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RGR Gene

protein-coding   GIFtS: 62
GCID: GC10P085994

Retinal G Protein Coupled Receptor

  See RGR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinal G Protein Coupled Receptor1 2
RGR-opsin1 2
RP442 5
RPE Retinal G-Protein Coupled Receptor2
RPE-Retinal G Protein-Coupled Receptor2

External Ids:    HGNC: 99901   Entrez Gene: 59952   Ensembl: ENSG000001486047   OMIM: 6003425   UniProtKB: P478043   

Export aliases for RGR gene to outside databases

Previous GC identifers: GC10P084961 GC10P085226 GC10P086136 GC10P085669 GC10P079850


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RGR Gene:
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of
the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains
a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze
the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal
photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the
retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal
dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript
variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for RGR Gene:
RGR (retinal G protein coupled receptor) is a protein-coding gene. Diseases associated with RGR include rgr-related retinitis pigmentosa, and retinitis pigmentosa 44. GO annotations related to this gene include photoreceptor activity and G-protein coupled receptor activity. An important paralog of this gene is OPN3.

UniProtKB/Swiss-Prot: RGR_HUMAN, P47804
Function: Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the
isomerization of the chromophore by a retinochrome-like mechanism

Gene Wiki entry for RGR (Retinal G protein coupled receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the RGR gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRGR promoter sequence
   Search Chromatin IP Primers for RGR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RGR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q23.1   HGNC cytogenetic band: 10q23

RGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RGR gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P085994:  view genomic region     (about GC identifiers)

Start:
86,004,809 bp from pter      End:
86,019,716 bp from pter
Size:
14,908 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGR_HUMAN, P47804 (See protein sequence)
Recommended Name: RPE-retinal G protein-coupled receptor  
Size: 291 amino acids; 31874 Da
Secondary accessions: A6NKK7 Q96FC5
Alternative splicing: 3 isoforms:  P47804-1   P47804-2   P47804-3   

Explore the universe of human proteins at neXtProt for RGR: NX_P47804

Explore proteomics data for RGR at MOPED

Post-translational modifications: 

  • Covalently binds all-trans- and 11-cis-retinal1
  • Glycosylation2 at Asn172

  • See RGR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001012738.1  NP_001012740.1  NP_002912.2  

    ENSEMBL proteins: 
     ENSP00000352427   ENSP00000361164   ENSP00000350823  
    Reactome Protein details: P47804

    RGR Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RGR

     
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    antibodies-online proteins for RGR (3 products) 

     
    antibodies-online peptides for RGR

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OPN: GPCR / Class A : Opsin receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR027430 Retinal_BS
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR001793 RPE_GPCR

    Graphical View of Domain Structure for InterPro Entry P47804

    ProtoNet protein and cluster: P47804

    2 Blocks protein domains:
    IPB001760 Opsin
    IPB001793 Retinal pigment epithelium-retinal GPCR signature


    UniProtKB/Swiss-Prot: RGR_HUMAN, P47804
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    Find genes that share domains with RGR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGR_HUMAN, P47804
    Function: Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the
    isomerization of the chromophore by a retinochrome-like mechanism

         Genatlas biochemistry entry for RGR:
    retinal opsin related,(rhodopsin homolog)expressed in the retinal pigment epithelium,encoding a
    retinaldehyde,preferentially all-trans retinal,binding protein,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8641686
    GO:0004950chemokine receptor activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0009881photoreceptor activity IEA--
         
    Find genes that share ontologies with RGR           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rgr):
     vision/eye 

    Find genes that share phenotypes with RGR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rgrtm1Hkf for RGR

       genOway: Develop your customized and physiologically relevant rodent model for RGR

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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGR_HUMAN, P47804: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with RGR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RGR About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    3Opsins
    Opsins


    Find genes that share SuperPaths with RGR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for RGR
        G alpha (i) signalling events
    Opsins


        Pathway & Disease-focused RT2 Profiler PCR Array including RGR: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RGR

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RGR (P478041, 2, 3 ENSP000003524274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA1279Q96EK51, 2, 3, ENSP000003548484EBI-745818,EBI-744150 MINT-66728 I2D: score=6 STRING: ENSP00000354848
    RDH5Q927813, ENSP000002578954I2D: score=1 STRING: ENSP00000257895
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS8641686
    GO:0007601visual perception IEA--
    GO:0007602phototransduction IEA--
    GO:0018298protein-chromophore linkage IEA--

    Find genes that share ontologies with RGR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RGR

    1 HMDB Compound for RGR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Retinal3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal (see all 19)116-31-4--

    3 Novoseek inferred chemical compound relationships for RGR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    11-cis-retinol 81.5 1 11852972 (1)
    retinoid 69 2 11086144 (1), 14742273 (1)
    vitamin a 51.2 1 12407145 (1)



    Find genes that share compounds with RGR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RGR gene (3 alternative transcripts): 
    NM_001012720.1  NM_001012722.1  NM_002921.3  

    Unigene Cluster for RGR:

    Retinal G protein coupled receptor
    Hs.1544  [show with all ESTs]
    Unigene Representative Sequence: BX641033
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469446 ENST00000478727 ENST00000359452(uc001kdd.1 uc001kdc.1 uc001kde.1)
    ENST00000483660 ENST00000372092(uc001kdb.1) ENST00000483771 ENST00000483744
    ENST00000497161 ENST00000479725 ENST00000358110
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RGR:
    hsa-miR-4283
    SwitchGear 3'UTR luciferase reporter plasmidRGR 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat RGR

    Additional mRNA sequence: 

    BC008094.1 BC011349.1 BC027987.1 BX641033.1 U14910.1 

    9 DOTS entries:

    DT.207290  DT.100754799  DT.100754798  DT.95291163  DT.95340314  DT.97804812  DT.100022272  DT.121282849 
    DT.70101934 

    Selected AceView cDNA sequences (see all 45):

    BU730825 AL713378 BM708080 AI858943 AW949377 BM710540 BM708524 BU731262 
    BX641033 BM694752 BG819215 BG820359 BC027987 BG818112 AI417427 BM682252 
    CA394286 BC011349 BM713989 BQ638073 BC008094 BQ640662 BM686346 AL712389 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RGR (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:                                      -     -           -                       -                                       
    SP2:                                      -                 -                       -                                       
    SP3:                                                        -                       -                                       
    SP4:                    -     -     -     -     -           -                       -                                       
    SP5:                                      -     -           -                       -     -                                 


    ECgene alternative splicing isoforms for RGR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RGR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RGR Expression
    About this image


    RGR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    RGR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RGR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1544

    UniProtKB/Swiss-Prot: RGR_HUMAN, P47804
    Tissue specificity: Preferentially expressed at high levels in the retinal pigment epithelium (RPE) and Mueller
    cells of the neural retina

        Pathway & Disease-focused RT2 Profiler PCR Array including RGR: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RGR gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rgr1 , 5 retinal G protein coupled receptor1, 5 81.9(n)1
    81.44(a)1
      14 (21.29 cM)5
    578111  NM_021340.31  NP_067315.11 
     370374905 
    chicken
    (Gallus gallus)
    Aves RGR1 retinal G protein coupled receptor 67.25(n)
    63.07(a)
      423619  NM_001031216.1  NP_001026387.1 
    lizard
    (Anolis carolinensis)
    Reptilia RGR6
    retinal G protein coupled receptor
    56(a)
    1 ↔ 1
    GL343199.1(3386614-3415394)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.176092 Xenopus laevis transcribed sequence with weak similarity more 71.97(n)    BG812984.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgra1 retinal G protein coupled receptor a 62.12(n)
    57.34(a)
      550575  NM_001017877.1  NP_001017877.1 


    ENSEMBL Gene Tree for RGR (if available)
    TreeFam Gene Tree for RGR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RGR gene
    OPN32  OPN1MW22  OPN42  OPN1LW2  OPN1MW2  OPN1SW2  RHO2  RRH2  
    OPN52  
    1 SIMAP similar gene for RGR using alignment to 2 protein entries:     RGR_HUMAN (see all proteins):
    RRH

    Find genes that share paralogs with RGR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RGR (see all 427)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0170344
    Retinitis pigmentosa 44 (RP44)4--see VAR_0170342 S R mis40--------
    rs1048941871,2
    Cpathogenic186379316(+) GGATCA/CGCCTG 6 S R mis10--------
    rs617308951,2
    C,Funtested186389590(+) GACTTC/TCATCT 5 S F mis1 int15Minor allele frequency- T:0.03NS NA EA EU 6190
    rs1451297561,2
    C--79860971(+) GTTTT-/CTTTC 
            
    TTTTT
    3 -- int10--------
    rs344597571,2
    C--86010274(+) CTTAT-/AC/ACACACACA
    C
    /ACACACACACAC
    ACACA
    6 -- int1 cds10--------
    rs775716121,2
    C,F--86014502(+) GGTTGC/TTTATG 3 -- int11Minor allele frequency- T:0.02NA 120
    rs1116043561,2
    C,F--86015983(+) CCACGG/CCTGGC 3 -- int11Minor allele frequency- C:0.00CSA 1
    rs789371521,2
    C,F--86374803(+) TACTGG/ACTTCT 3 -- us2k12Minor allele frequency- A:0.08NA EA 240
    rs763190191,2
    C,F--86374824(+) TTCCTT/CCCAAT 3 -- us2k12Minor allele frequency- C:0.08CSA WA 120
    rs760280551,2
    C--86374835(+) GCAGCA/CAGTAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for RGR (86004809 - 86019716 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RGR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527522CNV Loss19592680
    nsv895828CNV Loss21882294

    Human Gene Mutation Database (HGMD): RGR
    Locus Specific Mutation Databases (LSDB): RGR

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600342   
    OMIM disorders: 613769  
    UniProtKB/Swiss-Prot: RGR_HUMAN, P47804
  • Retinitis pigmentosa 44 (RP44) [MIM:613769]: A retinal dystrophy belonging to the group of pigmentary
    retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination
    and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically
    have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose
    their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 7 diseases for RGR:    
    About MalaCards
    rgr-related retinitis pigmentosa    retinitis pigmentosa 44    ehrlichiosis    human monocytic ehrlichiosis
    human granulocytic anaplasmosis    leber congenital amaurosis    retinitis pigmentosa

    2 diseases from the University of Copenhagen DISEASES database for RGR:
    Human granulocytic anaplasmosis     Human monocytic ehrlichiosis

    Find genes that share disorders with RGR           About GenesLikeMe

    1 Novoseek inferred disease relationship for RGR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 77.3 5 11431696 (1), 17454745 (1), 10581022 (1), 12843338 (1)

    Genetic Association Database (GAD): RGR
    Human Genome Epidemiology (HuGE) Navigator: RGR (5 documents)

    Export disorders for RGR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RGR gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with RGR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human opsin-related gene that encodes a retinaldehyde-binding protein. (PubMed id 7947717)1, 2, 9 Shen D.... Fong H.K.W. (Biochemistry 1994)
    2. Localization of the human RGR opsin gene to chromosome 10q23. (PubMed id 8641686)1, 3, 9 Chen X.N....Fong H.K. (Hum. Genet. 1996)
    3. Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. (PubMed id 10581022)1, 2, 9 Morimura H.... Dryja T.P. (Nat. Genet. 1999)
    4. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PubMed id 20801516)1, 4 Booij J.C....Florijn R.J. (Ophthalmology 2011)
    5. Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa. (PubMed id 20591486)1, 4 Clark G.R.... Simpson D.A. (Ophthalmology 2010)
    6. Screening genes of the visual cycle RGR, RBP1 and RBP3 identifies rare sequence variations. (PubMed id 21067480)1, 4 Ksantini M....Hamel C.P. (Ophthalmic Genet. 2010)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Alternative splicing in human retinal mRNA transcripts of an opsin-related protein. (PubMed id 7789419)1, 9 Jiang M....Fong H.K. (Exp. Eye Res. 1995)
    10. Accumulation of extracellular RGR-d in Bruch's membrane and close association with drusen at intercapillary regions. (PubMed id 19450444)1, 9 Kochounian H....Fong H.K. (Exp. Eye Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5995 HGNC: 9990 AceView: RGR Ensembl:ENSG00000148604 euGenes: HUgn5995
    ECgene: RGR H-InvDB: RGR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RGR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RGR Genetics and Cytogenetics in Oncology and Haematology
    Mutations of the RGR genehttp://www.retina-international.org/files/sci-news/rgrmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=RGR[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RGR gene:
    Search GeneIP for patents involving RGR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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