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Aliases for RGPD5 Gene

Aliases for RGPD5 Gene

  • RANBP2-Like And GRIP Domain Containing 5 2 3
  • Ran-Binding Protein 2-Like 1/2 3 4
  • Sperm Membrane Protein BS-63 3 4
  • RanBP2-Like 1/2 3 4
  • RanBP2L1 3 4
  • RGP5 3 4
  • RANBP2-Like And GRIP Domain-Containing Protein 5 3
  • Epididymis Luminal Protein 161 3
  • Ran-Binding Protein 2-Like 1 3
  • RanBP2-Like 1 3
  • RGPD5 RGPD6 4
  • RanBP2L2 4
  • HEL161 3
  • BS-63 3
  • RGPD7 4
  • BS63 3
  • RGP6 4
  • RGP7 4

External Ids for RGPD5 Gene

Previous GeneCards Identifiers for RGPD5 Gene

  • GC02P109908
  • GC02P110550

Summaries for RGPD5 Gene

Entrez Gene Summary for RGPD5 Gene

  • RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGPD5 Gene

RGPD5 (RANBP2-Like And GRIP Domain Containing 5) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is PPIE.

Gene Wiki entry for RGPD5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGPD5 Gene

Genomics for RGPD5 Gene

Regulatory Elements for RGPD5 Gene

Transcription factor binding sites by QIAGEN in the RGPD5 gene promoter:

Genomic Location for RGPD5 Gene

Chromosome:
2
Start:
109,760,607 bp from pter
End:
109,857,695 bp from pter
Size:
97,089 bases
Orientation:
Plus strand

Genomic View for RGPD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGPD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGPD5 Gene

Proteins for RGPD5 Gene

  • Protein details for RGPD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99666-RGPD5_HUMAN
    Recommended name:
    RANBP2-like and GRIP domain-containing protein 5/6
    Protein Accession:
    Q99666
    Secondary Accessions:
    • Q53QN2
    • Q53T03
    • Q59GM7
    • Q9H0B2

    Protein attributes for RGPD5 Gene

    Size:
    1765 amino acids
    Molecular mass:
    198924 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere

    Alternative splice isoforms for RGPD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGPD5 Gene

Proteomics data for RGPD5 Gene at MOPED

Post-translational modifications for RGPD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGPD5 Gene

No data available for DME Specific Peptides for RGPD5 Gene

Domains & Families for RGPD5 Gene

Gene Families for RGPD5 Gene

Protein Domains for RGPD5 Gene

Graphical View of Domain Structure for InterPro Entry

Q99666

UniProtKB/Swiss-Prot:

RGPD5_HUMAN :
  • Contains 1 GRIP domain.
  • Contains 3 TPR repeats.
Domain:
  • Contains 1 GRIP domain.
  • Contains 2 RanBD1 domains.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with RGPD5: view

No data available for Suggested Antigen Peptide Sequences for RGPD5 Gene

Function for RGPD5 Gene

Gene Ontology (GO) - Molecular Function for RGPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RGPD5: view

Phenotypes for RGPD5 Gene

genes like me logo Genes that share phenotypes with RGPD5: view

Animal Model Products

CRISPR Products

miRNA for RGPD5 Gene

miRTarBase miRNAs that target RGPD5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGPD5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RGPD5 Gene

Localization for RGPD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGPD5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGPD5 Gene COMPARTMENTS Subcellular localization image for RGPD5 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for RGPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RGPD5: view

Pathways & Interactions for RGPD5 Gene

SuperPathways for RGPD5 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with RGPD5: view

Pathways by source for RGPD5 Gene

1 KEGG pathway for RGPD5 Gene

Gene Ontology (GO) - Biological Process for RGPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0046907 intracellular transport --
genes like me logo Genes that share ontologies with RGPD5: view

No data available for SIGNOR curated interactions for RGPD5 Gene

Drugs & Compounds for RGPD5 Gene

No Compound Related Data Available

Transcripts for RGPD5 Gene

Unigene Clusters for RGPD5 Gene

RANBP2-like and GRIP domain containing 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RGPD5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGPD5 Gene

No ASD Table

Relevant External Links for RGPD5 Gene

GeneLoc Exon Structure for
RGPD5
ECgene alternative splicing isoforms for
RGPD5

Expression for RGPD5 Gene

mRNA expression in normal human tissues for RGPD5 Gene

Protein differential expression in normal tissues from HIPED for RGPD5 Gene

This gene is overexpressed in Nasal epithelium (25.0), Testis (21.2), and Ovary (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RGPD5 Gene



SOURCE GeneReport for Unigene cluster for RGPD5 Gene Hs.469630

mRNA Expression by UniProt/SwissProt for RGPD5 Gene

Q99666-RGPD5_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with RGPD5: view

Protein tissue co-expression partners for RGPD5 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RGPD5 Gene

Orthologs for RGPD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGPD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RANBP2 35
  • 85.03 (n)
  • 84.22 (a)
mouse
(Mus musculus)
Mammalia Ranbp2 35
  • 87.56 (n)
  • 88.11 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
ManyToMany
-- 36
  • 92 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RANBP2 35
  • 70.83 (n)
  • 68.66 (a)
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp2 35
  • 66.47 (n)
  • 62.47 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-55a19.2 35
  • 56.16 (n)
  • 54.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 9 (a)
ManyToMany
Y17G9B.4 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 5 (a)
OneToMany
Species with no ortholog for RGPD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGPD5 Gene

ENSEMBL:
Gene Tree for RGPD5 (if available)
TreeFam:
Gene Tree for RGPD5 (if available)

Paralogs for RGPD5 Gene

Paralogs for RGPD5 Gene

(7) SIMAP similar genes for RGPD5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RGPD5: view

Variants for RGPD5 Gene

Sequence variations from dbSNP and Humsavar for RGPD5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9212 -- 109,857,316(+) AAATA(C/T)CTCAT utr-variant-3-prime
rs15849 -- 109,855,876(+) AAAAT(C/G)CTTCC missense, reference
rs1061211 -- 109,855,960(+) TTAAC(C/T)AAATA utr-variant-3-prime
rs2433855 -- 109,792,514(+) AGATG(C/T)AGGAG upstream-variant-2KB, intron-variant
rs2438818 -- 109,797,334(+) GGTCA(C/G)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGPD5 Gene

Variant ID Type Subtype PubMed ID
nsv874777 CNV Gain 21882294
nsv510884 CNV Complex 20534489
esv2751812 CNV Loss 17911159
dgv4263n71 CNV Gain 21882294
nsv508159 CNV Loss 20534489
nsv874863 CNV Loss 21882294
nsv874871 CNV Gain 21882294
esv2720536 CNV Deletion 23290073

Relevant External Links for RGPD5 Gene

HapMap Linkage Disequilibrium report
RGPD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RGPD5 Gene

Disorders for RGPD5 Gene

Relevant External Links for RGPD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGPD5
genes like me logo Genes that share disorders with RGPD5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGPD5 Gene

Publications for RGPD5 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 2 67
  2. Complex genomic rearrangements lead to novel primate gene function. (PMID: 15710750) Ciccarelli F.D. … Bork P. (Genome Res. 2005) 2 67
  3. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. (PMID: 10101573) Wang L.F. … Koide S.S. (Arch. Androl. 1999) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for RGPD5 Gene

Sources for RGPD5 Gene

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