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Aliases for RGPD8 Gene

Aliases for RGPD8 Gene

  • RANBP2-Like And GRIP Domain Containing 8 2 3 5
  • RAN Binding Protein 2-Like 1 2 3
  • Ran-Binding Protein 2-Like 3 3 4
  • RanBP2-Like 3 3 4
  • RanBP2alpha 3 4
  • RanBP2L1 3 4
  • RanBP2L3 3 4
  • RGP8 3

External Ids for RGPD8 Gene

Previous HGNC Symbols for RGPD8 Gene

  • RANBP2L1

Previous GeneCards Identifiers for RGPD8 Gene

  • GC02U900819
  • GC02M112843
  • GC02M113125
  • GC02M105644

Summaries for RGPD8 Gene

GeneCards Summary for RGPD8 Gene

RGPD8 (RANBP2-Like And GRIP Domain Containing 8) is a Protein Coding gene. Among its related pathways are RNA transport. GO annotations related to this gene include Ran GTPase binding. An important paralog of this gene is RGPD4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD8 Gene

Genomics for RGPD8 Gene

Regulatory Elements for RGPD8 Gene

Enhancers for RGPD8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RGPD8 on UCSC Golden Path with GeneCards custom track

Promoters for RGPD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RGPD8 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGPD8 Gene

112,368,369 bp from pter
112,434,488 bp from pter
66,120 bases
Minus strand

Genomic View for RGPD8 Gene

Genes around RGPD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGPD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGPD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD8 Gene

Proteins for RGPD8 Gene

  • Protein details for RGPD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q5CZA8

    Protein attributes for RGPD8 Gene

    1765 amino acids
    Molecular mass:
    198993 Da
    Quaternary structure:
    • Interacts with GTP-bound ARL1.
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

neXtProt entry for RGPD8 Gene

Proteomics data for RGPD8 Gene at MOPED

Post-translational modifications for RGPD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGPD8 Gene

No data available for DME Specific Peptides for RGPD8 Gene

Domains & Families for RGPD8 Gene

Gene Families for RGPD8 Gene

Suggested Antigen Peptide Sequences for RGPD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRIP domain.
  • Contains 3 TPR repeats.
  • Contains 1 GRIP domain.
  • Contains 2 RanBD1 domains.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with RGPD8: view

Function for RGPD8 Gene

genes like me logo Genes that share phenotypes with RGPD8: view

Animal Models for RGPD8 Gene

MGI Knock Outs for RGPD8:

Animal Model Products

CRISPR Products

miRNA for RGPD8 Gene

miRTarBase miRNAs that target RGPD8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGPD8 Gene

Localization for RGPD8 Gene

Subcellular locations from

Jensen Localization Image for RGPD8 Gene COMPARTMENTS Subcellular localization image for RGPD8 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RGPD8 Gene

Pathways & Interactions for RGPD8 Gene

SuperPathways for RGPD8 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD8: view

Pathways by source for RGPD8 Gene

1 KEGG pathway for RGPD8 Gene

Interacting Proteins for RGPD8 Gene

Gene Ontology (GO) - Biological Process for RGPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with RGPD8: view

No data available for SIGNOR curated interactions for RGPD8 Gene

Drugs & Compounds for RGPD8 Gene

(1) Drugs for RGPD8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RGPD8: view

Transcripts for RGPD8 Gene

mRNA/cDNA for RGPD8 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD8 Gene

RANBP2-like and GRIP domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD8 Gene

No ASD Table

Relevant External Links for RGPD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD8 Gene

mRNA expression in normal human tissues for RGPD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RGPD8 Gene

This gene is overexpressed in Testis (44.0), Heart (11.2), and Serum (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGPD8 Gene

SOURCE GeneReport for Unigene cluster for RGPD8 Gene Hs.535589

genes like me logo Genes that share expression patterns with RGPD8: view

Protein tissue co-expression partners for RGPD8 Gene

- Elite partner

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RGPD8 Gene

Orthologs for RGPD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RANBP2 35
  • 85.07 (n)
  • 84.34 (a)
(Mus musculus)
Mammalia Ranbp2 35
  • 87.58 (n)
  • 88.11 (a)
Ranbp2 16
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
-- 36
  • 83 (a)
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
-- 36
  • 92 (a)
-- 36
  • 82 (a)
-- 36
  • 96 (a)
(Gallus gallus)
Aves RANBP2 35
  • 70.83 (n)
  • 68.66 (a)
-- 36
  • 44 (a)
-- 36
  • 60 (a)
-- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 35
  • 66.5 (n)
  • 62.47 (a)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 35
  • 56.14 (n)
  • 54.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 9 (a)
Y17G9B.4 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 5 (a)
Species with no ortholog for RGPD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD8 Gene

Gene Tree for RGPD8 (if available)
Gene Tree for RGPD8 (if available)

Paralogs for RGPD8 Gene

Paralogs for RGPD8 Gene

(8) SIMAP similar genes for RGPD8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RGPD8: view

Variants for RGPD8 Gene

Sequence variations from dbSNP and Humsavar for RGPD8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1806770 -- 112,429,403(-) agtct(C/G)gctct intron-variant
rs1830474 -- 112,374,121(-) TTTGC(A/C)TCTCT intron-variant
rs2862225 -- 112,434,301(-) CTCTT(C/T)CCCCA upstream-variant-2KB
rs2918806 -- 112,383,502(+) CATTG(C/T)CTAGC intron-variant, downstream-variant-500B
rs2003966 -- 112,429,373(-) agtgt(C/T)gcgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD8 Gene

Variant ID Type Subtype PubMed ID
nsv874863 CNV Loss 21882294
nsv874871 CNV Gain 21882294
esv2720536 CNV Deletion 23290073

Variation tolerance for RGPD8 Gene

Gene Damage Index Score: 6.01; 74.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RGPD8 Gene

Disorders for RGPD8 Gene

Relevant External Links for RGPD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGPD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD8 Gene

Publications for RGPD8 Gene

  1. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11- q12. (PMID: 9480752) Nothwang H.G. … Hildebrandt F. (Genomics 1998) 2 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RGPD8 Gene

Sources for RGPD8 Gene