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Aliases for RGPD6 Gene

Aliases for RGPD6 Gene

  • RANBP2-Like And GRIP Domain Containing 6 2 3
  • RGP6 3 4 6
  • Ran-Binding Protein 2-Like 1/2 3 4
  • RanBP2-Like 1/2 3 4
  • RanBP2L2 3 4
  • RanBP2L1 3 4
  • RGPD7 3 4
  • RANBP2-Like And GRIP Domain-Containing Protein 5/6 3
  • RANBP2-Like And GRIP Domain-Containing Protein 7 3
  • Sperm Membrane Protein BS-63 4
  • RGPD5 RGPD6 4
  • RGP5 4
  • RGP7 4

External Ids for RGPD6 Gene

Summaries for RGPD6 Gene

GeneCards Summary for RGPD6 Gene

RGPD6 (RANBP2-Like And GRIP Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is PPIE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD6 Gene

Genomics for RGPD6 Gene

Genomic Location for RGPD6 Gene

Start:
110,513,802 bp from pter
End:
110,578,732 bp from pter
Size:
64,931 bases
Orientation:
Minus strand

Genomic View for RGPD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGPD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD6 Gene

Regulatory Elements for RGPD6 Gene

Proteins for RGPD6 Gene

  • Protein details for RGPD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99666-RGPD5_HUMAN
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 5/6
    Protein Accession:
    Q99666
    Secondary Accessions:
    • Q53QN2
    • Q53T03
    • Q59GM7
    • Q9H0B2

    Protein attributes for RGPD6 Gene

    Size:
    1765 amino acids
    Molecular mass:
    198924 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere

    Alternative splice isoforms for RGPD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGPD6 Gene

Proteomics data for RGPD6 Gene at MOPED

Post-translational modifications for RGPD6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys106, Lys1085, Lys1180, Lys1205, Lys1382, Lys1420, and Lys1448

Other Protein References for RGPD6 Gene

No data available for DME Specific Peptides for RGPD6 Gene

Domains for RGPD6 Gene

Gene Families for RGPD6 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for RGPD6 Gene

Suggested Antigen Peptide Sequences for RGPD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99666

UniProtKB/Swiss-Prot:

RGPD5_HUMAN
Domain:
  • Contains 1 GRIP domain.:
    • Q99666
  • Contains 2 RanBD1 domains.:
    • Q99666
Similarity:
  • Contains 3 TPR repeats.:
    • Q99666
genes like me logo Genes that share domains with RGPD6: view

Function for RGPD6 Gene

Gene Ontology (GO) - Molecular Function for RGPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGPD6: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RGPD6 Gene

Localization for RGPD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGPD6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGPD6 Gene COMPARTMENTS Subcellular localization image for RGPD6 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RGPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RGPD6: view

Pathways for RGPD6 Gene

SuperPathways for RGPD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RGPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0046907 intracellular transport --
genes like me logo Genes that share ontologies with RGPD6: view

No data available for Pathways by source for RGPD6 Gene

Transcripts for RGPD6 Gene

mRNA/cDNA for RGPD6 Gene

(10) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD6 Gene

RANBP2-like and GRIP domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD6 Gene

No ASD Table

Relevant External Links for RGPD6 Gene

GeneLoc Exon Structure for
RGPD6
ECgene alternative splicing isoforms for
RGPD6

Expression for RGPD6 Gene

mRNA expression in normal human tissues for RGPD6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGPD6 Gene

SOURCE GeneReport for Unigene cluster for RGPD6 Gene Hs.645445

mRNA Expression by UniProt/SwissProt for RGPD6 Gene

Q99666-RGPD5_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with RGPD6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RGPD6 Gene

Orthologs for RGPD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
ManyToMany
-- 36
  • 92 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia RANBP2 35
  • 85.03 (n)
  • 84.22 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 16 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ranbp2 35
  • 87.56 (n)
  • 88.11 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 44 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
RANBP2 35
  • 70.83 (n)
  • 68.66 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 35
  • 66.47 (n)
  • 62.47 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 35
  • 56.16 (n)
  • 54.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 9 (a)
ManyToMany
Y17G9B.4 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 5 (a)
OneToMany
Species with no ortholog for RGPD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD6 Gene

ENSEMBL:
Gene Tree for RGPD6 (if available)
TreeFam:
Gene Tree for RGPD6 (if available)

Paralogs for RGPD6 Gene

Paralogs for RGPD6 Gene

Selected SIMAP similar genes for RGPD6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGPD6: view

Variants for RGPD6 Gene

Sequence variations from dbSNP and Humsavar for RGPD6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2464078 -- 110,524,554(-) TTATA(G/T)TGTTC intron-variant
rs3860394 -- 110,569,752(+) TTTAT(A/G/T)TTTCA intron-variant
rs3860397 -- 110,569,644(+) GTTAC(A/G)GTTTG intron-variant
rs3930225 -- 110,552,241(-) GTCTC(A/G)GCGCA intron-variant
rs55673241 -- 110,525,032(+) AGACT(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD6 Gene

Variant ID Type Subtype PubMed ID
nsv874777 CNV Gain 21882294
nsv510884 CNV Complex 20534489
esv2751812 CNV Loss 17911159
dgv4263n71 CNV Gain 21882294
nsv508159 CNV Loss 20534489

Relevant External Links for RGPD6 Gene

HapMap Linkage Disequilibrium report
RGPD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD6 Gene

Disorders for RGPD6 Gene

No disorders were found for RGPD6 Gene.

No data available for UniProtKB/Swiss-Prot for RGPD6 Gene

Publications for RGPD6 Gene

  1. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli F.D. … Bork P. (Genome Res. 2005) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 3 4
  3. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11- q12. (PMID: 9480752) Nothwang H.G. … Hildebrandt F. (Genomics 1998) 2 3
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PMID: 18220336) Cantin G.T. … Yates J.R. III (J. Proteome Res. 2008) 3 4

Products for RGPD6 Gene

Sources for RGPD6 Gene

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