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Aliases for RGPD8 Gene

Aliases for RGPD8 Gene

  • RANBP2-Like And GRIP Domain Containing 8 2 3
  • RAN Binding Protein 2-Like 1 2 3
  • Ran-Binding Protein 2-Like 3 3 4
  • RanBP2-Like 3 3 4
  • RanBP2alpha 3 4
  • RanBP2L1 3 4
  • RanBP2L3 3 4
  • RGP8 3

External Ids for RGPD8 Gene

Previous HGNC Symbols for RGPD8 Gene

  • RANBP2L1

Previous GeneCards Identifiers for RGPD8 Gene

  • GC02U900819
  • GC02M112843
  • GC02M113125
  • GC02M105644

Summaries for RGPD8 Gene

GeneCards Summary for RGPD8 Gene

RGPD8 (RANBP2-Like And GRIP Domain Containing 8) is a Protein Coding gene. Among its related pathways are RNA transport. GO annotations related to this gene include Ran GTPase binding. An important paralog of this gene is PPIE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD8 Gene

Genomics for RGPD8 Gene

Regulatory Elements for RGPD8 Gene

Genomic Location for RGPD8 Gene

Chromosome:
2
Start:
112,368,369 bp from pter
End:
112,434,488 bp from pter
Size:
66,120 bases
Orientation:
Minus strand

Genomic View for RGPD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RGPD8 Gene

Proteins for RGPD8 Gene

  • Protein details for RGPD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14715-RGPD8_HUMAN
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 8
    Protein Accession:
    O14715
    Secondary Accessions:
    • Q5CZA8

    Protein attributes for RGPD8 Gene

    Size:
    1765 amino acids
    Molecular mass:
    198993 Da
    Quaternary structure:
    • Interacts with GTP-bound ARL1.
    Miscellaneous:
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere

neXtProt entry for RGPD8 Gene

Proteomics data for RGPD8 Gene at MOPED

Post-translational modifications for RGPD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGPD8 Gene

No data available for DME Specific Peptides for RGPD8 Gene

Domains & Families for RGPD8 Gene

Gene Families for RGPD8 Gene

Protein Domains for RGPD8 Gene

Suggested Antigen Peptide Sequences for RGPD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14715

UniProtKB/Swiss-Prot:

RGPD8_HUMAN :
  • Contains 1 GRIP domain.
  • Contains 3 TPR repeats.
Domain:
  • Contains 1 GRIP domain.
  • Contains 2 RanBD1 domains.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with RGPD8: view

Function for RGPD8 Gene

Gene Ontology (GO) - Molecular Function for RGPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008536 Ran GTPase binding NAS 9480752
genes like me logo Genes that share ontologies with RGPD8: view

Animal Model Products

CRISPR Products

miRNA for RGPD8 Gene

miRTarBase miRNAs that target RGPD8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for RGPD8 Gene

Localization for RGPD8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGPD8 Gene COMPARTMENTS Subcellular localization image for RGPD8 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RGPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005643 nuclear pore NAS 9480752
genes like me logo Genes that share ontologies with RGPD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGPD8 Gene

Pathways & Interactions for RGPD8 Gene

SuperPathways for RGPD8 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD8: view

Pathways by source for RGPD8 Gene

1 KEGG pathway for RGPD8 Gene

Interacting Proteins for RGPD8 Gene

Gene Ontology (GO) - Biological Process for RGPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0008150 biological_process ND --
GO:0046907 intracellular transport --
genes like me logo Genes that share ontologies with RGPD8: view

No data available for SIGNOR curated interactions for RGPD8 Gene

Drugs & Compounds for RGPD8 Gene

(1) Drugs for RGPD8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RGPD8: view

Transcripts for RGPD8 Gene

mRNA/cDNA for RGPD8 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD8 Gene

RANBP2-like and GRIP domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD8 Gene

No ASD Table

Relevant External Links for RGPD8 Gene

GeneLoc Exon Structure for
RGPD8
ECgene alternative splicing isoforms for
RGPD8

Expression for RGPD8 Gene

mRNA expression in normal human tissues for RGPD8 Gene

Protein differential expression in normal tissues from HIPED for RGPD8 Gene

This gene is overexpressed in Testis (44.0), Heart (11.2), and Serum (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGPD8 Gene



SOURCE GeneReport for Unigene cluster for RGPD8 Gene Hs.535589

genes like me logo Genes that share expression patterns with RGPD8: view

Protein tissue co-expression partners for RGPD8 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RGPD8 Gene

Orthologs for RGPD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RANBP2 35
  • 85.07 (n)
  • 84.34 (a)
mouse
(Mus musculus)
Mammalia Ranbp2 35
  • 87.58 (n)
  • 88.11 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
ManyToMany
-- 36
  • 92 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RANBP2 35
  • 70.83 (n)
  • 68.66 (a)
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 35
  • 66.5 (n)
  • 62.47 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 35
  • 56.14 (n)
  • 54.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 9 (a)
ManyToMany
Y17G9B.4 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 5 (a)
OneToMany
Species with no ortholog for RGPD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD8 Gene

ENSEMBL:
Gene Tree for RGPD8 (if available)
TreeFam:
Gene Tree for RGPD8 (if available)

Paralogs for RGPD8 Gene

Paralogs for RGPD8 Gene

(8) SIMAP similar genes for RGPD8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RGPD8: view

Variants for RGPD8 Gene

Sequence variations from dbSNP and Humsavar for RGPD8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs530526783 -- 112,373,548(+) TGATA(C/T)AGTCA intron-variant
rs530539426 -- 112,420,099(+) TGGGA(G/T)GCAGA intron-variant
rs530668234 -- 112,376,737(+) GAGGC(A/G)GAGGT intron-variant
rs531067326 -- 112,432,143(+) GCAAA(C/G)TGACT intron-variant
rs531187048 -- 112,415,317(+) GAGGT(A/T)CACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD8 Gene

Variant ID Type Subtype PubMed ID
nsv874863 CNV Loss 21882294
nsv874871 CNV Gain 21882294
esv2720536 CNV Deletion 23290073

Variation tolerance for RGPD8 Gene

Gene Damage Index Score: 6.01; 74.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGPD8 Gene

HapMap Linkage Disequilibrium report
RGPD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD8 Gene

Disorders for RGPD8 Gene

Relevant External Links for RGPD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGPD8
genes like me logo Genes that share disorders with RGPD8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD8 Gene

Publications for RGPD8 Gene

  1. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11- q12. (PMID: 9480752) Nothwang H.G. … Hildebrandt F. (Genomics 1998) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 67
  4. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PMID: 18220336) Cantin G.T. … Yates J.R. III (J. Proteome Res. 2008) 67
  5. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PMID: 18691976) Daub H. … Mann M. (Mol. Cell 2008) 67

Products for RGPD8 Gene

Sources for RGPD8 Gene

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