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Aliases for RGS1 Gene

Aliases for RGS1 Gene

  • Regulator Of G-Protein Signaling 1 2 3 5
  • Regulator Of G-Protein Signalling 1 2 3
  • B-Cell Activation Protein BL34 3 4
  • Early Response Protein 1R20 3 4
  • IER1 3 4
  • 1R20 3 4
  • BL34 3 4
  • Immediate-Early Response 1, B-Cell Specific 3
  • Epididymis Secretory Protein Li 87 3
  • HEL-S-87 3
  • IR20 3

External Ids for RGS1 Gene

Previous HGNC Symbols for RGS1 Gene

  • IER1

Previous GeneCards Identifiers for RGS1 Gene

  • GC01P190335
  • GC01P188059
  • GC01P189011
  • GC01P189833
  • GC01P189276
  • GC01P190811
  • GC01P163781

Summaries for RGS1 Gene

Entrez Gene Summary for RGS1 Gene

  • This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS1 Gene

RGS1 (Regulator Of G-Protein Signaling 1) is a Protein Coding gene. Among its related pathways are G-protein activation and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTPase activator activity and calmodulin binding. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS1 Gene

  • Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).

Gene Wiki entry for RGS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS1 Gene

Genomics for RGS1 Gene

Regulatory Elements for RGS1 Gene

Enhancers for RGS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS1 Gene

Chromosome:
1
Start:
192,575,727 bp from pter
End:
192,580,031 bp from pter
Size:
4,305 bases
Orientation:
Plus strand

Genomic View for RGS1 Gene

Genes around RGS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS1 Gene

Proteins for RGS1 Gene

  • Protein details for RGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08116-RGS1_HUMAN
    Recommended name:
    Regulator of G-protein signaling 1
    Protein Accession:
    Q08116
    Secondary Accessions:
    • B2RDM9
    • B4DZY0
    • Q07918
    • Q9H1W2

    Protein attributes for RGS1 Gene

    Size:
    209 amino acids
    Molecular mass:
    23858 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAQ.
    SequenceCaution:
    • Sequence=AAB26289.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15510.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37976.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG64242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGS1 Gene

    Alternative splice isoforms for RGS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS1 Gene

Proteomics data for RGS1 Gene at MOPED

Post-translational modifications for RGS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RGS1 Gene

Domains & Families for RGS1 Gene

Gene Families for RGS1 Gene

Protein Domains for RGS1 Gene

Suggested Antigen Peptide Sequences for RGS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08116

UniProtKB/Swiss-Prot:

RGS1_HUMAN :
  • Contains 1 RGS domain.
Domain:
  • Contains 1 RGS domain.
genes like me logo Genes that share domains with RGS1: view

Function for RGS1 Gene

Molecular function for RGS1 Gene

GENATLAS Biochemistry:
negative regulator of G-protein signaling 1,23kDa,functioning as GTPase-activating protein for G protein alpha subunits,G alpha i and G alpha o,abundantly expressed in B cells,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).
UniProtKB/Swiss-Prot Induction:
In response to several B-cell activation signals.
genes like me logo Genes that share phenotypes with RGS1: view

Animal Models for RGS1 Gene

MGI Knock Outs for RGS1:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS1

miRNA for RGS1 Gene

miRTarBase miRNAs that target RGS1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS1 Gene

Localization for RGS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS1 Gene COMPARTMENTS Subcellular localization image for RGS1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 10480894
genes like me logo Genes that share ontologies with RGS1: view

Pathways & Interactions for RGS1 Gene

genes like me logo Genes that share pathways with RGS1: view

Gene Ontology (GO) - Biological Process for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 8241276
GO:0007165 signal transduction IDA,NAS 10480894
GO:0009968 negative regulation of signal transduction IEA --
GO:0061737 leukotriene signaling pathway IDA 10480894
genes like me logo Genes that share ontologies with RGS1: view

No data available for SIGNOR curated interactions for RGS1 Gene

Drugs & Compounds for RGS1 Gene

(1) Drugs for RGS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for RGS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS1: view

Transcripts for RGS1 Gene

Unigene Clusters for RGS1 Gene

Regulator of G-protein signaling 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: -
SP4: - - - - -
SP5: - -
SP6:

Relevant External Links for RGS1 Gene

GeneLoc Exon Structure for
RGS1
ECgene alternative splicing isoforms for
RGS1

Expression for RGS1 Gene

mRNA expression in normal human tissues for RGS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.8) and Nerve - Tibial (x4.1).

SOURCE GeneReport for Unigene cluster for RGS1 Gene Hs.75256

mRNA Expression by UniProt/SwissProt for RGS1 Gene

Q08116-RGS1_HUMAN
Tissue specificity: Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).
genes like me logo Genes that share expression patterns with RGS1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RGS1 Gene

Orthologs for RGS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RGS1 35
  • 90.91 (n)
  • 90.91 (a)
RGS1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS1 35
  • 89.95 (n)
  • 89 (a)
RGS1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs1 35
  • 87.88 (n)
  • 86.6 (a)
Rgs1 16
Rgs1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RGS1 35
  • 100 (n)
  • 100 (a)
RGS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rgs1 35
  • 88.27 (n)
  • 91.36 (a)
oppossum
(Monodelphis domestica)
Mammalia RGS1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves RGS1 35
  • 70.41 (n)
  • 66.33 (a)
RGS1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs1 35
  • 62.81 (n)
  • 57.37 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs13 35
  • 58.52 (n)
  • 53.33 (a)
rgs1 36
  • 43 (a)
ManyToMany
rgs13 36
  • 43 (a)
ManyToMany
si:ch211-117l17.5 36
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5036 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-1 36
  • 23 (a)
ManyToMany
rgs-2 36
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for RGS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS1 Gene

ENSEMBL:
Gene Tree for RGS1 (if available)
TreeFam:
Gene Tree for RGS1 (if available)

Paralogs for RGS1 Gene

Paralogs for RGS1 Gene

(17) SIMAP similar genes for RGS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS1: view

Variants for RGS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS1 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990
nsv3954 CNV Insertion 18451855

Variation tolerance for RGS1 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS1 Gene

HapMap Linkage Disequilibrium report
RGS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RGS1 Gene

Disorders for RGS1 Gene

Relevant External Links for RGS1

Genetic Association Database (GAD)
RGS1
Human Genome Epidemiology (HuGE) Navigator
RGS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS1

No disorders were found for RGS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS1 Gene

Publications for RGS1 Gene

  1. A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. (PMID: 8241276) Newton J.S. … Norton J.D. (Biochim. Biophys. Acta 1993) 2 3 4 67
  2. RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. (PMID: 16565322) Han J.I. … Kehrl J.H. (J. Leukoc. Biol. 2006) 3 23
  3. CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells. (PMID: 15728464) Le Y. … Silberstein L.E. (J. Immunol. 2005) 3 23
  4. Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha. (PMID: 11520900) Hoffmann M. … Milligan G. (J. Neurochem. 2001) 3 23
  5. Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members. (PMID: 9774420) Bowman E.P. … Butcher E.C. (J. Biol. Chem. 1998) 3 23

Products for RGS1 Gene

Sources for RGS1 Gene

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