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Aliases for RGPD8 Gene

Aliases for RGPD8 Gene

  • RANBP2-Like And GRIP Domain Containing 8 2 3 5
  • RAN Binding Protein 2-Like 1 2 3
  • Ran-Binding Protein 2-Like 3 3 4
  • RanBP2-Like 3 3 4
  • RanBP2alpha 3 4
  • RanBP2L1 3 4
  • RanBP2L3 3 4
  • RANBP2-Like And GRIP Domain-Containing Protein 8 3
  • RGP8 3

External Ids for RGPD8 Gene

Previous HGNC Symbols for RGPD8 Gene

  • RANBP2L1

Previous GeneCards Identifiers for RGPD8 Gene

  • GC02U900819
  • GC02M112843
  • GC02M113125
  • GC02M105644

Summaries for RGPD8 Gene

GeneCards Summary for RGPD8 Gene

RGPD8 (RANBP2-Like And GRIP Domain Containing 8) is a Protein Coding gene. Among its related pathways are RNA transport. GO annotations related to this gene include Ran GTPase binding. An important paralog of this gene is RGPD6.

Additional gene information for RGPD8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD8 Gene

Genomics for RGPD8 Gene

Regulatory Elements for RGPD8 Gene

Enhancers for RGPD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H112186 1.4 Ensembl ENCODE dbSUPER 33.7 +246.4 246383 2 HDAC1 TBP PKNOX1 ATF1 NFRKB ZBTB40 CHAMP1 TCF12 ZNF766 GATA2 RGPD8 ZC3H6 ENSG00000278962 FBLN7
GH02H112433 0.8 ENCODE 50.2 +0.7 686 0 ARID4B SIN3A ZNF2 RAD21 MIXL1 THAP11 ZNF654 ZNF362 MXD4 ZEB2 RGPD8 ZC3H6 CHCHD5 ENSG00000207383 ENSG00000243389 GC02M112369
GH02H112480 1.1 ENCODE 31.5 -47.8 -47824 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 RGPD8 POLR1B ENSG00000207383 CHCHD5 ENSG00000243389 TTL
GH02H112274 1.2 ENCODE 26.8 +158.7 158671 2 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A RGPD8 ANAPC1 POLR1B ZC3H6 RPS20P11 NDUFB4P6
GH02H111434 1.1 Ensembl dbSUPER 23.2 +994.1 994088 11 KLF1 ATF1 ETV1 BMI1 PYGO2 ZNF507 RELA YY1 IRF9 ZNF316 ANAPC1 RGPD6 RGPD8 ZC3H6 TMEM87B GC02P113411 ENSG00000280878
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGPD8 on UCSC Golden Path with GeneCards custom track

Promoters for RGPD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121935 1688 2001 ARID4B SIN3A ZNF2 RAD21 MIXL1 ZNF654 ZNF362 MXD4 ZEB2 KAT8

Genomic Location for RGPD8 Gene

112,368,369 bp from pter
112,434,488 bp from pter
66,120 bases
Minus strand

Genomic View for RGPD8 Gene

Genes around RGPD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGPD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGPD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD8 Gene

Proteins for RGPD8 Gene

  • Protein details for RGPD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q5CZA8

    Protein attributes for RGPD8 Gene

    1765 amino acids
    Molecular mass:
    198993 Da
    Quaternary structure:
    • Interacts with GTP-bound ARL1.
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

neXtProt entry for RGPD8 Gene

Post-translational modifications for RGPD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGPD8 Gene

Domains & Families for RGPD8 Gene

Gene Families for RGPD8 Gene

Suggested Antigen Peptide Sequences for RGPD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGPD8: view

No data available for UniProtKB/Swiss-Prot for RGPD8 Gene

Function for RGPD8 Gene

Phenotypes From GWAS Catalog for RGPD8 Gene

Gene Ontology (GO) - Molecular Function for RGPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008536 Ran GTPase binding NAS 9480752
genes like me logo Genes that share ontologies with RGPD8: view
genes like me logo Genes that share phenotypes with RGPD8: view

Animal Models for RGPD8 Gene

MGI Knock Outs for RGPD8:

Animal Model Products

CRISPR Products

miRNA for RGPD8 Gene

miRTarBase miRNAs that target RGPD8

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RGPD8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGPD8 Gene

Localization for RGPD8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGPD8 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005643 nuclear pore NAS 9480752
genes like me logo Genes that share ontologies with RGPD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGPD8 Gene

Pathways & Interactions for RGPD8 Gene

SuperPathways for RGPD8 Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD8: view

Pathways by source for RGPD8 Gene

1 KEGG pathway for RGPD8 Gene

Gene Ontology (GO) - Biological Process for RGPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0046907 intracellular transport IEA --
genes like me logo Genes that share ontologies with RGPD8: view

No data available for SIGNOR curated interactions for RGPD8 Gene

Drugs & Compounds for RGPD8 Gene

(1) Drugs for RGPD8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RGPD8: view

Transcripts for RGPD8 Gene

mRNA/cDNA for RGPD8 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD8 Gene

RANBP2-like and GRIP domain containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RGPD8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD8 Gene

No ASD Table

Relevant External Links for RGPD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGPD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RGPD8 Gene

This gene is overexpressed in Testis (44.0), Heart (11.2), and Serum (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGPD8 Gene

Protein tissue co-expression partners for RGPD8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RGPD8 Gene:


SOURCE GeneReport for Unigene cluster for RGPD8 Gene:


Evidence on tissue expression from TISSUES for RGPD8 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RGPD8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGPD8 Gene

Orthologs for RGPD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
-- 34
  • 96 (a)
-- 34
  • 92 (a)
-- 34
  • 82 (a)
(Mus musculus)
Mammalia Ranbp2 16 33
  • 87.58 (n)
(Bos Taurus)
Mammalia RANBP2 33
  • 85.07 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
-- 34
  • 74 (a)
(Gallus gallus)
Aves RANBP2 33
  • 70.83 (n)
-- 34
  • 60 (a)
-- 34
  • 48 (a)
-- 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 33
  • 66.5 (n)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 33
  • 56.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea Y17G9B.4 34
  • 13 (a)
T22F3.12 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 5 (a)
Species where no ortholog for RGPD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD8 Gene

Gene Tree for RGPD8 (if available)
Gene Tree for RGPD8 (if available)

Paralogs for RGPD8 Gene

(8) SIMAP similar genes for RGPD8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RGPD8: view

Variants for RGPD8 Gene

Sequence variations from dbSNP and Humsavar for RGPD8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000043652 -- 112,430,520(+) CCACT(A/C)CACTT intron-variant
rs1000097726 -- 112,380,412(+) ACTTC(A/G)GGAGG intron-variant
rs1000138102 -- 112,430,789(+) GACCC(C/T)GTCTC intron-variant
rs1000203792 -- 112,413,703(+) GACTT(C/T)TTTTG intron-variant
rs1000382912 -- 112,369,895(+) GGTGG(C/T)TTTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RGPD8 Gene

Variant ID Type Subtype PubMed ID
dgv1162e212 CNV gain 25503493
dgv1163e212 CNV loss 25503493
dgv4037n100 CNV gain 25217958
dgv4047n100 CNV loss 25217958
dgv730e214 CNV gain 21293372
esv2720536 CNV deletion 23290073
esv2751812 CNV loss 17911159
esv3575292 CNV gain 25503493
esv3584010 CNV loss 25503493
esv3584017 CNV loss 25503493
nsv1003103 CNV gain+loss 25217958
nsv1077368 CNV duplication 25765185
nsv1124804 CNV duplication 24896259
nsv1141358 CNV duplication 24896259
nsv1146907 CNV duplication 26484159
nsv1149522 OTHER inversion 26484159
nsv1153351 CNV duplication 26484159
nsv508159 CNV deletion 20534489
nsv510884 OTHER complex 20534489
nsv953789 CNV deletion 24416366
nsv961637 CNV duplication 23825009
nsv961864 CNV duplication 23825009
nsv963835 CNV duplication 23825009
nsv979088 CNV duplication 23825009
nsv979101 CNV duplication 23825009

Variation tolerance for RGPD8 Gene

Gene Damage Index Score: 6.01; 74.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGPD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD8 Gene

Disorders for RGPD8 Gene

Relevant External Links for RGPD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGPD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD8 Gene

Publications for RGPD8 Gene

  1. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12. (PMID: 9480752) Nothwang HG … Hildebrandt F (Genomics 1998) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner BA … Cristea IM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for RGPD8 Gene

Sources for RGPD8 Gene

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