Proteins for RGS1 Gene

  • Protein details for RGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 1
    Protein Accession:
    Secondary Accessions:
    • B2RDM9
    • B4DZY0
    • Q07918
    • Q9H1W2

    Protein attributes for RGS1 Gene

    209 amino acids
    Molecular mass:
    23858 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB26289.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15510.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37976.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG64242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGS1 Gene

    Alternative splice isoforms for RGS1 Gene


neXtProt entry for RGS1 Gene

Proteomics data for RGS1 Gene at MOPED

Post-translational modifications for RGS1 Gene

  • Could be phosphorylated. Might be functionally regulated by protein kinase(s)
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS1 Gene

Domains for RGS1 Gene

Gene Families for RGS1 Gene

  • RGS :Regulators of G-protein signaling

Protein Domains for RGS1 Gene

Suggested Antigen Peptide Sequences for RGS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q08116
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS1: view

Function for RGS1 Gene

Molecular function for RGS1 Gene

GENATLAS Biochemistry: negative regulator of G-protein signaling 1,23kDa,functioning as GTPase-activating protein for G protein alpha subunits,G alpha i and G alpha o,abundantly expressed in B cells,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation
UniProtKB/Swiss-Prot Induction: In response to several B-cell activation signals

Gene Ontology (GO) - Molecular Function for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005516 calmodulin binding TAS 10747990
genes like me logo Genes that share ontologies with RGS1: view

Phenotypes for RGS1 Gene

genes like me logo Genes that share phenotypes with RGS1: view

Animal Models for RGS1 Gene

MGI Knock Outs for RGS1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RGS1 Gene

Localization for RGS1 Gene

Subcellular locations from

Jensen Localization Image for RGS1 Gene COMPARTMENTS Subcellular localization image for RGS1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGS1 Gene

Pathways for RGS1 Gene

genes like me logo Genes that share pathways with RGS1: view

Gene Ontology (GO) - Biological Process for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 8241276
GO:0007165 signal transduction NAS 8241276
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 10480894
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with RGS1: view

Compounds for RGS1 Gene

(4) Novoseek inferred chemical compound relationships for RGS1 Gene

Compound -log(P) Hits PubMed IDs
gdp 44 1
gtp 42.5 1
cycloheximide 32.4 1
calcium 0 2
genes like me logo Genes that share compounds with RGS1: view

Transcripts for RGS1 Gene

Unigene Clusters for RGS1 Gene

Regulator of G-protein signaling 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGS1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RGS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP3: -
SP4: - - - - -
SP5: - -

Relevant External Links for RGS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS1 Gene

mRNA expression in normal human tissues for RGS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.8) and Nerve - Tibial (4.1).

SOURCE GeneReport for Unigene cluster for RGS1 Gene Hs.75256

mRNA Expression by UniProt/SwissProt for RGS1 Gene

Tissue specificity: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high
genes like me logo Genes that share expressions with RGS1: view

In Situ Assay Products

No data available for Protein expression for RGS1 Gene

Orthologs for RGS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS1 35
  • 100 (n)
  • 100 (a)
RGS1 36
  • 100 (a)
(Bos Taurus)
Mammalia RGS1 35
  • 90.91 (n)
  • 90.91 (a)
RGS1 36
  • 91 (a)
(Canis familiaris)
Mammalia RGS1 35
  • 89.95 (n)
  • 89 (a)
RGS1 36
  • 89 (a)
(Mus musculus)
Mammalia Rgs1 35
  • 87.88 (n)
  • 86.6 (a)
Rgs1 16
Rgs1 36
  • 87 (a)
(Monodelphis domestica)
Mammalia RGS1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
-- 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Rgs1 35
  • 88.27 (n)
  • 91.36 (a)
(Gallus gallus)
Aves RGS1 35
  • 70.41 (n)
  • 66.33 (a)
RGS1 36
  • 64 (a)
(Anolis carolinensis)
Reptilia RGS1 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs1 35
  • 62.81 (n)
  • 57.37 (a)
(Danio rerio)
Actinopterygii rgs1 36
  • 43 (a)
rgs13 35
  • 58.52 (n)
  • 53.33 (a)
rgs13 36
  • 43 (a)
si:ch211-117l17.5 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5036 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea rgs-1 36
  • 23 (a)
rgs-2 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for RGS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS1 Gene

Gene Tree for RGS1 (if available)
Gene Tree for RGS1 (if available)

Paralogs for RGS1 Gene

Paralogs for RGS1 Gene

Selected SIMAP similar genes for RGS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS1: view

Variants for RGS1 Gene

Sequence variations from dbSNP and Humsavar for RGS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1049479 -- 192,579,386(+) TATGG(A/C)TCCCT utr-variant-3-prime
rs1049480 -- 192,579,454(+) CAGAA(C/T)GGATT utr-variant-3-prime
rs1323291 -- 192,579,413(-) ACCCA(A/C)AAAAG utr-variant-3-prime
rs1547624 -- 192,574,707(-) AGAAG(A/T)TAGTA upstream-variant-2KB
rs1923948 -- 192,578,518(+) ATAAA(A/T)ATAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS1 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990
nsv3954 CNV Insertion 18451855

Relevant External Links for RGS1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS1 Gene

Disorders for RGS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RGS1 Gene including...

Search for RGS1 Gene in MalaCards »

Relevant External Links for RGS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RGS1: view

No data available for UniProtKB/Swiss-Prot for RGS1 Gene

Publications for RGS1 Gene

  1. A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. (PMID: 8241276) Newton J.S. … Norton J.D. (Biochim. Biophys. Acta 1993) 2 3 4
  2. Isolation and characterization of a novel B cell activation gene. (PMID: 8473738) Hong J.X. … Kehrl J.H. (J. Immunol. 1993) 3 4
  3. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PMID: 8602223) Druey K.M. … Kehrl J.H. (Nature 1996) 2 3
  4. Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members. (PMID: 9774420) Bowman E.P. … Butcher E.C. (J. Biol. Chem. 1998) 3 23
  5. Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha. (PMID: 11520900) Hoffmann M. … Milligan G. (J. Neurochem. 2001) 3 23

Products for RGS1 Gene

Sources for RGS1 Gene

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