RGPD8 Gene
protein-coding GIFtS: 38
GCID: GC02M113125
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RANBP2-like and GRIP domain containing 8(Previous name: RAN binding protein 2-like 1 )
(Previous symbol: RANBP2L1)
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Aliases
for RGPD8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RANBP2-Like And GRIP Domain Containing 81 2 | | RGP82 5 | | RANBP2L11 2 3 5 | | RanBP2L33 | | RanBP2alpha1 2 | | RANBP2-Like And GRIP Domain-Containing Protein 82 | | RAN Binding Protein 2-Like 11 2 | | RANBP2ALPHA3 | | Ran-Binding Protein 2-Like 32 3 | | RANBP2L33 | | RanBP2-Like 32 3 | | RanBP2L33 |
Export aliases for RGPD8 gene to outside databasesPrevious GC identifers: GC02U900819 GC02M112843 GC02M105644 |
Summaries
for RGPD8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RGPD8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RGPD8 gene promoter:
HEN1 Pax-5 Nkx2-5 Ik-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RGPD8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGPD8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13RGPD8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M113125: view genomic region
(about GC identifiers)
Start:
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113,125,946 bp from pter |
End:
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113,192,065 bp from pter |
Size:
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66,120 bases |
Orientation:
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minus strand |
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Proteins
for RGPD8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RGPD8_HUMAN, O14715 (See
protein sequence)Recommended Name: RANBP2-like and GRIP domain-containing protein 8 Size: 1765 amino acids; 198993 Da
Subunit: Interacts with GTP-bound ARL1
Miscellaneous: One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere
Secondary accessions: Q5CZA8Explore the universe of human proteins at neXtProt for RGPD8: NX_O14715
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14715
RGPD8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001157935.1
ENSEMBL proteins: ENSP00000306637 ENSP00000386511 ENSP00000429923 ENSP00000327486 ENSP00000430052
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
RGPD8 for ontologies About GeneDecksing
RGPD8 Antibody Products:
Assay Products for RGPD8: |
Protein
Domains /
Families
for RGPD8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RGPD8 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O14715ProtoNet protein and cluster: O14715 1 Blocks protein family: IPB000156 RanBP1 domain
UniProtKB/Swiss-Prot: RGPD8_HUMAN, O14715Similarity: Contains 1 GRIP domainSimilarity: Contains 2 RanBD1 domainsSimilarity: Contains 3 TPR repeats |
Function
for RGPD8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RGPD8 (NM_001164463) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGPD8 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RGPD8 for ontologies About GeneDecksing
|
Pathways & Interactions
for RGPD8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RGPD8
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for RGPD8 (O147153 ENSP000003066374) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000042 | protein targeting to Golgi |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
RGPD8 for ontologies About GeneDecksing
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Drugs & Compounds
for RGPD8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RGPD8
1 HMDB Compound for RGPD8 About this table
Search CenterWatch for drugs/clinical trials and news about RGPD8
|
Transcripts
for RGPD8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RGPD8 gene: NM_001164463.1 Unigene Cluster for RGPD8: RANBP2-like and GRIP domain containing 8 Hs.535589 [show with all ESTs]Unigene Representative Sequence: NM_0011644637 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302558(uc002tht.1 uc002ths.2 uc010yxm.2) ENST00000409750(uc010fkk.2)
ENST00000522286 ENST00000330575 ENST00000482903 ENST00000496537 ENST00000471422
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RGPD8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RGPD8 (NM_001164463) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RGPD8 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD8 |
Additional cDNA sequence: AF012086.1 BC037274.1 EF491794.1 4 DOTS entries: DT.95274706 DT.91900581 DT.92409447 DT.75115124
GeneLoc Exon Structure
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Expression
for RGPD8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RGPD8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RGPD8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RGPD8
SOURCE GeneReport for Unigene cluster: Hs.535589
SABiosciences Custom PCR Arrays for RGPD8
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RGPD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGPD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGPD8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD8 |
Orthologs
for RGPD8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RGPD8 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for RGPD8 (if available)
TreeFam Gene Tree for RGPD8 (if available) |
Paralogs
for RGPD8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RGPD8 gene
- RGPD51 2 RGPD61 2 RGPD31 2 RGPD41 2 RGPD11 2 RGPD21 2 RANBP22 RANBP12
8 SIMAP similar genes for RGPD8 using alignment to 4 protein entries: RGPD8_HUMAN (see all proteins):RGPD5 RGPD6 RGPD3 RGPD1 RGPD2 RGPD4
RANBP2 RANBP1
RGPD8 for paralogs About GeneDecksing
|
Genomic Variants
for RGPD8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RGPD8 (113125946 - 113192065 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RGPD8
1 CNV: 89899 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGPD8 |
|
Disorders
/ Diseases
for RGPD8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RGPD8 for disorders About MalaCards
RGPD8 for disorders About GeneDecksing
OMIM gene information: 602752
OMIM disorders: --
Export disorders for RGPD8 gene to outside databases
|
Publications
for RGPD8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RGPD8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RGPD8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11- q12. (PubMed id 9480752)1, 2, 3 Nothwang H.G.... Hildebrandt F. (1998)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Complex genomic rearrangements lead to novel primate gene function. (PubMed id 15710750)1 Ciccarelli F.D.... Bork P. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PubMed id 11303027)2 Van Valkenburgh H.... Kahn R.A. (2001)
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External Searches for RGPD8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RGPD8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing RGPD8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RGPD8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RGPD8 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RGPD8 gene:
Search GeneIP for patents involving RGPD8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RGPD8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RGPD8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RGPD8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RGPD8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RGPD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RGPD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RGPD8 |
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| | | | Search Tocris compounds for RGPD8 |
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 | | | RGPD8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RGPD8 |
|  |  |  | | | | Search ThermoFisher Antibodies for RGPD8 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RGPD8 |
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