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Aliases for RGPD6 Gene

Aliases for RGPD6 Gene

  • RANBP2-Like And GRIP Domain Containing 6 2 3
  • Ran-Binding Protein 2-Like 1/2 3 4
  • RanBP2-Like 1/2 3 4
  • RanBP2L2 3 4
  • RanBP2L1 3 4
  • RGPD7 3 4
  • RGP6 3 4
  • RANBP2-Like And GRIP Domain-Containing Protein 7 3
  • Sperm Membrane Protein BS-63 4
  • RGPD5 RGPD6 4
  • RGP5 4
  • RGP7 4

External Ids for RGPD6 Gene

Previous GeneCards Identifiers for RGPD6 Gene

  • GC02U900804
  • GC02M110708
  • GC02M111271

Summaries for RGPD6 Gene

GeneCards Summary for RGPD6 Gene

RGPD6 (RANBP2-Like And GRIP Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is PPIE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD6 Gene

Genomics for RGPD6 Gene

Regulatory Elements for RGPD6 Gene

Genomic Location for RGPD6 Gene

110,513,802 bp from pter
110,610,888 bp from pter
97,087 bases
Minus strand

Genomic View for RGPD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGPD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD6 Gene

Proteins for RGPD6 Gene

  • Protein details for RGPD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 5/6
    Protein Accession:
    Secondary Accessions:
    • Q53QN2
    • Q53T03
    • Q59GM7
    • Q9H0B2

    Protein attributes for RGPD6 Gene

    1765 amino acids
    Molecular mass:
    198924 Da
    Quaternary structure:
    No Data Available
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere

    Alternative splice isoforms for RGPD6 Gene


neXtProt entry for RGPD6 Gene

Proteomics data for RGPD6 Gene at MOPED

Post-translational modifications for RGPD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGPD6 Gene

No data available for DME Specific Peptides for RGPD6 Gene

Domains & Families for RGPD6 Gene

Gene Families for RGPD6 Gene

Protein Domains for RGPD6 Gene

Suggested Antigen Peptide Sequences for RGPD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GRIP domain.
  • Contains 3 TPR repeats.
  • Contains 1 GRIP domain.
  • Contains 2 RanBD1 domains.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with RGPD6: view

Function for RGPD6 Gene

Gene Ontology (GO) - Molecular Function for RGPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGPD6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGPD6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGPD6 Gene

Localization for RGPD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGPD6 Gene

Subcellular locations from

Jensen Localization Image for RGPD6 Gene COMPARTMENTS Subcellular localization image for RGPD6 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for RGPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RGPD6: view

Pathways & Interactions for RGPD6 Gene

SuperPathways for RGPD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RGPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0046907 intracellular transport --
genes like me logo Genes that share ontologies with RGPD6: view

No data available for Pathways by source and SIGNOR curated interactions for RGPD6 Gene

Drugs & Compounds for RGPD6 Gene

No Compound Related Data Available

Transcripts for RGPD6 Gene

mRNA/cDNA for RGPD6 Gene

(10) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGPD6 Gene

RANBP2-like and GRIP domain containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGPD6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD6 Gene

No ASD Table

Relevant External Links for RGPD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD6 Gene

mRNA expression in normal human tissues for RGPD6 Gene

Protein differential expression in normal tissues from HIPED for RGPD6 Gene

This gene is overexpressed in Nasal epithelium (25.0), Testis (21.2), and Ovary (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGPD6 Gene

SOURCE GeneReport for Unigene cluster for RGPD6 Gene Hs.645445

mRNA Expression by UniProt/SwissProt for RGPD6 Gene

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with RGPD6: view

Protein tissue co-expression partners for RGPD6 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RGPD6 Gene

Orthologs for RGPD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RANBP2 35
  • 85.03 (n)
  • 84.22 (a)
(Mus musculus)
Mammalia Ranbp2 35
  • 87.56 (n)
  • 88.11 (a)
(Canis familiaris)
Mammalia -- 36
  • 16 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
-- 36
  • 83 (a)
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
-- 36
  • 92 (a)
-- 36
  • 82 (a)
-- 36
  • 96 (a)
(Gallus gallus)
Aves RANBP2 35
  • 70.83 (n)
  • 68.66 (a)
-- 36
  • 44 (a)
-- 36
  • 59 (a)
-- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 35
  • 66.47 (n)
  • 62.47 (a)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 35
  • 56.16 (n)
  • 54.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 9 (a)
Y17G9B.4 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 5 (a)
Species with no ortholog for RGPD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD6 Gene

Gene Tree for RGPD6 (if available)
Gene Tree for RGPD6 (if available)

Paralogs for RGPD6 Gene

Paralogs for RGPD6 Gene

(7) SIMAP similar genes for RGPD6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RGPD6: view

Variants for RGPD6 Gene

Sequence variations from dbSNP and Humsavar for RGPD6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2464078 -- 110,524,554(-) TTATA(G/T)TGTTC intron-variant
rs2699691 -- 110,569,572(-) TATGT(C/T)CTTAG intron-variant
rs3860394 -- 110,569,752(+) TTTAT(A/G/T)TTTCA intron-variant
rs3860397 -- 110,569,644(+) GTTAC(A/G)GTTTG intron-variant
rs3930225 -- 110,552,241(-) GTCTC(A/G)GCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD6 Gene

Variant ID Type Subtype PubMed ID
nsv874777 CNV Gain 21882294
nsv510884 CNV Complex 20534489
esv2751812 CNV Loss 17911159
dgv4263n71 CNV Gain 21882294
nsv508159 CNV Loss 20534489

Variation tolerance for RGPD6 Gene

Gene Damage Index Score: 0.01; 0.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGPD6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGPD6 Gene

Disorders for RGPD6 Gene

Relevant External Links for RGPD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RGPD6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD6 Gene

Publications for RGPD6 Gene

  1. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli F.D. … Bork P. (Genome Res. 2005) 2 67
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 67
  3. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11- q12. (PMID: 9480752) Nothwang H.G. … Hildebrandt F. (Genomics 1998) 2 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PMID: 23463506) Perez-Hernandez D. … YA!A+ez-MA^ M. (J. Biol. Chem. 2013) 67

Products for RGPD6 Gene

Sources for RGPD6 Gene

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