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Aliases for RGPD5 Gene

Aliases for RGPD5 Gene

  • RANBP2-Like And GRIP Domain Containing 5 2 3 5
  • Ran-Binding Protein 2-Like 1/2 3 4
  • Sperm Membrane Protein BS-63 3 4
  • RanBP2-Like 1/2 3 4
  • RanBP2L1 3 4
  • RGP5 3 4
  • RANBP2-Like And GRIP Domain-Containing Protein 5/6 3
  • RANBP2-Like And GRIP Domain-Containing Protein 5 3
  • Epididymis Luminal Protein 161 3
  • Ran-Binding Protein 2-Like 1 3
  • RanBP2-Like 1 3
  • RGPD5 RGPD6 4
  • RanBP2L2 4
  • HEL161 3
  • BS-63 3
  • RGPD7 4
  • BS63 3
  • RGP6 4
  • RGP7 4

External Ids for RGPD5 Gene

Previous GeneCards Identifiers for RGPD5 Gene

  • GC02P109908
  • GC02P110550

Summaries for RGPD5 Gene

Entrez Gene Summary for RGPD5 Gene

  • RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGPD5 Gene

RGPD5 (RANBP2-Like And GRIP Domain Containing 5) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is RGPD6.

Gene Wiki entry for RGPD5 Gene

Additional gene information for RGPD5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD5 Gene

Genomics for RGPD5 Gene

Regulatory Elements for RGPD5 Gene

Enhancers for RGPD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H109661 0.6 dbSUPER 5.8 -97.4 -97445 3.2 SOX5 CTCF MAZ NFIA TRIM22 RAD21 KAT8 SMC3 FOS HNF4A RGPD5 LIMS3 ENSG00000186148 SOWAHC ENSG00000230603 GC02M109643
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGPD5 on UCSC Golden Path with GeneCards custom track

Promoters for RGPD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121565 -7 801

Transcription factor binding sites by QIAGEN in the RGPD5 gene promoter:

Genomic Locations for RGPD5 Gene

Genomic Locations for RGPD5 Gene
97,089 bases
Plus strand

Genomic View for RGPD5 Gene

Genes around RGPD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGPD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGPD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD5 Gene

Proteins for RGPD5 Gene

  • Protein details for RGPD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 5/6
    Protein Accession:
    Secondary Accessions:
    • Q53QN2
    • Q53T03
    • Q59GM7
    • Q9H0B2

    Protein attributes for RGPD5 Gene

    1765 amino acids
    Molecular mass:
    198924 Da
    Quaternary structure:
    No Data Available
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

    Alternative splice isoforms for RGPD5 Gene


neXtProt entry for RGPD5 Gene

Post-translational modifications for RGPD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGPD5 Gene

Domains & Families for RGPD5 Gene

Gene Families for RGPD5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGPD5: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RGPD5 Gene

Function for RGPD5 Gene

genes like me logo Genes that share phenotypes with RGPD5: view

Animal Model Products

miRNA for RGPD5 Gene

miRTarBase miRNAs that target RGPD5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGPD5 Gene

Localization for RGPD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGPD5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGPD5 gene
Compartment Confidence
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RGPD5: view

Pathways & Interactions for RGPD5 Gene

SuperPathways for RGPD5 Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD5: view

Pathways by source for RGPD5 Gene

1 KEGG pathway for RGPD5 Gene

Gene Ontology (GO) - Biological Process for RGPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046907 intracellular transport IEA --
genes like me logo Genes that share ontologies with RGPD5: view

No data available for SIGNOR curated interactions for RGPD5 Gene

Drugs & Compounds for RGPD5 Gene

No Compound Related Data Available

Transcripts for RGPD5 Gene

Unigene Clusters for RGPD5 Gene

RANBP2-like and GRIP domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD5 Gene

No ASD Table

Relevant External Links for RGPD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGPD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGPD5 Gene

Protein differential expression in normal tissues from HIPED for RGPD5 Gene

This gene is overexpressed in Nasal epithelium (25.0), Testis (21.2), and Ovary (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RGPD5 Gene

Protein tissue co-expression partners for RGPD5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RGPD5 Gene:


SOURCE GeneReport for Unigene cluster for RGPD5 Gene:


mRNA Expression by UniProt/SwissProt for RGPD5 Gene:

Tissue specificity: Expressed in testis.

Evidence on tissue expression from TISSUES for RGPD5 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RGPD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGPD5 Gene

Orthologs for RGPD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
-- 34
  • 96 (a)
-- 34
  • 92 (a)
-- 34
  • 82 (a)
(Mus musculus)
Mammalia Ranbp2 33
  • 87.56 (n)
(Bos Taurus)
Mammalia RANBP2 33
  • 85.03 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
-- 34
  • 74 (a)
(Gallus gallus)
Aves RANBP2 33
  • 70.83 (n)
-- 34
  • 59 (a)
-- 34
  • 48 (a)
-- 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 33
  • 66.47 (n)
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 33
  • 56.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea Y17G9B.4 34
  • 13 (a)
T22F3.12 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 5 (a)
Species where no ortholog for RGPD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD5 Gene

Gene Tree for RGPD5 (if available)
Gene Tree for RGPD5 (if available)

Paralogs for RGPD5 Gene

(7) SIMAP similar genes for RGPD5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RGPD5: view

Variants for RGPD5 Gene

Sequence variations from dbSNP and Humsavar for RGPD5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000098584 -- 109,772,680(+) AGGGC(C/T)TTAAG intron-variant
rs1000510827 -- 109,780,216(+) TTTCC(A/G)AATTT intron-variant
rs1000736114 -- 109,763,571(+) AACAA(-/AGAG)AGAGA intron-variant
rs1001023292 -- 109,763,320(+) GTTCC(A/C)TTTTA intron-variant
rs1001104189 -- 109,779,073(+) TGTGG(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD5 Gene

Variant ID Type Subtype PubMed ID
esv2751812 CNV loss 17911159
esv3575292 CNV gain 25503493
esv3584010 CNV loss 25503493
esv3584017 CNV loss 25503493
nsv1003103 CNV gain+loss 25217958
nsv1077368 CNV duplication 25765185
nsv1124804 CNV duplication 24896259
nsv1141358 CNV duplication 24896259
nsv1146907 CNV duplication 26484159
nsv1149522 OTHER inversion 26484159
nsv1153351 CNV duplication 26484159
esv2720536 CNV deletion 23290073
dgv730e214 CNV gain 21293372
dgv4047n100 CNV loss 25217958
dgv4037n100 CNV gain 25217958
dgv1163e212 CNV loss 25503493
dgv1162e212 CNV gain 25503493
nsv979101 CNV duplication 23825009
nsv979088 CNV duplication 23825009
nsv963835 CNV duplication 23825009
nsv961864 CNV duplication 23825009
nsv961637 CNV duplication 23825009
nsv953789 CNV deletion 24416366
nsv510884 OTHER complex 20534489
nsv508159 CNV deletion 20534489

Relevant External Links for RGPD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RGPD5 Gene

Disorders for RGPD5 Gene

Relevant External Links for RGPD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RGPD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD5 Gene

Publications for RGPD5 Gene

  1. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli FD … Bork P (Genome research 2005) 2 3 4 60
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 2 3 4 60
  3. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. (PMID: 10101573) Wang LF … Koide SS (Archives of andrology 1999) 3 4 22 60
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RGPD5 Gene

Sources for RGPD5 Gene

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